Antonio Pedotti

Summary

Affiliation: Ospedale Maggiore
Country: Italy

Publications

  1. ncbi request reprint Lung recruitment in patients with the acute respiratory distress syndrome
    Luciano Gattinoni
    Istituto di Anestesiologia e Rianimazione, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, Universita degli Studi di Milano, Milan, Italy
    N Engl J Med 354:1775-86. 2006
  2. doi request reprint Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome
    Davide Chiumello
    Dipartimento di Anestesia, Rianimazione, Intensiva e Subintensivae, Terapia del Dolore, Fondazione IRCCS, Ospedale Maggiore Policlinico Mangiagalli Regina Elena di Milano, Milan, Italy
    Am J Respir Crit Care Med 178:346-55. 2008
  3. ncbi request reprint The concept of "baby lung"
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, Universita degli Studi, Milan, Italy
    Intensive Care Med 31:776-84. 2005
  4. ncbi request reprint Monitoring of pulmonary mechanics in acute respiratory distress syndrome to titrate therapy
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano IRCCS, Universita degli Studi di Milano, Milano, Italy
    Curr Opin Crit Care 11:252-8. 2005
  5. ncbi request reprint Prone positioning improves survival in severe ARDS: a pathophysiologic review and individual patient meta-analysis
    L Gattinoni
    Department of Anesthesia, Intensive e Subintensive Resuscitation and Pain Therapy, Cà Granda Foundation, Ospedale Maggiore Policlinico, Milan, Italy
    Minerva Anestesiol 76:448-54. 2010
  6. doi request reprint Body position changes redistribute lung computed-tomographic density in patients with acute respiratory failure: impact and clinical fallout through the following 20 years
    Luciano Gattinoni
    Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti, Universita degli Studi di Milano, Via F Sforza 35, 20122, Milan, Italy
    Intensive Care Med 39:1909-15. 2013
  7. pmc Clinical review: Respiratory monitoring in the ICU - a consensus of 16
    Laurent Brochard
    Department of Intensive Care, Hopitaux Universitaires de Geneve, Rue Gabrielle Perret Gentil 4, 1211 Geneva, Switzerland
    Crit Care 16:219. 2012
  8. pmc Supporting hemodynamics: what should we target? What treatments should we use?
    Luciano Gattinoni
    Dipartimento di Anestesia, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    Crit Care 17:S4. 2013
  9. doi request reprint Towards ultraprotective mechanical ventilation
    Luciano Gattinoni
    Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy
    Curr Opin Anaesthesiol 25:141-7. 2012
  10. pmc Clinical review: Extracorporeal membrane oxygenation
    Luciano Gattinoni
    Dipartimento di Anestesia, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    Crit Care 15:243. 2011

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint Lung recruitment in patients with the acute respiratory distress syndrome
    Luciano Gattinoni
    Istituto di Anestesiologia e Rianimazione, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, Universita degli Studi di Milano, Milan, Italy
    N Engl J Med 354:1775-86. 2006
    ....
  2. doi request reprint Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome
    Davide Chiumello
    Dipartimento di Anestesia, Rianimazione, Intensiva e Subintensivae, Terapia del Dolore, Fondazione IRCCS, Ospedale Maggiore Policlinico Mangiagalli Regina Elena di Milano, Milan, Italy
    Am J Respir Crit Care Med 178:346-55. 2008
    ..Lung injury caused by a ventilator results from nonphysiologic lung stress (transpulmonary pressure) and strain (inflated volume to functional residual capacity ratio)...
  3. ncbi request reprint The concept of "baby lung"
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, Universita degli Studi, Milan, Italy
    Intensive Care Med 31:776-84. 2005
    ....
  4. ncbi request reprint Monitoring of pulmonary mechanics in acute respiratory distress syndrome to titrate therapy
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano IRCCS, Universita degli Studi di Milano, Milano, Italy
    Curr Opin Crit Care 11:252-8. 2005
    ..This paper reviews recent findings regarding the respiratory mechanics during acute respiratory distress syndrome as a tool for tailoring its ventilatory management...
  5. ncbi request reprint Prone positioning improves survival in severe ARDS: a pathophysiologic review and individual patient meta-analysis
    L Gattinoni
    Department of Anesthesia, Intensive e Subintensive Resuscitation and Pain Therapy, Cà Granda Foundation, Ospedale Maggiore Policlinico, Milan, Italy
    Minerva Anestesiol 76:448-54. 2010
    ..On the other hand, all data suggest that long-term prone positioning may expose patients with less severe ARDS to unnecessary complications...
  6. doi request reprint Body position changes redistribute lung computed-tomographic density in patients with acute respiratory failure: impact and clinical fallout through the following 20 years
    Luciano Gattinoni
    Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti, Universita degli Studi di Milano, Via F Sforza 35, 20122, Milan, Italy
    Intensive Care Med 39:1909-15. 2013
    ..Finally, and a series of clinical trials led to the conclusion that in patients with severe ARDS, the prone position provides a significant survival advantage. ..
  7. pmc Clinical review: Respiratory monitoring in the ICU - a consensus of 16
    Laurent Brochard
    Department of Intensive Care, Hopitaux Universitaires de Geneve, Rue Gabrielle Perret Gentil 4, 1211 Geneva, Switzerland
    Crit Care 16:219. 2012
    ..In this consensus paper, we provide an overview of the important parameters that can and should be monitored in the critically ill patient with respiratory failure and discuss how the data provided can impact on clinical management...
  8. pmc Supporting hemodynamics: what should we target? What treatments should we use?
    Luciano Gattinoni
    Dipartimento di Anestesia, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    Crit Care 17:S4. 2013
    ..To avoid changes in acid-base equilibrium the strong ion difference of the infused solution should be equal to the baseline bicarbonate concentration...
  9. doi request reprint Towards ultraprotective mechanical ventilation
    Luciano Gattinoni
    Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy
    Curr Opin Anaesthesiol 25:141-7. 2012
    ..To survey the causes of ventilator-induced lung injury focusing on its mechanical determinants, lung stress and strain...
  10. pmc Clinical review: Extracorporeal membrane oxygenation
    Luciano Gattinoni
    Dipartimento di Anestesia, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    Crit Care 15:243. 2011
    ..The current enthusiasm for ECMO in its various aspects should not, however, obscure the consideration of the potential complications associated with this life-saving technique, primarily brain hemorrhage...
  11. doi request reprint Stress and strain within the lung
    Luciano Gattinoni
    Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy
    Curr Opin Crit Care 18:42-7. 2012
    ..To describe the physiological meaning and the clinical application of the lung stress and strain concepts...
  12. pmc Effect of a heated humidifier during continuous positive airway pressure delivered by a helmet
    Davide Chiumello
    Unità Operativa di Anestesia e Rianimazione, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Via F, Sforza 35, 20122 Milan, Italy
    Crit Care 12:R55. 2008
    ..We evaluated the temperature and humidity of respiratory gases inside the helmet, with and without a heated humidifier, during continuous positive airway pressure (CPAP) delivered with a helmet...
  13. pmc Oxygen consumption is depressed in patients with lactic acidosis due to biguanide intoxication
    Alessandro Protti
    Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena di Milano, Universita degli Studi di Milano, Via F, Sforza 35, 20122 Milan, Italy
    Crit Care 14:R22. 2010
    ..To verify this hypothesis, we investigated whether body oxygen consumption (VO2), that primarily depends on mitochondrial respiration, is depressed in patients with biguanide intoxication...
  14. pmc Effects of thoraco-pelvic supports during prone position in patients with acute lung injury/acute respiratory distress syndrome: a physiological study
    Davide Chiumello
    Dipartimento di Anestesia e Rianimazione, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Via F, Sforza 35, 20122 Milan, Italy
    Crit Care 10:R87. 2006
    ....
  15. pmc Prevalence of endotoxemia after surgery and its association with ICU length of stay
    Franco Valenza
    Dipartimento di Anestesia, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS Ospedale Maggiore Policlinico Mangiagalli Regina Elena, 20122 Milano, Italy
    Crit Care 13:R102. 2009
    ..The aim of this observational study was to investigate the prevalence of endotoxemia after surgery and its association with ICU length of stay...
  16. pmc Nitrogen washout/washin, helium dilution and computed tomography in the assessment of end expiratory lung volume
    Davide Chiumello
    Dipartimento di Anestesia, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS Ospedale Maggiore Policlinico Mangiagalli Regina Elena, Via Francesco Sforza 35, 20122, Milano, Italy
    Crit Care 12:R150. 2008
    ..We compared the EELV measured by spiral computed tomography (CT) taken as gold standard with the lung volume measured with the modified nitrogen washout/washin and with the helium dilution technique...
  17. pmc The effect of different volumes and temperatures of saline on the bladder pressure measurement in critically ill patients
    Davide Chiumello
    Dipartimento di Anestesia e Rianimazione, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Via F Sforza 35, 20122 Milan, Italy
    Crit Care 11:R82. 2007
    ..The aim of this study was to evaluate the effect of different volumes and temperatures of infused saline on bladder pressure measurements in comparison with gastric pressure...
  18. doi request reprint Assessing gas exchange in acute lung injury/acute respiratory distress syndrome: diagnostic techniques and prognostic relevance
    Luciano Gattinoni
    Dipartimento di Anestesia, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico di Milano, Italy
    Curr Opin Crit Care 17:18-23. 2011
    ..To provide the most recent insights on the assessment of gas exchange in acute lung injury...
  19. ncbi request reprint [Albumin administration: volume replacement or pharmacological treatment?]
    L Gattinoni
    Istituto di Anestesia e Rianimazione, Universita degli Studi di Milano, Fondazione IRCCS, Ospedale Maggiore Policlinico Mangiagalli, Regina Elena di Milano
    Minerva Anestesiol 71:27-40. 2005
  20. ncbi request reprint Acute respiratory distress syndrome, the critical care paradigm: what we learned and what we forgot
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Universita degli Studi di Milano, Ospedale Policlinico IRCCS, Milano, Italy
    Curr Opin Crit Care 10:272-8. 2004
    ..Measurements of variables as transpulmonary pressure and end expiratory lung volume, for a rational setting of mechanical ventilation, should be introduced in routine clinical practice...
  21. pmc Bench-to-bedside review: chest wall elastance in acute lung injury/acute respiratory distress syndrome patients
    Luciano Gattinoni
    Institute of Anesthesia and Critical Care, University of Milan, Policlinico IRCCS Hospital, Milan, Italy
    Crit Care 8:350-5. 2004
    ..It is always important in the most critically ill patients to assess the intra-abdominal pressure and the chest wall elastance...
  22. pmc Strong ion difference in urine: new perspectives in acid-base assessment
    Luciano Gattinoni
    Dipartimento di Anestesia, Rianimazione, e Terapia del Dolore, Fondazione IRCCS Ospedale Maggiore Policlinico, Istituto di Anestesiologia e Rianimazione, Universita degli Studi di Milano, Milano, Italy
    Crit Care 10:137. 2006
    ..A thorough understanding of acid-base equilibrium mandates recognition of the importance of urinary SID...
  23. ncbi request reprint How to ventilate patients with acute lung injury and acute respiratory distress syndrome
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano IRCCS, Universita degli Studi di Milano, Milano, Italy
    Curr Opin Crit Care 11:69-76. 2005
    ..The purpose of this paper is to review the mechanisms of ventilator-induced lung injury as a basis for providing the less damaging mechanical ventilation in patients with acute respiratory failure...
  24. doi request reprint Positive end-expiratory pressure
    Luciano Gattinoni
    Dipartimento di Anestesia, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS Ospedale Maggiore Policlinico Mangiagalli Regina Elena di Milano, Milan, Italy
    Curr Opin Crit Care 16:39-44. 2010
    ..In the last 2 years, several reports have dealt with recruitment/positive end-expiratory pressure (PEEP) selection. Most of them confirm previous results and few add new information...
  25. ncbi request reprint Pulmonary computed tomography and adult respiratory distress syndrome
    Luciano Gattinoni
    Istituto de Anestesia e Rianimazione, Universita degli Studi di Milano, Ospedale Policlinico IRCCS, Italy
    Swiss Med Wkly 135:169-74. 2005
    ..In this brief review we will emphasize the most relevant new knowledge achieved using CT scanning and we will briefly discuss its clinical use in ARDS patients...
  26. doi request reprint Ventilator-induced lung injury: the anatomical and physiological framework
    Luciano Gattinoni
    Dipartimento di Anestesiologia, Universita degli Studi di Milano, Milan, Italy
    Crit Care Med 38:S539-48. 2010
    ..We believe that ventilator-induced lung injury occurs only when a given threshold is exceeded; below this limit, mechanical ventilation is likely to be safe...
  27. ncbi request reprint Physical and biological triggers of ventilator-induced lung injury and its prevention
    L Gattinoni
    Institute of Anaesthesia and Intensive Care, University of Milan, Policlinico Hospital, IRCCS, Milan, Italy
    Eur Respir J Suppl 47:15s-25s. 2003
    ....
  28. ncbi request reprint Effects of recombinant human activated protein C on the fibrinolytic system of patients undergoing conventional or tight glycemic control
    F Polli
    Institute of Anesthesia and Intensive Care, University of Milan, Milan, Italy
    Minerva Anestesiol 75:417-26. 2009
    ..Our aim was to evaluate the effects on the fibrinolytic system after the administration of rh-APC in septic patients undergoing conventional or TGC...
  29. ncbi request reprint The role of CT-scan studies for the diagnosis and therapy of acute respiratory distress syndrome
    Luciano Gattinoni
    Istituto di Anestesiologia e Rianimazione, Dipartimento di Anestesia, Rianimazione, e Terapia del Dolore, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Universita degli Studi di Milano, Milano, Italy
    Clin Chest Med 27:559-70; abstract vii. 2006
    ..CT assessment of lung recruitability seems to be a prerequisite for a rational setting of positive end-expiratory pressure...
  30. pmc Ventilation in the prone position: for some but not for all?
    Luciano Gattinoni
    Istituto di Anestesiologia e Rianimazione, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Universita degli Studi di Milano, Italy
    CMAJ 178:1174-6. 2008
  31. ncbi request reprint Decrease in PaCO2 with prone position is predictive of improved outcome in acute respiratory distress syndrome
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Universita degli Studi di Milano, Ospedale Policlinico, Milan, Italy
    Crit Care Med 31:2727-33. 2003
    ..To determine whether gas exchange improvement in response to the prone position is associated with an improved outcome in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS)...
  32. doi request reprint Dilutional acidosis: where do the protons come from?
    Luciano Gattinoni
    Dipartimento di Anestesia, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS, Ospedale Maggiore Policlinico Mangiagalli Regina Elena di Milano, Milan, Italy
    Intensive Care Med 35:2033-43. 2009
    ..To investigate the mechanism of acidosis developing after saline infusion (dilutional acidosis or hyperchloremic acidosis)...
  33. ncbi request reprint Effect of prone positioning on the survival of patients with acute respiratory failure
    L Gattinoni
    Istituto di Anestesia e Rianimazione, Universita di Milano, Ospedale Maggiore di Milano, Milan, Italy
    N Engl J Med 345:568-73. 2001
    ..Although placing patients with acute respiratory failure in a prone (face down) position improves their oxygenation 60 to 70 percent of the time, the effect on survival is not known...
  34. ncbi request reprint Estimation of end-expiratory lung volume variations by optoelectronic plethysmography
    R L Dellaca
    Dipartimento di Bioingegneria Politecnico Di Milano and the Centro di Bioingegneria, Fond Don Gnocchi IRCCS, Politecnico di Milano, Milano, Italy
    Crit Care Med 29:1807-11. 2001
    ..To test the capability of optoelectronic plethysmography (OEP) to monitor positive end-expiratory pressure (PEEP)-induced changes of end-expiratory lung volume (EELV) changes in mechanically ventilated paralyzed patients...
  35. ncbi request reprint Recruitment and derecruitment during acute respiratory failure: a clinical study
    S Crotti
    Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
    Am J Respir Crit Care Med 164:131-40. 2001
    ..When superimposed gravitational pressure exceeded PEEP, end-expiratory collapse increased. We concluded that the rules governing recruitment and derecruitment equally apply in an oleic acid model and in human ALI/ARDS...
  36. ncbi request reprint Kidney instant monitoring (K.IN.G): a new analyzer to monitor kidney function
    P Caironi
    Department of Anesthesiology, Intensive Care Unit and Dermatological Sciences, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, University of Milan, Milan, Italy
    Minerva Anestesiol 76:316-24. 2010
    ..Accordingly, we developed and tested a urine analyzer, allowing quasi-continuous urinary analysis...
  37. ncbi request reprint An improved in vivo rat model for the study of mechanical ventilatory support effects on organs distal to the lung
    F Valenza
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano IRCCS, Italy
    Crit Care Med 28:3697-704. 2000
    ....
  38. ncbi request reprint Different modes of assisted ventilation in patients with acute respiratory failure
    D Chiumello
    Istituto di Anestesia e Rianimazione, Universita degli Studi di Milano, Ospedale Policlinico IRCCS, Italy
    Eur Respir J 20:925-33. 2002
    ..During assist control, tidal volume and peak inspiratory flow (set by the physician) are the main determinants of the patient/ventilator interaction...
  39. doi request reprint The rule regulating pH changes during crystalloid infusion
    E Carlesso
    Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Universita degli Studi, Milan, Italy
    Intensive Care Med 37:461-8. 2011
    ..To define the rule according to which crystalloid solutions characterized by different strong ion difference (SID) modify the acid-base variables of human plasma...
  40. ncbi request reprint Effects of carbon dioxide insufflation for laparoscopic cholecystectomy on the respiratory system
    P Pelosi
    Department of Anaesthesia and Intensive Care, University of Milan, Ospedale Maggiore IRCCS, Italy
    Anaesthesia 51:744-9. 1996
    ..These changes were not affected by the duration of anaesthesia...
  41. pmc Rib cage deformities alter respiratory muscle action and chest wall function in patients with severe osteogenesis imperfecta
    Antonella Lomauro
    TBMLab, Dipartimento di Bioingegneria, Politecnico di Milano, Milano, Italy
    PLoS ONE 7:e35965. 2012
    ..Cardiopulmonary insufficiency is the leading cause of death in these patients...
  42. pmc Chest wall mechanics during pressure support ventilation
    Andrea Aliverti
    Dipartimento di Bioingegneria, Politecnico di Milano, Milano, Italy
    Crit Care 10:R54. 2006
    ....
  43. ncbi request reprint Recruitment and derecruitment during acute respiratory failure: an experimental study
    P Pelosi
    Istituto di Anestesia e Rianimazione, , Ospedale Maggiore Policlinico-IRCCS, Milan, Italy
    Am J Respir Crit Care Med 164:122-30. 2001
    ..86, p < 0.0001), suggesting that as more tissue is recruited at end-inspiration, more remains recruited at end-expiration. When superimposed pressure exceeded applied airway pressure (Paw), collapse significantly increased...
  44. doi request reprint Assessment of dynamic mechanical properties of the respiratory system during high-frequency oscillatory ventilation*
    Raffaele L Dellaca
    1TBM Lab, Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano University, Milano, Italy 2Neonatal Intensive Care Unit, MBBM Foundation, Monza, Italy 3Department of Health Sciences, Universita di Milano Bicocca, Monza, Italy
    Crit Care Med 41:2502-11. 2013
    ....
  45. doi request reprint Concomitant ventilatory and circulatory functions of the diaphragm and abdominal muscles
    Andrea Aliverti
    TBM Lab, Dipartimento di Bioingegneria, Politecnico di Milano, Milano, Italy
    J Appl Physiol (1985) 109:1432-40. 2010
    ..These combined functions of the diaphragm have potential for cardiopulmonary resuscitation. The abdominal circulatory pump can act as an auxiliary heart...
  46. ncbi request reprint 3D optoelectronic analysis of interfractional patient setup variability in frameless extracranial stereotactic radiotherapy
    Guido Baroni
    Department of Bioengineering, Politecnico di Milano University, Milan, Italy
    Int J Radiat Oncol Biol Phys 64:635-42. 2006
    ..To investigate size and frequency of interfractional patient setup variability in hypofractionated stereotactic extracranial radiotherapy...
  47. ncbi request reprint Positive end-expiratory pressure applied to the dependent lung during one-lung ventilation improves oxygenation and respiratory mechanics in patients with high FEV1
    F Valenza
    Istituto di Anestesia e Rianimazione, Milan, Italy
    Eur J Anaesthesiol 21:938-43. 2004
    ..The aim of this study was to test the efficacy of positive end-expiratory pressure (PEEP) to the dependent lung during one-lung ventilation, taking into consideration underlying lung function in order to select responders to PEEP...
  48. ncbi request reprint Positive end-expiratory pressure delays the progression of lung injury during ventilator strategies involving high airway pressure and lung overdistention
    Franco Valenza
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano, Italy
    Crit Care Med 31:1993-8. 2003
    ..This study, however, set out to investigate the protective role of PEEP with respect to the time needed to reach similar levels of lung injury...
  49. ncbi request reprint Intra-abdominal pressure may be decreased non-invasively by continuous negative extra-abdominal pressure (NEXAP)
    Franco Valenza
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Universita degli Studi di Milano, Via F Sforza 35, 20122, Milan, Italy
    Intensive Care Med 29:2063-7. 2003
    ..To investigate the possibility of artificially decreasing intra-abdominal pressure (IAP) by applying continuous negative pressure around the abdomen...
  50. ncbi request reprint Sepsis: state of the art
    L Gattinoni
    Department of Anesthesiology, Ospedale Maggiore Policlinico IRCCS, Milano University of Milan, Milan, Italy
    Minerva Anestesiol 69:539-54, 554-61. 2003
    ..Multinodal modulation of several interdependent processes may be the probable reason for the proven effectiveness of this treatment...
  51. doi request reprint A validation study of a new nasogastric polyfunctional catheter
    D Chiumello
    Dipartimento di Anestesia, Rianimazione, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Intensive Care Med 37:791-5. 2011
    ..We compared the Pes and IGP measured using this new device with those obtained with a standard balloon catheter taken as gold standard...
  52. ncbi request reprint Effects of volume shift on the pressure-volume curve of the respiratory system in ALI/ARDS patients
    D Chiumello
    Department of Anesthesia and Intensive Care, IRCCS Foundation, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Milan, Italy
    Minerva Anestesiol 73:109-18. 2007
    ..Another possible confounding factor is the volume shift, primarily blood, out of the chest wall when the intrathoracic pressures rise. We set out to quantify the volume shift and investigate its mechanisms...
  53. ncbi request reprint Prone position delays the progression of ventilator-induced lung injury in rats: does lung strain distribution play a role?
    Franco Valenza
    Universita degli Studi di Milano, Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano IRCCS, Via F Sforza 35, 20122 Milano, Italy
    Crit Care Med 33:361-7. 2005
    ..To investigate if prone position delays the progression of experimental ventilator-induced lung injury, possibly due to a more homogeneous distribution of strain within lung parenchyma...
  54. pmc Positive end-expiratory pressure optimization with forced oscillation technique reduces ventilator induced lung injury: a controlled experimental study in pigs with saline lavage lung injury
    Peter Kostic
    Dipartimento di Bioingegneria, Politecnico di Milano University, Piazza Leonardo da Vinci 32, Milan, Italy
    Crit Care 15:R126. 2011
    ..The aim of the present study was to evaluate if using Xrs for setting PEEP would improve lung mechanics and reduce lung injury compared to an oxygenation-based approach...
  55. ncbi request reprint Feasibility, limits and problems of clinical studies in Intensive Care Unit
    G Grasselli
    Department of Perioperative Medicine and Intensive Care, San Gerardo Hospital, University Milano Bicocca, Milan, Italy
    Minerva Anestesiol 73:595-601. 2007
    ..Few suggestions are formulated which could help looking forwards...
  56. ncbi request reprint Prolongation of antibiotic prophylaxis after clean and clean-contaminated surgery and surgical site infection
    S De Chiara
    Department of General Resuscitation, Institute of Anesthesia and Resuscitation University of Milan, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy
    Minerva Anestesiol 76:413-9. 2010
    ..In this observational study, we evaluated the risk of surgical site infection (SSI) associated with the prolongation of AMP after clean and clean-contaminated surgery...
  57. ncbi request reprint The ratio between arterio-venous PCO2 difference and arterio-jugular oxygen difference as estimator of critical cerebral hypoperfusion
    E R Zanier
    Department of Anesthesiology and Intensive Care, Ospedale Maggiore IRCCS, University of Milan, Milan, Italy
    Minerva Anestesiol 72:543-9. 2006
    ....
  58. pmc Lactate as a marker of energy failure in critically ill patients: hypothesis
    Franco Valenza
    Istituto di Anestesia e Rianimazione, Universita degli Studi di Milano, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena Fondazione IRCCS di Natura Pubblica, Milan, Italy
    Crit Care 9:588-93. 2005
    ..Conversely, once the mitochondria are deranged, energy failure occurs even in the presence of normoxia. The lactate increase in critically ill patients may therefore be viewed as an early marker of a potentially reversible state...
  59. ncbi request reprint Case of exogenous lipoid pneumonia: steroid therapy and lung lavage with an emulsifier
    Riccarda Russo
    Istituto di Anestesia e Rianimazione, Fondazione Instituto di Ricovero e Cura a Carattere Scientifico IRCCS, Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Milano, Italy
    Anesthesiology 104:197-8. 2006
  60. ncbi request reprint Reduced tidal volumes and lung protective ventilatory strategies: where do we go from here?
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Universita degli Studi di Milano, Ospedale Policlinico IRCCS, Milano, Italy
    Curr Opin Crit Care 8:45-50. 2002
    ..Full" protective lung strategy was tested in only one study and in a limited number of patients. Several physiologic studies strongly suggest the advantages of the lung protective strategy...
  61. ncbi request reprint [Use of positive end-expiratory pressure in acute respiratory distress syndrome: current views]
    Pietro Caironi
    Istituto di Anestesiologia e Rianimazione, Dipartimento di Anestesia, Rianimazione e Terapia del Dolore, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano
    Recenti Prog Med 98:509-17. 2007
    ..At present, computed tomography represents the most accurate technique for its measurement...
  62. doi request reprint Relationship between gas exchange response to prone position and lung recruitability during acute respiratory failure
    Alessandro Protti
    Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena di Milano, Universita degli Studi di Milano, Via F Sforza 35, 20122 Milan, Italy
    Intensive Care Med 35:1011-7. 2009
    ..To clarify whether the gas exchange response to prone position is associated with lung recruitability in mechanically ventilated patients with acute respiratory failure...
  63. pmc The abdominal circulatory pump
    Andrea Aliverti
    Dipartimento di Bioingegneria, Politecnico di Milano, Milan, Italy
    PLoS ONE 4:e5550. 2009
    ..During asystolic cardiac arrest we calculate that appropriate timing of abdominal compression could produce an output of 6 L/min. so that the abdominal circulatory pump might act as an auxiliary heart...
  64. pmc Actual performance of mechanical ventilators in ICU: a multicentric quality control study
    Leonardo Govoni
    TBM Lab, Dipartimento di Bioingegneria, Politecnico di Milano University, Milano, Italy
    Med Devices (Auckl) 5:111-9. 2012
    ..In several cases, the actual delivered mechanical ventilation was considerably different from the set one, suggesting the need for improving quality control procedures for these machines...
  65. pmc Changes in the mechanical properties of the respiratory system during the development of interstitial lung edema
    Raffaele L Dellaca
    TBM Lab, Dipartimento di Bioingegneria, Politecnico di Milano University, Milano, Italy
    Respir Res 9:51. 2008
    ..Our aim was to investigate the impact of the early stages of the development of interstitial edema on the mechanical properties of the respiratory system...
  66. doi request reprint The consumption of glucose during ex vivo lung perfusion correlates with lung edema
    F Valenza
    Dipartimento di Anestesia, Terapia Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Transplant Proc 43:993-6. 2011
    ..Ex vivo lung perfusion (EVLP) has been recently proposed to recondition organs before transplantation from donors with marginal or unacceptable features. The aim of our investigation was to explore glucose consumption during EVLP...
  67. ncbi request reprint Respiratory acidosis: is the correction with bicarbonate worth?
    L Gattinoni
    Institute of Anesthesia and Intensive Care, University of Milan, Milan, Italy
    Minerva Anestesiol 72:551-7. 2006
    ..The effect is independent on (HCO3-) infusion and equivalent to adding (Na+ OH-) instead of (Na+ HCO3-)...
  68. ncbi request reprint Gastric tonometry
    E Carlesso
    Institute of Anesthesia and Intensive Care, University of Milan, Milan, Italy
    Minerva Anestesiol 72:529-32. 2006
    ..In this brief review we will discuss the value of the gastric tonometry, its physiological background and the clinical results observed so far...
  69. ncbi request reprint Heat stress: characteristics, pathophysiology and avoidable mistakes
    M L Caspani
    Intensive Care Unit, IRCCS Ospedale Maggiore Policlinico, Department of Anesthesia and Intensive Care, University of Milan, Milan, Italy
    Minerva Anestesiol 70:617-24. 2004
    ..The comparative analysis of these 2 studies suggests that the time of intervention may lead to significant differences in mortality. In these patients time is essential...
  70. doi request reprint Prone positioning in patients with moderate and severe acute respiratory distress syndrome: a randomized controlled trial
    Paolo Taccone
    Dipartimento di Anestesia e Rianimazione, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, 20122 Milan, Italy
    JAMA 302:1977-84. 2009
    ..Post hoc analysis of a previous trial has suggested that prone positioning may improve survival in patients with severe hypoxemia and with acute respiratory distress syndrome (ARDS)...
  71. pmc In vitro and in vivo evaluation of a new active heat moisture exchanger
    Davide Chiumello
    Institute of Anesthesia and Critical Care, University of Milan, Policlinico Hospital, IRCCS, Milan, Italy
    Crit Care 8:R281-8. 2004
    ..In this study we evaluated the efficiency, both in vitro and in vivo, of a new active HME (the Performer; StarMed, Mirandola, Italy) as compared with that of existing HMEs (Hygroster and Hygrobac; Mallinckrodt, Mirandola, Italy)...
  72. doi request reprint Lung opening and closing during ventilation of acute respiratory distress syndrome
    Pietro Caironi
    Dipartimento di Anestesiologia, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy
    Am J Respir Crit Care Med 181:578-86. 2010
    ....
  73. ncbi request reprint Radiological imaging in acute lung injury and acute respiratory distress syndrome
    Pietro Caironi
    Dipartimento di Anestesia, Rianimazione, e Terapia del Dolore, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, Universita degli Studi di Milano, Milano, Italy
    Semin Respir Crit Care Med 27:404-15. 2006
    ..CT scans may also help to diagnose ARDS because CT provides a good estimate of the high-permeability lung edema, the characteristic lesion of this syndrome...
  74. ncbi request reprint How to monitor lung recruitment in patients with acute lung injury
    Pietro Caironi
    Istituto di Anestesiologia e Rianimazione, Dipartimento di Anestesia, Rianimazione, e Terapia del Dolore, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, Universita degli Studi di Milano, Milan, Italy
    Curr Opin Crit Care 13:338-43. 2007
    ..We review recent findings on this topic and attempt to provide a clinical approach to estimating lung recruitment...
  75. doi request reprint Telemetric CPAP titration at home in patients with sleep apnea-hypopnea syndrome
    Raffaele Dellaca
    TBMLab, Dipartimento di Bioingegneria, Politecnico di Milano, Milano, Italy
    Sleep Med 12:153-7. 2011
    ..Home continuous positive airway pressure (CPAP) titration with automatic devices is not possible in a non-negligible percentage of patients with sleep apnea-hypopnea syndrome (SAHS)...
  76. ncbi request reprint [The fluid balance in the critically ill patient]
    P Bruzzone
    Istituto di Anestesia e Rianimazione, Ospedale Policlinico, IRCCS, Universita degli Studi di Milano, Milano, Italy
    Minerva Anestesiol 70:431-6. 2004
    ..Aim of this study was to prospectively evaluate the accuracy of the fluid balance compared to the body weight measured by a dedicated mattress (Hill-Rom)...
  77. ncbi request reprint Management of mechanical ventilation during laparoscopic surgery
    Franco Valenza
    Universita degli Studi di Milano, Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Via Festa del Perdono n 7, Milano, Italy
    Best Pract Res Clin Anaesthesiol 24:227-41. 2010
    ..Ventilatory and non-ventilatory strategies to protect the lung are discussed...
  78. ncbi request reprint Physiologic rationale for ventilator setting in acute lung injury/acute respiratory distress syndrome patients
    Luciano Gattinoni
    Istituto di Anestesia e Rianimazione, Universita degli Studi di Milano, Ospedale Policlinico IRCCS, Milano, Italy
    Crit Care Med 31:S300-4. 2003
    ..To review the physiologic approach to setting mechanical ventilation in acute lung injury/acute respiratory distress syndrome...
  79. ncbi request reprint Static and dynamic components of esophageal and central venous pressure during intra-abdominal hypertension
    Franco Valenza
    Istituto di Anestesia e Rianimazione, Fondazione Policlinico Ospedale Maggiore, Mangiagalli e Regina Elena IRCCS, Milano, Italy
    Crit Care Med 35:1575-81. 2007
    ..To investigate the effects of intra-abdominal hypertension on esophageal and central venous pressure considering values obtained at end-expiration (i.e., in static conditions) and during tidal volume delivery (i.e., in dynamic conditions)...
  80. ncbi request reprint Effect of different inspiratory rise time and cycling off criteria during pressure support ventilation in patients recovering from acute lung injury
    Davide Chiumello
    Istituto di Anestesia e Reanimazione, Università degli Studi Milano, Ospedale Policlinico IRCSS, Milan, Italy
    Crit Care Med 31:2604-10. 2003
    ..This study evaluated the effect of different inspiratory rise time and cycling off criteria on breathing pattern and work of breathing...
  81. ncbi request reprint Effects of the beach chair position, positive end-expiratory pressure, and pneumoperitoneum on respiratory function in morbidly obese patients during anesthesia and paralysis
    Franco Valenza
    Istituto di Anestesia e Rianimazione, Fondazione Ospedale Maggiore, Mangiagalli e Regina Elena IRCCS, Milan, Italy
    Anesthesiology 107:725-32. 2007
    ..The authors studied the effects of the beach chair (BC) position, 10 cm H2O positive end-expiratory pressure (PEEP), and pneumoperitoneum on respiratory function in morbidly obese patients undergoing laparoscopic gastric banding...
  82. doi request reprint Acute lung injury/acute respiratory distress syndrome pathophysiology: what we have learned from computed tomography scanning
    Pietro Caironi
    Istituto di Anestesiologia e Rianimazione, Dipartimento di Anestesia, Rianimazione e Terapia del Dolore, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, Universita degli Studi di Milano, Milano, Italy
    Curr Opin Crit Care 14:64-9. 2008
    ..Here, we review recent findings derived from computed tomography scanning during acute respiratory distress syndrome, particularly concerning setting positive end-expiratory pressure and mechanisms of ventilator-induced lung injury...
  83. ncbi request reprint Dosimetric effects within target and organs at risk of interfractional patient mispositioning in left breast cancer radiotherapy
    Guido Baroni
    TBM Lab, Department of Bioengineering, Politecnico di Milano University, Milan, Italy
    Int J Radiat Oncol Biol Phys 59:861-71. 2004
    ..To investigate the effects of interfraction setup uncertainties on the dose distribution within the clinical target volume (CTV) and the organs at risk (OAR) of left-sided breast cancer patients undergoing external radiotherapy...
  84. ncbi request reprint A blunt complex abdominal trauma: total hepatectomy and liver transplantation
    D Chiumello
    Istituto di Anestesia e Rianimazione, Universita di Milano, Ospedale Policlinico IRCCS, Via Francesco Sforza, 35, 20122 Milano, Italy
    Intensive Care Med 28:89-91. 2002
    ..After 36 h in this anhepatic state, the patient received the new graft. The graft showed immediate recovery. In cases of severe and complex liver trauma, performing a total hepatectomy followed by liver transplantation is justified...
  85. ncbi request reprint Volume of activity and occupancy rate in intensive care units. Association with mortality
    Gaetano Iapichino
    Istituto di Anestesiologia e Rianimazione, Universita di Milano, Azienda Ospedaliera Polo Universitario San Paolo, Via A Di Rudini 8, 20142 Milan, Italy
    Intensive Care Med 30:290-7. 2004
    ..We examined the relationship between the volume of activity of intensive care units (ICUs) and mortality by a measure of risk-adjusted volume of activity specific for ICUs...
  86. ncbi request reprint Equal increases in respiratory system elastance reflect similar lung damage in experimental ventilator-induced lung injury
    Silvio Sibilla
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano, IRCCS, Via F Sforza n 35, 20122 Milan, Italy
    Intensive Care Med 28:196-203. 2002
    ..We hypothesized that a 50% increase in respiratory system elastance (Ers) would indicate similar degree of lung damage (equi-damage, ED), independently of ventilation strategy...
  87. doi request reprint Tight glycemic control does not affect asymmetric-dimethylarginine in septic patients
    Gaetano Iapichino
    Istituto di Anestesiologia e Rianimazione, Universita degli Studi di Milano, Via A Di Rudini 8, 20142 Milan, Italy
    Intensive Care Med 34:1843-50. 2008
    ..We investigated whether preventing hyperglycemia in septic patients affected the plasma concentration of asymmetric-dimethylarginine and if this was associated with clinical benefit...
  88. ncbi request reprint Effects of continuous negative extra-abdominal pressure on cardiorespiratory function during abdominal hypertension: an experimental study
    Franco Valenza
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore di Milano Istituto di Ricovero e Cura a Carattere Scientifico, Universita degli Studi di Milano, Via F Sforza 35, 20122 Milan, Italy
    Intensive Care Med 31:105-11. 2005
    ..To investigate whether negative extra-abdominal pressure (NEXAP) improves respiratory function and induces a blood shift from the intrathoracic compartment and to assess whether these effects are influenced by abdominal pressure...
  89. doi request reprint Tight glycemic control may favor fibrinolysis in patients with sepsis
    Monica Savioli
    Dipartimento di Anestesia, UO di Anestesia e Rianimazione, Rianimazione Intensiva e Subintensiva e Terapia del Dolore, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena di Milano, Milan, Italy
    Crit Care Med 37:424-31. 2009
    ..To investigate whether tight glycemic control, in patients with sepsis, may restore a normal fibrinolysis by lowering plasminogen activator inhibitor (PAI)-1 levels...
  90. ncbi request reprint Anatomical and functional intrapulmonary shunt in acute respiratory distress syndrome
    Massimo Cressoni
    Istituto di Anestesiologia e Rianimazione, Universita degli Studi di Milano, Milan, Italy
    Crit Care Med 36:669-75. 2008
    ..Therefore, we aimed to assess the value of venous admixture (functional shunt) in estimating the fraction of nonaerated lung tissue (anatomical shunt compartment) and to describe their relationship...
  91. doi request reprint Lung stress and strain during mechanical ventilation: any safe threshold?
    Alessandro Protti
    Dipartimento di Anestesiologia, Terapia Intensiva e Scienze Dermatologiche, Universita degli Studi di Milano, Milan, Italy
    Am J Respir Crit Care Med 183:1354-62. 2011
    ..Unphysiologic strain (the ratio between tidal volume and functional residual capacity) and stress (the transpulmonary pressure) can cause ventilator-induced lung damage...
  92. ncbi request reprint Effect of different cycling-off criteria and positive end-expiratory pressure during pressure support ventilation in patients with chronic obstructive pulmonary disease
    Davide Chiumello
    Dipartimento di Anestesia e Rianimazione, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Milan, Italy
    Crit Care Med 35:2547-52. 2007
    ..This study evaluated the effect of two different cycling-off criteria on breathing pattern, respiratory effort, and gas exchange in patients with chronic obstructive pulmonary disease...
  93. ncbi request reprint Noninvasive positive pressure ventilation delivered by helmet vs. standard face mask
    Davide Chiumello
    Istituto di Anestesia e Rianimazione, Ospedale Maggiore Policlinico IRCCS, Universita degli Studi di Milano, Via Francesco Sforza 35, 20122 Milan, Italy
    Intensive Care Med 29:1671-9. 2003
    ..This bench and human study compared large and small helmets with face mask (FM) for delivery of noninvasive positive pressure ventilation...
  94. ncbi request reprint A complication of amiodarone infusion
    Davide Chiumello
    Istituto di Anestesia e Rianimazione, Universita di Milano, Ospedale Policlinico IRCCS, Milan, Italy
    Eur J Emerg Med 11:102-4. 2004
    ..We hypothesized that this intravascular mass was due to a deposition of the Amiodarone during the infusion in the central line..
  95. ncbi request reprint Ventilatory management of acute respiratory distress syndrome: a consensus of two
    John J Marini
    University of Minnesota, Regions Hospital, St Paul 55101, USA
    Crit Care Med 32:250-5. 2004
    ..To synthesize the emerging body of experimental, observational, and clinical trial data into a practical guideline for safe and effective ventilatory management of acute respiratory distress syndrome...
  96. ncbi request reprint Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome
    Pier Paolo Terragni
    Universita di Torino, Dipartimento di Anestesiologia e Rianimazione, Ospedale S Giovanni Battista Molinette, Corso Dogliotti 14, 10126 Turin, Italy
    Am J Respir Crit Care Med 175:160-6. 2007
    ..Computed tomography demonstrated a small, normally aerated compartment on the top of poorly aerated and nonaerated compartments that may be hyperinflated by tidal inflation...
  97. ncbi request reprint An increase of abdominal pressure increases pulmonary edema in oleic acid-induced lung injury
    Michael Quintel
    Institut fur Anasthesiologie und Operative Intensivmedizin, Universitatsklinikum, Mannheim, Mannheim, Germany
    Am J Respir Crit Care Med 169:534-41. 2004
    ..We conclude that in OA-injured lung, the increase of IAP increases the amount of edema...
  98. doi request reprint Refining ventilatory treatment for acute lung injury and acute respiratory distress syndrome
    Luciano Gattinoni
    JAMA 299:691-3. 2008
  99. ncbi request reprint Sigh in supine and prone position during acute respiratory distress syndrome
    Paolo Pelosi
    Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi dell Insubria, Ospedale di Circolo, Fondazione Macchi, Varese
    Am J Respir Crit Care Med 167:521-7. 2003
    ..82, p < 0.001). We conclude that adding a recruitment maneuver such as cyclical sighs during ventilation in the prone position may provide optimal lung recruitment in the early stage of ARDS...
  100. ncbi request reprint Anemia and blood transfusion in critically ill patients
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, Brussels, 1070, Belgium
    JAMA 288:1499-507. 2002
    ..Anemia is a common problem in critically ill patients admitted to intensive care units (ICUs), but the consequences of anemia on morbidity and mortality in the critically ill is poorly defined...
  101. ncbi request reprint Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiological study
    Manu L N G Malbrain
    Intensive Care Unit Director, Medical Intensive Care Unit, Ziekenhuis Netwerk Antwerpen, Campus Stuivenberg, Lange Beeldekensstraat 267, B 2060 Antwerpen 6, Belgium
    Crit Care Med 33:315-22. 2005
    ....