Maria R Capobianchi

Summary

Affiliation: National Institute for Infectious Diseases
Country: Italy

Publications

  1. pmc Retrospective investigation of an influenza A/H1N1pdm outbreak in an Italian military ship cruising in the Mediterranean Sea, May-September 2009
    Mario Tarabbo
    Inspectorate of Health, ITA Navy, Rome, Italy
    PLoS ONE 6:e15933. 2011
  2. pmc Hepatitis E virus genotype 4 outbreak, Italy, 2011
    Anna R Garbuglia
    Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy
    Emerg Infect Dis 19:110-4. 2013
  3. pmc IFN-Alpha Receptor-1 Upregulation in PBMC from HCV Naïve Patients Carrying CC Genotype. Possible Role of IFN-Lambda
    Eleonora Lalle
    Laboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    PLoS ONE 9:e93434. 2014
  4. ncbi request reprint Molecular characterization of hepatitis A outbreak in the province of Rome, Lazio region, Italy, January-July 2013
    Maria R Capobianchi
    Laboratory of Virology, National Institute for Infectious Diseases L Spallanzani, Via Portuense 292, 00149 Rome, Italy Electronic address
    Microbes Infect 16:362-6. 2014
  5. doi request reprint Next-generation sequencing technology in clinical virology
    M R Capobianchi
    National Institute for Infectious Diseases L Spallanzani, Rome, Italy
    Clin Microbiol Infect 19:15-22. 2013
  6. ncbi request reprint Extent of HCV NS3 protease variability and resistance-associated mutations assessed by next generation sequencing in HCV monoinfected and HIV/HCV coinfected patients
    Barbara Bartolini
    L Spallanzani National institute for infectious diseases, Via Portuense 292, 00149 Rome, Italy
    Virus Res 177:205-8. 2013
  7. pmc Massively parallel pyrosequencing highlights minority variants in the HIV-1 env quasispecies deriving from lymphomonocyte sub-populations
    Gabriella Rozera
    Laboratory of Virology, INMI L, Spallanzani, Rome, Italy
    Retrovirology 6:15. 2009
  8. ncbi request reprint Possible compartmentalization of hepatitis C viral replication in the genital tract of HIV-1-coinfected women
    Claudia Minosse
    Laboratory of Virology, National Institute of Infectious Diseases L Spallanzani, 292 00149 Rome, Italy
    J Infect Dis 194:1529-36. 2006
  9. ncbi request reprint The effect of age on response to therapy with peginterferon alpha plus ribavirin in a cohort of patients with chronic HCV hepatitis including subjects older than 65 yr
    Giorgio Antonucci
    Clinical Department of Infectious Disease, National Institute for Infectious Disease, L Spallanzani, Rome, Italy
    Am J Gastroenterol 102:1383-91. 2007
  10. doi request reprint Ultra-deep sequencing reveals hidden HIV-1 minority lineages and shifts of viral population between the main cellular reservoirs of the infection after therapy interruption
    Gabriella Rozera
    National Institute for Infectious Diseases L Spallanzani, Rome, Italy
    J Med Virol 84:839-44. 2012

Detail Information

Publications47

  1. pmc Retrospective investigation of an influenza A/H1N1pdm outbreak in an Italian military ship cruising in the Mediterranean Sea, May-September 2009
    Mario Tarabbo
    Inspectorate of Health, ITA Navy, Rome, Italy
    PLoS ONE 6:e15933. 2011
    ..Here we report a serological investigation on an influenza A/H1N1pdm outbreak in an Italian military ship while cruising in the Mediterranean Sea (May 24-September 6, 2009)...
  2. pmc Hepatitis E virus genotype 4 outbreak, Italy, 2011
    Anna R Garbuglia
    Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy
    Emerg Infect Dis 19:110-4. 2013
    ..Detection of this genotype in Italy parallels findings in other countries in Europe, signaling the possible spread of strains new to Western countries...
  3. pmc IFN-Alpha Receptor-1 Upregulation in PBMC from HCV Naïve Patients Carrying CC Genotype. Possible Role of IFN-Lambda
    Eleonora Lalle
    Laboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    PLoS ONE 9:e93434. 2014
    ..The study aim was to establish possible relationships between IL-28B rs12979860 genotypes and expression of IFN-alpha receptor-1 (IFNAR-1) in naïve HCV patients, and to explore the possible role of IFN-lambda...
  4. ncbi request reprint Molecular characterization of hepatitis A outbreak in the province of Rome, Lazio region, Italy, January-July 2013
    Maria R Capobianchi
    Laboratory of Virology, National Institute for Infectious Diseases L Spallanzani, Via Portuense 292, 00149 Rome, Italy Electronic address
    Microbes Infect 16:362-6. 2014
    ..This strain is also very similar to previous isolates from Venezuela. ..
  5. doi request reprint Next-generation sequencing technology in clinical virology
    M R Capobianchi
    National Institute for Infectious Diseases L Spallanzani, Rome, Italy
    Clin Microbiol Infect 19:15-22. 2013
    ..The diagnostic application of NGS is just around the corner...
  6. ncbi request reprint Extent of HCV NS3 protease variability and resistance-associated mutations assessed by next generation sequencing in HCV monoinfected and HIV/HCV coinfected patients
    Barbara Bartolini
    L Spallanzani National institute for infectious diseases, Via Portuense 292, 00149 Rome, Italy
    Virus Res 177:205-8. 2013
    ....
  7. pmc Massively parallel pyrosequencing highlights minority variants in the HIV-1 env quasispecies deriving from lymphomonocyte sub-populations
    Gabriella Rozera
    Laboratory of Virology, INMI L, Spallanzani, Rome, Italy
    Retrovirology 6:15. 2009
    ..V3 amino acid sequences were used to establish heterogeneity parameters, to build phylogenetic trees and to predict co-receptor usage...
  8. ncbi request reprint Possible compartmentalization of hepatitis C viral replication in the genital tract of HIV-1-coinfected women
    Claudia Minosse
    Laboratory of Virology, National Institute of Infectious Diseases L Spallanzani, 292 00149 Rome, Italy
    J Infect Dis 194:1529-36. 2006
    ..Possible compartmentalization of viral quasi species in the genital tract and plasma was evaluated by comparison of genetic heterogeneity and use of phylogenetic analysis...
  9. ncbi request reprint The effect of age on response to therapy with peginterferon alpha plus ribavirin in a cohort of patients with chronic HCV hepatitis including subjects older than 65 yr
    Giorgio Antonucci
    Clinical Department of Infectious Disease, National Institute for Infectious Disease, L Spallanzani, Rome, Italy
    Am J Gastroenterol 102:1383-91. 2007
    ..This study was set up to evaluate the effect of age on the treatment of chronic HCV hepatitis with peginterferon alpha plus ribavirin...
  10. doi request reprint Ultra-deep sequencing reveals hidden HIV-1 minority lineages and shifts of viral population between the main cellular reservoirs of the infection after therapy interruption
    Gabriella Rozera
    National Institute for Infectious Diseases L Spallanzani, Rome, Italy
    J Med Virol 84:839-44. 2012
    ..A spread of proviral X4 lineages hidden in monocytes to T cells was observed, but this was not associated with an overall shift towards CXCR4 using variants during the observation period...
  11. pmc Duration of viral shedding in hospitalized patients infected with pandemic H1N1
    Silvia Meschi
    Laboratory of Virology, National Institute for Infectious Diseases L, Spallanzani, 292 Via Portuense, Rome, Italy
    BMC Infect Dis 11:140. 2011
    ..This study was aimed at investigating the influence of clinical presentation, antiviral treatment and possible drug resistance-associated mutations, on the extent and duration of viral shedding in patients infected with A/H1N1pdm...
  12. ncbi request reprint Improved detection of human influenza A and B viruses in respiratory tract specimens by hemi-nested PCR
    Claudia Minosse
    Laboratory of Virology, National Institute of Infectious Diseases L Spallanzani, Rome, Italy
    J Virol Methods 141:225-8. 2007
    ..4% and 5.8% positivity for influenza A and B, respectively. The results were confirmed by sequence analysis: apart from influenza B, both influenza A subtypes H3N2 and H1N1, associated with the seasonal outbreak, were detected...
  13. pmc Comparison of LCx with other current viral load assays for detecting and quantifying human immunodeficiency virus type 1 RNA in patients infected with the circulating recombinant form A/G (CRF02)
    Alessandra Amendola
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    J Clin Microbiol 42:811-5. 2004
    ..LCx showed significant but low correlation with the other methods. Values of <2.60 log(10) cp/ml were observed in 29.6% of specimens with LCx and in only 14.8% with bDNA and PCR, suggesting suboptimal performance of LCx with CRF02...
  14. doi request reprint Detection of quasispecies variants predicted to use CXCR4 by ultra-deep pyrosequencing during early HIV infection
    Isabella Abbate
    Laboratory of Virology, Clinical Department, National Institute of Infectious Diseases INMI, Lazzaro Spallanzani, Italy
    AIDS 25:611-7. 2011
    ....
  15. ncbi request reprint Indomethacin has a potent antiviral activity against SARS coronavirus
    Carla Amici
    Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Antivir Ther 11:1021-30. 2006
    ..Existing in non-identified animal reservoirs, SARS-CoV continues to represent a threat to humans because there is no effective specific antiviral therapy for coronavirus infections...
  16. doi request reprint Use of massive parallel pyrosequencing for near full-length characterization of a unique HIV Type 1 BF recombinant associated with a fatal primary infection
    Alessandro Bruselles
    INMI L Spallanzani, Rome, Italy
    AIDS Res Hum Retroviruses 25:937-42. 2009
    ..Our data provide evidence that next generation sequencing may provide a major contribution to HIV-1 molecular epidemiology and to the comprehension of intrapatient heterogeneity...
  17. pmc Cellular and humoral immune responses to pandemic influenza vaccine in healthy and in highly active antiretroviral therapy-treated HIV patients
    Chiara Agrati
    National Institute for Infectious Diseases INMI Lazzaro Spallanzani, Rome, Italy
    AIDS Res Hum Retroviruses 28:1606-16. 2012
    ..These data show the effectiveness of adjuvanted pandemic vaccine to induce both humoral and cellular (strain-specific and cross-reactive) immune responses in HIV patients similar to HCWs...
  18. doi request reprint In vivo interferon-alpha/ribavirin treatment modulates Vγ9Vδ2 T-cell function during chronic HCV infection
    Eleonora Cimini
    Cellular Immunology Laboratory, INMI L Spallanzani, Rome, Italy
    J Interferon Cytokine Res 33:136-41. 2013
    ....
  19. ncbi request reprint Temporal trend and characteristics of recent HIV-1 infections: application of an algorithm for the identification of recently acquired HIV-1 infections among newly diagnosed individuals over a 10-year period
    Nicoletta Orchi
    Department of Epidemiology Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy
    New Microbiol 36:353-61. 2013
    ..49, [CI 0.37-0.66]). By the application of our algorithm we could characterize the pattern of ongoing HIV transmission, identifying groups needing more urgent prevention programs...
  20. doi request reprint Interferon may prevent HIV viral rebound after HAART interruption in HIV patients
    Ferdinando Dianzani
    National Institute for Infectious Diseases L Spallanzani, Rome, Italy
    J Interferon Cytokine Res 28:1-3. 2008
    ....
  21. pmc Cowpox virus in llama, Italy
    Giusy Cardeti
    Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana, Rome, Italy
    Emerg Infect Dis 17:1513-5. 2011
    ..CPXV-antibodies were detected in llama and human serum samples; a CPXV isolate had a hemagglutinin sequence identical to CPXV-MonKre08/1-2-3 strains isolated from banded mongooses in Germany...
  22. ncbi request reprint Differential expression of Werner and Bloom syndrome genes in the peripheral blood of HIV-1 infected patients
    Licia Bordi
    Laboratory of Virology, National Institute for Infectious Diseases, Rome, Italy
    Hum Immunol 68:91-9. 2007
    ....
  23. ncbi request reprint Rapid detection and quantification of Chikungunya virus by a one-step reverse transcription polymerase chain reaction real-time assay
    Fabrizio Carletti
    National Institute for Infectious Diseases L Spallanzani, Rome, Italy
    Am J Trop Med Hyg 77:521-4. 2007
    ..This new real-time RT-PCR was used to measure viral load in serum samples from cases recently imported to Italy, and may be a useful tool in rapid detection of CHIKV and monitoring the extent of viral replication in patients...
  24. doi request reprint Structural dynamics of V3 loop with different electrostatics: implications on co-receptor recognition: a molecular dynamics study of HIV gp120
    Balasubramanian Chandramouli
    Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome, Italy
    J Biomol Struct Dyn 31:403-13. 2013
    ....
  25. doi request reprint Effect of raltegravir on the total and unintegrated proviral HIV DNA during raltegravir-based HAART
    Emanuele Nicastri
    National Institute for Infectious Diseases, IRCCS Lazzaro Spallanzani, Rome, Italy
    Antivir Ther 16:797-803. 2011
    ..The aim of the study is to test if raltegravir plasma concentrations can be associated with proviral DNA decline during raltegravir-based salvage therapy...
  26. ncbi request reprint Alkhurma hemorrhagic Fever in travelers returning from egypt, 2010
    Fabrizio Carletti
    Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy
    Emerg Infect Dis 17:1574. 2011
    ..Indeed, its subsequent discovery in southern China (3) suggested that migratory birds might carry the infected ticks to or from that region...
  27. ncbi request reprint Rapid, differential diagnosis of orthopox- and herpesviruses based upon real-time PCR product melting temperature and restriction enzyme analysis of amplicons
    Fabrizio Carletti
    Laboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Via Portuense, 292, 00149 Rome, Italy
    J Virol Methods 129:97-100. 2005
    ..Further identification of individual pathogens was made using restriction enzyme analysis. The assay was able to identify correctly viruses from quality control panels of herpes and orthopoxviruses...
  28. ncbi request reprint Genetic variability in E6, E7 and L1 protein of HPV81 from HIV-1 positive women in Italy
    Claudia Minosse
    Laboratory of Virology, L Spallanzani National institute for infectious diseases, Rome, Italy
    New Microbiol 33:25-35. 2010
    ..The importance of polymorphisms on HPV81 persistence and pathogenicity needs to be addressed in longitudinal studies involving larger patient numbers...
  29. ncbi request reprint Cell membrane proteins and quasispecies compartmentalization of CSF and plasma HIV-1 from aids patients with neurological disorders
    Isabella Abbate
    National Institute for Infectious Diseases L Spallanzani IRCCS, Laboratory of Virology, Via Portuense, 292 00149 Rome, Italy Sandro Pertini Hospital, Rome, Italy
    Infect Genet Evol 5:247-53. 2005
    ....
  30. pmc Cross-subtype immunity against avian influenza in persons recently vaccinated for influenza
    Cristiana Gioia
    Laboratory of Virology, National Institute for Infectious Diseases Lazzaro Spallanzani, Istituti di Ricovero e Cura a Carattere Scientifico, Via Portuense 292, Rome, Italy
    Emerg Infect Dis 14:121-8. 2008
    ..These findings highlight the possibility of boosting cross-type cellular and humoral immunity against highly pathogenic avian influenza A virus subtype H5N1 by seasonal influenza vaccination...
  31. ncbi request reprint Assembly and characterization of pandemic influenza A H1N1 genome in nasopharyngeal swabs using high-throughput pyrosequencing
    Barbara Bartolini
    National Institute for Infectious Diseases, L Spallanzani, Rome, Italy
    New Microbiol 34:391-7. 2011
    ..This approach could be of great value in identifying possibly new reassortants that may occur in the near future...
  32. ncbi request reprint Coordinate induction of IFN-alpha and -gamma by SARS-CoV also in the absence of virus replication
    Concetta Castilletti
    Laboratory of Virology, National Institute for Infectious Diseases INMI, L Spallanzani, Via Portuense, 292, 00149 Rome, Italy
    Virology 341:163-9. 2005
    ..This study is aimed at investigating the capability of SARS-CoV to activate IFN-alpha and -gamma expression in lymphomonocytes (PBMC) from healthy donors, evaluating whether viral replication is necessary for this activation...
  33. pmc Alkhurma hemorrhagic fever in travelers returning from Egypt, 2010
    Fabrizio Carletti
    Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy
    Emerg Infect Dis 16:1979-82. 2010
    ..Two travelers returning to Italy from southern Egypt were hospitalized with a fever of unknown origin. Test results showed infection with Alkhurma virus. The geographic distribution of this virus could be broader than previously thought...
  34. ncbi request reprint HVR-1 quasispecies modifications occur early and are correlated to initial but not sustained response in HCV-infected patients treated with pegylated- or standard-interferon and ribavirin
    Isabella Abbate
    Department of Virology, National Institute for Infectious Diseases L Spallanzani, Rome, Italy
    J Hepatol 40:831-6. 2004
    ..HVR-1 quasispecies composition and evolution were investigated in patients chronically infected with genotype 1b HCV, treated with PEG-IFN alpha 2b or STD-IFN alpha 2b plus RBV...
  35. pmc Application of a molecular panel to demonstrate enterotropic virus shedding by healthy and human immunodeficiency virus-infected patients
    Claudia Minosse
    Laboratory of Virology, National Institute for Infectious Diseases INMI L Spallanzani, Via Portuense, 292 00149 Rome, Italy
    J Clin Microbiol 43:1979-81. 2005
    ..This approach favors rapidity and sensitivity of laboratory diagnosis of viral enteric syndromes...
  36. ncbi request reprint Importance of V3 Loop Flexibility and Net Charge in the Context of Co-Receptor Recognition. A Molecular Dynamics Study on HIV gp120
    Chandramouli Balasubramanian
    a Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, Rome, 00133, Italy
    J Biomol Struct Dyn 29:1-13. 2012
    ....
  37. ncbi request reprint Slow response to entecavir treatment in treatment-naive HBV patients is conditioned by immune response rather than by the presence or selection of refractory variants
    Mariacarmela Solmone
    National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Laboratory of Virology, Rome, Italy
    Antivir Ther 19:201-9. 2014
    ..One of the main concerns is the long time to viral suppression observed in some (even treatment-naive) patients. The reasons for this phenomenon were investigated in a group of chronic hepatitis B treatment-naive patients...
  38. pmc Molecular epidemiology of a hepatitis C virus epidemic in a haemodialysis unit: outbreak investigation and infection outcome
    Simone Lanini
    Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani via Portuense 292 00149 Rome, Italy
    BMC Infect Dis 10:257. 2010
    ..The present report is to identify the pathway of HCV transmission during an outbreak of HCV infection in a privately run haemodialysis (HD) unit in Italy in 2005...
  39. pmc A molecular beacon, bead-based assay for the detection of nucleic acids by flow cytometry
    Douglas Horejsh
    National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS Rome, Italy
    Nucleic Acids Res 33:e13. 2005
    ..Considering that routine flow cytometers are able to detect up to four fluorescent channels, this novel assay may allow for the specific multiplex detection of a nucleic acid panel in a single tube...
  40. ncbi request reprint Sepharose-bound, highly sulfated glycosaminoglycans can capture HIV-1 from culture medium
    Barbara Curatella
    Istituto di Cristallografia, Sezione di Monterotondo, CNR, PO Box 10, I 00016 Monterotondo Stazione, Rome, Italy
    Carbohydr Res 340:759-64. 2005
    ..The resins bind the virus very tightly and could be useful for capturing the virus from infected fluids...
  41. pmc Ability of two commercially available assays (Abbott RealTime HIV-1 and Roche Cobas AmpliPrep/Cobas TaqMan HIV-1 Version 2.0) to quantify low HIV-1 RNA Levels (<1,000 copies/milliliter): comparison with clinical samples and NIBSC working reagent for nu
    Alessandra Amendola
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    J Clin Microbiol 52:2019-26. 2014
    ..are defined and indicated in the support of clinical decisions. ..
  42. ncbi request reprint Underevaluation of HIV-1 plasma viral load by a commercially available assay in a cluster of patients infected with HIV-1 A/G circulating recombinant form (CRF02)
    Alessandra Amendola
    Laboratory of Virology, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Via Portuense 292, 00149 Rome, Italy
    J Acquir Immune Defic Syndr 31:488-94. 2002
    ..These results are potentially important as global distribution of new HIV-1 subtypes is expanding, and recombinant strains, particularly CRF02, are emerging and becoming highly prevalent...
  43. ncbi request reprint Monophyletic HIV type 1 CRF02-AG in a nosocomial outbreak in Benghazi, Libya
    Ubaldo Visco-Comandini
    National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy
    AIDS Res Hum Retroviruses 18:727-32. 2002
    ..The data thus suggest a highly contagious nosocomial spread of HIV-1 infection and possibly transmission of the virus from child to mother during breastfeeding in connection with primary HIV-1 infection...
  44. pmc Transmission of hemagglutinin D222G mutant strain of pandemic (H1N1) 2009 virus
    Simona Puzelli
    National Institute of Health, Rome, Italy
    Emerg Infect Dis 16:863-5. 2010
    ..Only mild illness developed in the contact, despite his obesity and diabetes. The isolated virus reacted fully with an antiserum against the pandemic vaccine strain...
  45. pmc Simple and reliable method for detection and genotyping of hepatitis C virus RNA in dried blood spots stored at room temperature
    Mariacarmela Solmone
    National Institute for Infectious Diseases L Spallanzani, IRCCS, Rome, Italy
    J Clin Microbiol 40:3512-4. 2002
    ....
  46. ncbi request reprint Accuracy of malaria diagnosis by microscopy, rapid diagnostic test, and PCR methods and evidence of antimalarial overprescription in non-severe febrile patients in two Tanzanian hospitals
    Emanuele Nicastri
    Virology Laboratory, Epidemiology Department, National Institute for Infectious Diseases Lazzaro Spallanzani INMI, Via Portuense 292, 00149 Rome, Italy
    Am J Trop Med Hyg 80:712-7. 2009
    ..5% and 97.6%, respectively. Overprescription and underdiagnosis rates were 29.3% and 30.8%, respectively. On-field training, clinical management of febrile illness, and malaria microscopy in remote settings should be considered...
  47. doi request reprint Multicenter comparative study of Epstein-Barr virus DNA quantification for virological monitoring in transplanted patients
    Isabella Abbate
    Laboratory of Virology, INMI L Spallanzani, Rome, Italy
    J Clin Virol 50:224-9. 2011
    ..However, the definition of clinically relevant cut-off values is hampered by the lack of standardization in EBV DNA testing...