G Cutrona

Summary

Affiliation: National Cancer Research Institute
Country: Italy

Publications

  1. ncbi The peptide nucleic acid targeted to a regulatory sequence of the translocated c-myc oncogene in Burkitt's lymphoma lacks immunogenicity: follow-up characterization of PNAEmu-NLS
    Giovanna Cutrona
    SC Oncologia Medica C, Istituto Nazionale per la Ricerca sul Cancro, IST, Genova, Italy
    Oligonucleotides 17:146-50. 2007
  2. ncbi B lymphocytes in humans express ZAP-70 when activated in vivo
    Giovanna Cutrona
    Division of Medical Oncology C, Istituto Nazionale per la Ricerca sul Cancro, IST, Genova, Italy
    Eur J Immunol 36:558-69. 2006
  3. ncbi Inhibition of the translocated c-myc in Burkitt's lymphoma by a PNA complementary to the E mu enhancer
    Giovanna Cutrona
    Division of Medical Oncology C, National Cancer Research Institute, Istituto Superiore di Sanita, Largo R Benzi 10, 16132 Genoa, Italy
    Cancer Res 63:6144-8. 2003
  4. doi Clonal heterogeneity in chronic lymphocytic leukemia cells: superior response to surface IgM cross-linking in CD38, ZAP-70-positive cells
    Giovanna Cutrona
    PhD Divisione di Oncologia Medica C Istituto Nazionale per la Ricerca sul Cancro, IST, L go Rosanna Benzi, 10 16132 Genoa, Italy
    Haematologica 93:413-22. 2008
  5. pmc CD10 is a marker for cycling cells with propensity to apoptosis in childhood ALL
    G Cutrona
    Servizi di Immunologia Clinica, Istituto Nazionale per la Ricerca sul Cancro, IST, Genoa, Italy, and Dipartimento di Oncologia, Biologia e Genetica, Universita di Genova, Genoa, Italy
    Br J Cancer 86:1776-85. 2002
  6. doi PNAEmu can significantly reduce Burkitt's lymphoma tumor burden in a SCID mice model: cells dissemination similar to the human disease
    S Matis
    S C Oncologia Medica C, Istituto Nazionale per la Ricerca sul Cancro, IST, 16132 Genova, Italy
    Cancer Gene Ther 16:786-93. 2009
  7. ncbi Analysis of stepwise genetic changes in an AIDS-related Burkitt's lymphoma
    F Fais
    Clinical Immunology Division, National Cancer Institute, Genoa, Italy
    Int J Cancer 88:744-50. 2000
  8. ncbi Lack of mutagenicity and clastogenicity of PNAEmu-NLS targeted to a regulatory sequence of the translocated c-myc oncogene in Burkitt's lymphoma
    L C Boffa
    Medical Oncology C, National Cancer Research Institute, IST, corrected L go R Benzi 10, 16132 Genova, Italy
    Mutat Res 628:129-37. 2007
  9. ncbi Identification of HSP-60 as the specific antigen of IgM produced by BRG-lymphoma cells
    L Musante
    Department of Nephrology, Giannina Gaslini Children Hospital, Genova, Italy
    Electrophoresis 20:1092-7. 1999
  10. ncbi Expression of CD10 by human T cells that undergo apoptosis both in vitro and in vivo
    G Cutrona
    Servizio di Immunologia Clinica and Servizio di Citometria CBA, Istituto Nazionale per la Ricerca sul Cancro, IST Genoa, Italy
    Blood 94:3067-76. 1999

Collaborators

Detail Information

Publications23

  1. ncbi The peptide nucleic acid targeted to a regulatory sequence of the translocated c-myc oncogene in Burkitt's lymphoma lacks immunogenicity: follow-up characterization of PNAEmu-NLS
    Giovanna Cutrona
    SC Oncologia Medica C, Istituto Nazionale per la Ricerca sul Cancro, IST, Genova, Italy
    Oligonucleotides 17:146-50. 2007
    ..Antibodies to free PNA were undetected, whereas both IgG and IgM antibodies to PNA-KLH were detected in mouse serum 28 and 38 days after inoculation...
  2. ncbi B lymphocytes in humans express ZAP-70 when activated in vivo
    Giovanna Cutrona
    Division of Medical Oncology C, Istituto Nazionale per la Ricerca sul Cancro, IST, Genova, Italy
    Eur J Immunol 36:558-69. 2006
    ..B-CLL cells are activated cells and their ZAP-70 expression reflects a normal property of activated B cells populations rather than a neoplastic aberration...
  3. ncbi Inhibition of the translocated c-myc in Burkitt's lymphoma by a PNA complementary to the E mu enhancer
    Giovanna Cutrona
    Division of Medical Oncology C, National Cancer Research Institute, Istituto Superiore di Sanita, Largo R Benzi 10, 16132 Genoa, Italy
    Cancer Res 63:6144-8. 2003
    ..This Peptide Nucleic Acid also inhibited IgM expression in B cells. The finding that PNAs specific for a regulatory noncoding sequence can block gene expression has important conceptual and practical implications...
  4. doi Clonal heterogeneity in chronic lymphocytic leukemia cells: superior response to surface IgM cross-linking in CD38, ZAP-70-positive cells
    Giovanna Cutrona
    PhD Divisione di Oncologia Medica C Istituto Nazionale per la Ricerca sul Cancro, IST, L go Rosanna Benzi, 10 16132 Genoa, Italy
    Haematologica 93:413-22. 2008
    ..We studied whether cells expressing CD38 and ZAP-70 are more susceptible to stimulation through B-cell receptors than are cells that do not express CD38 and ZAP-70...
  5. pmc CD10 is a marker for cycling cells with propensity to apoptosis in childhood ALL
    G Cutrona
    Servizi di Immunologia Clinica, Istituto Nazionale per la Ricerca sul Cancro, IST, Genoa, Italy, and Dipartimento di Oncologia, Biologia e Genetica, Universita di Genova, Genoa, Italy
    Br J Cancer 86:1776-85. 2002
    ....
  6. doi PNAEmu can significantly reduce Burkitt's lymphoma tumor burden in a SCID mice model: cells dissemination similar to the human disease
    S Matis
    S C Oncologia Medica C, Istituto Nazionale per la Ricerca sul Cancro, IST, 16132 Genova, Italy
    Cancer Gene Ther 16:786-93. 2009
    ..Altogether, the data support the therapeutic potential of PNAEmu in human adult BL...
  7. ncbi Analysis of stepwise genetic changes in an AIDS-related Burkitt's lymphoma
    F Fais
    Clinical Immunology Division, National Cancer Institute, Genoa, Italy
    Int J Cancer 88:744-50. 2000
    ..These events occurred prior to or during the germinal center (GC) phase of B-cell maturation. Thereafter, possibly upon exit of the cells from the GC, EBV infection occurred, further promoting lymphomagenesis...
  8. ncbi Lack of mutagenicity and clastogenicity of PNAEmu-NLS targeted to a regulatory sequence of the translocated c-myc oncogene in Burkitt's lymphoma
    L C Boffa
    Medical Oncology C, National Cancer Research Institute, IST, corrected L go R Benzi 10, 16132 Genova, Italy
    Mutat Res 628:129-37. 2007
    ..We may conclude that PNAEmu-NLS neither induces mutations nor has clastogenic effects as detectable by treatment under the standard test conditions...
  9. ncbi Identification of HSP-60 as the specific antigen of IgM produced by BRG-lymphoma cells
    L Musante
    Department of Nephrology, Giannina Gaslini Children Hospital, Genova, Italy
    Electrophoresis 20:1092-7. 1999
    ..It is hypothesized that this molecule is a membrane form of HSP-60 that differs from HSP-60 in a COOH terminal portion...
  10. ncbi Expression of CD10 by human T cells that undergo apoptosis both in vitro and in vivo
    G Cutrona
    Servizio di Immunologia Clinica and Servizio di Citometria CBA, Istituto Nazionale per la Ricerca sul Cancro, IST Genoa, Italy
    Blood 94:3067-76. 1999
    ....
  11. ncbi Inhibition of Burkitt's lymphoma cells growth in SCID mice by a PNA specific for a regulatory sequence of the translocated c-myc
    L C Boffa
    SC Oncologia Medica C, Istituto Nazionale per la Ricerca sul Cancro, IST, Largo R Benzi, GE 10 Genoa 16132, Italy
    Cancer Gene Ther 14:220-6. 2007
    ..These data confirm the potential therapeutic value of PNA targeted to regulatory non-coding regions...
  12. ncbi Apoptosis induced by crosslinking of CD4 on activated human B cells
    G Cutrona
    Istituto Nazionale per la Ricerca sul Cancro, IST Servizio di Immunologia Clinica, Genoa, 16132, Italy
    Cell Immunol 193:80-9. 1999
    ..Exposure of CD4 expressing B cells to gp120 under conditions that resulted in CD4 crosslinking also caused apoptosis suggesting some implications for the pathophysiology of AIDS...
  13. ncbi Therapeutically promising PNA complementary to a regulatory sequence for c-myc: pharmacokinetics in an animal model of human Burkitt's lymphoma
    Lidia C Boffa
    SS Epigenetics, Istituto Nazionale per la Ricerca sul Cancro, IST, Genova, Italy
    Oligonucleotides 15:85-93. 2005
    ....
  14. ncbi CD5+ B cells with the features of subepithelial B cells found in human tonsils
    Mariella Dono
    S C Oncologia Medica C, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Eur J Immunol 37:2138-47. 2007
    ..These data are discussed considering the present views on the origin of B cell subset populations and the relationships between MZ and B1 cells...
  15. ncbi The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways
    Daniela de Totero
    Department of Translational Oncology and Medical Oncology C, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Blood 111:517-24. 2008
    ..The knowledge of the signaling pathways regulating CLL cell survival and proliferation may provide new molecular targets for therapeutic intervention...
  16. doi Heterogeneous expression and function of IL-21R and susceptibility to IL-21-mediated apoptosis in follicular lymphoma cells
    Daniela de Totero
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Exp Hematol 38:373-83. 2010
    ..IL-21 may either induce apoptosis or promote growth in different lymphoid malignancies. We therefore investigated the IL-21/IL-21R system in follicular lymphoma (FL) cells...
  17. doi Constitutive expression of IL-12R beta 2 on human multiple myeloma cells delineates a novel therapeutic target
    Irma Airoldi
    Department of Experimental and Laboratory Medicine, G Gaslini Institute, Genova, Italy
    Blood 112:750-9. 2008
    ..Thus, IL-12R beta 2 directly restrains MM cell growth, and targeting of IL-12 to tumor cells holds promise as new therapeutic strategy...
  18. ncbi Role of surface IgM and IgD on survival of the cells from B-cell chronic lymphocytic leukemia
    Simona Zupo
    Blood 99:2277-8. 2002
  19. ncbi Expression of CD10 by B-chronic lymphocytic leukemia cells undergoing apoptosis in vivo and in vitro
    Fortunato Morabito
    Dipartimento di Ematologia Azienda, Ospedaliera Bianchi Melacrino, Reggio Calabria, Italy
    Haematologica 88:864-73. 2003
    ..The aim of this study was to ascertain whether B-CLL cells, induced into apoptosis, expressed surface CD10, since a correlation between apoptosis and CD10 expression has been demonstrated...
  20. doi Molecular and transcriptional characterization of 17p loss in B-cell chronic lymphocytic leukemia
    Sonia Fabris
    Centro per lo Studio delle Leucemie, Dipartimento di Scienze Mediche, Universita di Milano, U O Ematologia 1, Fondazione IRCCS Policlinico, Milano, Italy
    Genes Chromosomes Cancer 47:781-93. 2008
    ....
  21. doi Serum thrombopoietin compared with ZAP-70 and immunoglobulin heavy-chain gene mutation status as a predictor of time to first treatment in early chronic lymphocytic leukemia
    Stefano Molica
    Department of Oncology Hematology, Azienda Ospedaliera Pugliese Ciaccio, Catanzaro, Italy
    Leuk Lymphoma 49:62-7. 2008
    ..In conclusion, our results indicate that in early B-cell CLL circulating level of TPO does not provide a useful insight into the complex interrelationship of prognostic variables...
  22. pmc In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells
    Bradley T Messmer
    Institute for Medical Research, North Shore LIJ Research Institute, Manhasset, New York 11030, USA
    J Clin Invest 115:755-64. 2005
    ..A correlation between birth rates and disease activity and progression appears to exist, which may help identify patients at risk for worsening disease in advance of clinical deterioration...
  23. ncbi Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells
    Daniela de Totero
    Laboratory of Immunotherapy, IST c o CBA Largo R Benzi, 10, 16132 Genova, Italy
    Blood 107:3708-15. 2006
    ..The present findings thus provide a set of new mechanisms involved in the balance between cell-survival and apoptotic signals in CLL B cells...