Stefano La Rosa

Summary

Affiliation: Ospedale di Circolo
Country: Italy

Publications

  1. ncbi The applications of FISH in tumor pathology
    M G Tibiletti
    Department of Pathology, Ospedale di Circolo University of Insubria, Varese, Italy
    Adv Clin Path 3:111-8. 1999
  2. ncbi Ultrastructural evidence of Tropheryma whippelii in PAS-negative granulomatous lymph nodes
    Giovanna Finzi
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    Ultrastruct Pathol 31:169-72. 2007
  3. ncbi Characterization of c-kit (CD117) expression in human normal pituitary cells and pituitary adenomas
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, Varese, Italy
    Endocr Pathol 19:104-11. 2008
  4. ncbi Improved histologic and clinicopathologic criteria for prognostic evaluation of pancreatic endocrine tumors
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, 21100 Varese, Italy
    Hum Pathol 40:30-40. 2009
  5. ncbi The monoclonal anti-BCL10 antibody (clone 331.1) is a sensitive and specific marker of pancreatic acinar cell carcinoma and pancreatic metaplasia
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100, Varese, Italy
    Virchows Arch 454:133-42. 2009
  6. ncbi Primary small cell neuroendocrine carcinoma of the kidney: morphological, immunohistochemical, ultrastructural, and cytogenetic study of a case and review of the literature
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100, Varese, Italy
    Endocr Pathol 20:24-34. 2009
  7. ncbi Thyroid metastases from typical carcinoid of the lung differentiating between medullary thyroid carcinoma and neuroendocrine tumor metastasis to the thyroid
    Stefano La Rosa
    Department of Pathology, Circle Hospital, Viale Borri 57, Varese, Italy
    Thyroid 19:521-6. 2009
  8. ncbi Ghrelin-producing well-differentiated neuroendocrine tumor (carcinoid) of tailgut cyst. Morphological, immunohistochemical, ultrastructural, and RT-PCR study of a case and review of the literature
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy
    Endocr Pathol 21:190-8. 2010
  9. ncbi Localization of carboxyl ester lipase in human pituitary gland and pituitary adenomas
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    J Histochem Cytochem 58:881-9. 2010
  10. ncbi TTF1 expression in normal lung neuroendocrine cells and related tumors: immunohistochemical study comparing two different monoclonal antibodies
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, 21100 Varese, Italy
    Virchows Arch 457:497-507. 2010

Detail Information

Publications37

  1. ncbi The applications of FISH in tumor pathology
    M G Tibiletti
    Department of Pathology, Ospedale di Circolo University of Insubria, Varese, Italy
    Adv Clin Path 3:111-8. 1999
    ..The interphasic FISH may be extremely informative in tumor pathology even if the results are dependent on a good technical quality and adequate controls...
  2. ncbi Ultrastructural evidence of Tropheryma whippelii in PAS-negative granulomatous lymph nodes
    Giovanna Finzi
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    Ultrastruct Pathol 31:169-72. 2007
    ..This case confirms the role of the electron microscopy in the diagnosis of Whipple disease, especially for extra-intestinal lesions and at the initial phase of the disease, when the characteristic PAS-positive macrophages can be absent...
  3. ncbi Characterization of c-kit (CD117) expression in human normal pituitary cells and pituitary adenomas
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, Varese, Italy
    Endocr Pathol 19:104-11. 2008
    ..By contrast, all ten prolactin cell and seven growth hormone cell adenomas were c-kit negative. These data suggest that, in normal conditions, c-kit may be involved in the pituitary-adrenal axis regulation...
  4. ncbi Improved histologic and clinicopathologic criteria for prognostic evaluation of pancreatic endocrine tumors
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, 21100 Varese, Italy
    Hum Pathol 40:30-40. 2009
    ..The TNM system proved to be highly predictive of patient outcome and easy to combine with histologic and clinicopathologic parameters to classify pancreatic endocrine tumors into groups of increasing malignant potential...
  5. ncbi The monoclonal anti-BCL10 antibody (clone 331.1) is a sensitive and specific marker of pancreatic acinar cell carcinoma and pancreatic metaplasia
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100, Varese, Italy
    Virchows Arch 454:133-42. 2009
    ..We suggest using BCL10 antibody for diagnosing pancreatic tumors and whenever an acinar differentiation is suspected in gastrointestinal neoplastic and metaplastic lesions...
  6. ncbi Primary small cell neuroendocrine carcinoma of the kidney: morphological, immunohistochemical, ultrastructural, and cytogenetic study of a case and review of the literature
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100, Varese, Italy
    Endocr Pathol 20:24-34. 2009
    ....
  7. ncbi Thyroid metastases from typical carcinoid of the lung differentiating between medullary thyroid carcinoma and neuroendocrine tumor metastasis to the thyroid
    Stefano La Rosa
    Department of Pathology, Circle Hospital, Viale Borri 57, Varese, Italy
    Thyroid 19:521-6. 2009
    ..The most problematic differential diagnosis is with medullary thyroid carcinoma (MTC), a well-differentiated neuroendocrine tumor showing cytological and histological features similar to those of a lung carcinoid...
  8. ncbi Ghrelin-producing well-differentiated neuroendocrine tumor (carcinoid) of tailgut cyst. Morphological, immunohistochemical, ultrastructural, and RT-PCR study of a case and review of the literature
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy
    Endocr Pathol 21:190-8. 2010
    ..In addition, we have accurately reviewed the literature on presacral carcinoids, associated or unassociated with tailgut cysts, to give the reader a comprehensive overview of these very rare tumor types...
  9. ncbi Localization of carboxyl ester lipase in human pituitary gland and pituitary adenomas
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    J Histochem Cytochem 58:881-9. 2010
    ....
  10. ncbi TTF1 expression in normal lung neuroendocrine cells and related tumors: immunohistochemical study comparing two different monoclonal antibodies
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, 21100 Varese, Italy
    Virchows Arch 457:497-507. 2010
    ..In addition, the expression of TTF1 in normal NE cells suggests a possible role for the transcription factor in their development and differentiation...
  11. ncbi Prognostic and biological significance of cytokeratin 19 in pancreatic endocrine tumours
    S La Rosa
    Department of Pathology, Ospedale di Circolo, University of Insubria, Varese, Italy
    Histopathology 50:597-606. 2007
    ..The aim of this study was to evaluate the prognostic value of CK19 expression in PETs...
  12. ncbi Morphological and ultrastructural features of human islet grafts performed in diabetic nude mice
    Giovanna Finzi
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    Ultrastruct Pathol 29:525-33. 2005
    ..The authors conclude that islet graft failure may be due to an insufficient beta cell mass related to their distress probably caused by anoxia and/or overstimulation...
  13. ncbi Involvement of 1p36 region in two cases of adenocarcinoma of the ampulla of Vater
    Barbara Bernasconi
    Department of Pathology, Ospedale di Circolo, University of Insubria, Varese, Italy
    Cancer Genet Cytogenet 138:133-8. 2002
    ..In these tumors, the 1p36 region may play a relevant role in the progression towards a high grade of anaplasia...
  14. ncbi Localization of myosin XVA in endocrine tumors of gut and pancreas
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    Endocr Pathol 13:29-37. 2002
    ..Although the role of this protein in endocrine cells is unknown, previous studies suggest that it may have a role in secretory granule movement and/or hormone secretion...
  15. ncbi CDX2 as a marker of intestinal EC-cells and related well-differentiated endocrine tumors
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo and University of Insubria, Varese, Italy
    Virchows Arch 445:248-54. 2004
    ..We conclude that CDX2 may be considered a sensitive and specific marker of midgut EC-cells and EC-cell tumors, and its expression may be useful in the diagnosis of metastases from occult ETs...
  16. ncbi Clinicopathologic study of 62 acinar cell carcinomas of the pancreas: insights into the morphology and immunophenotype and search for prognostic markers
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, 21100 Varese, Italy
    Am J Surg Pathol 36:1782-95. 2012
    ..In addition, vascular and perineural invasion and CK19 and p53 expression showed a trend for poor prognosis, not reaching statistical significance...
  17. ncbi Different molecular profiles characterize well-differentiated endocrine tumors and poorly differentiated endocrine carcinomas of the gastroenteropancreatic tract
    Daniela Furlan
    Department of Human Morphology, University of Insubria and Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy
    Clin Cancer Res 10:947-57. 2004
    ..Although no specific molecular markers of malignancy can be defined with certainty, the ploidy status and the degree of chromosomal derangements appear to be the most informative genetic factors with prognostic significance...
  18. ncbi Ghrelin expression in gut endocrine growths
    Guido Rindi
    Department of Pathology, University of Brescia, Italy
    Histochem Cell Biol 117:521-5. 2002
    ..We conclude that ghrelin cells may take part in gut endocrine growths, with special reference to well-differentiated endocrine tumours of the stomach, independently from associated signs of endocrine hyperfunction...
  19. ncbi Localization of inhibins and activins in normal endocrine cells and endocrine tumors of the gut and pancreas: an immunohistochemical and in situ hybridization study
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo
    J Histochem Cytochem 52:217-25. 2004
    ....
  20. ncbi Serotonin-producing enterochromaffin cell tumors of the pancreas: clinicopathologic study of 15 cases and comparison with intestinal enterochromaffin cell tumors
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    Pancreas 40:883-95. 2011
    ..This study analyzes the clinicopathologic features of a series of pancreatic EC cell neoplasms and their similarities to and differences from intestinal EC cell tumors...
  21. ncbi Neuroendocrine carcinomas of the breast
    Francesca Rovera
    Department of Surgical Sciences, University of Insubria, Varese, Italy
    Int J Surg 6:S113-5. 2008
    ..They are rare lesions representing about 2-3% of all breast cancers and affecting more frequently elderly patients...
  22. ncbi Ghrelin expression and actions: a novel peptide for an old cell type of the diffuse endocrine system
    Guido Rindi
    Department of Pathology, University of Parma, Italy
    Exp Biol Med (Maywood) 229:1007-16. 2004
    ..This review aims to summarize recent data on ghrelin cell distribution in the diffuse endocrine system and discuss local and general ghrelin function during development, adulthood, and endocrine tumor development...
  23. ncbi Colonic carcinoma with a pancreatic acinar cell differentiation. A case report
    Anna Maria Chiaravalli
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100, Varese, Italy
    Virchows Arch 455:527-31. 2009
    ..There was no evidence of a pancreatic acinar cell carcinoma or of heterotopic pancreatic tissue. A colonic origin ought to be suspected when a metastatic carcinoma of unknown primary shows an acinar differentiation...
  24. ncbi Localization of vascular endothelial growth factor and its receptors in digestive endocrine tumors: correlation with microvessel density and clinicopathologic features
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    Hum Pathol 34:18-27. 2003
    ....
  25. ncbi Microallelotyping defines the monoclonal or the polyclonal origin of mixed and collision endocrine-exocrine tumors of the gut
    Daniela Furlan
    Department of Clinical and Biological Sciences, University of Insubria, Varese, Italy
    Lab Invest 83:963-71. 2003
    ....
  26. ncbi Colorectal poorly differentiated neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas: insights into the diagnostic immunophenotype, assessment of methylation profile, and search for prognostic markers
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    Am J Surg Pathol 36:601-11. 2012
    ....
  27. ncbi Histologic characterization and improved prognostic evaluation of 209 gastric neuroendocrine neoplasms
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, 21100 Varese, Italy
    Hum Pathol 42:1373-84. 2011
    ..Such improved diagnostic and prognostic criteria for gastric neuroendocrine neoplasms are proposed and discussed...
  28. ncbi Lipid-rich variant of appendiceal well-differentiated endocrine tumor (carcinoid)
    Stefano La Rosa
    Servizio di Anatomia Patologica, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy
    Am J Clin Pathol 133:809-14. 2010
    ....
  29. ncbi Diagnostic utility of MS-MLPA in DNA methylation profiling of adenocarcinomas and neuroendocrine carcinomas of the colon-rectum
    Daniela Furlan
    Department of Surgical and Morphological Sciences, Anatomic Pathology Unit, University of Insubria and Ospedale di Circolo, Via O Rossi, 9, 21100, Varese, Italy
    Virchows Arch 462:47-56. 2013
    ..Aberrant gene methylation is a common abnormality in CRC initiation and may be observed in tumors with very different genetic and clinicopathological profiles...
  30. ncbi Cushing's syndrome due to a pancreatic neuroendocrine tumor metastatic to the ovaries: a clinicopathological description of a case
    Stefano La Rosa
    Department of Pathology, Ospedale di Circolo, Viale Borri 57, 21100, Varese, Italy
    Endocr Pathol 22:118-24. 2011
    ..The clinical situation worsened and the patient died in November 2009. The clinical aspects and the problems in the differential diagnosis are discussed...
  31. ncbi Cytomegalovirus infection of endocrine system in a patient with diffuse large B-cell lymphoma. Report of a case
    Anastasios Stathis
    Department of Oncolog, Ospedale di Circolo and University of Insubria, Varese, Italy
    Tumori 95:119-22. 2009
    ....
  32. ncbi BACE2 is stored in secretory granules of mouse and rat pancreatic beta cells
    Giovanna Finzi
    Department of Pathology, Ospedale di Circolo, Varese, Italy
    Ultrastruct Pathol 32:246-51. 2008
    ..The presence of BACE2 in secretory granules of beta cells suggests that it may play a role in diabetes-associated amyloidogenesis...
  33. ncbi Solitary fibrous tumor of the male breast: a case report and review of the literature
    Francesca Rovera
    Department of Surgical Sciences, Ospedale di Circolo, Varese, Italy
    World J Surg Oncol 6:16. 2008
    ..Problems related to differential diagnosis and the possible pitfalls that can be encountered in the diagnostic iter of such rare tumor are discussed...
  34. ncbi Clinico-pathological features of a series of 11 oncocytic endocrine tumours of the pancreas
    Marco Volante
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126, Turin, and Department of Pathology, Ospedale di Circolo, Varese, Italy
    Virchows Arch 448:545-51. 2006
    ....
  35. ncbi Type or extension of intestinal metaplasia and immature/atypical "indefinite-for-dysplasia" lesions as predictors of gastric neoplasia
    Francesca Tava
    Department of Pathology, University of Pavia and IRCCS Policlinico San Matteo, Pavia, Italy
    Hum Pathol 37:1489-97. 2006
    ....
  36. ncbi Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues
    Guido Rindi
    Department of Pathology, University of Brescia, Italy
    Histochem Cell Biol 117:511-9. 2002
    ..In man ghrelin cells develop during early fetal life...
  37. ncbi Malignant ectomesenchymoma of the nasal cavity
    Massimiliano Cergnul
    Department of Oncology, Ospedale di Circolo, Varese, Italy
    Lancet Oncol 8:358-60. 2007