Daniela Pende

Summary

Affiliation: National Cancer Research Institute
Country: Italy

Publications

  1. ncbi Human natural killer cells: their origin, receptors and function
    Lorenzo Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genova, Italy
    Eur J Immunol 32:1205-11. 2002
  2. ncbi PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Mol Immunol 42:463-9. 2005
  3. pmc Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems
    Jane C Stinchcombe
    Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
    BMC Biol 9:45. 2011
  4. ncbi Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Blood 107:2030-6. 2006
  5. doi Anti-leukemia activity of alloreactive NK cells in KIR ligand-mismatched haploidentical HSCT for pediatric patients: evaluation of the functional role of activating KIR and redefinition of inhibitory KIR specificity
    Daniela Pende
    Immunologia, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Blood 113:3119-29. 2009
  6. ncbi Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112)
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Blood 105:2066-73. 2005
  7. pmc Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule
    Cristina Bottino
    Dipartimento di Medicina Sperimentale, Sezione di Istologia, Via G B Marsano 10, 16132 Genova, Italy
    J Exp Med 198:557-67. 2003
  8. ncbi Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction
    Roberta Castriconi
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genoa, Italy
    Cancer Res 64:9180-4. 2004
  9. pmc Susceptibility of human melanoma cells to autologous natural killer (NK) cell killing: HLA-related effector mechanisms and role of unlicensed NK cells
    Paolo Carrega
    Istituto Giannina Gaslini, Genoa, Italy
    PLoS ONE 4:e8132. 2009
  10. ncbi Isolation of a novel KIR2DL3-specific mAb: comparative analysis of the surface distribution and function of KIR2DL2, KIR2DL3 and KIR2DS2
    Massimo Vitale
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Int Immunol 16:1459-66. 2004

Collaborators

Detail Information

Publications38

  1. ncbi Human natural killer cells: their origin, receptors and function
    Lorenzo Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genova, Italy
    Eur J Immunol 32:1205-11. 2002
    ..As a consequence, NK cells lyse target cells that have lost (or express insufficient amounts of) MHC class I molecules, as frequently occurs in tumors and in cells infected by certain viruses...
  2. ncbi PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Mol Immunol 42:463-9. 2005
    ..Importantly, the specific interaction between DNAM-1 (in NK cells) and PVR or Nectin-2 (in target cells) enhanced the NK-mediated lysis of tumor cells that was downregulated by mAb-mediated masking of the receptor or its ligands...
  3. pmc Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems
    Jane C Stinchcombe
    Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
    BMC Biol 9:45. 2011
    ....
  4. ncbi Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Blood 107:2030-6. 2006
    ....
  5. doi Anti-leukemia activity of alloreactive NK cells in KIR ligand-mismatched haploidentical HSCT for pediatric patients: evaluation of the functional role of activating KIR and redefinition of inhibitory KIR specificity
    Daniela Pende
    Immunologia, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Blood 113:3119-29. 2009
    ..A role of the KIR2DS2 activating receptor in leukemia cell lysis could not be demonstrated. Altogether, these results may have important clinical implications for the selection of optimal donors for haplo-HSCT...
  6. ncbi Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112)
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Blood 105:2066-73. 2005
    ..In most leukemias, both CD48 and NTBA were down-regulated. The correlation found between marker expression and susceptibility to lysis may reveal useful information for NK-based immunotherapy...
  7. pmc Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule
    Cristina Bottino
    Dipartimento di Medicina Sperimentale, Sezione di Istologia, Via G B Marsano 10, 16132 Genova, Italy
    J Exp Med 198:557-67. 2003
    ..This lysis was inhibited or even virtually abrogated upon mAb-mediated masking of DNAM-1 (on NK cells) or PVR or Nectin-2 ligands (on cell transfectants)...
  8. ncbi Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction
    Roberta Castriconi
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genoa, Italy
    Cancer Res 64:9180-4. 2004
    ..Thus, assessment of the PVR surface levels may represent a novel useful criterion to predict the susceptibility/resistance of neuroblastomas to NK-mediated killing...
  9. pmc Susceptibility of human melanoma cells to autologous natural killer (NK) cell killing: HLA-related effector mechanisms and role of unlicensed NK cells
    Paolo Carrega
    Istituto Giannina Gaslini, Genoa, Italy
    PLoS ONE 4:e8132. 2009
    ....
  10. ncbi Isolation of a novel KIR2DL3-specific mAb: comparative analysis of the surface distribution and function of KIR2DL2, KIR2DL3 and KIR2DS2
    Massimo Vitale
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Int Immunol 16:1459-66. 2004
    ....
  11. ncbi Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
    Cancer Res 62:6178-86. 2002
    ..Our data suggest that the involvement of NKG2D in natural killer cell-mediated cytotoxicity strictly correlates with the expression and the surface density of MICA and ULBP on target cell tumors of different histotypes...
  12. ncbi Cellular and molecular basis of natural killer and natural killer-like activity
    Lorenzo Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Via L B Alberti no 2, 16132 Genova, Italy
    Immunol Lett 88:89-93. 2003
    ....
  13. ncbi Human natural killer cells: Molecular mechanisms controlling NK cell activation and tumor cell lysis
    Lorenzo Moretta
    Istituto Giannina Gaslini, Largo Gerolamo Gaslini 5, 16147 Genova Quarto, Italy
    Immunol Lett 100:7-13. 2005
    ..This clearly implies that activation of NK cells and of their potent effector mechanism are under the control of different checkpoints...
  14. ncbi Surface NK receptors and their ligands on tumor cells
    Lorenzo Moretta
    Istituto Giannina Gaslini, L go G Gaslini, Genova, Italy
    Semin Immunol 18:151-8. 2006
    ..Here we briefly illustrate the main NK receptors and their cellular ligands and we delineate the major receptor/ligands interactions leading to NK cell activation and tumor cell lysis...
  15. ncbi Analysis of natural killer-cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease
    Stefania Marcenaro
    Istituto Giannina Gaslini, Genoa, Italy the Sir William Dunn School of Pathology, Oxford, United Kingdom
    Blood 108:2316-23. 2006
    ..This could reflect survival versus elimination of B-EBV cells (ie, the source of NK-cell stimulation) in patients versus healthy control subjects, thus mimicking the pathophysiologic scenario of FHL...
  16. pmc Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection
    Domenico Mavilio
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:2339-50. 2006
    ....
  17. ncbi Effector and regulatory events during natural killer-dendritic cell interactions
    Lorenzo Moretta
    Direzione Scientifica, Istituto Giannina Gaslini, Largo G Gaslini, Genova Quarto, Italy
    Immunol Rev 214:219-28. 2006
    ..These interactions also determine the quality and strength of the subsequent adaptive responses. Remarkably, NK cells appear to play a key role in this complex network...
  18. ncbi Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses
    Shlomo Nedvetzki
    Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London, UK
    Blood 109:3776-85. 2007
    ....
  19. pmc Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value
    Loredana Ruggeri
    Division of Hematology and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Istituto di Ricovero e Cura a Carattere Scientifico, Foundation on Transplantation Biotechnologies, Perugia, Italy
    Blood 110:433-40. 2007
    ..Only transplantation from NK-alloreactive donors is associated with a survival advantage...
  20. ncbi NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor
    Massimo Vitale
    Istituto Scientifico per la Ricerca sul Cancro IST, Genova, Italy
    Blood 106:566-71. 2005
    ..Finally, the analysis of perforin-deficient NK cells allowed the dissection of the 2 NKp30-mediated NK-cell functions, since NKp30 could induce cytokine-dependent DC maturation in the absence of NK-mediated DC killing...
  21. ncbi Human NK cells and their receptors
    Lorenzo Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genova, Italy
    Microbes Infect 4:1539-44. 2002
    ..host disease. This may lead to a true revolution in bone marrow transplantation, based on the exploitation of appropriate HLA-Cl I mismatches that can put NK cells in action...
  22. ncbi Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia
    Regis T Costello
    Unité d Immunologie des Tumeurs Département d Hématologie, Institut Paoli Calmettes, Universite de la Mediterranee, Marseille, France
    Blood 99:3661-7. 2002
    ..In few cases, however, this failure appears to involve a mechanism of tumor escape based on down-regulation of ligands relevant for NCR-mediated target cell recognition...
  23. ncbi Learning how to discriminate between friends and enemies, a lesson from Natural Killer cells
    Cristina Bottino
    Istituto Giannina Gaslini, L go G Gaslini 5, Genova 16148, Italy
    Mol Immunol 41:569-75. 2004
    ..Finally, the ability of NK cells to interact with normal, non-transformed other cells such as dendritic cells (DC) appears to crucially contribute to the regulation of both innate and adaptive immune responses...
  24. ncbi HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells
    Ennio Carbone
    Dipartimento di Medicina Sperimentale e Clinica G Salvatore, Università di Catanzaro Magna Graecia, Catanzaro, Italy
    Blood 105:251-8. 2005
    ..Our data support the hypothesis that NK cell cytotoxicity could sculpture myeloma and represents an important immune effector mechanism in controlling its intramedullary stages...
  25. ncbi Different checkpoints in human NK-cell activation
    Lorenzo Moretta
    Istituto Giannina Gaslini, Largo Gerolamo Gaslini 5, 16147 Genova Quarto, Italy
    Trends Immunol 25:670-6. 2004
    ..Thus, it appears that the activation of NK cells and their potentially harmful effector functions are under the control of different checkpoints...
  26. pmc Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma
    Lizzia Raffaghello
    Laboratory of Oncology, G Gaslini Institute, Genova, Italy
    Neoplasia 6:558-68. 2004
    ..ULBP-3 was expressed in 5 of 9 cell lines, ULBP-2 in 2 of 9, whereas ULBP-1 was never detected. These studies delineate novel potential pathways of tumor escape and immunodeficiency in NB...
  27. ncbi A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin
    Christina Trambas
    Sir William Dunn School of Pathology, South Parks Rd, Oxford OX1 3RE, United Kingdom
    Blood 106:932-7. 2005
    ..The conformational changes and impaired cleavage of A91V perforin are likely to explain the reduced cytotoxicity in CTLs and NK cells from this patient and are likely to contribute to the pathogenesis of HLH...
  28. ncbi Haemophagocytic lymphohistiocytosis: proposal of a diagnostic algorithm based on perforin expression
    Maurizio Arico
    Onco Ematologia Pediatrica, Ospedale dei Bambini G Di Cristina, Palermo, Italy
    Br J Haematol 119:180-8. 2002
    ..Our flow chart could also lead to better selection of patients for specific gene analysis...
  29. pmc Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals
    Manuela Fogli
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 4:e1000101. 2008
    ....
  30. doi Mutations affecting mRNA splicing are the most common molecular defect in patients with familial hemophagocytic lymphohistiocytosis type 3
    Alessandra Santoro
    Divisione di Ematologia I, A O V Cervello, Palermo, Italy
    Haematologica 93:1086-90. 2008
    ..This finding has implications for designing strategies for analysis of the families with suspected familial hemophagocytic lymphohistiocytosis...
  31. doi Natural killer cells in lymph nodes of healthy calves express CD16 and show both cytotoxic and cytokine-producing properties
    Preben Boysen
    Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, P O Box 8146 Dep, N 0033 Oslo, Norway
    Dev Comp Immunol 32:773-83. 2008
    ..These findings suggest a cytotoxic role of lymph node residing NK cells, beyond the predominantly cytokine-producing role previously inferred from studies on human NK cells...
  32. ncbi NKG2D-mediated antitumor activity by tumor-infiltrating lymphocytes and antigen-specific T-cell clones isolated from melanoma patients
    Cristina Maccalli
    Unit of Immunotherapy of Human Tumors, Istituto Nazionale Tumori, Milan, Italy
    Clin Cancer Res 13:7459-68. 2007
    ..The role of NKG2D receptor in antitumor immunosurveillance has not been completely clarified. We addressed this issue by investigating the involvement of this receptor in tumor-specific immunologic response in melanoma patients...
  33. ncbi Inhibitory receptor signals suppress ligation-induced recruitment of NKG2D to GM1-rich membrane domains at the human NK cell immune synapse
    Johanna Endt
    Institute for Immunology, University Heidelberg, Im Neuenheimer Feld 305, Heidelberg, Germany
    J Immunol 178:5606-11. 2007
    ..The accumulation of activating NK cell receptors in GM1-rich microdomains may provide the necessary platform from which stimulatory signals can proceed...
  34. ncbi NKG2D engagement of colorectal cancer-specific T cells strengthens TCR-mediated antigen stimulation and elicits TCR independent anti-tumor activity
    Cristina Maccalli
    Unit of Immunotherapy of Human Tumors, Istituto Nazionale Tumori, Via Venezian 1, I 20133 Milan, Italy
    Eur J Immunol 33:2033-43. 2003
    ..Taken together these data indicate that the engagement of NKG2D, depending on the expression of its ligands by target cells, can influence the pattern of anti-tumor reactivity by T lymphocytes...
  35. ncbi CD8(+) T lymphocytes isolated from renal cancer patients recognize tumour cells through an HLA- and TCR/CD3-independent pathway
    Ilaria Lionello
    Cancer Immunotherapy and Gene Therapy Program, Scientific Institute H San Raffaele, Milan, Italy
    Cancer Immunol Immunother 56:1065-76. 2007
    ..The aim of this study was to characterize the immune response of patients affected by renal cell carcinoma (RCC)...
  36. ncbi Expression and function of NKG2D in CD4+ T cells specific for human cytomegalovirus
    Andrea Sáez-Borderías
    Molecular Immunopathology Unit, Universitat Pompeu Fabra DCEXS, Barcelona, Spain
    Eur J Immunol 36:3198-206. 2006
    ....
  37. ncbi Effect of human natural killer and gammadelta T cells on the growth of human autologous melanoma xenografts in SCID mice
    Francesco Lozupone
    Laboratories of Immunology and Virology, Istituto Superiore di Sanita, Rome, Italy
    Cancer Res 64:378-85. 2004
    ..Moreover, our study emphasizes the usefulness of human tumor/SCID mouse models for preclinical evaluation of immunotherapy protocols against human tumors...
  38. ncbi Natural killer and NK-Like T-cell activation in colorectal carcinoma patients treated with autologous tumor-derived heat shock protein 96
    Lorenzo Pilla
    Unit of Immunotherapy of Human Tumors, Istituto Nazionale Tumori, Milan, Italy
    Cancer Res 65:3942-9. 2005
    ..Altogether, these findings identify the activation of the NK compartment as an additional immunologic effect of autologous tumor-derived HSP96 administration in cancer patients...