L Varesco

Summary

Affiliation: National Cancer Research Institute
Country: Italy

Publications

  1. ncbi request reprint Familial adenomatous polyposis: genetics and epidemiology
    L Varesco
    Center for Hereditary Tumours, National Institute for Cancer Research, Genoa, Italy
    Tech Coloproctol 8:s305-8. 2004
  2. pmc A silent mutation in exon 14 of the APC gene is associated with exon skipping in a FAP family
    M Montera
    J Med Genet 38:863-7. 2001
  3. ncbi request reprint Genotype and phenotype factors as determinants of desmoid tumors in patients with familial adenomatous polyposis
    L Bertario
    Department of Surgery, National Cancer Institute, Milan, Italy
    Int J Cancer 95:102-7. 2001
  4. ncbi request reprint Phenotype-genotype correlations in an extended family with adenomatosis coli and an unusual APC gene mutation
    M Ponz de Leon
    Dipartimento di Medicina Interna, , Modena, Italy
    Dis Colon Rectum 44:1597-604. 2001
  5. ncbi request reprint Multiple approach to the exploration of genotype-phenotype correlations in familial adenomatous polyposis
    L Bertario
    Division of Predictive and Preventive Medicine, Department of Experimental Oncology, National Cancer Institute, Via Venezian 1 20133 Milan, Italy
    J Clin Oncol 21:1698-707. 2003
  6. ncbi request reprint Attenuated familial adenomatous polyposis and Muir-Torre syndrome linked to compound biallelic constitutional MYH gene mutations
    G Ponti
    Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
    Clin Genet 68:442-7. 2005
  7. ncbi request reprint The NM23 gene maps to human chromosome band 17q22 and shows a restriction fragment length polymorphism with BglII
    L Varesco
    Institute of Pathological Anatomy and Histology, University of Pisa, Italy
    Genes Chromosomes Cancer 4:84-8. 1992
  8. ncbi request reprint Different expressivity of two adjacent mutations of the APC gene
    S Presciuttini
    Italian Polyposis Registry, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan
    Tumori 85:28-31. 1999
  9. pmc CpG island clones from a deletion encompassing the gene for adenomatous polyposis coli
    L Varesco
    Molecular Analysis of Mammalian Mutation Laboratory, Imperial Cancer Research Fund, Lincolns Inn Fields, London, United Kingdom
    Proc Natl Acad Sci U S A 86:10118-22. 1989
  10. ncbi request reprint Impact of surgery on the development of duodenal cancer in patients with familial adenomatous polyposis
    G Biasco
    Institute of Haemathology and Medical Oncology L and A Seràgnoli, Via Massarenti 9, 40138, Bologna, Italy
    Dis Colon Rectum 49:1860-6. 2006

Collaborators

  • G Ponti
  • L Bertario
  • V Gismondi
  • M Ponz de Leon
  • P Sala
  • G Biasco
  • R Sassatelli
  • P Radice
  • A Russo
  • M Giarola
  • M Montera
  • S Presciuttini
  • L Camellini
  • E Nobili
  • M Risio
  • G Brandi
  • G Poggioli
  • G Bedogni
  • C Calabrese
  • T Venesio
  • M A Pantaleo
  • G Bertoni
  • A de Vivo
  • G Di Febo
  • M Pierotti
  • P Mondini
  • P Spinelli
  • F D'Amico
  • N Resta
  • L Roncucci
  • M De Rosa
  • P Izzo
  • P Benatti
  • C Marchese
  • C Di Gregorio
  • M I Scarano
  • C Mareni
  • M A Pierotti
  • A Stella
  • F Piaggio
  • A Percesepe
  • M Eboli
  • G B Rossi
  • G Guanti
  • F Mosca
  • F Molina
  • C Caroti-Ghelli
  • C Rossetti
  • E Scarcello
  • J Groden

Detail Information

Publications10

  1. ncbi request reprint Familial adenomatous polyposis: genetics and epidemiology
    L Varesco
    Center for Hereditary Tumours, National Institute for Cancer Research, Genoa, Italy
    Tech Coloproctol 8:s305-8. 2004
    ..Also, genetic testing may be of help in the diagnosis of atypical adenomatous polyposis cases and in the clinical management of affected individuals...
  2. pmc A silent mutation in exon 14 of the APC gene is associated with exon skipping in a FAP family
    M Montera
    J Med Genet 38:863-7. 2001
  3. ncbi request reprint Genotype and phenotype factors as determinants of desmoid tumors in patients with familial adenomatous polyposis
    L Bertario
    Department of Surgery, National Cancer Institute, Milan, Italy
    Int J Cancer 95:102-7. 2001
    ..9; 95% CI 1.1-3.4). Our results indicate that integrating genetic and clinical data is helpful in defining subgroups of patients at higher risk for desmoids, who may benefit from specific prevention programs...
  4. ncbi request reprint Phenotype-genotype correlations in an extended family with adenomatosis coli and an unusual APC gene mutation
    M Ponz de Leon
    Dipartimento di Medicina Interna, , Modena, Italy
    Dis Colon Rectum 44:1597-604. 2001
    ..The study may help to understand the biologic mechanisms of genotype-phenotype correlations in adenomatosis coli...
  5. ncbi request reprint Multiple approach to the exploration of genotype-phenotype correlations in familial adenomatous polyposis
    L Bertario
    Division of Predictive and Preventive Medicine, Department of Experimental Oncology, National Cancer Institute, Via Venezian 1 20133 Milan, Italy
    J Clin Oncol 21:1698-707. 2003
    ..We analyzed a large series of FAP patients to identify associations among major clinical manifestations and to correlate the mutation site with specific disease manifestations...
  6. ncbi request reprint Attenuated familial adenomatous polyposis and Muir-Torre syndrome linked to compound biallelic constitutional MYH gene mutations
    G Ponti
    Department of Internal Medicine, University of Modena and Reggio Emilia, Modena, Italy
    Clin Genet 68:442-7. 2005
    ..These findings suggest that patients with MTS phenotype that include colonic polyposis should be screened for MYH gene mutations...
  7. ncbi request reprint The NM23 gene maps to human chromosome band 17q22 and shows a restriction fragment length polymorphism with BglII
    L Varesco
    Institute of Pathological Anatomy and Histology, University of Pisa, Italy
    Genes Chromosomes Cancer 4:84-8. 1992
    ..The mapping of NM23-Hl by panels of rodent-human somatic cell hybrids and in situ hybridization showed that the gene is located in human chromosome band 17q22. A two-allele polymorphism with BglII was demonstrated...
  8. ncbi request reprint Different expressivity of two adjacent mutations of the APC gene
    S Presciuttini
    Italian Polyposis Registry, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan
    Tumori 85:28-31. 1999
    ..1 for family B (P < 0.001). CONCLUSIONS: There is significant variation of expressivity (allelic heterogeneity) in FAP between two mutations separated by only eight codons, located at the 5' extremity of APC gene exon 15...
  9. pmc CpG island clones from a deletion encompassing the gene for adenomatous polyposis coli
    L Varesco
    Molecular Analysis of Mammalian Mutation Laboratory, Imperial Cancer Research Fund, Lincolns Inn Fields, London, United Kingdom
    Proc Natl Acad Sci U S A 86:10118-22. 1989
    ..5- to 2-megabase BssHII fragments purified by pulsed-field gel electrophoresis. Three markers are described that map within the deletions and must therefore be close to the APC gene...
  10. ncbi request reprint Impact of surgery on the development of duodenal cancer in patients with familial adenomatous polyposis
    G Biasco
    Institute of Haemathology and Medical Oncology L and A Seràgnoli, Via Massarenti 9, 40138, Bologna, Italy
    Dis Colon Rectum 49:1860-6. 2006
    ..We proposed to determine the frequency, natural history, cumulative risk, and risk factors of the precancerous duodenal lesions in a series of patients diagnosed in northern Italy...