G Novelli

Summary

Country: Italy

Publications

  1. ncbi request reprint A 3-year experience with Molecular Adsorbent Recirculating System (MARS): our results on 63 patients with hepatic failure and color Doppler US evaluation of cerebral perfusion
    Gilnardo Novelli
    Department of Surgery, University of Rome, Viale Regina Elena, Rome, Italy
    Liver Int 23:10-5. 2003
  2. doi request reprint Pediatric acute liver failure with molecular adsorbent recirculating system treatment
    G Novelli
    Dipartimento Paride Stefanini Unità di Chirurgia Generale e Trapianti d Organo, La Sapienza Universita di Roma, Rome, Italy
    Transplant Proc 40:1921-4. 2008
  3. doi request reprint Combined liver-kidney transplantation in polycystic disease: case reports
    M Rossi
    Chirurgia Generale E Trapianti d Organo, La Sapienza Universita di Roma, Umberto I Policlinico di Roma, Rome, Italy
    Transplant Proc 40:2075-6. 2008
  4. ncbi request reprint [Adacolumn apheresis for hepatitis C virus in patients waiting for kidney transplant. Preliminary study]
    Gilnardo Novelli
    Dipartimento P Stefanini Chirurgia Generale e Trapianti d Organo, La Sapienza Universita di Roma, Roma, Italy
    G Ital Nefrol 29:S109-13. 2012
  5. ncbi request reprint Adacolumn treatment in kidney transplant patients with hepatitis C virus
    G Novelli
    Dipartimento P Stefanini Chirurgia Generale e Trapianti d Organo, La Sapienza Universita di Roma, Rome, Italy
    Transplant Proc 41:1195-200. 2009
  6. ncbi request reprint Cytokine level modifications: molecular adsorbent recirculating system versus standard medical therapy
    G Novelli
    Dipartimento P Stefanini Chirurgia Generale e Trapianti d Organo, La Sapienza Universita di Roma, Rome, Italy
    Transplant Proc 41:1243-8. 2009
  7. ncbi request reprint Molecular adsorbents recirculating system treatment in acute-on-chronic hepatitis patients on the transplant waiting list improves model for end-stage liver disease scores
    G Novelli
    Dipartimento di Chirurgia Generale specialità chirurgiche e trapianti d organo P Stefanini, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Transplant Proc 39:1864-7. 2007
  8. ncbi request reprint Is legalizing the organ market possible?
    G Novelli
    Dipartimento di Chirurgia Generale specialità chirurgiche e trapianti d organo P Stefanini, Universita degli Studi di Roma La Sapienza, Viale del Policlinico N 188, Roma, Italy
    Transplant Proc 39:1743-5. 2007
  9. doi request reprint Early management of endotoxemia using the endotoxin activity assay and polymyxin B-based hemoperfusion
    G Novelli
    Dipartimento P Stefanini Chirurgia Generale e Trapianti d Organo, IT 00161 Rome, Italy
    Contrib Nephrol 167:91-101. 2010
  10. doi request reprint Clinical results of treatment of postsurgical endotoxin-mediated sepsis with polymyxin-B direct hemoperfusion
    G Novelli
    Dipartimento P Stefanini, Chirurgia Generale E Trapianti d Organo, La Sapienza Universita di Roma, Rome, Italy
    Transplant Proc 42:1021-4. 2010

Collaborators

Detail Information

Publications37

  1. ncbi request reprint A 3-year experience with Molecular Adsorbent Recirculating System (MARS): our results on 63 patients with hepatic failure and color Doppler US evaluation of cerebral perfusion
    Gilnardo Novelli
    Department of Surgery, University of Rome, Viale Regina Elena, Rome, Italy
    Liver Int 23:10-5. 2003
    ..In 16/20 patients, we could demonstrate a clear correlation between the improvement in clinical conditions (especially neurological status) and improvement in cerebral perfusion, measured by color Doppler US...
  2. doi request reprint Pediatric acute liver failure with molecular adsorbent recirculating system treatment
    G Novelli
    Dipartimento Paride Stefanini Unità di Chirurgia Generale e Trapianti d Organo, La Sapienza Universita di Roma, Rome, Italy
    Transplant Proc 40:1921-4. 2008
    ..Since 2004, the molecular adsorbent recirculating system (MARS) has been proposed as a bridging procedure. The aim of our study was to assess its efficacy in children with PALF...
  3. doi request reprint Combined liver-kidney transplantation in polycystic disease: case reports
    M Rossi
    Chirurgia Generale E Trapianti d Organo, La Sapienza Universita di Roma, Umberto I Policlinico di Roma, Rome, Italy
    Transplant Proc 40:2075-6. 2008
    ..Delaying transplantation results in a more difficult surgical technique, a higher rate of postoperative complications, and a disturbance of optimal graft retrieval because of the worse preoperative condition of the patients...
  4. ncbi request reprint [Adacolumn apheresis for hepatitis C virus in patients waiting for kidney transplant. Preliminary study]
    Gilnardo Novelli
    Dipartimento P Stefanini Chirurgia Generale e Trapianti d Organo, La Sapienza Universita di Roma, Roma, Italy
    G Ital Nefrol 29:S109-13. 2012
    ..Although this study investigated responses in a small number of patients, it was shown that the Adacolumn changed the cellular immunity and promoted early viral response...
  5. ncbi request reprint Adacolumn treatment in kidney transplant patients with hepatitis C virus
    G Novelli
    Dipartimento P Stefanini Chirurgia Generale e Trapianti d Organo, La Sapienza Universita di Roma, Rome, Italy
    Transplant Proc 41:1195-200. 2009
    ..Our aim was to reduce macrophages, granulocytes, monocytes, proinflammatory cells, and viremia levels using an extracorporeal device: Adacolumn Leukocyte Apheresis (Otzuka Electronics, Japan)...
  6. ncbi request reprint Cytokine level modifications: molecular adsorbent recirculating system versus standard medical therapy
    G Novelli
    Dipartimento P Stefanini Chirurgia Generale e Trapianti d Organo, La Sapienza Universita di Roma, Rome, Italy
    Transplant Proc 41:1243-8. 2009
    ..The subjects showed various disease etiologies but similar values for Model End-stage Liver Disease scores...
  7. ncbi request reprint Molecular adsorbents recirculating system treatment in acute-on-chronic hepatitis patients on the transplant waiting list improves model for end-stage liver disease scores
    G Novelli
    Dipartimento di Chirurgia Generale specialità chirurgiche e trapianti d organo P Stefanini, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Transplant Proc 39:1864-7. 2007
    ..MELD was adopted to determine the prognosis of patients with liver chronic desease. We evaluated the possibility to improve the MELD score of patients awaiting liver transplantation using a liver support device, namely, MARS...
  8. ncbi request reprint Is legalizing the organ market possible?
    G Novelli
    Dipartimento di Chirurgia Generale specialità chirurgiche e trapianti d organo P Stefanini, Universita degli Studi di Roma La Sapienza, Viale del Policlinico N 188, Roma, Italy
    Transplant Proc 39:1743-5. 2007
    ..Consequently, clandestine selling of organs is becoming more widespread for two main reasons: scientific progress and market demand. Our aim was to consider the protection of ethical principles through legislation...
  9. doi request reprint Early management of endotoxemia using the endotoxin activity assay and polymyxin B-based hemoperfusion
    G Novelli
    Dipartimento P Stefanini Chirurgia Generale e Trapianti d Organo, IT 00161 Rome, Italy
    Contrib Nephrol 167:91-101. 2010
    ..We evaluated the ability of the endotoxin activity (EA) assay to determine the need for early intervention for endotoxemia using polymyxin B-based hemoperfusion (PMX-DHP) on septic patients...
  10. doi request reprint Clinical results of treatment of postsurgical endotoxin-mediated sepsis with polymyxin-B direct hemoperfusion
    G Novelli
    Dipartimento P Stefanini, Chirurgia Generale E Trapianti d Organo, La Sapienza Universita di Roma, Rome, Italy
    Transplant Proc 42:1021-4. 2010
    ..Despite the small number of patients included in the study, the encouraging results suggest that PMX-DHP is a useful therapeutic strategy for lowering sepsis-related mortality...
  11. doi request reprint Predictive parameters after molecular absorbent recirculating system treatment integrated with model for end stage liver disease model in patients with acute-on-chronic liver failure
    G Novelli
    Dipartimento P Stefanini Chirurgia Generale e Trapianti d Organo, La Sapienza Universita di Roma, Rome, Italy
    Transplant Proc 42:1182-7. 2010
    ..Two homogenous groups were studied: one treated with standard medical therapy (SMT) and the other, with MARS...
  12. ncbi request reprint One hundred sixteen cases of acute liver failure treated with MARS
    G Novelli
    Policlinico Umberto I, University of Rome La Sapienza, Rome, Italy
    Transplant Proc 37:2557-9. 2005
    ..In patients with PDF, it is used for a waiting recovery of the transplanted organ. Therefore MARS can also limit the necessity to perform further transplants...
  13. doi request reprint Management of sepsis during MARS treatment in acute on chronic liver failure
    G Novelli
    Dipartimento P Stefanini, Chirurgia Generale E Trapianti d Organo, Sapienza Universita di Roma, Rome, Italy
    Transplant Proc 43:1085-90. 2011
    ....
  14. doi request reprint Primary nonfunction: timing retransplantation versus hemodynamic parameters and kidney function
    G Novelli
    Dipartimento Paride Stefanini Unità di Chirurgia Generale e Trapianti d Organo, La Sapienza Universita di Roma, Rome, Italy
    Transplant Proc 40:1854-7. 2008
    ..We evaluated potential changes in systemic hemodynamics and improved kidney function induced by the molecular adsorbent recirculating system (MARS) in a group of patients with primary nonfunction (PNF)...
  15. ncbi request reprint Clinical effects of direct hemoperfusion using a polymyxin-B immobilized column in solid organ transplanted patients with signs of severe sepsis and septic shock. A pilot study
    F Ruberto
    Department of Anesthesiology, Critical Care Medicine and Pain Therapy, Sapienza University of Rome, Rome, Italy
    Int J Artif Organs 30:915-22. 2007
    ..The aim of this study was to clarify the efficacy, safety and clinical effects of direct hemoperfusion with an immobilized polymyxin-B fiber column (DHP-PMX) in solid organ transplanted patients with severe sepsis or septic shock...
  16. doi request reprint Safety of polymyxin-B-based hemoperfusion in kidney and liver transplant recipients
    G Novelli
    Department P Stefanini General Surgery and Organs Transplant, Sapienza University, Rome, Italy
    Transplant Proc 44:1966-72. 2012
    ..We think it might be useful to determine EA routinely in transplant patients and look forward to large multicenter clinical trials to accurately assess the benefits of the EAA plus DHP-PMX to treat transplant patients with sepsis...
  17. doi request reprint Simultaneous pancreas-kidney transplantation: a single-center experience and prospective analysis
    M Rossi
    Chirurgia Generale E Trapianti d Organo, La Sapienza Universita di Roma, Umberto I Policlinico di Roma, Rome, Italy
    Transplant Proc 40:2024-6. 2008
    ..6%. The results of this work add further evidence that SPK is the gold standard therapy for selected patients with end-stage CKD due to DM 1...
  18. ncbi request reprint Modifications of intracranial pressure after molecular adsorbent recirculating system treatment in patients with acute liver failure: case reports
    F Pugliese
    Dipartimento di Scienze Anestesiologiche, Medicina Critica e Terapia del Dolore, Universita degli Studi di Roma La Sapienza, Roma, Italy
    Transplant Proc 39:2042-4. 2007
    ..The aim of this study was to evaluate ICP changes after MARS treatment among patients with ALF...
  19. ncbi request reprint Outcome after liver transplantation in patients with cirrhosis and hepatocellular carcinoma
    M Rossi
    Divisione di Chirurgia Generale Trapianti d Organo, Universita La Sapienza, Rome, Italy
    Transplant Proc 39:1895-7. 2007
    ..00001). The 58 patients who underwent transplantation with a diagnosis of cirrhosis and concomitant HCC after 1999 showed even better survival than patients who underwent transplantation for end-stage liver disease without malignancy...
  20. doi request reprint Hemodynamic improvement as an additional parameter to evaluate the safety and tolerability of the molecular adsorbent recirculating system in liver failure patients
    F Pugliese
    Scienze Anestesiologiche, Medicina Critica e Terapia del Dolore, La Sapienza Universita di Roma, Rome, Italy
    Transplant Proc 40:1925-8. 2008
    ..The molecular adsorbent recirculating system (MARS) is an extracorporeal acute liver failure (ALF) support system method using albumin-enriched dialysate to remove albumin-bound toxins...
  21. ncbi request reprint Molecular adsorbent recirculating system treatment for acute hepatic failure in patients with hepatitis B undergoing chemotherapy for non-Hodgkin's lymphoma
    G Novelli
    Centro Trapianti di Organ, Azienda Policlinico Umberto I, Università degli Studi La Sapienza Roma, Rome, Italy
    Transplant Proc 37:2560-2. 2005
    ..Despite the limited number of cases, we believe that MARS can be applied to patients with a high tolerance and yield good results, but the treatment has to start at the first signs of hepatic failure...
  22. ncbi request reprint Clinical effects of use polymyxin B fixed on fibers in liver transplant patients with severe sepsis or septic shock
    F Ruberto
    Dipartimento di Scienze Anestesiologiche, Medicina Critica e Terapia del Dolore, Universita degli Studi di Roma La Sapienza, Roma, Italy
    Transplant Proc 39:1953-5. 2007
    ..The aim of this study was to evaluate the efficacy, safety, and clinical effects of direct hemoperfusion with an immobilized polymyxin B fiber column (DHP-PMX) among liver transplant patients with severe sepsis or septic shock...
  23. doi request reprint Management of hepatitis C virus infection in liver transplantation with adacolumn apheresis
    G Novelli
    Department P Stefanini of General Surgery and Organs Transplant, Sapienza University, Rome, Italy
    Transplant Proc 44:1946-52. 2012
    ..Although this study investigated the responses among a small number of patients, it documented that the Adacolumn changed cellular immunity, promoting early virologic responses...
  24. doi request reprint Multimodal therapy with combined plasmapheresis, photoapheresis, and intravenous immunoglobulin for acute antibody-mediated renal transplant rejection: a 2-year follow-up
    Q Lai
    Department of General Surgery and Organ Transplantation, Sapienza University, Rome, Italy
    Transplant Proc 43:1039-41. 2011
    ..The aim of this study was to report an initial single-center experience of combined PT and ECP with high-dose intravenous immunoglobulin (IVIg) for the treatment of AMAR...
  25. doi request reprint Preoperative donor scores and postoperative early measures of graft function: relevance to the outcome of liver transplantation
    Q Lai
    Department of General Surgery and Organ Transplantation, La Sapienza Universita di Roma, Umberto I Policlinico di Roma, Rome, Italy
    Transplant Proc 42:1209-11. 2010
    ..The aim of our review was to detect the role of preoperative scoring systems and early postoperative measures of graft function as predictive factors for the development of graft failure and recipient death...
  26. doi request reprint Glasgow coma score and tumor necrosis factor α as predictive criteria for initial poor graft function
    G Novelli
    Department P Stefanini of General Surgery and Organs Transplant, Sapienza University, Rome, Italy
    Transplant Proc 44:1820-5. 2012
    ..Validating these results with a larger number of patients, we considered these 2 factors as subjective parameters to determine outcomes and the difference between PNF and DGF...
  27. ncbi request reprint Predictive factors of recurrence of hepatocellular carcinoma after liver transplantation: a multivariate analysis
    Q Lai
    Department of General Surgery and Organ Transplantation, La Sapienza University of Rome, Umberto I Policlinic of Rome, Rome, Italy
    Transplant Proc 41:1306-9. 2009
    ..Patients with both these parameters are not candidates for OLT. Microvascular invasion is a good predictive parameter, but is impossible to detect preoperatively. New pre-OLT predictive risk factors are needed to achieve optimal results...
  28. doi request reprint Pathfast presepsin assay for early diagnosis of bacterial infections in surgical patients: preliminary study
    G Novelli
    P Stefanini Department of General Surgery and Organ Transplant, Sapienza University, Rome, Italy
    Transplant Proc 45:2750-3. 2013
    ..We evaluated the analytical and clinical performance of the Pathfast presepsin (PFP) assay system for early diagnosis of infection...
  29. ncbi request reprint Polymyxin-B endotoxin removal device: making the point on mechanisms of action, clinical effectiveness and possible future applications: review
    Franco Ruberto
    Department of Anesthesiology and Intensive Care Medicine, Sapienza Universita di Roma, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy
    Infect Disord Drug Targets 13:128-32. 2013
    ..Given that, there's still need of wider and more structured clinical studies that could steady the use of this device and widen its fields of applications. ..
  30. ncbi request reprint Survival in kidney transplantation from living donors: a single-center experience
    R Pretagostini
    Servizio Trapianti D Organo, Azienda Policlinico Umberto I, Dipartimento Paride Stefanini, Universita degli Studi La Sapienza, Rome, Italy
    Transplant Proc 36:467-9. 2004
    ..Transplantation from living donors, in Italy, is still not accepted, in particular those from unrelated donors. The aim of this paper was to present the experience of one transplant center...
  31. ncbi request reprint Predictive factors of outcome after liver transplantation in patients with cirrhosis and hepatocellular carcinoma
    M Merli
    II Gastroenterologia, Universita La Sapienza, Rome, Italy
    Transplant Proc 37:2535-40. 2005
    ..The adoption of Milan criteria for selection of cirrhotic patients has improved survival and reduced the rate of tumor recurrence. The evaluation of cumulative tumor size might further improve patient selection...
  32. doi request reprint Preliminary study of early histomorphometric changes in hepatic steatosis
    F Marinozzi
    Department of Clinical Engineering, Sapienza University of Rome, Rome, Italy
    Transplant Proc 44:1837-42. 2012
    ..0017 mm(2)). The LHR value showed that the morphometric parameter SA/PA could be quantitatively interpreted also as a functional impairment relative to the increased resistance opposing blood flow in pathologic conditions...
  33. ncbi request reprint Fenoldopam and gastric tonometry during orthotopic liver transplantation
    F Pugliese
    Dipartimento di Scienze Anestesiologiche, Medicina Critica e Terapia del Dolore, Università dedegli studi di Roma La Sapienza Universita Degli Studi di Roma La Sapienza, Roma, Italy
    Transplant Proc 39:1886-8. 2007
    ..The aim of this study was to evaluate the effects of continuous infusion of fenoldopam on splanchnic perfusion in orthotopic liver transplant (OLT) recipients...
  34. ncbi request reprint Transcriptional profile characterization for the identification of peripheral blood biomarkers in patients with cerebral aneurysms
    G Sabatino
    Neurosurgery Department, Catholic University School of Medicine, Rome, Italy
    J Biol Regul Homeost Agents 27:729-38. 2013
    ..Further PCR and Western Blotting studies are needed to confirm such findings and to identify diagnostic and prognostic markers in order to define screening protocols for intracranial aneurysms. ..
  35. ncbi request reprint Intractable pruritus in patients with hepatitis C virus
    G Novelli
    Transplant Proc 38:1089-91. 2006
    ..Due to the small number of patients the results were not significant...
  36. ncbi request reprint [Liver transplantation in swine: a model for tolerance induction]
    L M Lenti
    Sezione di Chirurgia Generale, Laboratorio di Chirurgia Sperimentale, Dipartimento di Scienze Chirurgiche Rianimatorie Riabilitative e dei Trapianti d Organo, Universita degli Studi di Pavia, Piazza Botta 10, 27100 Pavia, Italy
    Minerva Chir 61:393-402. 2006
    ..Aim of this study is to evaluate a model of liver transplantation in swine as a preliminary step for immunological studies...
  37. pmc Mutations in the hepatocyte nuclear factor-1beta gene are associated with familial hypoplastic glomerulocystic kidney disease
    C Bingham
    Department of Vascular Medicine and Diabetes Research, School of Postgraduate Medicine and Health Sciences, University of Exeter, Exeter, EX2 5AX, Devon, United Kingdom
    Am J Hum Genet 68:219-24. 2001
    ..We conclude that there is genetic heterogeneity in familial GCKD and that the hypoplastic subtype is a part of the clinical spectrum of the renal cysts and diabetes syndrome that is associated with HNF-1beta mutations...