E Mocchegiani

Summary

Affiliation: Neurobiology of Aging Laboratory
Country: Italy

Publications

  1. ncbi Zinc: dietary intake and impact of supplementation on immune function in elderly
    Eugenio Mocchegiani
    Ctr Nutrition and Ageing, Italian National Research Centres on Ageing INRCA, Via Birarelli 8, 60121, Ancona, Italy
    Age (Dordr) 35:839-60. 2013
  2. ncbi Metallothioneins, ageing and cellular senescence: a future therapeutic target
    Eugenio Mocchegiani
    Trans Res Ctr of Nutrition and Ageing, IRCCS INRCA, Via Birarelli 8, 60121, Ancona, Italy
    Curr Pharm Des 19:1753-64. 2013
  3. ncbi Cu to Zn ratio, physical function, disability, and mortality risk in older elderly (ilSIRENTE study)
    Eugenio Mocchegiani
    Centre of Nutrition and Ageing, Scientific and Technological Area, INRCA, Ancona, Italy
    Age (Dordr) 34:539-52. 2012
  4. ncbi Micronutrient (Zn, Cu, Fe)-gene interactions in ageing and inflammatory age-related diseases: implications for treatments
    Eugenio Mocchegiani
    Translational Research Center in Nutrition and Ageing, Scientific and Techonologic Area, Italian National Research Centres on Ageing, Ancona, Italy
    Ageing Res Rev 11:297-319. 2012
  5. ncbi Metalloproteases/anti-metalloproteases imbalance in chronic obstructive pulmonary disease: genetic factors and treatment implications
    Eugenio Mocchegiani
    Translational Research Centre of Nutrition and Ageing, Scientific and Technological Area, Italian National Research Centres on Ageing INRCA, Ancona, Italy
    Curr Opin Pulm Med 17:S11-9. 2011
  6. ncbi Zinc, metallothioneins and immunosenescence: effect of zinc supply as nutrigenomic approach
    Eugenio Mocchegiani
    Nutrition and Ageing Centre, Italian National Research Centres on Ageing INRCA, Via Birarelli 8, 60121, Ancona, Italy
    Biogerontology 12:455-65. 2011
  7. ncbi Zinc-binding proteins (metallothionein and alpha-2 macroglobulin) and immunosenescence
    Eugenio Mocchegiani
    Immunology Center, Section Nutrition, Immunity and Ageing, Research Department I N R C A, Via Birarelli 8, 60121 Ancona, Italy
    Exp Gerontol 41:1094-107. 2006
  8. ncbi Zinc, metallothioneins, longevity: effect of zinc supplementation on antioxidant response: a Zincage study
    Eugenio Mocchegiani
    Immunolgy Center, Section of Nutrigenomics and Immunosenenscence, Res Dept INRCA, Ancona, Italy
    Rejuvenation Res 11:419-23. 2008
  9. ncbi Plasticity of neuroendocrine-thymus interactions during ontogeny and ageing: role of zinc and arginine
    Eugenio Mocchegiani
    Immunology Ctr Section Nutrition, Immunity and Ageing, Res Department INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Ageing Res Rev 5:281-309. 2006
  10. ncbi Zinc homeostasis in aging: two elusive faces of the same "metal"
    Eugenio Mocchegiani
    Immunology Centre, Nutrition, Immunity, and Aging Section, INRCA Research Department, Ancona, Italy
    Rejuvenation Res 9:351-4. 2006

Detail Information

Publications105 found, 100 shown here

  1. ncbi Zinc: dietary intake and impact of supplementation on immune function in elderly
    Eugenio Mocchegiani
    Ctr Nutrition and Ageing, Italian National Research Centres on Ageing INRCA, Via Birarelli 8, 60121, Ancona, Italy
    Age (Dordr) 35:839-60. 2013
    ..We summarise the main causes of low zinc dietary intake in elderly reporting an update on the impact of zinc supplementation upon the immune response also on the basis of individual IL-6 polymorphism...
  2. ncbi Metallothioneins, ageing and cellular senescence: a future therapeutic target
    Eugenio Mocchegiani
    Trans Res Ctr of Nutrition and Ageing, IRCCS INRCA, Via Birarelli 8, 60121, Ancona, Italy
    Curr Pharm Des 19:1753-64. 2013
    ..Hence, MT could be directly or indirectly involved in the modulation of cellular senescent state and might represent a possible therapeutic target against the accumulation of dysfunctional senescent cells...
  3. ncbi Cu to Zn ratio, physical function, disability, and mortality risk in older elderly (ilSIRENTE study)
    Eugenio Mocchegiani
    Centre of Nutrition and Ageing, Scientific and Technological Area, INRCA, Ancona, Italy
    Age (Dordr) 34:539-52. 2012
    ..In this context, further investigations need to be carried out...
  4. ncbi Micronutrient (Zn, Cu, Fe)-gene interactions in ageing and inflammatory age-related diseases: implications for treatments
    Eugenio Mocchegiani
    Translational Research Center in Nutrition and Ageing, Scientific and Techonologic Area, Italian National Research Centres on Ageing, Ancona, Italy
    Ageing Res Rev 11:297-319. 2012
    ....
  5. ncbi Metalloproteases/anti-metalloproteases imbalance in chronic obstructive pulmonary disease: genetic factors and treatment implications
    Eugenio Mocchegiani
    Translational Research Centre of Nutrition and Ageing, Scientific and Technological Area, Italian National Research Centres on Ageing INRCA, Ancona, Italy
    Curr Opin Pulm Med 17:S11-9. 2011
    ....
  6. ncbi Zinc, metallothioneins and immunosenescence: effect of zinc supply as nutrigenomic approach
    Eugenio Mocchegiani
    Nutrition and Ageing Centre, Italian National Research Centres on Ageing INRCA, Via Birarelli 8, 60121, Ancona, Italy
    Biogerontology 12:455-65. 2011
    ....
  7. ncbi Zinc-binding proteins (metallothionein and alpha-2 macroglobulin) and immunosenescence
    Eugenio Mocchegiani
    Immunology Center, Section Nutrition, Immunity and Ageing, Research Department I N R C A, Via Birarelli 8, 60121 Ancona, Italy
    Exp Gerontol 41:1094-107. 2006
    ..Therefore, zinc supplementation is useful to achieve health longevity because these zinc-binding proteins may regain their original protective task against oxidative damage with, thus, a beneficial impact on immune response...
  8. ncbi Zinc, metallothioneins, longevity: effect of zinc supplementation on antioxidant response: a Zincage study
    Eugenio Mocchegiani
    Immunolgy Center, Section of Nutrigenomics and Immunosenenscence, Res Dept INRCA, Ancona, Italy
    Rejuvenation Res 11:419-23. 2008
    ..Here, the choice of old subjects for zinc supplementation is discussed in relation to their genetic background of MT and IL-6, because both affect intracellular zinc homeostasis...
  9. ncbi Plasticity of neuroendocrine-thymus interactions during ontogeny and ageing: role of zinc and arginine
    Eugenio Mocchegiani
    Immunology Ctr Section Nutrition, Immunity and Ageing, Res Department INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Ageing Res Rev 5:281-309. 2006
    ....
  10. ncbi Zinc homeostasis in aging: two elusive faces of the same "metal"
    Eugenio Mocchegiani
    Immunology Centre, Nutrition, Immunity, and Aging Section, INRCA Research Department, Ancona, Italy
    Rejuvenation Res 9:351-4. 2006
    ..Restoring functional zinc homeostasis in aging people is an attractive field for antiaging research, but requires further knowledge than the current state of the art...
  11. ncbi Zinc dyshomeostasis, ageing and neurodegeneration: implications of A2M and inflammatory gene polymorphisms
    Eugenio Mocchegiani
    Immunology Center, Section Nutrition, Immunity and Ageing, Research Department, Italian National Research Centres on Ageing, Ancona, Italy
    J Alzheimers Dis 12:101-9. 2007
    ..The role played by MT and A2M is reported in ageing and Alzheimer's disease and on some polymorphisms of A2M and inflammatory genes (cytokines and their receptors) because some of them may be affected by zinc, via MT homeostasis...
  12. ncbi Nutrient-gene interaction in ageing and successful ageing. A single nutrient (zinc) and some target genes related to inflammatory/immune response
    Eugenio Mocchegiani
    Immunology Ctr Section Nutrition, Immunity and Ageing, Research Department INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Mech Ageing Dev 127:517-25. 2006
    ....
  13. ncbi Brain, aging and neurodegeneration: role of zinc ion availability
    Eugenio Mocchegiani
    Immunology Ctr Section Nutrition, Immunity and Aging, Res Department INRCA, Ancona 60100, Via Birarelli 8, 60121, Italy
    Prog Neurobiol 75:367-90. 2005
    ....
  14. ncbi Chronobiology and effects of the age on the immune function: nutritional and genetic background
    E Mocchegiani
    Italian National Research Centres on Ageing (INRCA, Research Department, Section: Nutrigenomic and Immunosenescence, Ancona, Italy
    Vet Res Commun 31:109-13. 2007
  15. ncbi Zinc, metallothioneins, and longevity--effect of zinc supplementation: zincage study
    Eugenio Mocchegiani
    Immunology Center Section Nutrigenomic and Immunosenescence, Research Department, Italian National Research Center on Ageing, Ancona, Italy
    Ann N Y Acad Sci 1119:129-46. 2007
    ....
  16. ncbi Zinc deficiency and IL-6 -174G/C polymorphism in old people from different European countries: effect of zinc supplementation. ZINCAGE study
    Eugenio Mocchegiani
    Nutrigenomic and Immunosenescence Laboratory, Research Department, INRCA, Ancona, Italy
    Exp Gerontol 43:433-44. 2008
    ..A possible explanation for the conflicting data on the identification of IL-6-174G as a "risk allele" based on different dietary intake in the studied population is also suggested...
  17. ncbi Zinc signalling and subcellular distribution: emerging targets in type 2 diabetes
    Eugenio Mocchegiani
    Laboratory of Nutrigenomic and Immunosenescence, Research Department INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Trends Mol Med 14:419-28. 2008
    ..Increasing knowledge of the mechanisms of Zn homeostasis and signalling should promote the development of targeted interventions with the potential to reduce the burden of disease...
  18. ncbi Zinc-gene interaction related to inflammatory/immune response in ageing
    Eugenio Mocchegiani
    Immunology Center Laboratory of Nutrigenomic and Immunosenescence, Research Department, INRCA, Via Birarelli 8, 60121, Ancona, Italy
    Genes Nutr 3:61-75. 2008
    ..Therefore, the zinc-gene (IL-6, TNF-alpha, Hsp70-2) interactions, via MT homeostasis, are crucial to achieve successful ageing...
  19. ncbi Zinc, metallothioneins and longevity: interrelationships with niacin and selenium
    E Mocchegiani
    Immunology Center, Laboratory of Nutrigenomic and Immunosenescence, Research Department INRCA, Via Birarelli, 8, 60121, Ancona, Italy
    Curr Pharm Des 14:2719-32. 2008
    ..The association "zinc plus selenium" improves humoral immunity in old subjects after influenza vaccination. The association "zinc plus niacin" in elderly is actually in progress...
  20. ncbi Possible new antiaging strategies related to neuroendocrine-immune interactions
    Eugenio Mocchegiani
    Immunology Center Laboratory of Nutrigenomic and Immunosenescence, Research Department INRCA, Ancona, Italy
    Neuroimmunomodulation 15:344-50. 2008
    ..Their role as possible antiaging strategies in healthy people in relation to neuroendocrine-immune responses and zinc ion bioavailability is reported and discussed...
  21. ncbi NK and NKT cells in aging and longevity: role of zinc and metallothioneins
    Eugenio Mocchegiani
    Nutrigenomic and Immunosenescence Laboratory, Istituto Nazionale Riposo e Cura per Anziani INRCA, Ancona, Italy
    J Clin Immunol 29:416-25. 2009
    ....
  22. ncbi Diet (zinc)-gene interaction related to inflammatory/immune response in ageing: possible link with frailty syndrome?
    Eugenio Mocchegiani
    Ctr Nutrition and Ageing, Scientific and Technological Area, IRCCS INRCA, 60121 Ancona, Italy
    Biogerontology 11:589-95. 2010
    ....
  23. ncbi Zinc, metallothioneins and immunosenescence
    E Mocchegiani
    Centre Nutrition and Ageing, Italian National Research Centres on Ageing INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Proc Nutr Soc 69:290-9. 2010
    ..The genetic variations of the IL-6-174G/C locus when associated with those of the MT1A+647A/C locus are useful tools for the choice of old people for zinc supplementation...
  24. ncbi NK and NKT cell functions in immunosenescence
    Eugenio Mocchegiani
    Section Nutrition, Immunity and Aging, Immunology Centre, Research Department INRCA, 60121, Ancona, Italy
    Aging Cell 3:177-84. 2004
    ..The role played by the neuroendocrine-immune network and by nutritional factors, such as zinc, in maintaining NK and NKT cell functions in aging is discussed...
  25. ncbi Zinc, immune plasticity, aging, and successful aging: role of metallothionein
    Eugenio Mocchegiani
    Immunology Center, Section Nutrition, Immunity and Ageing, Research Department I N R C A, Via Birarelli 8, 60121, Ancona, Italy
    Ann N Y Acad Sci 1019:127-34. 2004
    ..Therefore, zinc-bound MT homeostasis is crucial in conferring liver immune plasticity with subsequent successful aging...
  26. ncbi Melatonin administration in tumor-bearing mice (intact and pinealectomized) in relation to stress, zinc, thymulin and IL-2
    E Mocchegiani
    Immunology Center, Gerontology Research Department, Italian National Research Centres on Aging, Ancona
    Int J Immunopharmacol 21:27-46. 1999
    ....
  27. ncbi Contribution of zinc to reduce CD4+ risk factor for 'severe' infection relapse in aging: parallelism with HIV
    E Mocchegiani
    Immunology Centre, Gerontol, Res Dept, N Masera, Italian National Research Centres on Aging, Ancona
    Int J Immunopharmacol 21:271-81. 1999
    ..Since zinc deficiency is correlated with CD4+ depletion, this latter may also be good diagnostic marker to detect 'clear immunodeficiency' in aging, as in HIV condition...
  28. ncbi The variations during the circadian cycle of liver CD1d-unrestricted NK1.1+TCR gamma/delta+ cells lead to successful ageing. Role of metallothionein/IL-6/gp130/PARP-1 interplay in very old mice
    Eugenio Mocchegiani
    Immunology Center, Section Nutrition, Immunity and Ageing, Res Department, Italian National Research Centres on Ageing, Via Birarelli 8, 60121, Ancona, Italy
    Exp Gerontol 39:775-88. 2004
    ..1(+)TCR gamma/delta(+) cells, where MT, IL-6, gp130 are the main upstream protagonists, and PARP-1 is the main downstream protagonist in immunosenescence...
  29. ncbi Metallothioneins (I+II) and thyroid-thymus axis efficiency in old mice: role of corticosterone and zinc supply
    Eugenio Mocchegiani
    Section Nutrition, Immunity and Ageing, Immunology Centre, Research Department of Gerontology and Geriatrics Nino Masera, Italian National Research Centre on Ageing, Via Birarelli 8, 60121, Ancona, Italy
    Mech Ageing Dev 123:675-94. 2002
    ..Therefore, Zn-MTs (I+II) are crucial in zinc homeostasis for endocrine-immune efficiency during the entire life assuming a role of potential and novel 'biological clock of ageing'...
  30. ncbi Presence of links between zinc and melatonin during the circadian cycle in old mice: effects on thymic endocrine activity and on the survival
    E Mocchegiani
    Immunology Center, Gerontol Res Dept, Italian National Research Centres on Aging, Ancona, Italy
    J Neuroimmunol 86:111-22. 1998
    ..The beneficial effect of the links between zinc and melatonin on thymic functions during the circadian cycle, may be extended to a prolonged survival in aging, where, however, zinc may be more involved...
  31. ncbi Zinc, T-cell pathways, aging: role of metallothioneins
    E Mocchegiani
    Immunology Centre, Research Department, Institute National Research Centers on Aging, Ancona, Italy
    Mech Ageing Dev 106:183-204. 1998
    ....
  32. ncbi MtmRNA gene expression, via IL-6 and glucocorticoids, as potential genetic marker of immunosenescence: lessons from very old mice and humans
    Eugenio Mocchegiani
    Research Department, Section of Nutrition, Immunity and Ageing, Immunology Center, INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Exp Gerontol 37:349-57. 2002
    ..This assumption is reinforced by low MTmRNA in lymphocytes of nonagenarians and young-adult people in comparison with elderly and Down's syndrome subjects...
  33. ncbi Nutritional zinc, oxidative stress and immunosenescence: biochemical, genetic, and lifestyle implications for healthy ageing
    Eugenio Mocchegiani
    Immunology Ctr. (Section Nutrition, Immunity and Ageing) Res. Dept. Italian National Research Centres on Ageing (INRCA, Ancona, Italy
    Biogerontology 5:271-3. 2004
  34. ncbi Different age-related effects of thymectomy in myasthenia gravis: role of thymoma, zinc, thymulin, IL-2 and IL-6
    E Mocchegiani
    Immunology Center, Section Nutrition, Immunity and Aging, Gerontological Research Department Nino Masera, Italian National Research Centers on Aging INRCA, Via Birarelli 8, 60121, Ancona, Italy
    Mech Ageing Dev 117:79-91. 2000
    ..Because autoimmune phenomena may rise in aging, a parallelism with altered immune functions during aging is discussed...
  35. ncbi Zinc, infections and immunosenescence
    E Mocchegiani
    Immunology Centre Section Nutrition, Immunity and Ageing Research Department Nino Masera, Italian National Research Centres on Ageing I N R C A, Via Birarelli 8, 60121 Ancona, Italy
    Mech Ageing Dev 121:21-35. 2000
    ....
  36. ncbi Zinc-bound metallothioneins as potential biological markers of ageing
    E Mocchegiani
    Immunology Center, Section Nutrition, Immunity and Ageing, Italian National Research Centres on Ageing INRCA, Ancona, Italy
    Brain Res Bull 55:147-53. 2001
    ..Altogether these data indicate that zinc-bound MTs (I+II) can be considered as novel potential markers of ageing...
  37. ncbi Zinc and immunoresistance to infection in aging: new biological tools
    E Mocchegiani
    Immunology Centre, Research Department Nino Masera, Italian National Research Centres on Aging I N R C A, Via Birarelli 8, 60121, Ancona, Italy
    Trends Pharmacol Sci 21:205-8. 2000
    ..This article reviews the biochemical pathways through which zinc might act to increase immunoresistance to infection in the elderly...
  38. ncbi Zinc, metallothioneins, immune responses, survival and ageing
    E Mocchegiani
    Immunology Centre, Geriatric and Gerontological Research Department Nino Masera, Italian National Research Centres on Ageing I N R C A, Via Birarelli 8, 60121 Ancona, Italy
    Biogerontology 1:133-43. 2000
    ..Because of increased MT gene expression and protein levels in the liver and atrophic thymus of old mice, MTs are proposed as genetic markers of immunosenescence...
  39. ncbi Metallothionein isoforms (I+II and III) and interleukin-6 in the hippocampus of old rats: may their concomitant increments lead to neurodegeneration?
    Eugenio Mocchegiani
    Immunology Centre Section Nutrition, Immunity and Ageing, Res Dept INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Brain Res Bull 63:133-42. 2004
    ..As a consequence, compensatory phenomena between MT isoforms may not occur in the old hippocampus due to chronic stress-like condition elicited by high persistent levels of interleukin-6...
  40. ncbi Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply
    Eugenio Mocchegiani
    Immunology Center Section Nutrition, Immunity and Ageing, Research Department Italian National Research Centres on Ageing INRCA, Via Birarelli 8, 60121, Ancona, Italy
    Mech Ageing Dev 124:459-68. 2003
    ..Therefore, the zinc ion bioavailability by zinc-bound MTs homeostasis is pivotal to reach health longevity and successful ageing...
  41. ncbi The -308G/A polymorphism of TNF-alpha influences immunological parameters in old subjects affected by infectious diseases
    C Cipriano
    Immunology Ctr Section of Nutrition, Immunity and Ageing Res Department INRCA, Ancona, Italy
    Int J Immunogenet 32:13-8. 2005
    ..These data strongly suggest that the genetic screening of the -308G/A polymorphism may be a valid tool for identification of subjects needing a more appropriate therapy when affected by acute and/or recurrent infectious diseases...
  42. ncbi Role of zinc and alpha2 macroglobulin on thymic endocrine activity and on peripheral immune efficiency (natural killer activity and interleukin 2) in cervical carcinoma
    E Mocchegiani
    Immunology Centre, Research Department, Institute National Research Centres on Aging, Ancona, Italy
    Br J Cancer 79:244-50. 1999
    ..Thus, physiological zinc treatment in cervical carcinoma maybe restores impaired central and peripheral immune efficiency...
  43. ncbi Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population
    Catia Cipriano
    Immunology Ctr Section Nutrition and Immunosenescence, Res Dept INRCA, Via Birarelli 8, 60121, Ancona, Italy
    Biogerontology 7:357-65. 2006
    ..Therefore the +647 MT1a polymorphism more affects MTs induction and zinc release, which are indispensable to undertake the inflammatory status under control and subsequently to reach healthy longevity...
  44. ncbi Metallothionein (I+II) confers, via c-myc, immune plasticity in oldest mice: model of partial hepatectomy/liver regeneration
    Catia Cipriano
    Immunology Ctr Section Nutrition Immunity and Ageing Res Dept, Italian National Centres on Ageing I N R C A, Via Birarelli 8, 60121 Ancona, Italy
    Mech Ageing Dev 124:877-86. 2003
    ..The combination of immune depression and enhanced c-myc, via high MT, may trigger the appearance of age-related degenerative diseases...
  45. ncbi BMI, life-style and psychological conditions in a sample of elderly Italian men and women
    F Marcellini
    INRCA, Scientific Technological Area, Center of Psycho Social Aspects of Aging, Ancona, Italy
    J Nutr Health Aging 14:515-22. 2010
    ..To identify the relationship among cognitive status, psychological conditions, anthropometric measurements and life-style in a sample of elderly Italian men and women...
  46. ncbi +647 A/C and +1245 MT1A polymorphisms in the susceptibility of diabetes mellitus and cardiovascular complications
    R Giacconi
    Immunology Center Section Nutrition, Immunity and Ageing, Research Department INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Mol Genet Metab 94:98-104. 2008
    ..Moreover, C+ carriers in DCVD patients presented a worse glycemic control, a reduced iZnR and a higher MT levels, suggesting a possible role of MT in diabetic cardiovascular complications...
  47. ncbi Interrelationships among brain, endocrine and immune response in ageing and successful ageing: role of metallothionein III isoform
    Robertina Giacconi
    Immunology Center, Section Nutrition, Immunity and Ageing, Research Department Italian National Research Centres on Ageing INRCA, Via Birarelli 8, 60121, Ancona, Italy
    Mech Ageing Dev 124:371-8. 2003
    ..Therefore, a correct MTs homeostasis is pivotal for brain-endocrine-immune response in order to reach successful ageing...
  48. ncbi The -174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing
    Robertina Giacconi
    Immunology Centre Sect Nutrition, Immunity and Ageing, Research Department of INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Exp Gerontol 39:621-8. 2004
    ..As a consequence, more convenient therapies may be prepared for a complete recovery...
  49. ncbi Novel -209A/G MT2A polymorphism in old patients with type 2 diabetes and atherosclerosis: relationship with inflammation (IL-6) and zinc
    Robertina Giacconi
    Immunology Center Section Nutrition, Immunity and Ageing, Res Dept, INRCA, Via Birarelli 8, 60121, Ancona, Italy
    Biogerontology 6:407-13. 2005
    ..Hence, the novel -209A/G MT2A polymorphism may be a further useful tool for the prevention, diagnosis and therapy of these combined pathologies in the elderly...
  50. ncbi Neuroendocrine-thymus interactions. I. In vitro modulation of thymic factor secretion by thyroid hormones
    E Mocchegiani
    Dipartimento Richerche Gerontologiche e Geriatriche, Istituto Nazionale Ricovero e Cura per Anziani INRCA, Ancona, Italy
    J Endocrinol Invest 13:139-47. 1990
    ..These findings support the idea that the modulation of thyroid hormones on thymic endocrine activity is directly exerted at thymic level...
  51. ncbi Obesity and body mass index (BMI) in relation to life-style and psycho-social aspects
    F Marcellini
    Center of Psycho Social Aspects of Aging, Scientific Technological Area, INRCA Italian National Institute on Aging, Ancona, Italy
    Arch Gerontol Geriatr 49:195-206. 2009
    ..For this reason, greater insight of the factors related to the development of obesity is required to develop treatment strategies weight-loss prevention programs...
  52. ncbi In vitro and in vivo effects of mercuric chloride on thymic endocrine activity, NK and NKT cell cytotoxicity, cytokine profiles (IL-2, IFN-gamma, IL-6): role of the nitric oxide-L-arginine pathway
    Lory Santarelli
    Occupational Medicine, Medical School Faculty, Polytechnic University of Marche, Educational Center, Via Tronto 10 A, 60020 Torrette, Ancona, Italy
    Int Immunopharmacol 6:376-89. 2006
    ..L-arginine is also able to reduce glomerular kidney IgG antibodies deposits induced by higher dose of HgCl2 administration...
  53. ncbi Distinctive modulation of inflammatory and metabolic parameters in relation to zinc nutritional status in adult overweight/obese subjects
    Laura Costarelli
    Research Department, Italian National Research Centres on Ageing INRCA, Ancona, Italy
    J Nutr Biochem 21:432-7. 2010
    ....
  54. ncbi Accumulation of cells with short telomeres is associated with impaired zinc homeostasis and inflammation in old hypertensive participants
    Catia Cipriano
    Immunology Center, Research Department Istituto Nazionale Riposo e Cura per Anziani, Ancona, Italy
    J Gerontol A Biol Sci Med Sci 64:745-51. 2009
    ..The determination of % CST could be a more reliable means than the simple measure of telomere length as fundamental parameter in ageing to determine whether individuals are still able to respond to stress...
  55. ncbi Involvement of -308 TNF-alpha and 1267 Hsp70-2 polymorphisms and zinc status in the susceptibility of coronary artery disease (CAD) in old patients
    Robertina Giacconi
    Immunolgy Ctr Section Nutrition, Immunity and Ageing, Res Dept INRCA, Via Birarelli 8, 60121, Ancona, Italy
    Biogerontology 7:347-56. 2006
    ..B + A+ and B + A- carriers seem more predisposed to ischaemic events; conversely, B - A- genotype may be considered a protective marker against CAD...
  56. ncbi The +838 C/G MT2A polymorphism, metals, and the inflammatory/immune response in carotid artery stenosis in elderly people
    Robertina Giacconi
    Immunology Center Section of Nutrition, Immunity, and Ageing, Research Department INRCA, Ancona, Italy
    Mol Med 13:388-95. 2007
    ..In conclusion, the +838 C/G MT2A polymorphism seems to influence inflammatory markers, zinc availability, NK cell cytotoxicity, and trace element status, all of which may promote CS development...
  57. ncbi 1267 HSP70-2 polymorphism as a risk factor for carotid plaque rupture and cerebral ischaemia in old type 2 diabetes-atherosclerotic patients
    Robertina Giacconi
    Immunolgy Ctr Sect Nutrition, Immunity and Ageing Res Department INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Mech Ageing Dev 126:866-73. 2005
    ..57, p < 0.05) Hence, 1267 HSP70-2 polymorphism may be of use in identifying B+ NIDDM patients at risk for carotid plaque rupture and cerebral ischaemia...
  58. ncbi Interrelationship among neutrophil efficiency, inflammation, antioxidant activity and zinc pool in very old age
    Fausto Moroni
    Cytology Ctr, Res. Dept, INRCA, Ancona, Italy
    Biogerontology 6:271-81. 2005
    ..Therefore, a more correct interrelationship among neutrophil efficiency, inflammation, antioxidant activity and zinc pool exists in successful ageing with subsequent more effectiveness to control the inflammatory response to pathogens...
  59. ncbi Reversibility of thymulin production impairment by L-arginine supplementation in mice exposed to inorganic mercury
    L Santarelli
    Insititue of Occupational Medicine, University of Ancona, Polo Didattico Via Tronto 10, Ospedale de Torrette, Ancona, Italy
    Int J Immunopathol Pharmacol 17:123-8. 2004
    ..e. peanuts, stock fish. We suggest that the daily arginine intake may account for individual susceptibility to the mercury-induced immunological effects which are found in mercury occupationally exposed workers...
  60. ncbi Recovery of low thymic hormone levels in cancer patients by lysine-arginine combination
    E Mocchegiani
    Immunology Centre, Gerontology Research Department, Italian National Research Centres on Ageing INRCA, Ancona, Italy
    Int J Immunopharmacol 12:365-71. 1990
    ..It is suggested that such an effect is mediated through the known secretagogue activity of the amino acids on the pituitary release of growth hormone, which has a modulating effect on the thymic endocrine activity...
  61. ncbi Psychosocial and biochemical interactions in aging: preliminary results from an Italian old sample of "Zincage" project
    F Marcellini
    Social Gerontology Unit, Research Department, INRCA, Via S Margherita, 5 I 60100 Ancona, Italy
    Arch Gerontol Geriatr 44:259-69. 2007
    ..These preliminary results showed an interrelationship among serum albumin value and psychosocial aspects in Italian old population, suggesting that low albumin values may be involved in impaired psychological dimensions...
  62. ncbi Zinc-dependent low thymic hormone level in type I diabetes
    E Mocchegiani
    Gerontology Research Department, Italian National Research Centers on Aging, Ancona
    Diabetes 38:932-7. 1989
    ..The zinc-dependent failure of thymic hormone, present even in fairly compensated diabetic conditions, might account for the apparent insulin-independent immunological abnormalities associated with type I diabetes...
  63. ncbi Combination of biomarkers to predict mortality in elderly patients with myocardial infarction
    Fabiola Olivieri
    Center of Genetic and Molecular Biology, Cardiology CCU Unit, Center of Statistics, Center of Immunology and Nutrigenomics, Center of Citology, Italian National Research Centers on Aging I N R C A, Ancona, Italy
    Mech Ageing Dev 129:231-7. 2008
    ..Our study was designed to improve the capability of mortality risk stratification in elderly AMI patients through the concurrent evaluations of different biomarkers, including genetic markers...
  64. ncbi Zinc status, psychological and nutritional assessment in old people recruited in five European countries: Zincage study
    Fiorella Marcellini
    Social Gerontology Unit, Res Dept, INRCA Italian National Research Centres on Ageing, Via S Margherita 5, 60100, Ancona, Italy
    Biogerontology 7:339-45. 2006
    ....
  65. ncbi Plasma copper/zinc ratio: an inflammatory/nutritional biomarker as predictor of all-cause mortality in elderly population
    Marco Malavolta
    Laboratory of Nutrigenomic and Immunosenescence, INRCA, Via Birarelli 8, 60121, Ancona, Italy
    Biogerontology 11:309-19. 2010
    ..Cu/Zn ratio may be considered an important clinical inflammatory-nutritional biomarker as well as a significant predictor of all-cause mortality in over 70-year-olds...
  66. ncbi Genetic polymorphisms of inflammatory cytokines and myocardial infarction in the elderly
    Fabiola Olivieri
    Centre of Genetic and Molecular Biology, Research Department, Italian National Research Centre on Aging, Ancona, Italy
    Mech Ageing Dev 127:552-9. 2006
    ....
  67. ncbi The effect of chronic aluminum(III) administration on the nervous system of aged rats: clues to understand its suggested role in Alzheimer's disease
    Patrizia Fattoretti
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    J Alzheimers Dis 5:437-44. 2003
    ....
  68. ncbi Psychosocial aspects and zinc status: is there a relationship with successful aging?
    Fiorella Marcellini
    Social Gerontology Unit, INRCA Research Department, Italian National Research Centres on Aging, Ancona, Italy
    Rejuvenation Res 9:333-7. 2006
    ..This further suggests that a zinc deficiency, via hypoalbumin values, is involved in impaired psychological characteristics in the elderly...
  69. ncbi Synaptic and mitochondrial physiopathologic changes in the aging nervous system and the role of zinc ion homeostasis
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    Mech Ageing Dev 127:590-6. 2006
    ..Thus, a transient imbalance of free zinc ion concentration in the cytosol ([Zn2+]i) can be considered an unfavourable trigger of subtle mitochondrial damage and synaptic pathology...
  70. ncbi Zinc in elderly people: effects of zinc supplementation on psychological dimensions in dependence of IL-6 -174 polymorphism: a Zincage study
    Fiorella Marcellini
    Gerontological and Psychological Center, Research Department, INRCA, Ancona, Italy
    Rejuvenation Res 11:479-83. 2008
    ..On the basis of IL-6 -174 polymorphism, significant restoration occurs for PSS, especially in Greece and Poland, less for MMSE and GDS, after zinc supplementation, suggesting zinc is important in reducing stress in elderly people...
  71. ncbi Single and three-color flow cytometry assay for intracellular zinc ion availability in human lymphocytes with Zinpyr-1 and double immunofluorescence: relationship with metallothioneins
    Marco Malavolta
    Immunology Centre, Section Nutrition, Immunity and Aging, Research Department of the ItalianNational Research Centre on Aging INRCA, Ancona, Italy
    Cytometry A 69:1043-53. 2006
    ....
  72. ncbi Pro-inflammatory genetic background and zinc status in old atherosclerotic subjects
    Robertina Giacconi
    Immunolgy Center, Laboratory of Nutrigenomic and Immunosenenscence, Research Department, INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Ageing Res Rev 7:306-18. 2008
    ..The detection of candidate genes related to inflammation and promoting AT and their reciprocal influence/interaction with zinc status might allow earlier appropriate dietary interventions in genetically susceptible subjects...
  73. ncbi Association of MT1A haplotype with cardiovascular disease and antioxidant enzyme defense in elderly Greek population: comparison with an Italian cohort
    Robertina Giacconi
    Nutrition and Aging, INRCA, Ancona, Italy
    J Nutr Biochem 21:1008-14. 2010
    ..In conclusion, +1245 MT1A polymorphism and +647/+1245 MT1A haplotype are implicated in CVD in Greece but not in Italy, suggesting a role of gene-diet interaction in the disease predisposition...
  74. ncbi Metallothionein downregulation in very old age: a phenomenon associated with cellular senescence?
    Marco Malavolta
    Immunology Center, Section of Nutrition, Immunity and Ageing, Res Department INRCA, Ancona, Italy
    Rejuvenation Res 11:455-9. 2008
    ..These results suggest that phenomena observed in very old people can be at least partially attributed to diminished cell proliferation...
  75. ncbi L-arginine reduces mercury accumulation in thymus of mercury-exposed mice: role of nitric oxide synthase activity and metallothioneins
    Massimo Bracci
    Department of Molecular Pathology and Innovative Therapies, Occupational Medicine, Polytechnic University of Marche, Ancona, Italy
    Ind Health 46:567-74. 2008
    ..Reduced accumulation of Hg2+ in mice dosed with L-arginine was probably related to greater NO production and NO-MTs interactions...
  76. ncbi l-Arginine normalizes NOS activity and zinc-MT homeostasis in the kidney of mice chronically exposed to inorganic mercury
    Francesco Piacenza
    Department of Molecular Pathology and Innovative Therapies, Occupational Medicine, Polytechnic University of Marche, Torrette, Ancona, Italy
    Toxicol Lett 189:200-5. 2009
    ..l-arginine treatment recovers NOS activity and induces a normalization of MT induction, plasma creatinine values and urinary proteins excretion, suggesting that l-arginine may limit kidney damages by Hg exposure...
  77. ncbi Noninvasive neonatal thymus graft into the axillary cavity extends the lifespan of old mice
    Andrea Basso
    INRCA, Scientific and Technological Research, Ancona, Italy
    Rejuvenation Res 13:288-91. 2010
    ..Using a Piantanelli parametric model of survivorship, we found a significant change in mortality rate between the two groups (thymus graft and controls)...
  78. ncbi CD14 C (-260)T polymorphism, atherosclerosis, elderly: role of cytokines and metallothioneins
    Robertina Giacconi
    Immunolgy Center Section Nutrition, Immunity and Ageing Research Department INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Int J Cardiol 120:45-51. 2007
    ..A functional polymorphism in the promoter of the CD14 gene (CD14 C-260T) was associated with coronary heart disease and atherosclerosis albeit with conflicting data...
  79. ncbi Modulation of genes involved in zinc homeostasis in old low-grade atherosclerotic patients under effects of HMG-CoA reductase inhibitors
    Laura Costarelli
    Immunology Center, Section of Nutrition, Immunity and Ageing, Research Department, INRCA, Ancona, Italy
    Rejuvenation Res 11:287-91. 2008
    ....
  80. ncbi A novel Zip2 Gln/Arg/Leu codon 2 polymorphism is associated with carotid artery disease in aging
    Robertina Giacconi
    Immunolgy Center, Section of Nutrition, Immunity, and Ageing, Research Department INRCA, Ancona, Italy
    Rejuvenation Res 11:297-300. 2008
    ..47.5%), and a reduced TT frequency (6% vs. 10%) (p < 0.05 by chi(2) test). In conclusion, Zip2 Gln/Arg/Leu polymorphism plays a role in the susceptibility to carotid artery disease...
  81. ncbi Relationship of job satisfaction, psychological distress and stress-related biological parameters among healthy nurses: a longitudinal study
    Monica Amati
    Department of Molecular Pathology and Innovative Therapies, Clinic of Occupational Medicine, Polytechnic University of Marche, Ancona, Italy
    J Occup Health 52:31-8. 2010
    ....
  82. ncbi New trends in biomedical aging research
    Marco Malavolta
    Center of Immunology, INRCA Research Department, Ancona, Italy
    Gerontology 50:420-4. 2004
    ..CONCLUSIONS: Although many problems will remain unsolved for long, it seems that a common consensus has been raised towards the possible serious impact of these strategies on the development of knowledge around the mechanisms of aging...
  83. ncbi In vivo effect of alpha-bisabolol, a nontoxic sesquiterpene alcohol, on the induction of spontaneous mammary tumors in HER-2/neu transgenic mice
    Laura Costarelli
    Center on Nutrition and Ageing, INRCA, Ancona, Italy
    Oncol Res 18:409-18. 2010
    ..Such effectiveness could be important to achieve goals for a possible combination of BISA to conventional therapies in breast cancer and to tumor surgical removal (adjuvant therapy), as suggested for other sesquiterpene analogs...
  84. ncbi Zinc dyshomeostasis: a key modulator of neuronal injury
    Margherita Capasso
    Department of Neurology, CeSI-Center for Excellence on Aging, University G. D'Annunzio, Chieti, 66013, Italy
    J Alzheimers Dis 8:93-108; discussion 209-15. 2005
    ..Thus, multiple evidence suggest that modulation of intracellular and extracellular Zn2+ might be an important therapeutical target for the treatment of a vast array of neurological conditions ranging from stroke to Alzheimer's disease...
  85. ncbi Characterization of the hsp70 response in lymphoblasts from aged and centenarian subjects and differential effects of in vitro zinc supplementation
    Roberto Ambra
    National Institute for Food and Nutrition Research INRAN, Free radicals Res Group, 546 Via Ardeatina, I00178 Rome, Italy
    Exp Gerontol 39:1475-84. 2004
    ..Moreover, in vitro zinc supplementation had an age-dependent effect on hsp70 expression, indicating a role for this nutritionally important molecule and suggesting its involvement in cellular stress responses...
  86. ncbi Effect of improved zinc status on T helper cell activation and TH1/TH2 ratio in healthy elderly individuals
    Laura Kahmann
    Institute of Immunology, RWTH Aachen University Hospital, Pauwelsstr. 30, D-52074, Aachen, Germany
    Biogerontology 7:429-35. 2006
    ..These findings suggest that elderly individuals may benefit from moderate zinc supplementation due to improved immune response leading to reduced incidences of autoimmune diseases and infections...
  87. ncbi Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity
    Olga DelaRosa
    Immunology Unit, Department of Cellular Biology, Physiology and Immunology, , , s/n. 14071, Cordoba, Spain
    Biogerontology 7:471-81. 2006
    ....
  88. ncbi Zinc and ageing (ZINCAGE Project)
    Eugenio Mocchegiani
    Biogerontology 7:305-6. 2006
  89. ncbi Health status, blood and anthropometrical indices from Greek old and nonagenarian subjects
    Stavroula Kanoni
    Laboratory of Molecular Genetics, Department of Nutrition and Dietetics, Harokopio University of Athens, 70 El. Venizelou str, 17671, Kallithea-Athens, Greece
    Biogerontology 7:329-37. 2006
    ..Blood analysis confirmed the good health status of the elderly recruited as healthy, except for the high prevalence of obesity and hypercholesterolemia...
  90. ncbi Correlation between zinc status and immune function in the elderly
    Hajo Haase
    Institute of Immunology, University Hospital, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany
    Biogerontology 7:421-8. 2006
    ..This review summarizes the current literature about zinc supplementation in the elderly and thereby defines the rationale for the immunological part of the ZINCAGE project...
  91. ncbi Zn and Cu alteration in connection with astrocyte metallothionein I/II overexpression in the mouse brain upon physical stress
    Mariano Beltramini
    Department of Biology, University of Padova, Padova, Italy
    Glia 47:30-4. 2004
    ..Metallothionein I/II expression was compared with the immunopositivity of glial fibrillary acidic protein (GFAP). It is noteworthy that metallothioneins and GFAP are expressed in different types of astrocytes...
  92. ncbi Peripheral T lymphocyte changes in neonatal piglets: Relationship with growth hormone (GH), prolactin (PRL) and cortisol changes
    Paolo Borghetti
    Department of Animal Health, Faculty of Veterinary Medicine, University of Parma, Via del Taglio 8, 43100 Parma, Italy
    Vet Immunol Immunopathol 110:17-25. 2006
    ....
  93. ncbi Dysregulation of T-cell function in the elderly : scientific basis and clinical implications
    Tamas Fulop
    Immunology Program, Geriatric Division, Research Center on Aging, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Drugs Aging 22:589-603. 2005
    ..Considering the public health consequences of decreased immune competence in old age, strategies for immune response modulation are desirable to decrease the health burden for the elderly and improve their quality of life...
  94. ncbi Attachment security and immunity in healthy women
    Angelo Picardi
    Center of Epidemiology and Health Surveillance and Promotion, Italian National Institute of Health, Rome, Italy
    Psychosom Med 69:40-6. 2007
    ..Attachment security is associated with health and possibly autonomic and endocrine reactivity to stress, however the relationship between attachment style and immune function has not yet been investigated...
  95. ncbi Age-specific modulation of genes involved in lipid and cholesterol homeostasis by dietary zinc
    Dawn J Mazzatti
    Unilever Corporate Research, Sharnbrook, United Kingdom
    Rejuvenation Res 11:281-5. 2008
    ..Additionally, the individual genes affected and the extent of differential regulation varied with respect to donor age, suggesting that the age-related phenotype may alter zinc action...
  96. ncbi Zinc and inflammatory/immune response in aging
    Sonya Vasto
    Immunosenescence Unit, Department of Pathobiology and Biomedical Methodologies, Palermo University, Corso Tukory 211, 90134 Palermo, Italy
    Ann N Y Acad Sci 1100:111-22. 2007
    ....
  97. ncbi T cells and aging, January 2002 update
    Graham Pawelec
    University of Tubingen, Center for Medical Research, ZMF, Waldhornlestr 22, D 72072 Tubingen, Germany
    Front Biosci 7:d1056-183. 2002
    ....
  98. ncbi Simultaneous evaluation of circulating chemokine and cytokine profiles in elderly subjects by multiplex technology: relationship with zinc status
    Erminia Mariani
    Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, IOR, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Biogerontology 7:449-59. 2006
    ....
  99. ncbi Immunosupportive therapies in aging
    Tamas Fulop
    Research Center on Aging, Immunology Program, Geriatric Division, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Clin Interv Aging 2:33-54. 2007
    ..We will then discuss possible interventions that might one day become applicable in an appropriate ethical environment...
  100. ncbi Inflammation, genes and zinc in ageing and age-related diseases
    Sonya Vasto
    Department of Pathobiology and Biomedical Methodology, Palermo University, Corso Tukory 211, 90134, Palermo, Italy
    Biogerontology 7:315-27. 2006
    ..Therefore, Zn deficiency in individuals genetically predisposed to a dis-regulation of inflammation response, may play a crucial role, in causing adverse events and in reducing the probability of a successful aging...
  101. ncbi Inflammation, genes and zinc in Alzheimer's disease
    Sonya Vasto
    Department of Pathobiology and Biomedical Methodology, University of Palermo, Corso Tukory, 211, 90134 Palermo, Italy
    Brain Res Rev 58:96-105. 2008
    ..In particular, zinc availability may regulate mRNA cytokine expression, so influencing inflammatory network phenotypic expression...