A Pilotto

Summary

Country: Italy

Publications

  1. ncbi request reprint The risk of upper gastrointestinal bleeding in elderly users of aspirin and other non-steroidal anti-inflammatory drugs: the role of gastroprotective drugs
    Alberto Pilotto
    Division of Geriatrics, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo Foggia, Italy
    Aging Clin Exp Res 15:494-9. 2003
  2. ncbi request reprint Review article: an approach to Helicobacter pylori infection in the elderly
    A Pilotto
    Department of Geriatrics, Digestive Pathophysiology Centre for the Elderly, San Bortolo Hospital, Vicenza, Italy
    Aliment Pharmacol Ther 16:683-91. 2002
  3. ncbi request reprint Drug use by the elderly in general practice: effects on upper gastrointestinal symptoms
    Alberto Pilotto
    Geriatric Unit, Casa Sollievo della Sofferenza, IRCCS, 71013, San Giovanni Rotondo, Italy
    Eur J Clin Pharmacol 62:65-73. 2006
  4. ncbi request reprint Long-term clinical outcome of elderly patients with reflux esophagitis: a six-month to three-year follow-up study
    Alberto Pilotto
    Digestive Pathophysiology Center for the Elderly, Dept of Geriatrics, Vicenza, Italy
    Am J Ther 9:295-300. 2002
  5. ncbi request reprint Influence of Helicobacter pylori infection on severity of oesophagitis and response to therapy in the elderly
    A Pilotto
    Digestive Pathophysiology Centre, Geriatric Division, San Bortolo Hospital, Vicenza, Italy
    Dig Liver Dis 34:328-31. 2002
  6. ncbi request reprint Helicobacter pylori infection in geriatrics
    Alberto Pilotto
    Fisiopatologia Digestiva dell Anziano, UO Geriatria, Ospedale San Bortolo, Vicenza, Italy
    Helicobacter 7:56-62. 2002
  7. ncbi request reprint Recent advances in the treatment of GERD in the elderly: focus on proton pump inhibitors
    A Pilotto
    IRCCS, Casa Sollievo della Sofferenza, Istituto di Ricovero e Cura a Carattere Scientifico, San Giovanni Rotondo, Italy
    Int J Clin Pract 59:1204-9. 2005
  8. ncbi request reprint Short- and long-term therapy for reflux oesophagitis in the elderly: a multi-centre, placebo-controlled study with pantoprazole
    A Pilotto
    Geriatric Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Aliment Pharmacol Ther 17:1399-406. 2003
  9. ncbi request reprint Upper gastrointestinal symptoms and therapies in elderly out-patients, users of non-selective NSAIDs or coxibs
    A Pilotto
    Unita Operativa di Geriatria, Casa Sollievo della Sofferenza, IRCCS, San Giovanni Rotondo FG, Italy
    Aliment Pharmacol Ther 22:147-55. 2005
  10. ncbi request reprint NSAID and aspirin use by the elderly in general practice: effect on gastrointestinal symptoms and therapies
    Alberto Pilotto
    Geriatric Unit, Istituto di Ricovero e Cura a Carattere Scientifico, Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Drugs Aging 20:701-10. 2003

Collaborators

Detail Information

Publications97

  1. ncbi request reprint The risk of upper gastrointestinal bleeding in elderly users of aspirin and other non-steroidal anti-inflammatory drugs: the role of gastroprotective drugs
    Alberto Pilotto
    Division of Geriatrics, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo Foggia, Italy
    Aging Clin Exp Res 15:494-9. 2003
    ..The aim of our study was to evaluate the risk of bleeding associated with acute and chronic NSAID or aspirin therapy in elderly subjects, and the influence of gastroprotective treatment on such a risk...
  2. ncbi request reprint Review article: an approach to Helicobacter pylori infection in the elderly
    A Pilotto
    Department of Geriatrics, Digestive Pathophysiology Centre for the Elderly, San Bortolo Hospital, Vicenza, Italy
    Aliment Pharmacol Ther 16:683-91. 2002
    ..Low compliance and antibiotic resistance are the main factors related to treatment failure in old age...
  3. ncbi request reprint Drug use by the elderly in general practice: effects on upper gastrointestinal symptoms
    Alberto Pilotto
    Geriatric Unit, Casa Sollievo della Sofferenza, IRCCS, 71013, San Giovanni Rotondo, Italy
    Eur J Clin Pharmacol 62:65-73. 2006
    ..To evaluate the prevalence of drug use by elderly outpatients in Italy and to identify the association between drug use and gastrointestinal symptoms...
  4. ncbi request reprint Long-term clinical outcome of elderly patients with reflux esophagitis: a six-month to three-year follow-up study
    Alberto Pilotto
    Digestive Pathophysiology Center for the Elderly, Dept of Geriatrics, Vicenza, Italy
    Am J Ther 9:295-300. 2002
    ..The presence of typical symptoms, hiatal hernia, and a severe grade of esophagitis are risk factors for relapse. The most effective measure for minimizing the occurrence of relapse is a maintenance therapy with antisecretory drugs...
  5. ncbi request reprint Influence of Helicobacter pylori infection on severity of oesophagitis and response to therapy in the elderly
    A Pilotto
    Digestive Pathophysiology Centre, Geriatric Division, San Bortolo Hospital, Vicenza, Italy
    Dig Liver Dis 34:328-31. 2002
    ..However the relationship between Helicobacter pylori infection and the clinical behaviour of oesophagitis has not yet been clarified...
  6. ncbi request reprint Helicobacter pylori infection in geriatrics
    Alberto Pilotto
    Fisiopatologia Digestiva dell Anziano, UO Geriatria, Ospedale San Bortolo, Vicenza, Italy
    Helicobacter 7:56-62. 2002
    ..Low doses of both PPIs and clarithromycin (in combination with standard doses of amoxycillin or nitroimidazoles) are sufficient. Antibiotic resistance and low compliance are the main factors related to treatment failure at any age...
  7. ncbi request reprint Recent advances in the treatment of GERD in the elderly: focus on proton pump inhibitors
    A Pilotto
    IRCCS, Casa Sollievo della Sofferenza, Istituto di Ricovero e Cura a Carattere Scientifico, San Giovanni Rotondo, Italy
    Int J Clin Pract 59:1204-9. 2005
    ..In addition, the PPIs seem to be safe both in short- and in long-term therapy of elderly patients with GERD...
  8. ncbi request reprint Short- and long-term therapy for reflux oesophagitis in the elderly: a multi-centre, placebo-controlled study with pantoprazole
    A Pilotto
    Geriatric Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Aliment Pharmacol Ther 17:1399-406. 2003
    ..No placebo-controlled clinical trials have yet been published on the efficacy of therapy in older subjects with oesophagitis...
  9. ncbi request reprint Upper gastrointestinal symptoms and therapies in elderly out-patients, users of non-selective NSAIDs or coxibs
    A Pilotto
    Unita Operativa di Geriatria, Casa Sollievo della Sofferenza, IRCCS, San Giovanni Rotondo FG, Italy
    Aliment Pharmacol Ther 22:147-55. 2005
    ..The association between coxib or non-steroidal anti-inflammatory drug use with gastrointestinal symptoms and drug prescriptions in ambulatory elderly patients is not well defined...
  10. ncbi request reprint NSAID and aspirin use by the elderly in general practice: effect on gastrointestinal symptoms and therapies
    Alberto Pilotto
    Geriatric Unit, Istituto di Ricovero e Cura a Carattere Scientifico, Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Drugs Aging 20:701-10. 2003
    ..The relationship between NSAID use and gastrointestinal (GI) symptoms and their treatment in elderly patients is not well defined...
  11. ncbi request reprint Aging and upper gastrointestinal disorders
    Alberto Pilotto
    Geriatric Unit, Istituto di Ricovero e Cura a Carattere Scientifico, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo Foggia 71013, Italy
    Best Pract Res Clin Gastroenterol 18:73-81. 2004
    ..Strategies for subgroups of patients that will take account of the GI and non-GI risks, i.e. disability, co-morbidity and friality of patients, according to a comprehensive geriatric assessment are recommended...
  12. ncbi request reprint Proton-pump inhibitors reduce the risk of uncomplicated peptic ulcer in elderly either acute or chronic users of aspirin/non-steroidal anti-inflammatory drugs
    A Pilotto
    Unita Operativa di Geriatria, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy
    Aliment Pharmacol Ther 20:1091-7. 2004
    ....
  13. ncbi request reprint Effect of Helicobacter pylori eradication on the outcome of reflux esophagitis and chronic gastritis in the elderly. A randomized, multicenter, eight-month study
    Alberto Pilotto
    Geriatric Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Gerontology 52:99-106. 2006
    ..The effect of Helicobacter pylori eradication on the clinical outcome of esophagitis in elderly patients is controversial...
  14. ncbi request reprint Clinical features of reflux esophagitis in older people: a study of 840 consecutive patients
    Alberto Pilotto
    Geriatric Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    J Am Geriatr Soc 54:1537-42. 2006
    ..To compare symptoms and other clinical characteristics of reflux esophagitis in patients of different ages...
  15. pmc Usefulness of the comprehensive geriatric assessment in older patients with upper gastrointestinal bleeding: a two-year follow-up study
    Alberto Pilotto
    Geriatric Unit and Gerontology and Geriatrics Research Laboratories, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Dig Dis 25:124-8. 2007
    ..Aim: To evaluate the usefulness of the CGA as a 2-year mortality multidimensional prognostic index (MPI) in older patients hospitalized for upper gastrointestinal bleeding...
  16. ncbi request reprint Noninvasive diagnosis of Helicobacter pylori infection in older subjects: comparison of the 13C-urea breath test with serology
    A Pilotto
    Department of Geriatrics, S Bortolo Hospital, Vicenza, Italy
    J Gerontol A Biol Sci Med Sci 55:M163-7. 2000
    ..e., the 13C-urea breath test (13C-UBT) and serology (immunoglobulin G [IgG] anti-Hp antibodies), in older subjects is not known...
  17. ncbi request reprint Pantoprazole versus one-week Helicobacter pylori eradication therapy for the prevention of acute NSAID-related gastroduodenal damage in elderly subjects
    A Pilotto
    Digestive Pathophysiology Center, Department of Geriatrics, Vicenza, Italy
    Aliment Pharmacol Ther 14:1077-82. 2000
    ..To compare the efficacy of pantoprazole vs. a one-week Helicobacter pylori eradication therapy for the prevention of NSAID-related gastroduodenal damage...
  18. ncbi request reprint Incidence of secondary Helicobacter pylori resistance to antibiotics in treatment failures after 1-week proton pump inhibitor-based triple therapies: a prospective study
    A Pilotto
    Department of Geriatrics, S Bortolo Hospital, Vicenza, Italy
    Dig Liver Dis 32:667-72. 2000
    ..Antibiotic-resistant Helicobacter pylori strains are becoming increasingly prevalent, although it is not clear to what extent the new resistant organisms will spread...
  19. ncbi request reprint Prevalence of Helicobacter pylori resistance to antibiotics in Northeast Italy: a multicentre study. GISU. Interdisciplinary Group for the Study of Ulcer
    A Pilotto
    Geriatric Department, San Bortolo Hospital, Vicenza, Italy
    Dig Liver Dis 32:763-8. 2000
    ..To evaluate prevalence of primary Helicobacter pylori antibiotic resistances in Northeast Italy and to identify risk factors associated with this resistance...
  20. ncbi request reprint Cure of Helicobacter pylori infection in elderly patients: comparison of low versus high doses of clarithromycin in combination with amoxicillin and pantoprazole
    A Pilotto
    Department of Geriatrics, Pathophysiology Center for the Elderly, S Bortolo Hospital, Vicenza, Italy
    Aliment Pharmacol Ther 15:1031-6. 2001
    ..Advancing age may influence clarithromycin's pharmacokinetics. No studies have yet compared the effects of different dosages of clarithromycin in combination with a proton pump inhibitor and amoxicillin in elderly patients...
  21. ncbi request reprint Helicobacter pylori-associated peptic ulcer disease in older patients: current management strategies
    A Pilotto
    Digestive Physiopathology Center for the Elderly, Department of Geriatrics, Vicenza, Italy
    Drugs Aging 18:487-94. 2001
    ..or by noninvasive methods. In elderly patients, the 13C-urea breath test demonstrated significantly higher sensitivity, specificity and diagnostic accuracy for detecting H. pylori infection than anti-H. pylori antibodies...
  22. ncbi request reprint Helicobacter pylori infection and the prevention of peptic ulcer with proton pump inhibitors in elderly subjects taking low-dose aspirin
    A Pilotto
    Geriatric Unit, Casa Sollievo della Sofferenza, Istituto di Ricovero e Cura a Carattere Scientifico, San Giovanni Rotondo, Foggia, Italy
    Dig Liver Dis 36:666-70. 2004
    ..The role of Helicobacter pylori infection on the risk of low-dose aspirin-related gastroduodenal damage and on the efficacy of the prevention therapy in elderly chronic users of low-dose aspirin is still controversial...
  23. ncbi request reprint Efficacy of 7 day lansoprazole-based triple therapy for Helicobacter pylori infection in elderly patients
    A Pilotto
    Department of Geriatrics, S Bortolo Hospital, Vicenza, Italy
    J Gastroenterol Hepatol 14:468-75. 1999
    ..The prevalence of Helicobacter pylori increases with age. However, data regarding the effects of anti-H. pylori treatments in the elderly are very scarce...
  24. ncbi request reprint The effect of antibiotic resistance on the outcome of three 1-week triple therapies against Helicobacter pylori
    A Pilotto
    Department of Geriatrics, S Bortolo Hospital, Vicenza, Italy
    Aliment Pharmacol Ther 13:667-73. 1999
    ..Resistance of Helicobacter pylori to antibiotics may be a major reason for treatment failure...
  25. ncbi request reprint Rapid improvement of symptomatology with pantoprazole, amoxycillin and metronidazole in Helicobacter pylori-positive duodenal ulcer patients
    A Pilotto
    Dept of Geriatrics, S Bortolo Hospital, Vicenza, Italy
    Hepatogastroenterology 46:245-51. 1999
    ..To evaluate the efficacy and tolerability of a new 1-week triple therapy regimen consisting of pantoprazole, amoxycillin and metronidazole...
  26. ncbi request reprint Dietary fatty acids, age-related cognitive decline, and mild cognitive impairment
    V Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit University of Bari, Bari, Italy
    J Nutr Health Aging 12:382-6. 2008
    ....
  27. ncbi request reprint Randomized study of different 'second-line' therapies for Helicobacter pylori infection after failure of the standard 'Maastricht triple therapy'
    F Perri
    Division of Gastroenterology, Hospital, IRCCS, San Giovanni Rotondo, Italy
    Aliment Pharmacol Ther 18:815-20. 2003
    ....
  28. ncbi request reprint Different models of frailty in predementia and dementia syndromes
    F Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy
    J Nutr Health Aging 15:711-9. 2011
    ....
  29. ncbi request reprint Metabolic syndrome, mild cognitive impairment, and dementia
    F Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Curr Alzheimer Res 8:492-509. 2011
    ..At present, vascular risk factor management could be decisive in delaying the onset of dementia syndromes or in preventing the progression of predementia syndromes...
  30. ncbi request reprint Interacting with γ-secretase for treating Alzheimer's disease: from inhibition to modulation
    F Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy
    Curr Med Chem 18:5430-47. 2011
    ..Further understanding of the reasons of the failures of these γ-secretase-based drugs in AD may be important for the future research on effective treatments for this devastating disease...
  31. ncbi request reprint Lack of association between Helicobacter pylori infection and extracardiac atherosclerosis in dyspeptic elderly subjects
    A Pilotto
    Division of Geriatric Medicine, S Bortolo Hospital, Vicenza, Italy
    Age Ageing 28:367-71. 1999
    ..There are conflicting data on the association between Helicobacter pylori (HP) infection and cardiovascular diseases...
  32. ncbi request reprint Upper gastrointestinal diseases in the elderly: report of a meeting held at Vicenza, Italy, on 20 March 1998
    A Pilotto
    Department of Geriatrics, S Bortolo Hospital, Vicenza, Italy
    Eur J Gastroenterol Hepatol 11:801-8. 1999
    ..The identification of risk factors of NSAID-related gastroduodenal damage must be the foundation of preventive medical care for elderly subjects...
  33. ncbi request reprint Prevention of acute NSAID-related gastroduodenal damage: a meta-analysis of controlled clinical trials
    G Leandro
    Gastroenterological Hospital S. De Bellis, IRCCS, Castellana Grotte (BA, Italy
    Dig Dis Sci 46:1924-36. 2001
    ....
  34. ncbi request reprint Mediterranean diet in predementia and dementia syndromes
    V Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Curr Alzheimer Res 8:520-42. 2011
    ....
  35. ncbi request reprint Influence of cognitive impairment and comorbidity on disability in hospitalized elderly patients
    G Orsitto
    Geriatric Unit, IRCCS, Casa Spllievo della Sofferenza, San Giovanni Rotondo, Italy
    J Nutr Health Aging 9:194-8. 2005
    ..The effects of cognitive impairment and comorbidity on the prevalence of disability in elderly patients who are hospitalized in acute wards are not well defined...
  36. ncbi request reprint Proton-pump inhibitors and outcome of endoscopic hemostasis in bleeding peptic ulcers: a series of meta-analyses
    A Andriulli
    Divisions of Gastroenterology and Geriatrics, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy
    Am J Gastroenterol 100:207-19. 2005
    ..To perform meta-analyses of studies on outcome of bleeding ulcers of different proton-pump inhibitors (PPIs) regimens, after stratification of patients by endoscopic stigmata, and analysis of studies with and without endotherapy...
  37. ncbi request reprint A multidimensional approach to the geriatric patient with chronic kidney disease
    Alberto Pilotto
    IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    J Nephrol 23:S5-10. 2010
    ..All of these findings support the concept that a multidimensional approach may be appropriate for the evaluation of older patients with CKD, as has been reported for patients with other pathological conditions...
  38. doi request reprint Optimal management of peptic ulcer disease in the elderly
    Alberto Pilotto
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Drugs Aging 27:545-58. 2010
    ....
  39. doi request reprint The Comprehensive Geriatric Assessment and the multidimensional approach. A new look at the older patient with gastroenterological disorders
    Alberto Pilotto
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, Italy
    Best Pract Res Clin Gastroenterol 23:829-37. 2009
    ....
  40. ncbi request reprint Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome P450 2C9 polymorphisms
    Alberto Pilotto
    Geriatric Unit, Department of Medical Sciences, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Gastroenterology 133:465-71. 2007
    ..The aim of this study was to evaluate the impact of CYP2C9 polymorphisms on the risk of gastroduodenal bleeding in acute NSAID users...
  41. ncbi request reprint Aging and the gastrointestinal tract
    A Pilotto
    Geriatric Division, S Bortolo Hospital, Vicenza, Italy
    Ital J Gastroenterol Hepatol 31:137-53. 1999
    ....
  42. ncbi request reprint Validation of a Modified-Multidimensional Prognostic Index (m-MPI) including the Mini Nutritional Assessment Short-Form (MNA-SF) for the prediction of one-year mortality in hospitalized elderly patients
    D Sancarlo
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    J Nutr Health Aging 15:169-73. 2011
    ....
  43. doi request reprint Short arm of chromosome 11 and sporadic Alzheimer's disease: catalase and cathepsin D gene polymorphisms
    Cristiano Capurso
    Department of Geriatrics, University of Foggia, Ospedali Riuniti, viale L Pinto, 71100 Foggia, Italy
    Neurosci Lett 432:237-42. 2008
    ..Our data, at present, do not support a role of two gene polymorphisms of the short arm of the chromosome 11, the CAT rs1001179 and CTSD rs17571, as a possible susceptibility factors for sporadic AD...
  44. doi request reprint Interleukin 6-174 G/C promoter and variable number of tandem repeats (VNTR) gene polymorphisms in sporadic Alzheimer's disease
    Cristiano Capurso
    Department of Geriatrics, University of Foggia, Ospedali Riuniti, viale L Pinto, 71100 Foggia, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 34:177-82. 2010
    ..Furthermore, the C allele of the IL-6 variable number of tandem repeats (VNTR) polymorphism was associated with a delayed onset and a decreased risk of AD...
  45. ncbi request reprint Serum pepsinogen and gastrin levels in HIV-positive patients: relationship with CD4+ cell count and Helicobacter pylori infection
    P Fabris
    Department of Infectious Diseases and Tropical Medicine, S Bortolo Hospital, Vicenza, Italy
    Aliment Pharmacol Ther 16:807-11. 2002
    ..The relationship between serum parameters of gastric function and Helicobacter pylori infection in human immunodeficiency virus (HIV)-positive patients is almost unknown...
  46. doi request reprint Fatal systemic venous air embolism during endoscopic retrograde cholangiopancreatography
    Michele Bisceglia
    Department of Pathology, Division of Digestive Endoscopy, IRCCS Casa Sollievo della Sofferenza Hospital, Viale Cappuccini, San Giovanni Rotondo FG, Italy
    Adv Anat Pathol 16:255-62. 2009
    ....
  47. ncbi request reprint Undercoding of Alzheimer's disease and related dementias in hospitalized elderly patients in Italy
    Antonio Greco
    Internal Medicine Department, Casa Sallievo della Sofferenza San Giovanni Rotondo, IRCCS, Italy
    Am J Alzheimers Dis Other Demen 20:167-70. 2005
    ..AD and ADRD are undercoded in elderly hospitalized patients. The limits of the ICD9-CM classification system and the influence of reimbursement amounts may influence the coding reports by physicians...
  48. ncbi request reprint Prevalence, clinical features and avoidability of adverse drug reactions as cause of admission to a geriatric unit: a prospective study of 1756 patients
    Marilisa Franceschi
    Department of Medical Sciences, Geriatric Unit and Gerontology Geriatrics Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Drug Saf 31:545-56. 2008
    ..Drug use increases with advancing age, and in older patients it is associated with an increase in adverse drug reactions (ADRs). ADRs are a primary cause of morbidity and mortality worldwide...
  49. doi request reprint Association analysis of GRIN2B, encoding N-methyl-D-aspartate receptor 2B subunit, and Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, San Giovanni Rotondo, Italy
    Dement Geriatr Cogn Disord 25:287-92. 2008
    ..Glutamate transmits signals via the N-methyl-D-aspartate receptors (NMDARs). Aims: The potential involvement of polymorphisms in the GRIN2B gene, encoding subunit 2B of the NMDA receptor, in the risk for AD was evaluated...
  50. ncbi request reprint Deep venous thrombosis in elderly hospitalized patients: prevalence and clinical features
    Maria Grazia Longo
    Geriatric Unit, Casa Sollievo della Sofferenza, IRCCS, San Giovanni Rotondo FG, Italy
    Aging Clin Exp Res 17:42-5. 2005
    ..This study aimed at evaluating the effect of age on the prevalence and clinical features of DVT in patients admitted to acute medical wards in a general hospital...
  51. pmc The complex interaction between APOE promoter and AD: an Italian case-control study
    Alessandra Bizzarro
    Institute of Neurology, Department of Neuroscience, Catholic University School of Medicine, Rome, Italy
    Eur J Hum Genet 17:938-45. 2009
    ..Therefore this study confirms the role of the rs449647 A/A genotype as risk factor for AD in Italy and suggests that promoter genotypes and APOE haplotypes might have a complex function in AD-associated genetic risk factors...
  52. pmc Association of apolipoprotein E and angiotensin converting enzyme gene polymorphisms with the multidimensional impairment in older patients
    Alberto Pilotto
    Department of Medical Sciences, Geriatric Unit and Gerontology Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Rejuvenation Res 12:239-47. 2009
    ..No significant associations between APOE and ACE polymorphisms and 2-year mortality were found. APOE and ACE genes might predispose individuals to health and functional status deterioration in old age, and their effect is additive...
  53. ncbi request reprint Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy
    Davide Seripa
    Laboratory of Geriatrics and Gerontology, Research Department, IRCCS Casa Sollievo della Sofferenza, Viale San Giovanni Rotondo, Italy
    J Gerontol A Biol Sci Med Sci 61:918-23. 2006
    ..636). Heterosis was also observed at the ACE locus. No relationship between apoE and ACE polymorphism was found. These findings suggest a role of sex in the association of apoE and ACE gene polymorphisms with healthy aging and longevity...
  54. ncbi request reprint Detection of Chlamydophila pneumoniae DNA in peripheral blood mononuclear cells of blood donors in the north-east of Italy
    M Rassu
    Department of Microbiology, S Bortolo Hospital, Vicenza, Italy
    Med Microbiol Immunol 190:139-44. 2001
    ..7%). Seroepidemiological studies showed a high percentage of positivity both in subjects positive by PCR (65.91%) and negative by PCR (71.74%). The clinical implication of such finding are under study...
  55. ncbi request reprint Vascular risk factors, alcohol intake, and cognitive decline
    F Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Bari, Italy
    J Nutr Health Aging 12:376-81. 2008
    ..At present, vascular risk factor management, lifestyle changes, and drugs could be employed together to delay the onset of dementia syndromes...
  56. doi request reprint Late-life depression, mild cognitive impairment, and dementia: possible continuum?
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Am J Geriatr Psychiatry 18:98-116. 2010
    ..In this scenario, at least in certain subsets of elderly patients, late-life depression, MCI, and dementia could represent a possible clinical continuum...
  57. doi request reprint Alpha-2-macroglobulin gene, oxidized low-density lipoprotein receptor-1 locus, and sporadic Alzheimer's disease
    Anna Maria Colacicco
    Department of Geriatrics, Center for Aging Brain, University of Bari, Italy
    Neurobiol Aging 30:1518-20. 2009
    ....
  58. ncbi request reprint The RELN locus in Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatric Research Laboratory, Department of Medical Sciences, I R C C S Casa Sollievo dalla Sofferenza, San Giovanni Rotondo FG, I 71013, Italy
    J Alzheimers Dis 14:335-44. 2008
    ..These findings suggest that RELN gene variants may play a role in the pathogenesis of AD, particularly in females...
  59. ncbi request reprint Aberrant DNA methylation in non-neoplastic gastric mucosa of H. Pylori infected patients and effect of eradication
    Francesco Perri
    Department of Gastroenterology, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy
    Am J Gastroenterol 102:1361-71. 2007
    ..Gene promoter methylation is an epigenetic event leading to gene silencing. This mechanism is particularly relevant in cancer since it can interfere with the activity of specific "suppressor" genes...
  60. pmc The Multidimensional Prognostic Index (MPI), based on a comprehensive geriatric assessment predicts short- and long-term mortality in hospitalized older patients with dementia
    Alberto Pilotto
    Department of Medical Sciences, Geriatric Unit and Gerontology Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    J Alzheimers Dis 18:191-9. 2009
    ..In conclusion, the MPI, calculated from information collected in a standardized CGA, accurately stratified hospitalized elderly patients with dementia into groups at varying risk of short- and long-term mortality...
  61. doi request reprint The prevalence of diarrhea and its association with drug use in elderly outpatients: a multicenter study
    Alberto Pilotto
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo FG, Italy
    Am J Gastroenterol 103:2816-23. 2008
    ..To evaluate the prevalence of diarrhea and its association with drug use in elderly outpatients...
  62. doi request reprint Polymorphism C in the serotonin transporter gene (SLC6A4) in questionable dementia and Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo FG, Italy
    Neurosci Lett 438:335-9. 2008
    ..No further differences among the three groups of subjects were found, also when they were compared with the community-dwelling sample. These findings suggest that SLC6A4 gene variation may have only a minor role, if any, in AD or QD...
  63. ncbi request reprint Non-apolipoprotein E and apolipoprotein E genetics of sporadic Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo FG, Italy
    Ageing Res Rev 8:214-36. 2009
    ..The second part of this article focused on some recently discovered aspects of the APOE polymorphism and their implications for SAD. An attempt to identify the future directions for non-APOE genetic research in SAD was also discussed...
  64. doi request reprint Pharmacogenetics of cytochrome P450 (CYP) in the elderly
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo FG, Italy
    Ageing Res Rev 9:457-74. 2010
    ..The status of what we know and what we need to know is the base for the clinical applications of pharmacogenetics, in which personalized drug treatments constituted the main aim, in particular in patients attending a geriatric ward...
  65. pmc Multidimensional Prognostic Index based on a comprehensive geriatric assessment predicts short-term mortality in older patients with heart failure
    Alberto Pilotto
    Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Circ Heart Fail 3:14-20. 2010
    ..The aim of this study was to evaluate whether a Multidimensional Prognostic Index (MPI) based on a comprehensive geriatric assessment predicts short-term mortality in older patients with heart failure...
  66. pmc Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease
    Alberto Pilotto
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo FG, Italy
    Neurology 73:761-7. 2009
    ..To evaluate the influence of the single nucleotide polymorphism rs1080985 in the cytochrome P450 2D6 (CYP2D6) gene on the efficacy of donepezil in patients with mild to moderate Alzheimer disease (AD)...
  67. ncbi request reprint Current epidemiology of mild cognitive impairment and other predementia syndromes
    Francesco Panza
    Dept of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Am J Geriatr Psychiatry 13:633-44. 2005
    ..To clarify the sources of discrepant findings in the literature, this review summarizes existing epidemiological studies of the defined clinical predementia syndromes and their progression to dementia...
  68. pmc Development and validation of a multidimensional prognostic index for one-year mortality from comprehensive geriatric assessment in hospitalized older patients
    Alberto Pilotto
    Department of Medical Sciences and Gerontology and Geriatrics Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Rejuvenation Res 11:151-61. 2008
    ..751 (95%CI, 0.71-0.80) at 1 year of follow-up. We conclude that this MPI, calculated from information collected in a standardized CGA, accurately stratifies hospitalized elderly patients into groups at varying risk of mortality...
  69. ncbi request reprint Apolipoprotein E genotypes in hospitalized elderly patients with vascular dementia
    Giuseppe Orsitto
    Geriatric Unit, Medical Sciences Department, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Dement Geriatr Cogn Disord 23:327-33. 2007
    ..However, it is still unclear if a relationship exists between the APOE epsilon4 allele and vascular dementia (VaD) in elderly subjects...
  70. doi request reprint Polymorphism C in the serotonin transporter gene in depression-free elderly patients with vascular dementia
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy dseripa operapadrepio it
    Dement Geriatr Cogn Disord 29:424-31. 2010
    ..Less clear are data regarding their association with severe dementia, in particular with vascular dementia (VaD)...
  71. ncbi request reprint Comparison of a monoclonal antigen stool test (Hp StAR) with the 13C-urea breath test in monitoring Helicobacter pylori eradication therapy
    Francesco Perri
    Department of Internal Medicine, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy
    World J Gastroenterol 11:5878-81. 2005
    ..To evaluate the agreement between a mAb-based stool test (HP StAR) and the urea breath test (UBT) in monitoring (H pylori) infection after eradication therapy...
  72. doi request reprint Metabolic-cognitive syndrome: a cross-talk between metabolic syndrome and Alzheimer's disease
    Vincenza Frisardi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11, 70124, Bari, Italy
    Ageing Res Rev 9:399-417. 2010
    ....
  73. ncbi request reprint Artificial neural networks can classify uninvestigated patients with dyspepsia
    Angelo Andriulli
    Division of Gastroenterology, Casa Sollievo Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy
    Eur J Gastroenterol Hepatol 19:1055-8. 2007
    ..With this ability, ANNs can be used to assist in the classification and treatment of patients with uninvestigated dyspepsia, and to bring a greater level of confidence to this process...
  74. ncbi request reprint Cognitive frailty: Predementia syndrome and vascular risk factors
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Neurobiol Aging 27:933-40. 2006
    ..This review will focus on the possible role of vascular risk factors in modulating the risk of age-related cognitive decline, and the progression of predementia syndrome such as MCI to dementia...
  75. doi request reprint Development and validation of a new questionnaire for the evaluation of upper gastrointestinal symptoms in the elderly population: a multicenter study
    Alberto Pilotto
    Department of Medical Sciences, Geriatric Unit and Gerontology Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 10, San Giovanni Rotondo, Foggia, Italy
    J Gerontol A Biol Sci Med Sci 65:174-8. 2010
    ..Objectives To develop and validate a diagnostic tool for evaluating upper gastrointestinal symptoms in older patients...
  76. ncbi request reprint Comparison of four proton pump inhibitors for the short-term treatment of esophagitis in elderly patients
    Alberto Pilotto
    Geriatric Unit, IRCCS, Casa Sollievo della Sofferenza, Viale Cappuccini, 71013, San Giovanni Rotondo FG, Italy
    World J Gastroenterol 13:4467-72. 2007
    ..To compare efficacy and tolerability of four proton pump inhibitors (PPIs) commonly used in the short-term therapy of esophagitis in elderly patients...
  77. pmc The multidimensional prognostic index predicts short- and long-term mortality in hospitalized geriatric patients with pneumonia
    Alberto Pilotto
    Department of Medical Sciences, Geriatric Unit and Gerontology Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, Foggia I 71013, Italy
    J Gerontol A Biol Sci Med Sci 64:880-7. 2009
    ..Our purpose is to evaluate the usefulness of a multidimensional prognostic index (MPI) based on a comprehensive geriatric assessment (CGA) for predicting mortality risk in older patients with community-acquired pneumonia (CAP)...
  78. ncbi request reprint Lipoproteins, vascular-related genetic factors, and human longevity
    Francesco Panza
    Department of Geriatrics, Center for Lipoprotein Metabolism and Atherosclerosis, University of Bari, Policlinico, Piazza Giulio Cesare 11, Bari, Italy
    Rejuvenation Res 10:441-58. 2007
    ..While further studies are needed to confirm the possible role of apolipoprotein E concentration as putative longevity factor this paper provides an overview of many of the investigated vascular factors with respect to longevity...
  79. ncbi request reprint Beyond the neurotransmitter-focused approach in treating Alzheimer's disease: drugs targeting beta-amyloid and tau protein
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, 70124, Bari, Italy
    Aging Clin Exp Res 21:386-406. 2009
    ..With all these approaches on their way, the hope for disease-modifying therapy in this devastating disease may become a reality in the next 5 years...
  80. ncbi request reprint Incidence rates of post-ERCP complications: a systematic survey of prospective studies
    Angelo Andriulli
    Gastroenterology Unit, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy
    Am J Gastroenterol 102:1781-8. 2007
    ..To provide health-care providers, patients, and physicians with an exhaustive assessment of prospective studies on rates of complications and fatalities associated with endoscopic retrograde cholangiopancreatography (ERCP)...
  81. doi request reprint Alcohol drinking, cognitive functions in older age, predementia, and dementia syndromes
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    J Alzheimers Dis 17:7-31. 2009
    ..At present, there is no indication that light to moderate alcohol drinking would be harmful to cognition and dementia, and it is not possible to define a specific beneficial level of alcohol intake...
  82. doi request reprint Aluminum in the diet and Alzheimer's disease: from current epidemiology to possible disease-modifying treatment
    Vincenza Frisardi
    Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy
    J Alzheimers Dis 20:17-30. 2010
    ....
  83. ncbi request reprint All patient refined diagnosis related groups: a new administrative tool for identifying elderly patients at risk of high resource consumption
    Alberto Pilotto
    J Am Geriatr Soc 53:167-8. 2005
  84. ncbi request reprint Early epigastric pain after PPI administration: exacerbation of Helicobacter pylori corpus gastritis?
    Francesco Di Mario
    Helicobacter 9:92-4. 2004
  85. ncbi request reprint Rabeprazole in a one-week eradication therapy of Helicobacter pylori: comparison of different dosages
    Francesco Di Mario
    Department of Clinical Science, University of Parma, Parma, Italy
    J Gastroenterol Hepatol 18:783-6. 2003
    ..We report the efficacy and tolerability of rabeprazole in different dosages in association with clarithromycin (C)and tinidazole (T) in H. pylori eradication...
  86. ncbi request reprint Clinical usefulness of serum pepsinogen II in the management of Helicobacter pylori infection
    Francesco Di Mario
    Department of Clinical Sciences, Chair of Gastroenterology, University of Parma, Parma, Italy
    Digestion 70:167-72. 2004
    ..Serum pepsinogen II (sPGII) levels are known to increase during Helicobacter pylori infection...
  87. ncbi request reprint Use of lactoferrin for Helicobacter pylori eradication. Preliminary results
    Francesco Di Mario
    Section of Gastroenterology, University of Parma, Italy
    J Clin Gastroenterol 36:396-8. 2003
    ..Our aim was to test the efficacy of a standard triple therapy plus bovine lactoferrin for the eradication of H. pylori infection...
  88. ncbi request reprint A curcumin-based 1-week triple therapy for eradication of Helicobacter pylori infection: something to learn from failure?
    Francesco Di Mario
    Section of Gastroenterology, Department of Clinical Sciences, University of Parma, Italy
    Helicobacter 12:238-43. 2007
    ..N-acetylcysteine and lactoferrin with their respective mucolytic and antibacterial activities might also be effective in H. pylori eradication therapy...
  89. ncbi request reprint Diverticular disease in the elderly
    Giuseppe Comparato
    University of Parma, Parma, Italy
    Dig Dis 25:151-9. 2007
    ..Postoperative mortality and morbidity are to a large extent driven by patient-related factors...
  90. ncbi request reprint Recovery of gastric function after Helicobacter pylori eradication in subjects with body atrophic gastritis: prospective 4-year study
    Francesco Di Mario
    Department of Clinical Sciences, University of Parma, Parma, Italy
    J Gastroenterol Hepatol 20:1661-6. 2005
    ..Although studies report a partial restoration of serum pepsinogen I (sPGI) levels after eradication, it is not clear if this finding reflects gastric mucosal healing on a morphological level...
  91. ncbi request reprint Helicobacter pylori infection and the risk of gastro-duodenal damage in symptomatic elderly chronic low-dose aspirin users: effect of antisecretory drugs
    Alberto Pilotto
    Age Ageing 33:402-4. 2004
  92. ncbi request reprint Effects of chronic therapy with non-steroidal antiinflammatory drugs on gastric permeability of sucrose: a study on 71 patients with rheumatoid arthritis
    Marta Maino
    Department of Clinical Science, University of Parma, Via Gramsci 14, Parma 43100, Italy
    World J Gastroenterol 12:5017-20. 2006
    ....
  93. ncbi request reprint Apolipoprotein E genotypes in mild cognitive impairment subtypes
    Giuseppe Orsitto
    J Am Geriatr Soc 54:1965-6. 2006
  94. ncbi request reprint Natural course of functional dyspepsia after Helicobacter pylori eradication: a seven-year survey
    Francesco Di Mario
    University of Parma, Parma, Italy
    Dig Dis Sci 50:2286-95. 2005
    ..FD symptoms slightly improve after Hp eradication over a long period of time but a large percentage of these improved patients may experience FD symptoms again, even after some years of well-being after Hp eradication...
  95. ncbi request reprint Quality of life in uncomplicated symptomatic diverticular disease: is it another good reason for treatment?
    Giuseppe Comparato
    University of Parma, Parma, Italy
    Dig Dis 25:252-9. 2007
    ..Quality of life (QoL) is becoming a major issue in the evaluation of any therapeutic intervention...
  96. ncbi request reprint Pancreatic duct stents in the prophylaxis of pancreatic damage after endoscopic retrograde cholangiopancreatography: a systematic analysis of benefits and associated risks
    Angelo Andriulli
    Division of Gastroenterology, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy
    Digestion 75:156-63. 2007
    ....
  97. ncbi request reprint Differences in allele frequencies of ACE I/D polymorphism between Northern and Southern Europe at different ages
    Francesco Panza
    Atherosclerosis 193:455-7. 2007