P Taroni

Summary

Affiliation: Politecnico di Milano
Country: Italy

Publications

  1. ncbi request reprint Bulk optical properties and tissue components in the female breast from multiwavelength time-resolved optical mammography
    Lorenzo Spinelli
    INFM, Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133, Milan, Italy
    J Biomed Opt 9:1137-42. 2004
  2. ncbi request reprint Time-resolved optical mammography between 637 and 985 nm: clinical study on the detection and identification of breast lesions
    Paola Taroni
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Phys Med Biol 50:2469-88. 2005
  3. doi request reprint Diffuse optical imaging and spectroscopy of the breast: a brief outline of history and perspectives
    Paola Taroni
    Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milan, Italy
    Photochem Photobiol Sci 11:241-50. 2012
  4. ncbi request reprint Time-resolved microspectrofluorimetry and fluorescence lifetime imaging of hypericin in human retinal pigment epithelial cells
    Paola Taroni
    INFM Department of Physics and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
    Photochem Photobiol 81:524-8. 2005
  5. ncbi request reprint Clinical trial of time-resolved scanning optical mammography at 4 wavelengths between 683 and 975 nm
    Paola Taroni
    Politecnico di Milano, INFM Dipartimento di Fisica, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    J Biomed Opt 9:464-73. 2004
  6. ncbi request reprint Multi-wavelength time domain optical mammography
    P Taroni
    CNR INFM and CNR IFN, Politecnico di Milano Dipartimento di Fisica, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Technol Cancer Res Treat 4:527-38. 2005
  7. ncbi request reprint Absorption of collagen: effects on the estimate of breast composition and related diagnostic implications
    Paola Taroni
    Politecnico di Milano, Dipartimento di Fisica, ULTRAS CNR INFM and IFN CNR, Piazza Leonardo da Vinci 32, I 20133 Milano, Italy
    J Biomed Opt 12:014021. 2007
  8. doi request reprint Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantification
    Paola Taroni
    Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
    Opt Express 17:15932-46. 2009
  9. doi request reprint Diffuse optical spectroscopy of breast tissue extended to 1100 nm
    Paola Taroni
    Politecnico di Milano, Dipartimento di Fisica and Consiglio Nazionale delle Ricerche, Istituto di Fotonica e Nanotecnologie, Piazza Leonardo da Vinci 32, Milan, 20133, Italy
    J Biomed Opt 14:054030. 2009
  10. ncbi request reprint Time-resolved diffuse optical spectroscopy: a differential absorption approach
    Paola Taroni
    Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
    Appl Spectrosc 64:1220-6. 2010

Detail Information

Publications36

  1. ncbi request reprint Bulk optical properties and tissue components in the female breast from multiwavelength time-resolved optical mammography
    Lorenzo Spinelli
    INFM, Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133, Milan, Italy
    J Biomed Opt 9:1137-42. 2004
    ..These results suggest that optical measurements on breasts can be exploited to obtain relevant information on breast tissue composition...
  2. ncbi request reprint Time-resolved optical mammography between 637 and 985 nm: clinical study on the detection and identification of breast lesions
    Paola Taroni
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Phys Med Biol 50:2469-88. 2005
    ..The capacity to assess the density of breast based on the average scattering properties was also tested...
  3. doi request reprint Diffuse optical imaging and spectroscopy of the breast: a brief outline of history and perspectives
    Paola Taroni
    Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milan, Italy
    Photochem Photobiol Sci 11:241-50. 2012
    ..This paper outlines the historical evolution of optical imaging and spectroscopy of the breast, highlighting potentialities and limitations, and presents an overview of the main applications and perspectives of the field...
  4. ncbi request reprint Time-resolved microspectrofluorimetry and fluorescence lifetime imaging of hypericin in human retinal pigment epithelial cells
    Paola Taroni
    INFM Department of Physics and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
    Photochem Photobiol 81:524-8. 2005
    ..The latter change is observed also when high concentrations are reached locally, due to more efficient localization within the cell...
  5. ncbi request reprint Clinical trial of time-resolved scanning optical mammography at 4 wavelengths between 683 and 975 nm
    Paola Taroni
    Politecnico di Milano, INFM Dipartimento di Fisica, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    J Biomed Opt 9:464-73. 2004
    ..The effectiveness of the technique in localizing and discriminating different lesion types is analyzed as a function of various parameters (lesion size, compressed breast thickness, and breast parenchymal pattern). ...
  6. ncbi request reprint Multi-wavelength time domain optical mammography
    P Taroni
    CNR INFM and CNR IFN, Politecnico di Milano Dipartimento di Fisica, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Technol Cancer Res Treat 4:527-38. 2005
    ..Moreover, the new wavelengths contribute to the qualitatively identify tissue composition from intensity images, and could assist lesion detection...
  7. ncbi request reprint Absorption of collagen: effects on the estimate of breast composition and related diagnostic implications
    Paola Taroni
    Politecnico di Milano, Dipartimento di Fisica, ULTRAS CNR INFM and IFN CNR, Piazza Leonardo da Vinci 32, I 20133 Milano, Italy
    J Biomed Opt 12:014021. 2007
    ..Adding collagen to the fitting procedure affects remarkably the estimated values of blood content and oxygenation. The quantification of collagen has potential implications for the assessment of breast density and cancer risk...
  8. doi request reprint Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantification
    Paola Taroni
    Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
    Opt Express 17:15932-46. 2009
    ..Then images were collected at 7 wavelengths (635-1060 nm) from 10 healthy volunteers. Average collagen content correlated with breast density whenever x-ray mammograms were available (6 subjects)...
  9. doi request reprint Diffuse optical spectroscopy of breast tissue extended to 1100 nm
    Paola Taroni
    Politecnico di Milano, Dipartimento di Fisica and Consiglio Nazionale delle Ricerche, Istituto di Fotonica e Nanotecnologie, Piazza Leonardo da Vinci 32, Milan, 20133, Italy
    J Biomed Opt 14:054030. 2009
    ....
  10. ncbi request reprint Time-resolved diffuse optical spectroscopy: a differential absorption approach
    Paola Taroni
    Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
    Appl Spectrosc 64:1220-6. 2010
    ....
  11. doi request reprint Noninvasive assessment of breast cancer risk using time-resolved diffuse optical spectroscopy
    Paola Taroni
    Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milano, Italy
    J Biomed Opt 15:060501. 2010
    ..A synthetic optical index proves to be quite effective in separating different breast density categories. Finally, the estimate of collagen content as a more direct means for the assessment of breast cancer risk is discussed...
  12. ncbi request reprint Do shorter wavelengths improve contrast in optical mammography?
    P Taroni
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Phys Med Biol 49:1203-15. 2004
    ..5 cm diameter). For cysts either a progressive increase or decrease in contrast with wavelength was observed in scattering images...
  13. ncbi request reprint Fluorescence imaging during photodynamic therapy of experimental tumors in mice sensitized with disulfonated aluminum phthalocyanine
    R Cubeddu
    INFM Dipartimento di Fisica and CEQSE CNR, Politecnico di Milano, Italy
    Photochem Photobiol 72:690-5. 2000
    ..This ratio increases monotonically during the PDT, showing a different behavior with the two excitation wavelengths. This indicates that the AlS2Pc absorption spectrum shifts toward shorter wavelengths as a result of the irradiation...
  14. ncbi request reprint Study of porphyrin fluorescence in tissue samples of tumour-bearing mice
    R Cubeddu
    CEQSE CNR, Dipartimento di Fisica, Politecnico di Milano, Italy
    J Photochem Photobiol B 29:171-8. 1995
    ..Nevertheless, the images show that porphyrins localize with different concentrations in all the examined tissues except the brain. Moreover, an appreciable long-living endogenous emission was observed in the bone...
  15. ncbi request reprint Absorption spectrum of hematoporphyrin derivative in vivo in a murine tumor model
    R Cubeddu
    C E Q S E C N R, Politecnico di Milano, Italy
    Photochem Photobiol 60:582-5. 1994
    ..Maximum absorption was measured at 620-625 nm. Similar spectral behavior was obtained for HpD in solution in the presence of low-density lipoproteins...
  16. ncbi request reprint Fluorescence lifetime imaging of experimental tumors in hematoporphyrin derivative-sensitized mice
    R Cubeddu
    Dipartimento di Fisica, Politecnico di Milano, Italy
    Photochem Photobiol 66:229-36. 1997
    ..The outcomes obtained with two techniques are in good agreement...
  17. ncbi request reprint Time-gated fluorescence imaging for the diagnosis of tumors in a murine model
    R Cubeddu
    C E Q S E C N R, Politecnico di Milano, Piazza L da Vinci, Milan, Italy
    Photochem Photobiol 57:480-5. 1993
    ..In this optimum condition, the tumor region could be identified even after the injection of 5 mg/kg HpD. A better fluorescence contrast was always obtained in 15 ns-delayed images with respect to synchronous ones...
  18. ncbi request reprint Effects of the menstrual cycle on the red and near-infrared optical properties of the human breast
    R Cubeddu
    INFM Dipartimento di Fisica, Politecnico di Milano, Italy
    Photochem Photobiol 72:383-91. 2000
    ..Significant changes in the estimated variables were observed with measurement geometry, reflecting the heterogeneous nature of the breast, and with time, in agreement with expected physiological changes over the menstrual cycle...
  19. ncbi request reprint Effects of photodynamic therapy on the absorption properties of disulphonated aluminum phthalocyanine in tumor-bearing mice
    R Cubeddu
    INFM Dipartimento di Fisica and CEQSE CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milan, Italy
    J Photochem Photobiol B 60:73-8. 2001
    ..The irradiation causes a blue-shift of the measured line shape, more or less marked depending on the experimental conditions. A reduction in absorption is also often observed upon illumination with therapeutic light doses...
  20. ncbi request reprint In vivo optical characterization of human tissues from 610 to 1010 nm by time-resolved reflectance spectroscopy
    A Torricelli
    INFM-Dipartimento di Fisica and CEQSE-CNR, Politecnico di Milano, Milan, Italy
    Phys Med Biol 46:2227-37. 2001
    ..The interpretation of transport scattering spectra with Mie theory provided information on tissue structure...
  21. ncbi request reprint Fully automated time domain spectrometer for the absorption and scattering characterization of diffusive media
    Antonio Pifferi
    ULTRAS CNR INFM and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Rev Sci Instrum 78:053103. 2007
    ..Finally, an example of application of the instrument to the spectroscopy of powders is presented...
  22. ncbi request reprint Mapping of calf muscle oxygenation and haemoglobin content during dynamic plantar flexion exercise by multi-channel time-resolved near-infrared spectroscopy
    Alessandro Torricelli
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, 1 20133 Milan, Italy
    Phys Med Biol 49:685-99. 2004
    ..02). These results strengthen the role of time-resolved near-infrared spectroscopy as a powerful tool for investigating the spatial and temporal features of muscle SmO2 and tHb...
  23. ncbi request reprint Characterization of female breast lesions from multi-wavelength time-resolved optical mammography
    Lorenzo Spinelli
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Phys Med Biol 50:2489-502. 2005
    ..For fibroadenomas, the low number of cases does not allow any definite conclusions...
  24. ncbi request reprint Spectroscopic time-resolved diffuse reflectance and transmittance measurements of the female breast at different interfiber distances
    Antonio Pifferi
    Politecnico di Milano, ULTRAS INFM, INF CNR, Dipartimento di Fisica, P L da Vinci 32, I 20133, Milano, Italy
    J Biomed Opt 9:1143-51. 2004
    ..The intrasubject variations are larger for the scattering data than the absorption data; this is consistent with different spatial localization of the measurements of these parameters, which is explained by the photon migration theory...
  25. ncbi request reprint Performance assessment of photon migration instruments: the MEDPHOT protocol
    Antonio Pifferi
    Laboratorio Nazionale per l Ottica Ultra rapida e Ultra intensa, Dipartimento di Fisica e Istituto di Fotonicae Nanotecnologie, Consiglio Nazionale delle Ricerche, Politecnico di Milano, I 20133 Milan, Italy
    Appl Opt 44:2104-14. 2005
    ..This protocol was applied to a total of 8 instruments with a set of 32 phantoms, covering a wide range of optical properties...
  26. ncbi request reprint Optical biopsy of bone tissue: a step toward the diagnosis of bone pathologies
    Antonio Pifferi
    ULTRAS INFM and IFN CNR, Dipartimento di Fisica Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    J Biomed Opt 9:474-80. 2004
    ....
  27. ncbi request reprint In vivo time-resolved reflectance spectroscopy of the human forehead
    Daniela Comelli
    Centre of Ultrafast and Ultraintense Optical Science, Consiglio Nazionale delle Ricerche, Istituto Nazionale de Fisica della Materia, Politecnico di Milano, Milano, Italy
    Appl Opt 46:1717-25. 2007
    ..e., scalp and skull) than to deeper layer ones (white and gray matter). In particular, for the shorter interfiber distances, the recovered values can be assumed as a good estimate of the optical properties of the first layer...
  28. doi request reprint Note: Comparison between a prism-based and an acousto-optic tunable filter-based spectrometer for diffusive media
    A Farina
    Consiglio Nazionale delle Ricerche, Istituto di Fotonica e Nanotecnologie, Piazza L da Vinci 32, I 20133 Milano, Italy
    Rev Sci Instrum 84:016109. 2013
    ..Simulations and experiments on diffusive phantoms confirmed that, besides narrower FWHM in the AOTF bandpass, the prism solution is superior with respect to the distortions produced on the recovered spectra...
  29. doi request reprint Time-resolved optical spectroscopy of wood
    C D'andrea
    CNR INFM and CNR IFN, Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy
    Appl Spectrosc 62:569-74. 2008
    ..In all the cases, alterations of absorption and scattering spectra were observed, revealing changes of chemical and structural composition...
  30. ncbi request reprint Four-wavelength time-resolved optical mammography in the 680-980-nm range
    Antonio Pifferi
    Istituto Nazionale per la Fisica della Materia, Dipartimento di Fisica e Istituto di Fotonica e Nanotecnologie, Consiglio Nazionale delle Ricerche, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Opt Lett 28:1138-40. 2003
    ..The system is currently used in a European clinical trial...
  31. ncbi request reprint In vivo absorption and scattering spectroscopy of biological tissues
    Paola Taroni
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Photochem Photobiol Sci 2:124-9. 2003
    ..Finally, an example of the applicability of the methodology to other biological media such as fruits and vegetables is shown...
  32. ncbi request reprint Experimental test of a perturbation model for time-resolved imaging in diffusive media
    Lorenzo Spinelli
    Istituto Nazionale per la Fisica della Materia, Dipartimento di Fisica and Centro di Elettronica Quantistica e Strumentazione Elettronica, Consiglo Nazionale delle Ricerche, Politecnico di Milano, Piazza Leonardo da Vinci 32, 1 20133 Milan, Italy
    Appl Opt 42:3145-53. 2003
    ....
  33. ncbi request reprint Phantom validation and in vivo application of an inversion procedure for retrieving the optical properties of diffusive layered media from time-resolved reflectance measurements
    Fabrizio Martelli
    Dipartimento di Fisica dell Università degli Studi di Firenze and Istituto Nazionale per la Fisica della Materia, Via G Sansone 1, 50019 Sesto Fiorentino, Florence, Italy
    Opt Lett 29:2037-9. 2004
    ..The first layer thickness could be retrieved with an error less than 50%. An example of retrieval of the optical properties of muscle from in vivo measurements during an arterial occlusion is shown...
  34. ncbi request reprint Light propagation in dry and wet softwood
    Alwin Kienle
    Institut fur Lasertechnologien in der Medizin und Messtechnik, Helmholtzstr 12, D 89081 Ulm, Germany
    Opt Express 16:9895-906. 2008
    ..Good qualitative agreement was obtained between the experimentally and theoretically derived optical properties...
  35. ncbi request reprint Determination of the optical properties of anisotropic biological media using an isotropic diffusion model
    Alwin Kienle
    Institut fur Lasertechnologien in der Medizin und Messtechnik, Helmholtzstrasse 12, D 89081 Ulm, Germany
    J Biomed Opt 12:014026. 2007
    ..Contrarily, the derived reduced scattering coefficient depends strongly on the measurement direction in both domains. Measurements of the steady-state and time-resolved reflectance from bovine tendon confirm the theoretical findings...
  36. ncbi request reprint Characterization of normal breast tissue heterogeneity using time-resolved near-infrared spectroscopy
    Tomas Svensson
    Department of Physics, Lund Institute of Technology, Box 118, SE 221 00 Lund, Sweden
    Phys Med Biol 50:2559-71. 2005
    ..Extracted physiological properties confirm differences between pre- and post-menopausal breast tissue. Results do not indicate systematic differences between left and right breasts...