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Publications
Non invasive evaluation of liver fibrosis in paediatric patients with nonalcoholic steatohepatitisAngelo Iacobellis
Division of Gastroenterology, Hospital Casa Sollievo della Sofferenza, IRCCS, San Giovanni Rotondo, Italy
World J Gastroenterol 12:7821-5. 2006..At multivariate analysis, BMI > 26.3 was the only independent predictor of fibrosis (OR = 5.85, 95% CI = 1.6-21). CONCLUSION: BMI helps identify children with NASH who might have fibrotic deposition in the liver...
Levels of serum ceruloplasmin associate with pediatric nonalcoholic fatty liver diseaseValerio Nobili
Unit of Liver Research, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
J Pediatr Gastroenterol Nutr 56:370-5. 2013..We investigated whether transition metals and their related proteins were related to NAFLD symptoms and their underlying processes...- The potential role of fatty liver in paediatric metabolic syndrome: a distinct phenotype with high metabolic risk?V Nobili
Metabolic and Autoimmune Liver Disease Unit, Bambino Gesu Children s Hospital, Rome, Italy
Pediatr Obes 7:e75-80. 2012..CONCLUSION: We propose that NAFLD should be routinely checked in obese subjects because early lifestyle changes may be effective in reducing the overall risk of MS... - Treatment of nonalcoholic fatty liver disease in adults and children: a closer look at the arsenalValerio Nobili
Unit of Metabolic and Autoimmune Liver Diseases, Pediatric Hospital Bambino Gesu, IRCCS, Square S Onofrio 4, 00165, Rome, Italy
J Gastroenterol 47:29-36. 2012..In this paper we review the status of current and emerging therapeutic strategies for children and adult patients with nonalcoholic steatohepatitis... - Therapeutic strategies for pediatric non-alcoholic fatty liver disease: a challenge for health care providersValerio Nobili
Liver Unit, Research Institute, Bambino Gesu Children s Hospital, S Onofrio 4 Square, Rome, Italy
World J Gastroenterol 13:2639-41. 2007..Therapeutic approaches have aimed at treating associated conditions (obesity, insulin resistance, hyperlipemia, etc) or reducing liver oxidative damage (vitamin E)... - NAFLD in children: a prospective clinical-pathological study and effect of lifestyle adviceValerio Nobili
Liver Unit, Bambino Gesu Children s Hospital, Rome, Italy
Hepatology 44:458-65. 2006..Obesity and older age are independently associated with increased liver fibrosis. A simple lifestyle advice program significantly improves insulin resistance, and the liver disease in pediatric NAFLD... - A protective effect of breastfeeding on the progression of non-alcoholic fatty liver diseaseV Nobili
Liver Unit Bambino Gesù Children s Hospital and Research Institute, Rome, Italy
Arch Dis Child 94:801-5. 2009..Here we investigated the association between early type of feeding (breastfed versus formula-fed and duration of breastfeeding) and later NAFLD development... 
The pediatric NAFLD fibrosis index: a predictor of liver fibrosis in children with non-alcoholic fatty liver diseaseValerio Nobili
Department of Hepatogastroenterology and Nutrition, Pediatric Hospital IRCCS Bambino Gesù, Via S, Onofrio 4, 00165 Rome, Italy
BMC Med 7:21. 2009..Here, we developed a simple algorithm for the prediction of liver fibrosis in children with NAFLD followed at a tertiary care center...- Elevated serum ALT in children presenting to the emergency unit: Relationship with NAFLDV Nobili
Liver Unit, Bambino Gesu Children s Hospital, Rome, Italy
Dig Liver Dis 41:749-52. 2009..Non-alcoholic fatty liver disease, ranging from hepatic steatosis to necro-inflammation with or without fibrosis (non-alcoholic steatohepatitis), is a growing clinical liver disorder in children... - Autoimmune sclerosing cholangitis in two sistersValerio Nobili
Liver Unit, Research Institute, Bambino Gesu' Children's Hospital, S. Onofrio 4 Square, 00165 Rome, Italy
Eur J Pediatr 167:107-8. 2008 - Retinol-binding protein 4: a promising circulating marker of liver damage in pediatric nonalcoholic fatty liver diseaseValerio Nobili
Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
Clin Gastroenterol Hepatol 7:575-9. 2009..We tested the serum levels of RBP4 to assess their associations with the metabolic profile and histologic features in a large well-characterized group of children with NAFLD... - Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitisValerio Nobili
Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
Hepatology 48:442-8. 2008..In patients in which likelihood ratios are not optimal to provide a reliable indication of the disease stage, liver biopsy should be considered when clinically indicated... - Low birth weight and catch-up-growth associated with metabolic syndrome: a ten year systematic reviewValerio Nobili
Bambino Gesu Children s Hospital and Research Institute, Dept of Hepato Gastroenterology and Nutrition, Rome, Italy
Pediatr Endocrinol Rev 6:241-7. 2008..study the potential role of an alternative nutritional approach to side effects of catch-up-growth... - Performance of ELF serum markers in predicting fibrosis stage in pediatric non-alcoholic fatty liver diseaseValerio Nobili
Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
Gastroenterology 136:160-7. 2009..We investigated the performance of this test in assessing liver fibrosis in children and adolescents with NAFLD, identified by biopsy... - Intrauterine growth retardation, insulin resistance, and nonalcoholic fatty liver disease in childrenValerio Nobili
Liver Unit, Research Institute, , Piazza S. Onofrio 4, 00165 Rome, Italy
Diabetes Care 30:2638-40. 2007 - Autoimmune thyroiditis associated with autoimmune hepatitisValerio Nobili
Department of Liver Disease, Research Institute, Bambino Gesu' Children's Hospital, Rome, Italy
Thyroid 15:1193-5. 2005 - Severity of liver injury and atherogenic lipid profile in children with nonalcoholic fatty liver diseaseValerio Nobili
Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
Pediatr Res 67:665-70. 2010.... - Oxidative stress parameters in paediatric non-alcoholic fatty liver diseaseValerio Nobili
Department of Hepatogastroenterology, Bambino Gesu Children s Hospital, Rome, Italy
Int J Mol Med 26:471-6. 2010..9; 95= CI 1.5-113.8; p=0.013) of a NAFLD activity score (NAS) >or=5. These results demonstrate that oxidative stress has an high prevalence in children with NAFLD and is associated with an increased severity of steatohepatitis... - Hyaluronic acid predicts hepatic fibrosis in children with nonalcoholic fatty liver diseaseValerio Nobili
Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
Transl Res 156:229-34. 2010..Additional studies are needed to test whether HA can be employed to predict liver fibrosis in pediatric populations with similar and lower prevalence of liver fibrosis... - Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trialValerio Nobili
Unit of Metabolic and Autoimmune Liver Diseases, Bambino Gesu Children s Hospital IRCCS, Square S Onofrio 4, Rome, Italy
Arch Dis Child 96:350-3. 2011..To investigate whether dietary supplementation with docosahexaenoic acid (DHA) decreases liver fat content in children with non-alcoholic fatty liver disease (NAFLD)... - Transient elastography for assessment of fibrosis in paediatric liver diseaseValerio Nobili
Liver Unit, Research Institute, Bambino Gesu Children s Hospital, Piazza S Onofrio 4, 00165 Rome, Italy
Pediatr Radiol 41:1232-8. 2011.... - The role of lifestyle changes in the management of chronic liver diseaseValerio Nobili
Metabolic and Autoimmunity Liver Unit, Bambino Gesu Children s Hospital and Research Institute, S, Onofrio Square, 4, 00165 Rome, Italy
BMC Med 9:70. 2011.... - The use of ultrasound in clinical setting for children affected by NAFLD: is it safe and accurate?Valerio Nobili
Unit of Liver Research of Bambino Gesù Children s Hospital, IRCCS, P le S Onofrio 4, 00165 Rome, Italy
Ital J Pediatr 37:36. 2011..Many non-invasive diagnostic tools have been evaluated so far. Recently the utility of ultrasonography for non-invasive diagnosis and estimation of hepatic steatosis has been demonstrated in a large prospective pediatric study... - Pediatric non-alcoholic fatty liver disease: Preventive and therapeutic value of lifestyle interventionValerio Nobili
Liver Unit, Research Institute, , S Onofrio 4 Square, 00165 Rome, Italy
World J Gastroenterol 15:6017-22. 2009..Here, we outline the clinical course, pathogenesis and management of NAFLD in children, highlighting the preventive and therapeutic value of lifestyle intervention... - Waist circumference correlates with liver fibrosis in children with non-alcoholic steatohepatitisM Manco
Department of Hepatogastroenterology and Nutrition, Paediatric Hospital Bambino Gesu, IRCCS, Rome, Italy
Gut 57:1283-7. 2008..Non-alcoholic fatty liver disease (NAFLD) is a feature of the metabolic syndrome. A contribution of metabolic syndrome, and especially of waist circumference, to liver fibrosis in children with NAFLD is strongly suspected... - Metabolic syndrome and liver histology in paediatric non-alcoholic steatohepatitisM Manco
Liver Unit, Pathology Department, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
Int J Obes (Lond) 32:381-7. 2008.... - Effect of intrauterine growth retardation on liver and long-term metabolic riskS Cianfarani
Molecular Endocrinology Unit DPUO, Bambino Gesù Children s Hospital Rina Balducci Center of Pediatric Endocrinology, Tor Vergata University, Rome, Italy
Int J Obes (Lond) 36:1270-7. 2012..The aim of this review is to provide insights into the molecular mechanisms underlying liver programming that contribute to increase the cardiometabolic risk in subjects with intrauterine growth restriction... - Impaired energy expenditure despite normal cardiovascular capacity in children with type 1 diabetesD Fintini
Cardiorespiratory and Sport Medicine Unit, Bambino Gesu Children s Hospital, IRCCS, Rome, Italy
Horm Res Paediatr 78:1-7. 2012..Benefit of fitness on children with type 1 diabetes mellitus (T1DM) is still debated. Aim: To evaluate the influence of physical activity on metabolic balance and exercise tolerance in prepubertal children affected by T1DM... - Energy expenditure and insulin sensitivity evaluation in obese children affected by hepatosteatosisD Fintini
Cardiorespiratory and Sport Medicine Unit, Bambino Gesu Children s Hospital, IRCCS, Rome, Italy
Pediatr Obes 7:e14-7. 2012.... - Insulin resistance and exercise capacity in male children and adolescents with non-alcholic fatty liver diseaseMelania Manco
Scientific Directorate, Bambino Gesu Children s Hospital and Research Institute, S Onofrio 4 Square, 00165, Rome, Italy
Acta Diabetol 46:97-104. 2009.... - Autoimmune liver diseasesC Della Corte
Hepatometabolic Department, Bambino Gesu Children s Hospital, Rome, Italy
Minerva Pediatr 64:595-606. 2012..The purpose of this review was to provide an overview of the current knowledge on pediatric autoimmune liver disease... - Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: a randomized, controlled trialValerio Nobili
Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
Hepatology 48:119-28. 2008..Alpha-tocopherol plus ascorbic acid does not seem to increase the efficacy of lifestyle intervention alone... - Leptin, free leptin index, insulin resistance and liver fibrosis in children with non-alcoholic fatty liver diseaseValerio Nobili
Liver Unit, Research Institute, , S Onofrio 4 Square, 00165 Rome, Italy
Eur J Endocrinol 155:735-43. 2006..Nevertheless, any causative role of leptin in NAFLD progression could be established. Thus, studies are needed to define whether the hormone plays a major role in the disease... - Metformin use in children with nonalcoholic fatty liver disease: an open-label, 24-month, observational pilot studyValerio Nobili
Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
Clin Ther 30:1168-76. 2008..There is no consensus on the treatment of pediatric nonalcoholic fatty liver disease (NAFLD). However, in a small pilot study conducted in 10 children, metformin has been proposed to be effective... - Effect of vitamin E on aminotransferase levels and insulin resistance in children with non-alcoholic fatty liver diseaseV Nobili
Liver Unit, , Rome, Italy
Aliment Pharmacol Ther 24:1553-61. 2006..012; F = 7.150). CONCLUSIONS: Diet and physical exercise in NAFLD children seem to lead to a significant improvement of liver function and glucose metabolism beyond any antioxidant therapy... - Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver diseaseMelania Manco
Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
Am J Clin Pathol 127:954-60. 2007..TNF-alpha alone or combined with leptin in a simple risk score can accurately predict a NAS of 5 or more. TNF-alpha seems to be a specific laboratory marker of NASH... - Albuminuria and insulin resistance in children with biopsy proven non-alcoholic fatty liver diseaseMelania Manco
Scientific Directorate, Bambino Gesu Hospital, Research Institute IRCCS, 00165, Rome, Italy
Pediatr Nephrol 24:1211-7. 2009..Longitudinal studies are needed to rule out any causative relationship between insulin resistance and urinary albumin excretion... - Aminotransferases as predictors of mortalitySandro Vento
Infectious Diseases Unit, Annunziata Hospital, 87100 Cosenza, Italy
Lancet 371:1822-3. 2008 - Nonalcoholic fatty liver disease in childrenMelania Manco
Catholic University, Rome, Italy
J Am Coll Nutr 27:667-76. 2008..In this article, we review the current concepts about paediatric NAFLD, its pathogenesis, diagnosis and treatment, with particular regard to lifestyle and foods habits... - Intima-media thickness and liver histology in obese children and adolescents with non-alcoholic fatty liver diseaseMelania Manco
Scientific Directorate, Pediatric Hospital Bambino Gesu, IRCCS, Piazza San Onofrio 4, 00165 Rome, Italy
Atherosclerosis 209:463-8. 2010..To evaluate the relationship between biopsy-proven non-alcoholic fatty liver disease (NAFLD) and carotid artery intima-media thickness (CIMT) in children and adolescents... - Endotoxin and plasminogen activator inhibitor-1 serum levels associated with nonalcoholic steatohepatitis in childrenAnna Alisi
Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
J Pediatr Gastroenterol Nutr 50:645-9. 2010..We investigated the association between serum levels of endotoxin, proinflammatory molecules, and histology in children with NAFLD... - Treatment of Wilson's disease with zinc from the time of diagnosis in pediatric patients: a single-hospital, 10-year follow-up studyMatilde Marcellini
Department of Liver Disease, Children's Hospital Bambino Ges, P.za S. Onofrio, 4, 00165 Rome
J Lab Clin Med 145:139-43. 2005..In conclusion, our findings indicate that zinc is the treatment of choice in presymptomatic pediatric patients with WD... - Psychosocial condition after liver transplantation in children: review of the literature from 2006 to 2008V Nobili
Paediatric Hospital Bambino Gesu, Rome, Italy
Transplant Proc 41:3779-83. 2009.... - Mycophenolate mofetil in pediatric liver transplant patients with renal dysfunction: preliminary dataV Nobili
Department of Liver Disease, Bambino Gesu Children s Hospital, Rome, Italy
Pediatr Transplant 7:454-7. 2003..Furthermore present data suggest that the risk of acute allograft rejection is very low when the CNI desired reduction is achieved in not too short time and absolutely when the MPA levels are strictly monitored... - Is juvenile liver biopsy unsafe? Putting an end to a common misapprehensionAndrea Pietrobattista
Liver Unit, Pediatric Hospital Bambino Gesu, 00165 Rome, Italy
Pediatr Radiol 39:959-61. 2009..In 2003, our group showed that routine use of US as a guide to liver biopsy reduces the rate of complications and provides a higher diagnostic yield... - Protein glutathionylation increases in the liver of patients with non-alcoholic fatty liver diseaseFiorella Piemonte
Molecular Medicine Unit, Chemistry Laboratory, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
J Gastroenterol Hepatol 23:e457-64. 2008..In this study, we analyzed the protein glutathionylation in non-alcoholic fatty liver disease (NAFLD) and evaluated a potential association between glutathionylation, fibrosis, and vitamin E treatment... - Screening of an Echinococcus granulosus cDNA library with IgG4 from patients with cystic echinococcosis identifies a new tegumental protein involved in the immune escapeE Ortona
Division of Immune-mediated Diseases, Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanit, Rome, Italy
Clin Exp Immunol 142:528-38. 2005..granulosus. Because the new tegumental antigen EgTeg inhibits chemotaxis, induces IL-4-positive T lymphocytes and noncomplement fixing antibodies (IgG4) it is an immunomodulatory molecule associated with chronic infection... - Co-occurrence of chronic hepatitis B virus infection and autoimmune hepatitis in a young Senegalese girlValerio Nobili
Department of Liver Diseases, , Rome cSection of Infectious Diseases, Italy
Eur J Gastroenterol Hepatol 18:927-9. 2006..Persistent HBV infection due to wild-type virus (likely acquired vertically or early in life, as the mother was HBsAg positive) may have acted as a trigger for autoimmune hepatitis in this young girl... - Combined test for UGT1A1 -3279T-->G and A(TA)nTAA polymorphisms best predicts Gilbert's syndrome in Italian pediatric patientsAlessandro Ferraris
IRCCS CSS Hospital, CSS Mendel Institute, Rome, Italy
Genet Test 10:121-5. 2006.... - Liver fibrosis and therapeutic strategies: the goal for improving metabolismClara Balsano
Laboratory of Molecular Virology and Oncology, A Cesalpino Foundation, University of Rome, Rome, Italy
Curr Drug Targets 10:505-12. 2009..Clinical relevance of drugs correcting these metabolic disturbances in the reversion of liver fibrosis will also be discussed... - Expert opinion on current therapies for nonalcoholic fatty liver diseaseClaudia Della Corte
Bambino Gesu Children s Hospital, Liver Research Unit, IRCCS, Piazzale S Onofrio 4, Rome, Italy
Expert Opin Pharmacother 12:1901-11. 2011..A multidisciplinary approach considering the risk factors and comorbidities of fatty liver will represent in the future a successful therapeutic strategy for NAFLD... - Extrahepatic portal vein thrombosis in children and adolescents: Influence of genetic thrombophilic disordersAndrea Pietrobattista
Research Institute, Bambino Gesu Children s Hospital, Piazza S Onofrio 4, 00165 Rome, Italy
World J Gastroenterol 16:6123-7. 2010..to explore the prevalence of local and genetic thrombophilic disorders as risk factors for portal vein thrombosis (PVT) in our series, the largest ever published in pediatric literature... - Association of serum interleukin-8 levels with the degree of fibrosis in infants with chronic liver diseaseValerio Nobili
Department of Liver Disease, Laboratory of Rheumatology, Research Institute, Bambino Gesu Children s Hospital, Rome, Italy
J Pediatr Gastroenterol Nutr 39:540-4. 2004..To determine the proinflammatory cytokine profile in children with biliary atresia, we measured circulating levels of interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha and IL-8... - Hepatic fibrosis in Kabuki syndromeValerio Nobili
Department of Liver Disease, Bambino Gesu Hospital, Rome, Italy
Am J Med Genet A 124:209-12. 2004..Due to the expression patterns of Notch genes, involvement of the Notch signaling pathway in the development of heart and liver anomalies in KS should be considered... - Tyrosinemia type 1: metastatic hepatoblastoma with a favorable outcomeValerio Nobili
Division of Metabolism, Bambino Gesu Children s Hospital, Rome, Italy
Pediatrics 126:e235-8. 2010..We encourage clinicians to perform more accurate evaluation of liver histology, because a neoplastic mass in a child with tyrosinemia type 1 is not the same as HCC... - A new ABCB11 mutation in two Italian children with familial intrahepatic cholestasisValerio Nobili
Hepatology, , Piazza S. Onofrio, 4-00165, Rome, Italy
J Gastroenterol 41:598-603. 2006..Our findings are expected to facilitate detection of the molecular cause of PFIC in affected families... - Bloodletting ameliorates insulin sensitivity and secretion in parallel to reducing liver iron in carriers of HFE gene mutationsFrancesco Equitani
Transfusion Medicine, SanFilippo Neri Hospital, Rome, Italy
Diabetes Care 31:3-8. 2008..To clarify the pathogenesis of diabetes associated with mutations of the hemochromatosis (HFE) gene, 17 carriers, 9 normal glucose tolerant (NGT) and 8 diabetic, were evaluated in an interventional trial... - Blind and ultrasound-guided percutaneous liver biopsy in childrenValerio Nobili
Department of Liver Disease, Bambino Gesu Children s Hospital, Piazza S Onofrio 4, 00165, Rome, Italy
Pediatr Radiol 33:772-5. 2003.... - Lifestyle advice in non-alcoholic fatty liver diseaseMelania Manco
J Gastroenterol Hepatol 22:604-5. 2007 - The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver diseaseLuca Miele
Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
Gastroenterology 135:282-291.e1. 2008..Based on its role in liver growth and repair, we explored whether Kruppel-like factor 6 (KLF6) plays a role in NAFLD progression... - Autoimmune hepatitis type 1 after Epstein-Barr virus infectionValerio Nobili
Pediatr Infect Dis J 22:387. 2003 - HCV and steatosis in childrenDonatella Comparcola
J Hepatol 45:758; author reply 758-9. 2006 - Autoimmune hemolytic anemia and autoimmune hepatitis associated with parvovirus B19 infectionValerio Nobili
Pediatr Infect Dis J 23:184-5. 2004 - Is torquetenovirus a potential cause of liver damage in children?Valerio Nobili
J Infect 50:368-9. 2005 - Are children after liver transplant more prone to non-alcoholic fatty liver disease?Valerio Nobili
Pediatr Transplant 12:611-3. 2008 - Molecular genetics of NASH: the role of polymorphismsAnna Alisi
J Hepatol 47:868-9; author reply 870-1. 2007 - Bioinformatics as tool to identify gene/protein-pathways associated with nonalcoholic fatty liver disease/nonalcoholic steatohepatitisAnna Alisi
Hepatology 46:1306; author reply 1306-7. 2007 - Childhood hepatitis C virus infectionDonatella Comparcola
J Gastroenterol Hepatol 20:1948-9. 2005 - Molecular pathogenesis of nonalcoholic steatohepatitis: today and tomorrowAnna Alisi
Am J Pathol 171:712-3; author reply 713. 2007 - Case management in children affected by non-alcoholic fatty liver diseaseValerio Nobili
J Paediatr Child Health 43:414. 2007 - How much we worry for liver fat in children?Melania Manco
Acta Paediatr 96:1373-4; author reply 1374-5. 2007 - Different fat distribution as marker of disease in nonalcholic fatty liver diseaseMelania Manco
Hepatology 46:1310-1; author reply 1312. 2007 - Measurement of advanced glycation end products may change NASH managementValerio Nobili
J Gastroenterol Hepatol 22:1354-5. 2007 - Intensive treatment and dietary fats in adolescents with nonalcoholic fatty liver diseaseMelania Manco
J Pediatr Gastroenterol Nutr 46:224. 2008 - Fulminant hepatic failure following measlesValerio Nobili
Pediatr Infect Dis J 26:766-7. 2007 - Reduced cardio-respiratory fitness in obesity with and without nonalcoholic fatty liver diseaseMelania Manco
Hepatology 48:690; author reply 690-1. 2008 - Clinical course of infection with hepatitis CSandro Vento
BMJ 332:374-5. 2006 - Glutathione metabolism and antioxidant enzymes in patients affected by nonalcoholic steatohepatitisValerio Nobili
Division of Hepatology, Children's Hospital and Research Institute Bambino Ges, Piazza S. Onofrio, 4, Rome 00165, Italy
Clin Chim Acta 355:105-11. 2005..CONCLUSIONS: Our data demonstrate an impairment of glutathione metabolism and antioxidant enzyme activities in blood of patients with NASH, supporting a consistent role of free radical cytotoxicity in the pathophysiology of the disease...