Adriana Albini

Summary

Affiliation: National Cancer Research Institute
Country: Italy

Publications

  1. ncbi Tumor inflammatory angiogenesis and its chemoprevention
    Adriana Albini
    National Institute for Research on Cancer IST, Genoa, Italy
    Cancer Res 65:10637-41. 2005
  2. ncbi The "chemoinvasion assay": a tool to study tumor and endothelial cell invasion of basement membranes
    Adriana Albini
    National Cancer Research Institute, 16132 Genova, Italy
    Int J Dev Biol 48:563-71. 2004
  3. ncbi Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets
    Adriana Albini
    Molecular Oncology Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    FASEB J 20:527-9. 2006
  4. doi Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-kappaB and p53 modulation
    Stefano Monteghirfo
    Oncologia Molecolare, Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi, 10, 16132 Genova, Italy
    Mol Cancer Ther 7:2692-702. 2008
  5. ncbi Mechanisms of inhibition of tumor angiogenesis and vascular tumor growth by epigallocatechin-3-gallate
    Gianfranco Fassina
    Tumor Progression Unit and Molecular Oncology Lab, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Clin Cancer Res 10:4865-73. 2004
  6. ncbi Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate
    Raffaella Dell'eva
    Molecular Oncology, National Cancer Research Institute IST, Largo Rosanna Benzi 10, 16132 Genova, Italy
    Biochem Pharmacol 68:2359-66. 2004
  7. ncbi Molecular mechanisms of action of angiopreventive anti-oxidants on endothelial cells: microarray gene expression analyses
    Ulrich Pfeffer
    Functional Genomics Unit, National Cancer Research Institute, Genova, Italy
    Mutat Res 591:198-211. 2005
  8. ncbi Inhibition of tumor angiogenesis by angiostatin: from recombinant protein to gene therapy
    Raffaella Dell'eva
    Laboratory of Molecular Biology, National Cancer Research Institute, Genoa, Italy
    Endothelium 9:3-10. 2002
  9. ncbi Alpha-lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis
    Monica Morini
    Molecular Oncology Laboratory, National Cancer Research Institute, Genoa, Italy
    J Neuroimmunol 148:146-53. 2004
  10. doi Metabolic regulation and redox activity as mechanisms for angioprevention by dietary phytochemicals
    Francesca Tosetti
    Department of Translational Oncology, Istituto Nazionale per la Ricerca sul Cancro IST, Genoa, Italy
    Int J Cancer 125:1997-2003. 2009

Collaborators

Detail Information

Publications69

  1. ncbi Tumor inflammatory angiogenesis and its chemoprevention
    Adriana Albini
    National Institute for Research on Cancer IST, Genoa, Italy
    Cancer Res 65:10637-41. 2005
    ..We propose chemoprevention of inflammatory angiogenesis as a way of checking the cancer before it progresses...
  2. ncbi The "chemoinvasion assay": a tool to study tumor and endothelial cell invasion of basement membranes
    Adriana Albini
    National Cancer Research Institute, 16132 Genova, Italy
    Int J Dev Biol 48:563-71. 2004
    ..We will describe the assay and review some of the major results it enabled to obtain...
  3. ncbi Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets
    Adriana Albini
    Molecular Oncology Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    FASEB J 20:527-9. 2006
    ..Our results suggest that XN can be added to the expanding list of antiangiogenic chemopreventive drugs whose potential in cancer prevention and therapy should be evaluated...
  4. doi Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-kappaB and p53 modulation
    Stefano Monteghirfo
    Oncologia Molecolare, Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi, 10, 16132 Genova, Italy
    Mol Cancer Ther 7:2692-702. 2008
    ....
  5. ncbi Mechanisms of inhibition of tumor angiogenesis and vascular tumor growth by epigallocatechin-3-gallate
    Gianfranco Fassina
    Tumor Progression Unit and Molecular Oncology Lab, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Clin Cancer Res 10:4865-73. 2004
    ..Here, we examined the effects of this compound on the two key cell populations typically involved in tumor growth: tumor cells and endothelial cells...
  6. ncbi Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate
    Raffaella Dell'eva
    Molecular Oncology, National Cancer Research Institute IST, Largo Rosanna Benzi 10, 16132 Genova, Italy
    Biochem Pharmacol 68:2359-66. 2004
    ..As a low-cost drug, it might be of particular interest for areas of Kaposi's sarcoma endemics. ART could be useful for the prevention of tumor angiogenesis...
  7. ncbi Molecular mechanisms of action of angiopreventive anti-oxidants on endothelial cells: microarray gene expression analyses
    Ulrich Pfeffer
    Functional Genomics Unit, National Cancer Research Institute, Genova, Italy
    Mutat Res 591:198-211. 2005
    ..Down-regulation of the TNFalpha responsive pro-metastatic, pro-inflammatory genes, urokinase plasminogen activator and selectin E, further implies anti-metastatic effects for these drugs...
  8. ncbi Inhibition of tumor angiogenesis by angiostatin: from recombinant protein to gene therapy
    Raffaella Dell'eva
    Laboratory of Molecular Biology, National Cancer Research Institute, Genoa, Italy
    Endothelium 9:3-10. 2002
    ..In this review we compare the different gene therapy strategies that have been applied to angiostatin, with special regard to their ability to provide sufficient angiostatin at the target site...
  9. ncbi Alpha-lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis
    Monica Morini
    Molecular Oncology Laboratory, National Cancer Research Institute, Genoa, Italy
    J Neuroimmunol 148:146-53. 2004
    ....
  10. doi Metabolic regulation and redox activity as mechanisms for angioprevention by dietary phytochemicals
    Francesca Tosetti
    Department of Translational Oncology, Istituto Nazionale per la Ricerca sul Cancro IST, Genoa, Italy
    Int J Cancer 125:1997-2003. 2009
    ..These concepts provide a broader framework for pharmacological application of phytochemical-derived drugs against cancer...
  11. ncbi The angiogenic switch in solid tumors: clinical implications
    Francesca Tosetti
    Laboratory of Molecular Biology, National Cancer Research Institute, Genoa, Italy
    Suppl Tumori 1:S9-11. 2002
  12. ncbi Tumors and inflammatory infiltrates: friends or foes?
    Claudio Brigati
    Molecular Biology Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Clin Exp Metastasis 19:247-58. 2002
    ..Lancet 2001; 357: 539-45), by focussing more specifically to the relation between inflammation and tumor invasion and how this could drive rational therapeutic approaches...
  13. ncbi Neutrophils and angiogenesis: potential initiators of the angiogenic cascade
    Roberto Benelli
    Istituto Nazionale per la Ricera sul Cancro, Genoa, Italy
    Chem Immunol Allergy 83:167-81. 2003
  14. ncbi Neutrophils as a key cellular target for angiostatin: implications for regulation of angiogenesis and inflammation
    Roberto Benelli
    Centro di Biotecnologie Avanzate, 16132 Genova, Italy
    FASEB J 16:267-9. 2002
    ..These data show that angiostatin directly inhibits neutrophil migration and neutrophil-mediated angiogenesis and indicate that angiostatin might inhibit inflammation...
  15. pmc Prediction of breast cancer metastasis by genomic profiling: where do we stand?
    Ulrich Pfeffer
    Functional Genomics, National Cancer Research Institute, Genoa, Italy
    Clin Exp Metastasis 26:547-58. 2009
    ..Already today, signatures are, however, useful for clinical decisions in specific cases, in particular if the personal inclination of the patient towards different treatment strategies is taken into account...
  16. ncbi Allele-specific patterns of the mouse parathyroid hormone-related protein: influences on cell adhesion and migration
    Roberto Benelli
    Molecular Biology Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Oncogene 22:7711-5. 2003
    ..These findings suggest that the cancer modifier effects of the mouse Pthlh gene are mediated by differential cell adhesion and migration effects of PTHrP variants...
  17. ncbi Marine sponge-derived polymeric alkylpyridinium salts as a novel tumor chemotherapeutic targeting the cholinergic system in lung tumors
    Laura Paleari
    Laboratory of Molecular Oncology, Department of Translational Oncology, National Institute for Cancer Research IST, 16132 Genova, Italy
    Int J Oncol 29:1381-8. 2006
    ....
  18. ncbi Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent
    Gianfranco Fassina
    Instituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    AIDS 16:939-41. 2002
    ..EGCG strongly inhibited the replication of both virus strains as determined by reverse transcriptase and p24 assays on the cell supernatants...
  19. ncbi HIV Tat, its TARgets and the control of viral gene expression
    Claudio Brigati
    Molecular Oncology Laboratory, National Cancer Research Institute, c o Centro di Biotecnologie Avanzante, Largo Rosanna Benzi 10, 16132 Genova, Italy
    FEMS Microbiol Lett 220:57-65. 2003
    ..Finally, extracellular Tat can be internalized by cells through an active endocytosis process. Here we discuss some of the molecular mechanisms involved in intracellular and extracellular Tat function...
  20. ncbi Kaposi's sarcoma and human chorionic gonadotropin: mechanisms, moieties and mysteries
    Davide Bisacchi
    Laboratory of Molecular Biology, National Cancer Research Institute, Genova, Italy
    Biol Chem 383:1315-20. 2002
    ..While the discrepancy between laboratory tests and clinical trials remains a mystery, little is known about potential anti-KS mechanisms of the hormone itself and/or other active moieties present in u-hCG...
  21. ncbi N-i-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP
    Armando Rossello
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Pisa, Via Bonanno, 6, 56126 Pisa, Italy
    Bioorg Med Chem Lett 15:1321-6. 2005
    ..The simultaneous inhibition of these two enzymes yields type C compounds, which are potent antiangiogenic agents, able to block a chemoinvasion model on HUVEC cells in the micromolar range...
  22. ncbi Biological assays and genomic analysis reveal lipoic acid modulation of endothelial cell behavior and gene expression
    Patrizia Larghero
    Centro di Biotecnologie Avanzate, Genova, Italy
    Carcinogenesis 28:1008-20. 2007
    ..According to our data, LA has promising anti-angiogenic properties, though its influence on central metabolic pathways should suggest more caution about its widespread and not prescribed use at pharmacological doses...
  23. ncbi The transforming growth factor-beta family members bone morphogenetic protein-2 and macrophage inhibitory cytokine-1 as mediators of the antiangiogenic activity of N-(4-hydroxyphenyl)retinamide
    Nicoletta Ferrari
    Molecular Oncology Laboratory, National Institute for Cancer Research, Genova, Italy
    Clin Cancer Res 11:4610-9. 2005
    ..N-(4-hydroxyphenyl)retinamide (fenretinide; 4HPR) has been found to inhibit and/or prevent tumor growth under diverse conditions. Although 4HPR is antiangiogenic, the molecular mechanisms of this effect remain largely unknown...
  24. ncbi Antiangiogenic activity of the MDM2 antagonist nutlin-3
    Paola Secchiero
    Department of Morphology and Embryology, Human Anatomy Section, University of Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Circ Res 100:61-9. 2007
    ....
  25. ncbi Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells
    Roberto Bianco
    Cattedra di Oncologia Medica, Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Universita di Napoli Federico II, Via S Pansini 5, Naples, Italy
    Clin Cancer Res 14:5069-80. 2008
    ..Combined inhibition of EGFR and other signaling proteins has become a successful therapeutic approach, stimulating the search for further determinants of resistance as basis for novel therapeutic strategies...
  26. doi Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268
    Karen Liby
    Department of Pharmacology, Dartmouth Medical School, Hanover, NH 03755, USA
    Clin Cancer Res 14:4556-63. 2008
    ....
  27. ncbi Inflammation, inflammatory cells and angiogenesis: decisions and indecisions
    Douglas M Noonan
    Department of Clinical and Biological Sciences, Universita degli Studi dell Insubria, Via Ottorino Rossi 9, 21100, Varese, Italy
    Cancer Metastasis Rev 27:31-40. 2008
    ..Thus the immune system itself represents a major pharmaceutical target and links angiogenesis inhibition to immunotherapy...
  28. ncbi The synthetic oleanane triterpenoid, CDDO-methyl ester, is a potent antiangiogenic agent
    Nicola Vannini
    Multimedica IRCCS, Milan, Italy
    Mol Cancer Ther 6:3139-46. 2007
    ....
  29. ncbi Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis
    Raffaele Niero
    Department of Experimental Biomedical Sciences, Medical School, Padova, Italy
    J Pharmacol Exp Ther 321:492-500. 2007
    ..These results indicate that Hyp is a powerful anti-inflammatory compound with therapeutic potential, and they elucidate mechanistic keys...
  30. ncbi Tumor microenvironment, a dangerous society leading to cancer metastasis. From mechanisms to therapy and prevention
    Adriana Albini
    IRCCS Multimedica Milano, Milan, Italy
    Cancer Metastasis Rev 27:3-4. 2008
    ....
  31. ncbi AKT/NF-kappaB inhibitor xanthohumol targets cell growth and angiogenesis in hematologic malignancies
    Claudia Ambrosini
    Molecular Oncology, National Institute for Cancer Research, Genova, Italy
    Cancer 110:2007-11. 2007
    ..Leukemias are dependent on Akt/NF-kappaB activation and angiogenesis...
  32. ncbi Molecular pathways for cancer angioprevention
    Adriana Albini
    IRCCS Multimedica, Milan, Italy
    Clin Cancer Res 13:4320-5. 2007
    ..We highlight diverse mechanisms of action, implying that combination angioprevention approaches could further improve efficacy and be transferred to clinical practice...
  33. ncbi The chemoinvasion assay: a method to assess tumor and endothelial cell invasion and its modulation
    Adriana Albini
    Polo Scientifico e Tecnologico, IRCCS Multimedica, Milano, Italy
    Nat Protoc 2:504-11. 2007
    ..This protocol can be completed in 9 h...
  34. ncbi Angiogenesis and cancer prevention: a vision
    Douglas M Noonan
    Dipartimento di Scienze Biologiche e Cliniche, Universita dell Insubria, Varese, Italy
    Recent Results Cancer Res 174:219-24. 2007
    ....
  35. ncbi The urokinase-type plasminogen activator, its receptor and u-PA inhibitor type-1 affect in vitro growth and invasion of Kaposi's sarcoma and capillary endothelial cells: role of HIV-Tat protein
    Francesca Margheri
    Department of Experimental Pathology and Oncology, University of Florence, Italy
    Int J Oncol 27:223-35. 2005
    ..These observations suggest the potential for application of u-PA/u-PAR system inhibitors for control of AIDS-associated KS, that has a high risk of recurrence with highly active antiretroviral therapy failure, and of other KS forms...
  36. ncbi Proteinase-3 directly activates MMP-2 and degrades gelatin and Matrigel; differential inhibition by (-)epigallocatechin-3-gallate
    Elga Pezzato
    Department of Experimental Biomedical Sciences, Medical School, Padova, Italy
    J Leukoc Biol 74:88-94. 2003
    ..These results add new activities to the list of those exerted by PR-3 and indicate a differential inhibition as a result of EGCG...
  37. ncbi AAV-mediated gene transfer of tissue inhibitor of metalloproteinases-1 inhibits vascular tumor growth and angiogenesis in vivo
    Serena Zacchigna
    Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    Cancer Gene Ther 11:73-80. 2004
    ..These results indicate that transfer and overexpression of the Timp1 gene is a promising therapeutic strategy to target tumor-associated angiogenesis in cancer gene therapy...
  38. ncbi Role of the alpha3beta1 and alpha6beta4 integrins in tumor invasion
    Gianluigi Giannelli
    Department of Internal Medicine, Immunology, and Infectious Diseases, University of Bari Medical School, Italy
    Clin Exp Metastasis 19:217-23. 2002
    ..In this Review, we will focus on the role of these two receptors and the mechanisms by which they influence the invasion process...
  39. ncbi Inhibition of Kaposi's sarcoma in vivo by fenretinide
    Nicoletta Ferrari
    Molecular Oncology Laboratory, the National Institute for Cancer Research, Genova, Italy
    Clin Cancer Res 9:6020-9. 2003
    ..We examined the effects of fenretinide [N-(4-hydroxyphenyl)retinamide; (4HPR)] on highly angiogenic Kaposi's sarcoma tumors in vivo and investigated the mechanisms involved for potential clinical applications...
  40. ncbi Neutrophil restraint by green tea: inhibition of inflammation, associated angiogenesis, and pulmonary fibrosis
    Massimo Dona
    Department of Experimental Biomedical Sciences, Medical School of Padova, Padova, Italy
    J Immunol 170:4335-41. 2003
    ..These results provide molecular and cellular insights into the claimed beneficial properties of green tea and indicate that EGCG is a potent anti-inflammatory compound with therapeutic potential...
  41. ncbi Prostate carcinoma and green tea: (-)epigallocatechin-3-gallate inhibits inflammation-triggered MMP-2 activation and invasion in murine TRAMP model
    Luigi Sartor
    Department of Experimental Biomedical Sciences, Medical School, Padova, Italy
    Int J Cancer 112:823-9. 2004
    ..These results suggest that inflammatory involvement of prostate carcinoma could be efficaciously prevented by green tea with a concomitant lowering of the invasive potential...
  42. ncbi Angioprevention': angiogenesis is a common and key target for cancer chemopreventive agents
    Francesca Tosetti
    Molecular Biology Laboratory, National Cancer Research Institute IST, Genova, Italy
    FASEB J 16:2-14. 2002
    ..We analyze the mechanisms on how and why chemopreventive agents could exert antiangiogenic effects aimed at controlling tumor growth, and their potential use in the clinic...
  43. ncbi Angiostatin inhibits extracellular HIV-Tat-induced inflammatory angiogenesis
    Roberto Benelli
    Molecular Biology Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Int J Oncol 22:87-91. 2003
    ..As these cell types are also the targets of extracellularly released Tat, angiostatin could be used to contrast Tat-associated vasculopathies...
  44. ncbi Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS
    Debora Giunti
    Neuroimmunology Unit, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy
    J Leukoc Biol 73:584-90. 2003
    ..These cells are recruited into the CSF by inducible chemokines. Thus, CSF represents a transitional station for T cells trafficking to and from the NS...
  45. ncbi Inhibition of a vascular ocular tumor growth by IL-12 gene transfer
    Adriana Albini
    Istituto di Ricovero e Cura a Carattere Scientifico MultiMedica, Via Fantoli Gaudenzio, 16 15, Milano 20138, Italy
    Clin Exp Metastasis 24:485-93. 2007
    ..Taken together, our data suggest that IL-12 gene transfer can provide anti-angiogenic effects without toxicity and may be particularly suited for therapy of vascularized ocular tumors...
  46. ncbi Re: Microarray studies challenge theories of metastasis
    Ulrich Pfeffer
    J Natl Cancer Inst 95:829. 2003
  47. ncbi N-(4-hydroxyphenyl)retinamide inhibits retinoblastoma growth through reactive oxygen species-mediated cell death
    Francesca Tosetti
    Molecular Oncology Laboratory, Genova, Italy
    Mol Pharmacol 63:565-73. 2003
    ..These findings could have an important translational value for chemoprevention or early intervention in the treatment of retinoblastoma...
  48. ncbi Human chorionic gonadotropin inhibits Kaposi's sarcoma associated angiogenesis, matrix metalloprotease activity, and tumor growth
    Ulrich Pfeffer
    Laboratory of Molecular Biology, National Cancer Research Institute Genova, c o Advanced Biotechnology Center Genova, Large Rosanna Benzi 10, Genoa 16132, Italy
    Endocrinology 143:3114-21. 2002
    ....
  49. ncbi Endothelial cell aging and apoptosis in prevention and disease: E-selectin expression and modulation as a model
    Nicola Vannini
    Department of Clinical and Biological Sciences, Universita degli Studi dell Insubria, School of Medicine, Varese, Italy
    Curr Pharm Des 14:221-5. 2008
    ..These data underscore the effects of a chemoprevention agent in modulating parameters associated with endothelial cell aging...
  50. ncbi Generation of biologically active angiostatin kringle 1-3 by activated human neutrophils
    Patrizia Scapini
    Section of General Pathology, Department of Pathology, University of Verona, Verona, Italy
    J Immunol 168:5798-804. 2002
    ....
  51. ncbi 28th meeting of the Italian Cancer Society (SIC). New challenges of molecular oncology
    Pier Luigi Lollini
    Tumori 88:77-81. 2002
  52. ncbi Oxytocin is a growth factor for Kaposi's sarcoma cells: evidence of endocrine-immunological cross-talk
    Paola Cassoni
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    Cancer Res 62:2406-13. 2002
    ....
  53. ncbi Anti-invasive effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), a natural inhibitor of metallo and serine proteases
    Roberto Benelli
    Centro di Biotecnologie Avanzate, Genova, Italy
    Biol Chem 383:101-5. 2002
    ..In this brief review we focus on the inhibitory activity of catechins derived from green tea toward proteases involved in tumor invasion...
  54. ncbi The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice
    Beatrice Bachmeier
    Department of Clinical Chemistry and Clinical Biochemistry, Surgical Hospital, Ludwig Maximilians University Munich, Germany
    Cell Physiol Biochem 19:137-52. 2007
    ..Dietary chemoprevention of metastases appears therefore feasible...
  55. ncbi Induction of apoptosis by fenretinide in tumor cell lines correlates with DLX2, DLX3 and DLX4 gene expression
    Nicoletta Ferrari
    Istituto Nazionale per la Ricerca sul Cancro IST, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Oncol Rep 10:973-7. 2003
    ..Our data support the notion that DLX2, 3, 4 genes could participate in the control of 4HPR-mediated apoptosis, making them important molecules for the monitoring of therapy efficacy in cancer patients...
  56. ncbi Transcriptional control of cell density dependent regulation of matrix metalloproteinase and TIMP expression in breast cancer cell lines
    Beatrice E Bachmeier
    Dept of Clinical Chemistry and Clinical Biochemistry, Surgical Hospital, Ludwig Maximilians University, Nussbaumstr 20, D 80336 MUnchen, Germany
    Thromb Haemost 93:761-9. 2005
    ..Overexpression of MMPs in sparse cultures could help explain early dissemination of potentially metastatic cells...
  57. ncbi Rescuing COX-2 inhibitors from the waste bin
    Adriana Albini
    J Natl Cancer Inst 97:859-60. 2005
  58. ncbi In vitro and in vivo tumor growth inhibition by a p16-mimicking peptide in p16INK4A-defective, pRb-positive human melanoma cells
    Douglas M Noonan
    Tumor Progression Section, Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi, Genova, Italy
    J Cell Physiol 202:922-8. 2005
    ....
  59. ncbi CXCL1/macrophage inflammatory protein-2-induced angiogenesis in vivo is mediated by neutrophil-derived vascular endothelial growth factor-A
    Patrizia Scapini
    Department of Pathology, Section of General Pathology, University of Verona, Verona, Italy
    J Immunol 172:5034-40. 2004
    ..Our observations delineate a novel mechanism by which CXCL1/MIP-2 induces neutrophil-dependent angiogenesis in vivo...
  60. ncbi A WT1 expressing metastatic human Kaposi sarcoma xenograft model
    Erzsebet Raso
    Department of Tumor Progression, National Institute of Oncology, Budapest, Hungary
    Pathol Oncol Res 10:22-5. 2004
    ..WT1 expression in the peripheral blood was only detectable in case of metastatic KS model suggesting it as a molecular marker of progression...
  61. ncbi A new tumor suppressor gene: invasion, metastasis, and angiogenesis as potential key targets
    Adriana Albini
    J Natl Cancer Inst 98:800-1. 2006
  62. ncbi Green tea polyphenol epigallocatechin-3-gallate inhibits the endothelin axis and downstream signaling pathways in ovarian carcinoma
    Francesca Spinella
    Laboratory of Molecular Pathology and Ultrastructure, Regina Elena Cancer Institute, Via delle Messi d oro, 156, 00158 Rome, Italy
    Mol Cancer Ther 5:1483-92. 2006
    ....
  63. ncbi Choking hypoxia-inducible factor 1alpha: a novel mechanism for connective tissue growth factor inhibition of angiogenesis
    Francesca Tosetti
    J Natl Cancer Inst 98:946-8. 2006
  64. ncbi The Akt inhibitor deguelin, is an angiopreventive agent also acting on the NF-kappaB pathway
    Claudia Ambrosini
    Molecular Oncology Laboratory, National Institute for Cancer Research Largo R Benzi 10, Italy
    Carcinogenesis 28:404-13. 2007
    ..These findings reveal a new therapeutic potential for deguelin in angioprevention and anti-angiogenic therapy...
  65. pmc Endothelin receptor blockade inhibits molecular effectors of Kaposi's sarcoma cell invasion and tumor growth in vivo
    Laura Rosanò
    Laboratories of Molecular Pathology and Ultrastructure and Immunology, Regina Elena Cancer Institute, and the Molecular Biology and Pathology Institute, Consiglio Nazionale delle Ricerche, Rome, Italy
    Am J Pathol 163:753-62. 2003
    ..Such activities can be blocked by the ET(A/B)R antagonists, which may be effective anti-angiogenic and anti-tumor molecules for the treatment of Kaposi's sarcoma...
  66. ncbi Identification of genes selectively regulated by IFNs in endothelial cells
    Stefano Indraccolo
    Department of Oncology and Surgical Sciences, Istituto Oncologico Veneto, Via Gattemelata 64, I 35128 Padua, Italy
    J Immunol 178:1122-35. 2007
    ..Moreover, we suggest that quantitative differences in the magnitude of the transcriptional activation of IFN-responsive genes could form the basis for cell-specific transcriptional signatures...
  67. ncbi The tumour microenvironment as a target for chemoprevention
    Adriana Albini
    IRCCS Multimedica Science and Technology Park, Viale Fantoli 15 16, Milan, 20138, Italy
    Nat Rev Cancer 7:139-47. 2007
    ..Finally, we make suggestions for more effective clinical implementation of this knowledge in preventive strategies...
  68. ncbi Cell density-dependent regulation of matrix metalloproteinase and TIMP expression in differently tumorigenic breast cancer cell lines
    Beatrice E Bachmeier
    Department Clinical Chemistry and Clinical Biochemistry, Hospital of Surgery, Ludwig Maximilians University, Nussbaumstr 20, D 80336 MUnchen, Germany
    Exp Cell Res 305:83-98. 2005
    ..Our data provide clear evidence that cell density regulates major MMPs and TIMPs which are controlled by AP-1 activity so that ultimately a major regulation pathway for the control of the invasive potential of tumor cells is presented...
  69. ncbi Metastasis signatures: genes regulating tumor-microenvironment interactions predict metastatic behavior
    Adriana Albini
    IRCCS Multimedica, Scientific and Technological Pole, via Fantoli 16 15, 20138, Milan, Italy
    Cancer Metastasis Rev 27:75-83. 2008
    ..Here we review these concepts and advance hypotheses on how gene expression of the primary tumor and the microenvironment can favor the spread of the metastasis seeds and how this knowledge can provide tools to secondary prevention...