Antonio Pifferi

Summary

Affiliation: Politecnico di Milano
Country: Italy

Publications

  1. ncbi request reprint Absorption of collagen: effects on the estimate of breast composition and related diagnostic implications
    Paola Taroni
    Politecnico di Milano, Dipartimento di Fisica, ULTRAS CNR INFM and IFN CNR, Piazza Leonardo da Vinci 32, I 20133 Milano, Italy
    J Biomed Opt 12:014021. 2007
  2. ncbi request reprint Time-resolved diffuse optical spectroscopy: a differential absorption approach
    Paola Taroni
    Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
    Appl Spectrosc 64:1220-6. 2010
  3. ncbi request reprint Performance assessment of photon migration instruments: the MEDPHOT protocol
    Antonio Pifferi
    Laboratorio Nazionale per l Ottica Ultra rapida e Ultra intensa, Dipartimento di Fisica e Istituto di Fotonicae Nanotecnologie, Consiglio Nazionale delle Ricerche, Politecnico di Milano, I 20133 Milan, Italy
    Appl Opt 44:2104-14. 2005
  4. ncbi request reprint Spectroscopic time-resolved diffuse reflectance and transmittance measurements of the female breast at different interfiber distances
    Antonio Pifferi
    Politecnico di Milano, ULTRAS INFM, INF CNR, Dipartimento di Fisica, P L da Vinci 32, I 20133, Milano, Italy
    J Biomed Opt 9:1143-51. 2004
  5. ncbi request reprint Optical biopsy of bone tissue: a step toward the diagnosis of bone pathologies
    Antonio Pifferi
    ULTRAS INFM and IFN CNR, Dipartimento di Fisica Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    J Biomed Opt 9:474-80. 2004
  6. ncbi request reprint In vivo time-resolved reflectance spectroscopy of the human forehead
    Daniela Comelli
    Centre of Ultrafast and Ultraintense Optical Science, Consiglio Nazionale delle Ricerche, Istituto Nazionale de Fisica della Materia, Politecnico di Milano, Milano, Italy
    Appl Opt 46:1717-25. 2007
  7. ncbi request reprint Characterization of female breast lesions from multi-wavelength time-resolved optical mammography
    Lorenzo Spinelli
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Phys Med Biol 50:2489-502. 2005
  8. ncbi request reprint Fully automated time domain spectrometer for the absorption and scattering characterization of diffusive media
    Antonio Pifferi
    ULTRAS CNR INFM and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Rev Sci Instrum 78:053103. 2007
  9. ncbi request reprint Bulk optical properties and tissue components in the female breast from multiwavelength time-resolved optical mammography
    Lorenzo Spinelli
    INFM, Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133, Milan, Italy
    J Biomed Opt 9:1137-42. 2004
  10. doi request reprint Optical identification of subjects at high risk for developing breast cancer
    Paola Taroni
    Politecnico di Milano, Dipartimento di Fisica, Milano, Italy
    J Biomed Opt 18:060507. 2013

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Absorption of collagen: effects on the estimate of breast composition and related diagnostic implications
    Paola Taroni
    Politecnico di Milano, Dipartimento di Fisica, ULTRAS CNR INFM and IFN CNR, Piazza Leonardo da Vinci 32, I 20133 Milano, Italy
    J Biomed Opt 12:014021. 2007
    ..Adding collagen to the fitting procedure affects remarkably the estimated values of blood content and oxygenation. The quantification of collagen has potential implications for the assessment of breast density and cancer risk...
  2. ncbi request reprint Time-resolved diffuse optical spectroscopy: a differential absorption approach
    Paola Taroni
    Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
    Appl Spectrosc 64:1220-6. 2010
    ....
  3. ncbi request reprint Performance assessment of photon migration instruments: the MEDPHOT protocol
    Antonio Pifferi
    Laboratorio Nazionale per l Ottica Ultra rapida e Ultra intensa, Dipartimento di Fisica e Istituto di Fotonicae Nanotecnologie, Consiglio Nazionale delle Ricerche, Politecnico di Milano, I 20133 Milan, Italy
    Appl Opt 44:2104-14. 2005
    ..This protocol was applied to a total of 8 instruments with a set of 32 phantoms, covering a wide range of optical properties...
  4. ncbi request reprint Spectroscopic time-resolved diffuse reflectance and transmittance measurements of the female breast at different interfiber distances
    Antonio Pifferi
    Politecnico di Milano, ULTRAS INFM, INF CNR, Dipartimento di Fisica, P L da Vinci 32, I 20133, Milano, Italy
    J Biomed Opt 9:1143-51. 2004
    ..The intrasubject variations are larger for the scattering data than the absorption data; this is consistent with different spatial localization of the measurements of these parameters, which is explained by the photon migration theory...
  5. ncbi request reprint Optical biopsy of bone tissue: a step toward the diagnosis of bone pathologies
    Antonio Pifferi
    ULTRAS INFM and IFN CNR, Dipartimento di Fisica Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    J Biomed Opt 9:474-80. 2004
    ....
  6. ncbi request reprint In vivo time-resolved reflectance spectroscopy of the human forehead
    Daniela Comelli
    Centre of Ultrafast and Ultraintense Optical Science, Consiglio Nazionale delle Ricerche, Istituto Nazionale de Fisica della Materia, Politecnico di Milano, Milano, Italy
    Appl Opt 46:1717-25. 2007
    ..e., scalp and skull) than to deeper layer ones (white and gray matter). In particular, for the shorter interfiber distances, the recovered values can be assumed as a good estimate of the optical properties of the first layer...
  7. ncbi request reprint Characterization of female breast lesions from multi-wavelength time-resolved optical mammography
    Lorenzo Spinelli
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Phys Med Biol 50:2489-502. 2005
    ..For fibroadenomas, the low number of cases does not allow any definite conclusions...
  8. ncbi request reprint Fully automated time domain spectrometer for the absorption and scattering characterization of diffusive media
    Antonio Pifferi
    ULTRAS CNR INFM and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Rev Sci Instrum 78:053103. 2007
    ..Finally, an example of application of the instrument to the spectroscopy of powders is presented...
  9. ncbi request reprint Bulk optical properties and tissue components in the female breast from multiwavelength time-resolved optical mammography
    Lorenzo Spinelli
    INFM, Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133, Milan, Italy
    J Biomed Opt 9:1137-42. 2004
    ..These results suggest that optical measurements on breasts can be exploited to obtain relevant information on breast tissue composition...
  10. doi request reprint Optical identification of subjects at high risk for developing breast cancer
    Paola Taroni
    Politecnico di Milano, Dipartimento di Fisica, Milano, Italy
    J Biomed Opt 18:060507. 2013
    ..The model presents a total misclassification error of 12.3%, sensitivity of 69%, specificity of 94%, and simple kappa of 0.84, which compares favorably even with intraradiologist assignments of BI-RADS categories...
  11. ncbi request reprint Feasibility of white-light time-resolved optical mammography
    Andrea Bassi
    ULTRAS CNR INFM and CNR IFN, Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milano, Italy
    J Biomed Opt 11:054035. 2006
    ..Furthermore, measurements on a tissue-like sample demonstrate detection and characterization of inclusions...
  12. ncbi request reprint Dynamic time-resolved diffuse spectroscopy based on supercontinuum light pulses
    Johannes Swartling
    ULTRAS INFM, IFN CNR, Dipartimento di Fisica, Politecnico di Milano, P L da Vinci 32, I 20133 Milano, Italy
    Appl Opt 44:4684-92. 2005
    ..We also present the first in vivo real-time dynamic spectral measurements showing tissue oxygenation changes in the arm of a human subject...
  13. doi request reprint Recipes to make organic phantoms for diffusive optical spectroscopy
    Giovanna Quarto
    Politecnico di Milano, Dipartimento di Fisica, Milano 20133, Italy
    Appl Opt 52:2494-502. 2013
    ..6% and 1.5% for the absorption and reduced scattering coefficient, respectively] and good reproducibility (CV of 8.3% and 12.4% for absorption and reduced scattering coefficient, respectively)...
  14. doi request reprint Fast-gated single-photon counting technique widens dynamic range and speeds up acquisition time in time-resolved measurements
    Alberto Tosi
    Politecnico di Milano, Dipartimento di Elettronica e Informazione, Piazza Leonardo da Vinci 32, I 20133 Milano, Italy
    Opt Express 19:10735-46. 2011
    ..In experimental measurements, we obtained a dynamic range approaching 8 decades in few minutes of acquisition...
  15. doi request reprint Time-resolved diffuse optical spectroscopy up to 1700 nm by means of a time-gated InGaAs/InP single-photon avalanche diode
    Ilaria Bargigia
    Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milano, Italy
    Appl Spectrosc 66:944-50. 2012
    ..4 cm(-1) where the relative error is 17%. A first measurement performed on lipids is presented: the absorption spectrum shows three major peaks at 1200 nm, 1400 nm, and 1700 nm...
  16. ncbi request reprint Mapping of calf muscle oxygenation and haemoglobin content during dynamic plantar flexion exercise by multi-channel time-resolved near-infrared spectroscopy
    Alessandro Torricelli
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, 1 20133 Milan, Italy
    Phys Med Biol 49:685-99. 2004
    ..02). These results strengthen the role of time-resolved near-infrared spectroscopy as a powerful tool for investigating the spatial and temporal features of muscle SmO2 and tHb...
  17. ncbi request reprint Time-resolved optical mammography between 637 and 985 nm: clinical study on the detection and identification of breast lesions
    Paola Taroni
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Phys Med Biol 50:2469-88. 2005
    ..The capacity to assess the density of breast based on the average scattering properties was also tested...
  18. pmc Effects of tissue heterogeneity on the optical estimate of breast density
    Paola Taroni
    Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy
    Biomed Opt Express 3:2411-8. 2012
    ..A central position is optimal for the measurement, but its exact location is not critical...
  19. doi request reprint Diffuse optical spectroscopy of breast tissue extended to 1100 nm
    Paola Taroni
    Politecnico di Milano, Dipartimento di Fisica and Consiglio Nazionale delle Ricerche, Istituto di Fotonica e Nanotecnologie, Piazza Leonardo da Vinci 32, Milan, 20133, Italy
    J Biomed Opt 14:054030. 2009
    ....
  20. doi request reprint Noninvasive assessment of breast cancer risk using time-resolved diffuse optical spectroscopy
    Paola Taroni
    Dipartimento di Fisica, Piazza Leonardo da Vinci 32, 20133 Milano, Italy
    J Biomed Opt 15:060501. 2010
    ..A synthetic optical index proves to be quite effective in separating different breast density categories. Finally, the estimate of collagen content as a more direct means for the assessment of breast cancer risk is discussed...
  21. doi request reprint Time-resolved scanning system for double reflectance and transmittance fluorescence imaging of diffusive media
    Marco Brambilla
    IIT, ULTRAS INFM CNR and IFN CNR, Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Rev Sci Instrum 79:013103. 2008
    ..We finally discuss some of the criticalities of the proposed system and the developments we are currently carrying on in order to adapt it for in vivo measurements...
  22. ncbi request reprint Clinical trial of time-resolved scanning optical mammography at 4 wavelengths between 683 and 975 nm
    Paola Taroni
    Politecnico di Milano, INFM Dipartimento di Fisica, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    J Biomed Opt 9:464-73. 2004
    ..The effectiveness of the technique in localizing and discriminating different lesion types is analyzed as a function of various parameters (lesion size, compressed breast thickness, and breast parenchymal pattern). ...
  23. ncbi request reprint Time-resolved spectrophotometer for turbid media based on supercontinuum generation in a photonic crystal fiber
    Andrea Bassi
    National Laboratory for Ultrafast and Ultraintense Optical Science, I 20133 Milan, Italy
    Opt Lett 29:2405-7. 2004
    ..The results were similar to those obtained with previous discrete wavelength systems, whereas the full spectrum (610-810 nm) acquisition time was as short as 1 s owing to the parallel acquisition...
  24. ncbi request reprint Time-resolved diffuse reflectance using small source-detector separation and fast single-photon gating
    Antonio Pifferi
    IIT, ULTRAS INFM CNR and IFN CNR, Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Phys Rev Lett 100:138101. 2008
    ..Finally, the proposed approach proved valuable to detect in vivo a task-related brain activation...
  25. ncbi request reprint Absorption and scattering perturbations in homogeneous and layered diffusive media probed by time-resolved reflectance at null source-detector separation
    Lorenzo Spinelli
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza L da Vinci 32, I 20133 Milan, Italy
    Phys Rev E Stat Nonlin Soft Matter Phys 74:021919. 2006
    ..Exhaustive investigation in the parameters space is reported...
  26. doi request reprint Absorption spectroscopy of powdered materials using time-resolved diffuse optical methods
    Cosimo D'andrea
    Dipartimento di Fisica, Politecnico di Milano, Milan, Italy
    Appl Opt 51:7858-63. 2012
    ..The comparison between the absorption spectra acquired by the proposed method and conventional measurements performed with a commercial spectrophotometer is discussed...
  27. ncbi request reprint Four-wavelength time-resolved optical mammography in the 680-980-nm range
    Antonio Pifferi
    Istituto Nazionale per la Fisica della Materia, Dipartimento di Fisica e Istituto di Fotonica e Nanotecnologie, Consiglio Nazionale delle Ricerche, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Opt Lett 28:1138-40. 2003
    ..The system is currently used in a European clinical trial...
  28. doi request reprint Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantification
    Paola Taroni
    Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
    Opt Express 17:15932-46. 2009
    ..Then images were collected at 7 wavelengths (635-1060 nm) from 10 healthy volunteers. Average collagen content correlated with breast density whenever x-ray mammograms were available (6 subjects)...
  29. ncbi request reprint Experimental test of a perturbation model for time-resolved imaging in diffusive media
    Lorenzo Spinelli
    Istituto Nazionale per la Fisica della Materia, Dipartimento di Fisica and Centro di Elettronica Quantistica e Strumentazione Elettronica, Consiglo Nazionale delle Ricerche, Politecnico di Milano, Piazza Leonardo da Vinci 32, 1 20133 Milan, Italy
    Appl Opt 42:3145-53. 2003
    ....
  30. ncbi request reprint In vivo absorption and scattering spectroscopy of biological tissues
    Paola Taroni
    INFM Dipartimento di Fisica and IFN CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I 20133 Milan, Italy
    Photochem Photobiol Sci 2:124-9. 2003
    ..Finally, an example of the applicability of the methodology to other biological media such as fruits and vegetables is shown...
  31. doi request reprint Time domain functional NIRS imaging for human brain mapping
    Alessandro Torricelli
    Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, I 20133, Milan, Italy Electronic address
    Neuroimage 85:28-50. 2014
    ..Finally we give an account on the technological developments that would pave the way for a broader use of TD fNIRS in the neuroimaging community. ..
  32. doi request reprint In vivo measurement of vascular modulation in experimental tumors using a fluorescent contrast agent
    Gianluca Valentini
    IIT, ULTRAS CNR INFM and IFN CNR, Dipartimento di Fisica, Politecnico di Milano, Milan, Italy
    Photochem Photobiol 84:1249-56. 2008
    ..However, ICG fluorescence measured with the TCSPC apparatus in transmittance geometry and the estimate of the change in optical absorption did not allow a statistically significant differentiation between treated and control groups...
  33. ncbi request reprint Phantom validation and in vivo application of an inversion procedure for retrieving the optical properties of diffusive layered media from time-resolved reflectance measurements
    Fabrizio Martelli
    Dipartimento di Fisica dell Università degli Studi di Firenze and Istituto Nazionale per la Fisica della Materia, Via G Sansone 1, 50019 Sesto Fiorentino, Florence, Italy
    Opt Lett 29:2037-9. 2004
    ..The first layer thickness could be retrieved with an error less than 50%. An example of retrieval of the optical properties of muscle from in vivo measurements during an arterial occlusion is shown...
  34. ncbi request reprint Determination of the optical properties of anisotropic biological media using an isotropic diffusion model
    Alwin Kienle
    Institut fur Lasertechnologien in der Medizin und Messtechnik, Helmholtzstrasse 12, D 89081 Ulm, Germany
    J Biomed Opt 12:014026. 2007
    ..Contrarily, the derived reduced scattering coefficient depends strongly on the measurement direction in both domains. Measurements of the steady-state and time-resolved reflectance from bovine tendon confirm the theoretical findings...
  35. ncbi request reprint Light propagation in dry and wet softwood
    Alwin Kienle
    Institut fur Lasertechnologien in der Medizin und Messtechnik, Helmholtzstr 12, D 89081 Ulm, Germany
    Opt Express 16:9895-906. 2008
    ..Good qualitative agreement was obtained between the experimentally and theoretically derived optical properties...
  36. ncbi request reprint In vivo absorption spectroscopy of tumor sensitizers with femtosecond white light
    Claes af Klinteberg
    Department of Physics, Lund Institute of Technology, Lund S 221 00, Sweden
    Appl Opt 44:2213-20. 2005
    ..Thus the contrast in the drug-related absorption can be altered by up to a factor of 2 from the primary drug molecular-concentration contrast between normal muscle and tumor by the proper selection of the illumination wavelength...
  37. ncbi request reprint Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography study
    Valentina Quaresima
    University of L Aquila, Department of Biomedical Sciences and Technologies, I 67100 L Aquila, Italy
    J Biomed Opt 10:11012. 2005
    ..1+/-0.5%) compared to left side of the prefrontal cortex (0.9+/-0.5%) (P=0.005). A different pattern of cortical activation (characterized by the lack of HHb decrease or even increased HHb) was observed in the remaining subjects...