Enrico Girardi

Summary

Affiliation: National Institute for Infectious Diseases
Country: Italy

Publications

  1. pmc Response to M. tuberculosis selected RD1 peptides in Ugandan HIV-infected patients with smear positive pulmonary tuberculosis: a pilot study
    Delia Goletti
    Translational Research Unit, Department of Experimental Research, Istituto Nazionale Malattie Infettive Lazzaro Spallanzani IRCCS Rome, Italy
    BMC Infect Dis 8:11. 2008
  2. ncbi request reprint Epidemiological aspects of transmitted HIV drug resistance
    Enrico Girardi
    Department of Epidemiology, National Institute of Infectious Diseases L Spallanzani, IRCCS, Rome, Italy
    Scand J Infect Dis Suppl 106:17-20. 2003
  3. pmc Isoniazid prophylaxis differently modulates T-cell responses to RD1-epitopes in contacts recently exposed to Mycobacterium tuberculosis: a pilot study
    Delia Goletti
    Translational Research Unit, Department of Experimental Research, Istituto Nazionale Malattie Infettive Lazzaro Spallanzani, IRCCS Rome, Italy
    Respir Res 8:5. 2007
  4. pmc Characterization of the patterns of drug-resistance mutations in newly diagnosed HIV-1 infected patients naïve to the antiretroviral drugs
    Claudia Alteri
    Department of Experimental Medicine and Biochemical Sciences, University of Tor Vergata Rome, Italy
    BMC Infect Dis 9:111. 2009
  5. ncbi request reprint Trends in HIV prevalence among pregnant women in Italy, 1994 to 2002
    Enrico Girardi
    Dipartimento di Epidemiologia, Istituto Nazionale per le Malattie Infettive L Spallanzani IRCCS, Via Portuense 292, 00149 Rome, Italy
    J Acquir Immune Defic Syndr 41:361-4. 2006
  6. ncbi request reprint Incidence of Tuberculosis among HIV-infected patients receiving highly active antiretroviral therapy in Europe and North America
    Enrico Girardi
    Dipartimento di Epidemiologia, Istituto Nazionale per le Malattie Infettive L Spallanzani IRCCS, Via Portuense 292, 00149 Rome, Italy
    Clin Infect Dis 41:1772-82. 2005
  7. ncbi request reprint Late diagnosis of HIV infection: epidemiological features, consequences and strategies to encourage earlier testing
    Enrico Girardi
    UOC Epidemiologia Clinica, Istituto Nazionale per le Malattie Infettive L Spallanzani IRCCS, Rome, Italy
    J Acquir Immune Defic Syndr 46:S3-8. 2007
  8. ncbi request reprint Tuberculosis in HIV-infected persons in the context of wide availability of highly active antiretroviral therapy
    E Girardi
    Dipartimento di Epidemiologia, Istituto Nazionale per le Malattie Infettive L Spallanzani IRCCS, Rome, Italy
    Eur Respir J 24:11-7. 2004
  9. ncbi request reprint Delayed presentation and late testing for HIV: demographic and behavioral risk factors in a multicenter study in Italy
    Enrico Girardi
    Dipartimento di Epidemiologia, INMI Lazzaro Spallanzani, Roma, Italy
    J Acquir Immune Defic Syndr 36:951-9. 2004
  10. ncbi request reprint Role of hepatitis C virus (HCV) viremia and HCV genotype in the immune recovery from highly active antiretroviral therapy in a cohort of antiretroviral-naive HIV-infected individuals
    Giorgio Antonucci
    National Institute of Infectious Diseases, L Spallanzani, Rome, Italy
    Clin Infect Dis 40:e101-9. 2005

Detail Information

Publications84

  1. pmc Response to M. tuberculosis selected RD1 peptides in Ugandan HIV-infected patients with smear positive pulmonary tuberculosis: a pilot study
    Delia Goletti
    Translational Research Unit, Department of Experimental Research, Istituto Nazionale Malattie Infettive Lazzaro Spallanzani IRCCS Rome, Italy
    BMC Infect Dis 8:11. 2008
    ..Objective of this study was to investigate the response to selected RD1 peptides in HIV-1-infected subjects with or without active TB in a country endemic for TB and to evaluate the change of this response over time...
  2. ncbi request reprint Epidemiological aspects of transmitted HIV drug resistance
    Enrico Girardi
    Department of Epidemiology, National Institute of Infectious Diseases L Spallanzani, IRCCS, Rome, Italy
    Scand J Infect Dis Suppl 106:17-20. 2003
    ....
  3. pmc Isoniazid prophylaxis differently modulates T-cell responses to RD1-epitopes in contacts recently exposed to Mycobacterium tuberculosis: a pilot study
    Delia Goletti
    Translational Research Unit, Department of Experimental Research, Istituto Nazionale Malattie Infettive Lazzaro Spallanzani, IRCCS Rome, Italy
    Respir Res 8:5. 2007
    ....
  4. pmc Characterization of the patterns of drug-resistance mutations in newly diagnosed HIV-1 infected patients naïve to the antiretroviral drugs
    Claudia Alteri
    Department of Experimental Medicine and Biochemical Sciences, University of Tor Vergata Rome, Italy
    BMC Infect Dis 9:111. 2009
    ..This study is aimed to assess the prevalence and the patterns of the mutations recently associated with transmitted drug resistance in the reverse transcriptase (RT) and in protease (PR) of HIV-1...
  5. ncbi request reprint Trends in HIV prevalence among pregnant women in Italy, 1994 to 2002
    Enrico Girardi
    Dipartimento di Epidemiologia, Istituto Nazionale per le Malattie Infettive L Spallanzani IRCCS, Via Portuense 292, 00149 Rome, Italy
    J Acquir Immune Defic Syndr 41:361-4. 2006
    ..The aim of the study was to analyze the trends in HIV prevalence among childbearing women through unlinked anonymous testing of newborns...
  6. ncbi request reprint Incidence of Tuberculosis among HIV-infected patients receiving highly active antiretroviral therapy in Europe and North America
    Enrico Girardi
    Dipartimento di Epidemiologia, Istituto Nazionale per le Malattie Infettive L Spallanzani IRCCS, Via Portuense 292, 00149 Rome, Italy
    Clin Infect Dis 41:1772-82. 2005
    ..We obtained estimates of the incidence of tuberculosis (TB) among patients receiving HAART and identified determinants of the incidence...
  7. ncbi request reprint Late diagnosis of HIV infection: epidemiological features, consequences and strategies to encourage earlier testing
    Enrico Girardi
    UOC Epidemiologia Clinica, Istituto Nazionale per le Malattie Infettive L Spallanzani IRCCS, Rome, Italy
    J Acquir Immune Defic Syndr 46:S3-8. 2007
    ..This review summarizes recent evidence on the epidemiology of late presentation and its impact on clinical progression, and describes several key strategies that may encourage earlier diagnosis...
  8. ncbi request reprint Tuberculosis in HIV-infected persons in the context of wide availability of highly active antiretroviral therapy
    E Girardi
    Dipartimento di Epidemiologia, Istituto Nazionale per le Malattie Infettive L Spallanzani IRCCS, Rome, Italy
    Eur Respir J 24:11-7. 2004
    ..However, a significant proportion of cases occur in patients who are on antiretroviral treatment...
  9. ncbi request reprint Delayed presentation and late testing for HIV: demographic and behavioral risk factors in a multicenter study in Italy
    Enrico Girardi
    Dipartimento di Epidemiologia, INMI Lazzaro Spallanzani, Roma, Italy
    J Acquir Immune Defic Syndr 36:951-9. 2004
    ..42) reduced the odds of delayed presentation. Interventions aimed at promoting timely access to care of HIV-infected persons should consider differentiated programs for delayed presentation and late testing...
  10. ncbi request reprint Role of hepatitis C virus (HCV) viremia and HCV genotype in the immune recovery from highly active antiretroviral therapy in a cohort of antiretroviral-naive HIV-infected individuals
    Giorgio Antonucci
    National Institute of Infectious Diseases, L Spallanzani, Rome, Italy
    Clin Infect Dis 40:e101-9. 2005
    ..We also aimed to assess whether the response to HAART in these patients varied according to HCV genotype...
  11. ncbi request reprint The effect of age on response to therapy with peginterferon alpha plus ribavirin in a cohort of patients with chronic HCV hepatitis including subjects older than 65 yr
    Giorgio Antonucci
    Clinical Department of Infectious Disease, National Institute for Infectious Disease, L Spallanzani, Rome, Italy
    Am J Gastroenterol 102:1383-91. 2007
    ..This study was set up to evaluate the effect of age on the treatment of chronic HCV hepatitis with peginterferon alpha plus ribavirin...
  12. ncbi request reprint Effect of suppressing HIV viremia on the HIV progression of patients undergoing a genotype resistance test after treatment failure
    M Zaccarelli
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, Via Portuense 292, 00149, Rome, Italy
    Infection 37:203-9. 2009
    ..To assess the role of viral suppression on clinical progression following a genotypic resistance test (GRT), we have examined a database on patients failing to respond to combined antiretroviral therapy (cART)...
  13. pmc Impact of previous ART and of ART initiation on outcome of HIV-associated tuberculosis
    Enrico Girardi
    Clinical Epidemiology Unit, Department of Epidemiology and Clinical Department, National Institute for Infectious Diseases L Spallanzani, Via Portuense 292, 00149 Rome, Italy
    Clin Dev Immunol 2012:931325. 2012
    ..To date, however, limited data on tuberculosis treatment outcomes among coinfected patients who are not ART-naive at the time of tuberculosis diagnosis are available...
  14. doi request reprint Monophyletic outbreak of Hepatitis A involving HIV-infected men who have sex with men, Rome, Italy 2008-2009
    Licia Bordi
    Laboratory of Virology, National Institute for Infectious Diseases L Spallanzani, 292 Via Portuense, Rome, Italy
    J Clin Virol 54:26-9. 2012
    ..From July 2008 through January 2010, 162 HAV infections were diagnosed at National Institute for Infectious Diseases, Rome, Italy, with high male-to-female ratio (M:F=7.5)...
  15. doi request reprint Impaired CD4 T-cell count response to combined antiretroviral therapy in antiretroviral-naive HIV-infected patients presenting with tuberculosis as AIDS-defining condition
    Antonella Cingolani
    Catholic University, Roma, Italy
    Clin Infect Dis 54:853-61. 2012
    ..The impact of human immunodeficiency virus (HIV)-associated tuberculosis on CD4 T-cell count response to combined antiretroviral therapy (cART) is poorly investigated...
  16. ncbi request reprint Coinfection with hepatitis viruses and outcome of initial antiretroviral regimens in previously naive HIV-infected subjects
    Andrea De Luca
    Institute of Clinical Infectious Diseases, Catholic University of the Sacred Heart, Rome, Italy
    Arch Intern Med 162:2125-32. 2002
    ..The effect of chronic coinfection with hepatitis viruses on the response to therapy against human immunodeficiency virus 1 (HIV-1) remains debated...
  17. ncbi request reprint IFN-gamma, but not IP-10, MCP-2 or IL-2 response to RD1 selected peptides associates to active tuberculosis
    Delia Goletti
    Translational Research Unit, Department of Epidemiology and Preclinical Research, L Spallanzani National Institute for Infectious Diseases INMI, Via Portuense 292, Rome, Italy
    J Infect 61:133-43. 2010
    ....
  18. ncbi request reprint Temporal trend and characteristics of recent HIV-1 infections: application of an algorithm for the identification of recently acquired HIV-1 infections among newly diagnosed individuals over a 10-year period
    Nicoletta Orchi
    Department of Epidemiology Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy
    New Microbiol 36:353-61. 2013
    ..49, [CI 0.37-0.66]). By the application of our algorithm we could characterize the pattern of ongoing HIV transmission, identifying groups needing more urgent prevention programs...
  19. ncbi request reprint Use of a T cell-based assay for monitoring efficacy of antituberculosis therapy
    Stefania Carrara
    Translational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    Clin Infect Dis 38:754-6. 2004
    ..On the basis of these data, we conclude that our assay is a useful tool in monitoring the efficacy of antituberculosis therapy...
  20. ncbi request reprint Response to HAART and GB virus type C coinfection in a cohort of antiretroviral-naive HIV-infected individuals
    Giorgio Antonucci
    National Institute of Infectious Diseases, L Spallanzani, Roma, Italy
    Antivir Ther 10:109-17. 2005
    ..These results suggest that GBV-C coinfection may play a role in determining the rate of HIV rebound possibly by competing with HIV replication after HIV load has been successfully suppressed by HAART...
  21. doi request reprint IFNγ/TNFα specific-cells and effector memory phenotype associate with active tuberculosis
    Elisa Petruccioli
    Translational Research Unit, Department of Epidemiology and Preclinical Research, L Spallanzani National Institute for Infectious Diseases INMI, IRCCS, Via Portuense 292, 00149 Rome, Italy
    J Infect 66:475-86. 2013
    ..To assess the specificity of these findings, we evaluated the response to cytomegalovirus (CMV), an unrelated antigen...
  22. pmc Accuracy of immunodiagnostic tests for active tuberculosis using single and combined results: a multicenter TBNET-Study
    Delia Goletti
    Translational Research Unit, Department of Epidemiology and Preclinical Research, National Institute for Infectious Diseases INMI L Spallanzani, IRCCS, Rome, Italy
    PLoS ONE 3:e3417. 2008
    ..Carnegie, Australia) and T-SPOT.TB (Oxfordimmunotec, Abingdon, UK)...
  23. pmc Lack of implementation of Hepatitis B Virus (HBV) vaccination policy in household contacts of HBV carriers in Italy
    Paola Scognamiglio
    Department of Epidemiology and Preclinical Research, Istituto Nazionale per le Malattie Infettive, L Spallanzani IRCCS, Rome, Italy
    BMC Infect Dis 9:86. 2009
    ....
  24. pmc Comparison of LCx with other current viral load assays for detecting and quantifying human immunodeficiency virus type 1 RNA in patients infected with the circulating recombinant form A/G (CRF02)
    Alessandra Amendola
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    J Clin Microbiol 42:811-5. 2004
    ..LCx showed significant but low correlation with the other methods. Values of <2.60 log(10) cp/ml were observed in 29.6% of specimens with LCx and in only 14.8% with bDNA and PCR, suggesting suboptimal performance of LCx with CRF02...
  25. ncbi request reprint Epidemiological aspects of major opportunistic infections of the respiratory tract in persons with AIDS: Europe, 1993-2000
    Diego Serraino
    Department of Epidemiology, National Institute for Infectious Diseases, IRCCS, Rome, Italy
    AIDS 17:2109-16. 2003
    ..To describe the epidemiology of Pneumocystis carinii pneumonia (PCP), pulmonary tuberculosis (PTB) and recurrent bacterial pneumonia (RBP) as AIDS-defining illnesses (ADI) in Europe...
  26. pmc Methylated HBHA produced in M. smegmatis discriminates between active and non-active tuberculosis disease among RD1-responders
    Giovanni Delogu
    Istituto di Microbiologia, Universita Cattolica del Sacro Cuore, Roma, Italy
    PLoS ONE 6:e18315. 2011
    ..Therefore, the aim of the present study was to evaluate the IFN-γ response to methylated HBHA of Mtb produced in M. smegmatis (rHBHAms) in individuals at different stages of TB who scored positive to QFT-IT...
  27. ncbi request reprint Behavioral correlates of adherence to antiretroviral therapy
    Maria Stella Aloisi
    Dipartimento di Epidemiologia, Istituto Nazionale per le Malattie Infettive L Spallanzani IRCCS, Rome, Italy
    J Acquir Immune Defic Syndr 31:S145-8. 2002
    ..The data do not support the hypothesis that among HIV-infected person on antiretroviral therapy, poor adherence is associated with high-risk sexual behaviors that may further spread the infection...
  28. doi request reprint IP-10 is an additional marker for tuberculosis (TB) detection in HIV-infected persons in a low-TB endemic country
    Valentina Vanini
    Translational Research Unit, Department of Epidemiology and Preclinical Research, L Spallanzani National Institute for Infectious Diseases INMI, IRCCS, Via Portuense 292, 00149 Rome, Italy
    J Infect 65:49-59. 2012
    ..To investigate this uncertainty, likely due to India being highly endemic for TB, and to better identify TB correlates, we evaluated the IP-10-based assay in HIV-infected subjects in Italy, a low-TB endemic country...
  29. doi request reprint High HIV prevalence in male patients with acute hepatitis A in the Rome metropolitan area, Italy 2002-2008
    Enrico Girardi
    National Institute for Infectious Diseases L Spallanzani, Rome, Italy
    J Hepatol 54:1102-6. 2011
    ..However, the prevalence of HIV infection in patients affected by hepatitis A has not been extensively studied and hepatitis A is not considered as an indicator disease for routine HIV testing...
  30. doi request reprint Structural modifications induced by specific HIV-1 protease-compensatory mutations have an impact on the virological response to a first-line lopinavir/ritonavir-containing regimen
    Claudia Alteri
    Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy
    J Antimicrob Chemother 68:2205-9. 2013
    ....
  31. ncbi request reprint HVR-1 quasispecies modifications occur early and are correlated to initial but not sustained response in HCV-infected patients treated with pegylated- or standard-interferon and ribavirin
    Isabella Abbate
    Department of Virology, National Institute for Infectious Diseases L Spallanzani, Rome, Italy
    J Hepatol 40:831-6. 2004
    ..HVR-1 quasispecies composition and evolution were investigated in patients chronically infected with genotype 1b HCV, treated with PEG-IFN alpha 2b or STD-IFN alpha 2b plus RBV...
  32. ncbi request reprint Underevaluation of HIV-1 plasma viral load by a commercially available assay in a cluster of patients infected with HIV-1 A/G circulating recombinant form (CRF02)
    Alessandra Amendola
    Laboratory of Virology, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Via Portuense 292, 00149 Rome, Italy
    J Acquir Immune Defic Syndr 31:488-94. 2002
    ..These results are potentially important as global distribution of new HIV-1 subtypes is expanding, and recombinant strains, particularly CRF02, are emerging and becoming highly prevalent...
  33. pmc Determinants of access to experimental antiretroviral drugs in an Italian cohort of patients with HIV: a multilevel analysis
    Enrico Girardi
    Department of Epidemiology and Preclinical Research, National Institute for Infectious Diseases L, Spallanzani, IRCCS, Via Portuense 292, 00149, Rome, Italy
    BMC Health Serv Res 12:38. 2012
    ..Identification of the determinants of access to investigational drugs is important to promote equity and scientific validity in clinical research. We aimed to analyze factors associated with the use of experimental antiretrovirals in Italy...
  34. pmc HIV incidence estimate combining HIV/AIDS surveillance, testing history information and HIV test to identify recent infections in Lazio, Italy
    Alessia Mammone
    Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Rome, Italy
    BMC Infect Dis 12:65. 2012
    ..in 2008, that accounts for the effect of testing practices on the number of persons detected as recently infected...
  35. pmc Higher frequency of T-cell response to M. tuberculosis latency antigen Rv2628 at the site of active tuberculosis disease than in peripheral blood
    Teresa Chiacchio
    Translational Research Unit, Department of Epidemiology and Preclinical Research, L Spallanzani National Institute for Infectious Diseases INMI, IRCCS, Rome, Italy
    PLoS ONE 6:e27539. 2011
    ....
  36. ncbi request reprint Effective highly active antiretroviral therapy in patients with primary HIV-1 infection prevents the evolution of the avidity of HIV-1-specific antibodies
    Marina Selleri
    Laboratorio di Virologia, Istituto Nazionale per le Malattie Infettive L Spallanzani, Rome, Italy
    J Acquir Immune Defic Syndr 46:145-50. 2007
    ..To evaluate if the administration of highly active antiretroviral therapy (HAART) during primary HIV infection (PHI) may affect the antibody avidity evolution...
  37. ncbi request reprint Impact of hepatitis C virus infection on lifestyle
    Paola Scognamiglio
    Istituto Nazionale per le Malattie Infettive, L Spallanzani IRCCS, Via Portuense 292, Roma 00149, Italy
    World J Gastroenterol 13:2722-6. 2007
    ..To evaluate the impact of the diagnosis of hepatitis C infection on lifestyle habits such as smoking, drinking, sports activity and diet...
  38. ncbi request reprint [Time trends in infectious disease mortality in Italy: 1969-1999]
    Diego Serraino
    Dipartimento di Epidemiologia, Istituto nazionale perle malattie infettive L Spallanzani, IRCCS, Roma
    Epidemiol Prev 28:322-9. 2004
    ..To describe the global impact of infectious diseases on mortality in Italy from 1969 to 1999...
  39. ncbi request reprint Region of difference 1 antigen-specific CD4+ memory T cells correlate with a favorable outcome of tuberculosis
    Delia Goletti
    Second Division of Infectious Diseases of the Health Department, Department of Experimental Research, National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    J Infect Dis 194:984-92. 2006
    ....
  40. doi request reprint Expression levels of TLRs involved in viral recognition in PBMCs from HIV-1-infected patients failing antiretroviral therapy
    Carolina Scagnolari
    Virology Section, Department of Experimental Medicine, Policlinico Umberto I, Sapienza University, Viale di Porta Tiburtina 28, Rome, Italy
    Intervirology 52:107-14. 2009
    ..The aim of this study was to evaluate whether gene expression of Toll-like receptor (TLR)-3, TLR4, TLR7 and TLR9 was impaired in patients with chronic HIV-1 infection who were failing to respond to antiretroviral therapy...
  41. pmc The potential impact of routine testing of individuals with HIV indicator diseases in order to prevent late HIV diagnosis
    Paola Scognamiglio
    National Institute for Infectious Diseases L, Spallanzani IRCCS, Via Portuense 292, Rome 00149, Italy
    BMC Infect Dis 13:473. 2013
    ....
  42. pmc Hepatitis E virus genotype 4 outbreak, Italy, 2011
    Anna R Garbuglia
    Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy
    Emerg Infect Dis 19:110-4. 2013
    ..Detection of this genotype in Italy parallels findings in other countries in Europe, signaling the possible spread of strains new to Western countries...
  43. pmc Improvement of tuberculosis laboratory capacity on Pemba Island, Zanzibar: a health cooperation project
    Maria G Paglia
    Microbiology Laboratory, Epidemiology and Clinical Departments, National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    PLoS ONE 7:e44109. 2012
    ..An advanced TB laboratory can represent a low cost solution to strengthen the TB diagnosis, to provide capacity building and mid-term sustainability...
  44. doi request reprint Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages
    Elisa Petruccioli
    Translational Research Unit, University of Rome Tor Vergata, Rome, Italy
    J Infect Dis 205:1425-35. 2012
    ..tuberculosis-mediated autophagy. The aim of this study was to evaluate the impact of M. tuberculosis on autophagy in human primary macrophages and the role of specific T cells in this process...
  45. pmc New tools for detecting latent tuberculosis infection: evaluation of RD1-specific long-term response
    Ornella Butera
    Department of Epidemiology and Preclinical Research, L Spallanzani National institute for infectious diseases, IRCCS, Rome, Italy
    BMC Infect Dis 9:182. 2009
    ....
  46. ncbi request reprint HIV-1 DNA burden dynamics in CD4 T cells and monocytes in patients undergoing a transient therapy interruption
    Anna Rosa Garbuglia
    National Institute for Infectious Diseases L Spallanzani I R C C S, Rome, Italy
    J Med Virol 74:373-81. 2004
    ..Repopulation by HIV these cells after TTI is temporary, and no significant changes of HIV-1 DNA burden were observed after ART resumption respect to pre-TTI period...
  47. doi request reprint Characteristics and behaviors in a sample of patients unaware of their infection until AIDS diagnosis in Italy: a cross-sectional study
    Anna Colucci
    Department of Infectious Parasitic and Immune mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    AIDS Care 23:1067-75. 2011
    ..Individuals enrolled seem to have a low perception of risk, they do not undergo HIV testing, and consequently miss the opportunity of early diagnosis...
  48. pmc IP-10 detection in urine is associated with lung diseases
    Angela Cannas
    Department of Epidemiology and Preclinical Research, L Spallanzani National Institute for Infectious Diseases INMI, Rome, Italy
    BMC Infect Dis 10:333. 2010
    ..In a subgroup, the evaluation was also performed during TB treatment and at therapy completion. Patients with lung diseases other than TB, and healthy subjects were also enrolled...
  49. ncbi request reprint Molecular characterization of hepatitis A outbreak in the province of Rome, Lazio region, Italy, January-July 2013
    Maria R Capobianchi
    Laboratory of Virology, National Institute for Infectious Diseases L Spallanzani, Via Portuense 292, 00149 Rome, Italy Electronic address
    Microbes Infect 16:362-6. 2014
    ..This strain is also very similar to previous isolates from Venezuela. ..
  50. ncbi request reprint Using a database of HIV patients undergoing genotypic resistance test after HAART failure to understand the dynamics of M184V mutation
    Mauro Zaccarelli
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    Antivir Ther 8:51-6. 2003
    ..M184V/I mutation is associated with high-level phenotypic resistance to lamivudine (3TC). The aim of the present analysis was to correlate the time of appearance/disappearance of M184V/I with duration of 3TC treatment...
  51. pmc Identification of early secretory antigen target-6 epitopes for the immunodiagnosis of active tuberculosis
    Donatella Vincenti
    Translational Research Unit of the National Institute for Infectious Diseases, Lazzaro Spallanzani, Rome, Italy
    Mol Med 9:105-11. 2003
    ..Thus, high T-cell response frequencies to ESAT-6 peptides are present only during active TB and can be used to discriminate between active and latent forms of infection...
  52. ncbi request reprint High incidence of tuberculin skin test conversion among HIV-infected individuals who have a favourable immunological response to highly active antiretroviral therapy
    Enrico Girardi
    Dipartimento di Epidemiologia and Dipartimento Clinico, Istituto Nazionale per le Malattie Infettive L Spallanzani, IRCCS, Rome, Italy
    AIDS 16:1976-9. 2002
  53. doi request reprint Strengthening tuberculosis diagnosis in a low-resource setting: experience learned in Dodoma, Tanzania
    Angela Cannas
    National Institute for Infectious Diseases INMI L Spallanzani, Rome, Italy
    J Infect Dev Ctries 7:676-9. 2013
    ..Diagnosing tuberculosis in low-resource settings mostly relies on sputum smear microscopy. Improvement through capacity building is a priority. This project aimed to strengthen tuberculosis diagnosis at an intermediate level laboratory...
  54. pmc Cystic echinococcosis in a single tertiary care center in Rome, Italy
    Linda Petrone
    Translational Research Unit, Department of Epidemiology and Preclinical Research, L Spallanzani National Institute for Infectious Diseases INMI, IRCCS, Via Portuense 292, 00149 Rome, Italy
    Biomed Res Int 2013:978146. 2013
    ..Cystic echinococcosis (CE) is a chronic, clinically complex, and neglected disease. Its prevalence in Italy, a country of medium to high endemicity, remains poorly defined, as notification has long ceased to be mandatory...
  55. ncbi request reprint The 2005 Italian Quality Control Study for the evaluation of CD4 cells in centers involved in the treatment of HIV type 1 patients
    Federico Martini
    National Institute for Infectious Diseases Lazzaro Spallanzani I R C C S, Rome, Italy
    AIDS Res Hum Retroviruses 23:777-81. 2007
    ..Overall, our data suggest that most Italian laboratories provide reliable and reproducible results in evaluating CD4 T cells in HIV(+) samples...
  56. doi request reprint 'Sentinel' mutations in standard population sequencing can predict the presence of HIV-1 reverse transcriptase major mutations detectable only by ultra-deep pyrosequencing
    Claudia Alteri
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    J Antimicrob Chemother 66:2615-23. 2011
    ....
  57. pmc Detection of Pulmonary tuberculosis: comparing MR imaging with HRCT
    Elisa Busi Rizzi
    Diagnostic Department, Radiology, L, Spallanzani National Institute for Infectious Diseases, Rome, Italy
    BMC Infect Dis 11:243. 2011
    ..Therefore, the purpose of our study was to compare MRI with high resolution CT (HRCT) for assessing pulmonary tuberculosis...
  58. pmc Is IP-10 an accurate marker for detecting M. tuberculosis-specific response in HIV-infected persons?
    Delia Goletti
    Translational Research Unit, Department of Epidemiology and Preclinical Research, Lazzaro Spallanzani National Institute for Infectious Diseases INMI, Rome, Italy
    PLoS ONE 5:e12577. 2010
    ....
  59. ncbi request reprint Cross-resistance among nonnucleoside reverse transcriptase inhibitors limits recycling efavirenz after nevirapine failure
    Andrea Antinori
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, 00149 Rome, Italy
    AIDS Res Hum Retroviruses 18:835-8. 2002
    ..No virological response was observed in six patients harboring a single Y181C/I mutation. On the basis of the present data, sequential use of NNRTIs should be avoided in the management of treatment failure...
  60. pmc IP-10 response to RD1 antigens might be a useful biomarker for monitoring tuberculosis therapy
    Basirudeen Syed Ahamed Kabeer
    Department of Immunology, Tuberculosis Research Centre ICMR, Tamil Nadu, Chennai, India
    BMC Infect Dis 11:135. 2011
    ....
  61. pmc Tuberculosis case finding based on symptom screening among immigrants, refugees and asylum seekers in Rome
    Monica Sañé Schepisi
    Clinical Epidemiology Unit, Department of Epidemiology and Preclinical Research, National Institute for Infectious Diseases, IRCCS L, Spallanzani, Rome, Italy
    BMC Public Health 13:872. 2013
    ..We designed a study to assess adherence to and yield of a tuberculosis screening programme based on symptom screening conducted at primary care centres for regular and irregular immigrants and refugees/asylum seekers...
  62. ncbi request reprint Cavitary pulmonary tuberculosis HIV-related
    Elisa Busi Rizzi
    Department of Radiology, National Institute for Infectious Diseases, Lazzaro Spallanzani, Servizio di Radiologia, Via Portuense 292, 00149 Roma, Italy
    Eur J Radiol 52:170-4. 2004
    ..We have hypothesised that the so called "atypical" radiographic features could be due to a greater proportion of primary TB among these patients, representing the typical appearance of primary radiological pattern...
  63. pmc Timing of antiretroviral therapy initiation after a first AIDS-defining event: temporal changes in clinical attitudes in the ICONA cohort
    Antonella Cingolani
    Department of Public Health, Institute of Infectious Diseases, Catholic University, Roma, Italy
    PLoS ONE 9:e89861. 2014
    ..Objectives of this study were to evaluate if in patients diagnosed with ADE the time to ART initiation may vary according to year of diagnosis and type of ADE...
  64. pmc Circulation of HIV-1 CRF02_AG among MSM population in central Italy: a molecular epidemiology-based study
    Massimo Giuliani
    Department of Infectious Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Rome, Italy HIV AIDS Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy
    Biomed Res Int 2013:810617. 2013
    ..The evolutionary and demographic history of the circular recombinant form CRF02_AG in a selected retrospective group of HIV-1 infected men who have sex with men (MSM) resident in Central Italy was investigated...
  65. pmc Simple and reliable method for detection and genotyping of hepatitis C virus RNA in dried blood spots stored at room temperature
    Mariacarmela Solmone
    National Institute for Infectious Diseases L Spallanzani, IRCCS, Rome, Italy
    J Clin Microbiol 40:3512-4. 2002
    ....
  66. ncbi request reprint Pharmacodynamics of interferon beta in multiple sclerosis patients with or without serum neutralizing antibodies
    Carolina Scagnolari
    Dept of Experimental Medicine Virology Section, La Sapienza University, Rome, Italy
    J Neurol 254:597-604. 2007
    ..In summary, our findings confirm that NABs affect absolute concentrations of IFN-beta induced markers and suggest that such an effect occurs in a titer-dependent manner...
  67. ncbi request reprint [Epidemiology and control of tuberculosis in Italy]
    Enrico Girardi
    Dipartimento di Epidemiologia e Ricerca Preclinica, Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Roma, Italy
    G Ital Med Lav Ergon 32:256-9. 2010
    ..Upstream social determinants of tuberculosis need also to be addressed in order to move towards the goal of tuberculosis elimination...
  68. ncbi request reprint Do IFN-γ-release assays predict the risk of TB? New evidence from a study on patients with silicosis
    Enrico Girardi
    Department of Epidemiology and Pre clinical Research, National Institute for Infectious Diseases L Spallanzani, Via Portuense 292, 00149 Roma, Italy
    Expert Rev Anti Infect Ther 8:1105-8. 2010
    ..This study provides further support to the guidelines from public health agencies recommending the use of IGRAs in place of or in addition to TST. Several issues regarding their optimal use, however, remain open to debate...
  69. pmc Implications of storing urinary DNA from different populations for molecular analyses
    Angela Cannas
    National Institute for Infectious Diseases L Spallanzani, IRCCS, Roma, Italy
    PLoS ONE 4:e6985. 2009
    ..Storage of urine prior to analysis, whether due to home collection or bio-banking, is increasingly advocated yet no best practice has emerged. Here, we examined the stability of DNA in stored urine in two populations over 28 days...
  70. ncbi request reprint The combination of a smoking cessation programme with rehabilitation increases stop-smoking rate
    Gregorino Paone
    Department of Cardiovascular and Respiratory Sciences, University of Rome La Sapienza, S Camillo Forlanini Hospital, Rome, Italy
    J Rehabil Med 40:672-7. 2008
    ..A parallel group study to investigate the effectiveness of a smoking cessation programme performed during routine rehabilitation practice for outpatients...
  71. ncbi request reprint Monophyletic HIV type 1 CRF02-AG in a nosocomial outbreak in Benghazi, Libya
    Ubaldo Visco-Comandini
    National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy
    AIDS Res Hum Retroviruses 18:727-32. 2002
    ..The data thus suggest a highly contagious nosocomial spread of HIV-1 infection and possibly transmission of the virus from child to mother during breastfeeding in connection with primary HIV-1 infection...
  72. ncbi request reprint Evolution of HVR-1 quasispecies after 1-year treatment in HIV/HCV-coinfected patients according to the pattern of response to highly active antiretroviral therapy
    Mariacarmela Solmone
    National Institute of Infectious Diseases L Spallanzani, Rome
    Antivir Ther 11:87-94. 2006
    ..On the whole, these findings suggest that, in patients undergoing HAART, the extent of HCV variability and the evolution of HVR-1 quasispecies is influenced by the pattern of response to antiretroviral therapy...
  73. doi request reprint Epidemiology of viral hepatitis infections in an area of southern Italy with high incidence rates of liver cancer
    Mario Fusco
    Registro Tumori della Regione Campania, ASL NA4 Brusciano, Naples, Italy
    Eur J Cancer 44:847-53. 2008
    ..Sexual intercourse with HCV-positive individuals conveyed a 3-fold higher risk of HCV infection. This study quantified the spread of HCV and HBV in the population of southern Italy heavily affected by liver cancer...
  74. ncbi request reprint Partnership of HIV-infected women and health status
    Maria Stella Aloisi
    J Acquir Immune Defic Syndr 39:502-3. 2005
  75. ncbi request reprint Effect of hepatitis C virus genotype on CD4+ T cell count in a cohort of antiretroviral-naive HIV-1-infected individuals
    Giorgio Antonucci
    J Infect Dis 192:703-4; author reply 704-5. 2005
  76. ncbi request reprint Thymidine kinase and deoxycytidine kinase activity in mononuclear cells from antiretroviral-naive HIV-infected patients
    Ombretta Turriziani
    Department of Experimental Medicine and Pathology, Virology Section, University La Sapienza, 28 00185 Rome, Italy
    AIDS 19:473-9. 2005
    ....
  77. doi request reprint T cell responses to commercial mycobacterium tuberculosis-specific antigens in HIV-infected patients
    Delia Goletti
    Clin Infect Dis 45:1652-4. 2007
  78. ncbi request reprint Access to antiretroviral treatment, incidence of sustained therapy interruptions, and risk of clinical events according to sex: evidence from the I.Co.N.A. Study
    Rita Murri
    Department of Infectious Diseases, Catholic University of Rome, Italy
    J Acquir Immune Defic Syndr 34:184-90. 2003
    ..3). Clinical progression was observed in 53 women (22.6%) and 137 men (23.4%; P = 0.56). Risk of developing a clinical event was found to be no different between women and men (relative hazard = 0.84, 95% CI: 0.56-1.26; P = 0.40)...
  79. doi request reprint Extensively drug-resistant tuberculosis is worse than multidrug-resistant tuberculosis: different methodology and settings, same results
    Giovanni Battista Migliori
    Clin Infect Dis 46:958-9. 2008
  80. pmc Selected RD1 peptides for active tuberculosis diagnosis: comparison of a gamma interferon whole-blood enzyme-linked immunosorbent assay and an enzyme-linked immunospot assay
    Delia Goletti
    Laboratorio di collegamento tra ricerca di base e clinica, Padiglione Del Vecchio, Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, I R C C S, Roma 00149, Italy
    Clin Diagn Lab Immunol 12:1311-6. 2005
    ..Moreover, our assay appears more specific for A-TB diagnosis than QuantiFERON-TB Gold, and thus it may represent a complementary tool for A-TB diagnosis for routine use in clinical laboratories...
  81. ncbi request reprint Possible child-to-mother transmission of HIV by breastfeeding
    Ubaldo Visco-Comandini
    JAMA 294:2301-2. 2005
  82. ncbi request reprint Should individuals who are tuberculin skin test negative and positive to RD1-IFN-gamma assay receive preventive therapy?
    Enrico Girardi
    Am J Respir Crit Care Med 175:198-199; author reply 199-200. 2007
  83. pmc Extensively drug-resistant tuberculosis, Italy and Germany
    Giovanni Battista Migliori
    Emerg Infect Dis 13:780-2. 2007
  84. ncbi request reprint Consent policies and rates of HIV testing
    Enrico Girardi
    JAMA 297:2478-9; author reply 2479. 2007