Dino Amadori

Summary

Affiliation: Morgagni-Pierantoni Hospital
Country: Italy

Publications

  1. ncbi request reprint Palliative care in advanced cancer
    D Amadori
    Istituto Scientifico Romagnolo per lo Studio e Cura dei Tumori IRST, Meldola, Italy
    Minerva Chir 60:205-16. 2005
  2. ncbi request reprint [Production and diffusion of scientific results in oncology]
    Dino Amadori
    Dipartimento Oncologico e dei Servizi di Diagnosi, Ospedale G B Morgagni L Pierantoni, Forli
    Ann Ist Super Sanita 40:357-62. 2004
  3. ncbi request reprint Secondary lung tumors in hematological patients
    Dino Amadori
    Division of Oncology and Diagnostics, Ospedale G B Morgagni, Forli, Italy
    Semin Respir Crit Care Med 26:520-6. 2005
  4. ncbi request reprint Phase III randomized multicenter study on the effects of adjuvant CMF in patients with node-negative, rapidly proliferating breast cancer: twelve-year results and retrospective subgroup analysis
    Dino Amadori
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Via Maroncelli 34 36, 47014 Meldola, Italy
    Breast Cancer Res Treat 108:259-64. 2008
  5. ncbi request reprint Prognosis in advanced cancer
    Marco Maltoni
    Oncology Department, Palliative Care Unit, Pierantoni Hospital, Via Forlanini, 34 47100 FORLI, Italy
    Hematol Oncol Clin North Am 16:715-29. 2002
  6. ncbi request reprint Tyrosine kinase inhibitors gefitinib, lapatinib and sorafenib induce rapid functional alterations in breast cancer cells
    Silvia Carloni
    Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori I R S T, 47014 Meldola, Italy
    Curr Cancer Drug Targets 10:422-31. 2010
  7. doi request reprint Low-dose taxotere enhances the ability of sorafenib to induce apoptosis in gastric cancer models
    Anna Tesei
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy
    J Cell Mol Med 15:316-26. 2011
  8. ncbi request reprint Iressa strengthens the cytotoxic effect of docetaxel in NSCLC models that harbor specific molecular characteristics
    Marco Rosetti
    Istituto Oncologico Romagnolo, Forli, Italy
    J Cell Physiol 212:710-6. 2007
  9. doi request reprint Role of conventional chemosensitivity test and tissue biomarker expression in predicting response to treatment of peritoneal carcinomatosis from colon cancer
    Chiara Arienti
    Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRST, Meldola, Italy
    Clin Colorectal Cancer 12:122-7. 2013
  10. doi request reprint Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines
    Paola Ulivi
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy
    J Cell Physiol 220:214-21. 2009

Detail Information

Publications88

  1. ncbi request reprint Palliative care in advanced cancer
    D Amadori
    Istituto Scientifico Romagnolo per lo Studio e Cura dei Tumori IRST, Meldola, Italy
    Minerva Chir 60:205-16. 2005
    ..In addition, assistance provided during the last hours of life and support for the family after the patient's death represent the so-called global assistance, which is distinctive of palliative care...
  2. ncbi request reprint [Production and diffusion of scientific results in oncology]
    Dino Amadori
    Dipartimento Oncologico e dei Servizi di Diagnosi, Ospedale G B Morgagni L Pierantoni, Forli
    Ann Ist Super Sanita 40:357-62. 2004
    ....
  3. ncbi request reprint Secondary lung tumors in hematological patients
    Dino Amadori
    Division of Oncology and Diagnostics, Ospedale G B Morgagni, Forli, Italy
    Semin Respir Crit Care Med 26:520-6. 2005
    ..This is confirmed by the identical RR (1.66) for CLL patients subjected to chemotherapy and for those who have only follow-up...
  4. ncbi request reprint Phase III randomized multicenter study on the effects of adjuvant CMF in patients with node-negative, rapidly proliferating breast cancer: twelve-year results and retrospective subgroup analysis
    Dino Amadori
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Via Maroncelli 34 36, 47014 Meldola, Italy
    Breast Cancer Res Treat 108:259-64. 2008
    ..We identified a subgroup of patients with intermediate proliferating tumors in whom the high benefit obtained from adjuvant CMF was maintained at a long-term follow up...
  5. ncbi request reprint Prognosis in advanced cancer
    Marco Maltoni
    Oncology Department, Palliative Care Unit, Pierantoni Hospital, Via Forlanini, 34 47100 FORLI, Italy
    Hematol Oncol Clin North Am 16:715-29. 2002
    ..Despite the usefulness of these instruments, however, the communication of a poor prognosis is one of the most difficult moments to face in the relationship between doctor and patient...
  6. ncbi request reprint Tyrosine kinase inhibitors gefitinib, lapatinib and sorafenib induce rapid functional alterations in breast cancer cells
    Silvia Carloni
    Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori I R S T, 47014 Meldola, Italy
    Curr Cancer Drug Targets 10:422-31. 2010
    ..These data suggest that the investigated drugs possess mechanisms of action that are independent of drug target expression, opening up further possibilities for the development of new therapeutic strategies...
  7. doi request reprint Low-dose taxotere enhances the ability of sorafenib to induce apoptosis in gastric cancer models
    Anna Tesei
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy
    J Cell Mol Med 15:316-26. 2011
    ..Our findings suggest the potential clinical usefulness of treatment with sorafenib and docetaxel for advanced gastric cancer...
  8. ncbi request reprint Iressa strengthens the cytotoxic effect of docetaxel in NSCLC models that harbor specific molecular characteristics
    Marco Rosetti
    Istituto Oncologico Romagnolo, Forli, Italy
    J Cell Physiol 212:710-6. 2007
    ....
  9. doi request reprint Role of conventional chemosensitivity test and tissue biomarker expression in predicting response to treatment of peritoneal carcinomatosis from colon cancer
    Chiara Arienti
    Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRST, Meldola, Italy
    Clin Colorectal Cancer 12:122-7. 2013
    ..In the present study, sensitivity and resistance to drugs used to treat PC were better defined by a conventional chemosensitivity test than by biomarker expression...
  10. doi request reprint Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines
    Paola Ulivi
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy
    J Cell Physiol 220:214-21. 2009
    ..Our results show that sorafenib exerts anti-proliferative and pro-apoptotic activity in pancreatic cancer cells. Used singly or in combination with other drugs, it could therefore represent valid treatment for pancreatic cancer...
  11. pmc Zoledronic acid increases docetaxel cytotoxicity through pMEK and Mcl-1 inhibition in a hormone-sensitive prostate carcinoma cell line
    Francesco Fabbri
    Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRST, Meldola, Italy
    J Transl Med 6:43. 2008
    ..In prostate cancer, the identification of drug combinations that could reduce the tumor cell population and rapidly eradicate hormone-resistant cells potentially present would be a remarkable breakthrough in the treatment of this disease...
  12. doi request reprint Role of efflux pump activity in lapatinib/caelyx combination in breast cancer cell lines
    Ivan Vannini
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola FC, Italy
    Anticancer Drugs 20:918-25. 2009
    ....
  13. doi request reprint Docetaxel-ST1481 sequence exerts a potent cytotoxic activity on hormone-resistant prostate cancer cells by reducing drug resistance-related gene expression
    Francesco Fabbri
    Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRST, Meldola, Italy
    Prostate 70:219-27. 2010
    ..The aims of the present work were to examine the in vitro activity and mechanisms of action of different antitumor drug combinations in hormone-resistant prostate cancer (HRPC) cell lines...
  14. ncbi request reprint Innovative sequence of docetaxel-gemcitabine based on preclinical data in the treatment of advanced non small cell lung cancer: a phase I study
    Toni Ibrahim
    Department of Medical Oncology, Pierantoni Hospital, Via Forlanini 34, 47100 Forli, Italy
    Lung Cancer 47:261-7. 2005
    ..Of the 14 evaluable patients, 1 complete response, 4 partial responses, 4 stable diseases and 5 disease progressions were observed. Based on the results of the present study, a phase II trial is ongoing using the fourth dose levels...
  15. doi request reprint Randomized phase III trial of adjuvant epirubicin followed by cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) versus CMF followed by epirubicin in patients with node-negative or 1-3 node-positive rapidly proliferating breast cancer
    Dino Amadori
    Cancer Institute of Romagna I R S T, Meldola, Italy
    Breast Cancer Res Treat 125:775-84. 2011
    ..Further molecular characterization of the tumors might help to identify subgroups achieving higher benefit from either sequence...
  16. ncbi request reprint HER-2 expression and cell proliferation: prognostic markers in patients with node-negative breast cancer
    Annalisa Volpi
    Dept of Medical Oncology, Pierantoni Hospital, Via Forlanini 34, 47100 Forli, Italy
    J Clin Oncol 21:2708-12. 2003
    ..We analyzed the clinical relevance of HER-2 expression, widely investigated in breast cancer but with contradictory results, in the largest case series of node-negative breast cancer patients investigated to date...
  17. pmc Phase II study of gemcitabine, doxorubicin and paclitaxel (GAT) as first-line chemotherapy for metastatic breast cancer: a translational research experience
    Alessandro Passardi
    Department of Medical Oncology, Morgagni Pierantoni Hospital, Forli, Italy
    BMC Cancer 6:76. 2006
    ..We aimed to evaluate the activity and toxicity of the GAT (gemcitabine, doxorubicin and paclitaxel) regimen, derived from experimental preclinical studies, as first-line chemotherapy in patients with stage IIIB-IV breast cancer...
  18. ncbi request reprint Molecular characterization of cytotoxic and resistance mechanisms induced by NCX 4040, a novel NO-NSAID, in pancreatic cancer cell lines
    Marco Rosetti
    Istituto Oncologico Romagnolo, Meldola, Italy
    Apoptosis 11:1321-30. 2006
    ..Moreover, the use of a specific COX-2 inhibitor (NS 398) in the experimental models showed that COX-2 hyperexpression could partially explain the resistance mechanisms to NCX 4040...
  19. pmc Addition of 5-fluorouracil to doxorubicin-paclitaxel sequence increases caspase-dependent apoptosis in breast cancer cell lines
    Wainer Zoli
    Division of Oncology and Diagnostics, Morgagni Pierantoni Hospital, Forli, Italy
    Breast Cancer Res 7:R681-9. 2005
    ....
  20. doi request reprint Pancreatic resection for metastases from renal cancer: long term outcome after surgery and immunotherapy approach - single center experience
    Andrea Gardini
    Department of Gastrointestinal and General Surgery, L Pierantoni Hospital, Forli, Italy
    Hepatogastroenterology 59:687-90. 2012
    ..The literature reports that selected patients may have benefits by pancreatic resection in terms of long term survival. We report patient outcome and considerations on immunotherapy approach...
  21. ncbi request reprint Short interfering RNA directed against the SLUG gene increases cell death induction in human melanoma cell lines exposed to cisplatin and fotemustine
    Ivan Vannini
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy
    Cell Oncol 29:279-87. 2007
    ..In this context, the SLUG gene has recently been characterized as a major regulator of melanocytes and melanoma cell survival...
  22. pmc Study of molecular mechanisms of pro-apoptotic activity of NCX 4040, a novel nitric oxide-releasing aspirin, in colon cancer cell lines
    Anna Tesei
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy
    J Transl Med 5:52. 2007
    ..In the present study, we investigated the mechanisms underlying the cytotoxicity of NCX 4040, a novel NO-aspirin with promising antineoplastic action, in in vitro human colon cancer models...
  23. doi request reprint Palliative sedation in end-of-life care and survival: a systematic review
    Marco Maltoni
    Istituto Scientifico Romagnolo per lo Studio e lCura dei Tumori, Meldola, Italy
    J Clin Oncol 30:1378-83. 2012
    ..We present a systematic review of literature on the clinical practice of palliative sedation to assess the effect, if any, on survival...
  24. doi request reprint Role of RANK, RANKL, OPG, and CXCR4 tissue markers in predicting bone metastases in breast cancer patients
    Toni Ibrahim
    Osteoncology Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy
    Clin Breast Cancer 11:369-75. 2011
    ..CXCR4 expression, alone or in combination with RANK, identified patients destined to relapse to bone...
  25. doi request reprint NCX 4040, an NO-donating acetylsalicylic acid derivative: efficacy and mechanisms of action in cancer cells
    Anna Tesei
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Via Maroncelli 40, 47014 Meldola, FC, Italy
    Nitric Oxide 19:225-36. 2008
    ..Moreover, the in vivo studies on xenografted mice further confirmed the antitumor efficacy and low toxicity of NCX 4040 in colon cancer and highlighted its role as sensitizing agent of oxaliplatin cytotoxicity...
  26. doi request reprint Bone metastases detection by circulating biomarkers: OPG and RANK-L
    Laura Mercatali
    Osteoncology Centre, Istituto Scientifico Romagnolo per Studio e Cura dei Tumori, Meldola, Italy
    Int J Oncol 39:255-61. 2011
    ..For VMP, OPG and RANK-L were expressed in only one patient. Our results highlight the potentially important role of circulating OPG in the diagnosis of bone metastases. A confirmatory study on a larger case series is ongoing...
  27. doi request reprint Activity of different anthracycline formulations in hormone-refractory prostate cancer cell lines: role of Golgi apparatus
    Francesco Fabbri
    Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy
    J Cell Physiol 226:3035-42. 2011
    ..Of note, the activity of NLPDX in taxane-resistant DU145-R cells warrants further evaluation as second-line treatment of advanced HRPC after taxane failure...
  28. doi request reprint The role of CXCR4 in the prediction of bone metastases from breast cancer: a pilot study
    Emanuele Sacanna
    Osteoncology Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy
    Oncology 80:225-31. 2011
    ..The aim of our retrospective case-control study was to evaluate whether CXCR4 expression is more effective than conventional markers (estrogen receptor and HER-2) in predicting bone relapse in breast cancer...
  29. ncbi request reprint Quantitative fluorescence determination of long-fragment DNA in stool as a marker for the early detection of colorectal cancer
    Daniele Calistri
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Via Maroncelli 40, Meldola FC, Italy
    Cell Oncol 31:11-7. 2009
    ..We aimed to validate the diagnostic accuracy, using the same threshold as in the previous pilot study, of fluorescent long DNA test as a relatively simple and inexpensive tool for colorectal cancer detection...
  30. doi request reprint Activity of lipoplatin in tumor and in normal cells in vitro
    Chiara Arienti
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, via P Maroncelli 40, Meldola, Italy
    Anticancer Drugs 19:983-90. 2008
    ..Moreover, ERCC1 and LRP expression levels would seem to be valid predictors of sensitivity or resistance to these drugs...
  31. doi request reprint A randomized phase II non-comparative study of pemetrexed‑carboplatin and gemcitabine‑vinorelbine in anthracycline- and taxane-pretreated advanced breast cancer patients
    Dino Amadori
    Romagnolo Scientific Institute for the Study and Treatment of Cancer, Meldola, Italy
    Int J Oncol 42:1778-85. 2013
    ..In this study, both combinations showed moderate activity as predefined RR was not reached and were well tolerated...
  32. ncbi request reprint Free DNA and carcinoembryonic antigen serum levels: an important combination for diagnosis of colorectal cancer
    Emanuela Flamini
    Department of Medical Oncology, Morgagni Pierantoni Hospital, Forli, Italy
    Clin Cancer Res 12:6985-8. 2006
    ..We compared the sensitivity and specificity of free circulating DNA with that of the more conventional carcinoembryonic antigen (CEA) and evaluated the two markers in combination...
  33. ncbi request reprint Schedule-dependent cytotoxic interaction between epidoxorubicin and gemcitabine in human bladder cancer cells in vitro
    Wainer Zoli
    Department of Medical Oncology, Pierantoni Hospital, Forli, Italy
    Clin Cancer Res 10:1500-7. 2004
    ..The aim of the study was to evaluate the activity of epidoxorubicin (EPI) and gemcitabine (GEM) and to define the most effective schedule in human bladder cancer cells...
  34. pmc Detection of colorectal cancer by a quantitative fluorescence determination of DNA amplification in stool
    Daniele Calistri
    Division of Oncology and Diagnostics, Pierantoni Hospital, Forli, Italy
    Neoplasia 6:536-40. 2004
    ....
  35. ncbi request reprint Mutation analysis of p53, K-ras, and BRAF genes in colorectal cancer progression
    Daniele Calistri
    Division of Oncology and Diagnostics, Morgagni Pierantoni Hospital, Forli, Italy
    J Cell Physiol 204:484-8. 2005
    ....
  36. doi request reprint A phase IB dose-finding trial of liposomal doxorubicin in combination with capecitabine in patients with pretreated metastatic breast cancer
    Andrea Rocca
    Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori I R S T, via P Maroncelli 40, 47014 Meldola, FC, Italy
    Cancer Chemother Pharmacol 65:871-6. 2010
    ..We conducted a dose-finding study of the combination of liposomal doxorubicin and capecitabine in patients with pretreated metastatic breast cancer...
  37. pmc Randomized phase II study with two gemcitabine- and docetaxel-based combinations as first-line chemotherapy for metastatic non-small cell lung cancer
    Alessandro Passardi
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy
    J Transl Med 6:65. 2008
    ..The aim of the present study was to evaluate and compare two treatment schedules, one based on our own preclinical data and the other selected from the literature...
  38. ncbi request reprint Urine telomerase activity for the detection of bladder cancer in females
    Sara Bravaccini
    Istituto Oncologico Romagnolo, Morgagni Pierantoni Hospital, Forli, Italy
    J Urol 178:57-61. 2007
    ....
  39. ncbi request reprint Relevance of urine telomerase in the diagnosis of bladder cancer
    Maria Aurora Sanchini
    Division of Oncology and Diagnostics, Morgagni Pierantoni Hospital, Forli, Italy
    JAMA 294:2052-6. 2005
    ....
  40. pmc Basic fibroblast growth factor and vascular endothelial growth factor serum levels in breast cancer patients and healthy women: useful as diagnostic tools?
    Anna Maria Granato
    Istituto Oncologico Romagnolo, Forli, Italy
    Breast Cancer Res 6:R38-45. 2004
    ..The study also evaluated the potential of serum levels of the two growth factors as diagnostic markers in a case-control study...
  41. ncbi request reprint Do serum angiogenic growth factors provide additional information to that of conventional markers in monitoring the course of metastatic breast cancer?
    Anna Maria Granato
    Istituto Oncologico Romagnolo, Forli, Italy
    Tumour Biol 27:302-8. 2006
    ....
  42. ncbi request reprint Multidisciplinary approach to the treatment of bone metastases: Osteo-Oncology Center, a new organizational model
    Toni Ibrahim
    Osteo Oncology Center, Istituto Romagnolo Scientifico per lo Studio e la Cura dei Tumori IRST, Meldola, Italy
    Tumori 95:291-7. 2009
    ....
  43. pmc Urine cell-free DNA integrity as a marker for early prostate cancer diagnosis: a pilot study
    Valentina Casadio
    IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRCCS IRST, via P Maroncelli 40, 47014 Meldola, Italy
    Biomed Res Int 2013:270457. 2013
    ..84 (95% CI 0.65-0.94). These preliminary findings indicate that UCF DNA integrity could be a promising noninvasive marker for the early diagnosis of prostate cancer and pave the way for further research into this area...
  44. doi request reprint Detection and recovery of circulating colon cancer cells using a dielectrophoresis-based device: KRAS mutation status in pure CTCs
    Francesco Fabbri
    Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRST, Meldola, Italy
    Cancer Lett 335:225-31. 2013
    ..Our results present dielectrophoresis-based procedures as a new standard in single cell analysis and recovery and invite careful reflection on the value of CTCs characterization...
  45. pmc Multiple marker detection in peripheral blood for NSCLC diagnosis
    Paola Ulivi
    Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy
    PLoS ONE 8:e57401. 2013
    ..We analyzed the diagnostic accuracy of a panel of peripheral blood markers in detecting non small cell lung cancer (NSCLC)...
  46. doi request reprint Prospective observational Italian study on palliative sedation in two hospice settings: differences in casemixes and clinical care
    Marco Maltoni
    Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRST, Meldola, Italy
    Support Care Cancer 20:2829-36. 2012
    ..We investigated PS for refractory symptoms in different hospice casemixes in order to (1) assess clinical decision-making, (2) monitor the practice of PS, and (3) examine the impact of PS on survival...
  47. doi request reprint Organosulfur derivatives of the HDAC inhibitor valproic acid sensitize human lung cancer cell lines to apoptosis and to cisplatin cytotoxicity
    Anna Tesei
    Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori I R S T, Meldola, Italy
    J Cell Physiol 227:3389-96. 2012
    ..Further studies are needed to confirm these preliminary findings...
  48. doi request reprint Time-dependent pharmacokinetics of 5-fluorouracil and association with treatment tolerability in the adjuvant setting of colorectal cancer
    Toni Ibrahim
    Osteoncology Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy
    J Clin Pharmacol 52:361-9. 2012
    ..These findings have safety implications for poor metabolizers whose drug clearance may fall below the threshold during repeated treatment cycles...
  49. pmc Survival prediction for terminally ill cancer patients: revision of the palliative prognostic score with incorporation of delirium
    Emanuela Scarpi
    Biostatistics and Clinical Trials Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy
    Oncologist 16:1793-9. 2011
    ..The PaP score assigns patients to three different risk groups according to a 30-day survival probability--group A, >70%; group B, 30%-70%; group C, <30%. The impact of delirium is known but was not incorporated into the PaP score...
  50. ncbi request reprint Prognostic relevance of histological grade and its components in node-negative breast cancer patients
    Annalisa Volpi
    Division of Oncology and Diagnostics, Pierantoni Hospital, Forli, Italy
    Mod Pathol 17:1038-44. 2004
    ....
  51. ncbi request reprint Accuracy of urine telomerase activity to detect bladder cancer in symptomatic patients
    Valentina Casadio
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola Forlì Cesena, Italy
    Int J Biol Markers 24:253-7. 2009
    ..Our results indicate that urine telomerase activity is a good marker for the early diagnosis of bladder tumors in symptomatic patients, a subset which represents an "at-risk" population requiring close surveillance...
  52. ncbi request reprint Immunosuppression in renal cancer: differential expression of signal transduction molecules in tumor-infiltrating, near-tumor tissue, and peripheral blood lymphocytes
    Angela Riccobon
    Department of Oncology, Pierantoni Hospital AUSL, Forli, Italy
    Cancer Invest 22:871-7. 2004
    ..10%; p=0.001). The absence or the very low expression of signaling activation molecules in TIL compared with NTTL and PBL in renal cancer patients suggest that tumor-induced immunosuppression generally occurs or starts locally...
  53. ncbi request reprint Cancer mortality in a cohort of male agricultural workers from northern Italy
    Lauro Bucchi
    Romagna Cancer Registry, Medical Oncology Department, Luigi Pierantoni Hospital, Forli, Italy
    J Occup Environ Med 46:249-56. 2004
    ..58 (1.34-1.86) in 1969-1976 to 0.97 (0.80-1.19) in 1985-1993. In conclusion, the only positive finding in this cohort of male agricultural workers was a generalized but declining excess mortality from gastric cancer...
  54. ncbi request reprint Prognostic relevance of mitotic activity in patients with node-negative breast cancer
    Laura Medri
    Pathology Unit, Division of Oncology and Diagnostics, Pierantoni Hospital, Forli, Italy
    Mod Pathol 16:1067-75. 2003
    ..The critical point remains the standardization of the preanalytical and analytical steps within quality control programs...
  55. doi request reprint Efficacy and safety of 12-weekly versus 4-weekly zoledronic acid for prolonged treatment of patients with bone metastases from breast cancer (ZOOM): a phase 3, open-label, randomised, non-inferiority trial
    Dino Amadori
    Osteoncology and Rare Tumors Center, IRCCS Scientific Institute of Romagna for the Study and Treatment of Cancer IRST IRCCS, Meldola, Italy
    Lancet Oncol 14:663-70. 2013
    ..We assessed the efficacy and safety of a reduced dosing frequency of zoledronic acid in women treated previously with monthly zoledronic acid...
  56. doi request reprint Metastatic bone disease in the era of bone-targeted therapy: clinical impact
    Toni Ibrahim
    Osteoncology and Rare Tumors Center, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRST, Meldola, Italy
    Tumori 99:1-9. 2013
    ..We therefore felt it would be useful to report on the epidemiological, clinical and economic impact of bone disease in a cancer setting...
  57. ncbi request reprint GEMOX plus tomotherapy for unresectable locally advanced pancreatic cancer
    Carlo Milandri
    Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori I R S T, Meldola, Italy
    Hepatogastroenterology 58:599-603. 2011
    ..The aim of this prospective phase II study was to evaluate the effect of neoadjuvant GEMOX plus helical tomotherapy on the resectability of locally advanced pancreatic cancer...
  58. ncbi request reprint Usefulness of immunological detection of the human telomerase reverse transcriptase
    Annalisa Volpi
    Division of Oncology, Morgagni Pierantoni Hospital, Forli, Italy
    Cell Oncol 27:347-53. 2005
    ..In situ analysis using well characterised antibodies directed against the human telomerase reverse transcriptase (hTERT) would therefore appear to be important to morphologically identify the nature of telomerase positive cells...
  59. doi request reprint Gene methylation in rectal cancer: predictive marker of response to chemoradiotherapy?
    Chiara Molinari
    Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRST, Meldola, Italy
    J Cell Physiol 228:2343-9. 2013
    ..Conversely, with the exception of TIMP3 gene, the methylation of selected genes does not seem to correlate with response to NCRT...
  60. pmc Inhibition of breast cancer cell proliferation in repeated and non-repeated treatment with zoledronic acid
    Toni Ibrahim
    Osteoncology Center, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRST, Via P, Maroncelli 40, 47014, Meldola, FC, Italy
    Cancer Cell Int 12:48. 2012
    ..abstract:..
  61. pmc Genomic alterations in rectal tumors and response to neoadjuvant chemoradiotherapy: an exploratory study
    Chiara Molinari
    Biosciences Laboratories, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy
    Radiat Oncol 6:161. 2011
    ..The present study aimed to define the genomic profile of rectal tumors and to identify alterations that are predictive of response in order to optimize therapeutic strategies...
  62. doi request reprint Ipilimumab in advanced melanoma: reports of long-lasting responses
    Alberto Farolfi
    Immunotherapy and Somatic Cell Therapy Unit bRadiology Unit, Cancer Institute of Romagna, Meldola, FC, Italy
    Melanoma Res 22:263-70. 2012
    ..Ipilimumab therapy resulted in clinically meaningful responses in advanced melanoma patients, supporting the need for further irRC validation...
  63. doi request reprint Managing chronic pain: results from an open-label study using MC5-A Calmare® device
    Marianna Ricci
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, via P Maroncelli 40, 47014 Meldola, FC, Italy
    Support Care Cancer 20:405-12. 2012
    ..We evaluated the effectiveness of an innovative neuromodulative approach to the treatment of chronic pain using electrical stimulus integrated with pharmacological support...
  64. doi request reprint Detection of HER2 and Topo 2 in breast cancers: comparison between MLPA and FISH approaches
    Sara Bravaccini
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori I R S T, Meldola, Italy
    J Clin Pathol 65:183-5. 2012
    ..In conclusion, MLPA is a fast and accurate quantitative method to detect HER2 and Topo 2 amplification, and could be considered a good alternative to FISH...
  65. pmc Urine telomerase: an important marker in the diagnosis of bladder cancer
    Maria Aurora Sanchini
    Division of Oncology and Diagnostics, Pierantoni Hospital, Forli, Italy
    Neoplasia 6:234-9. 2004
    ..In conclusion, this assay represents an important noninvasive diagnostic tool to detect bladder cancer also in patients with negative or nonassessable urine cytology and with low-grade and early-stage lesions...
  66. doi request reprint Assessment of EGFR and K-ras mutations in fixed and fresh specimens from transesophageal ultrasound-guided fine needle aspiration in non-small cell lung cancer patients
    Paola Ulivi
    Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy
    Int J Oncol 41:147-52. 2012
    ..K-ras mutations were detected in 8 (32%) fresh samples, and in 9 (36%) fixed cytological smears. Fixed and stained cytological samples seem to be more reliable than fresh material for molecular analysis...
  67. pmc Peritoneal carcinomatosis from ovarian cancer: chemosensitivity test and tissue markers as predictors of response to chemotherapy
    Chiara Arienti
    Biosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori I R S T, Meldola, Italy
    J Transl Med 9:94. 2011
    ....
  68. ncbi request reprint Impact of palliative care unit admission on symptom control evaluated by the edmonton symptom assessment system
    Caterina Modonesi
    Palliative Care Unit, Department of Medical Oncology, Forlimpopoli Hospital, Italy
    J Pain Symptom Manage 30:367-73. 2005
    ..0001), well-being (6.83-3.85, P < 0.0001), and dyspnea (7.08-3.86, P < 0.0001). These data seem to indicate that the patients who benefit most from inpatient palliative care are those with the most complex symptomatology...
  69. ncbi request reprint Results of a population-based screening for hereditary breast cancer in a region of North-Central Italy: contribution of BRCA1/2 germ-line mutations
    Ian J Seymour
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, FC, Italy
    Breast Cancer Res Treat 112:343-9. 2008
    ..This information shows that a correct and accurate clinical selection could avoid unnecessary molecular tests and could better address genetic analysis and clinical management...
  70. ncbi request reprint [Telomerase activity: a molecular marker for early diagnosis of bladder tumor]
    Daniele Calistri
    Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Forli
    Recenti Prog Med 98:74-8. 2007
    ..This test shows a high accuracy, mainly in males bladder tumor, and could be an important non invasive diagnostic tool for bladder cancer detection in high-risk groups screening programs...
  71. doi request reprint Normal-release oral morphine starting dose in cancer patients with pain
    Carla I Ripamonti
    Palliative Care Unit, IRCCS Foundation, National Cancer Institute, Milan, Italy
    Clin J Pain 25:386-90. 2009
    ..Secondary aims were to estimate the percentage of patients who were high responders to NRM and to study the association of baseline patient characteristics with both high analgesic responsivity and the need of opioid dose escalation...
  72. pmc FDG PET/CT Response Evaluation in Malignant Pleural Mesothelioma Patients Treated with Talc Pleurodesis and Chemotherapy
    Giovenzio Genestreti
    1 Department of Medical Oncology, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRST, Meldola, Italy
    J Cancer 3:241-5. 2012
    ..In our case series, the metabolic response measured by SUVmean seems to be in better agreement with the radiologic response compared to the SUVmax...
  73. ncbi request reprint Adjuvant immunotherapy with tumor infiltrating lymphocytes and interleukin-2 in patients with resected stage III and IV melanoma
    Laura Ridolfi
    Istituto Oncologico Romagnola, Pierantoni Hospital, Forli, Italy
    J Immunother 26:156-62. 2003
    ..Adoptive immunotherapy with TIL and IL-2 could improve DFS and OS, although further work is required to determine its role in the treatment of patients with high-risk melanoma...
  74. doi request reprint Osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: a retrospective study
    Toni Ibrahim
    Osteo oncology Center and Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Via Maroncelli 40, 47014 Meldola, Italy
    Oncologist 13:330-6. 2008
    ..Treatment includes bisphosphonates, which are also associated with avascular osteonecrosis of the jaw (ONJ). Our aim was to evaluate the correlation between bisphosphonates and ONJ...
  75. ncbi request reprint A validation study of the WHO analgesic ladder: a two-step vs three-step strategy
    Marco Maltoni
    Palliative Care Unit, Forlimpopoli Hospital, Via Duca d Aosta 33, 47034 Forlimpopoli FC, Italy
    Support Care Cancer 13:888-94. 2005
    ....
  76. ncbi request reprint Docetaxel followed by gemcitabine in the treatment of advanced non-small cell lung cancer: a phase I study
    Giovanni Luca Frassineti
    Department of Medical Oncology, Pierantoni Hospital, Forli, Italy
    Tumori 88:99-103. 2002
    ..Based on the results of a preclinical study, a phase I trial was conducted to evaluate the feasibility of administering docetaxel followed by gemcitabine in non-small cell lung cancer patients...
  77. ncbi request reprint NCX 4016, a nitric oxide-releasing aspirin derivative, exhibits a significant antiproliferative effect and alters cell cycle progression in human colon adenocarcinoma cell lines
    Anna Tesei
    Istituto Oncologico Romagnolo, Pierantoni Hospital, Forli, Italy
    Int J Oncol 22:1297-302. 2003
    ..Furthermore, the cytocidal effect observed at the highest concentrations and the induction of a specific block in G2 phase renders it a promising candidate for drug combination treatments...
  78. ncbi request reprint Gastric cancer mortality in the spouses of patients who died from gastric cancer
    Oriana Nanni
    Unit of Epidemiology and Medical Statistics, Istituto Oncologico Romagnolo, Forli, Italy
    Int J Epidemiol 31:468-72. 2002
    ....
  79. ncbi request reprint Fecal multiple molecular tests to detect colorectal cancer in stool
    Daniele Calistri
    Instituto Oncologico Romagnolo, Morgagni Hospital, Forli, Italy
    Clin Gastroenterol Hepatol 1:377-83. 2003
    ..We analyzed a large panel of molecular alterations involved in tumor transformation and progression to define their single diagnostic contribution in terms of sensitivity, cost, and time required to carry out the different tests...
  80. doi request reprint Clinical implications of microRNAs in lung cancer
    Francesca Fanini
    Gene Therapy Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy
    Semin Oncol 38:776-80. 2011
    ..This review focuses on these translational aspects of research on the field of miRNAs and lung cancer...
  81. doi request reprint Prolonged 18FDG-PET negative complete remission in a heavily pretreated, elderly patient with diffuse large B cell lymphoma treated with lenalidomide, low dose dexamethasone, and colony stimulating factor (Rd-G)
    Gerardo Musuraca
    Department of Hematology, Istituto Scientifico Romagnolo per Studio e Cura dei Tumori, Meldola, Italy
    Am J Hematol 86:79-80. 2011
    ..Several novel therapeutic approaches have been proposed for these patients including monoclonal antibodies, radioimmunotherapy, proteasome inhibitors, mTOR inhibitors, and the immunomodulatory drugs such as thalidomide and lenalidomide...
  82. ncbi request reprint Prospective, randomized study of single compared with double autologous stem-cell transplantation for multiple myeloma: Bologna 96 clinical study
    Michele Cavo
    Istituto di Ematologia ed Oncologia Medica Seràgnoli, Universita di Bologna, Bologn, Italy
    J Clin Oncol 25:2434-41. 2007
    ..We performed a prospective, randomized study of single (arm A) versus double (arm B) autologous stem-cell transplantation (ASCT) for younger patients with newly diagnosed multiple myeloma (MM)...
  83. doi request reprint Fludarabine and mitoxantrone followed by yttrium-90 ibritumomab tiuxetan in previously untreated patients with follicular non-Hodgkin lymphoma trial: a phase II non-randomised trial (FLUMIZ)
    Pier Luigi Zinzani
    Institute of Haematology and Medical Oncology L and A Seragnoli, University of Bologna, Bologna, Italy
    Lancet Oncol 9:352-8. 2008
    ....
  84. doi request reprint R-COMP 21 for frail elderly patients with aggressive B-cell non-Hodgkin lymphoma: a pilot study
    Giuseppe Visani
    Hematology and Hematopoietic Stem Cell Transplant Center, San Salvatore Hospital, Pesaro, Italy
    Leuk Lymphoma 49:1081-6. 2008
    ..In conclusion, R-COMP-21 is an effective regimen with promising response rates for frail and elderly patients with aggressive non-Hodgkin lymphoma...
  85. ncbi request reprint Melphalan-prednisone versus alternating combination VAD/MP or VND/MP as primary therapy for multiple myeloma: final analysis of a randomized clinical study
    Michele Cavo
    Institute of Hematology and Medical Oncology Seragnoli, Via Massarenti 9, 40138 Bologna, Italy
    Haematologica 87:934-42. 2002
    ....
  86. ncbi request reprint Low dose gemtuzumab ozogamicin for relapsed acute myeloid leukaemia in elderly
    Pier Paolo Piccaluga
    Institute of Haematology and Medical Oncology L and A Seragnoli, S Orsola Malpighi Hospital, University of Bologna, Italy
    Haematologica 88:ECR37. 2003
  87. ncbi request reprint Persistence of chromosomal abnormalities additional to the Philadelphia chromosome after Philadelphia chromosome disappearance during imatinib therapy for chronic myeloid leukemia
    Alfonso Zaccaria
    Haematologica 92:564-5. 2007
    ..This finding is consistent with a secondary origin of the Ph chromosome in these patients. It is still to early to evaluate the possible prognostic value of these additional abnormalities...
  88. ncbi request reprint Osteonecrosis of the jaws in newly diagnosed multiple myeloma patients treated with zoledronic acid and thalidomide-dexamethasone
    Patrizia Tosi
    Blood 108:3951-2. 2006