Gian Maria Fimia

Summary

Affiliation: National Institute for Infectious Diseases
Country: Italy

Publications

  1. ncbi request reprint Unleashing the Ambra1-Beclin 1 complex from dynein chains: Ulk1 sets Ambra1 free to induce autophagy
    Gian Maria Fimia
    National Institute for Infectious Diseases IRCCS L Spallanzani, Rome, Italy
    Autophagy 7:115-7. 2011
  2. doi request reprint Autophagy protects cells from HCV-induced defects in lipid metabolism
    Tiziana Vescovo
    National Institute for Infectious Diseases IRCCS L Spallanzani, Rome, Italy
    Gastroenterology 142:644-653.e3. 2012
  3. pmc ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells
    Alessandra Romagnoli
    Department of Epidemiology and Preclinical Research, National Institute for Infectious Diseases L Spallanzani, Rome, Italy
    Autophagy 8:1357-70. 2012
  4. pmc Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
    Flavie Strappazzon
    Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, Rome, Italy
    EMBO J 30:1195-208. 2011
  5. doi request reprint Autophagy in Mycobacterium tuberculosis infection: a passepartout to flush the intruder out?
    Delia Goletti
    Translational Research Unit, Department of Epidemiology and Preclinical Research, INMI, Rome, Italy
    Cytokine Growth Factor Rev 24:335-43. 2013
  6. pmc A new transcriptional repressor of the pseudomonas aeruginosa quorum sensing receptor gene lasR
    Francesca Longo
    Department of Sciences, University Roma Tre, Rome, Italy
    PLoS ONE 8:e69554. 2013
  7. doi request reprint EBV stimulates TLR- and autophagy-dependent pathways and impairs maturation in plasmacytoid dendritic cells: implications for viral immune escape
    Martina Severa
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Eur J Immunol 43:147-58. 2013
  8. doi request reprint Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages
    Elisa Petruccioli
    Translational Research Unit, University of Rome Tor Vergata, Rome, Italy
    J Infect Dis 205:1425-35. 2012
  9. doi request reprint Liver protein profiling in chronic hepatitis C: identification of potential predictive markers for interferon therapy outcome
    Ariel Basulto Perdomo
    National Institute for Infectious Diseases IRCCS L Spallanzani, Rome, Italy
    J Proteome Res 11:717-27. 2012
  10. ncbi request reprint Proteomic analysis of mitochondrial dysfunction in neurodegenerative diseases
    Carlo Rodolfo
    Laboratory of Development and Cell Biology, Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Expert Rev Proteomics 7:519-42. 2010

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Unleashing the Ambra1-Beclin 1 complex from dynein chains: Ulk1 sets Ambra1 free to induce autophagy
    Gian Maria Fimia
    National Institute for Infectious Diseases IRCCS L Spallanzani, Rome, Italy
    Autophagy 7:115-7. 2011
    ..Ambra1 is therefore not only a cofactor of Beclin 1 in favoring its kinase-associated activity, but also a crucial upstream regulator of autophagy initiation...
  2. doi request reprint Autophagy protects cells from HCV-induced defects in lipid metabolism
    Tiziana Vescovo
    National Institute for Infectious Diseases IRCCS L Spallanzani, Rome, Italy
    Gastroenterology 142:644-653.e3. 2012
    ..High levels of autophagy occur during infection of cells with hepatitis C virus (HCV), but the clinical relevance of this process is not clear...
  3. pmc ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells
    Alessandra Romagnoli
    Department of Epidemiology and Preclinical Research, National Institute for Infectious Diseases L Spallanzani, Rome, Italy
    Autophagy 8:1357-70. 2012
    ....
  4. pmc Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
    Flavie Strappazzon
    Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, Rome, Italy
    EMBO J 30:1195-208. 2011
    ..Thus, a dynamic interaction exists between AMBRA1 and BCL-2 at the mitochondria that could regulate both BECLIN 1-dependent autophagy and apoptosis...
  5. doi request reprint Autophagy in Mycobacterium tuberculosis infection: a passepartout to flush the intruder out?
    Delia Goletti
    Translational Research Unit, Department of Epidemiology and Preclinical Research, INMI, Rome, Italy
    Cytokine Growth Factor Rev 24:335-43. 2013
    ..Moreover, we discuss the multiple roles played by autophagy in the immune responses to M. tuberculosis, and its unforeseen contribution to the antibacterial activity of tuberculosis-specific drugs. ..
  6. pmc A new transcriptional repressor of the pseudomonas aeruginosa quorum sensing receptor gene lasR
    Francesca Longo
    Department of Sciences, University Roma Tre, Rome, Italy
    PLoS ONE 8:e69554. 2013
    ..aeruginosa pathogenicity. P. aeruginosa genome encodes at least 38 TetR-family proteins, and PA3699 is the eighth member of this group functionally characterized so far and the first one shown to bind the lasR promoter in vitro. ..
  7. doi request reprint EBV stimulates TLR- and autophagy-dependent pathways and impairs maturation in plasmacytoid dendritic cells: implications for viral immune escape
    Martina Severa
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Eur J Immunol 43:147-58. 2013
    ..These mechanisms might lead to persistence in immunocompetent hosts or to dysregulated immune responses linked to EBV-associated diseases...
  8. doi request reprint Specific T cells restore the autophagic flux inhibited by Mycobacterium tuberculosis in human primary macrophages
    Elisa Petruccioli
    Translational Research Unit, University of Rome Tor Vergata, Rome, Italy
    J Infect Dis 205:1425-35. 2012
    ..tuberculosis-mediated autophagy. The aim of this study was to evaluate the impact of M. tuberculosis on autophagy in human primary macrophages and the role of specific T cells in this process...
  9. doi request reprint Liver protein profiling in chronic hepatitis C: identification of potential predictive markers for interferon therapy outcome
    Ariel Basulto Perdomo
    National Institute for Infectious Diseases IRCCS L Spallanzani, Rome, Italy
    J Proteome Res 11:717-27. 2012
    ....
  10. ncbi request reprint Proteomic analysis of mitochondrial dysfunction in neurodegenerative diseases
    Carlo Rodolfo
    Laboratory of Development and Cell Biology, Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Expert Rev Proteomics 7:519-42. 2010
    ..Future developments in this field are expected to significantly contribute to the full comprehension of the molecular mechanisms at the heart of neurodegeneration...
  11. doi request reprint Proteomic analysis reveals a major role for contact inhibition in the terminal differentiation of hepatocytes
    Carmine Mancone
    Laboratory of Gene Expression, National Institute for Infectious Diseases L Spallanzani IRCCS, Via Portuense 292, Rome, Italy
    J Hepatol 52:234-43. 2010
    ..However, a fine molecular characterization of the relationship between proliferation and differentiation in hepatocytes has been hampered by the lack of reliable in vivo or in vitro models...
  12. ncbi request reprint Fenretinide induces autophagic cell death in caspase-defective breast cancer cells
    Barbara Fazi
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Autophagy 4:435-41. 2008
    ..The understanding of the molecular mechanisms involved in fenretinide action is important for the future design of therapies employing this retinoid in breast cancer treatment...
  13. pmc The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy
    Simona Pedrotti
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, Rome, Italy
    EMBO J 29:1235-47. 2010
    ..Our results thus indicate that Sam68 is a novel crucial regulator of SMN2 splicing...
  14. ncbi request reprint Proteomic analysis identifies prohibitin down-regulation as a crucial event in the mitochondrial damage observed in HIV-infected patients
    Fabiola Ciccosanti
    National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy
    Antivir Ther 15:377-90. 2010
    ..Highly active antiretroviral therapy (HAART) has largely reduced the occurrence of AIDS-related diseases and death in HIV-infected patients. However, HAART produces serious side effects mainly attributed to mitochondrial toxicity...
  15. ncbi request reprint Why is autophagy important for melanoma? Molecular mechanisms and therapeutic implications
    Marco Corazzari
    Department of Biology, University of Rome Tor Vergata, Rome, Italy National Institute for Infectious Diseases IRCCS L Spallanzani, Rome, Italy
    Semin Cancer Biol 23:337-43. 2013
    ..Accordingly, it is now apparent that aberrant control of autophagy is among key hallmarks of cancer, with several studies now demonstrating this process is deregulated also in melanoma...
  16. doi request reprint Dismantling the autophagic arsenal when it is time to die: concerted AMBRA1 degradation by caspases and calpains
    Marco Corazzari
    National Institute for Infectious Disease L Spallanzani IRCCS, Rome, Italy
    Autophagy 8:1255-7. 2012
    ..This phenomenon is not merely a consequence of apoptosis execution but represents a key step required to efficiently promote the autophagic vs apoptosis switch...
  17. ncbi request reprint Transglutaminase 2 is involved in autophagosome maturation
    Manuela D'Eletto
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Autophagy 5:1145-54. 2009
    ..These data indicate a role for TG2-mediated post-translational modifications of proteins in the maturation of autophagosomes accompanied by the accumulation of many damaged mitochondria...
  18. doi request reprint Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen
    Francesco Imperi
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    Proteomics 9:1901-15. 2009
    ..aeruginosa periplasm and offers the basis for future studies on periplasmic proteome changes occurring during P. aeruginosa adaptation to different environments and/or antibiotic treatments...
  19. doi request reprint Regulation of autophagy in mammals and its interplay with apoptosis
    Gian Maria Fimia
    National Institute for Infectious Diseases IRCCS Lazzaro Spallanzani, 00149, Rome, Italy
    Cell Mol Life Sci 67:1581-8. 2010
    ..In this mini-review we will focus on some key experiments trying to decipher as to whether autophagy contributes to apoptosis modulation in vivo...
  20. ncbi request reprint A novel role for autophagy in neurodevelopment
    Francesco Cecconi
    Dulbecco Telethon Institute at the Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Autophagy 3:506-8. 2007
    ..In this article, we review our findings in the contexts of autophagy and neurodevelopment and consider some of the issues raised...