Research Topics
Genomes and GenesSpecies | P MulateroSummaryCountry: Italy Publications
| Collaborators
|
Detail Information
Publications
Comparison of confirmatory tests for the diagnosis of primary aldosteronismPaolo Mulatero
Centro Ipertensione Ospedale San Vito, Strada San Vito 34, 10133, Torino, Italy
J Clin Endocrinol Metab 91:2618-23. 2006..The FST is considered by many to be the most reliable but is more complex and expensive...
Effect of adrenocorticotropic hormone stimulation during adrenal vein sampling in primary aldosteronismSilvia Monticone
Department of Physiology, Georgia Health Sciences University, Augusta, GA, USA
Hypertension 59:840-6. 2012..Stringent criteria for cannulation should be used to have a high consistency of the diagnosis...
18-hydroxycorticosterone, 18-hydroxycortisol, and 18-oxocortisol in the diagnosis of primary aldosteronism and its subtypesPaolo Mulatero
Department of Medicine and Experimental Oncology, Division of Internal Medicine and Hypertension Unit, University of Torino, and Clinical Chemistry Laboratory, San Giovanni Battista University Hospital, Via Genova 3, 10126 Torino, Italy
J Clin Endocrinol Metab 97:881-9. 2012..Diagnosis of primary aldosteronism (PA) is made by screening, confirmation testing, and subtype diagnosis (computed tomography scan and adrenal vein sampling). However, some tests are costly and unavailable in most hospitals...
Aldosterone as an independent factor in cerebrovascular damagePaolo Mulatero
Division of Internal Medicine and Hypertension, Department of Medicine and Experimental Oncology, University of Torino, Torino, Italy
Clin Exp Hypertens 30:785-97. 2008..Herein we review the pathophysiology of aldosterone action in the brain and the clinical and experimental studies on the detrimental effects of aldosterone in the brain...
A particular phenotype in a girl with aldosterone synthase deficiencyTracy A Williams
Department of Medicine and Experimental Oncology, Hypertension Unit, San Vito Hospital, Strada San Vito 34, 10133 Turin, Italy
J Clin Endocrinol Metab 89:3168-72. 2004..This case of ASD is of particular interest because despite the apparent lack of aldosterone synthase activity, the patient displays low-normal aldosterone levels, thus raising the question of its source...
Prevalence and characteristics of familial hyperaldosteronism: the PATOGEN study (Primary Aldosteronism in TOrino-GENetic forms)Paolo Mulatero
Department of Medicine and Experimental Oncology, Division of Internal Medicine and Hypertension, University of Torino, Torino, Italy
Hypertension 58:797-803. 2011....
Diagnosis and treatment of primary aldosteronismPaolo Mulatero
Division of Internal Medicine and Hypertension, Department of Medicine and Experimental Oncology, University of Torino, 10126, Torino, Italy
Rev Endocr Metab Disord 12:3-9. 2011..In the present review we describe briefly the published diagnostic strategies of the Guidelines, highlighting new evidence that has become recently available and discuss issues that still need to be addressed by future research...
Evaluation of primary aldosteronismPaolo Mulatero
Division of Internal Medicine and Hypertension, Department of Medicine and Experimental Oncology, University of Torino, Torino, Italy
Curr Opin Endocrinol Diabetes Obes 17:188-93. 2010..The purpose of this review is to briefly summarize current knowledge on diagnosis and treatment of primary aldosteronism, the most frequent cause of endocrine hypertension...
Mineralocorticoid receptor blockade in the protection of target organ damagePaolo Mulatero
Ospedale San Vito, Strada San Vito 34, 10133 Torino, Italy
Cardiovasc Hematol Agents Med Chem 4:75-91. 2006..We also discuss the pharmacological and clinical differences between the two available mineralocorticoid receptor blockers, spironolactone and eplerenone...
CYP11B2 -344T/C gene polymorphism and blood pressure in patients with acromegalyPaolo Mulatero
Division of Internal Medicine, Hypertension Unit, Ospedale San Vito, Strada San Vito 34, 10133 Torino, Italy
J Clin Endocrinol Metab 91:5008-12. 2006..The pathogenesis of increased blood pressure (BP) in acromegaly is unclear, and the role of IGF-I levels and the renin-angiotensin-aldosterone system (RAAS) in this disease remains controversial...
[Role of aldosterone in the metabolic syndrome]P Mulatero
Divisione di Medicina Interna e Ipertensione, Universita di Torino, Torino
G Ital Nefrol 23:406-14. 2006..Higher rates of cardiovascular events have been recently reported in primary aldosteronism: they could be partly due to the increased prevalence of the metabolic syndrome in this disorder...
Confirmatory tests in the diagnosis of primary aldosteronismP Mulatero
Division of Internal Medicine, Department of Medicine and Experimental Oncology, University of Torino, Torino, Italy
Horm Metab Res 42:406-10. 2010..Herein we discuss the diagnostic protocols for these confirmatory tests and highlight both the advantages and contraindications and we discuss studies in which these confirmatory tests have been compared...
Diagnosis and treatment of low-renin hypertensionPaolo Mulatero
Department of Medicine and Experimental Oncology, Division of Internal Medicine and Hypertension, University of Torino, Italy
Clin Endocrinol (Oxf) 67:324-34. 2007..The present review will discuss the differential diagnosis of LRH subtypes and the most appropriate treatment options based on the pathophysiological background of this condition...
Differential diagnosis of primary aldosteronism subtypesPaolo Mulatero
Division of Internal Medicine and Hypertension, AOU San Giovanni Battista, Via Genova 3, 10126, Torino, Italy
Curr Hypertens Rep 11:217-23. 2009..This article reviews the strategies to correctly identify PA subtypes, underlining the central role of adrenal vein sampling...
Impact of different diagnostic criteria during adrenal vein sampling on reproducibility of subtype diagnosis in patients with primary aldosteronismPaolo Mulatero
Department of Medicine and Experimental Oncology, University of Torino, Torino, Italy
Hypertension 55:667-73. 2010..75. In conclusion, permissive criteria for successful cannulation and lateralization on AVS achieve poor diagnostic reproducibility and should be avoided...
Roles of clinical criteria, computed tomography scan, and adrenal vein sampling in differential diagnosis of primary aldosteronism subtypesPaolo Mulatero
Department of Medicine and Experimental Oncology, University of Torino, 10126 Torino, Italy
J Clin Endocrinol Metab 93:1366-71. 2008..Because AVS is not widely available, a list of clinical criteria that indicate the presence of an aldosterone-producing adenoma (APA) has been suggested...
Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continentsPaolo Mulatero
Hypertension Unit, Department of Medicine and Experimental Oncology, University of Torino, 10133 Turin, Italy
J Clin Endocrinol Metab 89:1045-50. 2004..In conclusion, the wide use of the ARR as a screening test in hypertensive patients led to a marked increase in the detection rate of PA...
Genetics of primary aldosteronismPaolo Mulatero
Department of Medicine and Experimental Oncology, San Vito Hospital, University of Torino, Torino, Italy
J Hypertens 22:663-70. 2004..Here, we review the genetic and the phenotypic features of the familial forms, the genetic variants that influence the sporadic forms and the structure and regulation of the CYP11B1 and CYP11B2 genes...
Blood pressure in patients with primary aldosteronism is influenced by bradykinin B(2) receptor and alpha-adducin gene polymorphismsPaolo Mulatero
Department of Medicine and Experimental Oncology, Hypertension Unit, San Vito Hospital, University of Turin, Strada San Vito 34, 10133 Turin, Italy
J Clin Endocrinol Metab 87:3337-43. 2002..0% of the systolic and diastolic blood pressure variance, respectively. These data suggest that genetic variants of alpha-adducin and the bradykinin B(2)-R influence the blood pressure levels in patients with primary aldosteronism...
Hypertension, genotype and oral contraceptivesPaolo Mulatero
Department of Medicine and Experimental Oncology, Hypertension Unit, San Vito Hospital, University of Torino, S San Vito 34 10133 Torino, Italy
Pharmacogenomics 3:57-63. 2002..In this article, the epidemiology and the pathogenesis of OCIH are reviewed with particular emphasis on the genetic influence in light of the most recent studies in this field...
Glucocorticoid remediable aldosteronism: low morbidity and mortality in a four-generation italian pedigreePaolo Mulatero
Department of Medicine and Experimental Oncology, Hypertension Unit, San Vito Hospital, University of Turin, Strada San Vito 34, 10133 Turin, Italy
J Clin Endocrinol Metab 87:3187-91. 2002..However, none of the biochemical or genetic parameters investigated could explain the mild phenotype of the family...
Drug effects on aldosterone/plasma renin activity ratio in primary aldosteronismPaolo Mulatero
Department of Medicine and Experimental Oncology, Hypertension Unit, University of Torino, Torino, Italy
Hypertension 40:897-902. 2002..The high rate of false-negative diagnoses in patients undergoing irbesartan treatment requires confirmation in a higher number of patients...
KCNJ5 mutations in European families with nonglucocorticoid remediable familial hyperaldosteronismPaolo Mulatero
Division of Internal Medicine and Hypertension, University of Torino, Torino, Italy
Hypertension 59:235-40. 2012..In conclusion, we describe herein a new mutation in the KCNJ5 potassium channel associated with FH-III, responsible for marked alterations of channel function but associated with a mild clinical and hormonal phenotype...
Adrenal endothelin-1 levels are not associated with aldosterone secretion in primary aldosteronismF Morello
Fourth Division of Internal Medicine and Hypertension Unit, San Giovanni Battista Hospital of Torino, University of Torino, Torino, Italy
Eur J Endocrinol 160:453-8. 2009..Hence, the existence of a feedforward loop involving ETs and aldosterone has been speculated in primary aldosteronism (PA). In the present study, we sought to examine ET-1 secretion from the adrenal glands in patients with PA...
CYP11B2 gene polymorphisms in idiopathic hyperaldosteronismP Mulatero
Department of Medicine and Experimental Oncology, Hypertension Unit, University of Torino, Torino, Italy
Hypertension 35:694-8. 2000..Our results suggest that variations in the CYP11B2 gene may contribute to dysregulation of aldosterone synthesis and lead to susceptibility to IHA...
Blood pressure levels, left ventricular mass and function are correlated with left atrial volume in mild to moderate hypertensive patientsA Milan
Hypertension Unit, Department of Medicine and Experimental Oncology, Division of Internal Medicine, University of Torino, Torino, Italy
J Hum Hypertens 23:743-50. 2009..These findings highlight the importance of left atrium evaluation in adult, relatively young, essential hypertensive patients...
Absence of D147E mutation of CYP11B2 gene in hypertensive patients with increased corticosterone and aldosterone productionP Mulatero
Department of Medicine and Experimental Oncology, Hypertension Unit, University of Torino, Italy
Eur J Endocrinol 144:397-400. 2001..A gene conversion between the CYP11B1 and CYP11B2 genes could be responsible for such a substitution...
Angiotensin-converting enzyme and angiotensinogen gene polymorphisms are non-randomly distributed in oral contraceptive-induced hypertensionP Mulatero
Department of Medicine and Experimental Oncology, San Vito Hospital, University of Torino, Italy
J Hypertens 19:713-9. 2001....
Rapid cortisol assay during adrenal vein sampling in patients with primary aldosteronismGiulio Mengozzi
Clinical Chemistry Laboratory and Divisions of Radiology, Internal Medicine and Hypertension, Surgery, University of Torino, Torino, Italy
Clin Chem 53:1968-71. 2007..Technical difficulties with this procedure may be overcome by monitoring cortisol concentrations in the different sampling sites during catheterization...
Primary aldosteronism: who should be screened?S Monticone
Department of Medicine and Experimental Oncology, D ivision of Internal Medicine and Hypertension, University of Torino, Torino, Italy
Horm Metab Res 44:163-9. 2012....
Recent advances in diagnosis and treatment of primary aldosteronismF Veglio
Hypertension Unit, Department of Medicine and Experimental Oncology, S Vito Hospital, University of Turin, Turin, Italy
Minerva Med 94:259-65. 2003..If bilateral aldosterone excess is demonstrated, an aldosterone receptor antagonist should be administered. This article reviews and discusses the new data about prevalence, diagnosis and treatment of primary aldosteronism...
Bradykinin B2 receptor gene (-58T/C) polymorphism influences baroreflex sensitivity in never-treated hypertensive patientsAlberto Milan
Department of Medicine and Experimental Oncology, Hypertension Unit, University of Torino, Italy
J Hypertens 23:63-9. 2005..Recent studies suggest that about 40% of baroreflex variation, an index of cardiac autonomic control, is influenced by genetic factors...
Aldosterone does not modify gene expression in human endothelial cellsA Verhovez
Department of Internal Medicine, University of Torino, Torino, Italy
Horm Metab Res 44:234-8. 2012....
Peripheral adrenergic system and hypertensionF Veglio
Department of Medicine and Experimental Oncology Hypertension Unit, S. Vito Hospital, Torino, Italy
Clin Exp Hypertens 23:3-14. 2001..The importance of these findings could provide an assessment of alpha1-peripheral receptors with possible future clinical implications in the pathophysiology and treatment of hypertension...
Baroreflex sensitivity is impaired in essential hypertensives with central obesityS Del Colle
Hypertension Unit, Department of Medicine and Experimental Oncology, University of Turin, Molinette Hospital, Turin, Italy
J Hum Hypertens 21:473-8. 2007..Owing to its association with abdominal fat distribution and subsequently insulin resistance, BRS could represent a further and reliable index for evaluation of global cardiovascular risk in hypertensive patients...
Impairment of cardiovascular autonomic pattern in obese adolescents with Type 2 diabetes mellitusF Cerutti
Department of Pediatrics, University of Turin, Piazza Polonia 96, 10126 Turin, Italy
J Endocrinol Invest 33:539-43. 2010..In conclusion, T2DM adolescents are characterized by a more marked IR reduced β-cell function in comparison to non-diabetic obese. These modifications may lead to an early impairment of the autonomic pattern...
Alpha1-adrenergic receptor subtypes in peripheral blood lymphocytes of essential hypertensivesF Veglio
Department of Medicine and Experimental Oncology, Hypertension Unit, University of Turin, Turin, Italy
J Hypertens 19:1847-54. 2001....
Assessing resting heart rate in adolescents: determinants and correlatesF Rabbia
Department of Medicine and Experimental Oncology, University of Turin, Italy
J Hum Hypertens 16:327-32. 2002..In conclusion, resting heart rate in adolescents is related to several methodological, constitutional and environmental factors that have to be taken into account when assessing heart rate values and constructing tables of normal values...
Recent advances in diagnosis and treatment of pheochromocytomaF Veglio
Hypertension Unit, Department of Medicine and Experimental Oncology, S Vito Hospital, University of Turin, Turin, Italy
Minerva Med 94:267-71. 2003..An appropriate pre-, intra- and postoperative medical management of the patient is mandatory. In the absence of optimal medical treatment, intraoperative mortality reaches 50%...
Vasoactive hormones induce nitric oxide synthase mRNA expression and nitric oxide production in human endothelial cells and monocytesM Schena
Department of Medicine and Experimental Oncology, University of Turin, Italy
Am J Hypertens 12:388-97. 1999..Human endothelial cells and monocytes express the NOS-2 and NOS-3 mRNA and the inducible NOS-2 mRNA expression increases after vasoactive hormone stimulation...
Efficacy of antihypertensive treatment based on plasma renin activity: An open label observational studyGiannina Leotta
Hypertension Unit, Department of Medicine and Experimental Oncology, University of Turin, Torino, Italy
Blood Press 19:218-24. 2010....
Primary aldosteronism (PA) and endothelial progenitor cell (EPC) bioavailabilityAndrea Verhovez
Department of Medicine and Experimental Oncology, Division of Internal Medicine and Hypertension Unit, University of Torino, Torino, Italy
Clin Endocrinol (Oxf) 69:528-34. 2008..Aldosterone has been reported to decrease EPC proliferation in rats...
Effects of birth weight on spontaneous baroreflex sensitivity in adult lifeGiannina Leotta
Divisione di Medicina Interna e Ipertensione, Ospedale S Vito, Universita di Torino, Strada S Vito 34, 10133 Turin, Italy
Nutr Metab Cardiovasc Dis 17:303-10. 2007..The objective of the present study was to investigate if baroreflex sensitivity (BRS) in adulthood is associated with birth weight...
Teratocarcinoma-derived growth factor-1 is upregulated in aldosterone-producing adenomas and increases aldosterone secretion and inhibits apoptosis in vitroTracy A Williams
Department of Medicine and Experimental Oncology, University of Torino, Torino, Italy
Hypertension 55:1468-75. 2010....
Protective effect of spironolactone on endothelial cell apoptosisTracy A Williams
Department of Medicine and Experimental Oncology, Hypertension Unit, University of Torino, Italy
Endocrinology 147:2496-505. 2006....
Baroreflex sensitivity correlates with left ventricular morphology and diastolic function in essential hypertensionAlberto Milan
Department of Medicine and Experimental Oncology, Hypertension Unit, University of Torino, Turin, Italy
J Hypertens 25:1655-64. 2007..This study sought to assess the association between BRS and left ventricular morphology and function...
Diagnosis of primary aldosteronism: from screening to subtype differentiationPaolo Mulatero
Department of Medicine and Experimental Oncology, Hypertension Unit, University of Turin, Turin 10133, Italy
Trends Endocrinol Metab 16:114-9. 2005....
Antihypertensive drugs and the sympathetic nervous systemSara Del Colle
Division of Internal Medicine, Hypertension Unit, Department of Medicine and Experimental Oncology, University of Turin, Molinette Hospital, Turin, Italy
J Cardiovasc Pharmacol 50:487-96. 2007....
Role of HSD11B2 polymorphisms in essential hypertension and the diuretic response to thiazidesTracy A Williams
Hypertension Unit, Department of Medicine and Experimental Oncology, University of Torino, Torino, Italy
Kidney Int 67:631-7. 2005..Loss-of-function mutations in the gene encoding 11beta HSD2 (HSD11B2) result in overstimulation of the MR and cause salt-sensitive hypertension...
[Assessment of cardiovascular risk in hypertensive patients: comparison among scores]Sara Del Colle
Centro per la Diagnosi e la Cura dell Ipertensione Arteriosa, Dipartimento di Medicina e Oncologia Sperimentale, Ospedale San Vito, Torino
Ital Heart J Suppl 5:694-704. 2004....
QT interval in patients with primary aldosteronism and low-renin essential hypertensionSimona Maule
Autonomic Unit and Hypertension Unit, Department of Medicine and Experimental Oncology, S Vito Hospital, University of Turin, Turin, Italy
J Hypertens 24:2459-64. 2006..The aim of the present study was to evaluate the QT interval in patients with primary aldosteronism and low-renin essential hypertension (LREH)...
LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanismsFulvio Morello
SCU Medicina d Urgenza, San Giovanni Battista Hospital and Molecular Biotechnology Center, Torino, Italy
Atherosclerosis 207:38-44. 2009..While oxysterol LXR agonists can increase the endothelial-leukocyte interaction, synthetic LXR agonists are anti-atherogenic and anti-inflammatory. Mechanistic differences may underlie such findings...
Salt intake and hypertension therapyAlberto Milan
Department of Medicine and Experimental Oncology, University of Turin, Italy
J Nephrol 15:1-6. 2002..Reduced sodium intake associated with other dietary changes (such as weight loss, and increasing potassium, calcium and magnesium intake) are important instruments for the prevention and therapy of hypertension...
A time-resolved fluoroimmunoassay for 18-oxocortisol and 18-hydroxycortisol. Development of a monoclonal antibody to 18-oxocortisolStefania Morra di Cella
Department of Internal Medicine, University of Torino, Italy
J Steroid Biochem Mol Biol 82:83-8. 2002..The TR-FIA technique was more sensitive and had a greater precision than the ELISA technique for both steroids...
Prolonged QT interval and reduced heart rate variability in patients with uncomplicated essential hypertensionSimona Maule
Autonomic Unit and Hypertension Unit, Department of Medicine and Experimental Oncology, S Giovanni Battista Hospital, University of Turin, Turin, Italy
Hypertens Res 31:2003-10. 2008..Further studies are warranted to evaluate whether the combination of such markers can identify hypertensive patients at risk for life-threatening arrhythmias and sudden death. (Hypertens Res 2008; 31: 2003-2010)...
Captopril test can give misleading results in patients with suspect primary aldosteronismPaolo Mulatero
Hypertension 50:e26-7. 2007
Letter regarding article by Hood et al, "The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio"Paolo Mulatero
Circulation 117:e151; author reply e152. 2008
Prevalence and characteristics of the metabolic syndrome in primary aldosteronismFrancesco Fallo
Department of Medical and Surgical Sciences, Universita di Padova, Via Ospedale 105, 35128 Padua, Italy
J Clin Endocrinol Metab 91:454-9. 2006..Aldosterone excess has been found to be associated with glucose disorders and may contribute to cardiovascular damage...
Adiponectin and insulin sensitivity in primary aldosteronismFrancesco Fallo
Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
Am J Hypertens 20:855-61. 2007..We evaluated the relationship between adiponectin and insulin sensitivity in primary aldosteronism, with and without metabolic syndrome, compared with essential hypertension...
Primary aldosteronism, a major form of low renin hypertension: from screening to diagnosisGilberta Giacchetti
Division of Endocrinology, Universita Politecnica delle Marche, Ancona, 60020, Italy
Trends Endocrinol Metab 19:104-8. 2008..Finally, subtype forms and lateralization of aldosterone production should be established by bilateral adrenal venous sampling, despite its technical difficulty and varying criteria for success...
11beta-Hydroxysteroid dehydrogenase type 2 activity is associated with left ventricular mass in essential hypertensionNicola Glorioso
Hypertension and Cardiovascular Prevention Centre, ASL n 1 University of Sassari, Italy
Eur Heart J 26:498-504. 2005..The mineralocorticoid receptor and 11beta-HSD2 are co-expressed in human heart. We investigated whether LVM may be regulated by glucocorticoids in EH patients...
A new form of hereditary primary aldosteronism: familial hyperaldosteronism type IIIPaolo Mulatero
J Clin Endocrinol Metab 93:2972-4. 2008
Further evidence for linkage of familial hyperaldosteronism type II at chromosome 7p22 in Italian as well as Australian and South American familiesNorlela Sukor
Endocrine Hypertension Research Center, University of Queensland School of Medicine, Greenslopes Hospital, Brisbane, Australia
J Hypertens 26:1577-82. 2008....
The metabolic syndrome in primary aldosteronismFrancesco Fallo
Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, Via Ospedale 105, Padova, Italy
Curr Hypertens Rep 9:106-11. 2007..Higher rates of cardiovascular events reported in primary aldosteronism could be due in part to the increased prevalence of the metabolic syndrome in this disorder...
The metabolic syndrome in primary aldosteronismFrancesco Fallo
Department of Medical and Surgical Sciences, Clinica Medica 3, University of Padova, Via Ospedale 105, 35128 Padova, Italy
Curr Diab Rep 8:42-7. 2008..Higher rates of cardiovascular events reported in primary aldosteronism could be due in part to the increased prevalence of the metabolic syndrome in this disorder...
