Research Topics
Species | Catherine OakmanSummaryCountry: Italy Publications
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Publications
Recent advances in systemic therapy: new diagnostics and biological predictors of outcome in early breast cancerCatherine Oakman
Sandro Pitigliani Medical Oncology Unit, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
Breast Cancer Res 11:205. 2009..Extensive research continues on predictive gene identification for specific chemotherapeutic agents, particularly the anthracyclines, taxanes and alkylating agents...
The role of topoisomerase IIalpha and HER-2 in predicting sensitivity to anthracyclines in breast cancer patientsCatherine Oakman
Translational Research Unit, Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Piazza Ospedale 2, 59100 Prato, Italy
Cancer Treat Rev 35:662-7. 2009....
Predicting anthracycline benefit: have we made any progress?Erica Moretti
Sandro Pitigliani Medical Oncology Unit, Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
Curr Opin Oncol 21:507-15. 2009..Identification of the individuals to derive this benefit may be guided by predictive biomarkers. This review focuses on the search for biomarkers, particularly focusing on the potential roles for HER-2 and/or topoisomerase IIalpha...
Adjuvant systemic treatment for individual patients with triple negative breast cancerCatherine Oakman
Sandro Pitigliani Medical Oncology Unit, Department of Oncology, Hospital ofPrato, Istituto Toscano Tumori, Piazza Ospedale 2, 59100 Prato, Italy
Breast 20:S135-41. 2011..This review will focus on systemic chemotherapy in early TNBC, particularly anthracyclines and platinums, and potential predictive tools to guide chemotherapy use...
Inter- and intra-tumoral heterogeneity in DNA damage evaluated by comet assay in early breast cancer patientsFrancesca Galardi
Translational Research Unit, Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
Breast 21:336-42. 2012..Comet assay warrants further study as a potential clinical tool for identification of tumoral DNA damage and ultimately, individualised use of DNA damaging therapy...
Breast cancer assessment tools and optimizing adjuvant therapyCatherine Oakman
Sandro Pitigliani Medical Oncology Unit, Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Piazza Ospedale 2, 59100 Prato, Italy
Nat Rev Clin Oncol 7:725-32. 2010..The presence of drug targets and targetable signaling pathways, rather than molecularly defined subgroups, may ultimately drive treatment decisions...
Management of triple negative breast cancerCatherine Oakman
Sandro Pitigliani Medical Oncology Unit, Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Piazza Ospedale 2, Prato, Italy
Breast 19:312-21. 2010..Critical to optimal future management are accurate identification of truly triple negative disease and adequately powered prospective TNBC trials to establish treatment efficacy and define predictive biomarkers...
Fulvestrant in the management of postmenopausal women with advanced, endocrine-responsive breast cancerCatherine Oakman
Sandro Pitigliani Medical Oncology Unit, Hospital of Prato, Istituto Toscano Tumori, Piazza Ospedale 2, Prato, Italy
Future Oncol 7:173-86. 2011..A key issue is identification of patients with ER-positive disease who retain sensitivity to antiestrogen therapy after progression on tamoxifen and/or aromatase inhibitors...
Adjuvant chemotherapy--the dark side of clinical trials. Have we learnt more?Catherine Oakman
Sandro Pitigliani Medical Oncology Unit, Department of Oncology, Hospital of Prato, Tuscany Cancer Institute, Prato, Italy
Breast 18:S18-24. 2009..The basal phenotype may be predictive of benefit from DNA damaging agents...
Management of elderly patients with breast cancer: updated recommendations of the International Society of Geriatric Oncology (SIOG) and European Society of Breast Cancer Specialists (EUSOMA)Laura Biganzoli
Sandro Pitigliani Medical Oncology Unit, Istituto Toscano Tumori, Hospital of Prato, Prato, Italy
Lancet Oncol 13:e148-60. 2012..Recommendations were updated for screening, primary endocrine therapy, surgery, radiotherapy, neoadjuvant and adjuvant systemic therapy, and metastatic breast cancer...
Uncovering the metabolomic fingerprint of breast cancerCatherine Oakman
Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
Int J Biochem Cell Biol 43:1010-20. 2011..The dominant metabolic pathways and metabolite disturbances associated with malignant transformation of breast cells will be outlined, leading to an overview of potential clinical implications for individuals with breast cancer...
Role of lapatinib in the first-line treatment of patients with metastatic breast cancerCatherine Oakman
Sandro Pitigliani Medical Oncology Unit, Hospital of Prato, Istituto Toscano Tumori, Piazza Ospedale 2, 59100, Prato, Italy
Cancer Manag Res 2:13-25. 2010..The role of lapatinib in HER2-negative disease is unclear...
