Research Topics
| S BonassiSummaryAffiliation: National Cancer Research Institute Country: Italy Publications
| Collaborators
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Detail Information
Publications
Biomarkers in molecular epidemiology studies for health risk predictionStefano Bonassi
Department of Environmental Epidemiology, National Cancer Research Institute, Genoa, Italy
Mutat Res 511:73-86. 2002..By building reliable biomarker databases, a promising future is the integration of information from the genome programs to expand the scientific frontiers on etiology, health risk prediction and prevention of environmental disease...- Children's exposure to environmental pollutants and biomarkers of genetic damage. II. Results of a comprehensive literature search and meta-analysisMonica Neri
Unit of Epidemiology and Biostatistics, Department of Epidemiology and Prevention, National Cancer Research Institute, Largo Rosanna Benzi, 10, 16132 Genoa, Italy
Mutat Res 612:14-39. 2006.... 
Normalization of low-density microarray using external spike-in controls: analysis of macrophage cell lines expression profilePaolo Fardin
Laboratory of Molecular Biology, G Gaslini Institute, Genoa, Italy
BMC Genomics 8:17. 2007..Alternative approaches must be developed for microarrays where the proportion of modulated genes and their distribution are unknown and they may be biased towards up- or down-modulated trends...- Combining Shapley value and statistics to the analysis of gene expression data in children exposed to air pollutionStefano Moretti
Epidemiology and Biostatistics, National Cancer Research Institute, Genova, Italy
BMC Bioinformatics 9:361. 2008.... - Chromosomal aberrations and risk of cancer in humans: an epidemiologic perspectiveS Bonassi
Department of Environmental Epidemiology and Biostatistics, National Cancer Research Institute, Genoa, Italy
Cytogenet Genome Res 104:376-82. 2004..Finally, the most challenging perspective in the field is the passage from research to regulation, with the implementation of preventive policies based on the accumulated knowledge... - Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus projectStefano Bonassi
Department of Environmental Epidemiology, Istituto Nazionale per la Ricerca sul Cancro, Largo R Benzi, Genoa, Italy
Mutat Res 543:155-66. 2003..The presence of an interaction between smoking habit and occupational exposure to genotoxic agents should be always tested... - Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countriesStefano Bonassi
Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
Carcinogenesis 29:1178-83. 2008..These results reinforce the evidence of a link between CA frequency and cancer risk and provide novel information on the role of aberration subclass and cancer type... - Human population studies with cytogenetic biomarkers: review of the literature and future prospectivesStefano Bonassi
Unit of Environmental Epidemiology and Biostatistics, National Cancer Research Institute, Genoa, Italy
Environ Mol Mutagen 45:258-70. 2005..The role of susceptibility and its potential impact on genotoxic damage are discussed with special attention to the effect of major genetic polymorphisms on the baseline frequency of CAs and micronuclei... - An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humansStefano Bonassi
Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
Carcinogenesis 28:625-31. 2007..The current wide-spread use of the MN assay provides a valuable opportunity to apply this assay in the planning and validation of cancer surveillance and prevention programs... - No association between increased levels of high-frequency sister chromatid exchange cells (HFCs) and the risk of cancer in healthy individualsStefano Bonassi
Environmental Epidemiology and Biostatistics, National Cancer Research Institute, Genoa, Italy
Environ Mol Mutagen 43:134-6. 2004 - Validation of biomarkers as early predictors of diseaseS Bonassi
Department of Environmental Epidemiology, Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi, 10, 16132 Genova, Italy
Mutat Res 480:349-58. 2001..In general, whenever a biomarker has been determined to be a valid predictor of disease, it should be used in risk assessment and public health policy... - Combining environmental exposure and genetic effect measurements in health outcome assessmentS Bonassi
Department of Environmental Epidemiology, Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi, 10, I 16132, Genova, Italy
Mutat Res 428:177-85. 1999.... - HUman MicroNucleus project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronucleiS Bonassi
Department of Environmental Epidemiology, Istituto Nazionale per la Ricerca sul Cancro, 10 Largo R Benzi, Genoa I 16132, Italy
Environ Mol Mutagen 37:31-45. 2001..Our best model, which included exposure to genotoxic factors, host factors, methods, and scoring criteria, explained 75% of the total variance, with the largest contribution attributable to laboratory methods... - Analysis of correlated data in human biomonitoring studies. The case of high sister chromatid exchange frequency cellsS Bonassi
Department of Environmental Epidemiology and Biostatistics, National Cancer Institute, Largo Rosanna Benzi 10, 16132, Genoa, Italy
Mutat Res 438:13-21. 1999..Examples of coefficients that change across different regression models and their interpretation are discussed in detail. One model that seems particularly appropriate is the random intercepts and random slopes model... - Chromosome damage and cancer risk in the workplace: the example of cytogenetic surveillance in CroatiaAleksandra Fucic
Institute for Medical Research and Occupational Health, Ksaverska c 2, Zagreb, Croatia
Toxicol Lett 172:4-11. 2007..61-4.72). Recommendations for future strategies comprise the inclusion of predictive biomarkers in surveillance programs, the definition of a regulatory framework, and their possible use for the identification of individual risk profiles... - Searching PubMed for molecular epidemiology studies: the case of chromosome aberrationsDonatella Ugolini
Dipartimento di Oncologia, Biologia e Genetica, University of Genoa, Genoa, Italy
Environ Mol Mutagen 47:227-9. 2006..As regards the difficulty in identifying population studies using CA, the introduction of a specific MeSH term for chromosome aberrations when used as a biomarker would improve the search process... - The effects of GSTM1 and GSTT1 polymorphisms on micronucleus frequencies in human lymphocytes in vivoMicheline Kirsch-Volders
Laboratory of Cell Genetics, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussels, Belgium
Cancer Epidemiol Biomarkers Prev 15:1038-42. 2006..79). This study confirms that pooled analyses, by increasing the statistical power, are adequate for assessing the involvement of genetic variants on genome stability and for resolving discrepancies among individual studies... 
The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: the HUMN project perspective on current status and knowledge gapsNina Holland
School of Public Health, University of California, Berkeley, CA 94720 7460, USA
Mutat Res 659:93-108. 2008....- Genetic susceptibility to malignant pleural mesothelioma and other asbestos-associated diseasesMonica Neri
Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
Mutat Res 659:126-36. 2008..Technical improvements such as the use of high-throughput techniques will help to identify molecular pathways regulated by candidate genes... - Bronchial malondialdehyde DNA adducts, tobacco smoking, and lung cancerArmelle Munnia
Cancer Risk Factor Branch, CSPO-Scientific Institute of Tuscany Region, Villa Delle Rose, Via Cosimo il Vecchio No. 2, Florence 50139, Italy
Free Radic Biol Med 41:1499-505. 2006..Subjects who carry at least one variant allele of the CCND1 gene could accumulate DNA damage for altered cell-cycle control and reduced DNA repair proficiency... - Chromosomal aberrations and cancer risk: results of a cohort study from Central EuropePaolo Boffetta
International Agency for Research on Cancer, Lyon, France
Am J Epidemiol 165:36-43. 2007.... - hOGG1(326), XRCC1(399) and XRCC3(241) polymorphisms influence micronucleus frequencies in human lymphocytes in vivoRaluca A Mateuca
Laboratorium voor Cellulaire Genetica, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussel, Belgium
Mutagenesis 23:35-41. 2008..Understanding the complexity of the relationships between exposure, DNA repair and MN frequencies require larger scale studies and complementary biomarkers... - Genetic susceptibility to malignant mesothelioma and exposure to asbestos: the influence of the familial factorDonatella Ugolini
Dipartimento di Oncologia, Biologia e Genetica, University of Genoa, Genoa, Italy
Mutat Res 658:162-71. 2008..The frequent report of familial clustering was the first indication supporting the involvement of genetic factors. Therefore, we performed an extensive literature search to evaluate existing studies reporting familial cases of MM... - Polymorphisms of glutathione-S-transferase M1 and manganese superoxide dismutase are associated with the risk of malignant pleural mesotheliomaStefano Landi
Department of Biology, University of Pisa, Pisa, Italy
Int J Cancer 120:2739-43. 2007..These findings, if replicated, contribute substantial evidence to the hypothesis that oxidative stress and cellular antireactive oxygen species systems are involved in the pathogenesis and in the natural history of MPM... - Baseline micronuclei frequency in children: estimates from meta- and pooled analysesMonica Neri
Unit of Epidemiology and Biostatistics, National Cancer Research Institute, Genoa, Italy
Environ Health Perspect 113:1226-9. 2005..No influence of sex was found. The study showed the advantage of using data from large collaborative studies and suggested a synergistic use of meta- and pooled analysis... - Pooled analysis of epidemiological studies involving biological markersEmanuela Taioli
Molecular and Genetic Epidemiology Unit, Ospedale Maggiore IRCCS, University of Milan, Milan, Italy
Int J Hyg Environ Health 206:109-15. 2003..Some practical indications on the conduct of a pooled analysis in molecular epidemiology is given... - Implementation of a molecular epidemiology approach to human pleural malignant mesotheliomaRiccardo Puntoni
Environmental Epidemiology and Biostatistics, National Cancer Research Institute, Largo R Benzi 10, Genoa I 16132, Italy
Mutat Res 544:385-96. 2003..The application of innovative endpoints, such as oncoproteins in biologic fluids, genetic polimorphisms, or gene function is discussed, and relevant literature reviewed... - Impact of types of lymphocyte chromosomal aberrations on human cancer risk: results from Nordic and Italian cohortsLars Hagmar
Department of Occupational and Environmental Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
Cancer Res 64:2258-63. 2004..The results suggest that both DNA double-strand breaks and other initial DNA lesions responsible for CSAs and CTAs are associated with cancer risk... - Applying new biotechnologies to the study of occupational cancer--a workshop summaryMark Toraason
National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Environ Health Perspect 112:413-6. 2004..The workshop focused on identifying and interpreting markers for early biologic effect and inherited modifiers of risk... - A bibliometric analysis of scientific production in cancer molecular epidemiologyDonatella Ugolini
Dipartimento di Oncologia, Biologia e Genetica, University of Genoa, Genoa 16132, Italy
Carcinogenesis 28:1774-9. 2007..The main purpose of this research was to compare the scientific production in the field of cancer molecular epidemiology among countries and to evaluate the publication trend between 1995 and 2004... - Comparison of DNA adduct levels in nasal mucosa, lymphocytes and bronchial mucosa of cigarette smokers and interaction with metabolic gene polymorphismsMarco Peluso
Cancer Risk Factor Branch, Molecular Biology Laboratory, CSPO, Scientific Institute of Tuscany, Florence, Italy
Carcinogenesis 25:2459-65. 2004..Nasal mucosa brushing proved to be a suitable procedure for the (32)P-labelling assay and its use in population studies should be further explored... - Chromosomal aberrations in lymphocytes of healthy subjects and risk of cancerPavel Rossner
Department of Genetic Ecotoxicology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, and Health Institute of Central Bohemia, Videnska 1083, 142-20 Prague 4, Czech Republic
Environ Health Perspect 113:517-20. 2005..This study contributes to validation of CA as a predictive marker of cancer risk, in particular, of stomach cancer; the association between CA frequency and cancer risk might be limited to chromosome-type aberrations... - Pleural malignant mesothelioma, genetic susceptibility and asbestos exposureMonica Neri
Unit of Epidemiology and Biostatistics, National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy
Mutat Res 592:36-44. 2005..In conclusion, these results strengthen the hypothesis that individual susceptibility to MM can be modulated by the interaction between polymorphic genes involved in the metabolism and the intensity of asbestos exposure... - Children's exposure to environmental pollutants and biomarkers of genetic damage. I. Overview and critical issuesMonica Neri
Unit of Epidemiology and Biostatistics, National Cancer Research Institute, Genoa, Italy
Mutat Res 612:1-13. 2006..Examples of field studies that are focused on the effects of pesticides, air pollution and formaldehyde are used to illustrate advantages and limitations of biomarker studies in children... - Identification of low intratumoral gene expression heterogeneity in neuroblastic tumors by genome-wide expression analysis and game theoryDomenico Albino
Laboratory of Italian Neuroblastoma Foundation, National Cancer Research Institute, Genoa, Italy
Cancer 113:1412-22. 2008..NT gene expression profiles reported so far have not taken into account the cellular components. The authors reported the genome-wide expression analysis of whole tumors and microdissected Nb and SS cells... - Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN projectMichael Fenech
CSIRO Health Sciences and Nutrition, Adelaide, SA, Australia
Mutat Res 534:45-64. 2003.... - Methodological issues in pooled analysis of biomarker studiesEmanuela Taioli
Molecular and Genetic Epidemiology Unit, Ospedale Maggiore IRCCS, University of Milan, Via F Sforza, 28, Italy
Mutat Res 512:85-92. 2002..Pooled analysis seems to provide a relevant improvement over meta-analysis in molecular epidemiology studies, though more research on methodology is needed... - Micronucleus frequency is increased in peripheral blood lymphocytes of nuclear power plant workersValeria B Hadjidekova
Laboratory of Radiation Mutagenesis and Embryology, National Center Radiobiology and Radiation Protection, Bul. Kl. Ochridski 132, 1756 Sofia, Bulgaria
Radiat Res 160:684-90. 2003.... - Micronuclei frequency in children exposed to environmental mutagens: a reviewMonica Neri
Environmental Epidemiology and Biostatistics, National Cancer Research Institute, Largo R. Benzi 10, 16132 Genoa, Italy
Mutat Res 544:243-54. 2003..This review confirmed the usefulness of MN assay in biomonitoring studies conducted in children, revealing that in many circumstances investigating children increases the sensitivity of the study, even with low dose exposures... - [Depleted uranium: the Signum Project]Stefano Bonassi
Epidemiol Prev 31:6. 2007 - Pre-operative pulmonary rehabilitation and surgery for lung cancerAlfredo Cesario
Lung Cancer 57:118-9. 2007 - Post-operative respiratory rehabilitation after lung resection for non-small cell lung cancerAlfredo Cesario
Department of Surgical Sciences, Division of Thoracic Surgery, Catholic University, Rome
Lung Cancer 57:175-80. 2007..To investigate the efficacy of an inpatient Pulmonary Rehabilitation program (i-PR) after lung resection (LR) for Non-Small Cell Lung Cancer (NSCLC)... - Harmonisation of the micronucleus assay in human buccal cells--a Human Micronucleus (HUMN) project (www.humn.org) initiative commencing in 2007Michael Fenech
CSIRO Human Nutrition, Adelaide, South Australia 5000, Australia
Mutagenesis 22:3-4. 2007 - Prealbumin serum concentrations as a useful tool in the assessment of malnutrition in hospitalized patientsGianluigi Devoto
Laboratory Department, Ospedale di Lavagna, Lavagna, Italy
Clin Chem 52:2281-5. 2006.... - Detection of MYCN amplification and chromosome 1p36 loss in neuroblastoma by cDNA microarray comparative genomic hybridizationPaola Scaruffi
Laboratory of Neuroblastoma, National Cancer Research Institute (IST, Genoa, Italy
Mol Diagn 8:93-100. 2004..7% and specificity of 90.9% to detect MYCN amplification. DISCUSSION: Our results demonstrated that the microarray CGH can be efficiently applied to study DNA gain and loss of specific chromosome regions... - Validation of micronuclei frequency in peripheral blood lymphocytes as early cancer risk biomarker in a nested case-control studyElena Murgia
Department of Biology, Pisa University, via Derna 2, Pisa, Italy
Mutat Res 639:27-34. 2008..001). These findings provide strong evidence that MN frequency assessed in PBL of disease-free subjects is a good predictor of cancer death risk, evaluated by a nested case-control study performed 14 years after the original recruitment...