Research Topics
Species | I MartinelliSummaryAffiliation: Ospedale Maggiore Country: Italy Publications
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Detail Information
Publications
Rare thromboses of cerebral, splanchnic and upper-extremity veins. A narrative reviewIda Martinelli
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, University of Milan, Milan, Italy
Thromb Haemost 103:1136-44. 2010..However, the recommendations for treatment mainly derive from observational studies...- Extra-abdominal venous thromboses at unusual sitesIda Martinelli
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialities, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
Best Pract Res Clin Haematol 25:265-74. 2012..However, such recommendations mainly derive from observational studies; there are no data about long-term treatment of retinal vein occlusion... - Cerebral sinus-venous thrombosisIda Martinelli
Department of Internal Medicine and Medical Specialities, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Via Pace, 9, 20122, Milan, Italy
Intern Emerg Med 7:221-5. 2012..However, the optimal duration of anticoagulant treatment is not well established, because limited information is available on the rate of CSVT recurrence after anticoagulant discontinuation... 
Identification of genetic risk variants for deep vein thrombosis by multiplexed next-generation sequencing of 186 hemostatic/pro-inflammatory genesLuca A Lotta
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, U O S Dipartimentale per la Diagnosi e la Terapia delle Coagulopatie, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy
BMC Med Genomics 5:7. 2012....
Embryo implantation after assisted reproductive procedures and maternal thrombophiliaIda Martinelli
A Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milano, Via Pace, 9, 20122 Milano, Italy
Haematologica 88:789-93. 2003....- Unusual forms of venous thrombosis and thrombophiliaIda Martinelli
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Italy
Pathophysiol Haemost Thromb 32:343-5. 2002..In conclusion, there is increasing evidence that inherited and environmental risk factors may interact differently in determining VTE in different sites... - Pharmacogenetic aspects of the use of oral contraceptives and the risk of thrombosisIda Martinelli
A Bianchi Bonomi Haemophilia and Thrombosis Center, IRCCS Ospedale Maggiore and University of Milan, Italy
Pharmacogenetics 13:589-94. 2003.... - Thrombotic risk factors: basic pathophysiologyIda Martinelli
A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Milan, Italy
Crit Care Med 38:S3-9. 2010..Typical examples of shared risk factors are age and the metabolic syndrome. This review addresses the mechanism whereby established risk factors increase the risk of venous or arterial thrombosis, or both... - High levels of factor VIII and risk of extra-hepatic portal vein obstructionIda Martinelli
Department of Internal Medicine and Medical Specialties, A Bianchi Bonomi Hemophilia and Thrombosis Center and Gastroenterology Unit, University of Milan and IRCCS Maggiore Hospital, Milan, Italy
J Hepatol 50:916-22. 2009..High levels of coagulation factor VIII are a risk factor for lower-limb deep vein thrombosis (DVT). Their role in extra-hepatic portal vein obstruction (EHPVO) is not established... - Risk factors and recurrence rate of primary deep vein thrombosis of the upper extremitiesIda Martinelli
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, University of Milano, Italy
Circulation 110:566-70. 2004..Risk factors for primary upper-extremity DVT are not well established, and the recurrence rate is unknown... - The risk of first venous thromboembolism during pregnancy and puerperium in double heterozygotes for factor V Leiden and prothrombin G20210AI Martinelli
A Bianchi Bonomi Haemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University of Milan and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milan, Italy
J Thromb Haemost 6:494-8. 2008..Hence, whether or not these women deserve antithrombotic prophylaxis when pregnant is unknown... - von Willebrand factor and factor VIII as risk factors for arterial and venous thrombosisIda Martinelli
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, IRCCS Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
Semin Hematol 42:49-55. 2005..These findings have no therapeutic implication, but they should be taken into account in the assessment of the individual risk profile... - Type and location of venous thromboembolism in patients with factor V Leiden or prothrombin G20210A and in those with no thrombophiliaI Martinelli
Department of Internal Medicine and Medical Specialties, Bianchi Bonomi Haemophilia and Thrombosis Center, IRCCS Maggiore Hospital Policlinico, Mangiagalli and Regina Elena Foundation and University of Milan, Milan, Italy
J Thromb Haemost 5:98-101. 2007..For prothrombin G20210A, data are scanty and controversial... - Thromboembolism in womenIda Martinelli
A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, Foundation IRCCS Policlinico, Mangiagalli and Regina Elena, University of Milan, Milan, Italy
Semin Thromb Hemost 32:709-15. 2006..In this review, the relationship between VTE and risk factors specifically of women is discussed, also in relation to coagulation abnormalities causing inherited thrombophilia... - Prothrombin A19911G polymorphism and the risk of venous thromboembolismI Martinelli
Department of Internal Medicine and Medical Specialties, A Bianchi Bonomi Haemophilia and Thrombosis Center, University of Milan, and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milan, Italy
J Thromb Haemost 4:2582-6. 2006..The A > G polymorphism at position 19911 of the prothrombin gene is associated with increased plasma prothrombin levels but its role as a risk factor for venous thromboembolism (VTE) is not established... - Long-term evaluation of the risk of recurrence after cerebral sinus-venous thrombosisIda Martinelli
A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
Circulation 121:2740-6. 2010..The clinical course of cerebral sinus-venous thrombosis (CSVT) is largely unknown because prospective studies with a long follow-up and with the goal to assess thrombosis recurrence rate and predisposing factors for recurrence are lacking... - Effect of prothrombin 19911 A>G polymorphism on the risk of cerebral sinus-venous thrombosisI Martinelli
A Bianchi Bonomi Haemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
Eur J Neurol 17:1482-5. 2010..Its role in cerebral sinus-venous thrombosis (CSVT) is not known... - Low risk of thrombosis in family members of patients with hyperhomocysteinaemiaIda Martinelli
Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Luigi Villa Foundation, IRCCS Maggiore Hospital and University of Milan, Via Pace 9, 20122 Milan, Italy
Br J Haematol 117:709-11. 2002..28% and 0.24%). The low prevalence of hyperhomocysteinaemia among relatives of patients with this metabolic disorder, and their low risk of thrombosis, do not justify family screening... - Oral contraceptive use, thrombophilia and their interaction in young women with ischemic strokeIda Martinelli
A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, University of Milan and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Italy
Haematologica 91:844-7. 2006..The risk of ischemic stroke in oral contraceptive users was 13 times higher in women who were also carriers of factor V Leiden and 9 times higher in those who also had hyperhomocysteinemia... - Hyperhomocysteinemia in cerebral vein thrombosisIda Martinelli
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore, University of Milan, Italy
Blood 102:1363-6. 2003..5 (95% CI, 5.7-67.3). In conclusion, hyperhomocysteinemia is associated with a 4-fold increased risk of cerebral vein thrombosis; whether or not its correction with vitamins reduces the risk of the disease remains to be demonstrated... - Risk of pregnancy-related venous thrombosis in carriers of severe inherited thrombophiliaI Martinelli
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Italy
Thromb Haemost 86:800-3. 2001..On the basis of these findings we recommend that these women receive anticoagulant prophylaxis at least in the postpartum, that should perhaps be extended to the whole pregnancy in homozygous carriers... - Different risks of thrombosis in four coagulation defects associated with inherited thrombophilia: a study of 150 familiesI Martinelli
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Epidemiology Unit, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
Blood 92:2353-8. 1998..In addition, individuals with factor V Leiden develop less severe thrombotic manifestations, such as superficial vein thrombosis... - The risk of venous thromboembolism in family members with mutations in the genes of factor V or prothrombin or bothI Martinelli
Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, IRCCS Maggiore Hospital, University of Milan, Italy
Br J Haematol 111:1223-9. 2000..Anticoagulant prophylaxis seems to be indicated only when transient risk factors for thrombosis coexist with mutations... - Inherited thrombophilia and first venous thromboembolism during pregnancy and puerperiumIda Martinelli
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Italy
Thromb Haemost 87:791-5. 2002..Among thrombophilic abnormalities, the prothrombin mutation was the weakest risk factor. Thrombosis occurred more frequently in puerperium than in pregnancy, whether or not thrombophilia was diagnosed... - The JAK2 V617F mutation in patients with cerebral venous thrombosisS M Passamonti
A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicina and Medical Specialties, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico and University of Milan, Milan, Italy
J Thromb Haemost 10:998-1003. 2012..It is currently unclear whether or not cerebral venous thrombosis, such as splanchnic venous thrombosis, can be the first manifestation of an underlying myeloproliferative neoplasm... - Low borderline plasma levels of antithrombin, protein C and protein S are risk factors for venous thromboembolismP Bucciarelli
A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Medicine and Medical Specialties, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico and University of Milan, Milan
J Thromb Haemost 10:1783-91. 2012..They are usually defined by laboratory cut-offs (in our setting 81, 70 and 63 IU dL(-1), respectively), which give only a rough idea of the VTE risk associated with plasma levels of these proteins... - Interaction between the G20210A mutation of the prothrombin gene and oral contraceptive use in deep vein thrombosisI Martinelli
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, and Epidemiology Unit, IRCCS Maggiore Hospital, University of Milan, Italy
Arterioscler Thromb Vasc Biol 19:700-3. 1999..We conclude that carriers of the prothrombin mutation who use oral contraceptives have a markedly increased risk of deep vein thrombosis, much higher than the risk conferred by either factor alone... - Mutations in coagulation factors in women with unexplained late fetal lossI Martinelli
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Istituto di Ricovero e Cura a Carattere Scientifico Maggiore Hospital, University of Milan, Italy
N Engl J Med 343:1015-8. 2000..Whether any of these mutations is associated with an increased risk of late fetal death is not known... - Plasma levels of activated protein C in healthy subjects and patients with previous venous thromboembolism: relationships with plasma homocysteine levelsM Cattaneo
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Institute of Internal Medicine, IRCCS Ospedale Maggiore, University of Milano, Italy
Arterioscler Thromb Vasc Biol 18:1371-5. 1998..This study indicates that APC plasma levels are sensitive markers of activation of the hemostatic system in vivo and that Hcy does not interfere with the activation of PC in vivo... - Genetic risk factors for superficial vein thrombosisI Martinelli
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Italy
Thromb Haemost 82:1215-7. 1999..Hence, a laboratory search of these alterations is recommended in patients with SVT, because it allows the identification of patients at high risk of DVT in whom antithrombotic prophylaxis is particularly warranted... - Influence of anticoagulant therapy with vitamin K antagonists on plasma levels of coagulation factor VIIISerena Maria Passamonti
Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre, Department of Internal Medicine and Medical Specialties, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation and University of Milan, Italy
Thromb Res 126:243-5. 2010..In order to avoid overestimation of FVIII levels, patients should be preferentially tested after VKA discontinuation... - High prevalence of hyperchomocysteinemia in patients with inflammatory bowel disease: a pathogenic link with thromboembolic complications?M Cattaneo
A Bianchi Bonomi Hemophilia and Thrombosis Center, and Department of Internal Medicine, IRCCS Ospedale Maggiore, University of Milano, Italy
Thromb Haemost 80:542-5. 1998..Since they may have impaired absorption of vitamins that regulate the metabolism of homocysteine, we tested the hypothesis that they have hyperhomocysteinemia, an established risk factor for arterial and venous thrombosis... - Risk factors for thrombophilia in extrahepatic portal vein obstructionMassimo Primignani
Gastroenterology and Gastrointestinal Endoscopy Service, Department of Internal Medicine and Dermatology, IRCCS Maggiore Hospital and University of Milano, Milan, Italy
Hepatology 41:603-8. 2005..In conclusion, the risk for EHPVO is increased in the presence of thrombophilia resulting from the prothrombin G20210A mutation and from the deficiencies of the naturally occurring anticoagulant proteins, but not from factor V Leiden... - A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolismArmando Tripodi
Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
Blood 104:3631-4. 2004..In conclusion, hypercoagulability detected by a shortened APTT is independently associated with VTE. This inexpensive and simple test should be considered in the evaluation of the risk of VTE... - Pros and cons of thrombophilia testing: prosI Martinelli
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and Department of Internal Medicine, University of Milan, Italy
J Thromb Haemost 1:410-1. 2003 - The relationship between plasma homocysteine levels and bone mineral density in post-menopausal womenPaolo Bucciarelli
A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Medicine and Medical Specialties, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
Eur J Intern Med 21:301-5. 2010..Whether or not mild hyperhomocysteinemia and low serum levels of folates or vitamin B12 are risk factors for osteoporosis in the elderly is controversial... - Risk of venous thromboembolism after air travel: interaction with thrombophilia and oral contraceptivesIda Martinelli
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Istituto di Ricovero e Cura a Carattere Scientifico, Maggiore Hospital, University of Milan, Milan, Italy
Arch Intern Med 163:2771-4. 2003..To our knowledge, there are no studies investigating whether individuals with thrombophilia and those taking oral contraceptives are more likely to develop venous thromboembolism during flights than those without these risk factors... - Risk factors in venous thromboembolismI Martinelli
Department of Internal Medicine, IRCCS Maggiore Hospital, University of Milan, Italy
Thromb Haemost 86:395-403. 2001..Prevention of first events and recurrences of venous thromboembolism can be optimized only through a knowledge of the main risk factors, their effect, and their interaction with environmental factors... - Hormone therapy and thromboembolic diseaseTullia Battaglioli
A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, IRCCS Policlinico, Mangiagalli and Regina Elena Foundation, University of Milan, Italy
Curr Opin Hematol 14:488-93. 2007..To reduce this risk, changes in dosage, composition and route of administration have been made over the years. This review provides a summary of the available evidence and an update on the most recent findings on the issue... - How I treat rare venous thrombosesIda Martinelli
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Medicine and Medical Specialties, University of Milan, Milan, Italy
Blood 112:4818-23. 2008..The implementation of large interdisciplinary registries is a necessary weapon to optimize the treatment of rare venous diseases... - Psychological impact of thrombosis in the youngDiletta Fiandaca
Department of Medicine and Medical Specialties, Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, University of Milan and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
Intern Emerg Med 1:119-26. 2006..This is particularly evident in women and in young patients. Physicians dealing with thrombosis should be aware of this situation and offer psychological support... - Living near major traffic roads and risk of deep vein thrombosisAndrea Baccarelli
EPOCA Research Center for Environmental and Occupational Epidemiology, Department of Environmental and Occupational Health, Via San Barnaba 8, 20122 Milan, Italy
Circulation 119:3118-24. 2009..We investigated whether living near major traffic roads increases the risk of deep vein thrombosis (DVT), using distance from roads as a proxy for traffic exposure... - Economy-class syndrome: media hype or real risk?Ida Martinelli
Haematologica 88:486-8. 2003 - Recurrent late fetal death in women with and without thrombophiliaIda Martinelli
Thromb Haemost 87:358-9. 2002 - Screening of thrombophilia in women with failure of embryo implantation: far from being recommendedIda Martinelli
Haematologica 88:ELT36. 2003 - Polymorphisms of the protein Z-dependent protease inhibitor (ZPI) gene and the risk of venous thromboembolismCristina Razzari
Thromb Haemost 95:909-10. 2006 - Combined estrogen-progestin oral contraceptivesIda Martinelli
N Engl J Med 350:307-8; author reply 307-8. 2004 - Exposure to particulate air pollution and risk of deep vein thrombosisAndrea Baccarelli
Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Arch Intern Med 168:920-7. 2008..Particulate air pollution has been linked to heart disease and stroke, possibly resulting from enhanced coagulation and arterial thrombosis. Whether particulate air pollution exposure is related to venous thrombosis is unknown... - The risk of recurrent venous thromboembolism in pregnancy and puerperium without antithrombotic prophylaxisValerio De Stefano
Institute of Haematology, Catholic University, Rome, Italy
Br J Haematol 135:386-91. 2006..7-31.4) in overall carriers of factor V Leiden and 30% (95%CI 10.7-60.3) in carriers with a pregnancy-related first VTE, with a risk 6.8 times higher than in women without thrombophilia and with a non pregnancy-related first VTE... - Pregnancy-associated deep vein thrombosis in a double homozygous carrier of factor V Leiden and prothrombin G20210AAngelo Luigi Beretta
Internal Medicine Unit, Valduce Hospital Como, Italy
Thromb Haemost 94:1329-30. 2005 - Marburg I polymorphism of factor VII-activating protease and risk of venous thromboembolismFranca Franchi
Blood 107:1731. 2006 - Molecular characterization of an Italian patient with plasminogen deficiency and ligneous conjunctivitisSimona M Siboni
Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, University of Milan, Milan, Italy
Blood Coagul Fibrinolysis 18:81-4. 2007..By this simple strategy the complete sequence analysis of PLG gene was performed, and a previously reported missense homozygous mutation (K19E) was identified... 
Air pollution, smoking, and plasma homocysteineAndrea Baccarelli
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 115:176-81. 2007..Air pollution exposure induces short-term inflammatory changes that may determine hyperhomocysteinemia, particularly in the presence of a preexisting proinflammatory status such as that found in cigarette smokers...- The endogenous thrombin potential and the risk of venous thromboembolismArmando Tripodi
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
Thromb Res 121:353-9. 2007.... - Annexin V C/T-1 polymorphism and pregnancy complicationsFranca Franchi
Haematologica 91:864. 2006..The presence of the -1 CT or TT genotype did not show a protective effect in normal pregnancies... - Haemostatic activation in HIV infected patients treated with different antiretroviral regimensAngelo Pan
Istituto di Malattie Infettive e Tropicali, Spedali Civili, Universita di Brescia, Brescia, Italy
Curr HIV Res 6:70-6. 2008..In conclusion, a) HIV infection per se may alter the haemostatic markers of cardiovascular risk, b) minor differences were observed among the different classes of HIV infected patients, namely between NNRTI and PI treated patients... - Inherited thrombophilia and pregnancy complications revisitedMarc A Rodger
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Obstet Gynecol 112:320-4. 2008....