Guido Lucarelli

Summary

Affiliation: Mediterranean Institute of Hematology
Country: Italy

Publications

  1. ncbi request reprint Reversibility of cirrhosis in patients cured of thalassemia by bone marrow transplantation
    Pietro Muretto
    Unita Operativa di Anatomia Patologica, Azienda Ospedaliera San Salvatore di Pesaro, 6110 Pesaro, Italy
    Ann Intern Med 136:667-72. 2002
  2. ncbi request reprint Stem cell transplantation for hemoglobinopathies
    Javid Gaziev
    Hematology Oncology Department and Bone Marrow Transplantation Center, Azienda Ospedaliera San Salvatore di Pesaro, Italy
    Curr Opin Pediatr 15:24-31. 2003
  3. ncbi request reprint Advances in the allogeneic transplantation for thalassemia
    Guido Lucarelli
    International Centre for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Rome 00133, Italy
    Blood Rev 22:53-63. 2008
  4. pmc Hematopoietic stem cell transplantation in thalassemia and sickle cell anemia
    Guido Lucarelli
    International Center for Transplantation in Thalassemia and Sickle Cell Anemia Mediterranean Institute of Hematology, Policlinic of the University of Rome Tor Vergata, Tor Vergata, Italy
    Cold Spring Harb Perspect Med 2:a011825. 2012
  5. doi request reprint Allogeneic cellular gene therapy in hemoglobinopathies--evaluation of hematopoietic SCT in sickle cell anemia
    G Lucarelli
    International Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinic of the University of Rome Tor Vergata, Rome, Italy
    Bone Marrow Transplant 47:227-30. 2012
  6. doi request reprint Immunohematologic reconstitution in pediatric patients after T cell-depleted HLA-haploidentical stem cell transplantation for thalassemia
    Antonella Isgro
    International Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinico Tor Vergata, Rome, Italy
    Biol Blood Marrow Transplant 16:1557-66. 2010
  7. doi request reprint Bone marrow transplantation for thalassemia from alternative related donors: improved outcomes with a new approach
    Javid Gaziev
    International Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinico Tor Vergata, Rome, Italy
    Blood 122:2751-6. 2013
  8. ncbi request reprint Bone marrow transplantation in adults with thalassemia: Treatment and long-term follow-up
    Javid Gaziev
    Mediterranean Institute of Hematology, International Center for Transplantation in Thalassemia and Sickle Cell Anemia, Policlinico Tor Vergata, Rome, Italy
    Ann N Y Acad Sci 1054:196-205. 2005
  9. doi request reprint Optimization of the immunomagnetic selection in microcythemic donors enrolled for haploidentical transplantation
    Maria Cristina Scerpa
    Immunohematology Section, Tor Vergata University and CryoLab Stem Cells Manipulation and Cryopreservation Laboratory, Rome, Italy
    Transfus Apher Sci 48:263-9. 2013
  10. doi request reprint Progress in hematopoietic stem cell transplantation as allogeneic cellular gene therapy in thalassemia
    Antonella Isgro
    International Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinic of the University of Rome Tor Vergata, Viale Oxford, Rome, Italy
    Ann N Y Acad Sci 1202:149-54. 2010

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Reversibility of cirrhosis in patients cured of thalassemia by bone marrow transplantation
    Pietro Muretto
    Unita Operativa di Anatomia Patologica, Azienda Ospedaliera San Salvatore di Pesaro, 6110 Pesaro, Italy
    Ann Intern Med 136:667-72. 2002
    ..Cirrhosis is a well-known complication of thalassemia major. In this context, it is a consequence of iron overload and hepatitis C virus infection and generally seems to be irreversible...
  2. ncbi request reprint Stem cell transplantation for hemoglobinopathies
    Javid Gaziev
    Hematology Oncology Department and Bone Marrow Transplantation Center, Azienda Ospedaliera San Salvatore di Pesaro, Italy
    Curr Opin Pediatr 15:24-31. 2003
    ..This review summarizes the current status of stem cell transplantation for hemoglobinopathies...
  3. ncbi request reprint Advances in the allogeneic transplantation for thalassemia
    Guido Lucarelli
    International Centre for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Rome 00133, Italy
    Blood Rev 22:53-63. 2008
    ..Ex-thalassemics still carry the clinical complications acquired during years of transfusion and chelation therapy. Longer follow-up and management of these complications in ex-thalassemics are essential...
  4. pmc Hematopoietic stem cell transplantation in thalassemia and sickle cell anemia
    Guido Lucarelli
    International Center for Transplantation in Thalassemia and Sickle Cell Anemia Mediterranean Institute of Hematology, Policlinic of the University of Rome Tor Vergata, Tor Vergata, Italy
    Cold Spring Harb Perspect Med 2:a011825. 2012
    ..Novel non-myeloablative transplantation protocols could make HSCT available to adult SCA patients who were previously excluded from allogeneic stem cell transplantation...
  5. doi request reprint Allogeneic cellular gene therapy in hemoglobinopathies--evaluation of hematopoietic SCT in sickle cell anemia
    G Lucarelli
    International Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinic of the University of Rome Tor Vergata, Rome, Italy
    Bone Marrow Transplant 47:227-30. 2012
    ..In conclusion, these data confirm SCT from a suitable HLA-matched, related donor should become the primary option for curing children with SCA. There is an excellent survival rate and a return to normal life, free of SCA-related events...
  6. doi request reprint Immunohematologic reconstitution in pediatric patients after T cell-depleted HLA-haploidentical stem cell transplantation for thalassemia
    Antonella Isgro
    International Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinico Tor Vergata, Rome, Italy
    Biol Blood Marrow Transplant 16:1557-66. 2010
    ..NNK subset analysis might be useful for determining transplant outcome...
  7. doi request reprint Bone marrow transplantation for thalassemia from alternative related donors: improved outcomes with a new approach
    Javid Gaziev
    International Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinico Tor Vergata, Rome, Italy
    Blood 122:2751-6. 2013
    ..The present data show that the Pc 26.1 preparative regimen allows thalassemia patients to safely undergo BMT from RDs who are not HLA-matched siblings, with transplant outcomes similar to patients with MSD grafts. ..
  8. ncbi request reprint Bone marrow transplantation in adults with thalassemia: Treatment and long-term follow-up
    Javid Gaziev
    Mediterranean Institute of Hematology, International Center for Transplantation in Thalassemia and Sickle Cell Anemia, Policlinico Tor Vergata, Rome, Italy
    Ann N Y Acad Sci 1054:196-205. 2005
    ..Although this new approach to transplant adult patients with a reduced-dose intensity-conditioning regimen has improved thalassemia-free survival, transplant-related mortality in these high-risk patients remains elevated...
  9. doi request reprint Optimization of the immunomagnetic selection in microcythemic donors enrolled for haploidentical transplantation
    Maria Cristina Scerpa
    Immunohematology Section, Tor Vergata University and CryoLab Stem Cells Manipulation and Cryopreservation Laboratory, Rome, Italy
    Transfus Apher Sci 48:263-9. 2013
    ..Immunomagnetic cell selection (ICS) cells is increasingly used in allogeneic hematopoietic transplantation in order to reduce the T cells quantity. The aim of this study was to evaluate an protocol based on Ficoll method before ICS...
  10. doi request reprint Progress in hematopoietic stem cell transplantation as allogeneic cellular gene therapy in thalassemia
    Antonella Isgro
    International Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinic of the University of Rome Tor Vergata, Viale Oxford, Rome, Italy
    Ann N Y Acad Sci 1202:149-54. 2010
    ..Patients who do not have matched family or unrelated donors could benefit from haploidentical mother-to-child transplantation. Overall, the results of this type of transplantation appear encouraging...
  11. ncbi request reprint Novel pharmacokinetic behavior of intravenous busulfan in children with thalassemia undergoing hematopoietic stem cell transplantation: a prospective evaluation of pharmacokinetic and pharmacodynamic profile with therapeutic drug monitoring
    Javid Gaziev
    International Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinico Tor Vergata, Rome, Italy
    Blood 115:4597-604. 2010
    ....
  12. doi request reprint Purified T-depleted, CD34+ peripheral blood and bone marrow cell transplantation from haploidentical mother to child with thalassemia
    Pietro Sodani
    International Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinico Tor Vergata, Rome, Italy
    Blood 115:1296-302. 2010
    ..These results suggest that maternal haploidentical hematopoietic stem cell transplantation is feasible in patients with thalassemia who lack a matched related donor...
  13. doi request reprint Positive immunomagnetic CD34(+) cell selection in haplo-identical transplants in beta-thalassemia patients: removal of platelets using an automated system
    Francesco Zinno
    Immunohematology Section, Tor Vergata University and SIMT Bambino Gesù Pediatric Hospital, Rome, Italy
    Cytotherapy 12:60-6. 2010
    ....
  14. doi request reprint Late-onset hemorrhagic cystitis in children after hematopoietic stem cell transplantation for thalassemia and sickle cell anemia: a prospective evaluation of polyoma (BK) virus infection and treatment with cidofovir
    Javid Gaziev
    International Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinico Tor Vergata, Rome, Italy
    Biol Blood Marrow Transplant 16:662-71. 2010
    ..Randomized clinical trials are urgently needed to better define the role of CDV in treating BK virus-related HC...
  15. doi request reprint Cell processing for haplo-identical hematopoietic stem cell transplantation: automated washing and immunomagnetic-positive selection
    Maria Cristina Scerpa
    Immunohematology Section, Tor Vergata University, CryoLab and Stem Cells Manipulation and Cryopreservation Laboratory, IRCCS Bambino Gesù Pediatric Hospital, Rome, Italy
    Cytotherapy 14:811-7. 2012
    ..The aim of this study was to evaluate an automated washing protocol before immunomagnetic selection...
  16. doi request reprint Allogeneic cellular gene therapy for hemoglobinopathies
    Javid Gaziev
    International Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinico Tor Vergata, Viale Oxford 81, Rome, Italy
    Hematol Oncol Clin North Am 24:1145-63. 2010
    ..Patients who lack a matched related or unrelated donor can now benefit from successful transplantation using haploidentical donors...
  17. doi request reprint The impact of hematopoietic stem cell transplantation on the management of thalassemia
    Antonella Isgro
    International Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinic of the University of Rome Tor Vergata, Viale Oxford 81, Rome, Italy
    Expert Rev Hematol 2:335-44. 2009
    ..Therefore, when an HLA-identical donor is present, the transplantation of allogeneic stem cells should be performed as allogeneic gene therapy...
  18. pmc Type 1 regulatory T cells are associated with persistent split erythroid/lymphoid chimerism after allogeneic hematopoietic stem cell transplantation for thalassemia
    Giorgia Serafini
    Mediterranean Institute of Hematology, IME Foundation, Policlinico di Tor Vergata, Rome, Italy
    Haematologica 94:1415-26. 2009
    ..Persistent mixed chimerism develops in around 10% of transplanted thalassemic patients, but the biological mechanisms underlying this phenomenon are poorly understood...
  19. pmc Quantitatively different red cell/nucleated cell chimerism in patients with long-term, persistent hematopoietic mixed chimerism after bone marrow transplantation for thalassemia major or sickle cell disease
    Marco Andreani
    Laboratorio di Immunogenetica e Biologia dei Trapianti, Fondazione IME, Policlinico Tor Vergata, Viale Oxford 81, 00133 Rome, Italy
    Haematologica 96:128-33. 2011
    ..Results were compared with the engraftment state observed in singly picked out burst-forming unit - erythroid colonies and in the nucleated cells collected from the peripheral blood and from the bone marrow...
  20. ncbi request reprint Stem cell transplantation and gene therapy for hemoglobinopathies
    Javid Gaziev
    Mediterranean Institute of Hematology, Rome, Italy
    Curr Hematol Rep 4:126-31. 2005
    ..This review focuses on the current status of stem cell transplantation for hemoglobinopathies...
  21. pmc Hematopoietic stem cell transplantation in thalassemia and sickle cell disease. Unicenter experience in a multi-ethnic population
    Marco Marziali
    International Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Rome Italy
    Mediterr J Hematol Infect Dis 1:e2009027. 2009
    ..The Rome experience of SCT in patients with thalassemia and sickle cell anemia confirmed the results obtained in Pesaro, and most importantly showed the reproducibility of these results in other centers...
  22. ncbi request reprint Hematopoietic stem cell transplantation for thalassemia
    Javid Gaziev
    International Center for Transplantation in Thalassemia and Sickle Cell Anemia, Mediterranean Institute of Hematology, Policlinico Tor Vergata Viale Oxford 81, 00133 Rome, Italy
    Curr Stem Cell Res Ther 6:162-9. 2011
    ..Most ex-thalassemics continue to have disease and treatment-related complications acquired before transplantation which require adequate treatment following BMT...
  23. ncbi request reprint Stem cell transplantation for thalassaemia
    Javid Gaziev
    Mediterranean Institute of Hematology, International Centre for Transplantation in Thalassemia and Sickle Cell Anemia, Azienda Ospedaliera San Camillo, Forlanini di Roma, Italy
    Reprod Biomed Online 10:111-5. 2005
    ..The results of transplant in adult patients treated with current protocols are less successful. This study reports experience with BMT for thalassaemia...
  24. ncbi request reprint New approach for bone marrow transplantation in patients with class 3 thalassemia aged younger than 17 years
    Pietro Sodani
    Mediterranean Institute of Hematology, 00152 Rome, Italy
    Blood 104:1201-3. 2004
    ..The incidence of recurrent thalassemia after the transplantation decreased from 30% to 8%...
  25. ncbi request reprint Excretion of the novel polyomaviruses KI and WU in the stool of patients with hematological disorders
    Muhammed Babakir-Mina
    Laboratory of Molecular Virology, University Hospital Tor Vergata, Viale Oxford, Rome, Italy
    J Med Virol 81:1668-73. 2009
    ..The novel polyomaviruses KI and WU may have a pathogenic role in immunocompromised patients...
  26. pmc Relationship between mixed chimerism and rejection after bone marrow transplantation in thalassaemia
    Marco Andreani
    Laboratorio di Immunogenetica e Biologia dei Trapianti, Fondazione IME, Roma, Italy
    Blood Transfus 6:143-9. 2008
    ..Complete donor haematopoiesis is not essential for sustained engraftment and the simultaneous presence of haematopoietic cells of both donor and recipient origin is not a rare event after a transplant...
  27. ncbi request reprint Effects of iron overload and hepatitis C virus positivity in determining progression of liver fibrosis in thalassemia following bone marrow transplantation
    Emanuele Angelucci
    Unità Operativa di Ematologia e Centro Trapianto di Midollo Osseo di Muraglia, Azienda Ospedale di Pesaro, Italy
    Blood 100:17-21. 2002
    ..Thus, iron overload and HCV infection are independent risk factors for liver fibrosis progression, and their concomitant presence results in a striking increase in risk...
  28. ncbi request reprint Unrelated donor bone marrow transplantation for thalassemia: the effect of extended haplotypes
    Giorgio La Nasa
    Centro Trapianti Midollo Osseo, Ospedale Binaghi Cattedra di Genetica Medica, and the Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Cagliari, Italy
    Blood 99:4350-6. 2002
    ..BMT from well-selected unrelated donors may offer results comparable to those obtained in transplantations using HLA-identical family donors, especially for patients with lesser iron overload...
  29. ncbi request reprint Enhanced macrophagic attack on beta-thalassemia major erythroid precursors
    Emanuele Angelucci
    Unità Operativa Ematologia e Centro Trapianti Midollo Osseo, Azienda Ospedale di Pesaro, Pesaro, Italy
    Haematologica 87:578-83. 2002
    ..Thus, increased apoptosis and perhaps other features of thalassemic erythroid precursors might be the cause of their enhanced phagocytic removal...