Research Topics
Species | Michele Davido MignognaSummaryCountry: Italy Publications
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Publications
Effectiveness of small-volume, intralesional, delayed-release triamcinolone injections in orofacial granulomatosis: a pilot studyM D Mignogna
Department of Odontostomatological and Maxillofacial Sciences, Section of Oral Medicine, University of Naples Federico II, Italy
J Am Acad Dermatol 51:265-8. 2004..Treatment with high-volume triamcinolone injections has been shown to be effective but requires nerve block anesthesia and causes a dramatic temporary increase of lip swelling...- The World Cancer Report and the burden of oral cancerM D Mignogna
Section of Oral Medicine, Department of Odontostomatological and Maxillofacial Sciences, University Federico II of Naples, Italy, Via Pansini 5, 80131 Naples, Italy
Eur J Cancer Prev 13:139-42. 2004.... - Clinical behaviour of malignant transforming oral lichen planusM D Mignogna
Department of Oral Medicine and Pathology, University of Naples Federico II, Faculty of Medicine, School of Dentistry, Naples, Italy
Eur J Surg Oncol 28:838-43. 2002..The aim of this paper is to evaluate clinical long-term behaviour of OLP-related oral squamous cell carcinomas (OSCCs)... - High-dose intravenous 'pulse' methylprednisone in the treatment of severe oropharyngeal pemphigus: a pilot studyMichele Davide Mignogna
Division of Oral Medicine, Department of Odontostomatological and Maxillo Facial Sciences, School of Dentistry, University of Naples, Federico II, Naples, Italy
J Oral Pathol Med 31:339-44. 2002..The aim of the study is to evaluate the capacity of methylprednisolone i.v. 'pulse' therapy to induce remission in the treatment of severe oropharyngeal pemphigus... - Costs and effectiveness in the care of patients with oral and pharyngeal cancer: analysis of a paradoxM D Mignogna
Division of Oral Medicine, Department of Odontostomatological and Maxillo Facial Sciences, University of Naples Federico II, Italy
Eur J Cancer Prev 11:205-8. 2002..These strategies should be directed at prevention and early diagnosis in order to increase patient survival and quality of life and decrease the consumption of health care resources... - Polyglandular autoimmune syndrome type II associated with oral lichen planusMichele Davido Mignogna
Department of Odontostomatological and Maxillofacial Sciences, Division of Oral Medicine, University of Naples Federico II, Via Domenico Fortana 81, Naples, Italy
Int J Dermatol 41:244-6. 2002 - Metastases in small thickness oral squamous-cell carcinoma arising in oral lichen planusM D Mignogna
Department of Odontostomatological and Maxillofacial Sciences, University of Naples Federico II, School of Dentistry, Italy
Med Oncol 18:159-63. 2001.... - Anorexia/bulimia-related sialadenosis of palatal minor salivary glandsM D Mignogna
Section of Oral Medicine, Department of Odontostomatological and Maxillofacial Sciences, University Federico II of Naples, Italy
J Oral Pathol Med 33:441-2. 2004.... - Sjögren's syndrome: the diagnostic potential of early oral manifestations preceding hyposalivation/xerostomiaM D Mignogna
Department of Odontostomatological and Maxillofacial Sciences, Section of Oral Medicine, University of Naples Federico II, Naples, Italy
J Oral Pathol Med 34:1-6. 2005.... - The diagnosis of burning mouth syndrome represents a challenge for cliniciansMichele D Mignogna
Section of Oral Medicine, Department of Odontostomatological and Maxillofacial Sciences University Federico II of Naples, Naples, Italy
J Orofac Pain 19:168-73. 2005..To evaluate the occurrence of professional delay in the diagnosis, referral, and treatment of patients with burning mouth syndrome (BMS)... - Orofacial granulomatosis with gingival onsetM D Mignogna
Researcher, Department of Odontostomatology and Maxillofacial Surgery, Division of Oral Medicine, University of Naples Federico II, School of Dentistry, Naples, Italy
J Clin Periodontol 28:692-6. 2001..Although rarely, a granular enlargements of the gingiva may be the first clinical manifestation of OFG, preceding other local or systemic manifestations... - Immune activation and chronic inflammation as the cause of malignancy in oral lichen planus: is there any evidence ?Michele D Mignogna
Section of Oral Medicine, Department of Odontostomatological and Maxillofacial Sciences, University Federico II, Naples, Italy
Oral Oncol 40:120-30. 2004..With this aim, we critically reviewed and detailed the presence, in OLP subepithelial infiltrate, of inflammatory cells and cytokine networks that might act to promote squamous tumorigenesis... - Clinical features of gingival pemphigus vulgarisM D Mignogna
Department of Odontostomatology and Maxillofacial Surgery, University of Naples Federico II, School of Dentistry, Italy
J Clin Periodontol 28:489-93. 2001..Oral lesions are a hallmark of PV and occur in almost all cases, and represent the preliminary symptom in more than half of the patients. Gingival lesions are very common and, when solitary, often first recognized by periodontist... - Oral cancer screening: 5 minutes to save a lifeMichele D Mignogna
Division of Oral Medicine, Department of Odontostomatological and Maxillofacial Sciences, University of Naples Federico II, 80129, Naples, Italy
Lancet 365:1905-6. 2005 - Gorham's disease of the mandible mimicking periodontal disease on radiographMichele Davide Mignogna
Department of Odontostomatological and Maxillofacial Sciences, Section of Oral Medicine, University Federico II, Naples, Italy
J Clin Periodontol 32:1022-6. 2005.... - Gingival involvement of oral lichen planus in a series of 700 patientsMichele D Mignogna
Department of Odontostomatological and Maxillofacial Sciences, Section of Oral Medicine, University of Naples Federico II, Faculty of Medicine, School of Dentistry, Naples, Italy
J Clin Periodontol 32:1029-33. 2005..This can be potentially harmful since OLP patients require appropriate management in oral and periodontal care, together with an adequate systemic evaluation... - Dysplasia/neoplasia surveillance in oral lichen planus patients: a description of clinical criteria adopted at a single centre and their impact on prognosisMichele D Mignogna
Section of Oral Medicine, Department of Odontostomatological and Maxillofacial Sciences, University Federico II, Via Pansini 5, 80130 Naples, Italy
Oral Oncol 42:819-24. 2006..Nevertheless, a small subgroup of patients has been shown not to benefit from such surveillance and to be characterized by a rapid development of advanced-stage oral carcinomas, with consequent poor prognosis... - The multiform and variable patterns of onset of orofacial granulomatosisMichele D Mignogna
Department of Odontostomatological and Maxillofacial Sciences, Division of Oral Medicine, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy
J Oral Pathol Med 32:200-5. 2003.... - Catenin dislocation in oral pemphigus vulgarisM D Mignogna
Department of Odontostomatology and Maxillofacial Sciences, University of Naples Federico II, Italy
J Oral Pathol Med 30:268-74. 2001..In PV patients, we detected a loss of membrane expression of these molecules with a progressive displacement of the signal toward the cytosol and, for gamma-catenin, nuclear dislocation, particularly in areas with intense acantholysis... - Field cancerization in oral lichen planusM D Mignogna
Section of Oral Medicine, Department of Odontostomatological and Maxillofacial Sciences, University Federico II, Via Pansini 5, 80130, Naples, Italy
Eur J Surg Oncol 33:383-9. 2007..Here we address whether this concept should be extended also to patients affected by oral lichen planus (OLP), an inflammatory disorder associated with an increased risk of cancer development... - Expression of the apoptosis inhibitor survivin in aggressive squamous cell carcinomaL Lo Muzio
Faculty of Medicine, Institute of Dentistry and Maxillo-facial Surgery, Bari, Italy
Exp Mol Pathol 70:249-54. 2001..These data suggest that survivin expression may predictively identify cases of SCC with more aggressive and invasive clinical phenotype, potentially warranting closer follow-up protocols... - Scatter factor receptor (c-Met) as possible prognostic factor in patients with oral squamous cell carcinomaL Lo Muzio
Institute of Dental Sciences, University of Ancona, Ancona, Italy
Anticancer Res 24:1063-9. 2004..The difference between survival rates was statistically significant (p<0.05). These data suggest that c-Met expression may be useful to identify cases of oral squamous cell carcinoma with a more aggressive and invasive phenotype... - P-cadherin expression predicts clinical outcome in oral squamous cell carcinomasL Lo Muzio
Institute of Dental Sciences, University of Ancona, Ancona, Italy
Histol Histopathol 19:1089-99. 2004..05) and poorer survival rates than the group with prevalent membranous expression (P<0.0001). An absent P-cadherin expression could constitute a hallmark of aggressive biological behaviour in oral squamous cell carcinoma... - HSP 27 as possible prognostic factor in patients with oral squamous cell carcinomaL Lo Muzio
Institute of Dental Sciences, University of Ancona, Ancona, Italy
Histol Histopathol 19:119-28. 2004..The aim of this study was to investigate the biological role of HSP27 in oral tumorigenesis... - Immunocytochemical detection of hMSH2 and hMLH1 expression in oral melanomaL Lo Muzio
Department of Oral Medicine and Pathology, University of Naples Federico II, Faculty of Medicine and Surgery, Italy
Anticancer Res 20:741-8. 2000..To date few studies have been performed on hMSH2 and hMLH1 expression and melanoma of the head and neck region. A study of two cases revealed no mutations of the mismatch repair genes hMSH2 and hMLH1... - Primary intraoral leiomyosarcoma of the tongue: an immunohistochemical study and review of the literature- Lo Muzio L
Department of Dentistry and Surgery, University of Bari, Bari, Italy
Oral Oncol 36:519-24. 2000..The patient underwent wide surgical excision of the tumor and is alive and disease-free at a 5-year follow-up. This report emphasizes the difficulties in the differential diagnosis of these uncommon tumors in an intra-oral location... - The human multidrug resistance gene (MDR-1): immunocytochemical detection of its expression in oral SCCL Lo Muzio
Department of Dentistry and Surgery, University of Bari, Italy
Anticancer Res 20:2891-7. 2000.... - Clinical guidelines in early detection of oral squamous cell carcinoma arising in oral lichen planus: a 5-year experienceM D Mignogna
Department of Oral Medicine and Pathology, Faculty of Medicine, School of Dentistry, University of Naples Federico II, Via Domenico Fontana 81 pal 10, 80128, Naples
Oral Oncol 37:262-7. 2001..5% of tumours as in situ OSCC, 38% as microinvasive OSCC, 28.5% as stage I OSCC and 4.7% as stage II OSCC, with a remarkable improvement in prognosis compared to our previous study in which we adopted different criteria... - A possible role of catenin dyslocalization in pemphigus vulgaris pathogenesisL Lo Muzio
Institute of Dental Sciences, University of Ancona, Ancona, Italy
J Cutan Pathol 28:460-9. 2001..The objective of this study was to evaluate the role of beta- and gamma-catenins in the pathogenesis of acantholysis in pemphigus vulgaris... - The treatment of oral aphthous ulceration or erosive lichen planus with topical clobetasol propionate in three preparations: a clinical and pilot study on 54 patientsL Lo Muzio
Institute of Dental Sciences, University of Ancona, Italy
J Oral Pathol Med 30:611-7. 2001..This study evaluated the clinical use of a corticosteroid in three preparations (topical clobetasol propionate ointment, clobetasol propionate in an oral analgesic base, and clobetasol propionate in an adhesive denture paste)... - p120(cat) Delocalization in cell lines of oral cancerL Lo Muzio
Institute of Dental Sciences, University of Ancona, Ancona, Italy
Oral Oncol 38:64-72. 2002..In conclusions, this nuclear delocalization for p120 could suppose its potential involvement in signalling and cancer transformation... - Expression of bcl-2 in oral squamous cell carcinoma: an immunohistochemical study of 90 cases with clinico-pathological correlationsL Lo Muzio
Institute of Dental Sciences, Faculty of Medicine, University of Ancona, Italy
Oncol Rep 10:285-91. 2003..The study of bcl-2 immunoreactivity possibly may be useful for better characterising and predicting the prognosis of oral SCC but cooperative studies are needed to assess its applications in the clinical practice... - Survivin expression in oral squamous cell carcinomaL Lo Muzio
Institute of Dental Sciences, Faculty of Medicine, University of Ancona, Ancona, Italy
Br J Cancer 89:2244-8. 2003..05). These data suggest that survivin expression may identify cases of oral SCC with more aggressive and invasive phenotype... - Survivin, a potential early predictor of tumor progression in the oral mucosaL Lo Muzio
Institute of Dental Sciences, Faculty of Medicine, University of Ancona, Ancona, Italy
J Dent Res 82:923-8. 2003..High expression of cytoplasmic/nuclear survivin is an early event during oral carcinogenesis and may provide a useful tool for the identification of precancerous lesions at higher risk of progression into invasive carcinoma... - Macroscopic classification of superficial neoplastic lesions of the oral mucosa: a preliminary studyS Fedele
Section of Oral Medicine, Department of Odontostomatological and Maxillofacial Sciences, University Federico II, Via Pansini 5, 80130, Naples, Italy
Eur J Surg Oncol 34:100-6. 2008..Failure in diagnosing oral malignancy at an early stage is a major culprit, and the lack of a worldwide adopted classification of its macroscopic appearance, similar to that of gastrointestinal neoplasias, may have contributed to it... - Oral pemphigus: clinical significance of esophageal involvement: report of eight casesM D Mignogna
Department of Oral Medicine, University of Naples Federico II, School of Dentistry, Italy
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 84:179-84. 1997..Direct immunofluorescence was positive in all eight patients. It is suggested that endoscopic examination of esophageal mucosa is an objective criterion by which to judge the success of therapy of pemphigus vulgaris... - Analysis of thromboembolic risk related to high-dose intravenous immunoglobulin treatment: a preliminary clinical study of 10 patients with autoimmune mucocutaneous blistering diseasesM D Mignogna
Section of Oral Medicine, Department of Odontostomatological and Maxillo facial Science of the School of Medicine and Surgery, University of Naples Federico II, Naples, Italy
Clin Exp Dermatol 34:145-50. 2009..Currently no data are available in the literature about the role of IVIg in the pathogenesis of thromboembolic events in patients with autoimmune blistering diseases refractory to conventional immunosuppressive treatment... - Oral pemphigusM D Mignogna
Oral Medicine Unit, Department of Odontostomatologica and Maxillo facial Science, School of Medicine and Surgery, Federico II University, Naples, Italy
Minerva Stomatol 58:501-18. 2009..Nonetheless, newer therapies, such as intravenous immunoglobulins (IVIg) or anti-CD20 monoclonal antibodies (Rituximab), with potentially fewer adverse effects also appear promising...