Guido Frumento

Summary

Affiliation: National Cancer Research Institute
Country: Italy

Publications

  1. pmc Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase
    Guido Frumento
    Immunogenetics Laboratory, National Cancer Research Institute, University of Genoa, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    J Exp Med 196:459-68. 2002
  2. ncbi request reprint Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors
    Sebastian Giebel
    Department of Haematology and Bone Marrow Transplantation, Silesian Medical Academy, Katowice, Poland
    Blood 102:814-9. 2003
  3. ncbi request reprint The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function
    Mariella Della Chiesa
    DIMS Dipartimento di Medicina Sperimentale, Universita di Genova, Genova, Italy
    Blood 108:4118-25. 2006
  4. doi request reprint Natural killer cells infiltrating human nonsmall-cell lung cancer are enriched in CD56 bright CD16(-) cells and display an impaired capability to kill tumor cells
    Paolo Carrega
    Department of Experimental Medicine, University of Genoa, Italy
    Cancer 112:863-75. 2008
  5. doi request reprint Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression
    Rita Rotondo
    Department of Translational Oncology, National Institute for Cancer Research, Genoa, Italy
    Int J Cancer 123:1108-16. 2008
  6. ncbi request reprint Targeting tumor-related immunosuppression for cancer immunotherapy
    Guido Frumento
    Istituto Nazionale per la Ricerca sul Cancro, C o CBA Largo R Benzi 10, 16132 Genoa, Italy
    Endocr Metab Immune Disord Drug Targets 6:233-7. 2006
  7. ncbi request reprint A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation
    Elisabetta Zino
    HLA Tissue Typing Laboratory, Immunohematology and Transfusion Medicine Service, San Raffaele Telethon Institue for Gene Therapy, Cancer Immunotherapy and Gene Therapy Program, Istituto Scientifico H S Raffaele, Via Olgettina 60, I 20132 Milan, Italy
    Blood 103:1417-24. 2004
  8. pmc Eosinophil granulocytes account for indoleamine 2,3-dioxygenase-mediated immune escape in human non-small cell lung cancer
    Simonetta Astigiano
    Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Neoplasia 7:390-6. 2005

Collaborators

  • Alessandro Moretta
  • Lorenzo Moretta
  • Guido Ferlazzo
  • Sebastian Giebel
  • Barbara Morandi
  • Roberta Costa
  • Simonetta Astigiano
  • Rita Rotondo
  • Paolo Carrega
  • Luca Mastracci
  • Giovanni Battista Ratto
  • Mariella Della Chiesa
  • Elisabetta Zino
  • Tiziana Piazza
  • Alfredo Cesario
  • Silvano Ferrini
  • Michela Cassanello
  • Giuseppe Forte
  • Gaia Barisione
  • Giovanni B Ratto
  • Francesco Grossi
  • Giuseppe Altavilla
  • Maria Cristina Mingari
  • Marina Fabbi
  • Maria P Sormani
  • Claudia Cantoni
  • Massimo Vitale
  • Mirna Balsamo
  • Simona Carlomagno
  • Romana Conte
  • Antonella D'Agostino
  • Giovanni Melioli
  • Anna Maria Parodi
  • Francesca Bonifazi
  • Giuseppe Bandini
  • Franco Locatelli
  • Jane Apperley
  • Andrea Bacigalupo
  • Silvano Rossini
  • Katharina Fleischhauer
  • Ruhena Sergeant
  • Paolo Servida
  • Simona Di Terlizzi
  • Maria Pia Sormani
  • Daniela Lisini
  • Benedetta Mazzi
  • Claudio Bordignon
  • Chiara Bonini
  • Francesca Ficara
  • Edoardo Lanino
  • Miryam Martinetti
  • Andrea Bontadini
  • Giovanni Battista Ferrara
  • Sarah Marktel
  • Fabio Ciceri

Detail Information

Publications8

  1. pmc Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase
    Guido Frumento
    Immunogenetics Laboratory, National Cancer Research Institute, University of Genoa, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    J Exp Med 196:459-68. 2002
    ....
  2. ncbi request reprint Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors
    Sebastian Giebel
    Department of Haematology and Bone Marrow Transplantation, Silesian Medical Academy, Katowice, Poland
    Blood 102:814-9. 2003
    ..These data indicate that natural killer (NK) cell alloreactivity is associated with better outcome after URD-HSC transplantation when ATG is used as part of GVHD prophylaxis...
  3. ncbi request reprint The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function
    Mariella Della Chiesa
    DIMS Dipartimento di Medicina Sperimentale, Universita di Genova, Genova, Italy
    Blood 108:4118-25. 2006
    ..The effect of l-kynurenine, which is effective at both the transcriptional and the protein level, can be reverted, since NK cells were found to recover their functional competence after washing...
  4. doi request reprint Natural killer cells infiltrating human nonsmall-cell lung cancer are enriched in CD56 bright CD16(-) cells and display an impaired capability to kill tumor cells
    Paolo Carrega
    Department of Experimental Medicine, University of Genoa, Italy
    Cancer 112:863-75. 2008
    ..Despite natural killer (NK) cells being originally identified and named because of their ability to kill tumor cells in vitro, only limited information is available on NK cells infiltrating malignant tumors, especially in humans...
  5. doi request reprint Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression
    Rita Rotondo
    Department of Translational Oncology, National Institute for Cancer Research, Genoa, Italy
    Int J Cancer 123:1108-16. 2008
    ..Our results indicate that ARG2 is expressed in lung cancer, but it does not induce tumor immune escape and does not affect disease progression, most probably due to the lack of concomitant NOS expression...
  6. ncbi request reprint Targeting tumor-related immunosuppression for cancer immunotherapy
    Guido Frumento
    Istituto Nazionale per la Ricerca sul Cancro, C o CBA Largo R Benzi 10, 16132 Genoa, Italy
    Endocr Metab Immune Disord Drug Targets 6:233-7. 2006
    ..Also strategies aimed at blocking enzyme-based immune-suppressive mechanisms are suitable, as suggested by experimental evidences in mouse tumor models...
  7. ncbi request reprint A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation
    Elisabetta Zino
    HLA Tissue Typing Laboratory, Immunohematology and Transfusion Medicine Service, San Raffaele Telethon Institue for Gene Therapy, Cancer Immunotherapy and Gene Therapy Program, Istituto Scientifico H S Raffaele, Via Olgettina 60, I 20132 Milan, Italy
    Blood 103:1417-24. 2004
    ..64, P =.1). These data suggest that biologic characterization of in vivo alloreactivity can be a tool for definition of clinically relevant nonpermissive HLA mismatches for unrelated HSC transplantation...
  8. pmc Eosinophil granulocytes account for indoleamine 2,3-dioxygenase-mediated immune escape in human non-small cell lung cancer
    Simonetta Astigiano
    Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Neoplasia 7:390-6. 2005
    ..This finding suggests that the degree of IDO-positive infiltrate could be a prognostic marker in NSCLC...