Research Topics
| Antonio PifferiSummaryAffiliation: Politecnico di Milano Country: Italy Publications
| Collaborators
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Detail Information
Publications
Absorption of collagen: effects on the estimate of breast composition and related diagnostic implicationsPaola Taroni
Politecnico di Milano, Dipartimento di Fisica, ULTRAS CNR INFM and IFN CNR, Piazza Leonardo da Vinci 32, I 20133 Milano, Italy
J Biomed Opt 12:014021. 2007..Adding collagen to the fitting procedure affects remarkably the estimated values of blood content and oxygenation. The quantification of collagen has potential implications for the assessment of breast density and cancer risk...- Time-resolved diffuse optical spectroscopy: a differential absorption approachPaola Taroni
Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
Appl Spectrosc 64:1220-6. 2010.... - Performance assessment of photon migration instruments: the MEDPHOT protocolAntonio Pifferi
Laboratorio Nazionale per l Ottica Ultra rapida e Ultra intensa, Dipartimento di Fisica e Istituto di Fotonicae Nanotecnologie, Consiglio Nazionale delle Ricerche, Politecnico di Milano, I 20133 Milan, Italy
Appl Opt 44:2104-14. 2005..This protocol was applied to a total of 8 instruments with a set of 32 phantoms, covering a wide range of optical properties... - Spectroscopic time-resolved diffuse reflectance and transmittance measurements of the female breast at different interfiber distancesAntonio Pifferi
Politecnico di Milano, ULTRAS INFM, INF CNR, Dipartimento di Fisica, P L da Vinci 32, I 20133, Milano, Italy
J Biomed Opt 9:1143-51. 2004..The intrasubject variations are larger for the scattering data than the absorption data; this is consistent with different spatial localization of the measurements of these parameters, which is explained by the photon migration theory... - Optical biopsy of bone tissue: a step toward the diagnosis of bone pathologiesAntonio Pifferi
ULTRAS INFM and IFN CNR, Dipartimento di Fisica Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
J Biomed Opt 9:474-80. 2004.... - Bulk optical properties and tissue components in the female breast from multiwavelength time-resolved optical mammographyLorenzo Spinelli
INFM, Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133, Milan, Italy
J Biomed Opt 9:1137-42. 2004..These results suggest that optical measurements on breasts can be exploited to obtain relevant information on breast tissue composition... - Characterization of female breast lesions from multi-wavelength time-resolved optical mammographyLorenzo Spinelli
INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
Phys Med Biol 50:2489-502. 2005..For fibroadenomas, the low number of cases does not allow any definite conclusions... - Fully automated time domain spectrometer for the absorption and scattering characterization of diffusive mediaAntonio Pifferi
ULTRAS CNR INFM and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
Rev Sci Instrum 78:053103. 2007..Finally, an example of application of the instrument to the spectroscopy of powders is presented... - In vivo time-resolved reflectance spectroscopy of the human foreheadDaniela Comelli
Centre of Ultrafast and Ultraintense Optical Science, Consiglio Nazionale delle Ricerche, Istituto Nazionale de Fisica della Materia, Politecnico di Milano, Milano, Italy
Appl Opt 46:1717-25. 2007..e., scalp and skull) than to deeper layer ones (white and gray matter). In particular, for the shorter interfiber distances, the recovered values can be assumed as a good estimate of the optical properties of the first layer... - Feasibility of white-light time-resolved optical mammographyAndrea Bassi
ULTRAS CNR INFM and CNR IFN, Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milano, Italy
J Biomed Opt 11:054035. 2006..Furthermore, measurements on a tissue-like sample demonstrate detection and characterization of inclusions... - Dynamic time-resolved diffuse spectroscopy based on supercontinuum light pulsesJohannes Swartling
ULTRAS INFM, IFN CNR, Dipartimento di Fisica, Politecnico di Milano, P L da Vinci 32, I 20133 Milano, Italy
Appl Opt 44:4684-92. 2005..We also present the first in vivo real-time dynamic spectral measurements showing tissue oxygenation changes in the arm of a human subject... 
Fast-gated single-photon counting technique widens dynamic range and speeds up acquisition time in time-resolved measurementsAlberto Tosi
Politecnico di Milano, Dipartimento di Elettronica e Informazione, Piazza Leonardo da Vinci 32, I 20133 Milano, Italy
Opt Express 19:10735-46. 2011..In experimental measurements, we obtained a dynamic range approaching 8 decades in few minutes of acquisition...- Time-resolved diffuse optical spectroscopy up to 1700 nm by means of a time-gated InGaAs/InP single-photon avalanche diodeIlaria Bargigia
Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milano, Italy
Appl Spectrosc 66:944-50. 2012..4 cm(-1) where the relative error is 17%. A first measurement performed on lipids is presented: the absorption spectrum shows three major peaks at 1200 nm, 1400 nm, and 1700 nm... - Mapping of calf muscle oxygenation and haemoglobin content during dynamic plantar flexion exercise by multi-channel time-resolved near-infrared spectroscopyAlessandro Torricelli
INFM-Dipartimento di Fisica and IFN-CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, 1-20133 Milan, Italy
Phys Med Biol 49:685-99. 2004..02). These results strengthen the role of time-resolved near-infrared spectroscopy as a powerful tool for investigating the spatial and temporal features of muscle SmO2 and tHb... - Time-resolved optical mammography between 637 and 985 nm: clinical study on the detection and identification of breast lesionsPaola Taroni
INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
Phys Med Biol 50:2469-88. 2005..The capacity to assess the density of breast based on the average scattering properties was also tested... 
Effects of tissue heterogeneity on the optical estimate of breast densityPaola Taroni
Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy
Biomed Opt Express 3:2411-8. 2012..A central position is optimal for the measurement, but its exact location is not critical...- Time-resolved scanning system for double reflectance and transmittance fluorescence imaging of diffusive mediaMarco Brambilla
IIT, ULTRAS INFM CNR and IFN CNR, Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
Rev Sci Instrum 79:013103. 2008..We finally discuss some of the criticalities of the proposed system and the developments we are currently carrying on in order to adapt it for in vivo measurements... - Diffuse optical spectroscopy of breast tissue extended to 1100 nmPaola Taroni
Politecnico di Milano, Dipartimento di Fisica and Consiglio Nazionale delle Ricerche, Istituto di Fotonica e Nanotecnologie, Piazza Leonardo da Vinci 32, Milan, 20133, Italy
J Biomed Opt 14:054030. 2009.... - Noninvasive assessment of breast cancer risk using time-resolved diffuse optical spectroscopyPaola Taroni
Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milano, Italy
J Biomed Opt 15:060501. 2010..A synthetic optical index proves to be quite effective in separating different breast density categories. Finally, the estimate of collagen content as a more direct means for the assessment of breast cancer risk is discussed... - Time-resolved spectrophotometer for turbid media based on supercontinuum generation in a photonic crystal fiberAndrea Bassi
National Laboratory for Ultrafast and Ultraintense Optical Science, I 20133 Milan, Italy
Opt Lett 29:2405-7. 2004..The results were similar to those obtained with previous discrete wavelength systems, whereas the full spectrum (610-810 nm) acquisition time was as short as 1 s owing to the parallel acquisition... - Clinical trial of time-resolved scanning optical mammography at 4 wavelengths between 683 and 975 nmPaola Taroni
Politecnico di Milano, INFM Dipartimento di Fisica, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
J Biomed Opt 9:464-73. 2004..The effectiveness of the technique in localizing and discriminating different lesion types is analyzed as a function of various parameters (lesion size, compressed breast thickness, and breast parenchymal pattern). ... - Absorption and scattering perturbations in homogeneous and layered diffusive media probed by time-resolved reflectance at null source-detector separationLorenzo Spinelli
INFM-Dipartimento di Fisica and IFN-CNR, Politecnico di Milano, Piazza L. da Vinci 32, I-20133 Milan, Italy
Phys Rev E Stat Nonlin Soft Matter Phys 74:021919. 2006..Exhaustive investigation in the parameters space is reported... - Time-resolved diffuse reflectance using small source-detector separation and fast single-photon gatingAntonio Pifferi
IIT, ULTRAS INFM CNR and IFN CNR, Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
Phys Rev Lett 100:138101. 2008..Finally, the proposed approach proved valuable to detect in vivo a task-related brain activation... - Four-wavelength time-resolved optical mammography in the 680-980-nm rangeAntonio Pifferi
Istituto Nazionale per la Fisica della Materia, Dipartimento di Fisica e Istituto di Fotonica e Nanotecnologie, Consiglio Nazionale delle Ricerche, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy
Opt Lett 28:1138-40. 2003..The system is currently used in a European clinical trial... - Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantificationPaola Taroni
Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
Opt Express 17:15932-46. 2009..Then images were collected at 7 wavelengths (635-1060 nm) from 10 healthy volunteers. Average collagen content correlated with breast density whenever x-ray mammograms were available (6 subjects)... - In vivo absorption and scattering spectroscopy of biological tissuesPaola Taroni
INFM-Dipartimento di Fisica and IFN-CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy
Photochem Photobiol Sci 2:124-9. 2003..Finally, an example of the applicability of the methodology to other biological media such as fruits and vegetables is shown... - Experimental test of a perturbation model for time-resolved imaging in diffusive mediaLorenzo Spinelli
Istituto Nazionale per la Fisica della Materia, Dipartimento di Fisica and Centro di Elettronica Quantistica e Strumentazione Elettronica, Consiglo Nazionale delle Ricerche, Politecnico di Milano, Piazza Leonardo da Vinci 32, 1 20133 Milan, Italy
Appl Opt 42:3145-53. 2003.... - Absorption spectroscopy of powdered materials using time-resolved diffuse optical methodsCosimo D'andrea
Dipartimento di Fisica, Politecnico di Milano, Milan, Italy
Appl Opt 51:7858-63. 2012..The comparison between the absorption spectra acquired by the proposed method and conventional measurements performed with a commercial spectrophotometer is discussed... - In vivo measurement of vascular modulation in experimental tumors using a fluorescent contrast agentGianluca Valentini
IIT, ULTRAS CNR INFM and IFN CNR, Dipartimento di Fisica, Politecnico di Milano, Milan, Italy
Photochem Photobiol 84:1249-56. 2008..However, ICG fluorescence measured with the TCSPC apparatus in transmittance geometry and the estimate of the change in optical absorption did not allow a statistically significant differentiation between treated and control groups... - Light propagation in dry and wet softwoodAlwin Kienle
Institut fur Lasertechnologien in der Medizin und Messtechnik, Helmholtzstr 12, D 89081 Ulm, Germany
Opt Express 16:9895-906. 2008..Good qualitative agreement was obtained between the experimentally and theoretically derived optical properties... - Determination of the optical properties of anisotropic biological media using an isotropic diffusion modelAlwin Kienle
Institut fur Lasertechnologien in der Medizin und Messtechnik, Helmholtzstrasse 12, D 89081 Ulm, Germany
J Biomed Opt 12:014026. 2007..Contrarily, the derived reduced scattering coefficient depends strongly on the measurement direction in both domains. Measurements of the steady-state and time-resolved reflectance from bovine tendon confirm the theoretical findings... - Phantom validation and in vivo application of an inversion procedure for retrieving the optical properties of diffusive layered media from time-resolved reflectance measurementsFabrizio Martelli
Dipartimento di Fisica dell Università degli Studi di Firenze and Istituto Nazionale per la Fisica della Materia, Via G Sansone 1, 50019 Sesto Fiorentino, Florence, Italy
Opt Lett 29:2037-9. 2004..The first layer thickness could be retrieved with an error less than 50%. An example of retrieval of the optical properties of muscle from in vivo measurements during an arterial occlusion is shown... - Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography studyValentina Quaresima
University of L Aquila, Department of Biomedical Sciences and Technologies, I 67100 L Aquila, Italy
J Biomed Opt 10:11012. 2005..1+/-0.5%) compared to left side of the prefrontal cortex (0.9+/-0.5%) (P=0.005). A different pattern of cortical activation (characterized by the lack of HHb decrease or even increased HHb) was observed in the remaining subjects... - In vivo absorption spectroscopy of tumor sensitizers with femtosecond white lightClaes af Klinteberg
Department of Physics, Lund Institute of Technology, Lund S-221 00, Sweden
Appl Opt 44:2213-20. 2005..Thus the contrast in the drug-related absorption can be altered by up to a factor of 2 from the primary drug molecular-concentration contrast between normal muscle and tumor by the proper selection of the illumination wavelength...