Paolo Decuzzi

Summary

Affiliation: Politecnico di Bari
Country: Italy

Publications

  1. ncbi request reprint A theoretical model for the margination of particles within blood vessels
    P Decuzzi
    Center of Excellence in Computational Mechanics, Politecnico di Bari, Bari 70125, Italy
    Ann Biomed Eng 33:179-90. 2005
  2. ncbi request reprint The adhesive strength of non-spherical particles mediated by specific interactions
    P Decuzzi
    Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia, 88100 Catanzaro, Italy
    Biomaterials 27:5307-14. 2006
  3. doi request reprint Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications
    Ennio Tasciotti
    Nat Nanotechnol 3:151-7. 2008
  4. ncbi request reprint Adhesion of microfabricated particles on vascular endothelium: a parametric analysis
    Paolo Decuzzi
    Center of Excellence in Computational Mechanics, Politecnico di Bari, Bari, Italy
    Ann Biomed Eng 32:793-802. 2004
  5. ncbi request reprint The effective dispersion of nanovectors within the tumor microvasculature
    P Decuzzi
    Center of Bio Nanotechnology and Bio Engineering for Medicine, University of Magna Graecia, Catanzaro, 88100, Italy
    Ann Biomed Eng 34:633-41. 2006
  6. ncbi request reprint The role of specific and non-specific interactions in receptor-mediated endocytosis of nanoparticles
    P Decuzzi
    BioNEM Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia, Viale Europa Loc Germaneto 88100 Catanzaro, Italy
    Biomaterials 28:2915-22. 2007
  7. pmc Flow chamber analysis of size effects in the adhesion of spherical particles
    P Decuzzi
    Center of Bio Nanotechnology and Engineering for Medicine University of Magna Graecia at Catanzaro, Viale Europa Loc Germaneto, Catanzaro, Italy
    Int J Nanomedicine 2:689-96. 2007
  8. ncbi request reprint Design maps for nanoparticles targeting the diseased microvasculature
    Paolo Decuzzi
    BioNEM Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia, Viale Europa Loc Germaneto, 88100 Catanzaro, Italy
    Biomaterials 29:377-84. 2008
  9. doi request reprint The transport of nanoparticles in blood vessels: the effect of vessel permeability and blood rheology
    Francesco Gentile
    Center of Bio Nanotechnology and Engineering for Medicine BioNEM, University of Magna Graecia at Catanzaro, Viale Europa Loc Germaneto, 88100 Catanzaro, Italy
    Ann Biomed Eng 36:254-61. 2008
  10. doi request reprint The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows
    F Gentile
    BioNEM Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia at Catanzaro, Viale Europa, loc Germaneto, 88100 Catanzaro, Italy
    J Biomech 41:2312-8. 2008

Collaborators

Detail Information

Publications15

  1. ncbi request reprint A theoretical model for the margination of particles within blood vessels
    P Decuzzi
    Center of Excellence in Computational Mechanics, Politecnico di Bari, Bari 70125, Italy
    Ann Biomed Eng 33:179-90. 2005
    ..While particles used as nanoharvesting agents in proteomics or genomics analysis should have a radius close to the critical value to minimize margination and increase their circulation time...
  2. ncbi request reprint The adhesive strength of non-spherical particles mediated by specific interactions
    P Decuzzi
    Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia, 88100 Catanzaro, Italy
    Biomaterials 27:5307-14. 2006
    ..The formulae and the procedures described in the present work can guide the optimal design of intravascularly injectable micro/nano carriers...
  3. doi request reprint Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications
    Ennio Tasciotti
    Nat Nanotechnol 3:151-7. 2008
    ..The use of this system is envisioned to open new avenues for avoiding biological barriers and delivering more than one therapeutic agent to the target at a time, in a time-controlled fashion...
  4. ncbi request reprint Adhesion of microfabricated particles on vascular endothelium: a parametric analysis
    Paolo Decuzzi
    Center of Excellence in Computational Mechanics, Politecnico di Bari, Bari, Italy
    Ann Biomed Eng 32:793-802. 2004
    ..Criteria for the optimal design of particles are proposed...
  5. ncbi request reprint The effective dispersion of nanovectors within the tumor microvasculature
    P Decuzzi
    Center of Bio Nanotechnology and Bio Engineering for Medicine, University of Magna Graecia, Catanzaro, 88100, Italy
    Ann Biomed Eng 34:633-41. 2006
    ..Finally, it has been emphasized that the size of the vector should be selected depending on the body district where the tumoral mass is developing and on the type, malignancy, and state of the tumor...
  6. ncbi request reprint The role of specific and non-specific interactions in receptor-mediated endocytosis of nanoparticles
    P Decuzzi
    BioNEM Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia, Viale Europa Loc Germaneto 88100 Catanzaro, Italy
    Biomaterials 28:2915-22. 2007
    ..It is shown that the contribution of F is as important as that of C and G. General and ready to use formulas are presented that can be a guide in designing nanoparticles with controlled endocytic performances...
  7. pmc Flow chamber analysis of size effects in the adhesion of spherical particles
    P Decuzzi
    Center of Bio Nanotechnology and Engineering for Medicine University of Magna Graecia at Catanzaro, Viale Europa Loc Germaneto, Catanzaro, Italy
    Int J Nanomedicine 2:689-96. 2007
    ..3). From these results and considering solely non-specific particles, the following hypothesis are generated (i) use the smallest possible particles in biomedical imaging and (ii) use the largest possible particles in drug delivery...
  8. ncbi request reprint Design maps for nanoparticles targeting the diseased microvasculature
    Paolo Decuzzi
    BioNEM Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia, Viale Europa Loc Germaneto, 88100 Catanzaro, Italy
    Biomaterials 29:377-84. 2008
    ....
  9. doi request reprint The transport of nanoparticles in blood vessels: the effect of vessel permeability and blood rheology
    Francesco Gentile
    Center of Bio Nanotechnology and Engineering for Medicine BioNEM, University of Magna Graecia at Catanzaro, Viale Europa Loc Germaneto, 88100 Catanzaro, Italy
    Ann Biomed Eng 36:254-61. 2008
    ..An increase of xi(c) or pi has the effect of reducing Deff, and thus both the rheology of blood and the permeability of the vessels may constitute a physiological barrier to the intravascular delivery of nanoparticles...
  10. doi request reprint The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows
    F Gentile
    BioNEM Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia at Catanzaro, Viale Europa, loc Germaneto, 88100 Catanzaro, Italy
    J Biomech 41:2312-8. 2008
    ..These results may be of interest in drug delivery and bio-imaging applications, where particles are expected to drift towards and interact with the walls of the blood vessels...
  11. pmc The preferential targeting of the diseased microvasculature by disk-like particles
    Giulia Adriani
    Department of Mechanical and Management Engineering, Politecnico di Bari, Bari, Italy
    Biomaterials 33:5504-13. 2012
    ..In view of the growing evidence on vascular molecular heterogeneity, the present data suggests that thin disk-like particles could more effectively target the diseased microvasculature as compared to spheres and slender rods...
  12. pmc Selective modulation of cell response on engineered fractal silicon substrates
    Francesco Gentile
    BioNEM Center of BioNanotechnology and Engineering for Medicine, University of Magna Graecia, Italy
    Sci Rep 3:1461. 2013
    ..2). Higher proliferation occurson substrates exhibiting densely packed and sharp peaks, whereas more regular ridges favor adhesion. These results suggest that randomly roughtopographies can selectively modulate cell behavior...
  13. pmc The receptor-mediated endocytosis of nonspherical particles
    P Decuzzi
    Center of Bio Nanotechnology and Engineering for Medicine, University of Magna Graecia, Catanzaro, Italy
    Biophys J 94:3790-7. 2008
    ..Given the pleomorphism of viruses and the broad spectrum of shapes for nanosized biomimetic particles, the results presented may be of interest to virologists, pharmacologists, toxicologists, and nanotechnologists...
  14. pmc The margination propensity of spherical particles for vascular targeting in the microcirculation
    Francesco Gentile
    Center of Bio Nanotechnology and Engineering for Medicine University of Magna Graecia at Catanzaro, Viale Europa Loc, Germaneto, 88100, Catanzaro, Italy
    J Nanobiotechnology 6:9. 2008
    ....
  15. ncbi request reprint Antibiological barrier nanovector technology for cancer applications
    Jason Sakamoto
    Alliance for NanoHealth, 1825 Herman Pressler Street, Suite 537A, Houston, Texas 77030, USA
    Expert Opin Drug Deliv 4:359-69. 2007
    ..This novel, multi-stage strategy enables efficient localised delivery of chemotoxic drugs that may lead to significant improvements in therapy efficacy, reduced systemic toxicity and decreased total amount of injected drugs...