Gian Maria Fimia

Summary

Affiliation: National Institute for Infectious Diseases
Country: Italy

Publications

  1. ncbi Unleashing the Ambra1-Beclin 1 complex from dynein chains: Ulk1 sets Ambra1 free to induce autophagy
    Gian Maria Fimia
    National Institute for Infectious Diseases IRCCS L Spallanzani, Rome, Italy
    Autophagy 7:115-7. 2011
  2. ncbi Autophagy protects cells from HCV-induced defects in lipid metabolism
    Tiziana Vescovo
    National Institute for Infectious Diseases IRCCS L Spallanzani, Rome, Italy
    Gastroenterology 142:644-653.e3. 2012
  3. ncbi ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells
    Alessandra Romagnoli
    Department of Epidemiology and Preclinical Research, National Institute for Infectious Diseases L Spallanzani, Rome, Italy
    Autophagy 8:1357-70. 2012
  4. ncbi Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
    Flavie Strappazzon
    Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, Rome, Italy
    EMBO J 30:1195-208. 2011
  5. ncbi EBV stimulates TLR- and autophagy-dependent pathways and impairs maturation in plasmacytoid dendritic cells: implications for viral immune escape
    Martina Severa
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Eur J Immunol 43:147-58. 2013
  6. ncbi Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages
    Elisa Petruccioli
    Translational Research Unit, University of Rome Tor Vergata, Rome, Italy
    J Infect Dis 205:1425-35. 2012
  7. ncbi Liver protein profiling in chronic hepatitis C: identification of potential predictive markers for interferon therapy outcome
    Ariel Basulto Perdomo
    National Institute for Infectious Diseases IRCCS L Spallanzani, Rome, Italy
    J Proteome Res 11:717-27. 2012
  8. ncbi Proteomic analysis of mitochondrial dysfunction in neurodegenerative diseases
    Carlo Rodolfo
    Laboratory of Development and Cell Biology, Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Expert Rev Proteomics 7:519-42. 2010
  9. ncbi Proteomic analysis reveals a major role for contact inhibition in the terminal differentiation of hepatocytes
    Carmine Mancone
    Laboratory of Gene Expression, National Institute for Infectious Diseases L Spallanzani IRCCS, Via Portuense 292, Rome, Italy
    J Hepatol 52:234-43. 2010
  10. ncbi Proteomic analysis identifies prohibitin down-regulation as a crucial event in the mitochondrial damage observed in HIV-infected patients
    Fabiola Ciccosanti
    National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy
    Antivir Ther 15:377-90. 2010

Collaborators

  • Tonino Alonzi
  • Francesco Cecconi
  • Giuseppe Ippolito
  • Delia Goletti
  • Giovanni Delogu
  • Eliana M Coccia
  • Enrico Girardi
  • Ornella Butera
  • Claudio Sette
  • Guido Kroemer
  • Andrea Antinori
  • Paola Matarrese
  • Martin Griffin
  • Paolo Ascenzi
  • Wilfried Bursch
  • Stefan Stamm
  • Mauro Piacentini
  • Marco Corazzari
  • Fabiola Ciccosanti
  • Alessandra Romagnoli
  • Ariel Basulto Perdomo
  • Carmine Mancone
  • Martina Severa
  • Elena Giacomini
  • Valerie Gafa
  • Elisa Petruccioli
  • Tiziana Vescovo
  • Oreste Lo Iacono
  • Marco Tripodi
  • Flavie Strappazzon
  • Laura Falasca
  • Simona Pedrotti
  • Carlo Rodolfo
  • Roberta Nardacci
  • Francesco Imperi
  • Manuela D'Eletto
  • Barbara Fazi
  • Pankaj Trivedi
  • Fabiana Rizzo
  • Eleni Anastasiadou
  • Manuela Pardini
  • Marilena P Etna
  • Roberto Pisa
  • Roland Brosch
  • Roxane Simeone
  • Nicola Daniele
  • Carmelo Garcia-Monzon
  • Claudio Angeletti
  • Angela Testa
  • Giorgio Antonucci
  • Maria Elena Remoli
  • Matteo Vietri-Rudan
  • Fulvio Florenzano
  • Francesca Nazio
  • Beth Levine
  • Silvia Campello
  • Ludovica Calvo
  • Giuseppina Di Giacomo
  • Vittoria Pagliarini
  • Veronica Bordoni
  • Maria Paola Paronetto
  • James L Manley
  • Jean Luc Perfettini
  • Valentina Iadevaia
  • Antonella Tinari
  • Beatrice Conti
  • Mauro Zaccarelli
  • Carla Cicchini
  • Pamela Bielli
  • Fabio Soldani
  • Laura Amicone
  • Walter Malorni
  • Serafina Oliverio
  • Paolo Visca
  • Gennaro Melino
  • Maria Grazia Farrace
  • Federica Tiburzi
  • Valentina Reali
  • Federica Di Sano
  • Lucia Piredda

Detail Information

Publications17

  1. ncbi Unleashing the Ambra1-Beclin 1 complex from dynein chains: Ulk1 sets Ambra1 free to induce autophagy
    Gian Maria Fimia
    National Institute for Infectious Diseases IRCCS L Spallanzani, Rome, Italy
    Autophagy 7:115-7. 2011
    ..Ambra1 is therefore not only a cofactor of Beclin 1 in favoring its kinase-associated activity, but also a crucial upstream regulator of autophagy initiation...
  2. ncbi Autophagy protects cells from HCV-induced defects in lipid metabolism
    Tiziana Vescovo
    National Institute for Infectious Diseases IRCCS L Spallanzani, Rome, Italy
    Gastroenterology 142:644-653.e3. 2012
    ..High levels of autophagy occur during infection of cells with hepatitis C virus (HCV), but the clinical relevance of this process is not clear...
  3. ncbi ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells
    Alessandra Romagnoli
    Department of Epidemiology and Preclinical Research, National Institute for Infectious Diseases L Spallanzani, Rome, Italy
    Autophagy 8:1357-70. 2012
    ....
  4. ncbi Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
    Flavie Strappazzon
    Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, Rome, Italy
    EMBO J 30:1195-208. 2011
    ..Thus, a dynamic interaction exists between AMBRA1 and BCL-2 at the mitochondria that could regulate both BECLIN 1-dependent autophagy and apoptosis...
  5. ncbi EBV stimulates TLR- and autophagy-dependent pathways and impairs maturation in plasmacytoid dendritic cells: implications for viral immune escape
    Martina Severa
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Eur J Immunol 43:147-58. 2013
    ..These mechanisms might lead to persistence in immunocompetent hosts or to dysregulated immune responses linked to EBV-associated diseases...
  6. ncbi Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages
    Elisa Petruccioli
    Translational Research Unit, University of Rome Tor Vergata, Rome, Italy
    J Infect Dis 205:1425-35. 2012
    ..tuberculosis-mediated autophagy. The aim of this study was to evaluate the impact of M. tuberculosis on autophagy in human primary macrophages and the role of specific T cells in this process...
  7. ncbi Liver protein profiling in chronic hepatitis C: identification of potential predictive markers for interferon therapy outcome
    Ariel Basulto Perdomo
    National Institute for Infectious Diseases IRCCS L Spallanzani, Rome, Italy
    J Proteome Res 11:717-27. 2012
    ....
  8. ncbi Proteomic analysis of mitochondrial dysfunction in neurodegenerative diseases
    Carlo Rodolfo
    Laboratory of Development and Cell Biology, Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Expert Rev Proteomics 7:519-42. 2010
    ..Future developments in this field are expected to significantly contribute to the full comprehension of the molecular mechanisms at the heart of neurodegeneration...
  9. ncbi Proteomic analysis reveals a major role for contact inhibition in the terminal differentiation of hepatocytes
    Carmine Mancone
    Laboratory of Gene Expression, National Institute for Infectious Diseases L Spallanzani IRCCS, Via Portuense 292, Rome, Italy
    J Hepatol 52:234-43. 2010
    ..However, a fine molecular characterization of the relationship between proliferation and differentiation in hepatocytes has been hampered by the lack of reliable in vivo or in vitro models...
  10. ncbi Proteomic analysis identifies prohibitin down-regulation as a crucial event in the mitochondrial damage observed in HIV-infected patients
    Fabiola Ciccosanti
    National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy
    Antivir Ther 15:377-90. 2010
    ..Highly active antiretroviral therapy (HAART) has largely reduced the occurrence of AIDS-related diseases and death in HIV-infected patients. However, HAART produces serious side effects mainly attributed to mitochondrial toxicity...
  11. ncbi The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy
    Simona Pedrotti
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, Rome, Italy
    EMBO J 29:1235-47. 2010
    ..Our results thus indicate that Sam68 is a novel crucial regulator of SMN2 splicing...
  12. ncbi Fenretinide induces autophagic cell death in caspase-defective breast cancer cells
    Barbara Fazi
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Autophagy 4:435-41. 2008
    ..The understanding of the molecular mechanisms involved in fenretinide action is important for the future design of therapies employing this retinoid in breast cancer treatment...
  13. ncbi Dismantling the autophagic arsenal when it is time to die: concerted AMBRA1 degradation by caspases and calpains
    Marco Corazzari
    National Institute for Infectious Disease L Spallanzani IRCCS, Rome, Italy
    Autophagy 8:1255-7. 2012
    ..This phenomenon is not merely a consequence of apoptosis execution but represents a key step required to efficiently promote the autophagic vs apoptosis switch...
  14. ncbi Transglutaminase 2 is involved in autophagosome maturation
    Manuela D'Eletto
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Autophagy 5:1145-54. 2009
    ..These data indicate a role for TG2-mediated post-translational modifications of proteins in the maturation of autophagosomes accompanied by the accumulation of many damaged mitochondria...
  15. ncbi Regulation of autophagy in mammals and its interplay with apoptosis
    Gian Maria Fimia
    National Institute for Infectious Diseases IRCCS Lazzaro Spallanzani, 00149, Rome, Italy
    Cell Mol Life Sci 67:1581-8. 2010
    ..In this mini-review we will focus on some key experiments trying to decipher as to whether autophagy contributes to apoptosis modulation in vivo...
  16. ncbi Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen
    Francesco Imperi
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    Proteomics 9:1901-15. 2009
    ..aeruginosa periplasm and offers the basis for future studies on periplasmic proteome changes occurring during P. aeruginosa adaptation to different environments and/or antibiotic treatments...
  17. ncbi A novel role for autophagy in neurodevelopment
    Francesco Cecconi
    Dulbecco Telethon Institute at the Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Autophagy 3:506-8. 2007
    ..In this article, we review our findings in the contexts of autophagy and neurodevelopment and consider some of the issues raised...