Marco Mula

..In this review the molecular targets for new AEDs are discussed, providing further suggestions on how future research can be improved...

..Further studies identifying specific behavioral endophenotypes may have practical implications in terms of prognosis and tailored treatment strategies...

..Finally, new formulations, especially those adopting drug targeting technologies are promising in order to maximize the efficacy with very limited adverse effects...

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..943 (CI95%=0.902-0.985; SE 0.021; p<0.001), a cut off score of 13, a sensitivity of 86.2%, a specificity of 89%, a positive predictive value of 71.4%, and a negative predictive value of 95.3%...

..Perampanel and ganaxolone are still in Phase III development, but the mechanism of action of these compounds is in line with a more sedative than neutral profile...

..Despite the different pathophysiology, OCD is highly represented in both FD and HFS, with different thematic content characterizing the two conditions...

..The present paper reviews available evidence regarding such an intriguing comorbidity in order to discuss valuable clinical issues and to suggest novel therapeutic strategies...

..A previous history of psychiatric disorder or a familial predisposition are important risk factors and should be always considered when choosing the appropriate AED...

..When prescribed with well-known inducers, the drug dose needs to be adjusted in relationship with the clinical response...

..This study aimed at investigating associations between HRQoL and comorbid mood and anxiety disorders...

..In this study, we sought to investigate their relationship with social and health-related QoL measures in patients with epilepsy...

..This study aimed at identifying clinical correlates of the IDD, with special attention to the relationship between symptoms and seizures...

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..Epileptologists need to be aware of the large and complex spectrum of bipolar symptoms in epilepsy to inform patients and their families, as well as to develop appropriate treatment strategies...

..All these compounds, although generally effective, are limited by their deleterious effects on cognition and behavior. The challenge will be to find GABAergic drugs that exhibit the beneficial effects, without the adverse ones...

..The present paper is aimed at reviewing major psychiatric symptoms that may occur around the ictus with special attention to clinical descriptions and relationships with interictal psychopathology...

..Continued clinical research is needed to obtain further knowledge about the optimal use of the expanding antiepileptic armamentarium and on how to tailor treatment to each individual patient according to clinical circumstances...

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..We sought to investigate whether IDD occurs only in patients with epilepsy and to validate IDD features against DSM-IV criteria...

..Alterations in the mesolimbic reward system could represent the putative neuropathological substrate for this multifaceted clinical picture...

..Schizotypal symptoms correlated with early onset of the seizures and a diagnosis of temporal lobe epilepsy, further confirming an association between psychoses and epilepsy...

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..This study aimed to investigate temperament and character correlates of panic disorder (PD) comorbidity in euthymic patients with bipolar disorder (BD) or unipolar depression (UD)...

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..To investigate the hypothesis that some patients with epilepsy are generally prone to develop psychiatric adverse events (PAEs) during antiepileptic drug (AED) therapy irrespective of the mechanism of action of the drugs...

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..It significantly discriminated subjects with any diagnosis of mood and anxiety disorders from controls and subjects with depersonalization disorder from controls. The hypothesized structure of the instrument was confirmed empirically...

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..Comorbid mood disorders may affect quality of life in people with epilepsy...

..The risk of suicidal ideation and behavior as side effects of AED treatment is low, and in people with epilepsy, such a risk must be balanced against the risk of not treating the seizures...

..Finally, the mood status of the patient and clinical relevance of the information obtained by neuropsychological testing represent important variables that need to be taken into account when discussing cognitive adverse effects of AEDs...

..In the 1960s, methodological problems hindered this test, which was expected to provide important physiologic information...

..Content of obsessive-compulsive themes focuses on sexuality and impulsiveness in Tourette syndrome and existential thoughts in temporal lobe epilepsy...

..This paper reviews different pharmacological aspects of cognitive neurorehabilitation in epilepsy...

..95 +/- 0.47 microg/mL (p < 0.0001) at T2. The pharmacokinetic data suggest either a possible role of RISP in inhibiting the cytochrome P450 microsomal enzyme system (CYP)-3A4 pathway or a potential role of CYP2D6 in CBZ metabolism...

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..On the other hand, the main factors that may affect choice of therapy, patients' response and compliance, when prescribing antidepressants or antipsychotic drugs, drug interactions and the potential proconvulsive risk are reviewed...

..In general, it is better to use as few drugs as possible, as multicolored politherapies increase the possible adverse effects of drug interactions and reduce patient compliance...

..Individuals with a personal or family history of depression should be carefully followed after initiation of therapy with a new antiepileptic drug, especially if structural brain abnormalities such as hippocampal sclerosis are present...

..Carbamazepine led to steady remission. Glossopharyngeal neuralgia is a rare condition (incidence of 0.7/100.000/year), whereas the occurrence of syncope is about 20%, and that of convulsive syncope is about 5%...

..In these patients, careful clinical monitoring is indicated, in selected cases, for potential seizure precipitation and side effects due to pharmacodynamics interactions...

..Further investigation is needed to determine in what circumstances they should be used in individuals who are partially responsive or nonresponsive to conventional therapy...

..Psychopathological characteristics of suicidal ideation were consistent in all subjects and similar to some features that are described as typical of the so-called interictal dysphoric disorder of epilepsy...

..This article explores the relationship between antiepileptic drugs and mania in patients with epilepsy, with special emphasis on the clinical pathophysiology of this phenomenon...

..This article is aimed at reviewing these complex relationships, starting from a wide perspective on the neurobiology of emotions, perceptions and music language to a detailed analysis of psychopathology in famous musicians...

..Epilepsy is confirmed to represent a privileged window over basic neurobiological mechanisms of consciousness...

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..This paper is aimed at discussing all these subjects in the light of current literature on the neurobiology of depression in epilepsy...

..In our opinion the asymmetrical presentation supports, in this case, the hypothesis of cavernous sinus involvement in the IIH-related cluster-like headache pathogenesis...

..By examining data from a large number of items covering the range of depressive symptoms, the aim of the present study is to contribute to the identification of the structure of depression on a lifetime perspective...

..The aim of the present study is to examine the structure of mania/hypomania using 68 items of the MOODS-SR that explore cognitive, mood and energy/activity features associated with mania/hypomania...