N Bizzaro

Summary

Affiliation: Ospedale Civile
Country: Italy

Publications

  1. ncbi Sensitivity and specificity of immunological methods for the detection of anti-topoisomerase I (Scl70) autoantibodies: results of a multicenter study. The Italian Society of Laboratory Medicine Study Group on the Diagnosis of Autoimmune diseases
    N Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, 30027 S Dona di Piave VE, Italy
    Clin Chem 46:1681-5. 2000
  2. ncbi Prevalence and clinical correlation of anti-phospholipid-binding protein antibodies in anticardiolipin-negative patients with systemic lupus erythematosus and women with unexplained recurrent miscarriages
    Nicola Bizzaro
    Laboratorio di Patologia Clinica, Ospedale di S Donà di Piave, Italy
    Arch Pathol Lab Med 129:61-8. 2005
  3. ncbi Appropriateness in anti-nuclear antibody testing: from clinical request to strategic laboratory practice
    N Bizzaro
    Laboratory of Clinical Pathology, Ospedale Civile, San Donà di Piave VE, Italy
    Clin Exp Rheumatol 22:349-55. 2004
  4. ncbi Association of celiac disease with connective tissue diseases and autoimmune diseases of the digestive tract
    Nicola Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, S Donà di Piave VE 30027, Italy
    Autoimmun Rev 2:358-63. 2003
  5. ncbi IgA and IgG tissue transglutaminase antibody prevalence and clinical significance in connective tissue diseases, inflammatory bowel disease, and primary biliary cirrhosis
    N Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, 30027 S Dona di Piave VE, Italy
    Dig Dis Sci 48:2360-5. 2003
  6. ncbi Autoantibody detection in scleroderma patients. Diagnostic and analytical performances of a new coupled particle light scattering immunoassay
    N Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, S Dona di Piave, Italy
    Clin Exp Rheumatol 20:45-51. 2002
  7. ncbi Diagnostic accuracy of the anti-citrulline antibody assay for rheumatoid arthritis
    N Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, 30027 S Dona di Piave VE, Italy
    Clin Chem 47:1089-93. 2001
  8. pmc New coupled-particle light-scattering assay for detection of Ro/SSA (52 and 60 kilodaltons) and La/SSB autoantibodies in connective tissue diseases
    N Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, Via N Sauro 25, 30027 S Donà di Piave, Italy
    Clin Diagn Lab Immunol 8:922-5. 2001
  9. ncbi Anti-prothrombin antibodies predict thrombosis in patients with systemic lupus erythematosus: a 15-year longitudinal study
    N Bizzaro
    Laboratory of Clinical Pathology, Hospital of Tolmezzo, Tolmezzo, Italy
    J Thromb Haemost 5:1158-64. 2007
  10. ncbi Low specificity of anti-tissue transglutaminase antibodies in patients with primary biliary cirrhosis
    N Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, Tolmezzo, Italy
    J Clin Lab Anal 20:184-9. 2006

Collaborators

Detail Information

Publications42

  1. ncbi Sensitivity and specificity of immunological methods for the detection of anti-topoisomerase I (Scl70) autoantibodies: results of a multicenter study. The Italian Society of Laboratory Medicine Study Group on the Diagnosis of Autoimmune diseases
    N Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, 30027 S Dona di Piave VE, Italy
    Clin Chem 46:1681-5. 2000
    ..We wished to quantify the performance of the currently available commercial systems for the assay of anti-topoisomerase I antibodies in a large multicenter study...
  2. ncbi Prevalence and clinical correlation of anti-phospholipid-binding protein antibodies in anticardiolipin-negative patients with systemic lupus erythematosus and women with unexplained recurrent miscarriages
    Nicola Bizzaro
    Laboratorio di Patologia Clinica, Ospedale di S Donà di Piave, Italy
    Arch Pathol Lab Med 129:61-8. 2005
    ..Anti-phospholipid antibodies (aPL) are a heterogeneous group of autoantibodies, the presence of which is associated with thrombotic events and miscarriage...
  3. ncbi Appropriateness in anti-nuclear antibody testing: from clinical request to strategic laboratory practice
    N Bizzaro
    Laboratory of Clinical Pathology, Ospedale Civile, San Donà di Piave VE, Italy
    Clin Exp Rheumatol 22:349-55. 2004
    ..Appropriateness is a complex task that can be achieved only by combining the efforts from the laboratory and the clinic, thereby using scientific knowledge, inter-disciplinary consultation and expert clinical investigation...
  4. ncbi Association of celiac disease with connective tissue diseases and autoimmune diseases of the digestive tract
    Nicola Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, S Donà di Piave VE 30027, Italy
    Autoimmun Rev 2:358-63. 2003
    ..In this short review we describe the association between CD and CTD, inflammatory bowel disease and primary biliary cirrhosis, with special emphasis on the diagnostic accuracy of CD antibody assays...
  5. ncbi IgA and IgG tissue transglutaminase antibody prevalence and clinical significance in connective tissue diseases, inflammatory bowel disease, and primary biliary cirrhosis
    N Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, 30027 S Dona di Piave VE, Italy
    Dig Dis Sci 48:2360-5. 2003
    ..4%). For these reasons, serological screening testing for CD is not recommended in CTD patients or in subjects affected with IBD or PBC, unless there is a relevant clinical suspicion of CD...
  6. ncbi Autoantibody detection in scleroderma patients. Diagnostic and analytical performances of a new coupled particle light scattering immunoassay
    N Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, S Dona di Piave, Italy
    Clin Exp Rheumatol 20:45-51. 2002
    ..We evaluated the diagnostic and analytical performance of the Coupled Particle Light Scattering technology applied to the detection of anti-topoisomerase I (anti-Scl70) and anti-CENP-B autoantibodies...
  7. ncbi Diagnostic accuracy of the anti-citrulline antibody assay for rheumatoid arthritis
    N Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, 30027 S Dona di Piave VE, Italy
    Clin Chem 47:1089-93. 2001
    ..We evaluated the diagnostic accuracy of a new commercial ELISA in detecting anti-cyclic citrullinated peptide (CCP) antibodies for the diagnosis of RA...
  8. pmc New coupled-particle light-scattering assay for detection of Ro/SSA (52 and 60 kilodaltons) and La/SSB autoantibodies in connective tissue diseases
    N Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, Via N Sauro 25, 30027 S Donà di Piave, Italy
    Clin Diagn Lab Immunol 8:922-5. 2001
    ..The results of the present study indicate that this new immunoassay is an efficient diagnostic tool for the detection of anti-Ro/SSA and anti-La/SSB antibodies in patients with autoimmune disorders...
  9. ncbi Anti-prothrombin antibodies predict thrombosis in patients with systemic lupus erythematosus: a 15-year longitudinal study
    N Bizzaro
    Laboratory of Clinical Pathology, Hospital of Tolmezzo, Tolmezzo, Italy
    J Thromb Haemost 5:1158-64. 2007
    ..To evaluate the role of anti-prothrombin (anti-PT) antibodies in predicting thrombosis in patients with systemic lupus erythematosus (SLE)...
  10. ncbi Low specificity of anti-tissue transglutaminase antibodies in patients with primary biliary cirrhosis
    N Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, Tolmezzo, Italy
    J Clin Lab Anal 20:184-9. 2006
    ..The results of this study showed that a true association between PBC and CD was present in only 2% of the patients and that, in most cases, the false positive results were attributable to the type of substrate utilized in the assay...
  11. ncbi A prospective study of 1038 pregnancies on the predictive value of anti-annexin V antibodies for fetal loss
    N Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, via Morgagni, 18, 33028 Tolmezzo UD, Italy
    Ann N Y Acad Sci 1050:348-56. 2005
    ....
  12. doi Cutting-edge issues in celiac disease and in gluten intolerance
    N Bizzaro
    Laboratory of Clinical Pathology, S Antonio Hospital, Tolmezzo, Italy
    Clin Rev Allergy Immunol 42:279-87. 2012
    ....
  13. doi Multicentric evaluation of a second generation assay to detect antiviral citrullinated peptide antibodies: a collaborative study by the Forum Interdisciplinare per la Ricerca nelle Malattie Autoimmuni
    N Bizzaro
    Laboratorio di Patologia Clinica, Ospedale S Antonio, Tolmezzo, Italy
    J Clin Pathol 64:1139-41. 2011
    ..A novel immunoenzymatic assay using viral citrullinated peptides derived from Epstein-Barr virus-encoded proteins (viral citrullinated peptide 2 (VCP2)) has been developed and evaluated by means of a multicentre collaborative study...
  14. ncbi The predictive significance of autoantibodies in organ-specific autoimmune diseases
    Nicola Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, via Morgagni, 18, 33028, Tolmezzo, Italy
    Clin Rev Allergy Immunol 34:326-31. 2008
    ....
  15. doi TSH receptor autoantibody immunoassay in patients with Graves' disease: improvement of diagnostic accuracy over different generations of methods. Systematic review and meta-analysis
    R Tozzoli
    Laboratory of Clinical Pathology, Dept of Laboratory Medicine, S Maria degli Angeli Hospital, Pordenone, Italy
    Autoimmun Rev 12:107-13. 2012
    ..The aim of our systematic review and meta-analysis is to verify the diagnostic performance of TRAb detected with 2nd and 3rd generation immunoassay methods...
  16. ncbi Are we at a stage to predict autoimmune rheumatic diseases?
    Nicola Bizzaro
    Ospedale Civile, Tolmezzo, Italy
    Arthritis Rheum 56:1736-44. 2007
  17. doi Diagnostic accuracy of immunoassays for the detection of antibodies to citrullinated proteins
    Nicola Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, via Morgagni, 18, 33028, Tolmezzo, UD, Italy
    Clin Rev Allergy Immunol 34:16-20. 2008
    ..This review will consider the most relevant characteristics of the ACPA-ELISA assays and will describe the results of a comparative study performed with all the currently available second- and third-generation commercial methods...
  18. ncbi Autoantibodies as predictors of disease: the clinical and experimental evidence
    Nicola Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, via Morgagni, 33028 Tolmezzo, Italy
    Autoimmun Rev 6:325-33. 2007
    ..This review examines the various autoantibodies for which a role in predicting the development of an autoimmune disease has been demonstrated in long-term prospective studies...
  19. ncbi Immunoassay of anti-thyroid autoantibodies: high analytical variability in second generation methods
    Renato Tozzoli
    Laboratorio Analisi Chimico Cliniche e Microbiologia, Ospedale Civile, Latisana, UD, Italy
    Clin Chem Lab Med 40:568-73. 2002
    ....
  20. ncbi Analytical and diagnostic characteristics of 11 2nd- and 3rd-generation immunoenzymatic methods for the detection of antibodies to citrullinated proteins
    Nicola Bizzaro
    Laboratory of Clinical Pathology, Hospital of Tolmezzo, Italy
    Clin Chem 53:1527-33. 2007
    ..Measurement of antibodies to citrullinated peptides or proteins (CP) is a new test for the diagnosis of rheumatoid arthritis (RA). We analyzed the analytical characteristics and diagnostic accuracy of commercially available methods...
  21. ncbi Antibodies to citrullinated peptides: a significant step forward in the early diagnosis of rheumatoid arthritis
    Nicola Bizzaro
    Laboratorio di Patologia Clinica, Ospedale Civile, Tolmezzo, Italy
    Clin Chem Lab Med 45:150-7. 2007
    ....
  22. doi Definition of reference limits for autoantibodies to thyroid peroxidase and thyroglobulin in a large population of outpatients using an indirect method based on current data
    Renato Tozzoli
    Laboratory of Clinical Pathology, Ospedale Civile, Latisana, Italy
    Arch Pathol Lab Med 132:1924-8. 2008
    ..The reference limits for thyroid antibodies are generally made by measuring thyroid peroxidase and thyroglobulin antibody values in a group of healthy subjects (direct method), as proposed by the National Academy of Clinical Biochemistry...
  23. ncbi Antibodies to the lens and cornea in anti-DFS70-positive subjects
    Nicola Bizzaro
    Laboratorio di Patologia Clinica, Ospedale di Tolmezzo, Italy
    Ann N Y Acad Sci 1107:174-83. 2007
    ..We have also seen that some DFS70-positive sera have antibodies that recognize antigens of the lens. Further studies are needed to investigate the fine specificity and the possible significance of these new autoantibodies...
  24. doi Diagnostic accuracy of four different immunological methods for the detection of anti-F-actin autoantibodies in type 1 autoimmune hepatitis and other liver-related disorders
    Danilo Villalta
    Allergologia e Immunologia Clinica, Pordenone, Italy
    Autoimmunity 41:105-10. 2008
    ..Smooth muscle antibodies (SMA) with anti-F-actin specificity are commonly regarded as specific markers of type 1 autoimmune hepatitis (AIH-1) but, at the moment, a gold standard method for their identification is not available...
  25. ncbi IgG anti-transglutaminase autoantibodies in systemic lupus erythematosus and Sjögren syndrome
    Danilo Villalta
    Clin Chem 48:1133. 2002
  26. ncbi The mosaic of autoimmunity: prediction, autoantibodies, and therapy in autoimmune diseases--2008
    Yehuda Shoenfeld
    Department of Medicine B and Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 10:13-9. 2008
  27. ncbi High prevalence of celiac disease in autoimmune hepatitis detected by anti-tissue tranglutaminase autoantibodies
    Danilo Villalta
    Immunologia Clinica e Virologia, A O S Maria degli Angeli, Pordenone, Italy
    J Clin Lab Anal 19:6-10. 2005
    ..9 per 1,000; 95% CI, 2.8-7.8). The results of this study showed a high prevalence of CD in patients with AIH. For this reason, early serological screening testing for CD is strongly recommended for all AIH patients...
  28. doi Cell lines that express membrane-associated DNA for anti-DNA antibody detection
    Elio Tonutti
    Immunopatologia e Allergologia, Azienda Ospedaliero Universitaria S Maria della Misericordia, Udine, Italy
    Clin Chem Lab Med 46:458-62. 2008
    ....
  29. ncbi Testing for IgG class antibodies in celiac disease patients with selective IgA deficiency. A comparison of the diagnostic accuracy of 9 IgG anti-tissue transglutaminase, 1 IgG anti-gliadin and 1 IgG anti-deaminated gliadin peptide antibody assays
    Danilo Villalta
    Immunologia Clinica e Virologia, AO S Maria degli Angeli, Via Montereale 24, Pordenone, Italy
    Clin Chim Acta 382:95-9. 2007
    ....
  30. ncbi Guidelines for the laboratory use of autoantibody tests in the diagnosis and monitoring of autoimmune rheumatic diseases
    Renato Tozzoli
    Department of Laboratory Medicine, Civic Hospital, Latisana, Italy
    Am J Clin Pathol 117:316-24. 2002
    ..To improve analytic performances and help select the most appropriate test for specific autoantibodies, as well as provide education and guidance in the use of these tests, special emphasis is placed on laboratory methods...
  31. ncbi False positive reactions for IgA and IgG anti-tissue transglutaminase antibodies in liver cirrhosis are common and method-dependent
    Danilo Villalta
    Immunologia Clinica e Virologia, Azienda Ospedaliera, S Maria degli Angeli, Via Montereale 24, 33170 Pordenone, Italy
    Clin Chim Acta 356:102-9. 2005
    ..In order to establish whether this was attributable to methodological differences, anti-tTG antibodies were assayed in a large number of patients suffering from liver cirrhosis (LC)...
  32. ncbi The relevance of autoantigen source and cutoff definition in antichromatin (nucleosome) antibody immunoassays
    Danilo Villalta
    Immunologia Clinica e Virologia, Azienda Ospedaliera S Maria degli Angeli, Via Montereale 24, 33170 Pordenone, Italy
    Ann N Y Acad Sci 1050:176-84. 2005
    ....
  33. ncbi Comparison of ANA endpoint dilution using the PolyTiter immunofluorescent titration system and conventional serial dilution
    Nicola Bizzaro
    Laboratory of Clinical Pathology, Ospedale Civile, S Dona di Piave, Venice, Italy
    J Clin Lab Anal 16:91-4. 2002
    ..homogeneous). The PolyTiter system demonstrated satisfactory performance in comparison to the current standard for determining ANA dilution endpoints, while significantly reducing operator labor, time, and materials usage...
  34. ncbi Immunocytochemistry for the heavy chain of the non-muscle myosin IIA as a diagnostic tool for MYH9-related disorders
    Alessandro Pecci
    Department of Internal Medicine, IRCCS San Matteo, University of Pavia, Italy
    Br J Haematol 117:164-7. 2002
    ..Therefore, immunocytochemistry for NMMHC-A is a simple and sensitive method to detect pathological phenotypes of granulocytes and platelets in the diagnosis of MYH9-related disorders...
  35. ncbi Biological and clinical relevance of anti-prothrombin antibodies
    Anna Ghirardello
    Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Ann N Y Acad Sci 1109:503-10. 2007
    ....
  36. ncbi The laboratory approach to the diagnosis of autoimmune diseases: is it time to change?
    Danilo Villalta
    Immunologia Clinica e Virologia, Azienda Ospedaliera S Maria degli Angeli, Via Montereale 24, 33170 Pordenone, Italy
    Autoimmun Rev 6:359-65. 2007
    ....
  37. ncbi Interpretative comments on autoantibody tests
    Elio Tonutti
    Laboratorio di Immunopatologia e Allergologia, Azienda Ospedaliera S Maria della Misericordia, P zzale S Maria della Misericordia, 33100 Udine, Italy
    Autoimmun Rev 6:341-6. 2007
    ....
  38. ncbi Diagnostic accuracy of ELISA methods as an alternative screening test to indirect immunofluorescence for the detection of antinuclear antibodies. Evaluation of five commercial kits
    Elio Tonuttia
    Laboratorio Analisi Cliniche, Ospedale S Maria della Misericordia, Udine, Italy
    Autoimmunity 37:171-6. 2004
    ..However, others do not ensure acceptable results. Therefore, careful evaluation of the various kits on the market is advisable before including any of these methods in the clinical and diagnostic testing...
  39. ncbi Low sensitivity of anti-alpha-fodrin antibodies in patients with primary Sjögren's syndrome
    Nicola Bizzaro
    J Rheumatol 31:2310-1; author reply 2311. 2004
  40. ncbi Analytical and diagnostic accuracy of the EliA automated enzyme fluoroimmunoassay for antineutrophil cytoplasmic autoantibody detection
    Danilo Villalta
    Immunologia Clinica e Virologia, Azienda Ospedaliera Santa Maria degli Angeli, Via Montereale 24, 33170 Pordenone, Italy
    Clin Chem Lab Med 42:1161-7. 2004
    ....
  41. ncbi Autoantibody profiling of patients with autoimmune thyroid disease using a new multiplexed immunoassay method
    Renato Tozzoli
    Laboratorio di Chimica Clinica e Microbiologia, Ospedale di Latisana, Latisana, Italy
    Clin Chem Lab Med 44:837-42. 2006
    ..It has been proposed that only anti-thyroid-peroxidase (TPOAb) and not anti-thyroglobulin (TgAb) antibodies should be assayed in the diagnosis of autoimmune thyroid disease (AITD)...
  42. ncbi A latitudinal gradient study of common anti-infectious agent antibody prevalence in Italy and Colombia
    Vitor Pordeus
    Pro Cardiaco Hospital Research and Training Center PROCEP, Rio de Janeiro, Brazil
    Isr Med Assoc J 10:65-8. 2008
    ..A negative relationship between latitude and infectious disease species richness has been suggested...