Alessandra Sacchi

Summary

Affiliation: National Institute for Infectious Diseases
Country: Italy

Publications

  1. doi request reprint The basal activation state of DC subsets correlates with anti-HCV treatment outcome in HCV/HIV co-infected patients
    Alessandra Sacchi
    Laboratory of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy
    Clin Immunol 138:178-86. 2011
  2. ncbi request reprint Differentiation of monocytes into CD1a- dendritic cells correlates with disease progression in HIV-infected patients
    Alessandra Sacchi
    National Institute for Infectious Disease L Spallanzani IRCCS, Rome, Italy
    J Acquir Immune Defic Syndr 46:519-28. 2007
  3. doi request reprint Zoledronic acid and interleukin-2 treatment improves immunocompetence in HIV-infected persons by activating Vgamma9Vdelta2 T cells
    Fabrizio Poccia
    Laboratory of Cellular Immunology, National Institute for Infectious Diseases, LazzaroSpallanzani I R C C S, Rome 00149, Italy
    AIDS 23:555-65. 2009
  4. ncbi request reprint Activated V gamma 9V delta 2 T cells trigger granulocyte functions via MCP-2 release
    Chiara Agrati
    National Institute for Infectious Diseases Lazzaro Spallanzani Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    J Immunol 182:522-9. 2009
  5. doi request reprint Chronic HIV-infected patients show an impaired dendritic cells differentiation of bone marrow CD34⁺ cells
    Veronica Bordoni
    Laboratory of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani I R C C S, Rome, Italy Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani I R C C S, Rome, Italy Department of Haematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy and Virology Laboratory, National Institute for Infectious Diseases Lazzaro Spallanzani I R C C S, Rome, Italy
    J Acquir Immune Defic Syndr 64:342-4. 2013
  6. ncbi request reprint Innate gamma/delta T-cells during HIV infection: Terra relatively Incognita in novel vaccination strategies?
    Chiara Agrati
    Laboratory of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy
    AIDS Rev 13:3-12. 2011
  7. doi request reprint CD3zeta down-modulation may explain Vgamma9Vdelta2 T lymphocyte anergy in HIV-infected patients
    Alessandra Sacchi
    Laboratory of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    J Infect Dis 199:432-6. 2009
  8. pmc Interferon-α improves phosphoantigen-induced Vγ9Vδ2 T-cells interferon-γ production during chronic HCV infection
    Eleonora Cimini
    Cellular Immunology Laboratory, National Institute for Infectious Diseases Lazzaro Spallanzani I R C C S, Rome, Italy
    PLoS ONE 7:e37014. 2012
  9. doi request reprint GB-virus type C effect on HIV infection, interferon system, and dendritric cells
    Alessandra Sacchi
    National Institute for Infectious Diseases L Spallanzani, Rome, Italy
    Arch Med Res 39:362-3. 2008
  10. doi request reprint Cutting edge: TGF-beta1 and IL-15 Induce FOXP3+ gammadelta regulatory T cells in the presence of antigen stimulation
    Rita Casetti
    Laboratory of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani Instituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    J Immunol 183:3574-7. 2009

Collaborators

Detail Information

Publications19

  1. doi request reprint The basal activation state of DC subsets correlates with anti-HCV treatment outcome in HCV/HIV co-infected patients
    Alessandra Sacchi
    Laboratory of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy
    Clin Immunol 138:178-86. 2011
    ..These findings could be helpful to better understand the mediators of IFN-α action in HCV+/HIV+ patients and to explore possible exploitation of this knowledge to improve therapeutic response...
  2. ncbi request reprint Differentiation of monocytes into CD1a- dendritic cells correlates with disease progression in HIV-infected patients
    Alessandra Sacchi
    National Institute for Infectious Disease L Spallanzani IRCCS, Rome, Italy
    J Acquir Immune Defic Syndr 46:519-28. 2007
    ..These results suggest that the differentiation of monocytes into CD1a* DCs may be a phenotypic marker associated with progression of the disease...
  3. doi request reprint Zoledronic acid and interleukin-2 treatment improves immunocompetence in HIV-infected persons by activating Vgamma9Vdelta2 T cells
    Fabrizio Poccia
    Laboratory of Cellular Immunology, National Institute for Infectious Diseases, LazzaroSpallanzani I R C C S, Rome 00149, Italy
    AIDS 23:555-65. 2009
    ....
  4. ncbi request reprint Activated V gamma 9V delta 2 T cells trigger granulocyte functions via MCP-2 release
    Chiara Agrati
    National Institute for Infectious Diseases Lazzaro Spallanzani Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    J Immunol 182:522-9. 2009
    ....
  5. doi request reprint Chronic HIV-infected patients show an impaired dendritic cells differentiation of bone marrow CD34⁺ cells
    Veronica Bordoni
    Laboratory of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani I R C C S, Rome, Italy Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani I R C C S, Rome, Italy Department of Haematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy and Virology Laboratory, National Institute for Infectious Diseases Lazzaro Spallanzani I R C C S, Rome, Italy
    J Acquir Immune Defic Syndr 64:342-4. 2013
    ..These results suggest that DCs impairment found in HIV-infected patients may be related to a failure by bone marrow CD34 HPCs to produce an adequate number of DCs...
  6. ncbi request reprint Innate gamma/delta T-cells during HIV infection: Terra relatively Incognita in novel vaccination strategies?
    Chiara Agrati
    Laboratory of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy
    AIDS Rev 13:3-12. 2011
    ..In particular, strategies enhancing gamma/delta T-cell functions may open the possibility to formulate new immunotherapeutic regimens, which could impact the improvement of immune control of HIV disease...
  7. doi request reprint CD3zeta down-modulation may explain Vgamma9Vdelta2 T lymphocyte anergy in HIV-infected patients
    Alessandra Sacchi
    Laboratory of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    J Infect Dis 199:432-6. 2009
    ..Our findings may contribute to clarification of the molecular mechanisms of Vgamma9Vdelta2 T cell anergy found in HIV-positive patients...
  8. pmc Interferon-α improves phosphoantigen-induced Vγ9Vδ2 T-cells interferon-γ production during chronic HCV infection
    Eleonora Cimini
    Cellular Immunology Laboratory, National Institute for Infectious Diseases Lazzaro Spallanzani I R C C S, Rome, Italy
    PLoS ONE 7:e37014. 2012
    ..A study aimed to evaluate the antiviral impact of PhAg/IFN-α combination may provide new insight in designing possible combined strategies to improve HCV infection treatment outcome...
  9. doi request reprint GB-virus type C effect on HIV infection, interferon system, and dendritric cells
    Alessandra Sacchi
    National Institute for Infectious Diseases L Spallanzani, Rome, Italy
    Arch Med Res 39:362-3. 2008
  10. doi request reprint Cutting edge: TGF-beta1 and IL-15 Induce FOXP3+ gammadelta regulatory T cells in the presence of antigen stimulation
    Rita Casetti
    Laboratory of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani Instituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    J Immunol 183:3574-7. 2009
    ..Phenotypic and functional analyses of Vdelta2 Tregs will very likely improve our understanding about the role of gammadelta T cells in the pathogenesis of autoimmune, infectious, and neoplastic diseases...
  11. doi request reprint An abnormal phenotype of lung Vγ9Vδ2 T cells impairs their responsiveness in tuberculosis patients
    Sary El Daker
    Laboratory of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    Cell Immunol 282:106-12. 2013
    ..These observations indicate that γδ T cell functions are specifically impaired in situ by active TB, suggesting that the alveolar ambient during tuberculosis may affect resident γδ T cells in comparison to circulating cells. ..
  12. pmc Characterization of transglutaminase type II role in dendritic cell differentiation and function
    Ivana Matic
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    J Leukoc Biol 88:181-8. 2010
    ..Taken together, these data suggest that TG2 plays an important role in regulating the response of DCs to LPS and could be a candidate target for treating endotoxin-induced sepsis...
  13. ncbi request reprint Central memory Vgamma9Vdelta2 T lymphocytes primed and expanded by bacillus Calmette-Guérin-infected dendritic cells kill mycobacterial-infected monocytes
    Angelo Martino
    Unit of Cellular Immunology Fabrizio Poccia, National Institute for Infectious Diseases Lazzaro Spallanzani, Instituto di Ricovero e Cura a Carattere Scientifico, Via Portuense 292, Rome, Italy
    J Immunol 179:3057-64. 2007
    ..This study provides further evidences about the complex relationship between important players of innate immunity and suggests an immunoregulatory role of Vgamma9Vdelta2 T cells in the control of mycobacterial infection...
  14. ncbi request reprint Mycobacteria and dendritic cell differentiation: escape or control of immunity
    Angelo Martino
    Unit of Cellular Immunology, Padiglione Del Vecchio, National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Via Portuense 292, 00149 Rome, Italy
    Immunol Lett 102:115-7. 2006
    ..However, it could represents a new mechanism of immune escape by persistent pathogens or a control mechanism of immune system to preserve the life of the organ against persistent infections...
  15. ncbi request reprint Complementary function of gamma delta T-lymphocytes and dendritic cells in the response to isopentenyl-pyrophosphate and lipopolysaccharide antigens
    Angelo Martino
    Unit of Cellular Immunology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy
    J Clin Immunol 25:230-7. 2005
    ..Altogether, dendritic cells and gamma delta T-cells exert a complementary function promoting an optimal immune response to non peptidic microbial antigens...
  16. ncbi request reprint Dendritic cells derived from BCG-infected precursors induce Th2-like immune response
    Angelo Martino
    National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy
    J Leukoc Biol 76:827-34. 2004
    ..The induction of IL-4 production by DCs generated by BCG-infected monocytes could explain the failure of the BCG vaccine to prevent pulmonary tuberculosis...
  17. ncbi request reprint Inhibition of T cell proliferation by cholera toxin involves the modulation of costimulatory molecules CTLA-4 and CD28
    Silvia Vendetti
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, Rome, Italy
    Immunol Lett 115:59-69. 2008
    ..These findings show that the inhibition of T cell proliferation by CT affects early stages of the T cell activation and involves the modulation of costimulatory molecules CTLA-4 and CD28 on resting T cells...
  18. ncbi request reprint Non-pathogenic Mycobacterium smegmatis induces the differentiation of human monocytes directly into fully mature dendritic cells
    Angelo Martino
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    J Clin Immunol 25:365-75. 2005
    ..This could explain one of the mechanisms by which environmental mycobacteria can influence the immune response to pathogenic species...
  19. ncbi request reprint Cyclic adenosine 5'-monophosphate and calcium induce CD152 (CTLA-4) up-regulation in resting CD4+ T lymphocytes
    Silvia Vendetti
    Laboratory of Bacteriology and Medical Micology, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 169:6231-5. 2002
    ..These findings demonstrate that at least two novel signal pathways regulate CTLA-4 gene expression and CD152 molecule up-regulation in human CD4(+) T lymphocytes, in the absence of full T cell activation...