Claudia Bolognesi

Summary

Affiliation: National Cancer Research Institute
Country: Italy

Publications

  1. ncbi Bioindicators in monitoring long term genotoxic impact of oil spill: Haven case study
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, National Cancer Research Institute, L go Rosanna Benzi, 10, 16132 Genoa, Italy
    Mar Environ Res 62:S287-91. 2006
  2. doi Micronucleus assay in aquatic animals
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, National Institute for Research on Cancer, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Mutagenesis 26:205-13. 2011
  3. doi Mussel micronucleus cytome assay
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Azienda Ospedaliera Universitaria San Martino IST, Istituto Nazionale Ricerca sul Cancro, Genova, Italy
    Nat Protoc 7:1125-37. 2012
  4. ncbi Assessment of micronuclei induction in peripheral erythrocytes of fish exposed to xenobiotics under controlled conditions
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, National Institute for Research on Cancer, L go Rosanna Benzi 10, 16132 Genoa, Italy
    Aquat Toxicol 78:S93-8. 2006
  5. ncbi [Biomonitoring of nurses occupationally exposed to antineoplastic drugs: the IMEPA Project]
    Claudia Bolognesi
    Struttura di cancerogenesi ambientale, Istituto Nazionale per la Ricerca sul Cancro, Genova
    Epidemiol Prev 29:91-5. 2005
  6. ncbi Genotoxicity biomarkers in Mytilus galloprovincialis: wild versus caged mussels
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, National Cancer Research Institute, Largo R Benzi 10, 16132 Genova, Italy
    Mutat Res 552:153-62. 2004
  7. ncbi Cytogenetic biomonitoring of a floriculturist population in Italy: micronucleus analysis by fluorescence in situ hybridization (FISH) with an all-chromosome centromeric probe
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, National Cancer Research Institute, Largo R Benzi 10, 16132 Genoa, Italy
    Mutat Res 557:109-17. 2004
  8. ncbi Genotoxicity of pesticides: a review of human biomonitoring studies
    Claudia Bolognesi
    Toxicological Evaluation Unit, National Cancer Research Institute, Genova, Italy
    Mutat Res 543:251-72. 2003
  9. ncbi A molecular epidemiology case control study on pleural malignant mesothelioma
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, National Cancer Research Institute, L go Rosanna Benzsi, 10 Genoa, Italy 16132
    Cancer Epidemiol Biomarkers Prev 14:1741-6. 2005
  10. ncbi High frequency of micronuclei in peripheral blood lymphocytes as index of susceptibility to pleural malignant mesothelioma
    Claudia Bolognesi
    National Cancer Research Institute, Toxicological Evaluation, 16132 Genoa, Italy
    Cancer Res 62:5418-9. 2002

Detail Information

Publications29

  1. ncbi Bioindicators in monitoring long term genotoxic impact of oil spill: Haven case study
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, National Cancer Research Institute, L go Rosanna Benzi, 10, 16132 Genoa, Italy
    Mar Environ Res 62:S287-91. 2006
    ..5 vs 0.7) in a further sampling in 1998. Statistically significant increase of DNA damage and MN frequency was observed in caged oysters in different areas of the wreck in a biomonitoring carried out in 2001...
  2. doi Micronucleus assay in aquatic animals
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, National Institute for Research on Cancer, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Mutagenesis 26:205-13. 2011
    ..Further validation studies are needed in order to better characterise the different types of nuclear alterations and to clarify the role of biotic and abiotic factors in interspecies and inter-individual variability...
  3. doi Mussel micronucleus cytome assay
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Azienda Ospedaliera Universitaria San Martino IST, Istituto Nazionale Ricerca sul Cancro, Genova, Italy
    Nat Protoc 7:1125-37. 2012
    ..The complete procedure requires approximately 10 h for each experimental point/sampling station (ten animals)...
  4. ncbi Assessment of micronuclei induction in peripheral erythrocytes of fish exposed to xenobiotics under controlled conditions
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, National Institute for Research on Cancer, L go Rosanna Benzi 10, 16132 Genoa, Italy
    Aquat Toxicol 78:S93-8. 2006
    ..The study results revealed that micronucleus test, as an index of cumulative exposure, appears to be a sensitive model to evaluate genotoxic compounds in fish under controlled conditions...
  5. ncbi [Biomonitoring of nurses occupationally exposed to antineoplastic drugs: the IMEPA Project]
    Claudia Bolognesi
    Struttura di cancerogenesi ambientale, Istituto Nazionale per la Ricerca sul Cancro, Genova
    Epidemiol Prev 29:91-5. 2005
    ..To develop a multiple-endpoint monitoring system in order to assess and minimize long term risks in hospital nurses exposed to antiblastic drugs...
  6. ncbi Genotoxicity biomarkers in Mytilus galloprovincialis: wild versus caged mussels
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, National Cancer Research Institute, Largo R Benzi 10, 16132 Genova, Italy
    Mutat Res 552:153-62. 2004
    ..Endogenous and exogenous factors, such as change of pollutant input levels or compositions, could be considered the cause of such variability...
  7. ncbi Cytogenetic biomonitoring of a floriculturist population in Italy: micronucleus analysis by fluorescence in situ hybridization (FISH) with an all-chromosome centromeric probe
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, National Cancer Research Institute, Largo R Benzi 10, 16132 Genoa, Italy
    Mutat Res 557:109-17. 2004
    ..These results suggest a potential human hazard associated with the exposure to this class of aneuploidy-inducing carcinogens...
  8. ncbi Genotoxicity of pesticides: a review of human biomonitoring studies
    Claudia Bolognesi
    Toxicological Evaluation Unit, National Cancer Research Institute, Genova, Italy
    Mutat Res 543:251-72. 2003
    ..Data available at present on the effect of genetic polymorphism on susceptibility to pesticides does not allow any conclusion...
  9. ncbi A molecular epidemiology case control study on pleural malignant mesothelioma
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, National Cancer Research Institute, L go Rosanna Benzsi, 10 Genoa, Italy 16132
    Cancer Epidemiol Biomarkers Prev 14:1741-6. 2005
    ..Evidence of cytogenetic damage revealed as micronuclei frequency in mesothelioma cancer patients could be related to exogenous and endogenous cofactors besides asbestos exposure...
  10. ncbi High frequency of micronuclei in peripheral blood lymphocytes as index of susceptibility to pleural malignant mesothelioma
    Claudia Bolognesi
    National Cancer Research Institute, Toxicological Evaluation, 16132 Genoa, Italy
    Cancer Res 62:5418-9. 2002
    ..The presence of high frequency of MN in peripheral blood lymphocytes of patients with MM could represent a useful index of individual susceptibility to this tumor...
  11. ncbi Micronucleus monitoring of a floriculturist population from western Liguria, Italy
    Claudia Bolognesi
    Unità di Valutazione Tossicologica, Istituto Nazionale per la Ricerca sul Cancro, IST, Largo R Benzi 10, 16132 Genoa, Italy
    Mutagenesis 17:391-7. 2002
    ..Workers not using protective measures during high exposure activities showed an increase in MN frequency. Our findings suggest a potential genotoxic risk due to pesticide exposure...
  12. ncbi Pleural malignant mesothelioma, genetic susceptibility and asbestos exposure
    Monica Neri
    Unit of Epidemiology and Biostatistics, National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Mutat Res 592:36-44. 2005
    ..In conclusion, these results strengthen the hypothesis that individual susceptibility to MM can be modulated by the interaction between polymorphic genes involved in the metabolism and the intensity of asbestos exposure...
  13. doi Micronuclei and pesticide exposure
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Mutagenesis 26:19-26. 2011
    ....
  14. ncbi An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans
    Stefano Bonassi
    Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
    Carcinogenesis 28:625-31. 2007
    ..The current wide-spread use of the MN assay provides a valuable opportunity to apply this assay in the planning and validation of cancer surveillance and prevention programs...
  15. doi The micronucleus assay as a biological dosimeter in hospital workers exposed to low doses of ionizing radiation
    Monica Ropolo
    IRCCS Azienda Ospedaliera Universitaria San Martino IST, Istituto Nazionale Ricerca sul Cancro, Genova, Italy
    Mutat Res 747:7-13. 2012
    ..Our study shows the sensitivity of the MN test in the detection of cytogenetic effects of cumulative exposure levels, suggesting the potential usefulness of this assay in providing a biological index in medical surveillance programs...
  16. ncbi Comet and micronucleus assays in zebra mussel cells for genotoxicity assessment of surface drinking water treated with three different disinfectants
    Claudia Bolognesi
    Unità di Cancerogenesi Ambientale, Istituto Nazionale per la Ricerca sul Cancro Largo R Benzi 10, 16132 Genova, Italy
    Sci Total Environ 333:127-36. 2004
    ..PAA did not induce either clastogenic/aneugenic effects or DNA damage on this bioindicator...
  17. doi Occupational exposure to formaldehyde and biological monitoring of Research Institute workers
    Mauro Pala
    Department of Epidemiology and Prevention, Unit of Environmental Chemistry and Carcinogenesis, National Cancer Research Institute, Genoa, Italy
    Cancer Detect Prev 32:121-6. 2008
    ..The aim of this study was to verify the presence of a relationship between formaldehyde exposure in the work environment with biological markers of exposure and of effect...
  18. doi The HUMNxl scoring criteria for different cell types and nuclear anomalies in the buccal micronucleus cytome assay - an update and expanded photogallery
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, IRCCS Azienda Ospedaliera Universitaria San Martino IST Istituto Nazionale Ricerca sul Cancro, Largo Rosanna Benzi 10, Genova, Italy Electronic address
    Mutat Res 753:100-13. 2013
    ..humn.org) to standardize the application of micronucleus assay for use in human biomonitoring and to update procedures as knowledge on mechanisms and technical capability improvements. ..
  19. doi Micronucleus assay in human cells: lymphocytes and buccal cells
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, IRCCS Azienda Ospedaliera, Universitaria San Martino IST Istituto Nazionale Ricerca sul Cancro, Genova, Italy
    Methods Mol Biol 1044:191-207. 2013
    ..BMNCyt protocol reports the established method for sample processing, slide preparation, and scoring. ..
  20. ncbi Genotoxic action of cycloplatam, a new platinum antitumor drug, on mammalian cells in vivo and in vitro
    Armen Nersesyan
    Cancer Research Center, Yerevan, Armenia
    Chemotherapy 49:132-7. 2003
    ..In vitro data evidenced that CP is more toxic and genotoxic to human cells than cisplatin. The evidence of a MN-induced activity of an antitumor drug suggests a potential risk for long-time survivors...
  21. doi Genetic susceptibility to benzene toxicity in humans
    Seymour Garte
    Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Toxicol Environ Health A 71:1482-9. 2008
    ..The three locus genotype predicted to produce the highest level of toxicity, based on metabolic pathways, produced a significant 5.5-fold higher level of DNA-SSB than did the genotype predicted to yield the least genotoxicity...
  22. ncbi Biomarkers of exposure and effect in Bulgarian petrochemical workers exposed to benzene
    Seymour Garte
    School of Public Health, UMDNJ, 330 George St, New Brunswick, NJ 08903, USA
    Chem Biol Interact 153:247-51. 2005
    ..NQO1 genotype had a significant effect on SSB. We conclude that the pathways for these metabolites may be distinct from those involved in some forms of genotoxic damage induced by benzene...
  23. ncbi DNA damage in eelpout (Zoarces viviparus) from Göteborg harbour
    Giada Frenzilli
    Department of Human Morphology and Applied Biology, University of Pisa, Via Volta 4, 56126 Pisa, Italy
    Mutat Res 552:187-95. 2004
    ..The levels of apoptic cells did not show any marked variations, but a significant recovery was observed in fish from the oil impacted site 5 months after the spill...
  24. ncbi [Occupational exposure to antineoplastic drugs in a hospital setting: biological and environmental monitoring]
    Anna Barbieri
    Servizio di Sicurezza, Igiene e Medicina del Lavoro, Universita di Bologna, Ospedale Sant Orsola Malpighi
    Epidemiol Prev 29:87-90. 2005
    ..To estimate the occupational exposure of hospital personnel handling antineoplastics drugs using a highly sensitive and specific analitycal method in biological and environmental samples...
  25. ncbi The use of S-phenylmercapturic acid as a biomarker in molecular epidemiology studies of benzene
    Peter B Farmer
    Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, University Road, Leicester LE1 7RH, UK
    Chem Biol Interact 153:97-102. 2005
    ..55 ppm) benzene). All three biomarkers were positively correlated with smoking as measured by urinary cotinine)...
  26. ncbi Cytogenetic toxicity of cycloplatam in human lymphocytes: detection by the micronucleus test and fluorescence in situ hybridization
    Armen Nersesyan
    Cancer Research Center, Yerevan, Armenia
    Anticancer Drugs 17:289-95. 2006
    ..Cycloplatam induces one type of MN and it could be considered a clastogenic agent, whereas cisplatin and carboplatin appear to induce both chromosome breakage and numerical chromosomal abnormalities...
  27. ncbi Harmonisation of the micronucleus assay in human buccal cells--a Human Micronucleus (HUMN) project (www.humn.org) initiative commencing in 2007
    Michael Fenech
    CSIRO Human Nutrition, Adelaide, South Australia 5000, Australia
    Mutagenesis 22:3-4. 2007
  28. ncbi Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project
    Michael Fenech
    CSIRO Health Sciences and Nutrition, Adelaide, SA, Australia
    Mutat Res 534:45-64. 2003
    ....
  29. doi The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: the HUMN project perspective on current status and knowledge gaps
    Nina Holland
    School of Public Health, University of California, Berkeley, CA 94720 7460, USA
    Mutat Res 659:93-108. 2008
    ....