G Musso

Summary

Country: Italy

Publications

  1. ncbi request reprint Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association
    Gianfranco Pagano
    Department of Internal Medicine, University of Turin, Turin, Italy
    Hepatology 35:367-72. 2002
  2. ncbi request reprint Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis
    Giovanni Musso
    Department of Internal Medicine, University of Turin, Turin, Italy
    Hepatology 37:909-16. 2003
  3. doi request reprint A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Hepatology 52:79-104. 2010
  4. ncbi request reprint Antioxidant therapy and drugs interfering with lipid metabolism: could they be effective in NAFLD patients?
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Curr Pharm Des 19:5297-313. 2013
  5. doi request reprint Interactions among bone, liver, and adipose tissue predisposing to diabesity and fatty liver
    Giovanni Musso
    Gradenigo Hospital, University of Turin, Turin, Italy Electronic address
    Trends Mol Med 19:522-35. 2013
  6. doi request reprint Association of obstructive sleep apnoea with the presence and severity of non-alcoholic fatty liver disease. A systematic review and meta-analysis
    G Musso
    Gradenigo Hospital, Turin, Italy
    Obes Rev 14:417-31. 2013
  7. pmc Sterol regulatory element-binding factor 2 (SREBF-2) predicts 7-year NAFLD incidence and severity of liver disease and lipoprotein and glucose dysmetabolism
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Diabetes 62:1109-20. 2013
  8. doi request reprint Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Prog Lipid Res 52:175-91. 2013
  9. doi request reprint Nonalcoholic steatohepatitis versus steatosis: adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism
    Giovanni Musso
    Gradenigo Hospital, Torino, Italy
    Hepatology 56:933-42. 2012
  10. doi request reprint A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose co-transport (SGLT) inhibitors: systematic review and meta-analysis of randomized trials
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Ann Med 44:375-93. 2012

Detail Information

Publications38

  1. ncbi request reprint Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association
    Gianfranco Pagano
    Department of Internal Medicine, University of Turin, Turin, Italy
    Hepatology 35:367-72. 2002
    ..The derangement of insulin regulation, often associated with the metabolic syndrome, may play a causal role in the pathogenesis of NASH...
  2. ncbi request reprint Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis
    Giovanni Musso
    Department of Internal Medicine, University of Turin, Turin, Italy
    Hepatology 37:909-16. 2003
    ..Our findings provide further rationale for more specific alimentary interventions, particularly in nonobese, nondiabetic normolipidemic NASH patients...
  3. doi request reprint A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Hepatology 52:79-104. 2010
    ..Other approaches yielded negative results...
  4. ncbi request reprint Antioxidant therapy and drugs interfering with lipid metabolism: could they be effective in NAFLD patients?
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Curr Pharm Des 19:5297-313. 2013
    ..However, as promising as these drug treatments may continue to be, they should be associated with diet and modifications in lifestyle. ..
  5. doi request reprint Interactions among bone, liver, and adipose tissue predisposing to diabesity and fatty liver
    Giovanni Musso
    Gradenigo Hospital, University of Turin, Turin, Italy Electronic address
    Trends Mol Med 19:522-35. 2013
    ..We will review recent advances in understanding the mechanisms of bone-liver-adipose tissue interaction predisposing to obesity, diabetes, NAFLD, and osteoporosis and their potential clinical implications. ..
  6. doi request reprint Association of obstructive sleep apnoea with the presence and severity of non-alcoholic fatty liver disease. A systematic review and meta-analysis
    G Musso
    Gradenigo Hospital, Turin, Italy
    Obes Rev 14:417-31. 2013
    ..The magnitude and direction of effects were unaffected by age, sex and BMI. In conclusion, OSAS is associated with an increased risk of NAFLD, NASH and fibrosis. OSAS patients should be screened for the presence and severity of NAFLD...
  7. pmc Sterol regulatory element-binding factor 2 (SREBF-2) predicts 7-year NAFLD incidence and severity of liver disease and lipoprotein and glucose dysmetabolism
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Diabetes 62:1109-20. 2013
    ..An SREBF-2 polymorphism predisposes individuals to NAFLD and associated cardiometabolic abnormalities and affects liver histology and glucose and lipid metabolism in biopsy-proven NAFLD...
  8. doi request reprint Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Prog Lipid Res 52:175-91. 2013
    ..The therapeutic implications and opportunities for normalizing cellular cholesterol homeostasis in these patients are also discussed...
  9. doi request reprint Nonalcoholic steatohepatitis versus steatosis: adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism
    Giovanni Musso
    Gradenigo Hospital, Torino, Italy
    Hepatology 56:933-42. 2012
    ..NASH, but not SS, showed an impaired pancreatic β-cell function. On multiple regression analysis, adipose IR index and postprandial adiponectin independently predicted liver histology and altered cardiometabolic parameters...
  10. doi request reprint A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose co-transport (SGLT) inhibitors: systematic review and meta-analysis of randomized trials
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Ann Med 44:375-93. 2012
    ..Current treatment of hyperglycemia in type 2 diabetes (T2DM) is often ineffective and has unwanted effects. Therefore, novel antidiabetic drugs are under development...
  11. doi request reprint Obstructive sleep apnea-hypopnea syndrome and nonalcoholic fatty liver disease: emerging evidence and mechanisms
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Semin Liver Dis 32:49-64. 2012
    ..Finally, we will provide suggestions for the management of NAFLD patients with suspected OSAS and recommendations for future research...
  12. doi request reprint Cholesterol-lowering therapy for the treatment of nonalcoholic fatty liver disease: an update
    Giovanni Musso
    Gradenigo Hospital, Corso Regina Margherita 8, Turin, Italy
    Curr Opin Lipidol 22:489-96. 2011
    ..To review recent human trials assessing cholesterol-lowering agents in nonalcoholic fatty liver disease (NAFLD)...
  13. doi request reprint Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Ann Med 43:617-49. 2011
    ..99). CONCLUSIONS. NAFLD warrants screening for cardio-metabolic risk and for progressive liver disease. The combination of three noninvasive tests with LB may optimally individuate patients with NASH, with or without advanced fibrosis...
  14. doi request reprint Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials
    G Musso
    Gradenigo Hospital, C so Regina Margherita 8, Turin, Italy
    Diabetologia 55:885-904. 2012
    ..The effect of proposed treatments on liver disease, glucose metabolism and cardiovascular risk in NAFLD is unknown. We reviewed the evidence for the management of liver disease and cardio-metabolic risk in NAFLD...
  15. doi request reprint Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: mechanisms and implications for metabolic disorders
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Curr Opin Lipidol 21:76-83. 2010
    ..To examine the role of gut microbiota in the regulation of host energy homeostasis and its role in the pathogenesis of obesity, diabetes and nonalcoholic fatty liver disease (NAFLD)...
  16. doi request reprint Emerging molecular targets for the treatment of nonalcoholic fatty liver disease
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Annu Rev Med 61:375-92. 2010
    ....
  17. pmc Obesity, diabetes, and gut microbiota: the hygiene hypothesis expanded?
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Diabetes Care 33:2277-84. 2010
    ....
  18. doi request reprint Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes
    Giovanni Musso
    Gradenigo Hospital, Department of Internal Medicine, University of Turin, Turin, Italy
    Annu Rev Med 62:361-80. 2011
    ....
  19. doi request reprint Effect of lectin-like oxidized LDL receptor-1 polymorphism on liver disease, glucose homeostasis, and postprandial lipoprotein metabolism in nonalcoholic steatohepatitis
    Giovanni Musso
    Gradenigo Hospital, Torino, Italy
    Am J Clin Nutr 94:1033-42. 2011
    ..Lectin-like oxidized LDL receptor-1 (LOX-1) has been connected to CVD risk in the general population and to insulin resistance and hepatic fibrogenesis in experimental models...
  20. doi request reprint Non-alcoholic fatty liver disease from pathogenesis to management: an update
    G Musso
    Gradenigo Hospital, Turin, Italy
    Obes Rev 11:430-45. 2010
    ..Larger- and longer-duration randomized trials assessing safety and benefits of drugs on patient-oriented outcomes are needed before pharmacological treatment can be routinely recommended for NASH...
  21. doi request reprint Lipoprotein metabolism mediates the association of MTP polymorphism with beta-cell dysfunction in healthy subjects and in nondiabetic normolipidemic patients with nonalcoholic steatohepatitis
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    J Nutr Biochem 21:834-40. 2010
    ..The impact of this polymorphism on the risk of diabetes and the efficacy of lipid-lowering therapies in restoring beta-cell function in NASH, even with normal fasting lipid values, warrant further investigation...
  22. ncbi request reprint Adipokines in NASH: postprandial lipid metabolism as a link between adiponectin and liver disease
    Giovanni Musso
    Department of Internal Medicine, University of Turin, Turin, Italy
    Hepatology 42:1175-83. 2005
    ..The mechanism(s) underlying these differences are unknown, but the type of dietary fat seems to play a role. These findings may have important pathogenetic and therapeutic implications in both liver and metabolic disease...
  23. ncbi request reprint Nitrosative stress predicts the presence and severity of nonalcoholic fatty liver at different stages of the development of insulin resistance and metabolic syndrome: possible role of vitamin A intake
    Giovanni Musso
    Emergency Medicine Department, Gradenigo Hospital, Turin, Italy
    Am J Clin Nutr 86:661-71. 2007
    ..Diet, adipokines, and nitrosative stress have been linked to both NAFLD and insulin resistance...
  24. ncbi request reprint Should nonalcoholic fatty liver disease be included in the definition of metabolic syndrome? A cross-sectional comparison with Adult Treatment Panel III criteria in nonobese nondiabetic subjects
    Giovanni Musso
    Gradenigo Hospital, Corso R Margherita 8, 10132 Turin, Italy
    Diabetes Care 31:562-8. 2008
    ..We compared the strength of the associations of ATP III criteria and of NAFLD to insulin resistance, oxidative stress, and endothelial dysfunction in nonobese nondiabetic subjects...
  25. doi request reprint Adiponectin gene polymorphisms modulate acute adiponectin response to dietary fat: Possible pathogenetic role in NASH
    Giovanni Musso
    Gradenigo Hospital Turin, Italy
    Hepatology 47:1167-77. 2008
    ....
  26. doi request reprint Association of liver disease with postprandial large intestinal triglyceride-rich lipoprotein accumulation and pro/antioxidant imbalance in normolipidemic non-alcoholic steatohepatitis
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Ann Med 40:383-94. 2008
    ..Dietary fat excess and antioxidant deficiency, altered lipid metabolism, and increased lipoperoxidation have been associated with non-alcoholic steatohepatitis (NASH), but the relative importance of each of these factors is unclear...
  27. doi request reprint Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)
    Giovanni Musso
    Gradenigo Hospital, 10132 Turin, Italy
    Prog Lipid Res 48:1-26. 2009
    ..We will review available data on different steps of hepatic lipid metabolism in NAFLD and recent advances in understanding molecular mechanisms underlying hepatic fat accumulation in these subjects...
  28. doi request reprint Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Am J Clin Nutr 89:558-67. 2009
    ..We hypothesized that altered GIP secretion may contribute to the pathogenesis of NAFLD...
  29. ncbi request reprint Postprandial triglyceride-rich lipoprotein metabolism and insulin sensitivity in nonalcoholic steatohepatitis patients
    M Cassader
    Department of Internal Medicine, University of Turin, Italy
    Lipids 36:1117-24. 2001
    ..This paper suggests that a fat load may be useful in early detection of atherogenic risk in the presence of otherwise normal fasting plasma lipids...
  30. ncbi request reprint Hypoadiponectinemia predicts the severity of hepatic fibrosis and pancreatic Beta-cell dysfunction in nondiabetic nonobese patients with nonalcoholic steatohepatitis
    Giovanni Musso
    Department of Internal Medicine, University of Turin, Italy
    Am J Gastroenterol 100:2438-46. 2005
    ....
  31. ncbi request reprint Polymorphism in microsomal triglyceride transfer protein: a link between liver disease and atherogenic postprandial lipid profile in NASH?
    Roberto Gambino
    Department of Internal Medicine, University of Turin, and Gradenigo Hospital, Italy
    Hepatology 45:1097-107. 2007
    ..Postprandial LDL-conjugated diene response predicted severe necroinflammation (OR: 3.3; CI 1.4-9.7; P=0.016) and fibrosis (OR: 2.8; CI 1.0-8,5; P=0.030); postprandial apoA1 fall predicts severe fibrosis (OR: 2.1; CI: 1.5-6.1; P=0.015)...
  32. doi request reprint Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH
    Giovanni Musso
    Gradenigo Hospital, Turin, Italy
    Hepatology 49:426-35. 2009
    ..Targeting postprandial lipemia, at least in at-risk TCF7L2 genotypes, may improve liver disease and glucose dysmetabolism in these patients...
  33. ncbi request reprint Associations between serum uric acid and adipokines, markers of inflammation, and endothelial dysfunction
    S Bo
    Department of Internal Medicine, University of Turin, 10126 Turin, Italy
    J Endocrinol Invest 31:499-504. 2008
    ..The aim of the study was to evaluate the association between uric acid and adipokines, markers of inflammation, oxidative stress, and endothelial dysfunction, which are all linked to cardiovascular disease...
  34. doi request reprint Type 1 autoimmune hepatitis and adipokines: new markers for activity and disease progression?
    Marilena Durazzo
    Department of Internal Medicine, University of Turin, Turin, Italy
    J Gastroenterol 44:476-82. 2009
    ..There is some evidence suggesting a link between adiponectin-biliary function and liver disease. The aim of this study was to clarify the behavior of adipokines in autoimmune hepatitis type 1...
  35. doi request reprint Glucose-dependent insulinotropic polypeptide: from pathophysiology to therapeutic opportunities in obesity-associated disorders
    E Paschetta
    Department of Internal Medicine, University of Turin, Turin, Italy Helgelandssykehu set, Mosjøen, Norway Gradenigo Hospital, Turin, Italy
    Obes Rev 12:813-28. 2011
    ..Emerging evidence also suggests that the metabolic benefits of bypass surgery are mediated, at least in part, by surgical removal of GIP-secreting K-cells in the upper small intestine...
  36. ncbi request reprint Microsomal triglyceride transfer protein 493-T variant is associated with resistin levels and C-reactive protein
    Roberto Gambino
    Department of Internal Medicine, University of Torino, 10126 Torino, Italy
    Clin Biochem 40:1219-24. 2007
    ..We hypothesized that MTP polymorphism could be associated to LDL-cholesterol levels and proinflammatory cytokines, such as resistin...
  37. pmc Transcription factor 7-like 2 (TCF7L2) polymorphism and hyperglycemia in an adult Italian population-based cohort
    Roberto Gambino
    Department of Internal Medicine, University of Turin, Torino, Italy
    Diabetes Care 33:1233-5. 2010
    ..To assess whether TCF7L2 polymorphism has a role in the deterioration of glycemic control...
  38. ncbi request reprint Association between postprandial LDL conjugated dienes and the severity of liver fibrosis in NASH
    Giovanni Musso
    Hepatology 43:1169-70. 2006