Sebastiano Mercadante

Summary

Country: Italy

Publications

  1. ncbi Pain mechanisms involved and outcome in advanced cancer patients with possible indications for celiac plexus block and superior hypogastric plexus block
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Home Palliative Care Program, SAMOT Società per l Assistenza al Malato Oncologico Terminale, Palermo, Italy
    Tumori 88:243-5. 2002
  2. ncbi Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: a prospective study
    S Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Clin Oncol 19:2898-904. 2001
  3. ncbi Gabapentin for opiod-related myoclonus in cancer patients
    S Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Centre, Palermo, Italy
    Support Care Cancer 9:205-6. 2001
  4. ncbi The use of corticosteroids in home palliative care
    S Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Clinic for Cancer, Palermo, Italy
    Support Care Cancer 9:386-9. 2001
  5. ncbi Pharmacotherapy of anaemia in cancer patients
    S Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Clinic for Cancer, Palermo, Italy
    Expert Opin Pharmacother 2:1949-61. 2001
  6. ncbi Episodic (breakthrough) pain: consensus conference of an expert working group of the European Association for Palliative Care
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Cancer 94:832-9. 2002
  7. ncbi The use of bisphosphonates in the management of bone metastatic prostate cancer
    Sebastiano Mercadante
    Anestesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via S Lorenzo 312, Palermo, 90146, Italy
    Curr Urol Rep 3:244-9. 2002
  8. ncbi A randomised controlled study on the use of anti-inflammatory drugs in patients with cancer pain on morphine therapy: effects on dose-escalation and a pharmacoeconomic analysis
    S Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, via San Lorenzo Colli no 312, 90146, Palermo, Italy
    Eur J Cancer 38:1358-63. 2002
  9. ncbi Rapid titration with intravenous morphine for severe cancer pain and immediate oral conversion
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Cancer 95:203-8. 2002
  10. ncbi Amitriptyline in neuropathic cancer pain in patients on morphine therapy: a randomized placebo-controlled, double-blind crossover study
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Home Palliative Care Program, Società Assistenza Malato Oncologico Terminale, Palermo, Italy
    Tumori 88:239-42. 2002

Detail Information

Publications132 found, 100 shown here

  1. ncbi Pain mechanisms involved and outcome in advanced cancer patients with possible indications for celiac plexus block and superior hypogastric plexus block
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Home Palliative Care Program, SAMOT Società per l Assistenza al Malato Oncologico Terminale, Palermo, Italy
    Tumori 88:243-5. 2002
    ....
  2. ncbi Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: a prospective study
    S Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Clin Oncol 19:2898-904. 2001
    ..To evaluate the clinical benefits of switching from morphine to oral methadone in patients who experience poor analgesia or adverse effects from morphine...
  3. ncbi Gabapentin for opiod-related myoclonus in cancer patients
    S Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Centre, Palermo, Italy
    Support Care Cancer 9:205-6. 2001
    ..Gabapentin seemed a likely candidate for the treatment of this myoclonus and has indeed proved useful, as illustrated in this paper by two case histories...
  4. ncbi The use of corticosteroids in home palliative care
    S Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Clinic for Cancer, Palermo, Italy
    Support Care Cancer 9:386-9. 2001
    ..These findings will be very useful in the planning of future controlled studies designed to yield evidence-based data on the role of corticosteroids in the relief of specific symptoms...
  5. ncbi Pharmacotherapy of anaemia in cancer patients
    S Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Clinic for Cancer, Palermo, Italy
    Expert Opin Pharmacother 2:1949-61. 2001
    ..EPO treatment has been found to be effective in preventing anaemia and reducing the need for blood transfusions, although it would be useful to identify high-risk patient subgroups who would benefit most from this expensive treatment...
  6. ncbi Episodic (breakthrough) pain: consensus conference of an expert working group of the European Association for Palliative Care
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Cancer 94:832-9. 2002
    ..The wide differences in estimation of incidence reported in literature are probably because of different settings and meanings attributed to the definition of breakthrough pain...
  7. ncbi The use of bisphosphonates in the management of bone metastatic prostate cancer
    Sebastiano Mercadante
    Anestesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via S Lorenzo 312, Palermo, 90146, Italy
    Curr Urol Rep 3:244-9. 2002
    ..Studies of the efficacy of lower doses to prevent skeletal morbidity in patients without metastases or with asymptomatic bone lesions are warranted...
  8. ncbi A randomised controlled study on the use of anti-inflammatory drugs in patients with cancer pain on morphine therapy: effects on dose-escalation and a pharmacoeconomic analysis
    S Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, via San Lorenzo Colli no 312, 90146, Palermo, Italy
    Eur J Cancer 38:1358-63. 2002
    ..Their use is associated with a more intense gastric discomfort, but results in less opioid-related constipation. The eventual additive cost for NSAIDs therapy is negligible, especially in patients taking high doses of morphine...
  9. ncbi Rapid titration with intravenous morphine for severe cancer pain and immediate oral conversion
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Cancer 95:203-8. 2002
    ..The aim of the current study was to evaluate a method of rapid titration with intravenous morphine to achieve relief of cancer pain of severe intensity...
  10. ncbi Amitriptyline in neuropathic cancer pain in patients on morphine therapy: a randomized placebo-controlled, double-blind crossover study
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Home Palliative Care Program, Società Assistenza Malato Oncologico Terminale, Palermo, Italy
    Tumori 88:239-42. 2002
    ..A randomized placebo-controlled, double-blind crossover study was designed to evidence the effects of amitriptyline in patients with neuropathic cancer pain...
  11. ncbi The use of anti-inflammatory drugs in cancer pain
    S Mercadante
    Pain Relief and Palliative Care, SAMOT, Palermo, Italy
    Cancer Treat Rev 27:51-61. 2001
    ..Those NSAIDs that are weak COX-1 inhibitors may be preferred. In addition, concomitant administration of misoprostol is recommended in patients at increased risk for upper gastrointestinal complications...
  12. ncbi Controversies over spinal treatment in advanced cancer patients
    S Mercadante
    SAMOT, Palermo, Italy
    Support Care Cancer 6:495-502. 1998
    ..The main problems involved are dealt with an attempt to find how to use the drugs and techniques involved to the best possible advantage...
  13. ncbi When all else fails: stepwise multiple solutions for a complex cancer pain syndrome
    S Mercadante
    Pain Relief and Palliative Care, SAMOT, Palermo, Italy
    Support Care Cancer 7:47-50. 1999
    ..A stepwise and a meaningful approach to clinical problems with use of advanced techniques and alternative drugs in the patient's home may be helpful in the treatment of conditions otherwise considered intractable...
  14. ncbi The role of morphine glucuronides in cancer pain
    S Mercadante
    Palliat Med 13:95-104. 1999
    ....
  15. ncbi Opioid responsiveness in patients with advanced head and neck cancer
    S Mercadante
    Pain Relief and Palliative Care, SAMOT, Palermo, Italy
    Support Care Cancer 6:482-5. 1998
    ....
  16. ncbi Rapid switching from morphine to methadone in cancer patients with poor response to morphine
    S Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Clinic for Cancer, Palermo, Italy
    J Clin Oncol 17:3307-12. 1999
    ....
  17. ncbi Factors influencing the opioid response in advanced cancer patients with pain followed at home: the effects of age and gender
    S Mercadante
    Home Care Program, SAMOT, Società per l Assistenza al Malato Oncologico Terminale, Palermo, Italy
    Support Care Cancer 8:123-30. 2000
    ..Age and gender analysis should be included in all cancer pain and symptom control studies, as they may have an influence on cancer pain prognosis...
  18. ncbi Comparison of octreotide and hyoscine butylbromide in controlling gastrointestinal symptoms due to malignant inoperable bowel obstruction
    S Mercadante
    Pain Relief and Palliative Care, SAMOT, Palermo, Italy
    Support Care Cancer 8:188-91. 2000
    ..Further studies are necessary to understand the role of hydration more clearly in such a clinical situation...
  19. ncbi Pathophysiology and treatment of opioid-related myoclonus in cancer patients
    S Mercadante
    Pain Relief and Palliative Care, SAMOT, Palermo, Italy
    Pain 74:5-9. 1998
    ..A change in the type of opioid may be useful in patients who develop severe central adverse effects, even if these patients appear to have normal renal function or hydration status...
  20. ncbi Anaemia in cancer: pathophysiology and treatment
    S Mercadante
    La Maddalena Clinic for Cancer, Palermo, Italy
    Cancer Treat Rev 26:303-11. 2000
    ..These measures are unlikely to have an effect in irreversible and progressive bleeding states...
  21. ncbi Morphine versus methadone in the pain treatment of advanced-cancer patients followed up at home
    S Mercadante
    Pain Relief and Palliative Care, Societá a Maluto Oncologico Terminale, University of Palermo, Italy
    J Clin Oncol 16:3656-61. 1998
    ..The aim of this study was to evaluate the analgesic and adverse effects and the doses of methadone in comparison to morphine...
  22. doi Sustained-release oral morphine versus transdermal fentanyl and oral methadone in cancer pain management
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    Eur J Pain 12:1040-6. 2008
    ....
  23. doi Palliative sedation in advanced cancer patients followed at home: a retrospective analysis
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 43:1126-30. 2012
    ..Data regarding palliative sedation at home in dying patients are lacking...
  24. ncbi Switching from transdermal drugs: an observational "N of 1" study of fentanyl and buprenorphine
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 34:532-8. 2007
    ..Further studies should be performed to gather data about the use of TTS BU with other opioids, at different doses, and in different clinical conditions...
  25. doi Opioid switching in patients with advanced cancer followed at home. A retrospective analysis
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 45:298-304. 2013
    ..Opioid switching has been found to improve opioid responsiveness in different conditions. However, data on opioid switching performed at home are almost nonexistent, despite the fact that most patients are followed at home...
  26. ncbi Intrathecal treatment in cancer patients unresponsive to multiple trials of systemic opioids
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Clin J Pain 23:793-8. 2007
    ....
  27. ncbi Safety and effectiveness of intravenous morphine for episodic breakthrough pain in patients receiving transdermal buprenorphine
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 32:175-9. 2006
    ..The occurrence of adverse effects for each episode treated was not frequent and intensity was not relevant. IV-MO was effective and safe in most cancer patients receiving TTS-BUP who experienced pain exacerbation...
  28. doi Opioid switching from and to tapentadol extended release in cancer patients: conversion ratio with other opioids
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Curr Med Res Opin 29:661-6. 2013
    ..The aim of this exploratory study was to assess the conversion ratios between tapentadol and other opioids in patients requiring an opioid switching...
  29. doi Prognostic factors of survival in patients with advanced cancer admitted to home care
    Sebastiano Mercadante
    Pain Relief and Supportive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 45:56-62. 2013
    ..Data regarding prognostication of life expectancy in patients with advanced cancer are of paramount importance to patients, families, and clinicians. However, data regarding patients followed at home are lacking...
  30. ncbi Randomized double-blind, double-dummy crossover clinical trial of oral tramadol versus rectal tramadol administration in opioid-naive cancer patients with pain
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, 90146 Palermo, Italy
    Support Care Cancer 13:702-7. 2005
    ..0002) and patients (P=0.002). Rectal administration of tramadol appears a reliable, noninvasive alternative method of pain control for patients no longer responsive to non-opioid analgesics, unable to take oral tramadol...
  31. ncbi Addition of a second opioid may improve opioid response in cancer pain: preliminary data
    Sebastiano Mercadante
    La Maddalena Cancer Center, Palliative Medicine Chair of Anesthesia, Intensive Care and Emergency, Palermo, Italy
    Support Care Cancer 12:762-6. 2004
    ..It allowed for a regaining of analgesia, regardless of the opioid combination used. These preliminary observations should be confirmed in further studies...
  32. doi The use of opioids for breakthrough pain in acute palliative care unit by using doses proportional to opioid basal regimen
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Clin J Pain 26:306-9. 2010
    ..To determine the efficacy and safety of different opioids used in doses proportional to the basal opioid regimen for the management of breakthrough pain (BP)...
  33. doi Does pain intensity predict a poor opioid response in cancer patients?
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Italy
    Eur J Cancer 47:713-7. 2011
    ..The aim of this study was to test the hypothesis that initial pain intensity is not a predictive factor of poor opioid response in advanced cancer patients, as suggested by a recent work...
  34. doi Cancer pain management in an oncological ward in a comprehensive cancer center with an established palliative care unit
    Sebastiano Mercadante
    Anesthesia and Intensive Care and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, and Palliative Medicine, University of Palermo, Via S Lorenzo 312, 90145, Palermo, Italy
    Support Care Cancer 21:3287-92. 2013
    ..This survey was performed to draw information on pain prevalence, intensity, and management from a sample of patients who were admitted to an oncologic center where a palliative care unit (PCU) has been established for 13 years...
  35. doi The effects of low doses of pregabalin on morphine analgesia in advanced cancer patients
    Sebastiano Mercadante
    La Maddalena Cancer Center, Pain Relief and Palliative Care Unit, University of Palermo, Italy
    Clin J Pain 29:15-9. 2013
    ..The aim of this study was to evaluate the opioid response in patients receiving morphine and pregabalin, independently from the presumed pain mechanisms, in comparison with patients receiving morphine treatment only...
  36. doi How do cancer patients receiving palliative care at home die? A descriptive study
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 42:702-9. 2011
    ..Data regarding the circumstances of the process of death of terminally ill patients followed at home are lacking...
  37. doi Frequency, indications, outcomes, and predictive factors of opioid switching in an acute palliative care unit
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, University of Palermo, Palermo, Italy
    J Pain Symptom Manage 37:632-41. 2009
    ..The presence of both poor pain relief and adverse effects is a negative factor for switching prognosis, whereas renal failure is not...
  38. doi When the progression of disease lowers opioid requirement in cancer patients
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, Palermo, Italy
    Clin J Pain 26:56-7. 2010
    ..To describe 2 cases in which an abrupt progression of disease compromising pain pathways and inducing some relief of existing pain or limiting drug delivery to central nervous system...
  39. doi Tools for identifying cancer pain of predominantly neuropathic origin and opioid responsiveness in cancer patients
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain 10:594-600. 2009
    ..05), and patients with "definite NP" required more intensive treatment. Patients requiring more aggressive treatment showed significantly higher values of Opioid Escalation Index (OEI)mg...
  40. ncbi Opioid plasma concentrations during a switch from transdermal fentanyl to methadone
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Palliat Med 10:338-44. 2007
    ....
  41. ncbi Breakthrough pain in advanced cancer patients followed at home: a longitudinal study
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 38:554-60. 2009
    ..This helps explain the different incidences reported in previous studies performed in different settings and conditions...
  42. doi Tapentadol in cancer pain management: a prospective open-label study
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, 90146 Palermo, Italy
    Curr Med Res Opin 28:1775-9. 2012
    ..The aim of this prospective, open-label study was to evaluate the efficacy and tolerability of tapentadol (TP) in the management of cancer pain...
  43. doi Controlled sedation for refractory symptoms in dying patients
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 37:771-9. 2009
    ..This study also points to the importance of palliative care and the experience of professionals skilled in both symptom control and end-of-life care...
  44. doi Emergencies in patients with advanced cancer followed at home
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 44:295-300. 2012
    ..Caregivers may call medical services for an emergency, which can result in patients being admitted to the hospital. No data exist on emergencies in patients followed by a home care team...
  45. doi Intravenous morphine for breakthrough (episodic-) pain in an acute palliative care unit: a confirmatory study
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, University of Palermo, Palermo, Italy
    J Pain Symptom Manage 35:307-13. 2008
    ..The role of nurses is of paramount importance in monitoring and collecting data and gathering information for audit purposes on the unit...
  46. doi Breakthrough pain in oncology: a longitudinal study
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 40:183-90. 2010
    ..These studies have used cross-sectional designs, and the relationship of BP with analgesic treatment has not been evaluated...
  47. ncbi Morphine versus oxycodone in pancreatic cancer pain: a randomized controlled study
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    Clin J Pain 26:794-7. 2010
    ..It was hypothesized that OX could have some advantages over MO in terms of efficacy and dose escalation in pancreatic cancer pain...
  48. ncbi Safety and effectiveness of intravenous morphine for episodic (breakthrough) pain using a fixed ratio with the oral daily morphine dose
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 27:352-9. 2004
    ..v.-M at a dose equivalent to 20% of the basal oral dosage is safe and effective in the majority of patients experiencing pain exacerbation. This treatment is inexpensive and can be used at little risk to patients...
  49. ncbi The use of fentanyl buccal tablets for breakthrough pain by using doses proportional to opioid basal regimen in a home care setting
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via S Lorenzo 312, 90145, Palermo, Italy
    Support Care Cancer 21:2335-9. 2013
    ..This study suggests that FBT given in doses proportional to the basal opioid regimen for the management of BTcP is very effective and safe in clinical practice in the home care setting...
  50. ncbi The poor use of methadone in Italian hospices
    Sebastiano Mercadante
    Anesthesia and Intensive Care and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center and University of Palermo, Via S Lorenzo 312, 90145, Palermo, Italy
    Support Care Cancer 21:2225-8. 2013
    ..The aim of this survey was to investigate the frequency of the use of methadone in Italian hospices and how it is used...
  51. doi Relationship between background cancer pain, breakthrough pain, and analgesic treatment: a preliminary study for a better interpretation of epidemiological and clinical studies
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Curr Med Res Opin 29:667-71. 2013
    ..The different operational definitions of breakthrough cancer pain (BTcP) has generated unclear epidemiological data...
  52. doi Switching from oxycodone to methadone in advanced cancer patients
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146, Palermo, Italy
    Support Care Cancer 20:191-4. 2012
    ..The aim of this study was to prospectively evaluate the outcomes and the conversion ratio of switching from oxycodone to methadone in advanced cancer patients admitted to an acute palliative care unit...
  53. doi Equipotent doses to switch from high doses of opioids to transdermal buprenorphine
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center and University of Palermo, Via San Lorenzo 312, 90146 Palermo, Italy
    Support Care Cancer 17:715-8. 2009
    ....
  54. ncbi Hyperalgesia and opioid switching
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Department of Palliative Medicine, University of Palermo, Palermo, Italy
    Am J Hosp Palliat Care 22:291-4. 2005
    ....
  55. ncbi Alternative treatments of breakthrough pain in patients receiving spinal analgesics for cancer pain
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 30:485-91. 2005
    ..These intensive treatments should be reserved for a very selected population and initiated in an appropriate setting with frequent monitoring facilities and skilled nursing...
  56. ncbi Low morphine doses in opioid-naive cancer patients with pain
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Clinic for Cancer, and Department of Anesthesiology and Intensive Care, University of Palermo, Palermo, Italy
    J Pain Symptom Manage 31:242-7. 2006
    ....
  57. ncbi Is there a ceiling effect of transdermal buprenorphine? Preliminary data in cancer patients
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90145, Palermo, Italy
    Support Care Cancer 15:441-4. 2007
    ....
  58. doi Low doses of transdermal fentanyl in opioid-naive patients with cancer pain
    Sebastiano Mercadante
    Anaesthesia and Intensive Care Unit, and Pain Relief and Palliative Care Unit, La Maddalena Cancer Centre, Palermo, Italy
    Curr Med Res Opin 26:2765-8. 2010
    ..The aim of this study was to evaluate the effect and tolerability of low doses of transdermal (TD) fentanyl patches in opioid-naive patients with cancer pain...
  59. doi The use of high doses of oxycodone in an acute palliative care unit
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Am J Hosp Palliat Care 28:242-4. 2011
    ..This study demonstrated that CRO administered in larger doses was safe and effective, showing versatility and flexibility similar to morphine...
  60. doi The use of fentanyl buccal tablets as breakthrough medication in patients receiving chronic methadone therapy: an open label preliminary study
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Support Care Cancer 19:435-8. 2011
    ..Whether methadone produces tolerance to other opioids, other opioids should be less effective when administered as a BTcP medication...
  61. ncbi Rapid switching between transdermal fentanyl and methadone in cancer patients
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    J Clin Oncol 23:5229-34. 2005
    ..The aim of this study was to examine the clinical effects of switching from transdermal (TTS) fentanyl to methadone, or vice versa, in patients with a poor response to the previous opioid...
  62. ncbi Dialogues on complex analgesic strategies for difficult pain syndromes
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via S Lorenzo 312, 90146 Palermo, Italy
    Support Care Cancer 12:599-603. 2004
    ..Three case reports illustrate how complex could be the analgesic approach using multiple analgesic regimens and different routes of administration to effectively manage complex pain syndromes commonly defined as unresponsive...
  63. doi Palliative sedation in patients with advanced cancer followed at home: a systematic review
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 41:754-60. 2011
    ..Palliative sedation (PS) is considered to be an effective treatment modality for these refractory symptoms when aggressive efforts fail to provide relief...
  64. doi Dosing fentanyl buccal tablet for breakthrough cancer pain: dose titration versus proportional doses
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Curr Med Res Opin 28:963-8. 2012
    ....
  65. ncbi Factors involved in gastrointestinal bleeding in advanced cancer patients followed at home
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via S Lorenzo 312, 90145, Palermo, Italy
    Support Care Cancer 12:95-8. 2004
    ..However, no clear relationship between age, gender, and the use of offender drugs with gastrointestinal bleeding was found. Liver involvement was frequently associated with the risk of developing gastrointestinal bleeding...
  66. doi Opioid switching and burst ketamine to improve the opioid response in patients with movement-related pain due to bone metastases
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo Colli 312, 90146 Palermo, Italy
    Clin J Pain 25:648-9. 2009
    ..To improve opioid repsonse in patients with movement-related pain by using opioid switching adding a burst of ketamine...
  67. doi The use of opioids in the last week of life in an acute palliative care unit
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Am J Hosp Palliat Care 27:514-7. 2010
    ..Doses increases prevalently observed in sedated patients were performed before starting sedation with the purpose to treat concomitant distressing symptoms, such as dyspnoea...
  68. ncbi Aggressive pharmacological treatment for reversing malignant bowel obstruction
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 28:412-6. 2004
    ..It suggests that the most important mechanism in these circumstances is functional and can be reversible, if an aggressive treatment is initiated early before fecal impaction and edema render bowel obstruction irreversible...
  69. ncbi Cancer pain management in children
    Sebastiano Mercadante
    La Maddalena Cancer Center, Palermo, Italy
    Palliat Med 18:654-62. 2004
    ....
  70. doi Sexuality in patients with advanced cancer: a prospective study in a population admitted to an acute pain relief and palliative care unit
    Valentina Vitrano
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Am J Hosp Palliat Care 28:198-202. 2011
    ....
  71. ncbi Celiac plexus block for pancreatic cancer pain: factors influencing pain, symptoms and quality of life
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 26:1140-7. 2003
    ..Outcomes are strongly based on individual variation...
  72. ncbi Treatment strategies for cancer patients with breakthrough pain
    Alessandra Casuccio
    University of Palermo, Department of Clinical Neuroscience, Palermo, Italy
    Expert Opin Pharmacother 10:947-53. 2009
    ..It is normally severe in intensity, has a rapid onset, has a variable duration (on average 30 min) and is considered a negative prognostic factor...
  73. ncbi Optimization of opioid therapy for preventing incident pain associated with bone metastases
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 28:505-10. 2004
    ..This approach is based on experimental bone models showing a hypersensitivity to some innocuous stimuli, such as movement, requiring pre-emptive higher doses of basal opioid medication to reduce the increased pain input...
  74. doi Prevalence and treatment of cancer pain in Italian oncological wards centres: a cross-sectional survey
    Sebastiano Mercadante
    La Maddalena Cancer Center, Palermo, Italy
    Support Care Cancer 16:1203-11. 2008
    ....
  75. doi Intravenous morphine for management of cancer pain
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Cancer Center and Palliative Medicine, Department of Anesthesia and Intensive Care, University of Palermo, Palermo, Italy
    Lancet Oncol 11:484-9. 2010
    ..I.v. morphine is advantageous in specific clinical situations and should be part of armamentarium of all physicians treating pain in patients with cancer...
  76. ncbi A randomized-controlled study of intrathecal versus epidural thoracic analgesia in patients undergoing abdominal cancer surgery
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    J Clin Monit Comput 22:293-8. 2008
    ....
  77. ncbi Opioid plasma concentration during switching from morphine to methadone: preliminary data
    S Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via S Lorenzo 312, 90146 Palermo, Italy
    Support Care Cancer 11:326-31. 2003
    ..Opioid plasma changes substantially overlap the clinical changes observed in these patients, in terms of benefit between analgesia and adverse effects...
  78. ncbi Clinical and financial analysis of an acute palliative care unit in an oncological department
    S Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Palliat Med 22:760-7. 2008
    ..Our findings also suggest both a cost and quality incentive for oncological departments to develop APC...
  79. pmc Transmucosal fentanyl vs intravenous morphine in doses proportional to basal opioid regimen for episodic-breakthrough pain
    S Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Br J Cancer 96:1828-33. 2007
    ..Future comparative studies with appropriate design should compare titration methods and proportional methods of OTFC dosing...
  80. ncbi World Health Organization guidelines for cancer pain: a reappraisal
    S Mercadante
    Anesthesia and Intensive Care Unit, La Maddalena Clinic for Cancer, Palermo, Italy
    Ann Oncol 16:iv132-135. 2005
  81. ncbi Problems of long-term spinal opioid treatment in advanced cancer patients
    S Mercadante
    Pain Relief and Palliative Care, SAMOT, Palermo, Italy
    Pain 79:1-13. 1999
    ..Areas for additional research include the use of spinal adjuvants, the ideal spinal morphine-bupivacaine ratio. methods to improve spinal opioid responsiveness and long-term catheter management with appropriate home care programs...
  82. ncbi Effects of caffeine as an adjuvant to morphine in advanced cancer patients. A randomized, double-blind, placebo-controlled, crossover study
    S Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Clinic for Cancer, Palermo, Italy
    J Pain Symptom Manage 21:369-72. 2001
    ..Further studies are necessary to evaluate whether higher doses of caffeine may be more effective and to establish the role of tolerance to caffeine in this group of patients...
  83. ncbi Local anesthetic switching for intrathecal tachyphylaxis in cancer patients with pain
    S Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Anesth Analg 97:187-9, table of contents. 2003
    ..Switching from bupivacaine to lidocaine may improve intrathecal morphine analgesia in advanced cancer patients, possibly because of different spinal mechanisms limiting the hyperalgesic processes...
  84. ncbi Scoring the effect of radiotherapy for painful bone metastases
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Via San Lorenzo, Palermo, Italy
    Support Care Cancer 14:967-9. 2006
    ..An integration of competences in monitoring the pain response and modifying the opioid treatment according to changes of the clinical condition is mandatory...
  85. ncbi Opioid switching: a systematic and critical review
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90146 Palermo, Italy
    Cancer Treat Rev 32:304-15. 2006
    ..The process of reaching an optimal dose should be highly individualized, particularly when patients are switched from high doses of opioids, given the wide conversion ratios reported in literature...
  86. ncbi Pharmacological management of cancer pain in the elderly
    Sebastiano Mercadante
    Anesthesia and Intensive Care Pain Unit, La Maddalena Cancer Center, and Palliative Medicine, University of Palermo, Palermo, Italy
    Drugs Aging 24:761-76. 2007
    ..Older patients with cancer should be continuously assessed for cancer pain, both before and after analgesic treatment...
  87. ncbi Why are our patients still suffering pain?
    Sebastiano Mercadante
    La Maddalena Cancer Center, Via San Lorenzo 312, 90145 Palermo, Italy
    Nat Clin Pract Oncol 4:138-9. 2007
  88. ncbi Methadone in treatment of tenesmus not responding to morphine escalation
    S Mercadante
    SAMOT, via Libertà 191, 90145 Palermo, Italy
    Support Care Cancer 9:129-30. 2001
    ..Methadone has been reported to improve pain relief in patients with morphine resistance, and it is lipophilic and exerts a lesser activity on opioid receptors in the gastrointestinal tract...
  89. ncbi A comparison of intranasal fentanyl spray with oral transmucosal fentanyl citrate for the treatment of breakthrough cancer pain: an open-label, randomised, crossover trial
    S Mercadante
    Dipartimento Oncologico, Casa di Cura ad alta specialità Pain relief and Palliative Care Unit, La Maddalena, Via S Lorenzo Colli 312, Palermo, Italy
    Curr Med Res Opin 25:2805-15. 2009
    ..The efficacy of intranasal fentanyl spray (INFS) was compared with that of oral transmucosal fentanyl citrate (OTFC) for the relief of cancer-related breakthrough pain (BTP) in an open-label, crossover trial...
  90. ncbi Opioid titration in cancer pain: a critical review
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Eur J Pain 11:823-30. 2007
    ..This review assesses the principal titration methods and outcomes regarding the different opioid drugs and their modalities of administration, in different clinical contexts...
  91. ncbi Opioid escalation in patients with cancer pain: the effect of age
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Clinic for Cancer, Palermo, Italy
    J Pain Symptom Manage 32:413-9. 2006
    ..However, the group of patients over 75 was relatively small and data should be interpreted with caution. Careful titration based on the individual response seems appropriate irrespective of age...
  92. ncbi Hyperalgesia: an emerging iatrogenic syndrome
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 26:769-75. 2003
    ..Alternative procedures should be taken into consideration to break this cycle, should it occur. More data are needed to detect this condition, as currently no diagnostic information on specific markers, clinical or biochemical, exists...
  93. ncbi Management of painful bone metastases
    Sebastiano Mercadante
    Anesthesia and Intensive Care Unit La Maddalena Cancer Center, University of Palermo, Palermo, Italy
    Curr Opin Oncol 19:308-14. 2007
    ..This review examines recent data on the pathophysiology and mechanisms of bone pain; it highlights the use of multiple and interdisciplinary treatments rather than sole use of traditional analgesics...
  94. ncbi Recent progress in the pharmacotherapy of cancer pain
    S Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    Expert Rev Anticancer Ther 1:487-94. 2001
    ..Recent studies have demonstrated the value of these alternative approaches. However, most of them require definite confirmation in specific well-designed studies...
  95. ncbi Rifampicin in opioid-induced itching
    S Mercadante
    Anaesthesia and Intensive Care Unit, La Maddalena Clinic for Cancer, Palermo, Italy
    Support Care Cancer 9:467-8. 2001
    ..v. route was successful, and after opioid switching it was no longer necessary to maintain rifampicin in the therapeutic regimen. Controlled clinical trials are warranted to confirm this preliminary observation...
  96. ncbi Opioid poorly-responsive cancer pain. Part 3. Clinical strategies to improve opioid responsiveness
    S Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 21:338-54. 2001
    ..Other approaches, including opioid trials, neural blockade when necessary, and psychological interventions, also may be useful...
  97. ncbi Opioid poorly-responsive cancer pain. Part 2: basic mechanisms that could shift dose response for analgesia
    S Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 21:255-64. 2001
    ..Research findings can be valuable in formulating new strategies in clinical practice. This review evaluated experimental observations in terms of the events that occur in cancer patients receiving opioid therapy for pain...
  98. ncbi Opioid poorly-responsive cancer pain. Part 1: clinical considerations
    S Mercadante
    Anesthesia and Intensive Care Unit and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy
    J Pain Symptom Manage 21:144-50. 2001
    ..These factors influence the delicate balance between pain relief and opioid toxicity that must be achieved in cancer patients with pain...
  99. ncbi Pattern of drug use by advanced cancer patients followed at home
    S Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Clinic for Cancer, Pain Relief and Palliative Care, Palermo, Italy
    J Palliat Care 17:37-40. 2001
    ..Pharmacological usage should be reviewed periodically and should reflect evidence-based practice...
  100. doi Pain in patients with lung cancer: pathophysiology and treatment
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo 312, 90145 Palermo, Italy
    Lung Cancer 68:10-5. 2010
    ..More complex strategies, such as interventional procedures, are seldom necessary and require an appropriate selection of patients...
  101. ncbi A model of acute symptom control unit: Pain Relief and Palliative Care Unit of La Maddalena Cancer Center
    Sebastiano Mercadante
    Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Via San Lorenzo Colli 312, 90146 Palermo, Italy
    Support Care Cancer 11:114-9. 2003
    ....