Lorenzo Spinelli

Summary

Affiliation: Politecnico di Milano
Country: Italy

Publications

  1. ncbi request reprint Experimental test of a perturbation model for time-resolved imaging in diffusive media
    Lorenzo Spinelli
    Istituto Nazionale per la Fisica della Materia, Dipartimento di Fisica and Centro di Elettronica Quantistica e Strumentazione Elettronica, Consiglo Nazionale delle Ricerche, Politecnico di Milano, Piazza Leonardo da Vinci 32, 1 20133 Milan, Italy
    Appl Opt 42:3145-53. 2003
  2. ncbi request reprint Bulk optical properties and tissue components in the female breast from multiwavelength time-resolved optical mammography
    Lorenzo Spinelli
    INFM, Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133, Milan, Italy
    J Biomed Opt 9:1137-42. 2004
  3. ncbi request reprint Characterization of female breast lesions from multi-wavelength time-resolved optical mammography
    Lorenzo Spinelli
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Phys Med Biol 50:2489-502. 2005
  4. ncbi request reprint Time-resolved optical mammography between 637 and 985 nm: clinical study on the detection and identification of breast lesions
    Paola Taroni
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Phys Med Biol 50:2469-88. 2005
  5. ncbi request reprint Cerebral cortex activation mapping upon electrical muscle stimulation by 32-channel time-domain functional near-infrared spectroscopy
    Rebecca Re
    Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci, 32, Milan, I 20133, Italy
    Adv Exp Med Biol 789:441-7. 2013
  6. doi request reprint Deep and surface hemodynamic signal from functional time resolved transcranial near infrared spectroscopy compared to skin flowmotion
    Federico Aletti
    Dipartimento di Bioingegneria IIT Unit, Politecnico di Milano, Milan, Italy
    Comput Biol Med 42:282-9. 2012
  7. doi request reprint Load-dependent brain activation assessed by time-domain functional near-infrared spectroscopy during a working memory task with graded levels of difficulty
    Erika Molteni
    Dipartimento di Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    J Biomed Opt 17:056005. 2012
  8. doi request reprint Fast-gated single-photon counting technique widens dynamic range and speeds up acquisition time in time-resolved measurements
    Alberto Tosi
    Politecnico di Milano, Dipartimento di Elettronica e Informazione, Piazza Leonardo da Vinci 32, I 20133 Milano, Italy
    Opt Express 19:10735-46. 2011
  9. ncbi request reprint Clinical trial of time-resolved scanning optical mammography at 4 wavelengths between 683 and 975 nm
    Paola Taroni
    Politecnico di Milano, INFM Dipartimento di Fisica, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    J Biomed Opt 9:464-73. 2004
  10. ncbi request reprint Feasibility of white-light time-resolved optical mammography
    Andrea Bassi
    ULTRAS CNR INFM and CNR IFN, Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milano, Italy
    J Biomed Opt 11:054035. 2006

Detail Information

Publications25

  1. ncbi request reprint Experimental test of a perturbation model for time-resolved imaging in diffusive media
    Lorenzo Spinelli
    Istituto Nazionale per la Fisica della Materia, Dipartimento di Fisica and Centro di Elettronica Quantistica e Strumentazione Elettronica, Consiglo Nazionale delle Ricerche, Politecnico di Milano, Piazza Leonardo da Vinci 32, 1 20133 Milan, Italy
    Appl Opt 42:3145-53. 2003
    ....
  2. ncbi request reprint Bulk optical properties and tissue components in the female breast from multiwavelength time-resolved optical mammography
    Lorenzo Spinelli
    INFM, Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133, Milan, Italy
    J Biomed Opt 9:1137-42. 2004
    ..These results suggest that optical measurements on breasts can be exploited to obtain relevant information on breast tissue composition...
  3. ncbi request reprint Characterization of female breast lesions from multi-wavelength time-resolved optical mammography
    Lorenzo Spinelli
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Phys Med Biol 50:2489-502. 2005
    ..For fibroadenomas, the low number of cases does not allow any definite conclusions...
  4. ncbi request reprint Time-resolved optical mammography between 637 and 985 nm: clinical study on the detection and identification of breast lesions
    Paola Taroni
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Phys Med Biol 50:2469-88. 2005
    ..The capacity to assess the density of breast based on the average scattering properties was also tested...
  5. ncbi request reprint Cerebral cortex activation mapping upon electrical muscle stimulation by 32-channel time-domain functional near-infrared spectroscopy
    Rebecca Re
    Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci, 32, Milan, I 20133, Italy
    Adv Exp Med Biol 789:441-7. 2013
    ..This could be due in part to a nociceptive response to the higher EMS current intensities and result also from increased sensorimotor integration in these cortical regions. ..
  6. doi request reprint Deep and surface hemodynamic signal from functional time resolved transcranial near infrared spectroscopy compared to skin flowmotion
    Federico Aletti
    Dipartimento di Bioingegneria IIT Unit, Politecnico di Milano, Milan, Italy
    Comput Biol Med 42:282-9. 2012
    ..The deep cortical NIRS signal did not appear to be affected by surface vasomotor activity, and autoregulation dynamics were dominant with respect to autonomic control of circulation...
  7. doi request reprint Load-dependent brain activation assessed by time-domain functional near-infrared spectroscopy during a working memory task with graded levels of difficulty
    Erika Molteni
    Dipartimento di Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    J Biomed Opt 17:056005. 2012
    ..The present work successfully explored the capability of fNIRS to detect the two neurophysiological categories under investigation and distinguish their activation patterns...
  8. doi request reprint Fast-gated single-photon counting technique widens dynamic range and speeds up acquisition time in time-resolved measurements
    Alberto Tosi
    Politecnico di Milano, Dipartimento di Elettronica e Informazione, Piazza Leonardo da Vinci 32, I 20133 Milano, Italy
    Opt Express 19:10735-46. 2011
    ..In experimental measurements, we obtained a dynamic range approaching 8 decades in few minutes of acquisition...
  9. ncbi request reprint Clinical trial of time-resolved scanning optical mammography at 4 wavelengths between 683 and 975 nm
    Paola Taroni
    Politecnico di Milano, INFM Dipartimento di Fisica, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    J Biomed Opt 9:464-73. 2004
    ..The effectiveness of the technique in localizing and discriminating different lesion types is analyzed as a function of various parameters (lesion size, compressed breast thickness, and breast parenchymal pattern). ...
  10. ncbi request reprint Feasibility of white-light time-resolved optical mammography
    Andrea Bassi
    ULTRAS CNR INFM and CNR IFN, Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milano, Italy
    J Biomed Opt 11:054035. 2006
    ..Furthermore, measurements on a tissue-like sample demonstrate detection and characterization of inclusions...
  11. pmc Effects of tissue heterogeneity on the optical estimate of breast density
    Paola Taroni
    Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy
    Biomed Opt Express 3:2411-8. 2012
    ..A central position is optimal for the measurement, but its exact location is not critical...
  12. ncbi request reprint Effect of prolonged stimulation on cerebral hemodynamic: a time-resolved fNIRS study
    Michele Butti
    Dipartimento di Bioingegneria, IIT Unit, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Med Phys 36:4103-14. 2009
    ..In this article, the authors address the topic of characterizing the dynamics of cerebral metabolism in the prefrontal cortex during a task of prolonged attention...
  13. ncbi request reprint Mapping of calf muscle oxygenation and haemoglobin content during dynamic plantar flexion exercise by multi-channel time-resolved near-infrared spectroscopy
    Alessandro Torricelli
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, 1 20133 Milan, Italy
    Phys Med Biol 49:685-99. 2004
    ..02). These results strengthen the role of time-resolved near-infrared spectroscopy as a powerful tool for investigating the spatial and temporal features of muscle SmO2 and tHb...
  14. doi request reprint Monitoring muscle metabolic indexes by time-domain near-infrared spectroscopy during knee flex-extension induced by functional electrical stimulation
    Simona Ferrante
    Politecnico di Milano, Dipartimento di Bioingegneria, Neuro Engineering and Medical Robotics Laboratory, Piazza Leonardo da Vinci 32, Milano, 20133, Italy
    J Biomed Opt 14:044011. 2009
    ..It is crucial to enlarge the sample size of the two subgroups before making these preliminary results a general finding...
  15. doi request reprint Noninvasive assessment of breast cancer risk using time-resolved diffuse optical spectroscopy
    Paola Taroni
    Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milano, Italy
    J Biomed Opt 15:060501. 2010
    ..A synthetic optical index proves to be quite effective in separating different breast density categories. Finally, the estimate of collagen content as a more direct means for the assessment of breast cancer risk is discussed...
  16. doi request reprint Time domain functional NIRS imaging for human brain mapping
    Alessandro Torricelli
    Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, I 20133, Milan, Italy Electronic address
    Neuroimage 85:28-50. 2014
    ..Finally we give an account on the technological developments that would pave the way for a broader use of TD fNIRS in the neuroimaging community. ..
  17. ncbi request reprint Time-resolved diffuse reflectance using small source-detector separation and fast single-photon gating
    Antonio Pifferi
    IIT, ULTRAS INFM CNR and IFN CNR, Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Phys Rev Lett 100:138101. 2008
    ..Finally, the proposed approach proved valuable to detect in vivo a task-related brain activation...
  18. doi request reprint A compact time-resolved system for near infrared spectroscopy based on wavelength space multiplexing
    Rebecca Re
    Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Rev Sci Instrum 81:113101. 2010
    ..Finally, it was successfully tested in preliminary in vivo measurements on muscle during standard cuff occlusion and on the brain during a motor cortex response due to hand movements...
  19. doi request reprint Time-resolved scanning system for double reflectance and transmittance fluorescence imaging of diffusive media
    Marco Brambilla
    IIT, ULTRAS INFM CNR and IFN CNR, Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Rev Sci Instrum 79:013103. 2008
    ..We finally discuss some of the criticalities of the proposed system and the developments we are currently carrying on in order to adapt it for in vivo measurements...
  20. ncbi request reprint Time-resolved diffuse optical spectroscopy: a differential absorption approach
    Paola Taroni
    Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
    Appl Spectrosc 64:1220-6. 2010
    ....
  21. doi request reprint Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantification
    Paola Taroni
    Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
    Opt Express 17:15932-46. 2009
    ..Then images were collected at 7 wavelengths (635-1060 nm) from 10 healthy volunteers. Average collagen content correlated with breast density whenever x-ray mammograms were available (6 subjects)...
  22. ncbi request reprint Absorption and scattering perturbations in homogeneous and layered diffusive media probed by time-resolved reflectance at null source-detector separation
    Lorenzo Spinelli
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza L da Vinci 32, I 20133 Milan, Italy
    Phys Rev E Stat Nonlin Soft Matter Phys 74:021919. 2006
    ..Exhaustive investigation in the parameters space is reported...
  23. ncbi request reprint Localization and quantification of fluorescent inclusions embedded in a turbid medium
    Cosimo D'andrea
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Phys Med Biol 50:2313-27. 2005
    ..Finally, we studied the dependence of reconstructed data on the number of injection points of excitation light and the number of detection points of fluorescence emission...
  24. ncbi request reprint Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography study
    Valentina Quaresima
    University of L Aquila, Department of Biomedical Sciences and Technologies, I 67100 L Aquila, Italy
    J Biomed Opt 10:11012. 2005
    ..1+/-0.5%) compared to left side of the prefrontal cortex (0.9+/-0.5%) (P=0.005). A different pattern of cortical activation (characterized by the lack of HHb decrease or even increased HHb) was observed in the remaining subjects...
  25. doi request reprint Approach for non-destructive pigment analysis in model liquids and carrots by means of time-of-flight and multi-wavelength remittance readings
    Manuela Zude
    Leibniz Institute for Agricultural Engineering Potsdam Bornim ATB, Max Eyth Allee 100, 14469 Potsdam, Germany
    Anal Chim Acta 623:204-12. 2008
    ..In the sensor fusion approach proposed, however, no expensive spectrophotometer is required and the phenomenon of varying optical properties of the sample is characterized...