Research Topics
| Marco MulaSummaryCountry: Italy Publications
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Detail Information
Publications
Treatment of anxiety disorders in epilepsy: an evidence-based approachMarco Mula
Division of Neurology, Trinity Hospital, Borgomanero, Italy
Epilepsia 54:13-8. 2013..In these patients, careful clinical monitoring is indicated, in selected cases, for potential seizure precipitation and side effects due to pharmacodynamics interactions...
The role of hippocampal sclerosis in antiepileptic drug-related depression in patients with epilepsy: a study on levetiracetamMarco Mula
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, United Kingdom
Seizure 15:405-8. 2006..The aim of our study was to clarify whether patients with temporal lobe epilepsy (TLE) and HS were also at risk during therapy with levetiracetam (LEV)...
Phenomenology of obsessive compulsive disorder in patients with temporal lobe epilepsy or tourette syndromeMarco Mula
The Neuropsychiatry Research Group, Department of Clinical and Experimental Medicine, Section of Neurology, Amedeo Avogadro University, C so Mazzini, 18, Novara 28100, Italy
J Neuropsychiatry Clin Neurosci 20:223-6. 2008..Content of obsessive-compulsive themes focuses on sexuality and impulsiveness in Tourette syndrome and existential thoughts in temporal lobe epilepsy...
Clinical and psychopathological definition of the interictal dysphoric disorder of epilepsyMarco Mula
Department of Neurology, Amedeo Avogadro University, Novara, Italy
Epilepsia 49:650-6. 2008..We sought to investigate whether IDD occurs only in patients with epilepsy and to validate IDD features against DSM-IV criteria...
Antiepileptic drug-induced mania in patients with epilepsy: what do we know?Marco Mula
The Neuropsychiatry Research Group, Department of Neurology, Amedeo Avogadro University, Novara, Italy
Epilepsy Behav 9:265-7. 2006..This article explores the relationship between antiepileptic drugs and mania in patients with epilepsy, with special emphasis on the clinical pathophysiology of this phenomenon...
The neurobiology and clinical significance of depersonalization in mood and anxiety disorders: a critical reappraisalMarco Mula
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, Section of Psychiatry, University of Pisa, Via Roma, 67 56100 Pisa, Italy
J Affect Disord 99:91-9. 2007....
The role of aura in psychopathology and dissociative experiences in epilepsyMarco Mula
Department of Neurology, Amedeo Avogadro University, C so Mazzini, 18 28100 Novara, Italy
J Neuropsychiatry Clin Neurosci 18:536-42. 2006....
Are psychiatric adverse events of antiepileptic drugs a unique entity? A study on topiramate and levetiracetamMarco Mula
Department of Clinical and Experimental Medicine, Section of Neurology, Amedeo Avogadro University, Novara, Italy
Epilepsia 48:2322-6. 2007..To investigate the hypothesis that some patients with epilepsy are generally prone to develop psychiatric adverse events (PAEs) during antiepileptic drug (AED) therapy irrespective of the mechanism of action of the drugs...
The role of anticonvulsant drugs in anxiety disorders: a critical review of the evidenceMarco Mula
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, University of Pisa, Pisa, Italy
J Clin Psychopharmacol 27:263-72. 2007..Further investigation is needed to determine in what circumstances they should be used in individuals who are partially responsive or nonresponsive to conventional therapy...
Suicidal ideation in epilepsy and levetiracetam therapyMarco Mula
The Neuropsychiatry Research Group, Department of Neurology, Amedeo Avogadro University, Novara, Italy
Epilepsy Behav 11:130-2. 2007..Psychopathological characteristics of suicidal ideation were consistent in all subjects and similar to some features that are described as typical of the so-called interictal dysphoric disorder of epilepsy...
On the prevalence of bipolar disorder in epilepsyMarco Mula
Department of Neurology, Amedeo Avogadro University, Novara, Italy
Epilepsy Behav 13:658-61. 2008....
Antiepileptic drug-induced cognitive adverse effects: potential mechanisms and contributing factorsMarco Mula
Department of Clinical and Experimental Medicine, Department of Neurology, Amedeo Avogadro University, Novara, Italy
CNS Drugs 23:121-37. 2009..Finally, the mood status of the patient and clinical relevance of the information obtained by neuropsychological testing represent important variables that need to be taken into account when discussing cognitive adverse effects of AEDs...
The role of hippocampal sclerosis in topiramate-related depression and cognitive deficits in people with epilepsyMarco Mula
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, England, UK
Epilepsia 44:1573-7. 2003..To clarify the role of hippocampal sclerosis (HS) in developing psychiatric and cognitive adverse events during therapy with topiramate (TPM) in patients with temporal lobe epilepsy (TLE)...
Psychiatric adverse events in patients with epilepsy and learning disabilities taking levetiracetamMarco Mula
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, UK
Seizure 13:55-7. 2004..To investigate the prevalence and psychopathological features of psychiatric adverse events (PAEs) in patients with learning disabilities (LD) in therapy with levetiracetam (LEV)...
The role of titration schedule of topiramate for the development of depression in patients with epilepsyMarco Mula
Section of Neurology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University, Novara, Italy
Epilepsia 50:1072-6. 2009....
Use of psychotropic drugs in patients with epilepsy: interactions and seizure riskMarco Mula
Department of Neurology, Amedeo Avogadro University, C so Mazzini, 18 28100 Novara, Italy
Expert Rev Neurother 4:953-64. 2004..On the other hand, the main factors that may affect choice of therapy, patients' response and compliance, when prescribing antidepressants or antipsychotic drugs, drug interactions and the potential proconvulsive risk are reviewed...
Negative effects of antiepileptic drugs on mood in patients with epilepsyMarco Mula
Department of Clinical and Experimental Medicine, Section of Neurology, Amedeo Avogadro University, Novara, Italy
Drug Saf 30:555-67. 2007..Individuals with a personal or family history of depression should be carefully followed after initiation of therapy with a new antiepileptic drug, especially if structural brain abnormalities such as hippocampal sclerosis are present...
Manic/hypomanic symptoms and quality of life measures in patients with epilepsyMarco Mula
The Neuropsychiatry Research Group and the Epilepsy Centre, Department of Neurology, Amedeo Avogadro University, C so Mazzini, 18, 28100 Novara, Italy
Seizure 18:530-2. 2009..In this study, we sought to investigate their relationship with social and health-related QoL measures in patients with epilepsy...
Clinical correlates of schizotypy in patients with epilepsyMarco Mula
Department of Neurology, Amedeo Avogadro University, Novara 28100, Italy
J Neuropsychiatry Clin Neurosci 20:441-6. 2008..Schizotypal symptoms correlated with early onset of the seizures and a diagnosis of temporal lobe epilepsy, further confirming an association between psychoses and epilepsy...
Clinical correlates of pathological gambling symptoms in patients with epilepsyAndrea E Cavanna
Department of Neurology, Amedeo Avogadro University, Novara, Italy
Epilepsia 49:1460-4. 2008..Alterations in the mesolimbic reward system could represent the putative neuropathological substrate for this multifaceted clinical picture...
Interictal dysphoric disorder and periictal dysphoric symptoms in patients with epilepsyMarco Mula
Department of Neurology, Amedeo Avogadro University, Novara, Italy
Epilepsia 51:1139-45. 2010..This study aimed at identifying clinical correlates of the IDD, with special attention to the relationship between symptoms and seizures...
Distinguishing affective depersonalization from anhedonia in major depression and bipolar disorderMarco Mula
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, University of Pisa, 56100 Pisa, Italy
Compr Psychiatry 51:187-92. 2010....
Obsessionality, obsessive-compulsive disorder, and temporal lobe epilepsyFrancesco Monaco
Neuropsychiatry Research Group and the Epilepsy Clinic, Department of Neurology, Amedeo Avogadro University, Novara, Italy
Epilepsy Behav 7:491-6. 2005....
Clinical correlates of depersonalization symptoms in patients with bipolar disorderMarco Mula
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, University of Pisa, Italy
J Affect Disord 115:252-6. 2009....
Topiramate and word-finding difficulties in patients with epilepsyMarco Mula
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, UK
Neurology 60:1104-7. 2003..CONCLUSIONS: The presence of word-finding difficulties seems to be a titration schedule independent phenomenon that occurs in a subgroup of patients with a specific biologic vulnerability...
Topiramate and psychiatric adverse events in patients with epilepsyMarco Mula
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Epilepsia 44:659-63. 2003..CONCLUSIONS: We found that PAEs associated with TPM were related to the titration schedule of the drug and that a unique patient profile is suggested by the clinical history...
Different temperament and character dimensions correlate with panic disorder comorbidity in bipolar disorder and unipolar depressionMarco Mula
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, University of Pisa, Via Roma 67, 56100 Pisa, Italy
J Anxiety Disord 22:1421-6. 2008..This study aimed to investigate temperament and character correlates of panic disorder (PD) comorbidity in euthymic patients with bipolar disorder (BD) or unipolar depression (UD)...
The importance of being seizure free: topiramate and psychopathology in epilepsyMarco Mula
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Epilepsy Behav 4:430-4. 2003..We observed that psychopathology was related to seizure control in a subgroup of patients. The role of forced normalization, interlinked with interactions with other antiepileptic drugs, could be relevant...
Validity and reliability of the Structured Clinical Interview for Depersonalization-Derealization Spectrum (SCI-DER)Marco Mula
Department of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, University of Pisa, Italy
Neuropsychiatr Dis Treat 4:977-86. 2008..It significantly discriminated subjects with any diagnosis of mood and anxiety disorders from controls and subjects with depersonalization disorder from controls. The hypothesized structure of the instrument was confirmed empirically...
The clinical spectrum of bipolar symptoms in epilepsy: a critical reappraisalMarco Mula
Division of Neurology, Maggiore Hospital, Amedeo Avogadro University, Novara, Italy
Postgrad Med 122:17-23. 2010..Epileptologists need to be aware of the large and complex spectrum of bipolar symptoms in epilepsy to inform patients and their families, as well as to develop appropriate treatment strategies...
Suicidality in epilepsy and possible effects of antiepileptic drugsMarco Mula
Department of Clinical and Experimental Medicine, Amedeo Avogadro University, Division of Neurology, University Hospital Maggiore della Carità, Novara, Italy
Curr Neurol Neurosci Rep 10:327-32. 2010..The risk of suicidal ideation and behavior as side effects of AED treatment is low, and in people with epilepsy, such a risk must be balanced against the risk of not treating the seizures...
The pharmacological treatment of depression in adults with epilepsyMarco Mula
Amedeo Avogadro University, Department of Clinical and Experimental Medicine, Section of Neurology, Novara, Italy
Expert Opin Pharmacother 9:3159-68. 2008..Comorbid mood disorders may affect quality of life in people with epilepsy...
Antiepileptic drugs and psychopathology of epilepsy: an updateMarco Mula
Department of Neurology, Amedeo Avogadro University, Novara, Italy
Epileptic Disord 11:1-9. 2009..A previous history of psychiatric disorder or a familial predisposition are important risk factors and should be always considered when choosing the appropriate AED...
Paired-pulse flash-visual evoked potentials: new methods revive an old testRoberto Cantello
Department of Clinical and Experimental Medicine, Section of Neurology, University of Piedmont East A Avogadro, Novara, Italy
Clin Neurophysiol 122:1622-8. 2011..In the 1960s, methodological problems hindered this test, which was expected to provide important physiologic information...
Epilepsy and bipolar disordersMarco Mula
Department of Clinical and Experimental Medicine, Amedeo Avogadro University, Division of Neurology, University Hospital Maggiore della Carità, Corso Mazzini 18, 28100 Novara, Italy
Expert Rev Neurother 10:13-23. 2010..The present paper reviews available evidence regarding such an intriguing comorbidity in order to discuss valuable clinical issues and to suggest novel therapeutic strategies...
Pharmacokinetic Interactions between Antiepileptic and Antidepressant DrugsMarco Mula
Raymond Way Neuropsychiatry Research Group, Department of Clinical Neurology, Institute of Neurology, Queen Square, London, United Kingdom
World J Biol Psychiatry 4:21-4. 2003..In this paper, the available data about the mechanisms of metabolic kinetic interactions between antidepressant and antiepileptic drugs, as well as their clinical significance, has been reviewed...
Neuropharmacological aspects of cognitive neurorehabilitation in epilepsyMarco Mula
Department of Neurology, Amedeo Avogadro University, Novara, Italy
Behav Neurol 17:69-75. 2006..This paper reviews different pharmacological aspects of cognitive neurorehabilitation in epilepsy...
Antiepileptic-antipsychotic drug interactions: a critical review of the evidenceMarco Mula
Department of Neurology, Amedeo Avogadro University, Novara, Italy
Clin Neuropharmacol 25:280-9. 2002..In general, it is better to use as few drugs as possible, as multicolored politherapies increase the possible adverse effects of drug interactions and reduce patient compliance...
Complex pattern of convulsive syncope in glossopharyngeal neuralgia: video/EEG report and short reviewClaudia Varrasi
Department of Clinical and Experimental Medicine, Section of Neurology, University Piedmont East, Novara, Italy
Epilepsy Behav 20:407-9. 2011..Carbamazepine led to steady remission. Glossopharyngeal neuralgia is a rare condition (incidence of 0.7/100.000/year), whereas the occurrence of syncope is about 20%, and that of convulsive syncope is about 5%...
Recent and future antiepileptic drugs and their impact on cognition: what can we expect?Marco Mula
Division of Neurology, Amedeo Avogadro University, C so Mazzini, 18 28100 Novara, Italy
Expert Rev Neurother 12:667-71. 2012..Perampanel and ganaxolone are still in Phase III development, but the mechanism of action of these compounds is in line with a more sedative than neutral profile...
Antiepileptic drugs and suicidality: an expert consensus statement from the Task Force on Therapeutic Strategies of the ILAE Commission on NeuropsychobiologyMarco Mula
Amedeo Avogadro University, Novara, Italy
Epilepsia 54:199-203. 2013....
Obsessive-compulsive-spectrum symptoms in patients with focal dystonia, hemifacial spasm, and healthy subjectsMarco Mula
Department of Clinical and Experimental Medicine, A Avogadro University Division of Neurology, University Hospital, Maggiore della Carità, Novara, Italy
J Neuropsychiatry Clin Neurosci 24:81-6. 2012..Despite the different pathophysiology, OCD is highly represented in both FD and HFS, with different thematic content characterizing the two conditions...
New antiepileptic drugs: molecular targetsMarco Mula
Department of Clinical and Experimental Medicine, Section of Neurology, Amedeo Avogadro University, Corso Mazzini 18, Novara, Italy
Cent Nerv Syst Agents Med Chem 9:79-86. 2009..In this review the molecular targets for new AEDs are discussed, providing further suggestions on how future research can be improved...
Suicidality in people taking antiepileptic drugs: What is the evidence?Gail S Bell
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, and National Hospital for Neurology and Neurosurgery, UCL Hospitals NHS Foundation Trust, London, UK
CNS Drugs 23:281-92. 2009..In fact, the risk of stopping AEDs or refusing to start AEDs for the control of a seizure disorder may be significantly worse and may result in serious harm, including death of the patient...
Anticonvulsants - antidepressants pharmacokinetic drug interactions: the role of the CYP450 system in psychopharmacologyMarco Mula
Department of Clinical and Experimental Medicine, Section of Neurology, Amedeo Avogadro University, Novara, Italy
Curr Drug Metab 9:730-7. 2008..When prescribed with well-known inducers, the drug dose needs to be adjusted in relationship with the clinical response...
Ictal and peri-ictal psychopathologyMarco Mula
Department of Clinical and Experimental Medicine, Amedeo Avogadro University, Division of Neurology, University Hospital Maggiore della Carità, Novara, Italy
Behav Neurol 24:21-5. 2011..The present paper is aimed at reviewing major psychiatric symptoms that may occur around the ictus with special attention to clinical descriptions and relationships with interictal psychopathology...
Carbamazepine-risperidone interactions in patients with epilepsyMarco Mula
Department of Neurology, Amedeo Avogadro University, Novara, Italy
Clin Neuropharmacol 25:97-100. 2002..95 +/- 0.47 microg/mL (p < 0.0001) at T2. The pharmacokinetic data suggest either a possible role of RISP in inhibiting the cytochrome P450 microsomal enzyme system (CYP)-3A4 pathway or a potential role of CYP2D6 in CBZ metabolism...
Neuroanatomic correlates of psychogenic nonepileptic seizures: a cortical thickness and VBM studyAngelo Labate
Institute of Neurology, University Magna Graecia, Catanzaro, Italy
Epilepsia 53:377-85. 2012..Nonetheless, no advanced magnetic resonance imaging (MRI) studies have focused on patients with PNES...
Music and madness: neuropsychiatric aspects of musicMarco Mula
Department of Clinical and Experimental Medicine, Amedeo Avogadro University, Novara, Italy
Clin Med 9:83-6. 2009..This article is aimed at reviewing these complex relationships, starting from a wide perspective on the neurobiology of emotions, perceptions and music language to a detailed analysis of psychopathology in famous musicians...
Consciousness, epilepsy, and emotional qualiaFrancesco Monaco
Department of Neurology, Amedeo Avogadro University, Novara, Italy
Epilepsy Behav 7:150-60. 2005..Epilepsy is confirmed to represent a privileged window over basic neurobiological mechanisms of consciousness...
GABAergic drugs in the treatment of epilepsy: modern or outmoded?Marco Mula
Department of Clinical and Experimental Medicine, Division of Neurology, University Hospital Maggiore della Carità, Italy
Future Med Chem 3:177-82. 2011..All these compounds, although generally effective, are limited by their deleterious effects on cognition and behavior. The challenge will be to find GABAergic drugs that exhibit the beneficial effects, without the adverse ones...
Assessing suicidal risk with antiepileptic drugsMarco Mula
Department of Clinical and Experimental Medicine, Division of Neurology, Amedeo Avogadro University, University Hospital Maggiore della Carità, Novara, Italy
Neuropsychiatr Dis Treat 6:613-8. 2010....
Cesare Lombroso and epilepsy 100 years later: an unabridged report of his original transactionsFrancesco Monaco
Division of Neurology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University, University Hospital Maggiore della Carità, Novara, Italy
Epilepsia 52:679-88. 2011....
Depression in epilepsy: mechanisms and therapeutic approachMarco Mula
Department of Neurology, Amedeo Avogadro University, Novara, Italy
Ther Adv Neurol Disord 2:337-44. 2009..This paper is aimed at discussing all these subjects in the light of current literature on the neurobiology of depression in epilepsy...
Cluster-like headache and idiopathic intracranial hypertension: a case reportLucia Testa
Department of Neurology, Amedeo Avogadro University, Maggiore della Carita Hospital, Novara, Italy
J Headache Pain 9:181-3. 2008..In our opinion the asymmetrical presentation supports, in this case, the hypothesis of cavernous sinus involvement in the IIH-related cluster-like headache pathogenesis...
Re: Drug-induced psychosis with levetiracetamMarco Mula
Can J Psychiatry 50:948; author reply 948. 2005
Optimizing therapy of seizures in adult patients with psychiatric comorbidityEylert Brodtkorb
Department of Neurology and Clinical Neurophysiology, St Olav s Hospital, Trondheim University Hospital, 7006 Trondheim, Norway
Neurology 67:S39-44. 2006..Given the multitude of epilepsy treatment options with various CNS effects, it is crucial to select treatments according to the clinical profile of each individual patient...
Serotonin syndrome associated with tramadol-sertraline coadministrationDaniela Mittino
Clin Neuropharmacol 27:150-1. 2004
The global burden and stigma of epilepsyHanneke M de Boer
Epilepsy Institutes of The Netherlands Foundation SEIN, Heemstede, The Netherlands
Epilepsy Behav 12:540-6. 2008..Here we discuss some of the aspects of the global burden of epilepsy...
[Rating scales for the assessment of depersonalization symptoms: a review]Marco Mula
Epidemiol Psichiatr Soc 16:265-70. 2007
Can patients with epilepsy predict their seizures?Marco Mula
Neurology 69:494; author reply 494. 2007
