Affiliation: Politecnico di Bari
- A theoretical model for the margination of particles within blood vesselsP Decuzzi
Center of Excellence in Computational Mechanics, Politecnico di Bari, Bari 70125, Italy
Ann Biomed Eng 33:179-90. 2005..While particles used as nanoharvesting agents in proteomics or genomics analysis should have a radius close to the critical value to minimize margination and increase their circulation time...
- The adhesive strength of non-spherical particles mediated by specific interactionsP Decuzzi
Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia, 88100 Catanzaro, Italy
Biomaterials 27:5307-14. 2006..The formulae and the procedures described in the present work can guide the optimal design of intravascularly injectable micro/nano carriers...
- Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applicationsEnnio Tasciotti
Nat Nanotechnol 3:151-7. 2008..The use of this system is envisioned to open new avenues for avoiding biological barriers and delivering more than one therapeutic agent to the target at a time, in a time-controlled fashion...
- Adhesion of microfabricated particles on vascular endothelium: a parametric analysisPaolo Decuzzi
Center of Excellence in Computational Mechanics, Politecnico di Bari, Bari, Italy
Ann Biomed Eng 32:793-802. 2004..Criteria for the optimal design of particles are proposed...
- The effective dispersion of nanovectors within the tumor microvasculatureP Decuzzi
Center of Bio Nanotechnology and Bio Engineering for Medicine, University of Magna Graecia, Catanzaro, 88100, Italy
Ann Biomed Eng 34:633-41. 2006..Finally, it has been emphasized that the size of the vector should be selected depending on the body district where the tumoral mass is developing and on the type, malignancy, and state of the tumor...
- The role of specific and non-specific interactions in receptor-mediated endocytosis of nanoparticlesP Decuzzi
BioNEM Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia, Viale Europa Loc Germaneto 88100 Catanzaro, Italy
Biomaterials 28:2915-22. 2007..It is shown that the contribution of F is as important as that of C and G. General and ready to use formulas are presented that can be a guide in designing nanoparticles with controlled endocytic performances...
- Flow chamber analysis of size effects in the adhesion of spherical particlesP Decuzzi
Center of Bio Nanotechnology and Engineering for Medicine University of Magna Graecia at Catanzaro, Viale Europa Loc Germaneto, Catanzaro, Italy
Int J Nanomedicine 2:689-96. 2007..3). From these results and considering solely non-specific particles, the following hypothesis are generated (i) use the smallest possible particles in biomedical imaging and (ii) use the largest possible particles in drug delivery...
- Design maps for nanoparticles targeting the diseased microvasculaturePaolo Decuzzi
BioNEM Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia, Viale Europa Loc Germaneto, 88100 Catanzaro, Italy
Biomaterials 29:377-84. 2008....
- The transport of nanoparticles in blood vessels: the effect of vessel permeability and blood rheologyFrancesco Gentile
Center of Bio Nanotechnology and Engineering for Medicine BioNEM, University of Magna Graecia at Catanzaro, Viale Europa Loc Germaneto, 88100 Catanzaro, Italy
Ann Biomed Eng 36:254-61. 2008..An increase of xi(c) or pi has the effect of reducing Deff, and thus both the rheology of blood and the permeability of the vessels may constitute a physiological barrier to the intravascular delivery of nanoparticles...
- The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flowsF Gentile
BioNEM Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia at Catanzaro, Viale Europa, loc Germaneto, 88100 Catanzaro, Italy
J Biomech 41:2312-8. 2008..These results may be of interest in drug delivery and bio-imaging applications, where particles are expected to drift towards and interact with the walls of the blood vessels...
- The preferential targeting of the diseased microvasculature by disk-like particlesGiulia Adriani
Department of Mechanical and Management Engineering, Politecnico di Bari, Bari, Italy
Biomaterials 33:5504-13. 2012..In view of the growing evidence on vascular molecular heterogeneity, the present data suggests that thin disk-like particles could more effectively target the diseased microvasculature as compared to spheres and slender rods...
- Selective modulation of cell response on engineered fractal silicon substratesFrancesco Gentile
BioNEM Center of BioNanotechnology and Engineering for Medicine, University of Magna Graecia, Italy
Sci Rep 3:1461. 2013..2). Higher proliferation occurson substrates exhibiting densely packed and sharp peaks, whereas more regular ridges favor adhesion. These results suggest that randomly roughtopographies can selectively modulate cell behavior...
- The receptor-mediated endocytosis of nonspherical particlesP Decuzzi
Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia, Catanzaro, Italy
Biophys J 94:3790-7. 2008..Given the pleomorphism of viruses and the broad spectrum of shapes for nanosized biomimetic particles, the results presented may be of interest to virologists, pharmacologists, toxicologists, and nanotechnologists...
- The margination propensity of spherical particles for vascular targeting in the microcirculationFrancesco Gentile
Center of Bio Nanotechnology and Engineering for Medicine University of Magna Graecia at Catanzaro, Viale Europa Loc, Germaneto, 88100, Catanzaro, Italy
J Nanobiotechnology 6:9. 2008....
- Antibiological barrier nanovector technology for cancer applicationsJason Sakamoto
Alliance for NanoHealth, 1825 Herman Pressler Street, Suite 537A, Houston, Texas 77030, USA
Expert Opin Drug Deliv 4:359-69. 2007..This novel, multi-stage strategy enables efficient localised delivery of chemotoxic drugs that may lead to significant improvements in therapy efficacy, reduced systemic toxicity and decreased total amount of injected drugs...