S Bonassi

Summary

Affiliation: National Cancer Research Institute
Country: Italy

Publications

  1. ncbi request reprint Biomarkers in molecular epidemiology studies for health risk prediction
    Stefano Bonassi
    Department of Environmental Epidemiology, National Cancer Research Institute, Genoa, Italy
    Mutat Res 511:73-86. 2002
  2. ncbi request reprint Children's exposure to environmental pollutants and biomarkers of genetic damage. II. Results of a comprehensive literature search and meta-analysis
    Monica Neri
    Unit of Epidemiology and Biostatistics, Department of Epidemiology and Prevention, National Cancer Research Institute, Largo Rosanna Benzi, 10, 16132 Genoa, Italy
    Mutat Res 612:14-39. 2006
  3. pmc Association between frequency of chromosomal aberrations and cancer risk is not influenced by genetic polymorphisms in GSTM1 and GSTT1
    Anna Maria Rossi
    Department of Biology, Pisa University, Pisa, Italy
    Environ Health Perspect 117:203-8. 2009
  4. pmc Normalization of low-density microarray using external spike-in controls: analysis of macrophage cell lines expression profile
    Paolo Fardin
    Laboratory of Molecular Biology, G Gaslini Institute, Genoa, Italy
    BMC Genomics 8:17. 2007
  5. pmc Combining Shapley value and statistics to the analysis of gene expression data in children exposed to air pollution
    Stefano Moretti
    Epidemiology and Biostatistics, National Cancer Research Institute, Genova, Italy
    BMC Bioinformatics 9:361. 2008
  6. ncbi request reprint Chromosomal aberrations and risk of cancer in humans: an epidemiologic perspective
    S Bonassi
    Department of Environmental Epidemiology and Biostatistics, National Cancer Research Institute, Genoa, Italy
    Cytogenet Genome Res 104:376-82. 2004
  7. ncbi request reprint Human population studies with cytogenetic biomarkers: review of the literature and future prospectives
    Stefano Bonassi
    Unit of Environmental Epidemiology and Biostatistics, National Cancer Research Institute, Genoa, Italy
    Environ Mol Mutagen 45:258-70. 2005
  8. ncbi request reprint Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project
    Stefano Bonassi
    Department of Environmental Epidemiology, Istituto Nazionale per la Ricerca sul Cancro, Largo R Benzi, Genoa, Italy
    Mutat Res 543:155-66. 2003
  9. ncbi request reprint An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans
    Stefano Bonassi
    Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
    Carcinogenesis 28:625-31. 2007
  10. pmc Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries
    Stefano Bonassi
    Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
    Carcinogenesis 29:1178-83. 2008

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Biomarkers in molecular epidemiology studies for health risk prediction
    Stefano Bonassi
    Department of Environmental Epidemiology, National Cancer Research Institute, Genoa, Italy
    Mutat Res 511:73-86. 2002
    ..By building reliable biomarker databases, a promising future is the integration of information from the genome programs to expand the scientific frontiers on etiology, health risk prediction and prevention of environmental disease...
  2. ncbi request reprint Children's exposure to environmental pollutants and biomarkers of genetic damage. II. Results of a comprehensive literature search and meta-analysis
    Monica Neri
    Unit of Epidemiology and Biostatistics, Department of Epidemiology and Prevention, National Cancer Research Institute, Largo Rosanna Benzi, 10, 16132 Genoa, Italy
    Mutat Res 612:14-39. 2006
    ....
  3. pmc Association between frequency of chromosomal aberrations and cancer risk is not influenced by genetic polymorphisms in GSTM1 and GSTT1
    Anna Maria Rossi
    Department of Biology, Pisa University, Pisa, Italy
    Environ Health Perspect 117:203-8. 2009
    ..It is presently unclear whether this association is influenced by individual susceptibility factors such as genetic polymorphisms of xenobiotic-metabolizing enzymes...
  4. pmc Normalization of low-density microarray using external spike-in controls: analysis of macrophage cell lines expression profile
    Paolo Fardin
    Laboratory of Molecular Biology, G Gaslini Institute, Genoa, Italy
    BMC Genomics 8:17. 2007
    ..Alternative approaches must be developed for microarrays where the proportion of modulated genes and their distribution are unknown and they may be biased towards up- or down-modulated trends...
  5. pmc Combining Shapley value and statistics to the analysis of gene expression data in children exposed to air pollution
    Stefano Moretti
    Epidemiology and Biostatistics, National Cancer Research Institute, Genova, Italy
    BMC Bioinformatics 9:361. 2008
    ....
  6. ncbi request reprint Chromosomal aberrations and risk of cancer in humans: an epidemiologic perspective
    S Bonassi
    Department of Environmental Epidemiology and Biostatistics, National Cancer Research Institute, Genoa, Italy
    Cytogenet Genome Res 104:376-82. 2004
    ..Finally, the most challenging perspective in the field is the passage from research to regulation, with the implementation of preventive policies based on the accumulated knowledge...
  7. ncbi request reprint Human population studies with cytogenetic biomarkers: review of the literature and future prospectives
    Stefano Bonassi
    Unit of Environmental Epidemiology and Biostatistics, National Cancer Research Institute, Genoa, Italy
    Environ Mol Mutagen 45:258-70. 2005
    ..The role of susceptibility and its potential impact on genotoxic damage are discussed with special attention to the effect of major genetic polymorphisms on the baseline frequency of CAs and micronuclei...
  8. ncbi request reprint Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project
    Stefano Bonassi
    Department of Environmental Epidemiology, Istituto Nazionale per la Ricerca sul Cancro, Largo R Benzi, Genoa, Italy
    Mutat Res 543:155-66. 2003
    ..The presence of an interaction between smoking habit and occupational exposure to genotoxic agents should be always tested...
  9. ncbi request reprint An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans
    Stefano Bonassi
    Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
    Carcinogenesis 28:625-31. 2007
    ..The current wide-spread use of the MN assay provides a valuable opportunity to apply this assay in the planning and validation of cancer surveillance and prevention programs...
  10. pmc Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries
    Stefano Bonassi
    Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
    Carcinogenesis 29:1178-83. 2008
    ..These results reinforce the evidence of a link between CA frequency and cancer risk and provide novel information on the role of aberration subclass and cancer type...
  11. ncbi request reprint No association between increased levels of high-frequency sister chromatid exchange cells (HFCs) and the risk of cancer in healthy individuals
    Stefano Bonassi
    Environmental Epidemiology and Biostatistics, National Cancer Research Institute, Genoa, Italy
    Environ Mol Mutagen 43:134-6. 2004
  12. ncbi request reprint Validation of biomarkers as early predictors of disease
    S Bonassi
    Department of Environmental Epidemiology, Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi, 10, 16132 Genova, Italy
    Mutat Res 480:349-58. 2001
    ..In general, whenever a biomarker has been determined to be a valid predictor of disease, it should be used in risk assessment and public health policy...
  13. ncbi request reprint Combining environmental exposure and genetic effect measurements in health outcome assessment
    S Bonassi
    Department of Environmental Epidemiology, Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi, 10, I 16132, Genova, Italy
    Mutat Res 428:177-85. 1999
    ....
  14. ncbi request reprint HUman MicroNucleus project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei
    S Bonassi
    Department of Environmental Epidemiology, Istituto Nazionale per la Ricerca sul Cancro, 10 Largo R Benzi, Genoa I 16132, Italy
    Environ Mol Mutagen 37:31-45. 2001
    ..Our best model, which included exposure to genotoxic factors, host factors, methods, and scoring criteria, explained 75% of the total variance, with the largest contribution attributable to laboratory methods...
  15. ncbi request reprint Analysis of correlated data in human biomonitoring studies. The case of high sister chromatid exchange frequency cells
    S Bonassi
    Department of Environmental Epidemiology and Biostatistics, National Cancer Institute, Largo Rosanna Benzi 10, 16132, Genoa, Italy
    Mutat Res 438:13-21. 1999
    ..Examples of coefficients that change across different regression models and their interpretation are discussed in detail. One model that seems particularly appropriate is the random intercepts and random slopes model...
  16. ncbi request reprint Chromosome damage and cancer risk in the workplace: the example of cytogenetic surveillance in Croatia
    Aleksandra Fucic
    Institute for Medical Research and Occupational Health, Ksaverska c 2, Zagreb, Croatia
    Toxicol Lett 172:4-11. 2007
    ..61-4.72). Recommendations for future strategies comprise the inclusion of predictive biomarkers in surveillance programs, the definition of a regulatory framework, and their possible use for the identification of individual risk profiles...
  17. ncbi request reprint The effects of GSTM1 and GSTT1 polymorphisms on micronucleus frequencies in human lymphocytes in vivo
    Micheline Kirsch-Volders
    Laboratory of Cell Genetics, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussels, Belgium
    Cancer Epidemiol Biomarkers Prev 15:1038-42. 2006
    ..79). This study confirms that pooled analyses, by increasing the statistical power, are adequate for assessing the involvement of genetic variants on genome stability and for resolving discrepancies among individual studies...
  18. doi request reprint The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: the HUMN project perspective on current status and knowledge gaps
    Nina Holland
    School of Public Health, University of California, Berkeley, CA 94720 7460, USA
    Mutat Res 659:93-108. 2008
    ....
  19. ncbi request reprint Bronchial malondialdehyde DNA adducts, tobacco smoking, and lung cancer
    Armelle Munnia
    Cancer Risk Factor Branch, CSPO Scientific Institute of Tuscany Region, Villa Delle Rose, Via Cosimo il Vecchio No 2, Florence 50139, Italy
    Free Radic Biol Med 41:1499-505. 2006
    ..Subjects who carry at least one variant allele of the CCND1 gene could accumulate DNA damage for altered cell-cycle control and reduced DNA repair proficiency...
  20. ncbi request reprint Chromosomal aberrations and cancer risk: results of a cohort study from Central Europe
    Paolo Boffetta
    International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 165:36-43. 2007
    ....
  21. doi request reprint Genetic susceptibility to malignant pleural mesothelioma and other asbestos-associated diseases
    Monica Neri
    Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
    Mutat Res 659:126-36. 2008
    ..Technical improvements such as the use of high-throughput techniques will help to identify molecular pathways regulated by candidate genes...
  22. ncbi request reprint hOGG1(326), XRCC1(399) and XRCC3(241) polymorphisms influence micronucleus frequencies in human lymphocytes in vivo
    Raluca A Mateuca
    Laboratorium voor Cellulaire Genetica, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussel, Belgium
    Mutagenesis 23:35-41. 2008
    ..Understanding the complexity of the relationships between exposure, DNA repair and MN frequencies require larger scale studies and complementary biomarkers...
  23. ncbi request reprint Polymorphisms of glutathione-S-transferase M1 and manganese superoxide dismutase are associated with the risk of malignant pleural mesothelioma
    Stefano Landi
    Department of Biology, University of Pisa, Pisa, Italy
    Int J Cancer 120:2739-43. 2007
    ..These findings, if replicated, contribute substantial evidence to the hypothesis that oxidative stress and cellular antireactive oxygen species systems are involved in the pathogenesis and in the natural history of MPM...
  24. ncbi request reprint Genetic susceptibility to malignant mesothelioma and exposure to asbestos: the influence of the familial factor
    Donatella Ugolini
    Dipartimento di Oncologia, Biologia e Genetica, University of Genoa, Genoa, Italy
    Mutat Res 658:162-71. 2008
    ..The frequent report of familial clustering was the first indication supporting the involvement of genetic factors. Therefore, we performed an extensive literature search to evaluate existing studies reporting familial cases of MM...
  25. ncbi request reprint A bibliometric analysis of scientific production in cancer molecular epidemiology
    Donatella Ugolini
    Dipartimento di Oncologia, Biologia e Genetica, University of Genoa, Genoa 16132, Italy
    Carcinogenesis 28:1774-9. 2007
    ..The main purpose of this research was to compare the scientific production in the field of cancer molecular epidemiology among countries and to evaluate the publication trend between 1995 and 2004...
  26. ncbi request reprint Searching PubMed for molecular epidemiology studies: the case of chromosome aberrations
    Donatella Ugolini
    Dipartimento di Oncologia, Biologia e Genetica, University of Genoa, Genoa, Italy
    Environ Mol Mutagen 47:227-9. 2006
    ..As regards the difficulty in identifying population studies using CA, the introduction of a specific MeSH term for chromosome aberrations when used as a biomarker would improve the search process...
  27. pmc Baseline micronuclei frequency in children: estimates from meta- and pooled analyses
    Monica Neri
    Unit of Epidemiology and Biostatistics, National Cancer Research Institute, Genoa, Italy
    Environ Health Perspect 113:1226-9. 2005
    ..No influence of sex was found. The study showed the advantage of using data from large collaborative studies and suggested a synergistic use of meta- and pooled analysis...
  28. ncbi request reprint Pooled analysis of epidemiological studies involving biological markers
    Emanuela Taioli
    Molecular and Genetic Epidemiology Unit, Ospedale Maggiore IRCCS, University of Milan, Milan, Italy
    Int J Hyg Environ Health 206:109-15. 2003
    ..Some practical indications on the conduct of a pooled analysis in molecular epidemiology is given...
  29. ncbi request reprint Implementation of a molecular epidemiology approach to human pleural malignant mesothelioma
    Riccardo Puntoni
    Environmental Epidemiology and Biostatistics, National Cancer Research Institute, Largo R Benzi 10, Genoa I 16132, Italy
    Mutat Res 544:385-96. 2003
    ..The application of innovative endpoints, such as oncoproteins in biologic fluids, genetic polimorphisms, or gene function is discussed, and relevant literature reviewed...
  30. ncbi request reprint Impact of types of lymphocyte chromosomal aberrations on human cancer risk: results from Nordic and Italian cohorts
    Lars Hagmar
    Department of Occupational and Environmental Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    Cancer Res 64:2258-63. 2004
    ..The results suggest that both DNA double-strand breaks and other initial DNA lesions responsible for CSAs and CTAs are associated with cancer risk...
  31. pmc Applying new biotechnologies to the study of occupational cancer--a workshop summary
    Mark Toraason
    National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
    Environ Health Perspect 112:413-6. 2004
    ..The workshop focused on identifying and interpreting markers for early biologic effect and inherited modifiers of risk...
  32. ncbi request reprint Comparison of DNA adduct levels in nasal mucosa, lymphocytes and bronchial mucosa of cigarette smokers and interaction with metabolic gene polymorphisms
    Marco Peluso
    Cancer Risk Factor Branch, Molecular Biology Laboratory, CSPO, Scientific Institute of Tuscany, Florence, Italy
    Carcinogenesis 25:2459-65. 2004
    ..Nasal mucosa brushing proved to be a suitable procedure for the (32)P-labelling assay and its use in population studies should be further explored...
  33. pmc Chromosomal aberrations in lymphocytes of healthy subjects and risk of cancer
    Pavel Rossner
    Department of Genetic Ecotoxicology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, and Health Institute of Central Bohemia, Videnska 1083, 142 20 Prague 4, Czech Republic
    Environ Health Perspect 113:517-20. 2005
    ..This study contributes to validation of CA as a predictive marker of cancer risk, in particular, of stomach cancer; the association between CA frequency and cancer risk might be limited to chromosome-type aberrations...
  34. ncbi request reprint Children's exposure to environmental pollutants and biomarkers of genetic damage. I. Overview and critical issues
    Monica Neri
    Unit of Epidemiology and Biostatistics, National Cancer Research Institute, Genoa, Italy
    Mutat Res 612:1-13. 2006
    ..Examples of field studies that are focused on the effects of pesticides, air pollution and formaldehyde are used to illustrate advantages and limitations of biomarker studies in children...
  35. ncbi request reprint Pleural malignant mesothelioma, genetic susceptibility and asbestos exposure
    Monica Neri
    Unit of Epidemiology and Biostatistics, National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Mutat Res 592:36-44. 2005
    ..In conclusion, these results strengthen the hypothesis that individual susceptibility to MM can be modulated by the interaction between polymorphic genes involved in the metabolism and the intensity of asbestos exposure...
  36. ncbi request reprint Detection of MYCN amplification and chromosome 1p36 loss in neuroblastoma by cDNA microarray comparative genomic hybridization
    Paola Scaruffi
    Laboratory of Neuroblastoma, National Cancer Research Institute IST, Genoa, Italy
    Mol Diagn 8:93-100. 2004
    ..We have developed a microarray-based comparative genomic hybridization (CGH) approach to identify MYCN gene amplification and 1p36 chromosome loss, two markers of tumor aggressiveness in neuroblastoma...
  37. doi request reprint Identification of low intratumoral gene expression heterogeneity in neuroblastic tumors by genome-wide expression analysis and game theory
    Domenico Albino
    Laboratory of Italian Neuroblastoma Foundation, National Cancer Research Institute, Genoa, Italy
    Cancer 113:1412-22. 2008
    ..NT gene expression profiles reported so far have not taken into account the cellular components. The authors reported the genome-wide expression analysis of whole tumors and microdissected Nb and SS cells...
  38. ncbi request reprint Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project
    Michael Fenech
    CSIRO Health Sciences and Nutrition, Adelaide, SA, Australia
    Mutat Res 534:45-64. 2003
    ....
  39. ncbi request reprint Methodological issues in pooled analysis of biomarker studies
    Emanuela Taioli
    Molecular and Genetic Epidemiology Unit, Ospedale Maggiore IRCCS, University of Milan, Via F Sforza, 28, Italy
    Mutat Res 512:85-92. 2002
    ..Pooled analysis seems to provide a relevant improvement over meta-analysis in molecular epidemiology studies, though more research on methodology is needed...
  40. ncbi request reprint Validation of micronuclei frequency in peripheral blood lymphocytes as early cancer risk biomarker in a nested case-control study
    Elena Murgia
    Department of Biology, Pisa University, via Derna 2, Pisa, Italy
    Mutat Res 639:27-34. 2008
    ..001). These findings provide strong evidence that MN frequency assessed in PBL of disease-free subjects is a good predictor of cancer death risk, evaluated by a nested case-control study performed 14 years after the original recruitment...
  41. ncbi request reprint Micronucleus frequency is increased in peripheral blood lymphocytes of nuclear power plant workers
    Valeria B Hadjidekova
    Laboratory of Radiation Mutagenesis and Embryology, National Center Radiobiology and Radiation Protection, Bul Kl Ochridski 132, 1756 Sofia, Bulgaria
    Radiat Res 160:684-90. 2003
    ....
  42. ncbi request reprint Micronuclei frequency in children exposed to environmental mutagens: a review
    Monica Neri
    Environmental Epidemiology and Biostatistics, National Cancer Research Institute, Largo R Benzi 10, 16132 Genoa, Italy
    Mutat Res 544:243-54. 2003
    ..This review confirmed the usefulness of MN assay in biomonitoring studies conducted in children, revealing that in many circumstances investigating children increases the sensitivity of the study, even with low dose exposures...
  43. ncbi request reprint Prealbumin serum concentrations as a useful tool in the assessment of malnutrition in hospitalized patients
    Gianluigi Devoto
    Laboratory Department, Ospedale di Lavagna, Lavagna, Italy
    Clin Chem 52:2281-5. 2006
    ..Prealbumin (PAB) is a potential useful PEM marker because its serum concentrations are closely related to early changes in nutritional status...
  44. ncbi request reprint Pre-operative pulmonary rehabilitation and surgery for lung cancer
    Alfredo Cesario
    Lung Cancer 57:118-9. 2007
  45. ncbi request reprint Post-operative respiratory rehabilitation after lung resection for non-small cell lung cancer
    Alfredo Cesario
    Department of Surgical Sciences, Division of Thoracic Surgery, Catholic University, Rome
    Lung Cancer 57:175-80. 2007
    ..To investigate the efficacy of an inpatient Pulmonary Rehabilitation program (i-PR) after lung resection (LR) for Non-Small Cell Lung Cancer (NSCLC)...
  46. ncbi request reprint Harmonisation of the micronucleus assay in human buccal cells--a Human Micronucleus (HUMN) project (www.humn.org) initiative commencing in 2007
    Michael Fenech
    CSIRO Human Nutrition, Adelaide, South Australia 5000, Australia
    Mutagenesis 22:3-4. 2007
  47. ncbi request reprint [Depleted uranium: the Signum Project]
    Stefano Bonassi
    Epidemiol Prev 31:6. 2007