Salvatore Petta

Summary

Country: Italy

Publications

  1. doi request reprint Industrial, not fruit fructose intake is associated with the severity of liver fibrosis in genotype 1 chronic hepatitis C patients
    Salvatore Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy Electronic address
    J Hepatol 59:1169-76. 2013
  2. doi request reprint High sCD36 plasma level is associated with steatosis and its severity in patients with genotype 1 chronic hepatitis C
    S Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Palermo, Italy
    J Viral Hepat 20:174-82. 2013
  3. doi request reprint Hyperuricemia is associated with histological liver damage in patients with non-alcoholic fatty liver disease
    S Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy
    Aliment Pharmacol Ther 34:757-66. 2011
  4. doi request reprint Visceral adiposity index is associated with significant fibrosis in patients with non-alcoholic fatty liver disease
    S Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy
    Aliment Pharmacol Ther 35:238-47. 2012
  5. doi request reprint Carotid atherosclerosis and chronic hepatitis C: a prospective study of risk associations
    Salvatore Petta
    Sezione di Gastroenterologia, Di Bi M I S, Universita di Palermo, Italia
    Hepatology 55:1317-23. 2012
  6. doi request reprint IL28B and PNPLA3 polymorphisms affect histological liver damage in patients with non-alcoholic fatty liver disease
    Salvatore Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy
    J Hepatol 56:1356-62. 2012
  7. doi request reprint Association of vitamin D serum levels and its common genetic determinants, with severity of liver fibrosis in genotype 1 chronic hepatitis C patients
    S Petta
    Cattedra di Gastroenterologia, DiBiMIS, University of Palermo, Palermo, Italy
    J Viral Hepat 20:486-93. 2013
  8. doi request reprint Vitamin D levels and IL28B polymorphisms are related to rapid virological response to standard of care in genotype 1 chronic hepatitis C
    Salvatore Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Palermo, Italy
    Antivir Ther 17:823-31. 2012
  9. doi request reprint Methylenetetrahydrofolate reductase homozygosis and low-density lipoproteins in patients with genotype 1 chronic hepatitis C
    S Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Palermo, Italy
    J Viral Hepat 19:465-72. 2012
  10. doi request reprint Hyperuricaemia: another metabolic feature affecting the severity of chronic hepatitis because of HCV infection
    Salvatore Petta
    Cattedra di Gastroenterologia, DiBiMIS, University of Palermo, Palermo, Italy
    Liver Int 32:1443-50. 2012

Collaborators

Detail Information

Publications39

  1. doi request reprint Industrial, not fruit fructose intake is associated with the severity of liver fibrosis in genotype 1 chronic hepatitis C patients
    Salvatore Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy Electronic address
    J Hepatol 59:1169-76. 2013
    ..In a cohort of patients with genotype 1 chronic hepatitis C (G1 CHC), we tested the association of fructose intake with the severity of liver histology...
  2. doi request reprint High sCD36 plasma level is associated with steatosis and its severity in patients with genotype 1 chronic hepatitis C
    S Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Palermo, Italy
    J Viral Hepat 20:174-82. 2013
    ..CD36 is linked to steatosis and insulin resistance in patients with G1 CHC, but does not predict response to treatment. The potential of sCD36 as a surrogate marker of steatosis should be further investigated...
  3. doi request reprint Hyperuricemia is associated with histological liver damage in patients with non-alcoholic fatty liver disease
    S Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy
    Aliment Pharmacol Ther 34:757-66. 2011
    ..Hyperuricemia has been associated with metabolic disorders. In this line recent studies observed an independent link between higher uric acid serum levels and clinical diagnosis of non-alcoholic fatty liver disease (NAFLD)...
  4. doi request reprint Visceral adiposity index is associated with significant fibrosis in patients with non-alcoholic fatty liver disease
    S Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy
    Aliment Pharmacol Ther 35:238-47. 2012
    ..Metabolic factors have been associated with liver damage in patients with non-alcoholic fatty liver disease (NAFLD)...
  5. doi request reprint Carotid atherosclerosis and chronic hepatitis C: a prospective study of risk associations
    Salvatore Petta
    Sezione di Gastroenterologia, Di Bi M I S, Universita di Palermo, Italia
    Hepatology 55:1317-23. 2012
    ..3%) with F3-F4 fibrosis (P = 0.008). By contrast, in patients >55 years the prevalence of carotid plaques was similar in those with or without severe fibrosis (25/43, 58.1% versus 22/43, 51.1%; P = 0.51)...
  6. doi request reprint IL28B and PNPLA3 polymorphisms affect histological liver damage in patients with non-alcoholic fatty liver disease
    Salvatore Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy
    J Hepatol 56:1356-62. 2012
    ..The main outcomes of the study were to assess whether IL28B rs12979860 and rs8099917 polymorphisms, together with PNPLA3 rs738409 C>G polymorphism, are associated with lobular inflammation and fibrosis, in NAFLD patients...
  7. doi request reprint Association of vitamin D serum levels and its common genetic determinants, with severity of liver fibrosis in genotype 1 chronic hepatitis C patients
    S Petta
    Cattedra di Gastroenterologia, DiBiMIS, University of Palermo, Palermo, Italy
    J Viral Hepat 20:486-93. 2013
    ..001). No associations were found between liver fibrosis and both CYP2R1 and GC genotypes. In patients with G1CHC, GG homozygosis for DHCR7 gene and lower 25(OH)D levels are independently associated with the severity of liver fibrosis...
  8. doi request reprint Vitamin D levels and IL28B polymorphisms are related to rapid virological response to standard of care in genotype 1 chronic hepatitis C
    Salvatore Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Palermo, Italy
    Antivir Ther 17:823-31. 2012
    ..We assessed whether 25-hydroxyvitamin D (25[OH]D) serum levels are linked to RVR and can be used together with IL28B to construct a pretreatment model to predict RVR...
  9. doi request reprint Methylenetetrahydrofolate reductase homozygosis and low-density lipoproteins in patients with genotype 1 chronic hepatitis C
    S Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Palermo, Italy
    J Viral Hepat 19:465-72. 2012
    ..In patients with genotype 1 hepatitis C, showing higher homocysteine serum levels than controls, MTHFR C677T homozygosis, via modulating cholesterol levels, could interfere with liver fibrosis and response to antiviral therapy...
  10. doi request reprint Hyperuricaemia: another metabolic feature affecting the severity of chronic hepatitis because of HCV infection
    Salvatore Petta
    Cattedra di Gastroenterologia, DiBiMIS, University of Palermo, Palermo, Italy
    Liver Int 32:1443-50. 2012
    ..Several works observed a link between uric acid serum levels and clinical and histological features of nonalcoholic fatty liver disease. An association between chronic hepatitis C (CHC) and uric acid levels has been poorly investigated...
  11. doi request reprint Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C
    Salvatore Petta
    Division of Gastroenterology, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy
    Clin Gastroenterol Hepatol 11:311-7.e1. 2013
    ..We tested the association between the IL28B rs12979860 single-nucleotide polymorphism and metabolic features, including IR, and evaluated their effects on SVR...
  12. pmc Serum γ-glutamyl transferase levels, insulin resistance and liver fibrosis in patients with chronic liver diseases
    Salvatore Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Palermo, Italy
    PLoS ONE 7:e51165. 2012
    ....
  13. doi request reprint How to optimize HCV therapy in genotype 1 patients: predictors of response
    Salvatore Petta
    Sezione di Gastroenterologia, Di Bi M I S, University of Palermo, Palermo, Italy
    Liver Int 33:23-9. 2013
    ....
  14. doi request reprint Pregnancy outcomes associated with viral hepatitis
    K L B Reddick
    Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA
    J Viral Hepat 18:e394-8. 2011
    ..Women with hepatitis have an increased risk for complications during pregnancy. Research to determine the efficacy and cost-effectiveness of counselling patients about potential risks for adverse outcomes is warranted...
  15. doi request reprint TyG index, HOMA score and viral load in patients with chronic hepatitis C due to genotype 1
    S Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Palermo, Italy
    J Viral Hepat 18:e372-80. 2011
    ..In patients with G1CHC , TyG, an easy-to-calculate and low-cost surrogate marker of IR, is linked to liver steatosis and shows an independent association with viral load...
  16. doi request reprint Reliability of liver stiffness measurement in non-alcoholic fatty liver disease: the effects of body mass index
    S Petta
    Sezione di Gastroenterologia, Di Bi M I S, University of Palermo, Italy
    Aliment Pharmacol Ther 33:1350-60. 2011
    ....
  17. doi request reprint Non-alcoholic fatty liver disease pathogenesis: the present and the future
    S Petta
    Cattedra and Unità Operativa di Gastroenterologia, Di Bi M I S, University of Palermo, Palermo, Italy
    Dig Liver Dis 41:615-25. 2009
    ..In this review we aim to examine the literature, principally concerning human non-alcoholic fatty liver disease pathogenesis, and to identify the newest, most promising clinical and basic research data...
  18. doi request reprint Insulin resistance is a major determinant of liver stiffness in nondiabetic patients with HCV genotype 1 chronic hepatitis
    S Petta
    Cattedra ed Unità Operativa di Gastroenterologia, DiBiMIS, University of Palermo, Palermo, Italy
    Aliment Pharmacol Ther 30:603-13. 2009
    ..Other factors, such as insulin resistance (IR), might influence the performance of LSM...
  19. ncbi request reprint Time course of insulin resistance during antiviral therapy in non-diabetic, non-cirrhotic patients with genotype 1 HCV infection
    Salvatore Petta
    Cattedra ed Unità Operativa di Gastroenterologia, Universita di Palermo, Palermo, Italy
    Antivir Ther 14:631-9. 2009
    ..We aimed to evaluate the time course of IR in response to antiviral therapy in non-diabetic, non-cirrhotic G1 HCV patients and to assess the effect of metabolic factors on sustained virological response (SVR)...
  20. doi request reprint Low vitamin D serum level is related to severe fibrosis and low responsiveness to interferon-based therapy in genotype 1 chronic hepatitis C
    Salvatore Petta
    Cattedra ed Unità Operativa di Gastroenterologia, DiBiMIS, University of Palermo, Italy
    Hepatology 51:1158-67. 2010
    ..Conclusion: G1 CHC patients had low 25(OH)D serum levels, possibly because of reduced CYP27A1 expression. Low vitamin D is linked to severe fibrosis and low SVR on interferon (IFN)-based therapy...
  21. ncbi request reprint Hepatocellular carcinoma and non-alcoholic fatty liver disease: from a clinical to a molecular association
    S Petta
    Cattedra ed Unità Operativa di Gastroenterologia, DiBiMIS, University of Palermo, Italy
    Curr Pharm Des 16:741-52. 2010
    ..A number of studies suggest that these approaches improve IR and reduce steatosis, necroinflammation and fibrosis. A potential role of these therapeutic strategies in the prevention of hepatocarcinogenesis can thus be envisaged...
  22. doi request reprint Visceral adiposity index is associated with histological findings and high viral load in patients with chronic hepatitis C due to genotype 1
    Salvatore Petta
    Dipartimento Biomedico di Medicina Interna e Specialistica, Cattedra di Gastroenterologia, DiBiMIS, Palermo, Italy
    Hepatology 52:1543-52. 2010
    ..04), and fibrosis (OR 2.608, 95% CI 1.565-4.345, P < 0.001) were independently associated with moderate to severe necroinflammatory activity. No independent associations were found between VAI score and both fibrosis and SVR...
  23. doi request reprint Optimal therapy in hepatitis C virus genotypes 2 and 3 patients
    Salvatore Petta
    Sezione di Gastroenterologia ed Epatologia, DiBi MIS, University of Palermo, Palermo, Italy
    Liver Int 31:36-44. 2011
    ..It is possible that the SVR rate in non-RVR patients and non-responder patients could also be improved by prolonging therapy, but this must be specifically investigated in other studies along with the role of IL28B polymorphisms...
  24. doi request reprint High liver RBP4 protein content is associated with histological features in patients with genotype 1 chronic hepatitis C and with nonalcoholic steatohepatitis
    Salvatore Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy
    Dig Liver Dis 43:404-10. 2011
    ..To investigate the hepatic expression of retinol-binding protein-4 (RBP4) in chronic hepatitis C (CHC) and nonalcoholic steatohepatitis (NASH) patients, and its association with biochemical and histological patterns of liver damage...
  25. doi request reprint Hepatic steatosis and insulin resistance are associated with severe fibrosis in patients with chronic hepatitis caused by HBV or HCV infection
    Salvatore Petta
    Sezione di Gastroenterologia, University of Palermo, Palermo, Italy
    Liver Int 31:507-15. 2011
    ..We aimed to assess the prevalence and the factors related to steatosis and IR in CHB patients, compared with CHC subjects, and to evaluate the potential association between these features and fibrosis severity...
  26. pmc Therapeutic algorithms for chronic hepatitis C in the DAA era during the current economic crisis: whom to treat? How to treat? When to treat?
    Salvatore Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy
    BMC Infect Dis 12:S3. 2012
    ....
  27. doi request reprint Insulin resistance and diabetes increase fibrosis in the liver of patients with genotype 1 HCV infection
    Salvatore Petta
    Cattedra ed Unità Operativa di Gastroenterologia, University of Palermo, Palermo, Italy
    Am J Gastroenterol 103:1136-44. 2008
    ..We aimed to assess whether increasing degrees of IR, up to overt diabetes, are linked to steatosis and higher stages of fibrosis in patients with CHC resulting from genotype 1 HCV (G1-HCV)...
  28. doi request reprint Retinol-binding protein 4: a new marker of virus-induced steatosis in patients infected with hepatitis c virus genotype 1
    Salvatore Petta
    Cattedra ed Unità Operativa di Gastroenterologia, University of Palermo, Palermo, Italy
    Hepatology 48:28-37. 2008
    ..045; 95% confidence interval, 1.020 to 1.070; P = 0.0004), whereas waist circumference was associated with moderate-severe steatosis in NAFLD (odds ratio, 1.095; 95% confidence interval, 1.007 to 1.192; P = 0.03)...
  29. doi request reprint Liver follicular helper T-cells predict the achievement of virological response following interferon-based treatment in HCV-infected patients
    Claudio Tripodo
    Cattedra di Anatomia Patologica, University of Palermo, Palermo, Italy
    Antivir Ther 17:111-8. 2012
    ....
  30. doi request reprint Insulin resistance is a risk factor for esophageal varices in hepatitis C virus cirrhosis
    Calogero Cammà
    Cattedra and Unità Operativa di Gastroenterologia, Di Bi M I S, University of Palermo, Italy
    Hepatology 49:195-203. 2009
    ....
  31. doi request reprint Cost-effectiveness of boceprevir or telaprevir for previously treated patients with genotype 1 chronic hepatitis C
    Calogero Cammà
    Sezione di Gastroenterologia, Di Bi M I S, University of Palermo, Italy Electronic address
    J Hepatol 59:658-66. 2013
    ..We assess the cost-effectiveness of TT compared to no therapy in the treatment of patients previously treated with G1 CHC...
  32. doi request reprint Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic Fatty liver disease
    Salvatore Petta
    Sezione di Gastroenterologia, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy
    PLoS ONE 9:e87523. 2014
    ..We aimed to assess whether GCKR rs780094 C→T SNP influences the expression of steatosis, lobular inflammation and fibrosis in NAFLD patients, after correction for PNPLA3 genotype...
  33. pmc PNPLA3 GG genotype and carotid atherosclerosis in patients with non-alcoholic fatty liver disease
    Salvatore Petta
    Di Bi M I S, Sezione di Gastroenterologia, Universita di Palermo, Palermo, Italia
    PLoS ONE 8:e74089. 2013
    ..To evaluate if the presence of carotid atherosclerosis in patients with NAFLD, could be related to gene variants influencing hepatic fat accumulation and the severity of liver damage...
  34. ncbi request reprint Anti-tissue transglutaminase antibodies in patients with abnormal liver tests: is it always coeliac disease?
    Oreste Lo Iacono
    University of Palermo, Gastroenterology and Hepatology Unit, Palermo, Italy
    Am J Gastroenterol 100:2472-7. 2005
    ..In this population the efficacy of screening for CD by anti-tissue transglutaminase (anti-tTG) may be impaired by the high rate of positive anti-tTG found in chronic liver disease...
  35. doi request reprint Cost-effectiveness of sorafenib treatment in field practice for patients with hepatocellular carcinoma
    Calogero Cammà
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy
    Hepatology 57:1046-54. 2013
    ..Results were sensitive to BSC survival rate, and sorafenib treatment duration...
  36. pmc NT pro BNP plasma level and atrial volume are linked to the severity of liver cirrhosis
    Anna Licata
    Sezione di Gastroenterologia, Dipartimento Biomedico di Medicina Interna e Specialistica, Di Bi M I S, University of Palermo, Palermo, Italy
    PLoS ONE 8:e68364. 2013
    ....
  37. ncbi request reprint Non invasive indexes for the assessment of patients with non-alcoholic fatty liver disease
    Salvatore Petta
    Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy
    Curr Pharm Des 19:5193-218. 2013
    ..This review summarizes the present knowledge on noninvasive diagnosis in NAFLD patients, and suggest future directions for this complex research area. ..
  38. doi request reprint Cost-effectiveness of boceprevir or telaprevir for untreated patients with genotype 1 chronic hepatitis C
    Calogero Cammà
    Sezione di Gastroenterologia, Di Bi M I S, University of Palermo, Italy
    Hepatology 56:850-60. 2012
    ..42 with TVR-IL28B. ICER compared with DT was € 8.304 per LYG for BOC-RVR and € 11.455 per LYG for TVR-IL28B. The model was highly sensitive to IL28B CC genotype, likelihood of RVR and sustained virologic response, and BOC/TVR prices...
  39. pmc Metabolic factors and chronic hepatitis C: a complex interplay
    Fabio Salvatore Macaluso
    Section of Gastroenterology, DiBiMIS, University of Palermo, Piazza delle Cliniche 2, 90127 Palermo, Italy
    Biomed Res Int 2013:564645. 2013
    ..In this setting, the importance of a multifaceted evaluation of CHC patients and a prompt correction of modifiable metabolic risk factors should be emphasized...