A Poggi

Summary

Affiliation: National Cancer Research Institute
Country: Italy

Publications

  1. ncbi NK cell activation by dendritic cells is dependent on LFA-1-mediated induction of calcium-calmodulin kinase II: inhibition by HIV-1 Tat C-terminal domain
    Alessandro Poggi
    Laboratory of Immunology, National Institute for Cancer Research, Genoa, Italy
    J Immunol 168:95-101. 2002
  2. doi Aminobisphosphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor Vδ 2 T lymphocytes in non-Hodgkin lymphomas
    Alessandra Musso
    Haematologica 99:131-9. 2014
  3. pmc Selective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human Natural Killer cells
    Alessandro Poggi
    Molecular Oncology and Angiogenesis Unit, IRCCS AOU San Martino IST National Institute for Cancer Research, Genoa, Italy
    PLoS ONE 8:e62932. 2013
  4. ncbi Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: role of NKp30 and NKG2D receptors
    Alessandro Poggi
    Laboratory of Experimental Oncology D, National Cancer Research Institute, Genoa, Italy
    J Immunol 175:6352-60. 2005
  5. doi Role of bone marrow stromal cells in the generation of human CD8+ regulatory T cells
    Alessandro Poggi
    Laboratory of Immunology, National Institute for Cancer Research, Genoa, Italy
    Hum Immunol 69:755-9. 2008
  6. doi Lack of the leukocyte-associated Ig-like receptor-1 expression in high-risk chronic lymphocytic leukaemia results in the absence of a negative signal regulating kinase activation and cell division
    A Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, Genoa, Italy
    Leukemia 22:980-8. 2008
  7. ncbi Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors
    Alessandro Poggi
    Laboratory of Immunology, National Institute for Cancer Research, University of Genoa, Genoa, Italy
    J Immunol 174:2653-60. 2005
  8. ncbi NKG2D and natural cytotoxicity receptors are involved in natural killer cell interaction with self-antigen presenting cells and stromal cells
    Alessandro Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, c o CBA Torre A1, Largo R Benzi 10, 16132 Genoa, Italy
    Ann N Y Acad Sci 1109:47-57. 2007
  9. pmc HIV-1 Tat triggers TGF-beta production and NK cell apoptosis that is prevented by pertussis toxin B
    Alessandro Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, Genoa, Italy
    Clin Dev Immunol 13:369-72. 2006
  10. ncbi Patients with paroxysmal nocturnal hemoglobinuria have a high frequency of peripheral-blood T cells expressing activating isoforms of inhibiting superfamily receptors
    Alessandro Poggi
    Laboratory of Experimental Oncology, Department of Translational Oncology, National Institute for Cancer Research, Genoa, Italy
    Blood 106:2399-408. 2005

Collaborators

Detail Information

Publications59

  1. ncbi NK cell activation by dendritic cells is dependent on LFA-1-mediated induction of calcium-calmodulin kinase II: inhibition by HIV-1 Tat C-terminal domain
    Alessandro Poggi
    Laboratory of Immunology, National Institute for Cancer Research, Genoa, Italy
    J Immunol 168:95-101. 2002
    ..These data provide evidence that exogenous Tat inhibits NK cell activation occurring upon contact with DC: this mechanism might contribute to the impairment of natural immunity in HIV-1 infection...
  2. doi Aminobisphosphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor Vδ 2 T lymphocytes in non-Hodgkin lymphomas
    Alessandra Musso
    Haematologica 99:131-9. 2014
    ....
  3. pmc Selective role of mevalonate pathway in regulating perforin but not FasL and TNFalpha release in human Natural Killer cells
    Alessandro Poggi
    Molecular Oncology and Angiogenesis Unit, IRCCS AOU San Martino IST National Institute for Cancer Research, Genoa, Italy
    PLoS ONE 8:e62932. 2013
    ..Altogether these findings suggest that interference with mevalonate synthesis impairs activation and assembly of cytoskeleton, degranulation and cytotoxic effect of perforins and granzyme but not FasL- and TNFα-mediated cytotoxicity...
  4. ncbi Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: role of NKp30 and NKG2D receptors
    Alessandro Poggi
    Laboratory of Experimental Oncology D, National Cancer Research Institute, Genoa, Italy
    J Immunol 175:6352-60. 2005
    ..It appears that HLA-I molecules do not protect BMSC from NK cell-mediated injury. Thus, NK cells, activated upon binding with BMSC, may regulate BMSC survival...
  5. doi Role of bone marrow stromal cells in the generation of human CD8+ regulatory T cells
    Alessandro Poggi
    Laboratory of Immunology, National Institute for Cancer Research, Genoa, Italy
    Hum Immunol 69:755-9. 2008
    ....
  6. doi Lack of the leukocyte-associated Ig-like receptor-1 expression in high-risk chronic lymphocytic leukaemia results in the absence of a negative signal regulating kinase activation and cell division
    A Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, Genoa, Italy
    Leukemia 22:980-8. 2008
    ..These results suggest that CLL lacking LAIR-1 may miss one of the molecular mechanisms controlling B-cell activation and proliferation...
  7. ncbi Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors
    Alessandro Poggi
    Laboratory of Immunology, National Institute for Cancer Research, University of Genoa, Genoa, Italy
    J Immunol 174:2653-60. 2005
    ..These findings indicate that NCR are not only triggering molecules essential for antitumor activity, but also surface receptors involved in NK cell suicide...
  8. ncbi NKG2D and natural cytotoxicity receptors are involved in natural killer cell interaction with self-antigen presenting cells and stromal cells
    Alessandro Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, c o CBA Torre A1, Largo R Benzi 10, 16132 Genoa, Italy
    Ann N Y Acad Sci 1109:47-57. 2007
    ..Altogether, these findings support the notion that NK cells can recognize self-cells possibly affecting both APC function and interaction between lymphocytes and microenvironment leading to autoreactivity...
  9. pmc HIV-1 Tat triggers TGF-beta production and NK cell apoptosis that is prevented by pertussis toxin B
    Alessandro Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, Genoa, Italy
    Clin Dev Immunol 13:369-72. 2006
    ..These data suggest that Tat-induced TGF-beta production and the consequent NK cell failure, possibly occurring during early HIV-1 infection, may be regulated by PTX-B and PT9K/129G...
  10. ncbi Patients with paroxysmal nocturnal hemoglobinuria have a high frequency of peripheral-blood T cells expressing activating isoforms of inhibiting superfamily receptors
    Alessandro Poggi
    Laboratory of Experimental Oncology, Department of Translational Oncology, National Institute for Cancer Research, Genoa, Italy
    Blood 106:2399-408. 2005
    ..Thus, T cells with NK-like features, expressing the activating isoforms of IRS, may include effector cells involved in the pathogenesis of PNH...
  11. ncbi Regulation of gammadelta T cell survival by soluble HLA-I: involvement of CD8 and activating killer Ig-like receptors
    Alessandro Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, Genoa, Italy
    Eur J Immunol 35:2670-8. 2005
    ..These findings suggest that sHLA-I can regulate gammadelta T cell survival and that activating KIR may amplify antigen-specific Vdelta2 T cell responses...
  12. ncbi Cyclosporin A regulates human NK cell apoptosis induced by soluble HLA-I or by target cells
    Alessandro Poggi
    Laboratory of Experimental Oncology D, Istituto Nazionale per la Ricerca sul Cancro, Largo R Benzi 10, 16132 Genoa, Italy
    Autoimmun Rev 4:532-6. 2005
    ..This would indicate that CsA can maintain NK cell-dependent innate immunity by prolonging NK cell survival in an hostile environment in the presence of sHLA-I or target cells...
  13. doi Effective in vivo induction of NKG2D ligands in acute myeloid leukaemias by all-trans-retinoic acid or sodium valproate
    A Poggi
    Laboratory of Immunology, Department of Translational Oncology, National Institute for Cancer Research, Genoa, Italy
    Leukemia 23:641-8. 2009
    ..These findings indicate that ATRA and VPA may contribute to the activation of cytolytic effector lymphocytes in vivo, possibly enhancing their anti-leukaemic effect...
  14. ncbi Gammadelta T lymphocytes producing IFNgamma and IL-17 in response to Candida albicans or mycobacterial antigens: possible implications for acute and chronic inflammation
    A Poggi
    Laboratory of Molecular Oncology and Angiogenesis, National Institute for Cancer Research, 16132 Genoa, Italy
    Curr Med Chem 16:4743-9. 2009
    ....
  15. doi Engagement of CD31 delivers an activating signal that contributes to the survival of chronic lymphocytic leukaemia cells
    Alessandro Poggi
    Laboratory of Molecular Oncology and Angiogenesis, National Institute for Cancer Research, University of Genoa, Italy
    Br J Haematol 151:252-64. 2010
    ..These data suggest that the CD31 adhesion system may play a role also in vivo in maintaining CLL survival...
  16. doi Differential survival of γδT cells, αβT cells and NK cells upon engagement of NKG2D by NKG2DL-expressing leukemic cells
    Alessandro Poggi
    Unit of Molecular Oncology and Angiogenesis, National Institute for Cancer Research, I 16132 Genoa
    Int J Cancer 129:387-96. 2011
    ..These biochemical data may explain, at least in part, why γδT and CD8(+) αβT cells are cytolytic effector cells more resistant to target-induced apoptosis than NK cells...
  17. ncbi Modulating mesenchymal stromal cell function with cholesterol synthesis inhibitors
    A Poggi
    Unit of Molecular Oncology and Angiogenesis, IRCCS AOU San Martino IST, National Institute for Cancer Research, Genoa, Italy
    Curr Med Chem 18:5196-205. 2011
    ..Herein, we analyze the effects that statins can exert on cancer cells, stromal cells and human natural killer cells, to discuss whether they can be proposed as anti-cancer drugs...
  18. pmc Relevance of the mevalonate biosynthetic pathway in the regulation of bone marrow mesenchymal stromal cell-mediated effects on T-cell proliferation and B-cell survival
    Alessandra Musso
    Molecular Oncology and Angiogenesis, Department of Translational Oncology, National Institute for Cancer Research Genoa, Genoa, Italy
    Haematologica 96:16-23. 2011
    ..Here we defined the effects of cholesterol synthesis inhibitors on the interaction between these mesenchymal stromal cells and T or B lymphocytes...
  19. ncbi Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias
    A Poggi
    Laboratory of Immunology, National Institute for Cancer Research, Genoa, Italy
    Eur J Immunol 30:2751-8. 2000
    ....
  20. ncbi Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction
    Grazia Maria Spaggiari
    Laboratory of Immunology, National Institute for Cancer Research IST, Genoa, Italy
    Blood 100:4098-107. 2002
    ....
  21. ncbi NK cell-mediated lysis of autologous antigen-presenting cells is triggered by the engagement of the phosphatidylinositol 3-kinase upon ligation of the natural cytotoxicity receptors NKp30 and NKp46
    G M Spaggiari
    Laboratory of Immunology, National Cancer Research Institute, Genova, Italy
    Eur J Immunol 31:1656-65. 2001
    ..Altogether, these findings strongly suggest that NCR are responsible for the killing of autologous APC through the activation of PI-3 K...
  22. ncbi The LFA-1/ICAM cell adhesion pathway is involved in tumor-cell lysis mediated by bispecific monoclonal-antibody-targeted T lymphocytes
    S Ferrini
    Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Int J Cancer 56:846-52. 1994
    ..These findings indicate that in T cells targeted by anti-CD3/anti-TAA biMAb LFA-1 may act as a co-receptor molecule which enhances signal transduction through the CD3/TCR complex...
  23. ncbi In vivo apoptosis of CD8(+) lymphocytes in acute myeloid leukemia patients: involvement of soluble HLA-I and Fas ligand
    P Contini
    Laboratory of Immunology, University of Genoa, Genoa, Italy
    Leukemia 21:253-60. 2007
    ..These data strongly suggest that in AML, increased levels of sHLA-I molecules may contribute to the elimination of potentially anti-tumor effector cells through a FasL/Fas interaction...
  24. ncbi CD8(+) T lymphocytes induce polarized exocytosis of secretory lysosomes by dendritic cells with release of interleukin-1beta and cathepsin D
    S Gardella
    Unit of Protein Biology, Laboratory of Immunology, and Biotechnology Section of Roma, National Cancer Research Institute, 16132 Genoa, Italy
    Blood 98:2152-9. 2001
    ..These events result in polarized exocytosis of secretory lysosomes, mediated by microtubules, with release of IL-1beta and cathepsin D toward the interacting CD8(+) T cell...
  25. ncbi Vdelta1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells and up-regulated by trans-retinoic acid
    Alessandro Poggi
    Laboratory of Immunology, National Cancer Research Institute, Genoa, Italy
    Cancer Res 64:9172-9. 2004
    ..These data suggest that Vdelta1 T lymphocytes may play a role in limiting the progression of B-CLL...
  26. ncbi Apoptosis of antigen-specific T lymphocytes upon the engagement of CD8 by soluble HLA class I molecules is Fas ligand/Fas mediated: evidence for the involvement of p56lck, calcium calmodulin kinase II, and Calcium-independent protein kinase C signaling pa
    Paola Contini
    Department of Internal Medicine and Center of Excellence for Biomedical Research, University of Genoa, Italy
    J Immunol 175:7244-54. 2005
    ..These findings clarify the intracellular signaling pathways triggering FasL up-regulation and apoptosis in CTL upon sHLA-I/CD8 ligation and suggest that sHLA-I molecules can be proposed as therapeutic tools to modulate immune responses...
  27. ncbi Soluble HLA class I molecules induce natural killer cell apoptosis through the engagement of CD8: evidence for a negative regulation exerted by members of the inhibitory receptor superfamily
    Grazia Maria Spaggiari
    Laboratory of Immunology, National Cancer Research Institute, Genoa, Italy
    Blood 99:1706-14. 2002
    ..These findings suggest that interaction between sHLA-I and CD8 evokes an apoptotic signal that is down-regulated by inhibitory receptor superfamily that function as survival receptors in NK cells...
  28. ncbi Migratory pathways of gammadelta T cells and response to CXCR3 and CXCR4 ligands: adhesion molecules involved and implications for multiple sclerosis pathogenesis
    A Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, Genoa, Italy
    Ann N Y Acad Sci 1107:68-78. 2007
    ..We suggest that both subsets of gammadelta T lymphocytes may migrate to the site of lesion in MS using two different signaling pathways to extravasate and responding to different chemokines...
  29. ncbi Mechanisms of tumor escape: role of tumor microenvironment in inducing apoptosis of cytolytic effector cells
    Alessandro Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, c o CBA Torre A1, Largo R Benzi 10, 16132 Genoa, Italy
    Arch Immunol Ther Exp (Warsz) 54:323-33. 2006
    ....
  30. ncbi Human natural killer lymphocytes through the engagement of natural cytotoxicity receptors and NKG2D can trigger self-aggression
    Alessandro Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, c o CBA Torre A1, Largo R Benzi 10, 16132 Genoa, Italy
    Autoimmun Rev 6:295-9. 2007
    ..On one hand this activation leads to the amplification of the NK arm of innate immune response; on the other hand, the lack of HLA-I-mediated control of such activation may lead to self-reactions elicited by NK cells...
  31. ncbi IFN-gamma production in human NK cells through the engagement of CD8 by soluble or surface HLA class I molecules
    Grazia Maria Spaggiari
    Laboratory of Immunology, National Institute for Cancer Research IST, Genoa, Italy
    Eur J Immunol 33:3049-59. 2003
    ..Altogether, these findings indicate that CD8 engagement by sHLA-I activates a cyclosporin A-dependent pathway leading to production and secretion of IFN-gamma which may play a role in the regulation of innate immune responses in humans...
  32. ncbi Transendothelial migratory pathways of V delta 1+TCR gamma delta+ and V delta 2+TCR gamma delta+ T lymphocytes from healthy donors and multiple sclerosis patients: involvement of phosphatidylinositol 3 kinase and calcium calmodulin-dependent kinase II
    Alessandro Poggi
    Laboratory of Immunology, National Institute for Cancer Research, Genoa, Italy
    J Immunol 168:6071-7. 2002
    ..These findings suggest that subsets of gammadelta T lymphocytes may migrate to the site of lesion in multiple sclerosis using two different signaling pathways to extravasate...
  33. ncbi The RGD-containing domain of exogenous HIV-1 Tat inhibits the engulfment of apoptotic bodies by dendritic cells
    M R Zocchi
    Laboratory of Clinical Pathology, National Institute for Cancer Research, Genoa, Italy
    AIDS 11:1227-35. 1997
    ..In order to investigate whether exogenous Tat can affect antigen presentation, the effects of synthetic Tat on the function of dendritic cells displaying antigen presenting cell phenotype were studied...
  34. ncbi The selective engulfment of apoptotic bodies by dendritic cells is mediated by the alpha(v)beta3 integrin and requires intracellular and extracellular calcium
    A Rubartelli
    Laboratory of Clinical Pathology, National Institute for Cancer Research, Genova, Italy
    Eur J Immunol 27:1893-900. 1997
    ..The different requirements of Ca2+ in macrophages and dendritic cells is possibly due to the differential usage of phagocytic receptors (CD36 vs. alpha(v)beta3) and might reflect different fates of apoptotic bodies in the two cell types...
  35. ncbi Expansion of Vdelta1 T lymphocytes producing IL-4 in low-grade non-Hodgkin lymphomas expressing UL-16-binding proteins
    Silvia Catellani
    Laboratory of Hematology, University of Genoa, Genoa, Italy
    Blood 109:2078-85. 2007
    ....
  36. ncbi Beta(3)-mediated engulfment of apoptotic tumor cells by dendritic cells is dependent on CAMKII: inhibition by HIV-1 Tat
    Alessandro Poggi
    Laboratory of Immunology, Unit of Protein Biology, National Cancer Research Institute, Genoa, Italy
    J Leukoc Biol 71:531-7. 2002
    ..Finally, pertussis toxin can prevent HIV-1 Tat-mediated inhibition, suggesting the involvement of a guanosine triphosphate-binding (G) protein in DC-mediated phagocytosis...
  37. doi Sensitivity of different resistant tumour cell lines to the two novel compounds (2Z,4E)-2-methylsulfanyl-5-(1-naphthyl)-4-nitro-2,4-pentadienoate and (1E,3E)-1,4-bis(2-naphthyl)-2,3-dinitro-1,3-butadiene
    Maurizio Viale
    Istituto Nazionale per la Ricerca sul Cancro, S C Terapia Immunologica, L go R Benzi 10, 16132 Genova, Italy
    Eur J Pharmacol 588:47-51. 2008
    ....
  38. ncbi Migration of V delta 1 and V delta 2 T cells in response to CXCR3 and CXCR4 ligands in healthy donors and HIV-1-infected patients: competition by HIV-1 Tat
    Alessandro Poggi
    Laboratory of Immunology, National Institute fo Cancer Research, Largo R Benzi 10, I 16132, Genoa, Italy
    Blood 103:2205-13. 2004
    ....
  39. ncbi MF-59 adjuvant influence on the functions of gammadelta T cells in HIV-1+ adults immunized with influenza seasonal vaccine
    D Fenoglio
    Clinic Immunology Unit, CEBR, University of Genoa, Italy
    J Prev Med Hyg 52:137-41. 2011
    ....
  40. ncbi Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction
    Claudia Prevosto
    Laboratory of Experimental Oncology D, National Cancer Research Institute, 16132 Genoa, Italy
    Haematologica 92:881-8. 2007
    ..We analyzed whether regulatory T cells can be generated in co-cultures of peripheral blood mononuclear cells (PBMC) and MSC...
  41. pmc Antigen presenting cells and stromal cells trigger human natural killer lymphocytes to autoreactivity: evidence for the involvement of natural cytotoxicity receptors (NCR) and NKG2D
    Alessandro Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, 16132, Genoa, Italy
    Clin Dev Immunol 13:325-36. 2006
    ..Finally, NK cells can revert the veto effect of stromal cells on mixed lymphocyte reaction further supporting the idea that NK cells may alter the interaction between T lymphocytes and microenvironment leading to autoreactivity...
  42. ncbi NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1
    Claudia Semino
    Laboratory of Cell Biology, Department of Translational Oncology, National Institute for Cancer Research, Largo Rosanna Benzi, 10, 16132 Genova, Italy
    Blood 106:609-16. 2005
    ....
  43. pmc Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE
    Santina Bruzzone
    Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Genoa, Italy
    PLoS ONE 4:e7897. 2009
    ..In conclusion, Nampt inhibitors (and possibly Sirt6 inhibitors) could be used to modulate T cell-mediated immune responses and thereby be beneficial in immune-mediated disorders...
  44. doi Vdelta1 T lymphocytes producing IFN-gamma and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans
    Daniela Fenoglio
    Centre of Excellence for Biological Sciences, University of Genoa, Genoa, Italy
    Blood 113:6611-8. 2009
    ....
  45. ncbi p40, a novel surface molecule involved in the regulation of the non-major histocompatibility complex-restricted cytolytic activity in humans
    A Poggi
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Eur J Immunol 25:369-76. 1995
    ..In conclusion, p40 molecules represent a new type of inhibitory surface molecule that appears to play a general regulatory role in the NK-mediated cytolysis...
  46. ncbi Complementation of the oxidatively damaged DNA repair defect in Cockayne syndrome A and B cells by Escherichia coli formamidopyrimidine DNA glycosylase
    Monica Ropolo
    Experimental Oncology B Laboratory, Department of Translational Oncology, Istituto Nazionale Ricerca Cancro, Largo Rosanna Benzi n 10, 16132 Genova, Italy
    Free Radic Biol Med 42:1807-17. 2007
    ..The data indicate that 8-oxoGua is not a major toxic and clastogenic lesion in CS cells...
  47. ncbi A novel Bim-BH3-derived Bcl-XL inhibitor: biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity
    Raffaella Ponassi
    Department of Oncology, University of Genoa, Genoa, Italy
    Cell Cycle 7:3211-24. 2008
    ..Altogether, these observations support the therapeutic potentials of this novel BH3 mimetic...
  48. pmc Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes
    Cristina Andrei
    Cell Transport Unit, Department of Oncogenesis, National Cancer Research Institute, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 101:9745-50. 2004
    ..This activation is ultimately responsible for lysosome exocytosis and IL-1 beta secretion...
  49. ncbi Accelerated repair and reduced mutagenicity of oxidative DNA damage in human bladder cells expressing the E. coli FPG protein
    Monica Ropolo
    Department of Translational Oncology, Experimental Oncology B Laboratory, Istituto Nazionale Ricerca Cancro, Largo Rosanna Benzi n 10, 16132 Genova, Italy
    Int J Cancer 118:1628-34. 2006
    ..FPG may stably protect human cells from some harmful effects of oxidative DNA damage...
  50. ncbi Role of gammadelta T lymphocytes in tumor defense
    Maria Raffaella Zocchi
    Laboratory of Tumor Immunology and Department of Internal Medicine, H San Raffaele Scientific Institute, Via Olgettina 60, I 20132 Milano, Italy
    Front Biosci 9:2588-604. 2004
    ..Here, we discuss the potential role played by resident Vdelta1+ and circulating Vdelta2+ T lymphocytes in the defense against solid tumors and hematological malignancies...
  51. ncbi Novel cell death pathways induced by N-(4-hydroxyphenyl)retinamide: therapeutic implications
    Roberta Vené
    IRCCS Multimedica, Polo Scientifico e Tecnologico, Settore Ricerca Oncologica, Via Fantoli 15 16, Milan, Italy
    Mol Cancer Ther 6:286-98. 2007
    ..The novel finding of a lysosome-mediated cell death pathway activated by 4HPR could have implications at clinical level for the development of combination chemoprevention and therapy of cancer...
  52. ncbi Atherosclerotic abdominal aortic aneurysm and the interaction between autologous human plaque-derived vascular smooth muscle cells, type 1 NKT, and helper T cells
    Woon Ling Chan
    Department of Biochemical Pharmacology, William Harvey Research Institute, Queen Mary, University of London, London, UK
    Circ Res 96:675-83. 2005
    ....
  53. ncbi Soluble HLA-A,-B,-C and -G molecules induce apoptosis in T and NK CD8+ cells and inhibit cytotoxic T cell activity through CD8 ligation
    Paola Contini
    Department of Internal Medicine DIMI, University of Genova, Genova, Italy
    Eur J Immunol 33:125-34. 2003
    ..In contrast, non-classical HLA class I molecules may exert immunomodulatory effects in particular conditions characterized by elevated sHLA-G levels such as pregnancy and some neoplastic diseases...
  54. ncbi Human invariant NKT cells display alloreactivity instructed by invariant TCR-CD1d interaction and killer Ig receptors
    Scott Patterson
    Department of Hematology, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom
    J Immunol 181:3268-76. 2008
    ..Thus, iNKT cells can display alloreactivity, for which they use mechanisms characteristic of both NK and conventional T cells...
  55. ncbi Pertussis toxin (PTX) B subunit and the nontoxic PTX mutant PT9K/129G inhibit Tat-induced TGF-beta production by NK cells and TGF-beta-mediated NK cell apoptosis
    M Raffaella Zocchi
    Laboratory of Tumor Immunology and AIDS Immunopathogenesis Unit, Department of Immunology and Infectious Diseases, Scientific Institute San Raffaele, Milan, Italy
    J Immunol 174:6054-61. 2005
    ..Together, these data suggest that Tat-induced TGF-beta production and the consequent NK cell failure, possibly occurring during early HIV-1 infection, may be regulated by PTX-B and PT9K/129G...
  56. ncbi Expression of the Drosophila melanogaster S3 ribosomal/repair protein in T24 human bladder cells
    Monica Ropolo
    Mutagenesis Laboratory, Istituto Nazionale Ricerca Cancro, Largo Rosanna Benzi n 10, 16132 Genova, Italy
    Anticancer Res 24:3811-8. 2004
    ....
  57. ncbi Adhesion molecules and kinases involved in gammadelta T cells migratory pathways: implications for viral and autoimmune diseases
    Alessandro Poggi
    Laboratory of Tumor Immunology, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Curr Med Chem 14:3166-70. 2007
    ..Finally, the possible role of gammadelta T lymphocytes in post-transplantation immune reconstitution is discussed...
  58. ncbi Transendothelial migration leads to protection from starvation-induced apoptosis in CD34+CD14+ circulating precursors: evidence for PECAM-1 involvement through Akt/PKB activation
    Elisabetta Ferrero
    Laboratory of Tumor Immunology, the Human Virology Unit, DIBIT, Italy
    Blood 101:186-93. 2003
    ....
  59. doi Paroxysmal nocturnal hemoglobinuria: significant association with specific HLA-A, -B, -C, and -DR alleles in an Italian population
    Maria Luisa Lombardi
    Dipartimento di Oncologia Sperimentale, Istituto Nazionale Tumori di Napoli, Napoli, Italy
    Hum Immunol 69:202-6. 2008
    ..0005) and a 15-fold increase of the Mediterranean haplotype A*33, B*1402, Cw*0802, DRB1*0102, DQB1*0501 (p < 0.005) was also revealed. This association may provide new insights into the autoimmune pathogenesis of PNH...