Stefano La Rosa

Summary

Affiliation: Ospedale di Circolo
Country: Italy

Publications

  1. pmc Localization of carboxyl ester lipase in human pituitary gland and pituitary adenomas
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    J Histochem Cytochem 58:881-9. 2010
  2. ncbi request reprint The applications of FISH in tumor pathology
    M G Tibiletti
    Department of Pathology, Ospedale di Circolo University of Insubria, Varese, Italy
    Adv Clin Path 3:111-8. 1999
  3. doi request reprint TTF1 expression in normal lung neuroendocrine cells and related tumors: immunohistochemical study comparing two different monoclonal antibodies
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, 21100 Varese, Italy
    Virchows Arch 457:497-507. 2010
  4. ncbi request reprint Prognostic and biological significance of cytokeratin 19 in pancreatic endocrine tumours
    S La Rosa
    Department of Pathology, Ospedale di Circolo, University of Insubria, Varese, Italy
    Histopathology 50:597-606. 2007
  5. ncbi request reprint Ultrastructural evidence of Tropheryma whippelii in PAS-negative granulomatous lymph nodes
    Giovanna Finzi
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    Ultrastruct Pathol 31:169-72. 2007
  6. doi request reprint Characterization of c-kit (CD117) expression in human normal pituitary cells and pituitary adenomas
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, Varese, Italy
    Endocr Pathol 19:104-11. 2008
  7. doi request reprint Improved histologic and clinicopathologic criteria for prognostic evaluation of pancreatic endocrine tumors
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, 21100 Varese, Italy
    Hum Pathol 40:30-40. 2009
  8. doi request reprint The monoclonal anti-BCL10 antibody (clone 331.1) is a sensitive and specific marker of pancreatic acinar cell carcinoma and pancreatic metaplasia
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100, Varese, Italy
    Virchows Arch 454:133-42. 2009
  9. doi request reprint Primary small cell neuroendocrine carcinoma of the kidney: morphological, immunohistochemical, ultrastructural, and cytogenetic study of a case and review of the literature
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100, Varese, Italy
    Endocr Pathol 20:24-34. 2009
  10. ncbi request reprint Morphological and ultrastructural features of human islet grafts performed in diabetic nude mice
    Giovanna Finzi
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    Ultrastruct Pathol 29:525-33. 2005

Collaborators

Detail Information

Publications46

  1. pmc Localization of carboxyl ester lipase in human pituitary gland and pituitary adenomas
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    J Histochem Cytochem 58:881-9. 2010
    ....
  2. ncbi request reprint The applications of FISH in tumor pathology
    M G Tibiletti
    Department of Pathology, Ospedale di Circolo University of Insubria, Varese, Italy
    Adv Clin Path 3:111-8. 1999
    ..The interphasic FISH may be extremely informative in tumor pathology even if the results are dependent on a good technical quality and adequate controls...
  3. doi request reprint TTF1 expression in normal lung neuroendocrine cells and related tumors: immunohistochemical study comparing two different monoclonal antibodies
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, 21100 Varese, Italy
    Virchows Arch 457:497-507. 2010
    ..In addition, the expression of TTF1 in normal NE cells suggests a possible role for the transcription factor in their development and differentiation...
  4. ncbi request reprint Prognostic and biological significance of cytokeratin 19 in pancreatic endocrine tumours
    S La Rosa
    Department of Pathology, Ospedale di Circolo, University of Insubria, Varese, Italy
    Histopathology 50:597-606. 2007
    ..The aim of this study was to evaluate the prognostic value of CK19 expression in PETs...
  5. ncbi request reprint Ultrastructural evidence of Tropheryma whippelii in PAS-negative granulomatous lymph nodes
    Giovanna Finzi
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    Ultrastruct Pathol 31:169-72. 2007
    ..This case confirms the role of the electron microscopy in the diagnosis of Whipple disease, especially for extra-intestinal lesions and at the initial phase of the disease, when the characteristic PAS-positive macrophages can be absent...
  6. doi request reprint Characterization of c-kit (CD117) expression in human normal pituitary cells and pituitary adenomas
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, Varese, Italy
    Endocr Pathol 19:104-11. 2008
    ..By contrast, all ten prolactin cell and seven growth hormone cell adenomas were c-kit negative. These data suggest that, in normal conditions, c-kit may be involved in the pituitary-adrenal axis regulation...
  7. doi request reprint Improved histologic and clinicopathologic criteria for prognostic evaluation of pancreatic endocrine tumors
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, 21100 Varese, Italy
    Hum Pathol 40:30-40. 2009
    ..The TNM system proved to be highly predictive of patient outcome and easy to combine with histologic and clinicopathologic parameters to classify pancreatic endocrine tumors into groups of increasing malignant potential...
  8. doi request reprint The monoclonal anti-BCL10 antibody (clone 331.1) is a sensitive and specific marker of pancreatic acinar cell carcinoma and pancreatic metaplasia
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100, Varese, Italy
    Virchows Arch 454:133-42. 2009
    ..We suggest using BCL10 antibody for diagnosing pancreatic tumors and whenever an acinar differentiation is suspected in gastrointestinal neoplastic and metaplastic lesions...
  9. doi request reprint Primary small cell neuroendocrine carcinoma of the kidney: morphological, immunohistochemical, ultrastructural, and cytogenetic study of a case and review of the literature
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100, Varese, Italy
    Endocr Pathol 20:24-34. 2009
    ....
  10. ncbi request reprint Morphological and ultrastructural features of human islet grafts performed in diabetic nude mice
    Giovanna Finzi
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    Ultrastruct Pathol 29:525-33. 2005
    ..The authors conclude that islet graft failure may be due to an insufficient beta cell mass related to their distress probably caused by anoxia and/or overstimulation...
  11. doi request reprint Thyroid metastases from typical carcinoid of the lung differentiating between medullary thyroid carcinoma and neuroendocrine tumor metastasis to the thyroid
    Stefano La Rosa
    Department of Pathology, Circle Hospital, Viale Borri 57, Varese, Italy
    Thyroid 19:521-6. 2009
    ..The most problematic differential diagnosis is with medullary thyroid carcinoma (MTC), a well-differentiated neuroendocrine tumor showing cytological and histological features similar to those of a lung carcinoid...
  12. ncbi request reprint Localization of myosin XVA in endocrine tumors of gut and pancreas
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    Endocr Pathol 13:29-37. 2002
    ..Although the role of this protein in endocrine cells is unknown, previous studies suggest that it may have a role in secretory granule movement and/or hormone secretion...
  13. ncbi request reprint Involvement of 1p36 region in two cases of adenocarcinoma of the ampulla of Vater
    Barbara Bernasconi
    Department of Pathology, Ospedale di Circolo, University of Insubria, Varese, Italy
    Cancer Genet Cytogenet 138:133-8. 2002
    ..In these tumors, the 1p36 region may play a relevant role in the progression towards a high grade of anaplasia...
  14. doi request reprint Ghrelin-producing well-differentiated neuroendocrine tumor (carcinoid) of tailgut cyst. Morphological, immunohistochemical, ultrastructural, and RT-PCR study of a case and review of the literature
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy
    Endocr Pathol 21:190-8. 2010
    ..In addition, we have accurately reviewed the literature on presacral carcinoids, associated or unassociated with tailgut cysts, to give the reader a comprehensive overview of these very rare tumor types...
  15. ncbi request reprint CDX2 as a marker of intestinal EC-cells and related well-differentiated endocrine tumors
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo and University of Insubria, Varese, Italy
    Virchows Arch 445:248-54. 2004
    ..We conclude that CDX2 may be considered a sensitive and specific marker of midgut EC-cells and EC-cell tumors, and its expression may be useful in the diagnosis of metastases from occult ETs...
  16. doi request reprint Clinicopathologic study of 62 acinar cell carcinomas of the pancreas: insights into the morphology and immunophenotype and search for prognostic markers
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, 21100 Varese, Italy
    Am J Surg Pathol 36:1782-95. 2012
    ..In addition, vascular and perineural invasion and CK19 and p53 expression showed a trend for poor prognosis, not reaching statistical significance...
  17. ncbi request reprint Different molecular profiles characterize well-differentiated endocrine tumors and poorly differentiated endocrine carcinomas of the gastroenteropancreatic tract
    Daniela Furlan
    Department of Human Morphology, University of Insubria and Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy
    Clin Cancer Res 10:947-57. 2004
    ..The purpose of this work was a molecular characterization of 38 gastroenteropancreatic ETs with respect to the primary site and to the morphofunctional profile, pointing out useful diagnostic or prognostic molecular markers...
  18. ncbi request reprint Ghrelin expression in gut endocrine growths
    Guido Rindi
    Department of Pathology, University of Brescia, Italy
    Histochem Cell Biol 117:521-5. 2002
    ..We conclude that ghrelin cells may take part in gut endocrine growths, with special reference to well-differentiated endocrine tumours of the stomach, independently from associated signs of endocrine hyperfunction...
  19. pmc Mixed exocrine-neuroendocrine carcinoma of the nasal cavity: clinico-pathologic and molecular study of a case and review of the literature
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy
    Head Neck Pathol 7:76-84. 2013
    ..We have also reviewed the literature on sinonasal mixed exocrine-neuroendocrine carcinomas to give to the reader a comprehensive overview of these very rare tumor types...
  20. doi request reprint Diagnostic utility of MS-MLPA in DNA methylation profiling of adenocarcinomas and neuroendocrine carcinomas of the colon-rectum
    Daniela Furlan
    Department of Surgical and Morphological Sciences, Anatomic Pathology Unit, University of Insubria and Ospedale di Circolo, Via O Rossi, 9, 21100, Varese, Italy
    Virchows Arch 462:47-56. 2013
    ..Aberrant gene methylation is a common abnormality in CRC initiation and may be observed in tumors with very different genetic and clinicopathological profiles...
  21. ncbi request reprint Localization of inhibins and activins in normal endocrine cells and endocrine tumors of the gut and pancreas: an immunohistochemical and in situ hybridization study
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo
    J Histochem Cytochem 52:217-25. 2004
    ....
  22. doi request reprint Neuroendocrine carcinomas of the breast
    Francesca Rovera
    Department of Surgical Sciences, University of Insubria, Varese, Italy
    Int J Surg 6:S113-5. 2008
    ..They are rare lesions representing about 2-3% of all breast cancers and affecting more frequently elderly patients...
  23. doi request reprint Serotonin-producing enterochromaffin cell tumors of the pancreas: clinicopathologic study of 15 cases and comparison with intestinal enterochromaffin cell tumors
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    Pancreas 40:883-95. 2011
    ..This study analyzes the clinicopathologic features of a series of pancreatic EC cell neoplasms and their similarities to and differences from intestinal EC cell tumors...
  24. ncbi request reprint Ghrelin expression and actions: a novel peptide for an old cell type of the diffuse endocrine system
    Guido Rindi
    Department of Pathology, University of Parma, Italy
    Exp Biol Med (Maywood) 229:1007-16. 2004
    ..This review aims to summarize recent data on ghrelin cell distribution in the diffuse endocrine system and discuss local and general ghrelin function during development, adulthood, and endocrine tumor development...
  25. ncbi request reprint Localization of vascular endothelial growth factor and its receptors in digestive endocrine tumors: correlation with microvessel density and clinicopathologic features
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    Hum Pathol 34:18-27. 2003
    ....
  26. doi request reprint Colonic carcinoma with a pancreatic acinar cell differentiation. A case report
    Anna Maria Chiaravalli
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100, Varese, Italy
    Virchows Arch 455:527-31. 2009
    ..There was no evidence of a pancreatic acinar cell carcinoma or of heterotopic pancreatic tissue. A colonic origin ought to be suspected when a metastatic carcinoma of unknown primary shows an acinar differentiation...
  27. doi request reprint Histologic changes in type A chronic atrophic gastritis indicating increased risk of neuroendocrine tumor development: the predictive role of dysplastic and severely hyperplastic enterochromaffin-like cell lesions
    Alessandro Vanoli
    Department of Pathology, University of Pavia and Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, 27100 Pavia, Italy
    Hum Pathol 44:1827-37. 2013
    ..Both enterochromaffin-like cell dysplasia and severe hyperplasia indicate increased risk of neuroendocrine tumor development in type A chronic atrophic gastritis with hypergastrinemia/G-cell hyperplasia. ..
  28. ncbi request reprint Microallelotyping defines the monoclonal or the polyclonal origin of mixed and collision endocrine-exocrine tumors of the gut
    Daniela Furlan
    Department of Clinical and Biological Sciences, University of Insubria, Varese, Italy
    Lab Invest 83:963-71. 2003
    ....
  29. doi request reprint Achaete-scute homolog 1 as a marker of poorly differentiated neuroendocrine carcinomas of different sites: a validation study using immunohistochemistry and quantitative real-time polymerase chain reaction on 335 cases
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, 21100 Varese, Italy
    Hum Pathol 44:1391-9. 2013
    ..However, achaete-scute homolog 1 may be proposed as a diagnostic marker of poor differentiation and may help to differentiate neuroendocrine carcinomas from neuroendocrine tumors in difficult cases...
  30. doi request reprint Colorectal poorly differentiated neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas: insights into the diagnostic immunophenotype, assessment of methylation profile, and search for prognostic markers
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    Am J Surg Pathol 36:601-11. 2012
    ....
  31. doi request reprint Lipid-rich variant of appendiceal well-differentiated endocrine tumor (carcinoid)
    Stefano La Rosa
    Servizio di Anatomia Patologica, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy
    Am J Clin Pathol 133:809-14. 2010
    ....
  32. doi request reprint Histologic characterization and improved prognostic evaluation of 209 gastric neuroendocrine neoplasms
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, 21100 Varese, Italy
    Hum Pathol 42:1373-84. 2011
    ..Such improved diagnostic and prognostic criteria for gastric neuroendocrine neoplasms are proposed and discussed...
  33. doi request reprint Mixed pituitary adenoma/craniopharyngioma: clinical, morphological, immunohistochemical and ultrastructural study of a case, review of the literature, and pathogenetic and nosological considerations
    Giovanna Finzi
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100, Varese, Italy
    Pituitary 17:53-9. 2014
    ..The patient completely recovered and, 10 months after surgery, head MR confirmed the complete resection of the lesion...
  34. doi request reprint Cushing's syndrome due to a pancreatic neuroendocrine tumor metastatic to the ovaries: a clinicopathological description of a case
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100, Varese, Italy
    Endocr Pathol 22:118-24. 2011
    ..The clinical situation worsened and the patient died in November 2009. The clinical aspects and the problems in the differential diagnosis are discussed...
  35. doi request reprint Neuroendocrine breast cancer: retrospective analysis of 96 patients and review of literature
    Francesca Rovera
    Department of General Surgery, University of Insubria, Varese, Italy
    Int J Surg 11:S79-83. 2013
    ..The aim of this retrospective study is to analyze the clinicopathological aspects of 96 NEBC patients who had undergone surgical resection at a single institute...
  36. ncbi request reprint Cytomegalovirus infection of endocrine system in a patient with diffuse large B-cell lymphoma. Report of a case
    Anastasios Stathis
    Department of Oncolog, Ospedale di Circolo and University of Insubria, Varese, Italy
    Tumori 95:119-22. 2009
    ....
  37. ncbi request reprint Clinico-pathological features of a series of 11 oncocytic endocrine tumours of the pancreas
    Marco Volante
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126, Turin, and Department of Pathology, Ospedale di Circolo, Varese, Italy
    Virchows Arch 448:545-51. 2006
    ....
  38. doi request reprint BACE2 is stored in secretory granules of mouse and rat pancreatic beta cells
    Giovanna Finzi
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    Ultrastruct Pathol 32:246-51. 2008
    ..The presence of BACE2 in secretory granules of beta cells suggests that it may play a role in diabetes-associated amyloidogenesis...
  39. pmc Solitary fibrous tumor of the male breast: a case report and review of the literature
    Francesca Rovera
    Department of Surgical Sciences, Ospedale di Circolo, Varese, Italy
    World J Surg Oncol 6:16. 2008
    ..Problems related to differential diagnosis and the possible pitfalls that can be encountered in the diagnostic iter of such rare tumor are discussed...
  40. ncbi request reprint Type or extension of intestinal metaplasia and immature/atypical "indefinite-for-dysplasia" lesions as predictors of gastric neoplasia
    Francesca Tava
    Department of Pathology, University of Pavia and IRCCS Policlinico San Matteo, Pavia, Italy
    Hum Pathol 37:1489-97. 2006
    ....
  41. doi request reprint Ectopic duodenal insulinoma: a very rare and challenging tumor type. Description of a case and review of the literature
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100, Varese, Italy
    Endocr Pathol 24:213-9. 2013
    ..The Ki67 proliferative index was 1 %. We have also reviewed the literature on this topic to give the reader a comprehensive overview of this very rare tumor type. ..
  42. ncbi request reprint Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues
    Guido Rindi
    Department of Pathology, University of Brescia, Italy
    Histochem Cell Biol 117:511-9. 2002
    ..In man ghrelin cells develop during early fetal life...
  43. doi request reprint IgG4-related disease of the ureter: report of two cases and review of the literature
    Alessandro Marando
    Department of Surgical and Morphological Sciences, University of Insubria, Viale Borri 57, 21100 Varese, Italy
    Virchows Arch 462:673-8. 2013
    ..We suggest using the name "ureteral IgG4-RD" for those lesions showing the same morphological features as IgG4-RDs located elsewhere...
  44. ncbi request reprint Malignant ectomesenchymoma of the nasal cavity
    Massimiliano Cergnul
    Department of Oncology, Ospedale di Circolo, Varese, Italy
    Lancet Oncol 8:358-60. 2007
  45. doi request reprint Poorly differentiated neuroendocrine carcinomas of the pancreas: a clinicopathologic analysis of 44 cases
    Olca Basturk
    Departments of Pathology Surgery Oncology, Memorial Sloan Kettering Cancer Center, New York, NY Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center Department of Surgery, Johns Hopkins University, Baltimore, MD Department of Pathology, Emory University, Atlanta, GA Department of Pathology, Penn State Hershey MC, Hershey Department of Pathology, University of Pittsburgh, Pittsburgh, PA Department of Pathology, Ohio State University, Columbus Department of Pathology, Cleveland Clinic, Cleveland, OH Department of Pathology, Mayo Clinic, Rochester, MN Department of Pathology, University of Michigan, Ann Arbor, MI Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA Department of Pathology, Indiana University, Indianapolis, IN Department of Pathology, Vanderbilt University, Nashville, TN Department of Pathology, Massachusetts General Hospital, Boston, MA Department of Pathology, Ospedale di Circolo, Varese, Italy Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, France
    Am J Surg Pathol 38:437-47. 2014
    ..In the pancreas, poorly differentiated neuroendocrine carcinomas include small cell carcinoma and large cell neuroendocrine carcinoma and are rare; data regarding their pathologic and clinical features are very limited...
  46. doi request reprint Metastasis at a tracheostomy site as the presenting sign of late recurrent breast cancer
    Nicola Rotolo
    Center for Thoracic Surgery, University of Insubria, Ospedale di Circolo, Varese, Italy
    Head Neck 35:E359-62. 2013
    ..Metastasis in a tracheostomy site occurs rarely, usually from head and neck primary tumors. Breast cancer relapse to a tracheostomy has not been described to date...