A Antinori

Summary

Affiliation: National Institute for Infectious Diseases
Country: Italy

Publications

  1. pmc Long-term CD4+ T-cell count evolution after switching from regimens including HIV nucleoside reverse transcriptase inhibitors (NRTI) plus protease inhibitors to regimens containing NRTI plus non-NRTI or only NRTI
    Carlo Torti
    University of Brescia, Italy
    BMC Infect Dis 11:23. 2011
  2. ncbi request reprint Cross-resistance among nonnucleoside reverse transcriptase inhibitors limits recycling efavirenz after nevirapine failure
    Andrea Antinori
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, 00149 Rome, Italy
    AIDS Res Hum Retroviruses 18:835-8. 2002
  3. ncbi request reprint Better response to chemotherapy and prolonged survival in AIDS-related lymphomas responding to highly active antiretroviral therapy
    A Antinori
    National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy
    AIDS 15:1483-91. 2001
  4. ncbi request reprint Clinical epidemiology and survival of progressive multifocal leukoencephalopathy in the era of highly active antiretroviral therapy: data from the Italian Registry Investigative Neuro AIDS (IRINA)
    Andrea Antinori
    Clinical Department, Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, IRCCS, Roma, Italy
    J Neurovirol 9:47-53. 2003
  5. ncbi request reprint Relative prognostic value of self-reported adherence and plasma NNRTI/PI concentrations to predict virological rebound in patients initially responding to HAART
    Andrea Antinori
    Istituto Nazionale per le Malattie Infettive, L Spallanzani IRCCS, Roma, Italy
    Antivir Ther 9:291-6. 2004
  6. ncbi request reprint Antiviral efficacy and genotypic resistance patterns of combination therapy with stavudine/tenofovir in highly active antiretroviral therapy experienced patients
    Andrea Antinori
    National Institute for Infectious Diseases L Spallanzani IRCCS, Roma
    Antivir Ther 11:233-43. 2006
  7. ncbi request reprint Virological response to salvage therapy in HIV-infected persons carrying the reverse transcriptase K65R mutation
    Andrea Antinori
    National Institute for Infectious Diseases L Spallanzani IRCCS, Roma, Italy
    Antivir Ther 12:1175-83. 2007
  8. ncbi request reprint Short Communication: Yersinia pseudotuberculosis septicemia in an HIV-infected patient failed HAART
    Andrea Antinori
    Dipartimento Clinico, INMI Lazzaro Spallanzani IRCCS, Rome, Italy
    AIDS Res Hum Retroviruses 20:709-10. 2004
  9. ncbi request reprint Prevalence, associated factors, and prognostic determinants of AIDS-related toxoplasmic encephalitis in the era of advanced highly active antiretroviral therapy
    Andrea Antinori
    Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    Clin Infect Dis 39:1681-91. 2004
  10. ncbi request reprint Factors influencing virological response to antiretroviral drugs in cerebrospinal fluid of advanced HIV-1-infected patients
    Andrea Antinori
    National Institute for Infectious Diseases Lazzaro Spallanzani, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    AIDS 16:1867-76. 2002

Detail Information

Publications120 found, 100 shown here

  1. pmc Long-term CD4+ T-cell count evolution after switching from regimens including HIV nucleoside reverse transcriptase inhibitors (NRTI) plus protease inhibitors to regimens containing NRTI plus non-NRTI or only NRTI
    Carlo Torti
    University of Brescia, Italy
    BMC Infect Dis 11:23. 2011
    ..Data regarding CD4+ recovery after switching from protease inhibitor (PI)-based regimens to regimens not containing PI are scarce...
  2. ncbi request reprint Cross-resistance among nonnucleoside reverse transcriptase inhibitors limits recycling efavirenz after nevirapine failure
    Andrea Antinori
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, 00149 Rome, Italy
    AIDS Res Hum Retroviruses 18:835-8. 2002
    ..No virological response was observed in six patients harboring a single Y181C/I mutation. On the basis of the present data, sequential use of NNRTIs should be avoided in the management of treatment failure...
  3. ncbi request reprint Better response to chemotherapy and prolonged survival in AIDS-related lymphomas responding to highly active antiretroviral therapy
    A Antinori
    National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy
    AIDS 15:1483-91. 2001
    ..To evaluate the impact of response to highly active antiretroviral therapy (HAART) on the natural history of AIDS non-Hodgkin's lymphoma (NHL) and to analyse the feasibility, efficacy and toxicity of HAART in combination with chemotherapy...
  4. ncbi request reprint Clinical epidemiology and survival of progressive multifocal leukoencephalopathy in the era of highly active antiretroviral therapy: data from the Italian Registry Investigative Neuro AIDS (IRINA)
    Andrea Antinori
    Clinical Department, Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, IRCCS, Roma, Italy
    J Neurovirol 9:47-53. 2003
    ..The use of cidofovir showed a trend towards a reduced risk of death...
  5. ncbi request reprint Relative prognostic value of self-reported adherence and plasma NNRTI/PI concentrations to predict virological rebound in patients initially responding to HAART
    Andrea Antinori
    Istituto Nazionale per le Malattie Infettive, L Spallanzani IRCCS, Roma, Italy
    Antivir Ther 9:291-6. 2004
    ..6%) experienced virological rebound by 96 weeks. Both self-reported non-adherence and sub-optimal concentration were independently associated with a higher risk of virological rebound...
  6. ncbi request reprint Antiviral efficacy and genotypic resistance patterns of combination therapy with stavudine/tenofovir in highly active antiretroviral therapy experienced patients
    Andrea Antinori
    National Institute for Infectious Diseases L Spallanzani IRCCS, Roma
    Antivir Ther 11:233-43. 2006
    ..To evaluate antiviral efficacy of stavudine/tenofovir (d4T/TDF) backbone combination in late-line antiretroviral therapy, and to assess clinical and virological determinants of treatment success...
  7. ncbi request reprint Virological response to salvage therapy in HIV-infected persons carrying the reverse transcriptase K65R mutation
    Andrea Antinori
    National Institute for Infectious Diseases L Spallanzani IRCCS, Roma, Italy
    Antivir Ther 12:1175-83. 2007
    ..The effect of the HIV reverse transcriptase K65R mutation on virological response to salvage therapy has not been clearly defined...
  8. ncbi request reprint Short Communication: Yersinia pseudotuberculosis septicemia in an HIV-infected patient failed HAART
    Andrea Antinori
    Dipartimento Clinico, INMI Lazzaro Spallanzani IRCCS, Rome, Italy
    AIDS Res Hum Retroviruses 20:709-10. 2004
    ..Specific amplicons for inv, yadA, and lcrF genes showed the pathogenetic potential of the Y. pseudotuberculosis serotype O1 isolate. A favorable clinical response to ceftriaxone and levofloxacin was observed...
  9. ncbi request reprint Prevalence, associated factors, and prognostic determinants of AIDS-related toxoplasmic encephalitis in the era of advanced highly active antiretroviral therapy
    Andrea Antinori
    Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    Clin Infect Dis 39:1681-91. 2004
    ..Characteristics, associated factors, and survival probability of toxoplasmic encephalitis (TE) in the era of advanced highly active antiretroviral therapy (HAART) have not been fully clarified...
  10. ncbi request reprint Factors influencing virological response to antiretroviral drugs in cerebrospinal fluid of advanced HIV-1-infected patients
    Andrea Antinori
    National Institute for Infectious Diseases Lazzaro Spallanzani, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    AIDS 16:1867-76. 2002
    ..To determine the effectiveness of antiretroviral therapy in controlling cerebrospinal fluid (CSF) HIV-1 replication and to assess factors related to virological response in advanced patients...
  11. ncbi request reprint Cardiomyopathy and encephalopathy in AIDS
    A Antinori
    National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy
    Ann N Y Acad Sci 946:121-9. 2001
    ..Antiretroviral therapy may reduce impact of neurologic and cardiac abnormalities by suppressing plasma HIV-1 viral load...
  12. ncbi request reprint Efficacy of cerebrospinal fluid (CSF)-penetrating antiretroviral drugs against HIV in the neurological compartment: different patterns of phenotypic resistance in CSF and plasma
    Andrea Antinori
    National Institute for Infectious Diseases, Lazzaro Spallanzani, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    Clin Infect Dis 41:1787-93. 2005
    ....
  13. doi request reprint Italian consensus statement on management of HIV-infected individuals with advanced disease naïve to antiretroviral therapy
    A Antinori
    Istituto Nazionale Malattie Infettive Lazzaro Spallanzani IRCCS, Via Portuense 292, 00149, Rome, Italy
    Infection 37:270-82. 2009
    ..Infection management in such patients can also be complicated by underlying conditions, comorbidities, and the need for concomitant medications...
  14. doi request reprint Effect of suppressing HIV viremia on the HIV progression of patients undergoing a genotype resistance test after treatment failure
    M Zaccarelli
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, Via Portuense 292, 00149, Rome, Italy
    Infection 37:203-9. 2009
    ..To assess the role of viral suppression on clinical progression following a genotypic resistance test (GRT), we have examined a database on patients failing to respond to combined antiretroviral therapy (cART)...
  15. ncbi request reprint Changing clinical presentation and survival in HIV-associated tuberculosis after highly active antiretroviral therapy
    E Girardi
    National Institute for Infectious Diseases L Spallanzani IRCCS, Rome, Italy
    J Acquir Immune Defic Syndr 26:326-31. 2001
    ..To assess changes in clinical presentation and outcome of HIV-associated tuberculosis (TB) before and after widespread implementation of highly active antiretroviral therapy (HAART)...
  16. ncbi request reprint Potent anti-retroviral therapy with or without cidofovir for AIDS-associated progressive multifocal leukoencephalopathy: extended follow-up of an observational study
    A De Luca
    Department of Clinical Infectious Diseases, Universita Cattolica del S Cuore, Rome, Italy
    J Neurovirol 7:364-8. 2001
    ..21, 95% confidence interval, 0.07-0.65; P = 0.005). A randomized study will definitively establish whether cidofovir confers significant advantage over HAART alone in AIDS-related PML...
  17. ncbi request reprint Changing disease patterns in focal brain lesion-causing disorders in AIDS
    A Ammassari
    Department of Infectious Diseases, Catholic University, Rome, Italy
    J Acquir Immune Defic Syndr Hum Retrovirol 18:365-71. 1998
    ..S. Centers for Disease Control and Prevention (CDC) criteria for presumptive diagnosis of toxoplasmic encephalitis (TE) for the years 1991 to 1996...
  18. doi request reprint Two different patterns of mutations are involved in the genotypic resistance score for atazanavir boosted versus unboosted by ritonavir in multiple failing patients
    M M Santoro
    Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy
    Infection 37:233-43. 2009
    ..To date, however, genotypic resistance scores (GRSs) have been developed only for boosted-ATV. We have determined GRS associated with virologic response (VR) for both ATV300/r and ATV400 in highly pre-treated HIV-1 infected patients...
  19. ncbi request reprint HIV infection among foreign transsexual sex workers in Rome: prevalence, behavior patterns, and seroconversion rates
    L Spizzichino
    Unita Operativa AIDS, Azienda Sanitaria Locale Roma E ASL RME, Rome, Italy
    Sex Transm Dis 28:405-11. 2001
    ..The Azienda Sanitaria Locale Roma E (ASL-RME) outpatient clinic is the main reference center in Rome for HIV testing of foreign people...
  20. ncbi request reprint Value of combined approach with thallium-201 single-photon emission computed tomography and Epstein-Barr virus DNA polymerase chain reaction in CSF for the diagnosis of AIDS-related primary CNS lymphoma
    A Antinori
    Department of Infectious Diseases, Catholic University, Rome, Italy
    J Clin Oncol 17:554-60. 1999
    ..To determine the diagnostic capability of thallium-201 (201Tl) single-photon emission computed tomography (SPECT) combined with Epstein-Barr virus DNA (EBV-DNA) in CSF for the diagnosis of AIDS-related primary CNS lymphoma (PCNSL)...
  21. ncbi request reprint Epidemiology and prognosis of AIDS-associated progressive multifocal leukoencephalopathy in the HAART era
    A Antinori
    National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy
    J Neurovirol 7:323-8. 2001
    ..7 log(10) JCV copies/ml (P at log rank = 0.01) in our experience. CSF JCV DNA load at 4 weeks of follow-up and clearance of JCV-DNA from CSF are associated with a better neurologic outcome and a longer survival...
  22. ncbi request reprint Female sex and the use of anti-allergic agents increase the risk of developing cutaneous rash associated with nevirapine therapy
    A Antinori
    National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy
    AIDS 15:1579-81. 2001
    ..Women receiving glucocorticoids had a 3 month cumulative probability of rash of 0.41...
  23. ncbi request reprint Minimally invasive diagnosis of acquired immunodeficiency syndrome-related primary central nervous system lymphoma
    A Cingolani
    Department of Infectious Diseases, Catholic University, Rome, Italy
    J Natl Cancer Inst 90:364-9. 1998
    ..We studied the clinical usefulness of testing CSF obtained by lumbar puncture for the presence of EBV-DNA as a minimally invasive approach to the diagnosis of AIDS-PCNSL in patients with focal brain lesions...
  24. ncbi request reprint Clinical and virological monitoring during treatment with intrathecal cytarabine in patients with AIDS-associated progressive multifocal leukoencephalopathy
    A De Luca
    Institute of Clinical Infectious Diseases, Catholic University, Rome, Italy
    Clin Infect Dis 28:624-8. 1999
    ..47 vs. 4.47 log10 copies/mL; P = .027). JC virus became undetectable in the only patient who had a long-term stable condition. The concentration of JC virus in CSF showed a correlation with clinical outcome...
  25. ncbi request reprint Changes in neurocognitive performance in a cohort of patients treated with HAART for 3 years
    V Tozzi
    Fourth Division of Infectious Diseases, I.R.C.C.S. Lazzaro Spallanzani, Rome, Italy
    J Acquir Immune Defic Syndr 28:19-27. 2001
    ....
  26. doi request reprint Effectiveness of antiretroviral regimens containing abacavir with tenofovir in treatment-experienced patients: predictors of virological response and drug resistance evolution in a multi-cohort study
    S Di Giambenedetto
    Institute of Clinical Infectious Diseases, Catholic University, Rome, Italy
    Infection 37:438-44. 2009
    ..We explored the efficacy of at least 16 weeks of ABC + TDF-containing cART regimens in 307 antiretroviral-experienced HIV-1-infected individuals included in observational databases...
  27. ncbi request reprint Circulating levels and ex vivo production of beta-chemokines, interferon gamma, and interleukin 2 in advanced human immunodeficiency virus type 1 infection: the effect of protease inhibitor therapy
    A De Luca
    Institute of Clinical Infectious Diseases, Catholic University, Rome, Italy
    AIDS Res Hum Retroviruses 16:835-43. 2000
    ..Residual late-stage IL-2 producers may represent a subset of patients with a higher potential for immunologic reconstitution...
  28. doi request reprint Self-reported sexual dysfunction is frequent among HIV-infected persons and is associated with suboptimal adherence to antiretrovirals
    Maria Paola Trotta
    Istituto Nazionale per le Malattie Infettive, L Spallanzani IRCCS, Rome, Italy
    AIDS Patient Care STDS 22:291-9. 2008
    ..44; 95% CI 1.30-9.08). In conclusion, patients' perceived SD represents a relevant problem for HIV-infected persons treated with antiretrovirals and is strongly associated with suboptimal HAART adherence...
  29. ncbi request reprint Incidence and determinants of bacterial infections in HIV-positive patients receiving anti-Pneumocystis carinii/Toxoplasma gondii primary prophylaxis within a randomized clinical trial
    R Murri
    Department of Infectious Diseases, Catholic University, Rome, Italy
    J Acquir Immune Defic Syndr 27:49-55. 2001
    ..82; p <.05 and HR, 10.15; p <.05, respectively). In conclusion, CTX at the dosage employed for primary PCP/TE prophylaxis does not seem to protect against bacterial infections more than second-line DP...
  30. doi request reprint Favourable evolution of virological and immunological profiles in treated and untreated patients in Italy in the period 1998-2008
    M C F Prosperi
    Clinic of Infectious Diseases, Catholic University of Sacred Heart, Rome, Italy
    HIV Med 12:174-82. 2011
    ....
  31. ncbi request reprint Evidence of dual sexual transmission of multi-resistant HIV with two years persistence of resistance to NRTI and NNRTI: a case report
    M Zaccarelli
    National Institute for Infectious Diseases Lazzaro Spallanzani, Via Portuense 292, 00149, Rome, Italy
    Infection 36:178-80. 2008
    ..Data also suggest that mutations related to NRTI and NNRTI resistance may persist for a long time in naive patients, over 2 years in the present case report...
  32. pmc Human equilibrative nucleoside transporter 1 and carcinoma of the ampulla of Vater: expression differences in tumour histotypes
    G Perrone
    Department of Anatomical Pathology, Campus Bio Medico University, Via Alvaro del Portillo 200, Rome, Italy
    Eur J Histochem 54:e38. 2010
    ....
  33. doi request reprint Incidence of malignancies in HIV-infected patients and prognostic role of current CD4 cell count: evidence from a large Italian cohort study
    M C F Prosperi
    Istituto di Clinica delle Malattie Infettive, Universita Cattolica del Sacro Cuore, Rome, Italy
    Clin Infect Dis 50:1316-21. 2010
    ..9-3.1 cases per 1000 person-years of follow-up), respectively. Lower current CD4 cell count was an independent predictor of developing malignancies, with the association being stronger for ADM than for NADM...
  34. ncbi request reprint [Guidelines for the management of HCV infection in HIV-infected patients. Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani]
    G Antonucci
    Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Istituto di Ricovero e Cura a Carattere Scientifico, Roma, Italy
    Infez Med 12:7-18. 2004
    ..The present guidelines cannot entirely substitute the judgement of an expert clinician. However, adherence to these guidelines will contribute to the improvement of the standard of care of HIV/HCV-co-infected persons...
  35. doi request reprint The lowest X4 Geno2Pheno false-positive rate is associated with greater CD4 depletion in HIV-1 infected patients
    M M Santoro
    University of Tor Vergata, Rome, Italy
    Clin Microbiol Infect 18:E289-98. 2012
    ....
  36. doi request reprint Rate of CD4+ cell count increase over periods of viral load suppression: relationship with the number of previous virological failures
    Maria Paola Trotta
    Clinical Department, National Institute for Infectious Diseases L Spallanzani, Roma, Italy
    Clin Infect Dis 51:456-64. 2010
    ..Although the kinetics of CD4(+) cell counts have been extensively studied in antiretroviral-naive HIV-infected patients, data on individuals who have failed combination antiretroviral therapy (cART) are lacking...
  37. ncbi request reprint AIDS-related focal brain lesions in the era of highly active antiretroviral therapy
    A Ammassari
    Department of Infectious Diseases, Catholic University, Rome, Italy
    Neurology 55:1194-200. 2000
    ..To compare the years since the introduction of highly active antiretroviral therapy (HAART) with the pre-HAART era for trends in the proportions of HIV-related focal brain lesion-causing disorders...
  38. ncbi request reprint Factors related to virologic failure among HIV-positive injecting drug users treated with combination antiretroviral therapy including two nucleoside reverse transcriptase inhibitors and nevirapine
    M Zaccarelli
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    AIDS Patient Care STDS 16:67-73. 2002
    ..Our results show that continuing injecting drug use and treatment breaks are the main factors that can lead to treatment failure in IDUs and easily to NNRTI class resistance...
  39. doi request reprint Promyelocytic leukemia (PML) gene expression is a prognostic factor in ampullary cancer patients
    B Vincenzi
    Department of Medical Oncology, University Campus Bio Medico, Rome, Italy
    Ann Oncol 20:78-83. 2009
    ..Promyelocytic leukemia (PML) tumor suppressor gene plays a key role in acute PML pathogenesis but its involvement in pathogenesis and prognosis of solid cancers has not been defined yet...
  40. doi request reprint Impact of antiretroviral dosing frequency and daily pill burden on virological success rates in patients of the ICoNA cohort starting their first ART
    A Ammassari
    National Institute for Infectious Diseases, Rome, Italy
    J Int AIDS Soc 15:18233. 2012
    ..85 [0.73-0.98]). Once-a-day dosing of ART, especially when combined with low daily pill burden, seems to be one of main factors contributing to the higher rate of success of ART in recent years...
  41. ncbi request reprint Neurocognitive impairment influences quality of life in HIV-infected patients receiving HAART
    V Tozzi
    Fourth Division of Infectious Diseases, National Institute for Infectious Diseases Lazzaro Spallanzani, Via Portuense 292, 00149 Rome, Italy
    Int J STD AIDS 15:254-9. 2004
    ..Neurocognitive impairment in patients receiving HAART was associated with reduced HRQoL. Identifying cognitive impairment may provide motivation for additional treatment to help patients to compensate for deficits in functioning...
  42. pmc COX-2 expression in ampullary carcinoma: correlation with angiogenesis process and clinicopathological variables
    G Perrone
    Surgical Pathology, Campus Bio Medico University, Rome, Italy
    J Clin Pathol 59:492-6. 2006
    ..Objective: To investigate by immunohistochemistry the expression of COX-2 and the angiogenesis process in a series of primary untreated ampullary carcinomas...
  43. ncbi request reprint Updated research nosology for HIV-associated neurocognitive disorders
    A Antinori
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, Instituto di Ricovero e Cura a Carattere Scientifico IRCCS, Rome, Italy
    Neurology 69:1789-99. 2007
    ..An algorithm is proposed to assist in standardized diagnostic classification of HAND...
  44. ncbi request reprint Self-reported symptoms and medication side effects influence adherence to highly active antiretroviral therapy in persons with HIV infection
    A Ammassari
    Clinica delle Malattie Infettive, Universita Cattolica del S Cuore, Roma, Italy
    J Acquir Immune Defic Syndr 28:445-9. 2001
    ..To identify variables predictive of nonadherence to highly active antiretroviral therapy (HAART) and to assess whether self-reported symptoms or medication side effects are related to adherence...
  45. doi request reprint Antiretroviral treatment-based cost saving interventions may offset expenses for new patients and earlier treatment start
    C Angeletti
    National Institute for Infectious Diseases L Spallanzani, Rome, Italy
    HIV Med 15:165-74. 2014
    ..The present study estimated the short/medium-term cost trends in response to the recent evolution of national guidelines and regional therapeutic protocols for cART in Italy...
  46. doi request reprint Timing of cART initiation after a first AIDS-defining event (ADE): temporal changes in clinical attitudes in a large cohort of HIV-infected patients
    A Cingolani
    Catholic University, Department of Infectious Diseases, Rome, Italy
    J Int AIDS Soc 15:18200. 2012
    ....
  47. ncbi request reprint Temporal change in the use of genotypic resistance testing over the years 1999--2003
    M Santoro
    Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy
    New Microbiol 27:141-4. 2004
    ..0001). Overall, data suggest that the genotype test is increasingly considered, and requested also for patients at earlier stages of drug history and/or at less severe disease stage...
  48. ncbi request reprint HHV-8/KSHV is not associated with AIDS-related primary central nervous system lymphoma
    A Antinori
    Department of Infectious Diseases, Catholic University, Roma, Italy
    Brain Pathol 9:199-208. 1999
    ..018), but not with the presence of AIDS-PCNSL. The results of our analysis conclusively assess that HHV-8/KSHV infection is not a feature of AIDS-PCNSL...
  49. pmc Changes in regular condom use among immigrant transsexuals attending a counselling and testing reference site in central Rome: a 12 year study
    M Zaccarelli
    National Institute for Infectious Diseases Lazzaro Spallanzani, Via Portuense 292, 00149 Rome, Italy
    Sex Transm Infect 80:541-5. 2004
    ..To analyse data from male to female transsexuals attending between 1992 and 2003 an outpatient clinic considered the main HIV counselling and testing site in Rome for foreign people...
  50. doi request reprint Genotypic testing on HIV-1 DNA as a tool to assess HIV-1 co-receptor usage in clinical practice: results from the DIVA study group
    V Svicher
    Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy
    Infection 42:61-71. 2014
    ....
  51. doi request reprint Drug-resistance development differs between HIV-1-infected patients failing first-line antiretroviral therapy containing nonnucleoside reverse transcriptase inhibitors with and without thymidine analogues
    M M Santoro
    University of Rome Tor Vergata, Rome, Italy
    HIV Med 14:571-7. 2013
    ....
  52. pmc No significant association between patient self-reported non-adherence to antiretrovirals and HIV-tropism: a preliminary analysis
    A Ammassari
    INMI L Spallanzani, IRCCS, Rome, Italy
    J Int AIDS Soc 15:18090. 2012
    ..It is possible that patient self-reported adherence is not able to capture nonadherence behaviors that underlie more pronounced viral replication which may be necessary for tropism switch...
  53. ncbi request reprint Cell death mechanisms in HIV-associated dementia: the involvement of syncytia
    R Nardacci
    National Institute for Infectious Diseases, Lazzaro Spallanzani, Via Portuense 292, 00149 Rome, Italy
    Cell Death Differ 12:855-8. 2005
  54. pmc Community-acquired Acinetobacter radioresistens bacteremia in an HIV-positive patient
    P Visca
    Dipartmento di Biologia, Universita di Roma, Rome, Italy
    Emerg Infect Dis 7:1032-5. 2001
    ..Bacterial identification was based on 16S rDNA sequence analysis. A. radioresistens can be considered as a cause of opportunistic infection in immunodeficient patients...
  55. doi request reprint Comparison of screening tools for the detection of neurocognitive impairment in HAART-treated patients
    A Antinori
    INMI L Spallanzani, Rome, Italy
    J Int AIDS Soc 15:18286. 2012
    ..Combining IHDS with one or two simple NP test may represent an improvement in the screening approach to the detection of both NCI and HAND...
  56. doi request reprint Prescription patterns and costs of antiretroviral therapy in HIV-infected naïve patients: theoretical impact of a regional therapeutic protocol
    A Ammassari
    INMI L Spallanzani IRCCS, Rome, Italy
    J Int AIDS Soc 15:18392. 2012
    ..Our findings highlight the need of standardized prescription strategies and that the introduction of PTR may allow a saving of up 10.4% of total cART expenses...
  57. ncbi request reprint T cell selection and differentiation in AIDS disease: the model of HIV-discordant monozygotic twins
    C Agrati
    National Institute for Infectious Diseases L Spallanzani, IRCCS, Rome, Italy
    J Biol Regul Homeost Agents 20:24-8. 2006
    ..Altogether, the model of HIV-discordant monozygotic twins is a valuable tool showing that HAART is not able to completely restore the CTL profile...
  58. doi request reprint Russell body gastritis associated with Helicobacter pylori infection in an HIV-positive patient: case report and review of the literature
    S Licci
    Department of Pathology, L Spallanzani, IRCCS, Rome, Italy
    Z Gastroenterol 47:357-60. 2009
    ..A review of all cases of RBG previously described in the English literature is reported in order to examine the clinical, endoscopic and microscopic features of this histopathological entity and the possible pathogenetic mechanisms...
  59. doi request reprint Late presentation of HIV infection: a consensus definition
    A Antinori
    National Institute for Infectious Diseases, Lazzaro Spallanzani, IRCCS, Rome, Italy
    HIV Med 12:61-4. 2011
    ..The objective of this article is to present a consensus definition of late presentation of HIV infection...
  60. ncbi request reprint Epidemiological and clinical aspects of mycoses in patients with AIDS-related pathologies
    G Morace
    Istituto di Microbiologia, , , Rome, Italy
    Eur J Epidemiol 6:398-403. 1990
    ..Biotyping of yeasts isolated between September 1988 and February 1989 with the killer system revealed type 377 to be the most common among the C. albicans isolates. It represented 70% of all the yeasts isolated...
  61. ncbi request reprint Plasma levels of interleukin-6 and interleukin-10 in preterm neonates evaluated for sepsis
    C Romagnoli
    Department of Neonatology, Catholic University Sacred Heart, Rome, Italy
    Eur J Pediatr 160:345-50. 2001
    ..IL-6 and IL-10 levels were significantly correlated with CRP levels on admission (r = 0.45; P = 0.05)...
  62. doi request reprint Haemolytic anaemia after oral artemether-lumefantrine treatment in a patient affected by severe imported falciparum malaria
    P De Nardo
    Lazzaro Spallanzani, National Institute for Infectious Diseases IRCCS, Via Portuense 292, 00179, Rome, Italy
    Infection 41:863-5. 2013
    ..To the best of our knowledge, this is the second reported case of a patient affected by severe falciparum malaria with haemolytic anaemia that is likely associated with oral artemether-lumefantrine treatment. ..
  63. pmc Adherence in HIV-positive patients treated with single-tablet regimens and multi-pill regimens: findings from the COMPACT study
    A Antinori
    National Institute for Infectious Diseases, Clinical Department, Rome, Italy
    J Int AIDS Soc 15:18098. 2012
    ..The use of an STR regimen appears an effective therapeutic option to avoid selective non-adherence and, consequently, to prevent virological failure and disease progression...
  64. pmc Nuclear and cytoplasmic expression of survivin in 67 surgically resected pancreatic cancer patients
    G Tonini
    Medical Oncology, University Campus Bio Medico, Rome, Via Emilio Longoni 83, 00155 Rome, Italy
    Br J Cancer 92:2225-32. 2005
    ..In particular, patients with high nuclear Survivin staining showed a longer survival, whereas patients with high cytoplasmic Survivin staining had a shorter overall survival...
  65. ncbi request reprint Meckel's diverticulum findings on Tc-99m red blood cell scintigraphy in a bleeding leukemic patient confirmed by Tc-99m pertechnetate scintigraphy
    L Ciccoritti
    Department of General Surgery, Catholic University of Rome, Rome, Italy
    Clin Nucl Med 32:668-70. 2007
    ..4 to 7.1 g/dL), despite 8 units of blood transfusion, emergency surgery was performed. Through a minilaparotomy a segmental small bowel resection, including Meckel diverticulum, was performed. The postoperative course was uneventful...
  66. ncbi request reprint Radiofrequency thermal ablation (RFA) of liver tumors: percutaneous and open surgical approaches
    A Crucitti
    Department of Surgery, Catholic University of the Sacred Heart, Rome, Italy
    J Exp Clin Cancer Res 22:191-5. 2003
    ..These results are encouraging in making the percutaneous approach of RFA the method of choice in these patients...
  67. ncbi request reprint Parallel conduction of the phase I preventive and therapeutic trials based on the Tat vaccine candidate
    S Bellino
    National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
    Rev Recent Clin Trials 4:195-204. 2009
    ..Further, the number of CD4 T cells correlated positively with anti-Tat antibody titers. Based on these results, a phase II study is ongoing in infected drug-treated individuals (http://www.hiv1tat-vaccines.info/)...
  68. ncbi request reprint AIDS-related Kaposi's Sarcoma: evaluation of potential new prognostic factors and assessment of the AIDS Clinical Trial Group Staging System in the Haart Era--the Italian Cooperative Group on AIDS and Tumors and the Italian Cohort of Patients Naive From A
    Guglielmo Nasti
    Division of Medical Oncology A, National Cancer Institute, Aviano PN, Italy
    J Clin Oncol 21:2876-82. 2003
    ..To assess potential new prognostic factors and to validate the AIDS Clinical Trials Group (ACTG) for AIDS-related Kaposi's sarcoma (AIDS-KS) staging system in the highly active antiretroviral therapy (HAART) era...
  69. ncbi request reprint Neurocognitive performance and quality of life in patients with HIV infection
    Valerio Tozzi
    4th Division of Infectious Diseases, I N M I Lazzaro Spallanzani, Via Portuense 292, 00149 Rome, Italy
    AIDS Res Hum Retroviruses 19:643-52. 2003
    ..Cognitive impairment in any cognitive domain explored in our battery is also associated with poor QoL. Poor performance on the Digit Symbol Test is the strongest predictor of poor QoL...
  70. ncbi request reprint HIV Type 1 replication in cerebrospinal fluid of patients with AIDS-related non-Hodgkin's lymphoma receiving chemotherapy and antiretroviral therapy
    Maria Letizia Giancola
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, Istituto di Ricovero e Cura a Carattere Scientifico, Via Portuense 292, 00149, Rome, Italy
    AIDS Res Hum Retroviruses 19:1091-5. 2003
    ....
  71. ncbi request reprint Discontinuation of maintenance therapy for cryptococcal meningitis in patients with AIDS treated with highly active antiretroviral therapy: an international observational study
    Cristina Mussini
    Clinic of Infectious and Tropical Diseases, University of Modena and Reggio Emilia, Azienda Policlinico, Modena, Italy
    Clin Infect Dis 38:565-71. 2004
    ..Recurrent cryptococcal infection should be suspected in patients whose serum cryptococcal antigen test results revert back to positive after discontinuation of maintenance therapy...
  72. doi request reprint Plasma HIV RNA decline and emergence of drug resistance mutations among patients with multiple virologic failures receiving resistance testing-guided HAART
    Valerio Tozzi
    National Institute for Infectious Diseases Lazzaro Spallanzani, 00149 Rome, Italy
    AIDS Res Hum Retroviruses 24:787-96. 2008
    ..In contrast, early changes in PVL levels were not. Virologic failure was associated with detection of emergent DRMs. Virologic rebound in patients on salvage-HAART should be addressed aggressively...
  73. ncbi request reprint Interpretation systems for genotypic drug resistance of HIV-1
    Andrea De Luca
    Istituto di Clinica delle Malattie Infettive, Universita Cattolica del Sacro Cuore, Rome, Italy
    Scand J Infect Dis Suppl 106:29-34. 2003
    ..Importantly, only 8 systems were intended for clinical use and 5 of these had at least partially undergone clinical validation...
  74. doi request reprint Cidofovir in addition to antiretroviral treatment is not effective for AIDS-associated progressive multifocal leukoencephalopathy: a multicohort analysis
    Andrea De Luca
    Institute of Clinical Infectious Diseases, Catholic University of Sacred Heart, Lazio Region, Rome, Italy
    AIDS 22:1759-67. 2008
    ..To establish the effectiveness of cidofovir for AIDS-related progressive multifocal leukoencephalopathy (PML) in patients concomitantly receiving combination antiretroviral therapy...
  75. doi request reprint Antiretroviral genotypic resistance in plasma RNA and whole blood DNA in HIV-1 infected patients failing HAART
    Annalisa Saracino
    Clinic of Infectious Diseases, University of Foggia, Foggia, Italy
    J Med Virol 80:1695-706. 2008
    ..Therefore, in some cases DNA plus RNA genotyping might assist in choosing more accurately subsequent antiretroviral regimens...
  76. ncbi request reprint HIV fitness and resistance as covariates associated with the appearance of mutations under antiretroviral treatment
    Carlo Federico Perno
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    Scand J Infect Dis Suppl 106:37-40. 2003
    ....
  77. doi request reprint Response to combination antiretroviral therapy: variation by age
    Caroline A Sabin
    AIDS 22:1463-73. 2008
    ..To provide information on responses to combination antiretroviral therapy in children, adolescents and older HIV-infected persons...
  78. ncbi request reprint Variable prediction of antiretroviral treatment outcome by different systems for interpreting genotypic human immunodeficiency virus type 1 drug resistance
    Andrea De Luca
    Institute of Clinical Infectious Diseases, Catholic University, Rome, Italy
    J Infect Dis 187:1934-43. 2003
    ..GSSs predicted changes in HIV RNA levels better in adherent patients than in nonadherent individuals. Interpretation may be improved, and knowledge should be used uniformly throughout different expert systems...
  79. ncbi request reprint Using a database of HIV patients undergoing genotypic resistance test after HAART failure to understand the dynamics of M184V mutation
    Mauro Zaccarelli
    National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy
    Antivir Ther 8:51-6. 2003
    ..M184V/I mutation is associated with high-level phenotypic resistance to lamivudine (3TC). The aim of the present analysis was to correlate the time of appearance/disappearance of M184V/I with duration of 3TC treatment...
  80. ncbi request reprint Usefulness of monitoring HIV drug resistance and adherence in individuals failing highly active antiretroviral therapy: a randomized study (ARGENTA)
    Antonella Cingolani
    Istituto di Clinica delle Malattie Infettive, Universita Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, 00168 Rome, Italy
    AIDS 16:369-79. 2002
    ....
  81. ncbi request reprint Reduction of HIV-1 viral load in saliva by indinavir-containing antiretroviral regimen
    Giuseppina Liuzzi
    AIDS 16:503-4. 2002
  82. ncbi request reprint Highly active antiretroviral therapy and allogeneic CD34(+) peripheral blood progenitor cells transplantation in an HIV/HCV coinfected patient with acute myeloid leukemia
    Federica Sora
    Istituto di Ematologia, Universita Cattolica Sacro Cuore, Rome, Italy
    Exp Hematol 30:279-84. 2002
    ..To evaluate the safety, feasibility, and efficacy of allogeneic stem cell transplantation (SCT) for acute myelogenous leukemia (AML) in a young female coinfected by HIV and HCV undergoing highly active antiretroviral therapy (HAART)...
  83. ncbi request reprint Kinetics of CD4 cells after discontinuation of antiretroviral therapy in patients with virological failure and a CD4 cell count greater than 500 cells/microl
    Cristina Mussini
    Clinic of Infectious and Tropical Diseases, University of Modena and Reggio Emilia, Modena, Italy
    AIDS 16:1551-4. 2002
    ..This decline was unrelated to the CD4 cell count and HIV-RNA values at interruption, but was more profound in patients in whom the M184V mutation had disappeared after lamivudine discontinuation...
  84. ncbi request reprint A genotypic drug resistance interpretation algorithm that significantly predicts therapy response in HIV-1-infected patients
    Kristel Van Laethem
    Rega Institute for Medical Research and University Hospitals, Katholieke Universiteit Leuven, Belgium
    Antivir Ther 7:123-9. 2002
    ..The development of a genotypic drug resistance interpretation algorithm, and the evaluation of its power to predict therapy outcome...
  85. ncbi request reprint Coinfection with hepatitis viruses and outcome of initial antiretroviral regimens in previously naive HIV-infected subjects
    Andrea De Luca
    Institute of Clinical Infectious Diseases, Catholic University of the Sacred Heart, Rome, Italy
    Arch Intern Med 162:2125-32. 2002
    ..The effect of chronic coinfection with hepatitis viruses on the response to therapy against human immunodeficiency virus 1 (HIV-1) remains debated...
  86. ncbi request reprint Incidence of adipose tissue alterations in first-line antiretroviral therapy: the LipoICoNa Study
    Massimo Galli
    Institute of Infectious Diseases and Tropical Medicine, University of Milan, L Sacco Hospital, Via G B Grassi, 74 20157 Milan, Italy
    Arch Intern Med 162:2621-8. 2002
    ..Adipose tissue alterations (ATAs) are a frequent untoward effect of antiretroviral therapy, the causes of which remain incompletely explained...
  87. ncbi request reprint Underevaluation of HIV-1 plasma viral load by a commercially available assay in a cluster of patients infected with HIV-1 A/G circulating recombinant form (CRF02)
    Alessandra Amendola
    Laboratory of Virology, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Via Portuense 292, 00149 Rome, Italy
    J Acquir Immune Defic Syndr 31:488-94. 2002
    ..These results are potentially important as global distribution of new HIV-1 subtypes is expanding, and recombinant strains, particularly CRF02, are emerging and becoming highly prevalent...
  88. ncbi request reprint Virologic correlates of adherence to antiretroviral medications and therapeutic failure
    Carlo Federico Perno
    INMI L Spallanzani, Rome, Italy
    J Acquir Immune Defic Syndr 31:S118-22. 2002
    ....
  89. ncbi request reprint Morphologic alterations in HIV-infected people with lipodystrophy are associated with good adherence to HAART
    Giovanni Guaraldi
    Department of Medical and Surgery Specialities, Infectious Diseases Clinic, University of Modena and Reggio Emilia School of Medicine, Italy
    HIV Clin Trials 4:99-106. 2003
    ..To evaluate the association between adherence to drugs and morphologic alterations (MOA) in a cohort of HIV-infected patients on HAART...
  90. ncbi request reprint Adherence to highly active antiretroviral therapy is better in patients receiving non-nucleoside reverse transcriptase inhibitor-containing regimens than in those receiving protease inhibitor-containing regimens
    Maria Paola Trotta
    Istituto Nazionale per le Malattie Infettive, L Spallanzani IRCCS, Rome, Italy
    AIDS 17:1099-102. 2003
    ..By contrast, younger age, self-report of active drug use, fatigue or vomiting negatively affected adherence. Self-reported sexual dysfunction was significantly associated with non-adherence only in PI-treated individuals...
  91. ncbi request reprint Clinical implications of HIV-1 drug resistance in the neurological compartment
    Andrea Antinori
    National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy
    Scand J Infect Dis Suppl 106:41-4. 2003
    ....
  92. doi request reprint Specific enfuvirtide-associated mutational pathways in HIV-1 Gp41 are significantly correlated with an increase in CD4(+) cell count, despite virological failure
    Valentina Svicher
    Department of Experimental Medicine, University of Tor Vergata Rome, Italy
    J Infect Dis 197:1408-18. 2008
    ..We investigated the correlation of enfuvirtide (ENF)-associated gp41 mutational clusters with viroimmunological parameters, as well as the potential underlying mechanisms...
  93. ncbi request reprint Specific mutations in HIV-1 gp41 are associated with immunological success in HIV-1-infected patients receiving enfuvirtide treatment
    Stefano Aquaro
    Department of Experimental Medicine and Biochemical Sciences, University of Rome, Tor Vergata, Rome, Italy
    J Antimicrob Chemother 58:714-22. 2006
    ..To investigate gp41 variability and correlation with viro-immunological parameters in 54 HIV-1-infected patients receiving enfuvirtide added as single active drug to a failing regimen...
  94. ncbi request reprint Temporal characterization of drug resistance associated mutations in HIV-1 protease and reverse transcriptase in patients failing antiretroviral therapy
    Maria Mercedes Santoro
    Department of Experimental Medicine, Tor Vergata University of Rome, Italy
    New Microbiol 29:89-100. 2006
    ....
  95. ncbi request reprint Highly active antiretroviral therapy reduces the age-associated risk of dementia in a cohort of older HIV-1-infected patients
    Dora Larussa
    Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, IRCCS, Rome, Italy
    AIDS Res Hum Retroviruses 22:386-92. 2006
    ..These results may have significant implications for the clinical management of the older HIV population...
  96. ncbi request reprint Construction, training and clinical validation of an interpretation system for genotypic HIV-1 drug resistance based on fuzzy rules revised by virological outcomes
    Andrea De Luca
    Institute of Clinical Infectious Diseases, Catholic University, Rome, Italy
    Antivir Ther 9:583-93. 2004
    ....
  97. ncbi request reprint Clinical and genotypic correlates of mutation K65R in HIV-infected patients failing regimens not including tenofovir
    Maria Paola Trotta
    Clinical Department, National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy
    J Med Virol 78:535-41. 2006
    ..However, exposure to abacavir and/or efavirenz, presence of Q151M and/or L100I, and prior AIDS may favor the selection of this mutation. Conversely, long 3TC exposure, and the presence of M184V or NAMs seem to be protective...
  98. ncbi request reprint Selection of antiretroviral therapy guided by genotypic or phenotypic resistance testing: an open-label, randomized, multicenter study (PhenGen)
    Annalisa Saracino
    Clinic of Infectious Diseases, University of Foggia, Foggia, Italy
    J Acquir Immune Defic Syndr 37:1587-98. 2004
    ..55; P = 0.001), and adherence to expert advice (OR = 0.37; P < 0.001) predicted virologic response. The vPt is as predictive of treatment outcome as the rPT. Use of expert advice significantly improved the response to therapy...
  99. ncbi request reprint CD4 cell-monitored treatment interruption in patients with a CD4 cell count > 500 x 106 cells/l
    Cristina Mussini
    Clinic of Infectious and Tropical Diseases, Azienda Ospedaliero Universitaria Policlinico, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41100 Modena, Italy
    AIDS 19:287-94. 2005
    ..Little is known about CD4 cell count changes in patients with high CD4 cell counts who interrupt antiretroviral therapy, especially in those with a nadir of 250-350 x 10 cells/l...
  100. ncbi request reprint Cerebrospinal fluid HIV-1 infection usually responds well to antiretroviral treatment
    Asa Mellgren
    Department of Infectious Diseases, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Antivir Ther 10:701-7. 2005
    ..We conclude that the central nervous system (CNS) is usually not a 'sanctuary site', difficult to reach with combination antiretroviral treatment...
  101. ncbi request reprint Neurocognitive impairment and survival in a cohort of HIV-infected patients treated with HAART
    Valerio Tozzi
    National Institute for Infectious Diseases Lazzaro Spallanzani, 00149 Rome, Italy
    AIDS Res Hum Retroviruses 21:706-13. 2005
    ....