M Zaccarelli

Summary

Affiliation: National Institute for Infectious Diseases
Country: Italy

Publications

  1. ncbi request reprint Q151M-mediated multinucleoside resistance: prevalence, risk factors, and response to salvage therapy
    Mauro Zaccarelli
    Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Rome, Italy
    Clin Infect Dis 38:433-7. 2004
  2. pmc Changes in regular condom use among immigrant transsexuals attending a counselling and testing reference site in central Rome: a 12 year study
    M Zaccarelli
    National Institute for Infectious Diseases Lazzaro Spallanzani, Via Portuense 292, 00149 Rome, Italy
    Sex Transm Infect 80:541-5. 2004
  3. ncbi request reprint The challenge of antiretroviral-drug-resistant HIV: is there any possible clinical advantage?
    Mauro Zaccarelli
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    Curr HIV Res 2:283-92. 2004
  4. ncbi request reprint Multiple drug class-wide resistance associated with poorer survival after treatment failure in a cohort of HIV-infected patients
    Mauro Zaccarelli
    Clinical Department bLaboratory of Antiviral Drug Monitoring, National Institute of Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy
    AIDS 19:1081-9. 2005
  5. ncbi request reprint The V118I mutation as a marker of advanced HIV infection and disease progression
    Mauro Zaccarelli
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    Antivir Ther 12:163-8. 2007
  6. ncbi request reprint Evidence of dual sexual transmission of multi-resistant HIV with two years persistence of resistance to NRTI and NNRTI: a case report
    M Zaccarelli
    National Institute for Infectious Diseases Lazzaro Spallanzani, Via Portuense 292, 00149, Rome, Italy
    Infection 36:178-80. 2008
  7. ncbi request reprint Historical resistance profile helps to predict salvage failure
    Mauro Zaccarelli
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    Antivir Ther 14:285-91. 2009
  8. doi request reprint Effect of suppressing HIV viremia on the HIV progression of patients undergoing a genotype resistance test after treatment failure
    M Zaccarelli
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, Via Portuense 292, 00149, Rome, Italy
    Infection 37:203-9. 2009
  9. ncbi request reprint HIV infection among foreign transsexual sex workers in Rome: prevalence, behavior patterns, and seroconversion rates
    L Spizzichino
    Unita Operativa AIDS, Azienda Sanitaria Locale Roma E ASL RME, Rome, Italy
    Sex Transm Dis 28:405-11. 2001
  10. ncbi request reprint Response to highly active antiretroviral therapy according to duration of HIV infection
    P Pezzotti
    Reparto AIDS e MST, Istituto Superiore di Sanita, Rome, Italy
    J Acquir Immune Defic Syndr 26:473-9. 2001

Detail Information

Publications45

  1. ncbi request reprint Q151M-mediated multinucleoside resistance: prevalence, risk factors, and response to salvage therapy
    Mauro Zaccarelli
    Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Rome, Italy
    Clin Infect Dis 38:433-7. 2004
    ..A full reversion of the Q151M mutation was observed in 5 of 5 patients who underwent treatment interruption after GRT. The reversion was followed by a response to salvage therapy in 4 (80%) of 5 patients...
  2. pmc Changes in regular condom use among immigrant transsexuals attending a counselling and testing reference site in central Rome: a 12 year study
    M Zaccarelli
    National Institute for Infectious Diseases Lazzaro Spallanzani, Via Portuense 292, 00149 Rome, Italy
    Sex Transm Infect 80:541-5. 2004
    ..To analyse data from male to female transsexuals attending between 1992 and 2003 an outpatient clinic considered the main HIV counselling and testing site in Rome for foreign people...
  3. ncbi request reprint The challenge of antiretroviral-drug-resistant HIV: is there any possible clinical advantage?
    Mauro Zaccarelli
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    Curr HIV Res 2:283-92. 2004
    ..Phenotypic hypersusceptibility has been demonstrated for all three drug classes. Particularly, NNRTI hypersusceptibility, associated with NRTI mutations, is analyzed and discussed...
  4. ncbi request reprint Multiple drug class-wide resistance associated with poorer survival after treatment failure in a cohort of HIV-infected patients
    Mauro Zaccarelli
    Clinical Department bLaboratory of Antiviral Drug Monitoring, National Institute of Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy
    AIDS 19:1081-9. 2005
    ..To evaluate the effect of drug class-wide resistance (CWR) on survival in HIV-infected individuals who underwent genotypic resistance test after antiretroviral failure...
  5. ncbi request reprint The V118I mutation as a marker of advanced HIV infection and disease progression
    Mauro Zaccarelli
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    Antivir Ther 12:163-8. 2007
    ..We focused on the V1181 mutation in order to evaluate factors associated with its detection and its relationship with HIV progression...
  6. ncbi request reprint Evidence of dual sexual transmission of multi-resistant HIV with two years persistence of resistance to NRTI and NNRTI: a case report
    M Zaccarelli
    National Institute for Infectious Diseases Lazzaro Spallanzani, Via Portuense 292, 00149, Rome, Italy
    Infection 36:178-80. 2008
    ..Data also suggest that mutations related to NRTI and NNRTI resistance may persist for a long time in naive patients, over 2 years in the present case report...
  7. ncbi request reprint Historical resistance profile helps to predict salvage failure
    Mauro Zaccarelli
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    Antivir Ther 14:285-91. 2009
    ....
  8. doi request reprint Effect of suppressing HIV viremia on the HIV progression of patients undergoing a genotype resistance test after treatment failure
    M Zaccarelli
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, Via Portuense 292, 00149, Rome, Italy
    Infection 37:203-9. 2009
    ..To assess the role of viral suppression on clinical progression following a genotypic resistance test (GRT), we have examined a database on patients failing to respond to combined antiretroviral therapy (cART)...
  9. ncbi request reprint HIV infection among foreign transsexual sex workers in Rome: prevalence, behavior patterns, and seroconversion rates
    L Spizzichino
    Unita Operativa AIDS, Azienda Sanitaria Locale Roma E ASL RME, Rome, Italy
    Sex Transm Dis 28:405-11. 2001
    ..The Azienda Sanitaria Locale Roma E (ASL-RME) outpatient clinic is the main reference center in Rome for HIV testing of foreign people...
  10. ncbi request reprint Response to highly active antiretroviral therapy according to duration of HIV infection
    P Pezzotti
    Reparto AIDS e MST, Istituto Superiore di Sanita, Rome, Italy
    J Acquir Immune Defic Syndr 26:473-9. 2001
    ..To evaluate whether duration of HIV-1 infection influences the response to highly active antiretroviral therapy (HAART)...
  11. ncbi request reprint Incidence and consequences of pregnancy in women with known duration of HIV infection. Italian Seroconversion Study Group
    M B Alliegro
    Istituto Superiore di Sanita, Laboratory of Epidemiology and Biostatistics, Centro Operativo AIDS, Rome, Italy
    Arch Intern Med 157:2585-90. 1997
    ..The increasing incidence of human immunodeficiency virus (HIV) infection in women of childbearing age led us to evaluate whether pregnancy affects the natural history of this disease...
  12. ncbi request reprint Syphilis serology among transvestite prostitutes attending an HIV unit in Rome, Italy
    P Gattari
    AIDS Unit, S Spirito Hospital, Rome, Italy
    Eur J Epidemiol 10:683-6. 1994
    ..No overall correlation was evident between TPHA positivity and anti-HIV positivity, while SPHA-IgM positivity was found to be higher among anti-HIV-negative subjects.(ABSTRACT TRUNCATED AT 250 WORDS)..
  13. ncbi request reprint Female sex and the use of anti-allergic agents increase the risk of developing cutaneous rash associated with nevirapine therapy
    A Antinori
    National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy
    AIDS 15:1579-81. 2001
    ..Women receiving glucocorticoids had a 3 month cumulative probability of rash of 0.41...
  14. doi request reprint Favourable evolution of virological and immunological profiles in treated and untreated patients in Italy in the period 1998-2008
    M C F Prosperi
    Clinic of Infectious Diseases, Catholic University of Sacred Heart, Rome, Italy
    HIV Med 12:174-82. 2011
    ....
  15. doi request reprint Rate of CD4+ cell count increase over periods of viral load suppression: relationship with the number of previous virological failures
    Maria Paola Trotta
    Clinical Department, National Institute for Infectious Diseases L Spallanzani, Roma, Italy
    Clin Infect Dis 51:456-64. 2010
    ..Although the kinetics of CD4(+) cell counts have been extensively studied in antiretroviral-naive HIV-infected patients, data on individuals who have failed combination antiretroviral therapy (cART) are lacking...
  16. doi request reprint Self-reported sexual dysfunction is frequent among HIV-infected persons and is associated with suboptimal adherence to antiretrovirals
    Maria Paola Trotta
    Istituto Nazionale per le Malattie Infettive, L Spallanzani IRCCS, Rome, Italy
    AIDS Patient Care STDS 22:291-9. 2008
    ..44; 95% CI 1.30-9.08). In conclusion, patients' perceived SD represents a relevant problem for HIV-infected persons treated with antiretrovirals and is strongly associated with suboptimal HAART adherence...
  17. ncbi request reprint Factors related to virologic failure among HIV-positive injecting drug users treated with combination antiretroviral therapy including two nucleoside reverse transcriptase inhibitors and nevirapine
    M Zaccarelli
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    AIDS Patient Care STDS 16:67-73. 2002
    ..Our results show that continuing injecting drug use and treatment breaks are the main factors that can lead to treatment failure in IDUs and easily to NNRTI class resistance...
  18. doi request reprint Incidence of malignancies in HIV-infected patients and prognostic role of current CD4 cell count: evidence from a large Italian cohort study
    M C F Prosperi
    Istituto di Clinica delle Malattie Infettive, Universita Cattolica del Sacro Cuore, Rome, Italy
    Clin Infect Dis 50:1316-21. 2010
    ..9-3.1 cases per 1000 person-years of follow-up), respectively. Lower current CD4 cell count was an independent predictor of developing malignancies, with the association being stronger for ADM than for NADM...
  19. ncbi request reprint Dynamics of viral load in plasma and HIV DNA in lymphocytes during highly active antiretroviral therapy (HAART): high viral burden in macrophages after 1 year of treatment
    A R Garbuglia
    Center of Virology, Spallanzani Hospital, IRCCS, Rome, Italy
    J Chemother 13:188-94. 2001
    ..The data indicate that a durable reservoir of virus is still present in both lymphocytes and monocytes, even after long-lasting HAART treatment...
  20. pmc No significant association between patient self-reported non-adherence to antiretrovirals and HIV-tropism: a preliminary analysis
    A Ammassari
    INMI L Spallanzani, IRCCS, Rome, Italy
    J Int AIDS Soc 15:18090. 2012
    ..It is possible that patient self-reported adherence is not able to capture nonadherence behaviors that underlie more pronounced viral replication which may be necessary for tropism switch...
  21. ncbi request reprint Safety and efficacy of regimens containing emtricitabine in HIV-infected patients taking highly active antiretroviral therapy
    Patrizia Marconi
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Roma, Italy
    New Microbiol 29:169-75. 2006
    ..Efficacy analysis in viremic patients showed that 6 months-probability of virologic success during treatment with FTC was 74.7%. Our preliminary observation show that FTC-regimens seems effective and tolerable in real practice...
  22. ncbi request reprint Lopinavir/ritonavir or efavirenz plus two nucleoside analogues as first-line antiretroviral therapy: a non-randomized comparison
    Andrea De Luca
    Institute of Clinical Infectious Diseases, Catholic University of the Sacred Heart, Rome, Italy
    Antivir Ther 11:609-18. 2006
    ..A multi-cohort prospective observational comparative study was performed...
  23. ncbi request reprint Drug-class-wide resistance to antiretrovirals in HIV-infected patients failing therapy: prevalence, risk factors and virological outcome
    Valerio Tozzi
    National Institute for Infectious Diseases Lazzaro Spallanzani, Via Portuense 292, 00149 Rome, Italy
    Antivir Ther 11:553-60. 2006
    ..Drug-class-wide resistance (DCWR) to antiretrovirals substantially reduces treatment options...
  24. ncbi request reprint Cross-resistance among nonnucleoside reverse transcriptase inhibitors limits recycling efavirenz after nevirapine failure
    Andrea Antinori
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, 00149 Rome, Italy
    AIDS Res Hum Retroviruses 18:835-8. 2002
    ..No virological response was observed in six patients harboring a single Y181C/I mutation. On the basis of the present data, sequential use of NNRTIs should be avoided in the management of treatment failure...
  25. ncbi request reprint Optimal timing and best antiretroviral regimen in treatment-naive HIV-infected individuals with advanced disease
    Christian Manzardo
    Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    J Acquir Immune Defic Syndr 46:S9-18. 2007
    ....
  26. doi request reprint Specific enfuvirtide-associated mutational pathways in HIV-1 Gp41 are significantly correlated with an increase in CD4(+) cell count, despite virological failure
    Valentina Svicher
    Department of Experimental Medicine, University of Tor Vergata Rome, Italy
    J Infect Dis 197:1408-18. 2008
    ..We investigated the correlation of enfuvirtide (ENF)-associated gp41 mutational clusters with viroimmunological parameters, as well as the potential underlying mechanisms...
  27. ncbi request reprint Mutations in HIV-1 reverse transcriptase potentially associated with hypersusceptibility to nonnucleoside reverse-transcriptase inhibitors: effect on response to efavirenz-based therapy in an urban observational cohort
    Valerio Tozzi
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    J Infect Dis 189:1688-95. 2004
    ..We evaluated the effect of RT mutations associated with hypersusceptibility to NNRTIs on the response to efavirenz-based therapy...
  28. ncbi request reprint Reduction of HIV-1 viral load in saliva by indinavir-containing antiretroviral regimen
    Giuseppina Liuzzi
    AIDS 16:503-4. 2002
  29. ncbi request reprint Specific mutations in HIV-1 gp41 are associated with immunological success in HIV-1-infected patients receiving enfuvirtide treatment
    Stefano Aquaro
    Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, Rome, Italy
    J Antimicrob Chemother 58:714-22. 2006
    ..To investigate gp41 variability and correlation with viro-immunological parameters in 54 HIV-1-infected patients receiving enfuvirtide added as single active drug to a failing regimen...
  30. ncbi request reprint Temporal characterization of drug resistance associated mutations in HIV-1 protease and reverse transcriptase in patients failing antiretroviral therapy
    Maria Mercedes Santoro
    Department of Experimental Medicine, Tor Vergata University of Rome, Italy
    New Microbiol 29:89-100. 2006
    ....
  31. ncbi request reprint Antiviral efficacy and genotypic resistance patterns of combination therapy with stavudine/tenofovir in highly active antiretroviral therapy experienced patients
    Andrea Antinori
    National Institute for Infectious Diseases L Spallanzani IRCCS, Roma
    Antivir Ther 11:233-43. 2006
    ..To evaluate antiviral efficacy of stavudine/tenofovir (d4T/TDF) backbone combination in late-line antiretroviral therapy, and to assess clinical and virological determinants of treatment success...
  32. ncbi request reprint Adherence to highly active antiretroviral therapy is better in patients receiving non-nucleoside reverse transcriptase inhibitor-containing regimens than in those receiving protease inhibitor-containing regimens
    Maria Paola Trotta
    Istituto Nazionale per le Malattie Infettive, L Spallanzani IRCCS, Rome, Italy
    AIDS 17:1099-102. 2003
    ..By contrast, younger age, self-report of active drug use, fatigue or vomiting negatively affected adherence. Self-reported sexual dysfunction was significantly associated with non-adherence only in PI-treated individuals...
  33. ncbi request reprint The effect of number of mutations and of drug-class sparing on virological response to salvage genotype-guided antiretroviral therapy
    Bruno Christian Ciancio
    Clinical Department and Laboratory of Antiviral and Antineoplastic Drug Monitoring, National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Roma, Italy
    Antivir Ther 8:611-6. 2003
    ..To assess on longitudinal data the impact of number of drug-associated mutations at genotype resistance testing (GRT) and history of previous exposure to antiretrovirals on the virological response to genotype-guided antiretroviral therapy...
  34. ncbi request reprint Dynamics of viral load rebound in plasma and semen after stopping effective antiretroviral therapy
    Giuseppina Liuzzi
    National Institute for Infectious Diseases L Spallanzani, Rome, Italy
    AIDS 17:1089-92. 2003
    ..The reintroduction of therapy was followed by an overall decrease in HIV-RNA in plasma and semen. One to 2 months after restarting treatment, four out of seven patients showed undetectable HIV-RNA in semen...
  35. ncbi request reprint Relative prognostic value of self-reported adherence and plasma NNRTI/PI concentrations to predict virological rebound in patients initially responding to HAART
    Andrea Antinori
    Istituto Nazionale per le Malattie Infettive, L Spallanzani IRCCS, Roma, Italy
    Antivir Ther 9:291-6. 2004
    ..6%) experienced virological rebound by 96 weeks. Both self-reported non-adherence and sub-optimal concentration were independently associated with a higher risk of virological rebound...
  36. ncbi request reprint Treatment-related factors and highly active antiretroviral therapy adherence
    Maria Paola Trotta
    Istituto Nazionale per le Malattie Infettive, L Spallanzani IRCCS, Roma, Italy
    J Acquir Immune Defic Syndr 31:S128-31. 2002
    ....
  37. ncbi request reprint Differences between semen and plasma of nucleoside reverse transcriptase resistance mutations in HIV-infected patients, using a rapid assay
    Giuseppina Liuzzi
    National Institute for Infectious Diseases, L Spallanzani IRCCS, Rome, Italy
    In Vivo 18:509-12. 2004
    ..Our data reinforce the evidence that, regarding HIV replication, the male genital tract must be considered as a separate compartment from the plasma...
  38. ncbi request reprint Using a database of HIV patients undergoing genotypic resistance test after HAART failure to understand the dynamics of M184V mutation
    Mauro Zaccarelli
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    Antivir Ther 8:51-6. 2003
    ..M184V/I mutation is associated with high-level phenotypic resistance to lamivudine (3TC). The aim of the present analysis was to correlate the time of appearance/disappearance of M184V/I with duration of 3TC treatment...
  39. ncbi request reprint High incidence of tuberculin skin test conversion among HIV-infected individuals who have a favourable immunological response to highly active antiretroviral therapy
    Enrico Girardi
    Dipartimento di Epidemiologia and Dipartimento Clinico, Istituto Nazionale per le Malattie Infettive L Spallanzani, IRCCS, Rome, Italy
    AIDS 16:1976-9. 2002
  40. ncbi request reprint The effect of hepatitis C on progression to AIDS before and after highly active antiretroviral therapy
    Maria Dorrucci
    Centro Operativo AIDS, Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Rome, Italy
    AIDS 18:2313-8. 2004
    ..To assess the effect of infection with hepatitis C virus (HCV) on the progression of human immunodeficiency virus (HIV) disease, before and after the introduction of highly active antiretroviral therapy (HAART)...
  41. ncbi request reprint Gynecomastia in male HIV patients MRI and US findings
    Vincenzo SchininĂ 
    Department of Radiology, National Institute for Infectious Diseases Lazzaro Spallanzani Via Portuense 292, Rome 00149, Italy
    Clin Imaging 26:309-13. 2002
    ..To evaluate the role of MRI and sonography in differential diagnosis between gynecomastia and lipomastia in adult male HIV patients treated with high-activity antiretroviral therapy (HAART) for guide management...
  42. ncbi request reprint Prevalence and risk factors for human immunodeficiency virus-associated neurocognitive impairment, 1996 to 2002: results from an urban observational cohort
    Valerio Tozzi
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    J Neurovirol 11:265-73. 2005
    ....
  43. ncbi request reprint Clinical and genotypic correlates of mutation K65R in HIV-infected patients failing regimens not including tenofovir
    Maria Paola Trotta
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy
    J Med Virol 78:535-41. 2006
    ..However, exposure to abacavir and/or efavirenz, presence of Q151M and/or L100I, and prior AIDS may favor the selection of this mutation. Conversely, long 3TC exposure, and the presence of M184V or NAMs seem to be protective...
  44. ncbi request reprint Lipodystrophy is associated with a low rate of treatment failure in HIV-positive patients switched to atazanavir
    Mauro Zaccarelli
    J Acquir Immune Defic Syndr 39:125-6. 2005
  45. pmc Patient-reported and physician-estimated adherence to HAART: social and clinic center-related factors are associated with discordance
    Rita Murri
    Clinica delle Malattie Infettive, Universita Cattolica del S Cuore, 00168 Rome, Italy
    J Gen Intern Med 19:1104-10. 2004
    ..To evaluate the rate of discordance between patients and physicians on adherence to highly active antiretroviral therapy (HAART) and identify factors related to discordance in these two assessments...