Rodolfo Montironi

Summary

Country: Italy

Publications

  1. ncbi request reprint Update on selected renal cell tumors with clear cell features. With emphasis on multilocular cystic clear cell renal cell carcinoma
    R Montironi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Histol Histopathol 28:1555-66. 2013
  2. pmc Immunohistochemical analysis of chromatin remodeler DAXX in high grade urothelial carcinoma
    Antonio Zizzi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, 60126, Torrette Ancona, Italy
    Diagn Pathol 8:111. 2013
  3. doi request reprint A randomized phase IIb presurgical study of finasteride vs. low-dose flutamide vs. placebo in men with prostate cancer. Efficacy monitored by karyometry
    Rodolfo Montironi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Urol Oncol 31:557-65. 2013
  4. ncbi request reprint Classification and grading of noninvasive and invasive neoplasms of the urothelium
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Anal Quant Cytol Histol 34:111-9. 2012
  5. doi request reprint The spectrum of morphology in non-neoplastic prostate including cancer mimics
    Rodolfo Montironi
    Section of Pathological Anatomy, Polytechnic University of Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Histopathology 60:41-58. 2012
  6. ncbi request reprint Karyometry detects subvisual differences in chromatin organization state between cribriform and flat high-grade prostatic intraepithelial neoplasia
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, Ancona, Italy
    Mod Pathol 17:928-37. 2004
  7. ncbi request reprint Morphological diagnosis of urothelial neoplasms
    R Montironi
    Section of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region Ancona, Ancona, Italy
    J Clin Pathol 61:3-10. 2008
  8. ncbi request reprint Carcinoma of the prostate: inherited susceptibility, somatic gene defects and androgen receptors
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region Ancona, School of Medicine, Azienda Ospedaliera Umberto I, 60020 Torrette, Ancona, Italy
    Virchows Arch 444:503-8. 2004
  9. ncbi request reprint Target populations, pathological biomarkers and chemopreventive agents in prostate cancer prevention
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, University of Ancona, Ancona, Italy
    Arch Ital Urol Androl 75:127-34. 2003
  10. ncbi request reprint Handling and pathology reporting of radical prostatectomy specimens
    Rodolfo Montironi
    Institute of Pathological Anatomy, Polytechnic University of the Marche Region Ancona, Umberto 1 degrees Hospital, I 60020 Torrette, Ancona, Italy
    Eur Urol 44:626-36. 2003

Detail Information

Publications157 found, 100 shown here

  1. ncbi request reprint Update on selected renal cell tumors with clear cell features. With emphasis on multilocular cystic clear cell renal cell carcinoma
    R Montironi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Histol Histopathol 28:1555-66. 2013
    ..In conclusion, recognition of CCRCC and differentiation from other renal cell neoplasms with clear cytoplasm is important not only for prognostication but also for treatment-related reasons. ..
  2. pmc Immunohistochemical analysis of chromatin remodeler DAXX in high grade urothelial carcinoma
    Antonio Zizzi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, 60126, Torrette Ancona, Italy
    Diagn Pathol 8:111. 2013
    ..The aim of this exploratory immunohistochemical study was to evaluate DAXX protein expression in high grade invasive urothelial carcinoma (UC) of the bladder as a biological regulator of aggressiveness...
  3. doi request reprint A randomized phase IIb presurgical study of finasteride vs. low-dose flutamide vs. placebo in men with prostate cancer. Efficacy monitored by karyometry
    Rodolfo Montironi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Urol Oncol 31:557-65. 2013
    ..The aim of the study was to explore karyometry as a method for monitoring the efficacy of intervention with preventive agents in patients with CaP...
  4. ncbi request reprint Classification and grading of noninvasive and invasive neoplasms of the urothelium
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Anal Quant Cytol Histol 34:111-9. 2012
    ..However, some controversies on the precise criteria and terminology, especially when the papillary lesions are concerned, are still present...
  5. doi request reprint The spectrum of morphology in non-neoplastic prostate including cancer mimics
    Rodolfo Montironi
    Section of Pathological Anatomy, Polytechnic University of Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Histopathology 60:41-58. 2012
    ..Diagnostic awareness of the salient histomorphological and relevant immunohistochemical features of these prostatic pseudoneoplasms is critical to avoid rendering false positive diagnoses of malignancy...
  6. ncbi request reprint Karyometry detects subvisual differences in chromatin organization state between cribriform and flat high-grade prostatic intraepithelial neoplasia
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, Ancona, Italy
    Mod Pathol 17:928-37. 2004
    ....
  7. ncbi request reprint Morphological diagnosis of urothelial neoplasms
    R Montironi
    Section of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region Ancona, Ancona, Italy
    J Clin Pathol 61:3-10. 2008
    ..The WHO 2004 classification is currently used. However, the WHO 1973 classification is still considered by many urologists and oncologists as the international standard in patient management...
  8. ncbi request reprint Carcinoma of the prostate: inherited susceptibility, somatic gene defects and androgen receptors
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region Ancona, School of Medicine, Azienda Ospedaliera Umberto I, 60020 Torrette, Ancona, Italy
    Virchows Arch 444:503-8. 2004
    ..The identification of key molecular alteration cells implicates carcinogen defenses, including GSTP1, growth factor signaling pathways (such as PTEN and p27) and androgens as critical determinants of the phenotype of PCa...
  9. ncbi request reprint Target populations, pathological biomarkers and chemopreventive agents in prostate cancer prevention
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, University of Ancona, Ancona, Italy
    Arch Ital Urol Androl 75:127-34. 2003
    ..Histopathologists play an important role in prostate chemoprevention. In fact, they define the high-risk groups, recognise the surrogate end markers and evaluate the morphological effects of the agents on the prostate tissue specimens...
  10. ncbi request reprint Handling and pathology reporting of radical prostatectomy specimens
    Rodolfo Montironi
    Institute of Pathological Anatomy, Polytechnic University of the Marche Region Ancona, Umberto 1 degrees Hospital, I 60020 Torrette, Ancona, Italy
    Eur Urol 44:626-36. 2003
    ..The pathology report should include relevant clinical information as well as provide prognostically useful data derived from the evaluation of the RP specimen...
  11. ncbi request reprint Molecular techniques and prostate cancer diagnostic
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, School of Medicine, Polytechnic University of the Marche Region Ancona, Azienda Ospedaliera Umberto I degrees, I 60020, Ancona, Torrette, Italy
    Eur Urol 44:390-400. 2003
    ..In this review several recently developed molecular techniques are described and illustrated. The focus is on prostate cancer diagnostics, as an example of their application...
  12. doi request reprint Morphological classification and definition of benign, preneoplastic and non-invasive neoplastic lesions of the urinary bladder
    R Montironi
    School of Medicine, Polytechnic University of the Marche Region, United Hospitals, Ancona, Italy
    Histopathology 53:621-33. 2008
    ..There is still debate in the literature as to whether the 2004 WHO system should be the only one to be used and whether the 1973 WHO system should be abandoned...
  13. ncbi request reprint Cystic nephroma and mixed epithelial and stromal tumour of the kidney: opposite ends of the spectrum of the same entity?
    Rodolfo Montironi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Eur Urol 54:1237-46. 2008
    ..Our aim was to review the broad spectrum of usual and unusual clinical and morphologic findings observed in CN and MEST...
  14. ncbi request reprint HER2 expression and gene amplification in pT2a Gleason score 6 prostate cancer incidentally detected in cystoprostatectomies: comparison with clinically detected androgen-dependent and androgen-independent cancer
    Rodolfo Montironi
    Section of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, School of Medicine, I 60020 Torrette, Ancona, Italy
    Hum Pathol 37:1137-44. 2006
    ..This may contribute to a better understanding of the results obtained in screening programs where insignificant cancers are detected along with clinically significant cancers...
  15. ncbi request reprint Chromatin phenotype karyometry can predict recurrence in papillary urothelial neoplasms of low malignant potential
    Rodolfo Montironi
    Section of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, Ancona, Italy
    Cell Oncol 29:47-58. 2007
    ..Pathol. 57(2004), 1201-1207) had shown that a karyometric assessment of nuclei from papillary urothelial neoplasms of low malignant potential (PUNLMP) revealed subtle differences in phenotype which correlated with recurrence of disease...
  16. ncbi request reprint Immunohistochemical expression of endothelin-1 and endothelin-A and endothelin-B receptors in high-grade prostatic intraepithelial neoplasia and prostate cancer
    Rodolfo Montironi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, Ancona, Italy
    Eur Urol 52:1682-9. 2007
    ..High-grade prostatic intraepithelial neoplasia (HGPIN) was also investigated...
  17. ncbi request reprint Prostate carcinoma I: prognostic factors in radical prostatectomy specimens and pelvic lymph nodes
    Rodolfo Montironi
    Department of Pathology, Reina Sofia University Hospital and Cordoba University Medical School, Cordoba, Spain
    BJU Int 97:485-91. 2006
  18. ncbi request reprint Prostate carcinoma II: prognostic factors in prostate needle biopsies
    Rodolfo Montironi
    Department of Pathology, Reina Sofia University Hospital and Cordoba University Medical School, Cordoba, Spain
    BJU Int 97:492-7. 2006
  19. ncbi request reprint 2005 update on pathology of prostate biopsies with cancer
    Rodolfo Montironi
    Pathology, Polytechnic University, Ancona, Italy
    Eur Urol 49:441-7. 2006
    ..To review the diagnostic and prognostic importance of pathologic findings in prostate biopsies...
  20. ncbi request reprint Histopathology reporting of prostate needle biopsies. 2005 update
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region Ancona, School of Medicine, United Hospitals, Via Conca 71, 60020 Torrette, Ancona, Italy
    Virchows Arch 449:1-13. 2006
    ....
  21. ncbi request reprint Atypical foci suspicious but not diagnostic of malignancy in prostate needle biopsies (also referred to as "atypical small acinar proliferation suspicious for but not diagnostic of malignancy")
    Rodolfo Montironi
    Pathology, Marche Polytechnic University, Ancona, Italy
    Eur Urol 50:666-74. 2006
    ..To review atypical focus suspicious but not diagnostic of malignancy in needle biopsies of the prostate, also referred to as "atypical small acinar proliferation suspicious for but not diagnostic of malignancy."..
  22. ncbi request reprint HER-2 expression and gene amplification in high-grade PIN and prostate cancer
    Rodolfo Montironi
    Section of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, School of Medicine, Ancona, Italy
    Arch Ital Urol Androl 78:135-9. 2006
    ..5%). A statistically significant difference in the number of cases with both overexpression and amplification was only seen between CyP and hormone-independent cancers (p = 0.007)...
  23. ncbi request reprint Incidentally detected prostate cancer in cystoprostatectomies: pathological and morphometric comparison with clinically detected cancer in totally embedded specimens
    Rodolfo Montironi
    Polytechnic University of the Marche Region, School of Medicine, Umberto I Hospital, Torrette, Ancona, Italy
    Hum Pathol 36:646-54. 2005
    ..We conclude that incidentally detected cancer is less aggressive than clinically detected cancer...
  24. ncbi request reprint Gleason grading of prostate cancer in needle biopsies or radical prostatectomy specimens: contemporary approach, current clinical significance and sources of pathology discrepancies
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, Ancona, Italy
    BJU Int 95:1146-52. 2005
    ..However, there are significant deficiencies in the practice of this grading system. Not only are there problems among practising pathologists but also a relative lack of interobserver reproducibility among experts...
  25. pmc Basal cell hyperplasia and basal cell carcinoma of the prostate: a comprehensive review and discussion of a case with c-erbB-2 expression
    R Montironi
    Section of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, School of Medicine, Azienda Ospedaliera Umberto I, Via Conca 71, I 60020 Torrette, Ancona, Italy
    J Clin Pathol 58:290-6. 2005
    ..In general, basal cell carcinoma is seen as a low grade carcinoma. The immunohistochemical expression of the c-erbB-2 oncoprotein, similar to that seen in breast cancer, might have therapeutic importance...
  26. ncbi request reprint Bayesian belief network for the Gleason patterns in prostatic adenocarcinoma: development of a diagnostic decision support system for educational purposes
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, Torrette, Ancona, Italy
    Anal Quant Cytol Histol 30:8-15. 2008
    ..To develop a Bayesian belief network (BBN) for Gleason grading of prostate adenocarcinoma...
  27. ncbi request reprint Immunohistochemical detection and localization of somatostatin receptor subtypes in prostate tissue from patients with bladder outlet obstruction
    Rodolfo Montironi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Cell Oncol 30:473-82. 2008
    ..6% of the endothelial cells. With subtypes 3 and 4 the greatest proportion of cells showed a weak intensity (73.5 and 56.4%, respectively). With the subtype 2 and 5 the majority of cells were negative (59.1 and 50.7%, respectively)...
  28. pmc How much do you know about benign, preneoplastic, non-invasive and invasive neoplastic lesions of the urinary bladder classified according to the 2004 WHO scheme?
    Rodolfo Montironi
    Section of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region Ancona, Ancona, Italy
    Diagn Pathol 6:31. 2011
    ..This paper is directed to all who are involved with the application of this classification at the anticancer research, diagnostic, prognostic and therapeutic levels, in particular to uropathologists, urologists and oncologists...
  29. doi request reprint Role of histopathology and molecular markers in the active surveillance of prostate cancer
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, School of Medicine, Polytechnic University of the Marche Region, United Hospitals, Via Conca 71, Torrette, Ancona, Italy
    Acta Oncol 50:56-60. 2011
    ....
  30. ncbi request reprint Mechanisms of disease: high-grade prostatic intraepithelial neoplasia and other proposed preneoplastic lesions in the prostate
    Rodolfo Montironi
    Uropathology Section, Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region Ancona, School of Medicine, United Hospitals, Torrette, Ancona, Italy
    Nat Clin Pract Urol 4:321-32. 2007
    ....
  31. doi request reprint Prostatic intraepithelial neoplasia: its morphological and molecular diagnosis and clinical significance
    Rodolfo Montironi
    Institute of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region Ancona, United Hospitals, Ancona, Italy
    BJU Int 108:1394-401. 2011
    ..Some recent studies have suggested that molecular findings associated with HGPIN might be able to predict which men are more likely to have cancer on re-biopsy...
  32. doi request reprint Decision support systems for morphology-based diagnosis and prognosis of prostate neoplasms: a methodological approach
    Rodolfo Montironi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Cancer 115:3068-77. 2009
    ..This has had a significant impact on our capability to derive diagnostic and prognostic information from histopathological material with prostate neoplasms. Cancer 2009;115(13 suppl):3068-77. (c) 2009 American Cancer Society...
  33. ncbi request reprint alpha-Methylacyl coenzyme A racemase, Ki-67, and topoisomerase IIalpha in cystoprostatectomies with incidental prostate cancer
    Alfredo Santinelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Am J Clin Pathol 128:657-66. 2007
    ..Our findings in marker expression in NEp, atrophy, and HPIN suggest that there are some differences in the field effects in terms of prostatic carcinogenesis between CyP and RP specimens...
  34. doi request reprint Immunohistochemical expression of prostate tumour overexpressed 1 (PTOV1) in atypical adenomatous hyperplasia (AAH) of the prostate: additional evidence linking (AAH) to adenocarcinoma
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Torrette, Ancona, Italy
    Cell Oncol (Dordr) 36:37-42. 2013
    ..It has been suggested that overexpression of PTOV1 can contribute to the proliferative status of prostate tumour cells and thus to their biological behaviour...
  35. doi request reprint Prediction of prostatic involvement by urothelial carcinoma in radical cystoprostatectomy for bladder cancer
    Roberta Mazzucchelli
    Polytechnic University of the Marche Region School of Medicine, United Hospitals, Ancona, Italy
    Urology 74:385-90. 2009
    ..To ascertain which variables of bladder urothelial carcinoma (UC) might be useful in predicting either UC involving the prostate (UCP) or incidental prostate adenocarcinoma in radical cystoprostatectomy specimens...
  36. doi request reprint Immunohistochemical expression of somatostatin receptor subtypes in prostate tissue from cystoprostatectomies with incidental prostate cancer
    Doriana Morichetti
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    BJU Int 106:1072-80. 2010
    ..To examine immunohistochemically the expression of the five somatostatin receptors (SSTRs) in cystoprostatectomies (CyPs) with incidental prostate cancer...
  37. ncbi request reprint Strong immunohistochemical expression of fibroblast growth factor receptor 3, superficial staining pattern of cytokeratin 20, and low proliferative activity define those papillary urothelial neoplasms of low malignant potential that do not recur
    Francesca Barbisan
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Cancer 112:636-44. 2008
    ..The objective of the current study was to evaluate immunohistochemically tissue expression of fibroblast growth factor receptor 3 (FGFR3), cytokeratin 20 (CK20), and MIB-1 in nonrecurrent and recurrent PUNLMP...
  38. doi request reprint Immunohistochemical expression of prostate tumor overexpressed 1 in cystoprostatectomies with incidental and insignificant prostate cancer. Further evidence for field effect in prostatic carcinogenesis
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, 60126 Ancona, Italy
    Hum Pathol 42:1931-6. 2011
    ....
  39. ncbi request reprint Subvisual changes in chromatin organization state are detected by karyometry in the histologically normal urothelium in patients with synchronous papillary carcinoma
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, University of Ancona School of Medicine, Torrette, Italy
    Hum Pathol 34:893-901. 2003
    ..In conclusion, karyometry can detect an abnormal chromatin pattern and distribution in the normal-looking urothelium adjacent to papillary carcinoma. Such alterations correspond to the so-called "malignancy-associated change."..
  40. doi request reprint Immunohistochemical expression and localization of somatostatin receptor subtypes in androgen ablated prostate cancer
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Torrette, Ancona, Italy
    Cell Oncol (Dordr) 34:235-43. 2011
    ....
  41. pmc Search for residual prostate cancer on pT0 radical prostatectomy after positive biopsy
    Roberta Mazzucchelli
    Section of Pathological Anatomy and Histopathology, School of Medicine, United Hospitals, Polytechnic University of the Marche Region Ancona, I 60020 Torrette, Ancona, Italy
    Virchows Arch 450:371-8. 2007
    ..If a block is missing part of the peripheral zone (capsular incision), this should be commented on. DNA analysis for tissue identity should be performed when the other steps have been taken without finding cancer...
  42. ncbi request reprint Chromosomal abnormalities in macroscopically normal urothelium in patients with bladder pT1 and pT2a urothelial carcinoma: a fluorescence in situ hybridization study and correlation with histologic features
    Roberta Mazzucchelli
    Section of Pathological Anatomy and Histopathology, School of Medicine, Polytechnic University of the Marche Region Ancona, Ancona, Italy
    Anal Quant Cytol Histol 27:143-51. 2005
    ..To analyze chromosomal abnormalities in macroscopically normal urothelium in patients with bladder pT1 and pT2a urothelial carcinoma and correlate the changes with histologic features...
  43. doi request reprint Overexpression of ELAV-like protein HuR is associated with increased COX-2 expression in atrophy, high-grade prostatic intraepithelial neoplasia, and incidental prostate cancer in cystoprostatectomies
    Francesca Barbisan
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Eur Urol 56:105-12. 2009
    ..The human ELAV-like protein HuR regulates the stability of several mRNA targets, including that of cyclooygenase-2 (COX-2). Their expression in prostatic carcinogenesis is uncertain...
  44. doi request reprint Is incidentally detected prostate cancer in patients undergoing radical cystoprostatectomy clinically significant?
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Am J Clin Pathol 131:279-83. 2009
    ..5 cc, 116 (94.3%). Of the 123 incidentally detected cases of PCa, 100 (81.3%) were considered clinically insignificant. Incidentally detected PCa is frequently observed in RCP. The majority are clinically insignificant...
  45. doi request reprint Urothelial and incidental prostate carcinoma in prostates from cystoprostatectomies for bladder cancer: is there a relationship between urothelial and prostate cancer?
    Francesca Barbisan
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    BJU Int 103:1058-63. 2009
    ..To determine the incidence and features of urothelial carcinoma (UC) involving the prostate (UCP) and of prostate adenocarcinoma (PA) in radical cystoprostatectomy (RCP) for bladder cancer...
  46. doi request reprint Cyclin D3 gene amplification in bladder carcinoma in situ
    Antonio Lopez-Beltran
    Department of Pathology, Cordoba University Medical School, Spain
    Virchows Arch 457:555-61. 2010
    ..06 (95% (confidence interval (CI)), 15.5-23.6); mean progression (months) occurred at 23.8 ± 1.46 (95% (CI), 20.9-26.7). Our study suggests that Cyclin D3 gene amplification might be a predictor of aggressiveness in BCG-treated CIS...
  47. pmc Somatostatin receptor subtypes in hormone-refractory (castration-resistant) prostatic carcinoma
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona 60126, Italy
    Asian J Androl 13:242-7. 2011
    ..In conclusion, this study expands our knowledge on the expression and localisation of five SSTRs in the various tissue components in the HR PCa compared with hormone-sensitive PCa...
  48. doi request reprint Immunohistochemical expression and localization of somatostatin receptor subtypes in androgen ablated prostate cancer
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Anal Cell Pathol (Amst) 33:27-36. 2010
    ....
  49. ncbi request reprint Clinical pathology of prostate cancer: focus on diagnosis, predictive and prognostic factors and quality indicators
    Andrea B Galosi
    Institute of Urology, Universita Politecnica delle Marche, Azienda Ospedaliero Universitaria Ospedali Riuniti, Ancona, Italy
    Arch Ital Urol Androl 79:45-51. 2007
    ..Nowadays more and detailed information is available from the pathologic analysis of the prostatic biopsies and surgical samples in patients with prostate carcinoma...
  50. ncbi request reprint Comparison of proliferating cell nuclear antigen immunostaining in lymph node metastases and primary prostate adenocarcinoma after neoadjuvant androgen deprivation therapy
    Daniele Minardi
    Institute of Urology, University of Ancona Medical School, Ancona, Italy
    Scand J Urol Nephrol 38:19-25. 2004
    ..To evaluate the effect of neoadjuvant androgen deprivation therapy (NADT) on the cellular proliferative activity in primary prostate cancer and lymph node metastases using proliferating cell nuclear antigen (PCNA) immunostaining...
  51. ncbi request reprint Prognostic value of CD44 expression in penile squamous cell carcinoma: a pilot study
    Daniele Minardi
    Institute of Maternal and Children s Sciences, Urology, Polytechnic University of the Marches Region, Azienda Ospedaliero Universitaria Ospedali Riuniti, Ancona, Italy
    Cell Oncol (Dordr) 35:377-84. 2012
    ..Our aim was to determine whether CD44 expression may serve as a prognostic marker for lymph node metastasis and survival in penile SCC patients...
  52. doi request reprint Rare and unusual histological variants of prostatic carcinoma: clinical significance
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    BJU Int 102:1369-74. 2008
    ..They are usually aggressive tumours that often present with secondary deposits. The outcome is generally poor. Only basal cell carcinoma is seen as a low-grade carcinoma...
  53. ncbi request reprint Atypical adenomatous hyperplasia (adenosis) of the prostate: DNA ploidy analysis and immunophenotype
    Antonio Lopez-Beltran
    Department of Pathology, Cordoba University Medical School, Cordoba, Spain
    Int J Surg Pathol 13:167-73. 2005
    ..105) or carcinoma (p=0.0820). All foci of nodular hyperplasia, AAH, and carcinoma were diploid. Ploidy status and our selected panel of antibodies did not discriminate among these 3 entities reliably...
  54. pmc Squamous differentiation in primary urothelial carcinoma of the urinary tract as seen by MAC387 immunohistochemistry
    Antonio Lopez-Beltran
    Unit of Anatomic Pathology, Cordoba University Medical School and Reina Sofia University Hospital, Cordoba, Spain
    J Clin Pathol 60:332-5. 2007
    ..027) and increases with grade/stage mainly in bladder carcinoma (grade, p = 0.05; stage, p = 0.005). Stage Ta/T1 bladder carcinomas with SqD recurred more (p = 0.021). In conclusion, Mac387 efficiently shows SqD in urothelial tumours...
  55. ncbi request reprint Urothelial dysplasia of the bladder: diagnostic features and clinical significance
    Antonio Lopez-Beltran
    Department of Surgery and Pathology, Cordoba University Medical School, Cordoba, Spain
    Anal Quant Cytol Histol 35:121-9. 2013
    ..We present pathologic features and clinical significance of urothelial dysplasia with emphasis on differential diagnosis from common flat urothelial lesions with atypia...
  56. ncbi request reprint Epidermal growth factor receptor protein expression and gene amplification in small cell carcinoma of the urinary bladder
    Xiaoyan Wang
    Department of Pathology, Indiana University, Indianapolis, Indiana 46202, USA, and United Hospitals, Ancona, Italy
    Clin Cancer Res 13:953-7. 2007
    ..This study was done to investigate EGFR protein expression and gene amplification in a large series of small cell carcinomas of the urinary bladder...
  57. doi request reprint Handling and reporting of transurethral resection specimens of the bladder in Europe: a web-based survey by the European Network of Uropathology (ENUP)
    Antonio Lopez-Beltran
    Unit of Anatomic Pathology, Cordoba University Medical School, Cordoba, Spain
    Histopathology 58:579-85. 2011
    ..To collect of information about European practices on handling and reporting of transurethral resection specimens of the bladder...
  58. ncbi request reprint Pathology of prostate cancer and focal therapy ('male lumpectomy')
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, I 60 126 Torrette, Ancona, Italy
    Anticancer Res 29:5155-61. 2009
    ....
  59. doi request reprint Expression of prostate stem cell antigen in high-grade prostatic intraepithelial neoplasia and prostate cancer
    Francesca Barbisan
    Section of Pathological Anatomy, United Hospitals and Polytechnic University of the Marche Region, School of Medicine, Ancona, Italy
    Histopathology 57:572-9. 2010
    ..To investigate prostate stem cell antigen (PSCA) and Ki-67 expression in normal-looking epithelium (NEp), atrophy, high-grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma (PCa)...
  60. doi request reprint Secondary neoplasms of the urinary system and male genital organs
    Doriana Morichetti
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    BJU Int 104:770-6. 2009
    ....
  61. ncbi request reprint Apoptotic and proliferation indexes in primary superficial bladder tumors
    Ricardo Gonzalez-Campora
    Department of Pathology, Virgen Macarena University Hospital and University of Seville Medical School, Seville, Spain
    Cancer Lett 242:266-72. 2006
    ..Tumor size, patient's age and tumor's recurrence predicted overall survival. We conclude that conventional clinical parameters and Ki-67 LI define risk groups of bladder tumors, while AI has limited value...
  62. ncbi request reprint Comparison between incidentally and clinically detected prostate cancer: implications for prostate cancer screening programs and focal therapy
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Anal Quant Cytol Histol 32:151-4. 2010
    ....
  63. ncbi request reprint Pathology of renal cell carcinoma: an update
    Antonio Lopez-Beltran
    Anatomical Pathology Unit, Department of Surgery, Faculty of Medicine, University of Cordoba, Cordoba, Spain
    Anal Quant Cytol Histol 35:61-76. 2013
    ....
  64. doi request reprint Lymphocytic vasculitis of the prostate transition zone
    Antonio Lopez-Beltran
    Unit of Anatomic Pathology, Department of Surgery, Faculty of Medicine, Cordoba, Spain
    BJU Int 110:1775-80. 2012
    ..3%) of 15 specimens with prostatic infarction (P < 0.001) with a risk of 124.68 (OR [odds ratio]; 95% CI [confidence interval] 16.07-967.07) as compared with BPH cases not associated with lymphocytic vasculitis...
  65. doi request reprint Diagnosis of isolated high-grade prostatic intra-epithelial neoplasia: proposal of a nomogram for the prediction of cancer detection at saturation re-biopsy
    Marco Roscigno
    Department of Urology and Pathology, Ospedali Riuniti di Bergamo, Bergamo, Italy
    BJU Int 109:1329-34. 2012
    ..Our study developed for the first time a predictive nomogram that could be helpful for patient counselling and to guide the urologist to perform rPBX after an initial diagnosis of isolated HGPIN...
  66. doi request reprint Cystic lesions of the prostate gland: an ultrasound classification with pathological correlation
    Andrea Benedetto Galosi
    Institute of Urology, Section of Pathological Anatomy and Polytechnic University of the Marche Region, School of Medicine, Azienda Ospedaliero Universitaria United Hospitals, Ancona, Italy
    J Urol 181:647-57. 2009
    ..We provide an updated classification of prostate cyst disorders and indicate how these disorders appear on transrectal ultrasound based on our experience and a literature review...
  67. ncbi request reprint Targeted therapies and biological modifiers in urologic tumors: pathobiology and clinical implications
    Antonio Lopez-Beltran
    Unit of Anatomic Pathology, Department of Surgery, Faculty of Medicine, Cordoba, Spain
    Semin Diagn Pathol 25:232-44. 2008
    ..The current status of biological and clinicopathological aspects of targeted therapy in prevalent urologic tumors is reviewed...
  68. doi request reprint Solitary fibrous tumour of the prostate identified on needle biopsy
    Andrea B Galosi
    Urology Institute, Polytechnic University of the Marche Region, Azienda Ospedaliero Universitaria, Ancona, Italy
    Eur Urol 56:564-7. 2009
    ..Owing to their relative rarity and lack of long-term follow-up, the clinical behaviour of prostatic SFTs is difficult to predict. Complete resection of the tumour is currently the single main prognostic factor...
  69. ncbi request reprint Improving inter-observer agreement and certainty level in diagnosing and grading papillary urothelial neoplasms: usefulness of a Bayesian belief network
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, University of Ancona, Umberto 1st Hospital, I 60020 Torrette, Ancona, Italy
    Eur Urol 41:449-57. 2002
    ..The aim of this study was to evaluate the contribution of a BBN in the improvement of inter-observer agreement and certainty level in the diagnosis and grading of papillary urothelial neoplasms...
  70. ncbi request reprint Cell proliferation and apoptosis in prostate needle biopsies with adenocarcinoma Gleason score 6 or 7
    Antonio Lopez-Beltran
    Unit of Anatomic Pathology, Department of Surgery, Faculty of Medicine, Cordoba University Medical School, Cordoba, Spain
    Anal Quant Cytol Histol 34:61-5. 2012
    ..To analyze whether cell proliferation and apoptotic indexes in needle biopsies with prostate cancer Gleason 6 or 7 can identify more objectively Gleason score 6 or 7 in needle biopsy samples...
  71. doi request reprint Handling and reporting of nephrectomy specimens for adult renal tumours: a survey by the European Network of Uropathology
    Ferran Algaba
    Department of Pathology, Fundacion Puigvert University Autonomous, Barcelona, Spain
    J Clin Pathol 65:106-13. 2012
    ..To collect information on current practices of European pathologists for the handling and reporting of nephrectomy specimens with renal tumours...
  72. ncbi request reprint Immunohistochemical evaluation of urokinase plasminogen activator receptor in noninvasive and early invasive urothelial papillary neoplasia
    Caterina Vivani
    Institute of Urology, Laboratory of Cellular and Molecular Biology, Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, Ancona, Via Tronto 10 A, 60020 Ancona, Italy
    Anal Quant Cytol Histol 26:15-21. 2004
    ..To investigate urokinase plasminogen activator receptor (uPAR) expression in urothelial papilloma and in noninvasive and early invasive papillary carcinoma...
  73. pmc Macrocryosectioning and complete sampling of the prostate in a potential multiorgan donor candidate
    Roberta Mazzucchelli
    Unit of Pathological Anatomy, United Hospitals and Polytechnic University of the Marche Region, Ancona, Italy
    J Clin Pathol 60:951-2. 2007
  74. doi request reprint Neuroendocrine tumours of the urinary system and male genital organs: clinical significance
    Roberta Mazzucchelli
    Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    BJU Int 103:1464-70. 2009
    ..Both show the morphology and immunophenotype of NE carcinoma originating in other organs. Although the occurrence is rare, it is highly aggressive...
  75. doi request reprint Invasive micropapillary urothelial carcinoma of the bladder
    Antonio Lopez-Beltran
    Unit of Anatomic Pathology, Department of Surgery, University of Cordoba Faculty of Medicine, E 14004, Cordoba, Spain
    Hum Pathol 41:1159-64. 2010
    ..The morphologic diversity of micropapillary carcinoma may represent a diagnostic pitfall in limited samples, where its distinction from conventional urothelial carcinoma is critical for its clinical management...
  76. ncbi request reprint BCL-2, TP53 and BAX protein expression in superficial urothelial bladder carcinoma
    Ricardo Gonzalez-Campora
    Department of Pathology, Virgen Macarena University Hospital and University of Seville Medical School, Seville, Spain
    Cancer Lett 250:292-9. 2007
    ..023) or TP53+/BAX- (p=0.027) phenotype. BAX and pathologic stage were independent predictors of progression-free and overall survival, respectively. Therefore, BAX expression might be relevant in patient's prognosis...
  77. ncbi request reprint Current practice of Gleason grading of prostate carcinoma
    Antonio Lopez-Beltran
    Department of Pathology, Faculty of Medicine, Reina Sofia University Hospital and Cordoba University Medical School, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Virchows Arch 448:111-8. 2006
    ..This review summarizes the current status of Gleason grading in prostate cancer, incorporating recent proposals for the best contemporary practice of prostate cancer grading...
  78. ncbi request reprint 2004 WHO classification of the renal tumors of the adults
    Antonio Lopez-Beltran
    Department of Pathology, Reina Sofia University Hospital and Cordoba University Medical School, Cordoba, Spain
    Eur Urol 49:798-805. 2006
    ..The recently introduced 2004 World Health Organisation (WHO) classification of the adult renal epithelial neoplasms is meant to replace the previous 1998 WHO classification...
  79. doi request reprint Increased urokinase-type plasminogen activator receptor and epidermal growth factor receptor in serum of patients with prostate cancer
    Giulio Milanese
    Department of Urology, Laboratory of Cellular and Molecular Biology, School of Medicine, Polytechnic University of the Marche Region, Ancona, Italy
    J Urol 181:1393-400. 2009
    ....
  80. ncbi request reprint Evaluation of prognostic factors in radical prostatectomy specimens with cancer
    Roberta Mazzucchelli
    Institute of Pathological Anatomy, University of Ancona School of Medicine, Ancona, Italy
    Urol Int 68:209-15. 2002
    ..The goal is to tailor the therapeutic approach to the clinical, morphological and molecular features of each patient...
  81. ncbi request reprint Pathological variants of invasive bladder cancer according to their suggested clinical significance
    Antonio Lopez-Beltran
    Department of Pathology, Reina Sofia University Hospital and Cordoba University Medical School, Cordoba, Spain
    BJU Int 101:275-81. 2008
    ....
  82. ncbi request reprint Research advances in apoptosis-mediated cancer therapy: a review
    Antonio Lopez-Beltran
    Unit of Anatomic Pathology, Cordoba University Medical School, Reina Sofia University Hospital, Cordoba, Spain
    Anal Quant Cytol Histol 29:71-8. 2007
    ..This review summarizes current observations in the literature related to recent research developments in apoptosis-mediated cancer therapy...
  83. pmc Ki-67 MIB1 labelling index and the prognosis of primary TaT1 urothelial cell carcinoma of the bladder
    A Quintero
    Biomedical Research Unit, Reina Sofia University Hospital and Cordoba University Medical School, 14004 Cordoba, Spain
    J Clin Pathol 59:83-8. 2006
    ..To evaluate whether ki-67 labelling index (LI) has independent prognostic value for survival of patients with bladder urothelial tumours graded according to the 2004 World Health Organisation classification...
  84. ncbi request reprint Karyometric features of low and high grade glial tumors as compared with their MRI appearance
    Marina Scarpelli
    Istituto di Anatomia Patologica, Universita Politecnica delle Marche, Ospedale Nuovo di Torrette, Via Conca, 71, 60020 Torrette, Ancona, Italy
    Anal Quant Cytol Histol 26:87-96. 2004
    ..To compare the results of a magnetic resonance imaging (MRI) grading designed to identify low and high grade gliomas with karyometry used as a tool to grade primary brain tumors...
  85. ncbi request reprint Morphological assessment of radical prostatectomy specimens. A protocol with clinical relevance
    Rodolfo Montironi
    Institute of Pathological Anatomy, University of Ancona School of Medicine, Umberto 1 degrees Hospital, 60020, Torrette, Ancona, Italy
    Virchows Arch 442:211-7. 2003
    ..The pathology report should include relevant clinical information as well as provide prognostically useful information derived from the macroscopic examination and microscopic evaluation of the RP specimen..
  86. pmc Immunohistochemical expression of pi class glutathione S-transferase in the basal cell layer of benign prostate tissue following chronic treatment with finasteride
    R Montironi
    Institute of Pathological Anatomy and Histopathology, School of Medicine, University of Ancona, Ospedale Regionale, Italy
    J Clin Pathol 52:350-4. 1999
    ..Finasteride, a 5-alpha-reductase inhibitor, is used as a chemopreventive agent because it blocks the conversion of testosterone to its byproduct which promotes prostate tumour growth...
  87. ncbi request reprint Activity and expression of nitric oxide synthase in rat bladder after sacral neuromodulation
    D Minardi
    Institute of Urology, Polytechnic University of the Marche Region, Ancona, Italy
    Int J Immunopathol Pharmacol 21:129-35. 2008
    ....
  88. ncbi request reprint Prognostic role of tumor necrosis, microvessel density, vascular endothelial growth factor and hypoxia inducible factor-1alpha in patients with clear cell renal carcinoma after radical nephrectomy in a long term follow-up
    D Minardi
    Institute of Maternal and Children s Sciences Urology, Polytechnic University of the Marche Region, Azienda Ospedaliero Universitaria Ospedali Riuniti, Via Conca 71, Ancona, Italy
    Int J Immunopathol Pharmacol 21:447-55. 2008
    ..The histological and immunohistochemical parameters considered in our study can influence disease recurrence and survival in RCC...
  89. ncbi request reprint Expression of basic fibroblast growth factor, its receptors and syndecans in bladder cancer
    D Marzioni
    Department of Molecular Pathology and Innovative Therapies, Marche Polytechnic University, School of Medicine, Ancona, Italy
    Int J Immunopathol Pharmacol 22:627-38. 2009
    ..In conclusion, our data report that the bFGF, FGFR and syndecan expressions are altered in bladder tumours...
  90. doi request reprint Prognostic role of global DNA-methylation and histone acetylation in pT1a clear cell renal carcinoma in partial nephrectomy specimens
    Daniele Minardi
    Institute of Maternal and Children s Sciences Urology, Polytechnic University of the Marche Region Azienda Ospedaliero Universitaria Ospedali Riuniti, Ancona, Italy
    J Cell Mol Med 13:2115-21. 2009
    ....
  91. ncbi request reprint Immunohistochemical evaluation of global DNA methylation and histone acetylation in papillary urothelial neoplasm of low malignant potential
    F Barbisan
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Int J Immunopathol Pharmacol 21:615-23. 2008
    ..Further studies are needed to elucidate the complex interplay between chromatin structure, its modifications and recurrence of PUNLMP...
  92. ncbi request reprint Prognostic role of Fuhrman grade and vascular endothelial growth factor in pT1a clear cell carcinoma in partial nephrectomy specimens
    D Minardi
    Institute of Urology, Polytechnic University of the Marche Region Medical School, Ancona, Italy
    J Urol 174:1208-12. 2005
    ....
  93. ncbi request reprint Precancerous lesions and conditions of the prostate: from morphological and biological characterization to chemoprevention
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, University of Ancona, Ancona, Italy
    Ann N Y Acad Sci 963:169-84. 2002
    ..Prostatic carcinoma is also likely to arise from precursor lesions other than high-grade PIN such as low-grade PIN, atypical adenomatous hyperplasia, malignancy-associated foci, and atrophy...
  94. ncbi request reprint Handling and pathology reporting of specimens with carcinoma of the urinary bladder, ureter, and renal pelvis
    Antonio Lopez-Beltran
    Department of Pathology, Unit of Anatomic Pathology, Faculty of Medicine, Cordoba University Medical School, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Eur Urol 45:257-66. 2004
    ..Pathologists play a pivotal role in the diagnosis and in the report of the pathological features related to prognosis...
  95. ncbi request reprint The pagetoid variant of bladder urothelial carcinoma in situ A clinicopathological study of 11 cases
    A Lopez-Beltran
    Department of Pathology, Cordoba University Medical School and Reina Sofia University Hospital, Cordoba, Spain
    Virchows Arch 441:148-53. 2002
    ..Our data suggest that a panel of immunostains including CK7+/CK20+/TM+ may assist in differentiating urothelial pagetoid CIS from extramammary Paget disease which is known to be CK7+/CK20-...
  96. ncbi request reprint A practical approach to bladder sampling and diagnostic reporting of pathological findings
    A Lopez-Beltran
    Department of Pathology, Cordoba University Medical School, Cordoba, Spain
    Pathologica 93:688-92. 2001
    ..This protocol is intended to assist pathologists in providing clinically useful information as a result of examination of surgical specimens...
  97. ncbi request reprint Subtle morphological and molecular changes in normal-looking epithelium in prostates with prostatic intraepithelial neoplasia or cancer
    R Montironi
    Institute of Pathological Anatomy and Histopathology, School of Medicine, University of Ancona, Italy
    Eur Urol 35:468-73. 1999
    ..Prostate cancer develops over an extended period of time. Until recently, the events initiating the process and the developments concomitant with the evolution towards invasive disease were largely unknown...
  98. ncbi request reprint Surgical pathology examination of radical prostatectomy specimens. Updated protocol based on the Italian TAP study
    R Mazzucchelli
    Institute of Pathological Anatomy, University of Ancona School of Medicine, Italy
    Anticancer Res 21:3599-607. 2001
    ....
  99. doi request reprint Loss of heterozygosity at 9q32-33 (DBC1 locus) in primary non-invasive papillary urothelial neoplasm of low malignant potential and low-grade urothelial carcinoma of the bladder and their associated normal urothelium
    A Lopez-Beltran
    Department of Pathology, Reina Sofia University Hospital and Cordoba University Medical School, Spain
    J Pathol 215:263-72. 2008
    ....
  100. ncbi request reprint Urothelial papillary lesions. Development of a Bayesian Belief Network for diagnosis and grading
    R Mazzucchelli
    Institute of Pathological Anatomy and Histopathology, University of Ancona, Ancona, Italy
    Anticancer Res 21:1157-62. 2001
    ....
  101. ncbi request reprint Cyclin D3 expression in primary Ta/T1 bladder cancer
    A Lopez-Beltran
    Department of Pathology, Reina Sofia University Hospital and Cordoba University Medical School, Spain
    J Pathol 209:106-13. 2006
    ..4442) and cyclin D1 (p = 0.0065, RR = 3.3023). Cyclin D3 expression had the highest risk ratio. Our results suggest that expression of cyclin D3 is relevant to the progression-free survival of patients with Ta/T1 bladder carcinomas...