V Nobili

Summary

Country: Italy

Publications

  1. ncbi request reprint Non invasive evaluation of liver fibrosis in paediatric patients with nonalcoholic steatohepatitis
    Angelo Iacobellis
    Division of Gastroenterology, Hospital Casa Sollievo della Sofferenza, IRCCS, San Giovanni Rotondo, Italy
    World J Gastroenterol 12:7821-5. 2006
  2. ncbi request reprint Docosahexaenoic acid for the treatment of fatty liver: randomised controlled trial in children
    V Nobili
    Liver Research Unit, Bambino Gesu Children s Hospital and Research Institute, Roma, Italy Electronic address
    Nutr Metab Cardiovasc Dis 23:1066-70. 2013
  3. pmc Pediatric non alcoholic fatty liver disease: old and new concepts on development, progression, metabolic insight and potential treatment targets
    Valentina Giorgio
    Hepato metabolic Unit, Bambino Gesu Children Hospital, Rome, Italy
    BMC Pediatr 13:40. 2013
  4. doi request reprint Pediatric post-transplant metabolic syndrome: new clouds on the horizon
    Valerio Nobili
    Department of Paediatric Surgery and Transplantation Center, Bambino Gesu Children s Hospital, Roma, Italy
    Pediatr Transplant 17:216-23. 2013
  5. doi request reprint A 360-degree overview of paediatric NAFLD: recent insights
    Valerio Nobili
    Hepato Metabolic Disease Unit and Liver Research Unit, Bambino Gesu Children s Hospital, IRCCS, P le S Onofrio 4, 00165 Rome, Italy
    J Hepatol 58:1218-29. 2013
  6. doi request reprint Levels of serum ceruloplasmin associate with pediatric nonalcoholic fatty liver disease
    Valerio Nobili
    Unit of Liver Research, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    J Pediatr Gastroenterol Nutr 56:370-5. 2013
  7. doi request reprint The potential role of fatty liver in paediatric metabolic syndrome: a distinct phenotype with high metabolic risk?
    V Nobili
    Metabolic and Autoimmune Liver Disease Unit, Bambino Gesu Children s Hospital, Rome, Italy
    Pediatr Obes 7:e75-80. 2012
  8. doi request reprint Treatment of nonalcoholic fatty liver disease in adults and children: a closer look at the arsenal
    Valerio Nobili
    Unit of Metabolic and Autoimmune Liver Diseases, Pediatric Hospital Bambino Gesu, IRCCS, Square S Onofrio 4, 00165, Rome, Italy
    J Gastroenterol 47:29-36. 2012
  9. doi request reprint Hyaluronic acid predicts hepatic fibrosis in children with nonalcoholic fatty liver disease
    Valerio Nobili
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Transl Res 156:229-34. 2010
  10. ncbi request reprint Intrauterine growth retardation, insulin resistance, and nonalcoholic fatty liver disease in children
    Valerio Nobili
    Liver Unit, Research Institute, Bambino Gesu Children s Hospital, Piazza S Onofrio 4, 00165 Rome, Italy
    Diabetes Care 30:2638-40. 2007

Collaborators

Detail Information

Publications86

  1. ncbi request reprint Non invasive evaluation of liver fibrosis in paediatric patients with nonalcoholic steatohepatitis
    Angelo Iacobellis
    Division of Gastroenterology, Hospital Casa Sollievo della Sofferenza, IRCCS, San Giovanni Rotondo, Italy
    World J Gastroenterol 12:7821-5. 2006
    ..To identify the independent predictors of hepatic fibrosis in 69 children with nonalcoholic steatohepatitis (NASH) due to nonalcoholic fatty liver disease (NAFLD)...
  2. ncbi request reprint Docosahexaenoic acid for the treatment of fatty liver: randomised controlled trial in children
    V Nobili
    Liver Research Unit, Bambino Gesu Children s Hospital and Research Institute, Roma, Italy Electronic address
    Nutr Metab Cardiovasc Dis 23:1066-70. 2013
    ..Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in children. We tested whether dietary supplementation with docosahexaenoic acid (DHA) can decrease liver fat content in children with NAFLD...
  3. pmc Pediatric non alcoholic fatty liver disease: old and new concepts on development, progression, metabolic insight and potential treatment targets
    Valentina Giorgio
    Hepato metabolic Unit, Bambino Gesu Children Hospital, Rome, Italy
    BMC Pediatr 13:40. 2013
    ..This review provides an overview of current and new clinical-histological concepts of pediatric NAFLD, going through possible implications into patho-physiolocical and therapeutic perspectives...
  4. doi request reprint Pediatric post-transplant metabolic syndrome: new clouds on the horizon
    Valerio Nobili
    Department of Paediatric Surgery and Transplantation Center, Bambino Gesu Children s Hospital, Roma, Italy
    Pediatr Transplant 17:216-23. 2013
    ..With early identification and appropriate and aggressive management, excellent long-term health outcomes and acceptable graft survival can be achieved...
  5. doi request reprint A 360-degree overview of paediatric NAFLD: recent insights
    Valerio Nobili
    Hepato Metabolic Disease Unit and Liver Research Unit, Bambino Gesu Children s Hospital, IRCCS, P le S Onofrio 4, 00165 Rome, Italy
    J Hepatol 58:1218-29. 2013
    ..In this review, we discuss the recent advances made in genetics, etiopathogenesis, diagnosis, and therapeutic management of NAFLD, focusing especially on the obesity-related steatotic liver condition...
  6. doi request reprint Levels of serum ceruloplasmin associate with pediatric nonalcoholic fatty liver disease
    Valerio Nobili
    Unit of Liver Research, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    J Pediatr Gastroenterol Nutr 56:370-5. 2013
    ..We investigated whether transition metals and their related proteins were related to NAFLD symptoms and their underlying processes...
  7. doi request reprint The potential role of fatty liver in paediatric metabolic syndrome: a distinct phenotype with high metabolic risk?
    V Nobili
    Metabolic and Autoimmune Liver Disease Unit, Bambino Gesu Children s Hospital, Rome, Italy
    Pediatr Obes 7:e75-80. 2012
    ....
  8. doi request reprint Treatment of nonalcoholic fatty liver disease in adults and children: a closer look at the arsenal
    Valerio Nobili
    Unit of Metabolic and Autoimmune Liver Diseases, Pediatric Hospital Bambino Gesu, IRCCS, Square S Onofrio 4, 00165, Rome, Italy
    J Gastroenterol 47:29-36. 2012
    ..In this paper we review the status of current and emerging therapeutic strategies for children and adult patients with nonalcoholic steatohepatitis...
  9. doi request reprint Hyaluronic acid predicts hepatic fibrosis in children with nonalcoholic fatty liver disease
    Valerio Nobili
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Transl Res 156:229-34. 2010
    ..Additional studies are needed to test whether HA can be employed to predict liver fibrosis in pediatric populations with similar and lower prevalence of liver fibrosis...
  10. ncbi request reprint Intrauterine growth retardation, insulin resistance, and nonalcoholic fatty liver disease in children
    Valerio Nobili
    Liver Unit, Research Institute, Bambino Gesu Children s Hospital, Piazza S Onofrio 4, 00165 Rome, Italy
    Diabetes Care 30:2638-40. 2007
  11. ncbi request reprint Oxidative stress parameters in paediatric non-alcoholic fatty liver disease
    Valerio Nobili
    Department of Hepatogastroenterology, Bambino Gesu Children s Hospital, Rome, Italy
    Int J Mol Med 26:471-6. 2010
    ..9; 95= CI 1.5-113.8; p=0.013) of a NAFLD activity score (NAS) >or=5. These results demonstrate that oxidative stress has an high prevalence in children with NAFLD and is associated with an increased severity of steatohepatitis...
  12. ncbi request reprint Therapeutic strategies for pediatric non-alcoholic fatty liver disease: a challenge for health care providers
    Valerio Nobili
    Liver Unit, Research Institute, Bambino Gesu Children s Hospital, S Onofrio 4 Square, Rome, Italy
    World J Gastroenterol 13:2639-41. 2007
    ..Therapeutic approaches have aimed at treating associated conditions (obesity, insulin resistance, hyperlipemia, etc) or reducing liver oxidative damage (vitamin E)...
  13. pmc Pediatric non-alcoholic fatty liver disease: Preventive and therapeutic value of lifestyle intervention
    Valerio Nobili
    Liver Unit, Research Institute, , S Onofrio 4 Square, 00165 Rome, Italy
    World J Gastroenterol 15:6017-22. 2009
    ..Here, we outline the clinical course, pathogenesis and management of NAFLD in children, highlighting the preventive and therapeutic value of lifestyle intervention...
  14. doi request reprint A protective effect of breastfeeding on the progression of non-alcoholic fatty liver disease
    V Nobili
    Liver Unit Bambino Gesù Children s Hospital and Research Institute, Rome, Italy
    Arch Dis Child 94:801-5. 2009
    ..Here we investigated the association between early type of feeding (breastfed versus formula-fed and duration of breastfeeding) and later NAFLD development...
  15. pmc The pediatric NAFLD fibrosis index: a predictor of liver fibrosis in children with non-alcoholic fatty liver disease
    Valerio Nobili
    Department of Hepatogastroenterology and Nutrition, Pediatric Hospital IRCCS Bambino Gesù, Via S, Onofrio 4, 00165 Rome, Italy
    BMC Med 7:21. 2009
    ..Here, we developed a simple algorithm for the prediction of liver fibrosis in children with NAFLD followed at a tertiary care center...
  16. doi request reprint Elevated serum ALT in children presenting to the emergency unit: Relationship with NAFLD
    V Nobili
    Liver Unit, Bambino Gesu Children s Hospital, Rome, Italy
    Dig Liver Dis 41:749-52. 2009
    ..Non-alcoholic fatty liver disease, ranging from hepatic steatosis to necro-inflammation with or without fibrosis (non-alcoholic steatohepatitis), is a growing clinical liver disorder in children...
  17. doi request reprint Retinol-binding protein 4: a promising circulating marker of liver damage in pediatric nonalcoholic fatty liver disease
    Valerio Nobili
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Clin Gastroenterol Hepatol 7:575-9. 2009
    ..We tested the serum levels of RBP4 to assess their associations with the metabolic profile and histologic features in a large well-characterized group of children with NAFLD...
  18. ncbi request reprint Low birth weight and catch-up-growth associated with metabolic syndrome: a ten year systematic review
    Valerio Nobili
    Bambino Gesu Children s Hospital and Research Institute, Dept of Hepato Gastroenterology and Nutrition, Rome, Italy
    Pediatr Endocrinol Rev 6:241-7. 2008
    ..study the potential role of an alternative nutritional approach to side effects of catch-up-growth...
  19. doi request reprint Performance of ELF serum markers in predicting fibrosis stage in pediatric non-alcoholic fatty liver disease
    Valerio Nobili
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Gastroenterology 136:160-7. 2009
    ..We investigated the performance of this test in assessing liver fibrosis in children and adolescents with NAFLD, identified by biopsy...
  20. doi request reprint Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial
    Valerio Nobili
    Unit of Metabolic and Autoimmune Liver Diseases, Bambino Gesu Children s Hospital IRCCS, Square S Onofrio 4, Rome, Italy
    Arch Dis Child 96:350-3. 2011
    ..To investigate whether dietary supplementation with docosahexaenoic acid (DHA) decreases liver fat content in children with non-alcoholic fatty liver disease (NAFLD)...
  21. pmc The role of lifestyle changes in the management of chronic liver disease
    Valerio Nobili
    Metabolic and Autoimmunity Liver Unit, Bambino Gesu Children s Hospital and Research Institute, S, Onofrio Square, 4, 00165 Rome, Italy
    BMC Med 9:70. 2011
    ....
  22. ncbi request reprint Autoimmune sclerosing cholangitis in two sisters
    Valerio Nobili
    Liver Unit, Research Institute, Bambino Gesu Children s Hospital, S Onofrio 4 Square, 00165 Rome, Italy
    Eur J Pediatr 167:107-8. 2008
  23. ncbi request reprint Autoimmune thyroiditis associated with autoimmune hepatitis
    Valerio Nobili
    Department of Liver Disease, Research Institute, Bambino Gesu Children s Hospital, Rome, Italy
    Thyroid 15:1193-5. 2005
  24. doi request reprint Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis
    Valerio Nobili
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Hepatology 48:442-8. 2008
    ..In patients in which likelihood ratios are not optimal to provide a reliable indication of the disease stage, liver biopsy should be considered when clinically indicated...
  25. pmc The use of ultrasound in clinical setting for children affected by NAFLD: is it safe and accurate?
    Valerio Nobili
    Unit of Liver Research of Bambino Gesù Children s Hospital, IRCCS, P le S Onofrio 4, 00165 Rome, Italy
    Ital J Pediatr 37:36. 2011
    ..Many non-invasive diagnostic tools have been evaluated so far. Recently the utility of ultrasonography for non-invasive diagnosis and estimation of hepatic steatosis has been demonstrated in a large prospective pediatric study...
  26. ncbi request reprint NAFLD in children: a prospective clinical-pathological study and effect of lifestyle advice
    Valerio Nobili
    Liver Unit, Bambino Gesu Children s Hospital, Rome, Italy
    Hepatology 44:458-65. 2006
    ..Obesity and older age are independently associated with increased liver fibrosis. A simple lifestyle advice program significantly improves insulin resistance, and the liver disease in pediatric NAFLD...
  27. doi request reprint Transient elastography for assessment of fibrosis in paediatric liver disease
    Valerio Nobili
    Liver Unit, Research Institute, Bambino Gesu Children s Hospital, Piazza S Onofrio 4, 00165 Rome, Italy
    Pediatr Radiol 41:1232-8. 2011
    ....
  28. doi request reprint Severity of liver injury and atherogenic lipid profile in children with nonalcoholic fatty liver disease
    Valerio Nobili
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Pediatr Res 67:665-70. 2010
    ....
  29. ncbi request reprint Waist circumference correlates with liver fibrosis in children with non-alcoholic steatohepatitis
    M Manco
    Department of Hepatogastroenterology and Nutrition, Paediatric Hospital Bambino Gesu, IRCCS, Rome, Italy
    Gut 57:1283-7. 2008
    ..Non-alcoholic fatty liver disease (NAFLD) is a feature of the metabolic syndrome. A contribution of metabolic syndrome, and especially of waist circumference, to liver fibrosis in children with NAFLD is strongly suspected...
  30. ncbi request reprint Metabolic syndrome and liver histology in paediatric non-alcoholic steatohepatitis
    M Manco
    Liver Unit, Pathology Department, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Int J Obes (Lond) 32:381-7. 2008
    ....
  31. doi request reprint Effect of intrauterine growth retardation on liver and long-term metabolic risk
    S Cianfarani
    Molecular Endocrinology Unit DPUO, Bambino Gesù Children s Hospital Rina Balducci Center of Pediatric Endocrinology, Tor Vergata University, Rome, Italy
    Int J Obes (Lond) 36:1270-7. 2012
    ..The aim of this review is to provide insights into the molecular mechanisms underlying liver programming that contribute to increase the cardiometabolic risk in subjects with intrauterine growth restriction...
  32. doi request reprint Impaired energy expenditure despite normal cardiovascular capacity in children with type 1 diabetes
    D Fintini
    Cardiorespiratory and Sport Medicine Unit, Bambino Gesu Children s Hospital, IRCCS, Rome, Italy
    Horm Res Paediatr 78:1-7. 2012
    ..Benefit of fitness on children with type 1 diabetes mellitus (T1DM) is still debated. Aim: To evaluate the influence of physical activity on metabolic balance and exercise tolerance in prepubertal children affected by T1DM...
  33. doi request reprint Energy expenditure and insulin sensitivity evaluation in obese children affected by hepatosteatosis
    D Fintini
    Cardiorespiratory and Sport Medicine Unit, Bambino Gesu Children s Hospital, IRCCS, Rome, Italy
    Pediatr Obes 7:e14-7. 2012
    ....
  34. ncbi request reprint Autoimmune liver diseases
    C Della Corte
    Hepatometabolic Department, Bambino Gesu Children s Hospital, Rome, Italy
    Minerva Pediatr 64:595-606. 2012
    ..The purpose of this review was to provide an overview of the current knowledge on pediatric autoimmune liver disease...
  35. doi request reprint Insulin resistance and exercise capacity in male children and adolescents with non-alcholic fatty liver disease
    Melania Manco
    Scientific Directorate, Bambino Gesu Children s Hospital and Research Institute, S Onofrio 4 Square, 00165, Rome, Italy
    Acta Diabetol 46:97-104. 2009
    ....
  36. ncbi request reprint Leptin, free leptin index, insulin resistance and liver fibrosis in children with non-alcoholic fatty liver disease
    Valerio Nobili
    Liver Unit, Research Institute, Bambino Gesu Children s Hospital, S Onofrio 4 Square, 00165 Rome, Italy
    Eur J Endocrinol 155:735-43. 2006
    ..A role for leptin has been claimed. This study aims to evaluate the relationship between leptin, insulin resistance (IR) and NAFLD in children...
  37. doi request reprint Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: a randomized, controlled trial
    Valerio Nobili
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Hepatology 48:119-28. 2008
    ..The improvement in all these parameters was not significantly different between the two groups...
  38. ncbi request reprint Effect of vitamin E on aminotransferase levels and insulin resistance in children with non-alcoholic fatty liver disease
    V Nobili
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Aliment Pharmacol Ther 24:1553-61. 2006
    ..Few data are available on the effect of antioxidants in paediatric non-alcoholic fatty liver disease (NAFLD)...
  39. doi request reprint Metformin use in children with nonalcoholic fatty liver disease: an open-label, 24-month, observational pilot study
    Valerio Nobili
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Clin Ther 30:1168-76. 2008
    ..There is no consensus on the treatment of pediatric nonalcoholic fatty liver disease (NAFLD). However, in a small pilot study conducted in 10 children, metformin has been proposed to be effective...
  40. doi request reprint Early left ventricular abnormality/dysfunction in obese children affected by NAFLD
    D Fintini
    Endocrinology and Diabetology Unit, Bambino Gesu Children s Hospital IRCCS, Rome, Italy Electronic address
    Nutr Metab Cardiovasc Dis 24:72-4. 2014
    ..Aim of the study was to detect cardiac abnormalities/dysfunction in a paediatric population of NAFLD...
  41. doi request reprint Psychosocial condition after liver transplantation in children: review of the literature from 2006 to 2008
    V Nobili
    Paediatric Hospital Bambino Gesu, Rome, Italy
    Transplant Proc 41:3779-83. 2009
    ....
  42. ncbi request reprint Nonalcoholic fatty liver disease in children
    Melania Manco
    Catholic University, Rome, Italy
    J Am Coll Nutr 27:667-76. 2008
    ..In this article, we review the current concepts about paediatric NAFLD, its pathogenesis, diagnosis and treatment, with particular regard to lifestyle and foods habits...
  43. ncbi request reprint Albuminuria and insulin resistance in children with biopsy proven non-alcoholic fatty liver disease
    Melania Manco
    Scientific Directorate, Bambino Gesu Hospital, Research Institute IRCCS, 00165, Rome, Italy
    Pediatr Nephrol 24:1211-7. 2009
    ..Longitudinal studies are needed to rule out any causative relationship between insulin resistance and urinary albumin excretion...
  44. ncbi request reprint Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease
    Melania Manco
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Am J Clin Pathol 127:954-60. 2007
    ..TNF-alpha alone or combined with leptin in a simple risk score can accurately predict a NAS of 5 or more. TNF-alpha seems to be a specific laboratory marker of NASH...
  45. doi request reprint Intima-media thickness and liver histology in obese children and adolescents with non-alcoholic fatty liver disease
    Melania Manco
    Scientific Directorate, Pediatric Hospital Bambino Gesu, IRCCS, Piazza San Onofrio 4, 00165 Rome, Italy
    Atherosclerosis 209:463-8. 2010
    ..To evaluate the relationship between biopsy-proven non-alcoholic fatty liver disease (NAFLD) and carotid artery intima-media thickness (CIMT) in children and adolescents...
  46. doi request reprint Aminotransferases as predictors of mortality
    Sandro Vento
    Infectious Diseases Unit, Annunziata Hospital, 87100 Cosenza, Italy
    Lancet 371:1822-3. 2008
  47. pmc Randomised clinical trial: the beneficial effects of VSL#3 in obese children with non-alcoholic steatohepatitis
    A Alisi
    Hepato Metabolic Disease Unit and Liver Research Unit, Bambino Gesu Children s Hospital, IRCCS, Rome, Italy
    Aliment Pharmacol Ther 39:1276-85. 2014
    ..Gut microbiota modifiers may have beneficial effects of non-alcoholic fatty liver disease (NAFLD) but randomised controlled trials (RCT) are lacking in children...
  48. doi request reprint Liver transplantation for refractory severe pruritus related to widespread multifocal hepatic focal nodular hyperplasia (FNH) in a child: case report and review of literature
    L Merli
    Transplantation Center, Ospedale Pediatrico Bambino Gesu, Roma, Italy
    Pediatr Transplant 16:E265-8. 2012
    ..The operation and the follow-up were uneventful, allowing full recovery and disappearance of pruritus...
  49. ncbi request reprint Endotoxin and plasminogen activator inhibitor-1 serum levels associated with nonalcoholic steatohepatitis in children
    Anna Alisi
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    J Pediatr Gastroenterol Nutr 50:645-9. 2010
    ..We investigated the association between serum levels of endotoxin, proinflammatory molecules, and histology in children with NAFLD...
  50. ncbi request reprint Treatment of Wilson's disease with zinc from the time of diagnosis in pediatric patients: a single-hospital, 10-year follow-up study
    Matilde Marcellini
    Department of Liver Disease, Children s Hospital Bambino Gesu, P za S Onofrio, 4, 00165 Rome
    J Lab Clin Med 145:139-43. 2005
    ..In conclusion, our findings indicate that zinc is the treatment of choice in presymptomatic pediatric patients with WD...
  51. ncbi request reprint Mycophenolate mofetil in pediatric liver transplant patients with renal dysfunction: preliminary data
    V Nobili
    Department of Liver Disease, Bambino Gesu Children s Hospital, Rome, Italy
    Pediatr Transplant 7:454-7. 2003
    ..Furthermore present data suggest that the risk of acute allograft rejection is very low when the CNI desired reduction is achieved in not too short time and absolutely when the MPA levels are strictly monitored...
  52. ncbi request reprint Protein glutathionylation increases in the liver of patients with non-alcoholic fatty liver disease
    Fiorella Piemonte
    Molecular Medicine Unit, Chemistry Laboratory, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    J Gastroenterol Hepatol 23:e457-64. 2008
    ..In this study, we analyzed the protein glutathionylation in non-alcoholic fatty liver disease (NAFLD) and evaluated a potential association between glutathionylation, fibrosis, and vitamin E treatment...
  53. doi request reprint Is juvenile liver biopsy unsafe? Putting an end to a common misapprehension
    Andrea Pietrobattista
    Liver Unit, Pediatric Hospital Bambino Gesu, 00165 Rome, Italy
    Pediatr Radiol 39:959-61. 2009
    ..In 2003, our group showed that routine use of US as a guide to liver biopsy reduces the rate of complications and provides a higher diagnostic yield...
  54. pmc Screening of an Echinococcus granulosus cDNA library with IgG4 from patients with cystic echinococcosis identifies a new tegumental protein involved in the immune escape
    E Ortona
    Division of Immune mediated Diseases, Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Clin Exp Immunol 142:528-38. 2005
    ..granulosus. Because the new tegumental antigen EgTeg inhibits chemotaxis, induces IL-4-positive T lymphocytes and noncomplement fixing antibodies (IgG4) it is an immunomodulatory molecule associated with chronic infection...
  55. ncbi request reprint Combined test for UGT1A1 -3279T-->G and A(TA)nTAA polymorphisms best predicts Gilbert's syndrome in Italian pediatric patients
    Alessandro Ferraris
    IRCCS CSS Hospital, CSS Mendel Institute, Rome, Italy
    Genet Test 10:121-5. 2006
    ....
  56. ncbi request reprint Liver fibrosis and therapeutic strategies: the goal for improving metabolism
    Clara Balsano
    Laboratory of Molecular Virology and Oncology, A Cesalpino Foundation, University of Rome, Rome, Italy
    Curr Drug Targets 10:505-12. 2009
    ..Clinical relevance of drugs correcting these metabolic disturbances in the reversion of liver fibrosis will also be discussed...
  57. ncbi request reprint Co-occurrence of chronic hepatitis B virus infection and autoimmune hepatitis in a young Senegalese girl
    Valerio Nobili
    Department of Liver Diseases, Bambino Gesu Children s Hospital, Rome cSection of Infectious Diseases, Italy
    Eur J Gastroenterol Hepatol 18:927-9. 2006
    ..Persistent HBV infection due to wild-type virus (likely acquired vertically or early in life, as the mother was HBsAg positive) may have acted as a trigger for autoimmune hepatitis in this young girl...
  58. doi request reprint Expert opinion on current therapies for nonalcoholic fatty liver disease
    Claudia Della Corte
    Bambino Gesu Children s Hospital, Liver Research Unit, IRCCS, Piazzale S Onofrio 4, Rome, Italy
    Expert Opin Pharmacother 12:1901-11. 2011
    ..Therefore, new treatments based on pathogenetic mechanisms leading to NAFLD are under evaluation to establish an effective pharmacological therapy for this disorder...
  59. pmc Extrahepatic portal vein thrombosis in children and adolescents: Influence of genetic thrombophilic disorders
    Andrea Pietrobattista
    Research Institute, Bambino Gesu Children s Hospital, Piazza S Onofrio 4, 00165 Rome, Italy
    World J Gastroenterol 16:6123-7. 2010
    ..to explore the prevalence of local and genetic thrombophilic disorders as risk factors for portal vein thrombosis (PVT) in our series, the largest ever published in pediatric literature...
  60. ncbi request reprint Bloodletting ameliorates insulin sensitivity and secretion in parallel to reducing liver iron in carriers of HFE gene mutations
    Francesco Equitani
    Transfusion Medicine, SanFilippo Neri Hospital, Rome, Italy
    Diabetes Care 31:3-8. 2008
    ..To clarify the pathogenesis of diabetes associated with mutations of the hemochromatosis (HFE) gene, 17 carriers, 9 normal glucose tolerant (NGT) and 8 diabetic, were evaluated in an interventional trial...
  61. ncbi request reprint Hepatic fibrosis in Kabuki syndrome
    Valerio Nobili
    Department of Liver Disease, Bambino Gesu Hospital, Rome, Italy
    Am J Med Genet A 124:209-12. 2004
    ..Due to the expression patterns of Notch genes, involvement of the Notch signaling pathway in the development of heart and liver anomalies in KS should be considered...
  62. ncbi request reprint Blind and ultrasound-guided percutaneous liver biopsy in children
    Valerio Nobili
    Department of Liver Disease, Bambino Gesu Children s Hospital, Piazza S Onofrio 4, 00165, Rome, Italy
    Pediatr Radiol 33:772-5. 2003
    ....
  63. ncbi request reprint Association of serum interleukin-8 levels with the degree of fibrosis in infants with chronic liver disease
    Valerio Nobili
    Department of Liver Disease, Laboratory of Rheumatology, Research Institute, Bambino Gesu Children s Hospital, Rome, Italy
    J Pediatr Gastroenterol Nutr 39:540-4. 2004
    ..To determine the proinflammatory cytokine profile in children with biliary atresia, we measured circulating levels of interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha and IL-8...
  64. ncbi request reprint A new ABCB11 mutation in two Italian children with familial intrahepatic cholestasis
    Valerio Nobili
    Hepatology, IRCCS Bambino Gesù Hospital, Piazza S Onofrio, 4 00165, Rome, Italy
    J Gastroenterol 41:598-603. 2006
    ..Our findings are expected to facilitate detection of the molecular cause of PFIC in affected families...
  65. doi request reprint Tyrosinemia type 1: metastatic hepatoblastoma with a favorable outcome
    Valerio Nobili
    Division of Metabolism, Bambino Gesu Children s Hospital, Rome, Italy
    Pediatrics 126:e235-8. 2010
    ..We encourage clinicians to perform more accurate evaluation of liver histology, because a neoplastic mass in a child with tyrosinemia type 1 is not the same as HCC...
  66. ncbi request reprint HCV and steatosis in children
    Donatella Comparcola
    J Hepatol 45:758; author reply 758-9. 2006
  67. ncbi request reprint Autoimmune hepatitis type 1 after Epstein-Barr virus infection
    Valerio Nobili
    Pediatr Infect Dis J 22:387. 2003
  68. ncbi request reprint Lifestyle advice in non-alcoholic fatty liver disease
    Melania Manco
    J Gastroenterol Hepatol 22:604-5. 2007
  69. pmc The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease
    Luca Miele
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom
    Gastroenterology 135:282-291.e1. 2008
    ..Based on its role in liver growth and repair, we explored whether Kruppel-like factor 6 (KLF6) plays a role in NAFLD progression...
  70. ncbi request reprint Is torquetenovirus a potential cause of liver damage in children?
    Valerio Nobili
    J Infect 50:368-9. 2005
  71. ncbi request reprint Glutathione metabolism and antioxidant enzymes in patients affected by nonalcoholic steatohepatitis
    Valerio Nobili
    Division of Hepatology, Children s Hospital and Research Institute Bambino Gesu, Piazza S Onofrio, 4, Rome 00165, Italy
    Clin Chim Acta 355:105-11. 2005
    ..Furthermore, we analysed the catalytic activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione transferase (GST), and glutathione reductase (GR) in blood of patients...
  72. ncbi request reprint Molecular genetics of NASH: the role of polymorphisms
    Anna Alisi
    J Hepatol 47:868-9; author reply 870-1. 2007
  73. ncbi request reprint Autoimmune hemolytic anemia and autoimmune hepatitis associated with parvovirus B19 infection
    Valerio Nobili
    Pediatr Infect Dis J 23:184-5. 2004
  74. doi request reprint Intensive treatment and dietary fats in adolescents with nonalcoholic fatty liver disease
    Melania Manco
    J Pediatr Gastroenterol Nutr 46:224. 2008
  75. ncbi request reprint Are children after liver transplant more prone to non-alcoholic fatty liver disease?
    Valerio Nobili
    Pediatr Transplant 12:611-3. 2008
  76. ncbi request reprint Bioinformatics as tool to identify gene/protein-pathways associated with nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
    Anna Alisi
    Hepatology 46:1306; author reply 1306-7. 2007
  77. ncbi request reprint Childhood hepatitis C virus infection
    Donatella Comparcola
    J Gastroenterol Hepatol 20:1948-9. 2005
  78. ncbi request reprint Different fat distribution as marker of disease in nonalcholic fatty liver disease
    Melania Manco
    Hepatology 46:1310-1; author reply 1312. 2007
  79. pmc Clinical course of infection with hepatitis C
    Sandro Vento
    BMJ 332:374-5. 2006
  80. ncbi request reprint Fulminant hepatic failure following measles
    Valerio Nobili
    Pediatr Infect Dis J 26:766-7. 2007
  81. ncbi request reprint How much we worry for liver fat in children?
    Melania Manco
    Acta Paediatr 96:1373-4; author reply 1374-5. 2007
  82. ncbi request reprint Measurement of advanced glycation end products may change NASH management
    Valerio Nobili
    J Gastroenterol Hepatol 22:1354-5. 2007
  83. pmc Molecular pathogenesis of nonalcoholic steatohepatitis: today and tomorrow
    Anna Alisi
    Am J Pathol 171:712-3; author reply 713. 2007
  84. ncbi request reprint Case management in children affected by non-alcoholic fatty liver disease
    Valerio Nobili
    J Paediatr Child Health 43:414. 2007
  85. doi request reprint Reduced cardio-respiratory fitness in obesity with and without nonalcoholic fatty liver disease
    Melania Manco
    Hepatology 48:690; author reply 690-1. 2008