Affiliation: National Institute for Food and Nutrition Research
- Modulation of kinase activity by polyphenolsMirella Nardini
National Institute for Food and Nutrition Research, 00178 Rome, Italy
Ann N Y Acad Sci 973:368-70. 2002
- Role of dietary polyphenols in platelet aggregation. A review of the supplementation studiesMirella Nardini
National Research Institute for Food and Nutrition, Via Ardeatina 546, 00178 Roma Italy
Platelets 18:224-43. 2007....
- Phenolic acids from beer are absorbed and extensively metabolized in humansMirella Nardini
Free Radical Research Group, National Institute for Food and Nutrition Research, 00178 Rome, Italy
J Nutr Biochem 17:14-22. 2006..The extent of conjugation is related to the chemical structure of phenolic acids: the monohydroxy derivatives showing the lowest conjugation degree and the dihydroxy derivatives showing the highest one...
- Determination of aminoethylcysteine ketimine decarboxylated dimer in human plasma and cultured cells by high-performance liquid chromatography with electrochemical detectionM Nardini
Free Radical Research Group, National Institute for Food and Nutrition Research, Via Ardeatina 546, 00178 Rome, Italy
J Chromatogr B Analyt Technol Biomed Life Sci 795:319-27. 2003..The method showed the required features of specificity and sensitivity to detect aminoethylcysteine ketimine decarboxylated dimer in human plasma and in cultured cells after in vitro supplementation...
- Absorption of phenolic acids in humans after coffee consumptionM Nardini
National Institute for Food and Nutrition Research, Via Ardeatina 546, 00178 Rome, Italy
J Agric Food Chem 50:5735-41. 2002..Due to the absence of free caffeic acid in coffee, plasma caffeic acid is likely to be derived from hydrolysis of chlorogenic acid in the gastrointestinal tract...
- Acrolein-induced cytotoxicity in cultured human bronchial epithelial cells. Modulation by alpha-tocopherol and ascorbic acidMirella Nardini
Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione, Via Ardeatina 546, 00178, Rome, Italy
Toxicology 170:173-85. 2002..The intracellular generation of oxidants following acrolein exposure seems to be an important event triggering the apoptotic response in this model system...
- Coffee drinking induces incorporation of phenolic acids into LDL and increases the resistance of LDL to ex vivo oxidation in humansFausta Natella
National Research Institute for Food and Nutrition, Rome, Italy
Am J Clin Nutr 86:604-9. 2007..Coffee contains phenolic compounds with antioxidant activity. These molecules are found in plasma after the consumption of coffee, and it has been shown that, in vitro, they are able to decrease the susceptibility of LDL to oxidation...
- Coffee drinking influences plasma antioxidant capacity in humansFausta Natella
Free Radical Research Group, National Research Institute for Food and Nutrition, Via Ardeatina 546, 00178 Roma, Italy
J Agric Food Chem 50:6211-6. 2002....
- Characterization of phenolics content and antioxidant activity of different beer typesAlessandro Piazzon
National Institute for Food and Nutrition Research, Via Ardeatina 546, 00178 Rome, Italy
J Agric Food Chem 58:10677-83. 2010..FRAP values strictly correlate with polyphenols and phenolic acids content. The contribution of single phenolic acids to the antioxidant activity measured with FRAP assay was also studied...
- White wine phenolics are absorbed and extensively metabolized in humansMirella Nardini
National Institute for Food and Nutrition Research INRAN, Via Ardeatina 546, 00178 Rome, Italy
J Agric Food Chem 57:2711-8. 2009..Unmodified tartaric acid esters of hydroxycinnamic acids from wine are present in human plasma at low levels, if any. Wine hydroxycinnamic acids, although present in wine as conjugated forms, are still bioavailable to humans...
- Effect of arachidonic, eicosapentaenoic and docosahexaenoic acids on the oxidative status of C6 glioma cellsFabiana Leonardi
Food Science, Nutrition and Health Department, Intituto Superiore di Sanità, Rome, Italy
Free Radic Res 39:865-74. 2005..No significant changes were observed in the ARA group with respect to untreated cells. These data show that EPA and DHA induce alterations in the oxidative status that could affect the glial function...
- Effect of coffee drinking on platelets: inhibition of aggregation and phenols incorporationF Natella
National Research Institute on Food and Nutrition, INRAN, Via Ardeatina 546, 00178 Roma, Italy
Br J Nutr 100:1276-82. 2008..The antiplatelet effect of coffee is independent from caffeine and could be a result of the interaction of coffee phenolic acids with the intracellular signalling network leading to platelet aggregation...
- Absorption of aminoethyl cysteine ketimine decarboxylated dimer in mice: effect on plasma antioxidant potentialAlessandro Piazzon
National Institute for Food and Nutrition Research, Via Ardeatina 546, 00178, Rome, Italy
J Agric Food Chem 60:4596-602. 2012..These results demonstrate for the first time the absorption of AECK-DD from diet and the physiological relevance of this compound through its antioxidant action in vivo...
- Modulation of ceramide-induced NF-kappaB binding activity and apoptotic response by caffeic acid in U937 cells: comparison with other antioxidantsM Nardini
Free Radical Research Group, National Institute for Food and Nutrition Research, Rome, Italy
Free Radic Biol Med 30:722-33. 2001..Our results suggest that dietary caffeic acid might modulate ceramide-induced signal transduction pathway and NF-kappaB activation through either antioxidant and nonantioxidant mechanisms...
- Effect of caffeic acid on tert-butyl hydroperoxide-induced oxidative stress in U937M Nardini
Free Radical Research Group, National Institute of Nutrition, Rome, Italy
Free Radic Biol Med 25:1098-105. 1998..Due to its presence in the diet, therefore, caffeic acid may play a role in the modulation of oxidative processes in vivo...
- In vitro inhibition of the activity of phosphorylase kinase, protein kinase C and protein kinase A by caffeic acid and a procyanidin-rich pine bark (Pinus marittima) extractM Nardini
Free Radical Research Group, National Institute of Nutrition, Via Ardeatina 546, 00178, Rome, Italy
Biochim Biophys Acta 1474:219-25. 2000..For PhK and PKA, the inhibition follows a non-competitive mechanism. CA also inhibits PKC activity in a partially purified cellular extract. The results suggest a possible involvement of CA and PBE in modulation of cellular functions...
- Docosahexaenoic acid supplementation induces dose and time dependent oxidative changes in C6 glioma cellsFabiana Leonardi
Department of Food Science, Nutrition and Health, Istituto Superiore di Sanita, V Ie Regina Elena, Roma, Italy
Free Radic Res 41:748-56. 2007..Therefore, the final effect of DHA on cellular redox status is dependent on dose and time supplementation...
- Effect of aminoethylcysteine ketimine decarboxylated dimer, a natural sulfur compound present in human plasma, on tert-butyl hydroperoxide-induced oxidative stress in human monocytic U937 cellsAlberto Macone
Department of Biochemical Sciences A Rossi Fanelli, University of Rome La Sapienza, Rome 00185, Italy
Free Radic Res 38:705-14. 2004..Due to its presence in both human plasma and urine, AECK-DD may play a role in the modulation of oxidative processes in vivo...
- Identification of aminoethylcysteine ketimine decarboxylated dimer, a natural antioxidant, in dietary vegetablesAlberto Macone
Dipartimento di Scienze Biochimiche A Rossi Fanelli and Centro di Biologia Molecolare del CNR, Universita degli Studi di Roma La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
J Agric Food Chem 50:2169-72. 2002..Results from GC analysis range in the order of 10(-4) micromol of dimer/g for all the tested vegetables. These results and the lack of a demonstrated biosynthetic pathway in humans might account for a dietary supply of this molecule...
- Inhibition of NFkappaB activation and IL-8 expression in human bronchial epithelial cells by acroleinGiuseppe Valacchi
Division of Pulmonary and Critical Care Medicine, UC Davis, Davis, CA 95616, USA
Antioxid Redox Signal 7:25-31. 2005..In summary, our results demonstrate that acrolein can suppress inflammatory processes in the airways by inhibiting epithelial IL-8 production through direct or indirect inhibitory effects on NFkappaB activation...
- Synthesis and characterization of a dehydrogenation product arising from the oxidation of aminoethylcysteine ketimine decarboxylated dimerAlberto Macone
Department of Biochemical Sciences A Rossi Fanelli and National Research Council Institute of Molecular Biology and Pathology, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
J Nat Prod 70:1046-8. 2007..This compound was identified and characterized through comparison with an authentic sample prepared via Pd-catalyzed dehydrogenation of 1. This molecule is an example of an alternative oxidation pathway involving 1...