N Stocchetti

Summary

Affiliation: Ospedale Maggiore
Country: Italy

Publications

  1. ncbi request reprint Hyperventilation in head injury: a review
    Nino Stocchetti
    Neuroscience ICU, Ospedale Maggiore Policlinico, Milan University, IRCCS, Milan
    Chest 127:1812-27. 2005
  2. ncbi request reprint Does the brain become heavier or lighter after trauma? The long story of brain water content and its direct or indirect measurement
    Nino Stocchetti
    Intensive Care Med 31:1009-11. 2005
  3. ncbi request reprint Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial
    Andrew I R Maas
    Department of Neurosurgery, Erasmus MC Rotterdam, Rotterdam, Netherlands
    Lancet Neurol 5:38-45. 2006
  4. ncbi request reprint Sleeping Beauty: a tale still with an uncertain happy ending after head trauma
    Nino Stocchetti
    Crit Care Med 35:1216-7. 2007
  5. pmc Amyloid-beta dynamics correlate with neurological status in the injured human brain
    David L Brody
    Department of Neurology, Washington University, St Louis, MO 63110, USA
    Science 321:1221-4. 2008
  6. pmc European society of intensive care medicine study of therapeutic hypothermia (32-35 °C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial)
    Peter J D Andrews
    Department of Anaesthesia, Critical Care and Pain Management, University of Edinburgh, UK
    Trials 12:8. 2011
  7. pmc Ethics roundtable: 'Open-ended ICU care: can we afford it?'
    David Crippen
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, 644a Saife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 14:222. 2010
  8. pmc Intracranial pressure monitoring in intensive care: clinical advantages of a computerized system over manual recording
    Elisa Roncati Zanier
    Neurosurgical Intensive Care Unit, Department of Anesthesia and Critical Care Medicine, Milan University, Ospedale Maggiore Policlinico, Mangiagalli, e Regina Elena, Fondazione IRCCS, Milano, Italy
    Crit Care 11:R7. 2007
  9. pmc Impact of pyrexia on neurochemistry and cerebral oxygenation after acute brain injury
    N Stocchetti
    Milan University, Neuroscience Intensive Care, Ospedale Policlinico IRCCS, Milan, Italy
    J Neurol Neurosurg Psychiatry 76:1135-9. 2005
  10. ncbi request reprint [How to quantify the severity of brain injury during intensive care after adult head trauma]
    N Stocchetti
    Terapia Intensiva Neuroscienze, Ospedale Maggiore Policlinico IRCCS, Universita di Milano, Milano, Italy
    Minerva Anestesiol 69:232-6. 2003

Detail Information

Publications75

  1. ncbi request reprint Hyperventilation in head injury: a review
    Nino Stocchetti
    Neuroscience ICU, Ospedale Maggiore Policlinico, Milan University, IRCCS, Milan
    Chest 127:1812-27. 2005
    ..This review has specific reference to traumatic brain injury, and is based on an extensive evaluation of the literature and on expert opinion...
  2. ncbi request reprint Does the brain become heavier or lighter after trauma? The long story of brain water content and its direct or indirect measurement
    Nino Stocchetti
    Intensive Care Med 31:1009-11. 2005
  3. ncbi request reprint Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial
    Andrew I R Maas
    Department of Neurosurgery, Erasmus MC Rotterdam, Rotterdam, Netherlands
    Lancet Neurol 5:38-45. 2006
    ..Traumatic brain injury is a major cause of death and disability. We sought to assess the safety and efficacy of dexanabinol, a synthetic cannabinoid analogue devoid of psychotropic activity, in severe traumatic brain injury...
  4. ncbi request reprint Sleeping Beauty: a tale still with an uncertain happy ending after head trauma
    Nino Stocchetti
    Crit Care Med 35:1216-7. 2007
  5. pmc Amyloid-beta dynamics correlate with neurological status in the injured human brain
    David L Brody
    Department of Neurology, Washington University, St Louis, MO 63110, USA
    Science 321:1221-4. 2008
    ..Such dynamics fit well with the hypothesis that neuronal activity regulates extracellular Abeta concentration...
  6. pmc European society of intensive care medicine study of therapeutic hypothermia (32-35 °C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial)
    Peter J D Andrews
    Department of Anaesthesia, Critical Care and Pain Management, University of Edinburgh, UK
    Trials 12:8. 2011
    ..Previous experience with cooling also appears to be important if complications, which may outweigh the benefits of hypothermia, are to be avoided...
  7. pmc Ethics roundtable: 'Open-ended ICU care: can we afford it?'
    David Crippen
    Department of Critical Care Medicine, University of Pittsburgh Medical Center, 644a Saife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Crit Care 14:222. 2010
    ....
  8. pmc Intracranial pressure monitoring in intensive care: clinical advantages of a computerized system over manual recording
    Elisa Roncati Zanier
    Neurosurgical Intensive Care Unit, Department of Anesthesia and Critical Care Medicine, Milan University, Ospedale Maggiore Policlinico, Mangiagalli, e Regina Elena, Fondazione IRCCS, Milano, Italy
    Crit Care 11:R7. 2007
    ..Little is known, however, about how precisely this method reflects the real patterns of ICP after severe TBI. In this study, we compared hourly manual recording with a validated and continuous computerized reference standard...
  9. pmc Impact of pyrexia on neurochemistry and cerebral oxygenation after acute brain injury
    N Stocchetti
    Milan University, Neuroscience Intensive Care, Ospedale Policlinico IRCCS, Milan, Italy
    J Neurol Neurosurg Psychiatry 76:1135-9. 2005
    ..Postischaemic pyrexia exacerbates neuronal damage. Hyperthermia related cerebral changes have still not been well investigated in humans...
  10. ncbi request reprint [How to quantify the severity of brain injury during intensive care after adult head trauma]
    N Stocchetti
    Terapia Intensiva Neuroscienze, Ospedale Maggiore Policlinico IRCCS, Universita di Milano, Milano, Italy
    Minerva Anestesiol 69:232-6. 2003
    ..Early estimation of cerebral damage is complex and prone to mistakes. Accurate, repeated evaluations, based on the combination of clinical observation and imaging, are necessary...
  11. ncbi request reprint Head injury, subarachnoid hemorrhage and intracranial pressure monitoring in Italy
    N Stocchetti
    Istituto Anestesia e Rianimazione Università di Milano, Terapia Intensiva Neuroscienze, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    Acta Neurochir (Wien) 145:761-5; discussion 765. 2003
    ....
  12. ncbi request reprint Inaccurate early assessment of neurological severity in head injury
    Nino Stocchetti
    Neuroscience Intensive Care, Department of Anesthesia and Intensive Care, Ospedale Policlinico IRCCS, Milan University, Via F Sforza 35, 20122 Milan, Italy
    J Neurotrauma 21:1131-40. 2004
    ..Risk factors for this inaccurate evaluation can be identified, and clinical decisions should be based on further examination...
  13. ncbi request reprint Arterio-jugular difference of oxygen content and outcome after head injury
    Nino Stocchetti
    Istituto Anestesia e Rianimazione, Universita di Milano, Terapia Intensiva Neuroscienze, Ospedale Maggiore Policlinico, Milan, Italy
    Anesth Analg 99:230-4. 2004
    ..6 vol%; SD, 1 vol%). This difference was significant (P < 0.001). We conclude that low levels of AJDO2 are correlated with a poor prognosis, whereas normal or high levels of AJDO2 are predictive of better results...
  14. ncbi request reprint Bilateral cannulation of internal jugular veins may worsen intracranial hypertension
    Nino Stocchetti
    Department of Anesthesia and Intensive Care, Milano University, Ospedale Maggiore Policlinico, Istituto di Ricovero e Cura a Carattere Scientifico, Italy
    Anesthesiology 99:1017-8. 2003
  15. ncbi request reprint Time course of intracranial hypertension after traumatic brain injury
    Nino Stocchetti
    Anesthesia and Intensive Care Medicine, Milan University, Neuroscience ICU, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, e Regina Elena, Milan, Italy
    J Neurotrauma 24:1339-46. 2007
    ..In these cases, HICP was significantly worse and required more intense therapies...
  16. ncbi request reprint Refractory intracranial hypertension and "second-tier" therapies in traumatic brain injury
    Nino Stocchetti
    Neuroscience Intensive Care Unit, Ospedale Maggiore Policlinico, Mangiagalli, e Regina Elena, Fondazione IRCCS, Via F Sforza 35, 20122 Milan, Italy
    Intensive Care Med 34:461-7. 2008
    ....
  17. doi request reprint Triggers for aggressive interventions in subarachnoid hemorrhage
    Nino Stocchetti
    Neuroscience ICU, Milan University, Fondazione IRCCS Ca Granda Ospedale Policlinico, Via F Sforza 35, Milan, Italy
    Neurocrit Care 15:324-8. 2011
    ....
  18. ncbi request reprint Traumatic brain injury in pediatric patients
    N Stocchetti
    Neuroscience Intensive Care Unit, IRCCS Foundation Ca Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
    Minerva Anestesiol 76:1052-9. 2010
    ..After the acute phase rehabilitation and families play a fundamental role...
  19. pmc Wet lungs, broken hearts and difficult therapies after subarachnoid hemorrhage
    Nino Stocchetti
    Milan University, Terapia Intensiva Neuroscienze, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via F, Sforza 35, Milano, Italy
    Crit Care 14:140. 2010
    ..The causes of PE need to be identified for appropriate treatment...
  20. ncbi request reprint Hypothermia for brain protection in the non-cardiac arrest patient
    N Stocchetti
    Neuroscience Intensive Care Unit, Department of Anesthesia and Critical Care Medicine, Polyclinic Hospital Mangiagalli e Regina Elena IRCCS, University of Milan, Milan, Italy
    Minerva Anestesiol 74:315-8. 2008
    ..Since hypothermia has important side effects, further work is necessary before introducing this procedure into clinical practice for TBI...
  21. ncbi request reprint Intracranial pressure monitoring for traumatic brain injury: available evidence and clinical implications
    N Stocchetti
    Department of Anesthesia and Critical Care Medicine, University of Milan and Neuroscience ICU, Maggiore Policlinico IRCCS Hospital Milan, Italy
    Minerva Anestesiol 74:197-203. 2008
    ..The aim of this review was to evaluate the pros and cons of ICP monitoring and to discuss the hypothetical desirability and feasibility of a trial testing the benefits of ICP monitoring...
  22. ncbi request reprint [Cerebral oxygen consumption and ischemia in traumatic brain injury]
    N Stocchetti
    Terapia Intensiva Neuroscienze, Ospedale Maggiore Policlinico IRCCS, Universita degli Studi di Milano, Milano, Italy
    Minerva Anestesiol 70:207-11. 2004
    ..The incidence of ischemia and the meaning of post-traumatic metabolic alterations are still unclear...
  23. ncbi request reprint Brain oxygen tension, oxygen supply, and oxygen consumption during arterial hyperoxia in a model of progressive cerebral ischemia
    S Rossi
    Department of Anesthesia and Intensive Care, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    J Neurotrauma 18:163-74. 2001
    ..However, this relation is not necessarily reciprocal, since manipulating brain oxygen tension does not always influence brain oxygen delivery, as in the case of ventilation with pure oxygen...
  24. ncbi request reprint Effect of traumatic brain injury on cognitive function in mice lacking p55 and p75 tumor necrosis factor receptors
    L Longhi
    Neurosurgical Intensive Care Unit, Department of Anesthesia and Critical Care Medicine, Fondazione IRCCS Ospedale Maggiore Policlinico, University of Milano, Mangiagalli e Regina Elena, Milano, Italy
    Acta Neurochir Suppl 102:409-13. 2008
    ....
  25. ncbi request reprint Intracranial hypertension in head injury: management and results
    N Stocchetti
    Department of Anesthesia and Intensive Care, Ospedale Maggiore, Policlinico IRCCS, Milano, Italy
    Intensive Care Med 25:371-6. 1999
    ....
  26. doi request reprint Intensive care for pediatric traumatic brain injury
    A Sigurtà
    Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Neurointensive Care Unit and University of Milan, Milan, Italy
    Intensive Care Med 39:129-36. 2013
    ....
  27. ncbi request reprint Effects of hyperoxia on brain tissue oxygen tension in cerebral focal lesions
    L Longhi
    Department of Anesthesia and Intensive Care, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    Acta Neurochir Suppl 81:315-7. 2002
    ..01) was found when mean PtiO2 was 31.7 +/- 14.3 mmHg. Since O2 diffusion should follow the gas diffusion law, the increase in diffusion distance due to a reduction of capillary density in focal lesions may explain this relationship...
  28. ncbi request reprint The ratio between arterio-venous PCO2 difference and arterio-jugular oxygen difference as estimator of critical cerebral hypoperfusion
    E R Zanier
    Department of Anesthesiology and Intensive Care, Ospedale Maggiore IRCCS, University of Milan, Milan, Italy
    Minerva Anestesiol 72:543-9. 2006
    ....
  29. ncbi request reprint Intensive care management of head-injured patients in Europe: a survey from the European brain injury consortium
    N Stocchetti
    Terapia Intensiva Neuroscienze, Serv Anestesia e Rianimazione Ospedale Policlinico IRCCS, Via Francesco Sforza 35, 20122 Milan, Italy
    Intensive Care Med 27:400-6. 2001
    ....
  30. ncbi request reprint Early translaryngeal tracheostomy in patients with severe brain damage
    N Stocchetti
    Department Anesthesia and Intensive Care, Neuroscience Intensive Care, Policlinico Hospital IRCCS, Milan, Italy
    Intensive Care Med 26:1101-7. 2000
    ....
  31. pmc Brain temperature, body core temperature, and intracranial pressure in acute cerebral damage
    S Rossi
    Department of Anesthesia and Intensive Care, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    J Neurol Neurosurg Psychiatry 71:448-54. 2001
    ..Moreover, Tc may underestimate ICT during the phases when temperature has the most impact on the intracranial system because of the close association between increases in ICT and ICP...
  32. ncbi request reprint Increased levels of CSF heart-type fatty acid-binding protein and tau protein after aneurysmal subarachnoid hemorrhage
    E R Zanier
    Neurosurgical Intensive Care Unit, Department of Anesthesia and Critical Care Medicine, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milano, Milano, Italy
    Acta Neurochir Suppl 102:339-43. 2008
    ..The goal of this study was to measure H-FABP and tau in cerebrospinal fluid (CSF) following SAH to test the hypothesis that a relationship exists between SAH severity and H-FABP/tau values...
  33. ncbi request reprint [Brain vulnerability and its modulation]
    L Longhi
    Terapia Intensiva Neuroscienze, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    Minerva Anestesiol 69:227-31. 2003
    ..Additional work is needed to better understand the molecular pathways leading to secondary damage and to find novel therapeutic strategies to modulate the brain response to TBI...
  34. ncbi request reprint Cerebral veno-arterial pCO2 difference as an estimator of uncompensated cerebral hypoperfusion
    S Rossi
    Department of Anesthesia and Intensive Care, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    Acta Neurochir Suppl 81:201-4. 2002
    ..Therefore, when the brain's ability to compensate for low blood flow is exceeded, CO2 production outweighs O2 extraction...
  35. ncbi request reprint Awake neurosurgery: an update
    V Conte
    Neuroscience Intensive Care Unit, Polyclinic Hospital Mangiagalli e Regina Elena IRCCS, University of Milan, Milan, Italy
    Minerva Anestesiol 74:289-92. 2008
    ....
  36. pmc Mass volume measurement in severe head injury: accuracy and feasibility of two pragmatic methods
    N Stocchetti
    Neuroscience Intensive Care, Policlinico Hospital IRCCS Milano, Italy
    J Neurol Neurosurg Psychiatry 68:14-7. 2000
    ..To assess the clinical feasibility and the accuracy of two pragmatic methods in comparison with a conventional computer based method of measurement of masses from CT...
  37. ncbi request reprint Improving the quality of data entry in a low-budget head injury database
    L Beretta
    Neurointensive Care Unit, IRCCS Ospedale S Raffaele, Milano, Italy
    Acta Neurochir (Wien) 149:903-9. 2007
    ..To assess the efficacy of a centralised review of a voluntary low-budget head injury database with a retrospective analysis of data before and after a centralised review...
  38. ncbi request reprint Neuroprotective effect of C1-inhibitor following traumatic brain injury in mice
    L Longhi
    Department of Anesthesia and Critical Care Medicine, Ospedale Maggiore Policlinico, Neurosurgical Intensive Care Unit, Via Sforza n 35, 20122 Milano, Italy
    Acta Neurochir Suppl 102:381-4. 2008
    ....
  39. ncbi request reprint Monitoring brain tissue oxygen tension in brain-injured patients reveals hypoxic episodes in normal-appearing and in peri-focal tissue
    Luca Longhi
    University of Milano, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Neurosurgical Intensive Care Unit, Department of Anesthesia and Critical Care Medicine, Via Sforza n 35, 20100 Milan, Italy
    Intensive Care Med 33:2136-42. 2007
    ..We compared brain tissue oxygen tension (PtiO2) measured in peri-focal and in normal-appearing brain parenchyma on computerized tomography (CT) in patients following traumatic brain injury (TBI)...
  40. ncbi request reprint Application of guidelines for severe head trauma: data from an Italian database
    Giuseppe Citerio
    Dipartimento di Anestesia e Rianimazione, Nuovo Ospedale San Gerardo, Monza, Milan, Italy
    Eur J Emerg Med 10:68-72. 2003
  41. ncbi request reprint Stem cell transplantation as a therapeutic strategy for traumatic brain injury
    Luca Longhi
    Milan University, Neurosurgical Intensive Care Unit, Department of Anesthesia and Critical Care Medicine, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano, Italy
    Transpl Immunol 15:143-8. 2005
    ..We believe that further work must continue to better understand the interaction between the host and the transplanted cells as well as the mechanisms regulating their differentiation into mature and functionally active neurons/glia...
  42. ncbi request reprint Alpha-melanocyte-stimulating hormone is decreased in plasma of patients with acute brain injury
    Sandra Magnoni
    Department of Anesthesia and Intensive Care, Ospedale Maggiore di Milano IRCCS, Milano, Italy
    J Neurotrauma 20:251-60. 2003
    ..The data raise the possibility that restoration of normal circulating alpha-MSH through administration of the peptide could be beneficial in patients with brain injury...
  43. ncbi request reprint Oxygen and carbon dioxide in the cerebral circulation during progression to brain death
    Nino Stocchetti
    Department of Anesthesia and Critical Care Medicine, Milan University, Italy
    Anesthesiology 103:957-61. 2005
    ..When brain infarction develops, the metabolism will be abated, no oxygen will be consumed, and no carbon dioxide will be produced...
  44. doi request reprint Spectral analysis of heart rate variability during asleep-awake craniotomy for tumor resection
    Valeria Conte
    Neuroscience ICU, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena IRCCS, Milan University, Milan, Italy
    J Neurosurg Anesthesiol 21:242-7. 2009
    ..This information might help in tailoring the protocol and the duration of awake phase according to the individual autonomic response...
  45. ncbi request reprint Temporal window of vulnerability to repetitive experimental concussive brain injury
    Luca Longhi
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Neurosurgery 56:364-74; discussion 364-74. 2005
    ..Repetitive concussive brain injury (CBI) is associated with cognitive alterations and increased risk of neurodegenerative disease...
  46. doi request reprint Analysis of propofol/remifentanil infusion protocol for tumor surgery with intraoperative brain mapping
    Valeria Conte
    Neuroscience Intensive Care Unit, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena IRCCS, Milan University, Italy
    J Neurosurg Anesthesiol 22:119-27. 2010
    ..Objective of this study was to prospectively collect and evaluate data about a large series of consecutive asleep-awake and asleep-asleep craniotomies...
  47. doi request reprint Bryan Jennett and the field of traumatic brain injury. His intellectual and ethical heritage in neuro-intensive care
    Nino Stocchetti
    Neuroscience Intensive Care Unit, University of Milan, Ospedale Maggiore Policlinico, Mangiagalli, e Regina Elena, Fondazione IRCCS, Milan, Italy
    Intensive Care Med 34:1774-8. 2008
    ..This paper is meant to gratefully acknowledge his contributions and to reflect on the implications that his work has for neuro-intensive care today...
  48. ncbi request reprint Intraoperative language localization in multilingual patients with gliomas
    Lorenzo Bello
    Department of Neurological Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Neurosurgery 59:115-25; discussion 115-25. 2006
    ....
  49. ncbi request reprint Pyrexia in head-injured patients admitted to intensive care
    Nino Stocchetti
    Terapia Intensiva Neuroscienze, Ospedale Maggiore, Policlinico IRCCS, Via S Sforza, 3520 122 Milan, Italy
    Intensive Care Med 28:1555-62. 2002
    ....
  50. ncbi request reprint Hyperoxia in head injury: therapeutic tool?
    Luca Longhi
    University of Milano, Department of Anesthesia and Critical Care Medicine, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
    Curr Opin Crit Care 10:105-9. 2004
    ..In this article, we present the principles of oxygen transport to the brain, the effects of hyperoxia on cerebral metabolism, and the role of lactate in brain metabolism after traumatic brain injury...
  51. ncbi request reprint Lack of improvement in cerebral metabolism after hyperoxia in severe head injury: a microdialysis study
    Sandra Magnoni
    Department of Anesthesia and Intensive Care, Milan University, Italy
    J Neurosurg 98:952-8. 2003
    ..The authors investigated the effects of hyperoxia on brain tissue PO2 and on glucose metabolism in cerebral and adipose tissue after traumatic brain injury (TBI)...
  52. ncbi request reprint Intraoperative subcortical language tract mapping guides surgical removal of gliomas involving speech areas
    Lorenzo Bello
    Department of Neurological Sciences, University of Milan, Milan, Italy
    Neurosurgery 60:67-80; discussion 80-2. 2007
    ....
  53. ncbi request reprint Traumatic subarachnoid hemorrhage on the computerized tomography scan obtained at admission: a multicenter assessment of the accuracy of diagnosis and the potential impact on patient outcome
    Cristina Mattioli
    Neurointensive Care Unit, Neuroradiology Department, IRCCS H San Raffaele, Milano, Italy
    J Neurosurg 98:37-42. 2003
    ....
  54. ncbi request reprint [Neuro-link, an Italian traumatic coma data bank: what did we learn from the first 1000 patients and how can we do better? ]
    I Beretta
    Neurorianimazione, Istituto Scientifico, H S Raffaele, Milano, Italy
    Minerva Anestesiol 69:223-6. 2003
    ..Audit is performed on 35 000 data per year.A large number of good quality information on head injury patients is now available. The database is useful for: 1) production of information; 2) base for prospective studies...
  55. ncbi request reprint Cortical and subcortical motor mapping in rolandic and perirolandic glioma surgery: impact on postoperative morbidity and extent of resection
    G Carrabba
    Department of Neurosurgery, University of Milan, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS Foundation, Milan, Italy
    J Neurosurg Sci 51:45-51. 2007
    ..In this study we evaluated the effect which subcortical motor mapping had on postoperative morbidity and extent of resection in a series of patients with gliomas involving motor areas or pathways...
  56. doi request reprint c-Jun N-terminal kinase pathway activation in human and experimental cerebral contusion
    Fabrizio Ortolano
    Department of Neuroscience, Mario Negri Institute Università di Milan, Neurosurgical Intensive Care Unit, Department of Anesthesia and Critical Care Medicine, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    J Neuropathol Exp Neurol 68:964-71. 2009
    ....
  57. ncbi request reprint Ethical implications of time frames in a randomized controlled trial in acute severe traumatic brain injury
    Erwin J O Kompanje
    Department of Intensive Care, Erasmus MC University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands, and Ospedale Policlinico IRCCS, Milan, Italy
    Prog Brain Res 161:243-50. 2007
    ..To analyze factors determining the time between injury and study drug administration (SDA) in a randomized controlled trial (RCT) of acute severe traumatic brain injury (TBI) and to discuss the ethical implications...
  58. ncbi request reprint Add-on phenytoin fails to prevent early seizures after surgery for supratentorial brain tumors: a randomized controlled study
    Antonio de Santis
    Institute of Neurosurgery, Policlinico IRCCS, University of Milan, Italy
    Epilepsia 43:175-82. 2002
    ..To determine the potential effectiveness of phenytoin (PHT) in preventing early postoperative seizures in patients undergoing craniotomy for supratentorial brain tumors...
  59. doi request reprint C1-inhibitor attenuates neurobehavioral deficits and reduces contusion volume after controlled cortical impact brain injury in mice
    Luca Longhi
    Department of Anesthesia and Critical Care Medicine, Neurosurgical Intensive Care Unit, University of Milano, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano, Italy
    Crit Care Med 37:659-65. 2009
    ..The aim of the study was to evaluate the effects of C1-inhibitor (C1-INH), an endogenous inhibitor of complement and kinin systems, on neurobehavioral and histological outcome following controlled cortical impact brain injury...
  60. doi request reprint Questioning the value of intracranial pressure (ICP) monitoring in patients with brain injuries
    Andrew I Maas
    J Trauma 65:966-7. 2008
  61. ncbi request reprint Traumatic subarachnoid hemorrhage: demographic and clinical study of 750 patients from the European brain injury consortium survey of head injuries
    Franco Servadei
    Divisione di Neurochirurgia per la Traumatologia, Ospedale Maurizio Bufalini, Cesena, Italy
    Neurosurgery 50:261-7; discussion 267-9. 2002
    ..The mechanism underlying the link between tSAH and prognosis has not been clarified. The aim of this study was to investigate the association between CT evidence of tSAH and outcomes after moderate or severe head injuries...
  62. pmc Classification of traumatic brain injury for targeted therapies
    Kathryn E Saatman
    University of Kentucky, Lexington, KY, USA
    J Neurotrauma 25:719-38. 2008
    ..Recommendations were made for enhancing the utility of available or emerging tools in order to facilitate implementation of a pathoanatomic classification approach for clinical trials...
  63. ncbi request reprint Management of 350 aneurysmal subarachnoid hemorrhages in 22 Italian neurosurgical centers
    Guiseppe Citerio
    Ospedale San Gerardo, Neurorianimazione, Dipartimento di Medicina Perioperatoria e Terapie Intensive, Via Pergolesi 33, 20052 Monza, Italy
    Intensive Care Med 33:1580-6. 2007
    ..To collect information on clinical practice and current management strategies in 22 Italian neurosurgical hospitals for patients with aneurysmal subarachnoid hemorrhage...
  64. ncbi request reprint Moving from macro- to microcirculation in head injury
    Nino Stocchetti
    Crit Care Med 32:1429-30. 2004
  65. ncbi request reprint Less autoregulation and more flow in subarachnoid hemorrhage
    Nino Stocchetti
    Stroke 38:e69; author reply e70. 2007
  66. ncbi request reprint Consensus meeting on microdialysis in neurointensive care
    Bo Michael Bellander
    Section of Neurosurgery, Department of Clinical Neuroscience, Karolinska Institutet and Hospital, Stockholm, Sweden
    Intensive Care Med 30:2166-9. 2004
    ..Microdialysis is used in many European neurointensive care units to monitor brain chemistry in patients suffering subarachnoid hemorrhage (SAH) or traumatic brain injury (TBI)...
  67. ncbi request reprint Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice
    Luca Longhi
    Veterans Administration Medical Center, Philadelphia, Pennsylvania, USA
    J Neurotrauma 21:1723-36. 2004
    ..These data suggest that NGF gene therapy using transduced NT2N neurons (as a source of delivery) may selectively improve cognitive function following TBI...
  68. ncbi request reprint Salt saves the hot brain?
    Nino Stocchetti
    Intensive Care Med 29:1409-10. 2003
  69. ncbi request reprint Motor and cognitive function evaluation following experimental traumatic brain injury
    Scott T Fujimoto
    Department of Neurosurgery, University of Pennsylvania, 3320 Smith Walk, 105C Hayden Hall, Philadelphia, PA 19104 6316, USA
    Neurosci Biobehav Rev 28:365-78. 2004
    ..The goal of this review is to describe and evaluate the tests employed to assess functional outcome after TBI and to overview aspects of cognitive, sensory, and motor function that may be suitable targets for therapeutic intervention...
  70. ncbi request reprint New European directive on clinical trials: implications for traumatic head injury research
    Nino Stocchetti
    Intensive Care Med 30:517-8. 2004
  71. ncbi request reprint Comment on "Levels of vancomycin in the cerebral interstitial fluid after severe head injury" by Caricato et al
    Sandra Magnoni
    Intensive Care Med 32:1096; author reply 1095. 2006
  72. doi request reprint Moderate and severe traumatic brain injury in adults
    Andrew I R Maas
    Department of Neurosurgery, University Hospital Antwerp, Antwerp, Belgium
    Lancet Neurol 7:728-41. 2008
    ..Suggestions are provided for the way forward, with an emphasis on epidemiological monitoring, trauma organisation, and approaches to management...
  73. pmc TrkB gene transfer does not alter hippocampal neuronal loss and cognitive deficits following traumatic brain injury in mice
    Valeria Conte
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA
    Restor Neurol Neurosci 26:45-56. 2008
    ....
  74. ncbi request reprint Observer variation in the assessment of outcome in traumatic brain injury: experience from a multicenter, international randomized clinical trial
    J T Lindsay Wilson
    Department of Psychology, University of Stirling, Stirling, Scotland, United Kingdom
    Neurosurgery 61:123-8; discussion 128-9. 2007
    ..We aimed to explore observer variation in the assessment of outcome in a recently completed trial of dexanabinol in head injury and to consider steps to reduce such variation...
  75. ncbi request reprint Could intracranial pressure in traumatic brain injury be measured or predicted noninvasively? Almost
    Nino Stocchetti
    Intensive Care Med 33:1682-3. 2007