Laura Gasparini

Summary

Affiliation: Nicox Research Institute
Country: Italy

Publications

  1. ncbi request reprint Does insulin dysfunction play a role in Alzheimer's disease?
    Laura Gasparini
    Nicox Research Institute, Via Ariosto 21, 20091 Bresso, Milan, Italy
    Trends Pharmacol Sci 23:288-93. 2002
  2. ncbi request reprint Potential roles of insulin and IGF-1 in Alzheimer's disease
    Laura Gasparini
    Nicox Research Institute, Via Ariosto 21, 20091 Bresso, Milan, Italy
    Trends Neurosci 26:404-6. 2003
  3. ncbi request reprint Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures
    Laura Gasparini
    Nicox Research Institute, Bresso, Milan, Italy
    J Neurochem 88:337-48. 2004
  4. ncbi request reprint Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease
    Laura Gasparini
    Nicox Research Institute, Bresso, Milan, Italy
    Brain Res Brain Res Rev 48:400-8. 2005
  5. ncbi request reprint Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action
    Laura Gasparini
    Nicox Research Institute, 20091 Bresso, Milan, Italy
    J Neurochem 91:521-36. 2004
  6. ncbi request reprint Modulation of iNOS expression by a nitric oxide-releasing derivative of the natural antioxidant ferulic acid in activated RAW 264.7 macrophages
    Daniela Ronchetti
    Nicox Research Institute, Via Ariosto 21, 20091 Bresso, Milan, Italy
    Eur J Pharmacol 532:162-9. 2006
  7. pmc Interaction of tau protein with the dynactin complex
    Enrico Magnani
    Department of Clinical Neurosciences, Brain Repair Centre, University of Cambridge, Cambridge, UK
    EMBO J 26:4546-54. 2007
  8. ncbi request reprint Frontotemporal dementia with tau pathology
    Laura Gasparini
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    Neurodegener Dis 4:236-53. 2007
  9. ncbi request reprint Dynamic regulation of microglial functions by the non-steroidal anti-inflammatory drug NCX 2216: implications for chronic treatments of neurodegenerative diseases
    Antonietta Bernardo
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Neurobiol Dis 22:25-32. 2006
  10. ncbi request reprint Nuclear receptor peroxisome proliferator-activated receptor-gamma is activated in rat microglial cells by the anti-inflammatory drug HCT1026, a derivative of flurbiprofen
    Antonietta Bernardo
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
    J Neurochem 92:895-903. 2005

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Does insulin dysfunction play a role in Alzheimer's disease?
    Laura Gasparini
    Nicox Research Institute, Via Ariosto 21, 20091 Bresso, Milan, Italy
    Trends Pharmacol Sci 23:288-93. 2002
    ..Insulin also affects the metabolism of beta-amyloid, the main constituent of AD amyloid pathology. Here, we discuss clinical and biological data that highlight potential targets for therapeutic intervention...
  2. ncbi request reprint Potential roles of insulin and IGF-1 in Alzheimer's disease
    Laura Gasparini
    Nicox Research Institute, Via Ariosto 21, 20091 Bresso, Milan, Italy
    Trends Neurosci 26:404-6. 2003
    ..This review discusses available biological data that highlight the therapeutic potential of the insulin-IGF-1 signaling pathway in AD...
  3. ncbi request reprint Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures
    Laura Gasparini
    Nicox Research Institute, Bresso, Milan, Italy
    J Neurochem 88:337-48. 2004
    ..The present findings show that only a few non-selective NSAIDs possess Abeta-lowering properties and therefore have a profile potentially relevant to their clinical use in AD...
  4. ncbi request reprint Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease
    Laura Gasparini
    Nicox Research Institute, Bresso, Milan, Italy
    Brain Res Brain Res Rev 48:400-8. 2005
    ..It is still unclear which effects on microglia will prove most beneficial. Ultimately, clinical studies in AD patients will provide the best information as to whether selected NSAIDs will improve this devastating disease...
  5. ncbi request reprint Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action
    Laura Gasparini
    Nicox Research Institute, 20091 Bresso, Milan, Italy
    J Neurochem 91:521-36. 2004
    ..Here, we will discuss how the combination of anti-amyloidogenic and anti-inflammatory activities of certain NSAIDs may produce a profile potentially relevant to their clinical use as disease-modifying agents for the treatment of AD...
  6. ncbi request reprint Modulation of iNOS expression by a nitric oxide-releasing derivative of the natural antioxidant ferulic acid in activated RAW 264.7 macrophages
    Daniela Ronchetti
    Nicox Research Institute, Via Ariosto 21, 20091 Bresso, Milan, Italy
    Eur J Pharmacol 532:162-9. 2006
    ..Thus, NCX 2057 represents a new prototype drug for the treatment of disorders associated with chronic inflammation and oxidative stress...
  7. pmc Interaction of tau protein with the dynactin complex
    Enrico Magnani
    Department of Clinical Neurosciences, Brain Repair Centre, University of Cambridge, Cambridge, UK
    EMBO J 26:4546-54. 2007
    ..These findings, which suggest a direct involvement of tau in axonal transport, have implications for understanding the pathogenesis of tauopathies...
  8. ncbi request reprint Frontotemporal dementia with tau pathology
    Laura Gasparini
    Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    Neurodegener Dis 4:236-53. 2007
    ..The range of tau pathology identified in FTDP-17 recapitulates the tau pathology present in sporadic tauopathies and indicates that tau dysfunction plays a major role also in these diseases...
  9. ncbi request reprint Dynamic regulation of microglial functions by the non-steroidal anti-inflammatory drug NCX 2216: implications for chronic treatments of neurodegenerative diseases
    Antonietta Bernardo
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Neurobiol Dis 22:25-32. 2006
    ..The dynamic regulation of the functional state of activated microglia by NCX 2216 helps explaining recent findings in Alzheimer's disease animal models and may offer new therapeutic opportunities for treating neurodegenerative diseases...
  10. ncbi request reprint Nuclear receptor peroxisome proliferator-activated receptor-gamma is activated in rat microglial cells by the anti-inflammatory drug HCT1026, a derivative of flurbiprofen
    Antonietta Bernardo
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
    J Neurochem 92:895-903. 2005
    ..The results suggest that HCT1026 may exert additional anti-inflammatory actions through PPAR-gamma activation, allowing a more effective control of microglial activation and brain inflammation...
  11. ncbi request reprint A nitric oxide releasing derivative of flurbiprofen inhibits experimental autoimmune encephalomyelitis
    Roberto Furlan
    Neuroimmunology Unit, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Neuroimmunol 150:10-9. 2004
    ....
  12. ncbi request reprint Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid
    Gary L Wenk
    Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724, USA
    J Neurochem 89:484-93. 2004
    ....
  13. ncbi request reprint A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface
    Jae Yoon Leem
    Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Illinois 60637, USA
    Neurobiol Dis 11:64-82. 2002
    ..Collectively, our findings provide evidence that PS1 regulates the glycosylation and intracellular trafficking of APP and select membrane proteins...
  14. doi request reprint Beta-amyloid and glutamate receptors
    Laura Gasparini
    Department of Neuroscience and Brain Technologies, The Italian Institute of Technology, 16163 Genova, Italy
    Exp Neurol 212:1-4. 2008