Tiziana Casoli

Summary

Affiliation: Neurobiology of Aging Laboratory
Country: Italy

Publications

  1. ncbi request reprint Platelets in Alzheimer's disease-associated cellular senescence and inflammation
    Tiziana Casoli
    Neurobiology of Aging Centre, INRCA Scientific Technological Area, Via Birarelli 8, 60121 Ancona, Italy
    Curr Pharm Des 19:1727-38. 2013
  2. doi request reprint Dynamin binding protein gene expression and memory performance in aged rats
    Tiziana Casoli
    Neurobiology of Aging Laboratory, INRCA Scientific Technological Area, Ancona, Italy
    Neurobiol Aging 33:618.e15-9. 2012
  3. ncbi request reprint Release of beta-amyloid from high-density platelets: implications for Alzheimer's disease pathology
    Tiziana Casoli
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1096:170-8. 2007
  4. ncbi request reprint Platelet as a physiological model to investigate apoptotic mechanisms in Alzheimer beta-amyloid peptide production
    Tiziana Casoli
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Mech Ageing Dev 129:154-62. 2008
  5. ncbi request reprint Vitamin E deficiency and aging effect on expression levels of GAP-43 and MAP-2 in selected areas of the brain
    Tiziana Casoli
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1019:37-40. 2004
  6. ncbi request reprint GAP-43 mRNA detection by in situ hybridization, direct and indirect in situ RT-PCR in hippocampal and cerebellar tissue sections of adult rat brain
    Tiziana Casoli
    Neurobiology of Aging Center, N Masera INRCA Research Department, Via Birarelli 8, Ancona 60121, Italy
    Micron 34:415-22. 2003
  7. ncbi request reprint Effects of ethanol on GAP-43 levels in hippocampus and cerebellum of aged rats
    T Casoli
    Neurobiology of Aging Laboratory, N Masera I N R C A Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 973:313-6. 2002
  8. doi request reprint Peripheral inflammatory biomarkers of Alzheimer's disease: the role of platelets
    Tiziana Casoli
    Neurobiology of Aging Centre, Scientific Technological Area, INRCA, 60121 Ancona, Italy
    Biogerontology 11:627-33. 2010
  9. ncbi request reprint Beta-amyloid fragment 25-35 selectively damages platelets from patients with Alzheimer's disease
    Tiziana Casoli
    N Masera INRCA Research Department, Neurobiology of Aging Center, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 977:296-302. 2002
  10. ncbi request reprint Cellular distribution of GAP-43 mRNA in hippocampus and cerebellum of adult rat brain by in situ RT-PCR
    T Casoli
    Neurobiology of Aging, INRCA Research Department, Via Birarelli 8, Ancona AN 60121, Italy
    J Histochem Cytochem 49:1195-6. 2001

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Platelets in Alzheimer's disease-associated cellular senescence and inflammation
    Tiziana Casoli
    Neurobiology of Aging Centre, INRCA Scientific Technological Area, Via Birarelli 8, 60121 Ancona, Italy
    Curr Pharm Des 19:1727-38. 2013
    ..Nevertheless more research is needed to clarify all the different aspects and interactions of blood cells, vascular cells and their secretory products...
  2. doi request reprint Dynamin binding protein gene expression and memory performance in aged rats
    Tiziana Casoli
    Neurobiology of Aging Laboratory, INRCA Scientific Technological Area, Ancona, Italy
    Neurobiol Aging 33:618.e15-9. 2012
    ....
  3. ncbi request reprint Release of beta-amyloid from high-density platelets: implications for Alzheimer's disease pathology
    Tiziana Casoli
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1096:170-8. 2007
    ..Investigating the biochemical pathways triggering Abeta secretion in platelets might provide important information for developing tools to modulate this phenomenon in AD brains...
  4. ncbi request reprint Platelet as a physiological model to investigate apoptotic mechanisms in Alzheimer beta-amyloid peptide production
    Tiziana Casoli
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Mech Ageing Dev 129:154-62. 2008
    ..As a result, Abeta40 might be dangerous even before it becomes secreted rendering neurons highly vulnerable...
  5. ncbi request reprint Vitamin E deficiency and aging effect on expression levels of GAP-43 and MAP-2 in selected areas of the brain
    Tiziana Casoli
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1019:37-40. 2004
    ..These results suggest that oxidative stress and aging negatively affect neuroplasticity, showing different characteristics at the dendritic and axonal levels...
  6. ncbi request reprint GAP-43 mRNA detection by in situ hybridization, direct and indirect in situ RT-PCR in hippocampal and cerebellar tissue sections of adult rat brain
    Tiziana Casoli
    Neurobiology of Aging Center, N Masera INRCA Research Department, Via Birarelli 8, Ancona 60121, Italy
    Micron 34:415-22. 2003
    ..These data show that in normal rats GAP-43 mRNA is present in different cell populations of hippocampal formation, supporting the role of this protein in the ongoing processes of synaptic plasticity...
  7. ncbi request reprint Effects of ethanol on GAP-43 levels in hippocampus and cerebellum of aged rats
    T Casoli
    Neurobiology of Aging Laboratory, N Masera I N R C A Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 973:313-6. 2002
  8. doi request reprint Peripheral inflammatory biomarkers of Alzheimer's disease: the role of platelets
    Tiziana Casoli
    Neurobiology of Aging Centre, Scientific Technological Area, INRCA, 60121 Ancona, Italy
    Biogerontology 11:627-33. 2010
    ....
  9. ncbi request reprint Beta-amyloid fragment 25-35 selectively damages platelets from patients with Alzheimer's disease
    Tiziana Casoli
    N Masera INRCA Research Department, Neurobiology of Aging Center, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 977:296-302. 2002
    ..Since it is not possible to analyze directly the damaged neurons in AD, the study of peripheral blood cells, especially platelets, may be of great value for the investigation of the toxic effects of beta-amyloid on AD neuronal cells...
  10. ncbi request reprint Cellular distribution of GAP-43 mRNA in hippocampus and cerebellum of adult rat brain by in situ RT-PCR
    T Casoli
    Neurobiology of Aging, INRCA Research Department, Via Birarelli 8, Ancona AN 60121, Italy
    J Histochem Cytochem 49:1195-6. 2001
    ..Our data indicate that GAP-43 mRNA is widely distributed, suggesting that many cell types are potentially involved in synaptic plasticity events. (J Histochem Cytochem 49:1195-1196, 2001)..
  11. ncbi request reprint Age-related effects of moderate alcohol consumption on GAP-43 levels in rat hippocampus
    T Casoli
    Neurobiology of Ageing Laboratory, N Masera INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Mech Ageing Dev 122:1723-38. 2001
    ..Western blot analysis demonstrate that although there is a reduction of GAP-43 levels in hippocampus of aged rats, this structure retain a remarkable potential to compensate for ethanol toxicity during ageing...
  12. ncbi request reprint Preservation of mitochondrial volume homeostasis at the early stages of age-related synaptic deterioration
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1096:138-46. 2007
    ..However, the clear age-related preservation of the mitochondrial potential for structural dynamics may be interpreted as a reactive response to early signs of synaptic deterioration...
  13. ncbi request reprint Cytochrome oxidase activity in hippocampal synaptic mitochondria during aging: a quantitative cytochemical investigation
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1019:33-6. 2004
    ....
  14. doi request reprint Differences in gene expression in the hippocampus of aged rats are associated with better long-term memory performance in a passive avoidance test
    Giuseppina Di Stefano
    Neurobiology of Aging Laboratory, INRCA, Ancona, Italy
    Rejuvenation Res 13:224-8. 2010
    ..The differential expression of 14 of these genes was confirmed by real-time polymerase chain reaction...
  15. doi request reprint A ketogenic diet increases succinic dehydrogenase (SDH) activity and recovers age-related decrease in numeric density of SDH-positive mitochondria in cerebellar Purkinje cells of late-adult rats
    Marta Balietti
    Neurobiology of Aging Laboratory, INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Micron 41:143-8. 2010
    ..Given the central role of mitochondrial impairment in age-related physio-pathological changes of the brain, these findings may represent a starting point to examine novel potentialities for KDs...
  16. doi request reprint Ketogenic diets cause opposing changes in synaptic morphology in CA1 hippocampus and dentate gyrus of late-adult rats
    Marta Balietti
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    Rejuvenation Res 11:631-40. 2008
    ..This implies risks but also promising potentialities for their therapeutic use during aging...
  17. ncbi request reprint Testing mitochondrial metabolic competence by cytochrome oxidase preferential cytochemistry versus immunoreactivity of subunits I and IV
    Patrizia Fattoretti
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    Rejuvenation Res 9:215-8. 2006
    ....
  18. ncbi request reprint Alterations of synaptic turnover rate in aging may trigger senile plaque formation and neurodegeneration
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1096:128-37. 2007
    ..According to current literature data on synaptic structural dynamics, this decay may represent an early and subtle alteration able to trigger the development of senile plaques and neurodegenerative events...
  19. doi request reprint A ketogenic diet increases succinic dehydrogenase activity in aging cardiomyocytes
    Marta Balietti
    Neurobiology of Aging Laboratory, Italian National Research Centers on Aging, Ancona, Italy
    Ann N Y Acad Sci 1171:377-84. 2009
    ..These effects might counteract metabolic alterations leading to apoptosis-induced myocardial atrophy and failure during aging...
  20. pmc Impairments of synaptic plasticity in aged animals and in animal models of Alzheimer's disease
    Marta Balietti
    Neurobiology of Aging Laboratory, INRCA Scientific Technological Area, Ancona, Italy
    Rejuvenation Res 15:235-8. 2012
    ..We briefly review recent experimental evidence here...
  21. doi request reprint Effect of two medium chain triglycerides-supplemented diets on synaptic morphology in the cerebellar cortex of late-adult rats
    Marta Balietti
    Neurobiology of Aging Laboratory, INRCA, 60121 Ancona, Italy
    Microsc Res Tech 72:933-8. 2009
    ..Since GCL-CCx is more vulnerable to age than OML DG but less than SM CA1, present and previous results suggest that the effects of MCT-SDs in the aging brain critically depend on neuronal vulnerability to age, besides MCT percentage...
  22. ncbi request reprint Synaptic and mitochondrial morphometry provides structural correlates of successful brain aging
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1097:51-3. 2007
    ..Considering the functional significance of the above parameters, their substantial age-related constancy suggests that they may reasonably represent structural correlates of successful brain aging...
  23. doi request reprint Neuronal apoptosis in Alzheimer's disease: the role of age-related mitochondrial metabolic competence
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, Italian National Research Center on Aging, Ancona, Italy
    Ann N Y Acad Sci 1171:18-24. 2009
    ....
  24. doi request reprint Selective decline of the metabolic competence of oversized synaptic mitochondria in the old monkey cerebellum
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    Rejuvenation Res 11:387-91. 2008
    ....
  25. ncbi request reprint Early selective vulnerability of synapses and synaptic mitochondria in the hippocampal CA1 region of the Tg2576 mouse model of Alzheimer's disease
    Marta Balietti
    Neurobiology of Aging Centre, INRCA, Ancona, Italy Cellular Bioenergetics Laboratory, INRCA, Ancona, Italy
    J Alzheimers Dis 34:887-96. 2013
    ..Thus, morphological changes occurring at synaptic level in SMCA1 of 3 month-old Tg2576 mice might reflect a precocious vulnerability associated with a residual plastic reactivity which may slow down functional alterations...
  26. ncbi request reprint Experimental apoptosis provides clues about the role of mitochondrial changes in neuronal death
    Patrizia Fattoretti
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1090:79-88. 2006
    ..A better understanding of the mitochondrial role in neuronal apoptosis may suggest potential interventions to prevent the extensive nerve cell death typical of neurodegenerative diseases...
  27. ncbi request reprint Neuronal death versus synaptic pathology in Alzheimer's disease
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, 60121 Ancona, Italy
    Ann N Y Acad Sci 1010:635-8. 2003
    ..Our findings support the notion that synaptic loss represents per se a prominent and early damage affecting zones of the central nervous system reported to show a different vulnerability to age- and pathology-related changes...
  28. ncbi request reprint Brain aging: The zinc connection
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli, 60121 Ancona, Italy
    Exp Gerontol 43:389-93. 2008
    ....
  29. ncbi request reprint Decreased expression of glucose transport protein (Glut3) in aging and vitamin E deficiency
    Patrizia Fattoretti
    Neurobiology of Aging Laboratory, N Masera I N R C A Research Department, Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 973:293-6. 2002
  30. ncbi request reprint Level and distribution of microtubule-associated protein-2 (MAP2) as an index of dendritic structural dynamics
    Giuseppina Di Stefano
    INRCA Research Department, Neurobiology of Aging Laboratory, Ancona, Italy
    Rejuvenation Res 9:94-8. 2006
    ..These findings lend support to the many converging results on the higher vulnerability to aging of the CNS areas featuring higher plasticity...
  31. ncbi request reprint Synaptic pathology in the brain cortex of old monkeys as an early alteration in senile plaque formation
    Carlo Bertoni-Freddari
    INRCA Research Department, Neurobiology of Aging Laboratory, Ancona, Italy
    Rejuvenation Res 9:85-8. 2006
    ..6%). The present data support the hypothesis of an increased sensitivity to deterioration of TC synapses in aged monkeys, which might constitute a predisposing condition to the development of senile plaques...
  32. ncbi request reprint Cytochemical estimation of cytochrome oxidase activity as a morphofunctional mitochondrial check-up
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    Rejuvenation Res 9:202-6. 2006
    ....
  33. ncbi request reprint Synaptic and mitochondrial physiopathologic changes in the aging nervous system and the role of zinc ion homeostasis
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    Mech Ageing Dev 127:590-6. 2006
    ..Thus, a transient imbalance of free zinc ion concentration in the cytosol ([Zn2+]i) can be considered an unfavourable trigger of subtle mitochondrial damage and synaptic pathology...
  34. ncbi request reprint Decay of mitochondrial metabolic competence in the aging cerebellum
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, 60121 Ancona, Italy
    Ann N Y Acad Sci 1019:29-32. 2004
    ..0%). The present findings support that a marked dysfunction of small and medium-sized mitochondria contributes to the significant decay of energy metabolism currently reported in physiological aging...
  35. doi request reprint Decreased presence of perforated synapses in a triple-transgenic mouse model of Alzheimer's disease
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department, Ancona, Italy
    Rejuvenation Res 11:309-13. 2008
    ....
  36. ncbi request reprint Ketogenic diets: an historical antiepileptic therapy with promising potentialities for the aging brain
    Marta Balietti
    Neurobiology of Aging Laboratory, INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Ageing Res Rev 9:273-9. 2010
    ..Here we review clinical and experimental data on KDs treatments, focusing on their possible use during pathological aging. Proposed mechanisms of action are also reported and discussed...
  37. ncbi request reprint Reactive structural dynamics of synaptic mitochondria in ischemic delayed neuronal death
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, INRCA Research Department Via Birarelli 8, 60121 Ancona, Italy
    Ann N Y Acad Sci 1090:26-34. 2006
    ....
  38. ncbi request reprint Metallothionein isoforms (I+II and III) and interleukin-6 in the hippocampus of old rats: may their concomitant increments lead to neurodegeneration?
    Eugenio Mocchegiani
    Immunology Centre Section Nutrition, Immunity and Ageing, Res Dept INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Brain Res Bull 63:133-42. 2004
    ..As a consequence, compensatory phenomena between MT isoforms may not occur in the old hippocampus due to chronic stress-like condition elicited by high persistent levels of interleukin-6...
  39. ncbi request reprint In vitro apolipoprotein E protects human red blood cells against lysis induced by amyloid-beta (AP) fragment 25-35
    Luciano Galeazzi
    Laboratorio Analisi Chimico Cliniche, Microbiologiche e di Diagnostica Molecolare, INRCA IRCSS, Ancona, Italy
    Amyloid 9:103-7. 2002
    ..Such compounds would be candidate molecules for testing in neuronal systems...
  40. ncbi request reprint Effect of cognitive training on the expression of brain-derived neurotrophic factor in lymphocytes of mild cognitive impairment patients
    Tiziana Casoli
    1 Center for Neurobiology of Aging, INRCA IRCCS, Ancona, Italy
    Rejuvenation Res 17:235-8. 2014
    ..31) as compared to healthy subjects (fold change=0.86). It has been reported that in MCI there is an increase of BDNF serum levels, and our findings could indicate a positive effect of CT in restoring pre-disease levels of expression...
  41. ncbi request reprint Morphometry of E-PTA stained synapses at the periphery of pathological lesions
    Carlo Bertoni-Freddari
    Neurobiology of Aging Laboratory, N Masera Research Department, INRCA, Via Birarelli 8, 60121, Ancona, Italy
    Micron 33:447-51. 2002
    ..The same negative correlation between Nv and S has also been reported in physiological aging, and this suggests the active presence of age-related synaptic restructuring mechanisms in the nervous tissue surrounding a tumoral mass...
  42. ncbi request reprint Quantitative immunohistochemistry of glucose transport protein (Glut3) expression in the rat hippocampus during aging
    P Fattoretti
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, Ancona AN 60121, Italy
    J Histochem Cytochem 49:671-2. 2001
    ..Our findings therefore lend further support to the critical role of an impaired metabolism in age-related brain dysfunctions and disease.(J Histochem Cytochem 49:671-672, 2001)..
  43. ncbi request reprint Distribution of map2 in hippocampus and cerebellum of young and old rats by quantitative immunohistochemistry
    G Di Stefano
    Neurobiology of Aging Laboratory, INRCA Research Department, Via Birarelli 8, 60121, Ancona, Italy
    J Histochem Cytochem 49:1065-6. 2001
    ..These preliminary data suggest that in areas of the brain involved in memory acquisition and consolidation, MAP2-dependent neuroplasticity and structural integrity are significantly decreased in aging...
  44. ncbi request reprint Ethanol-induced decrease of the expression of glucose transport protein (Glut3) in the central nervous system as a predisposing condition to apoptosis: the effect of age
    P Fattoretti
    Neurobiology of Aging Laboratory, N Masera INRCA Research Department, 60121 Ancona, Italy
    Ann N Y Acad Sci 1010:500-3. 2003
    ..old ethanol-treated rats. These findings lend consistent support to the hypothesis that disturbances of glucose metabolism due to ethanol may constitute an unfavorable condition predisposing to neuronal death...
  45. ncbi request reprint Ultrastructure of phosphotungstic acid (PTA) positive deposits in the hippocampus of senile demented patients
    C Bertoni-Freddari
    Center for Surgical Research, INRCA Research Department, Ancona, Italy
    Boll Soc Ital Biol Sper 69:121-7. 1993
    ....
  46. doi request reprint One-month strawberry-rich anthocyanin supplementation ameliorates cardiovascular risk, oxidative stress markers and platelet activation in humans
    Jose M Alvarez-Suarez
    Dipartimento di Science Cliniche Specialistiche ed Odontostomatologiche, Facolta di Medicina, Universita Politecnica delle Marche, Ancona, Italy
    J Nutr Biochem 25:289-94. 2014
    ....
  47. doi request reprint Synaptic remodeling in hippocampal CA1 region of aged rats correlates with better memory performance in passive avoidance test
    Daniela Platano
    Department of Human and General Physiology, University of Bologna, Bologna, Italy
    Rejuvenation Res 11:341-8. 2008
    ..Present findings indicate that maintenance of synaptic plastic reactivity during aging is a critical requirement for preserving long-term memory consolidation...