Roberta Mazzucchelli

Summary

Country: Italy

Publications

  1. ncbi request reprint IgG4-related sclerosing disease: an emerging entity frequently misdiagnosed
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Anal Quant Cytol Histol 35:189-96. 2013
  2. ncbi request reprint Clinicopathological significance of lymphovascular invasion in urothelial carcinoma
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Anal Quant Cytol Histol 34:173-9. 2012
  3. ncbi request reprint Comparison between incidentally and clinically detected prostate cancer: implications for prostate cancer screening programs and focal therapy
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Anal Quant Cytol Histol 32:151-4. 2010
  4. ncbi request reprint alpha-Methylacyl coenzyme A racemase, Ki-67, and topoisomerase IIalpha in cystoprostatectomies with incidental prostate cancer
    Alfredo Santinelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Am J Clin Pathol 128:657-66. 2007
  5. ncbi request reprint HER2 expression and gene amplification in pT2a Gleason score 6 prostate cancer incidentally detected in cystoprostatectomies: comparison with clinically detected androgen-dependent and androgen-independent cancer
    Rodolfo Montironi
    Section of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, School of Medicine, I 60020 Torrette, Ancona, Italy
    Hum Pathol 37:1137-44. 2006
  6. doi request reprint Immunohistochemical expression of somatostatin receptor subtypes in prostate tissue from cystoprostatectomies with incidental prostate cancer
    Doriana Morichetti
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    BJU Int 106:1072-80. 2010
  7. doi request reprint Immunohistochemical expression of prostate tumour overexpressed 1 (PTOV1) in atypical adenomatous hyperplasia (AAH) of the prostate: additional evidence linking (AAH) to adenocarcinoma
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Torrette, Ancona, Italy
    Cell Oncol (Dordr) 36:37-42. 2013
  8. doi request reprint Immunohistochemical expression of prostate tumor overexpressed 1 in cystoprostatectomies with incidental and insignificant prostate cancer. Further evidence for field effect in prostatic carcinogenesis
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, 60126 Ancona, Italy
    Hum Pathol 42:1931-6. 2011
  9. ncbi request reprint Prediction of prostatic involvement by urothelial carcinoma in radical cystoprostatectomy for bladder cancer
    Roberta Mazzucchelli
    Polytechnic University of the Marche Region School of Medicine, United Hospitals, Ancona, Italy
    Urology 74:385-90. 2009
  10. ncbi request reprint Strong immunohistochemical expression of fibroblast growth factor receptor 3, superficial staining pattern of cytokeratin 20, and low proliferative activity define those papillary urothelial neoplasms of low malignant potential that do not recur
    Francesca Barbisan
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Cancer 112:636-44. 2008

Collaborators

Detail Information

Publications67

  1. ncbi request reprint IgG4-related sclerosing disease: an emerging entity frequently misdiagnosed
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Anal Quant Cytol Histol 35:189-96. 2013
    ..In fact, an increased ability to recognize the characteristic features of IgG4-related sclerosing disease would play an extremely important role in avoiding unnecessary surgery in favor of initiating corticosteroid therapy...
  2. ncbi request reprint Clinicopathological significance of lymphovascular invasion in urothelial carcinoma
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Anal Quant Cytol Histol 34:173-9. 2012
    ..Routine use of immunohistochemistry for endothelium as a screening test in all cases cannot be recommended...
  3. ncbi request reprint Comparison between incidentally and clinically detected prostate cancer: implications for prostate cancer screening programs and focal therapy
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Anal Quant Cytol Histol 32:151-4. 2010
    ....
  4. ncbi request reprint alpha-Methylacyl coenzyme A racemase, Ki-67, and topoisomerase IIalpha in cystoprostatectomies with incidental prostate cancer
    Alfredo Santinelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Am J Clin Pathol 128:657-66. 2007
    ..Our findings in marker expression in NEp, atrophy, and HPIN suggest that there are some differences in the field effects in terms of prostatic carcinogenesis between CyP and RP specimens...
  5. ncbi request reprint HER2 expression and gene amplification in pT2a Gleason score 6 prostate cancer incidentally detected in cystoprostatectomies: comparison with clinically detected androgen-dependent and androgen-independent cancer
    Rodolfo Montironi
    Section of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, School of Medicine, I 60020 Torrette, Ancona, Italy
    Hum Pathol 37:1137-44. 2006
    ..This may contribute to a better understanding of the results obtained in screening programs where insignificant cancers are detected along with clinically significant cancers...
  6. doi request reprint Immunohistochemical expression of somatostatin receptor subtypes in prostate tissue from cystoprostatectomies with incidental prostate cancer
    Doriana Morichetti
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    BJU Int 106:1072-80. 2010
    ..To examine immunohistochemically the expression of the five somatostatin receptors (SSTRs) in cystoprostatectomies (CyPs) with incidental prostate cancer...
  7. doi request reprint Immunohistochemical expression of prostate tumour overexpressed 1 (PTOV1) in atypical adenomatous hyperplasia (AAH) of the prostate: additional evidence linking (AAH) to adenocarcinoma
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Torrette, Ancona, Italy
    Cell Oncol (Dordr) 36:37-42. 2013
    ..It has been suggested that overexpression of PTOV1 can contribute to the proliferative status of prostate tumour cells and thus to their biological behaviour...
  8. doi request reprint Immunohistochemical expression of prostate tumor overexpressed 1 in cystoprostatectomies with incidental and insignificant prostate cancer. Further evidence for field effect in prostatic carcinogenesis
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, 60126 Ancona, Italy
    Hum Pathol 42:1931-6. 2011
    ....
  9. ncbi request reprint Prediction of prostatic involvement by urothelial carcinoma in radical cystoprostatectomy for bladder cancer
    Roberta Mazzucchelli
    Polytechnic University of the Marche Region School of Medicine, United Hospitals, Ancona, Italy
    Urology 74:385-90. 2009
    ..To ascertain which variables of bladder urothelial carcinoma (UC) might be useful in predicting either UC involving the prostate (UCP) or incidental prostate adenocarcinoma in radical cystoprostatectomy specimens...
  10. ncbi request reprint Strong immunohistochemical expression of fibroblast growth factor receptor 3, superficial staining pattern of cytokeratin 20, and low proliferative activity define those papillary urothelial neoplasms of low malignant potential that do not recur
    Francesca Barbisan
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Cancer 112:636-44. 2008
    ..The objective of the current study was to evaluate immunohistochemically tissue expression of fibroblast growth factor receptor 3 (FGFR3), cytokeratin 20 (CK20), and MIB-1 in nonrecurrent and recurrent PUNLMP...
  11. doi request reprint Immunohistochemical expression and localization of somatostatin receptor subtypes in androgen ablated prostate cancer
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Torrette, Ancona, Italy
    Cell Oncol (Dordr) 34:235-43. 2011
    ....
  12. doi request reprint Urothelial and incidental prostate carcinoma in prostates from cystoprostatectomies for bladder cancer: is there a relationship between urothelial and prostate cancer?
    Francesca Barbisan
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    BJU Int 103:1058-63. 2009
    ..To determine the incidence and features of urothelial carcinoma (UC) involving the prostate (UCP) and of prostate adenocarcinoma (PA) in radical cystoprostatectomy (RCP) for bladder cancer...
  13. doi request reprint Overexpression of ELAV-like protein HuR is associated with increased COX-2 expression in atrophy, high-grade prostatic intraepithelial neoplasia, and incidental prostate cancer in cystoprostatectomies
    Francesca Barbisan
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Eur Urol 56:105-12. 2009
    ..The human ELAV-like protein HuR regulates the stability of several mRNA targets, including that of cyclooygenase-2 (COX-2). Their expression in prostatic carcinogenesis is uncertain...
  14. pmc Search for residual prostate cancer on pT0 radical prostatectomy after positive biopsy
    Roberta Mazzucchelli
    Section of Pathological Anatomy and Histopathology, School of Medicine, United Hospitals, Polytechnic University of the Marche Region Ancona, I 60020 Torrette, Ancona, Italy
    Virchows Arch 450:371-8. 2007
    ..If a block is missing part of the peripheral zone (capsular incision), this should be commented on. DNA analysis for tissue identity should be performed when the other steps have been taken without finding cancer...
  15. doi request reprint Is incidentally detected prostate cancer in patients undergoing radical cystoprostatectomy clinically significant?
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Am J Clin Pathol 131:279-83. 2009
    ..5 cc, 116 (94.3%). Of the 123 incidentally detected cases of PCa, 100 (81.3%) were considered clinically insignificant. Incidentally detected PCa is frequently observed in RCP. The majority are clinically insignificant...
  16. ncbi request reprint Immunohistochemical expression of endothelin-1 and endothelin-A and endothelin-B receptors in high-grade prostatic intraepithelial neoplasia and prostate cancer
    Rodolfo Montironi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, Ancona, Italy
    Eur Urol 52:1682-9. 2007
    ..High-grade prostatic intraepithelial neoplasia (HGPIN) was also investigated...
  17. ncbi request reprint Chromatin phenotype karyometry can predict recurrence in papillary urothelial neoplasms of low malignant potential
    Rodolfo Montironi
    Section of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, Ancona, Italy
    Cell Oncol 29:47-58. 2007
    ..Pathol. 57(2004), 1201-1207) had shown that a karyometric assessment of nuclei from papillary urothelial neoplasms of low malignant potential (PUNLMP) revealed subtle differences in phenotype which correlated with recurrence of disease...
  18. pmc Somatostatin receptor subtypes in hormone-refractory (castration-resistant) prostatic carcinoma
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona 60126, Italy
    Asian J Androl 13:242-7. 2011
    ..In conclusion, this study expands our knowledge on the expression and localisation of five SSTRs in the various tissue components in the HR PCa compared with hormone-sensitive PCa...
  19. doi request reprint Immunohistochemical expression and localization of somatostatin receptor subtypes in androgen ablated prostate cancer
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Anal Cell Pathol (Amst) 33:27-36. 2010
    ....
  20. ncbi request reprint Mechanisms of disease: high-grade prostatic intraepithelial neoplasia and other proposed preneoplastic lesions in the prostate
    Rodolfo Montironi
    Uropathology Section, Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region Ancona, School of Medicine, United Hospitals, Torrette, Ancona, Italy
    Nat Clin Pract Urol 4:321-32. 2007
    ....
  21. doi request reprint A randomized phase IIb presurgical study of finasteride vs. low-dose flutamide vs. placebo in men with prostate cancer. Efficacy monitored by karyometry
    Rodolfo Montironi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Urol Oncol 31:557-65. 2013
    ..The aim of the study was to explore karyometry as a method for monitoring the efficacy of intervention with preventive agents in patients with CaP...
  22. ncbi request reprint Chromosomal abnormalities in macroscopically normal urothelium in patients with bladder pT1 and pT2a urothelial carcinoma: a fluorescence in situ hybridization study and correlation with histologic features
    Roberta Mazzucchelli
    Section of Pathological Anatomy and Histopathology, School of Medicine, Polytechnic University of the Marche Region Ancona, Ancona, Italy
    Anal Quant Cytol Histol 27:143-51. 2005
    ..To analyze chromosomal abnormalities in macroscopically normal urothelium in patients with bladder pT1 and pT2a urothelial carcinoma and correlate the changes with histologic features...
  23. doi request reprint Expression of prostate stem cell antigen in high-grade prostatic intraepithelial neoplasia and prostate cancer
    Francesca Barbisan
    Section of Pathological Anatomy, United Hospitals and Polytechnic University of the Marche Region, School of Medicine, Ancona, Italy
    Histopathology 57:572-9. 2010
    ..To investigate prostate stem cell antigen (PSCA) and Ki-67 expression in normal-looking epithelium (NEp), atrophy, high-grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma (PCa)...
  24. ncbi request reprint Pathology of prostate cancer and focal therapy ('male lumpectomy')
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, I 60 126 Torrette, Ancona, Italy
    Anticancer Res 29:5155-61. 2009
    ....
  25. doi request reprint The spectrum of morphology in non-neoplastic prostate including cancer mimics
    Rodolfo Montironi
    Section of Pathological Anatomy, Polytechnic University of Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Histopathology 60:41-58. 2012
    ..Diagnostic awareness of the salient histomorphological and relevant immunohistochemical features of these prostatic pseudoneoplasms is critical to avoid rendering false positive diagnoses of malignancy...
  26. ncbi request reprint Incidentally detected prostate cancer in cystoprostatectomies: pathological and morphometric comparison with clinically detected cancer in totally embedded specimens
    Rodolfo Montironi
    Polytechnic University of the Marche Region, School of Medicine, Umberto I Hospital, Torrette, Ancona, Italy
    Hum Pathol 36:646-54. 2005
    ..We conclude that incidentally detected cancer is less aggressive than clinically detected cancer...
  27. doi request reprint Solitary fibrous tumour of the prostate identified on needle biopsy
    Andrea B Galosi
    Urology Institute, Polytechnic University of the Marche Region, Azienda Ospedaliero Universitaria, Ancona, Italy
    Eur Urol 56:564-7. 2009
    ..Owing to their relative rarity and lack of long-term follow-up, the clinical behaviour of prostatic SFTs is difficult to predict. Complete resection of the tumour is currently the single main prognostic factor...
  28. doi request reprint Rare and unusual histological variants of prostatic carcinoma: clinical significance
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    BJU Int 102:1369-74. 2008
    ..They are usually aggressive tumours that often present with secondary deposits. The outcome is generally poor. Only basal cell carcinoma is seen as a low-grade carcinoma...
  29. ncbi request reprint Recurrent papillary urothelial neoplasm of low malignant potential. Subtle architectural disorder detected by quantitative analysis in DAXX-immunostained tissue sections
    Paolo Castellini
    Department of Industrial Engineering and Mathematical Sciences DIISM, Polytechnic University of the Marche Region, Ancona 60020, Italy
    Hum Pathol 45:745-52. 2014
    ..Such finding can be used routinely to identify those PUNLMP patients who will have recurrence. ..
  30. pmc How much do you know about benign, preneoplastic, non-invasive and invasive neoplastic lesions of the urinary bladder classified according to the 2004 WHO scheme?
    Rodolfo Montironi
    Section of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region Ancona, Ancona, Italy
    Diagn Pathol 6:31. 2011
    ..This paper is directed to all who are involved with the application of this classification at the anticancer research, diagnostic, prognostic and therapeutic levels, in particular to uropathologists, urologists and oncologists...
  31. doi request reprint Prostatic intraepithelial neoplasia: its morphological and molecular diagnosis and clinical significance
    Rodolfo Montironi
    Institute of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region Ancona, United Hospitals, Ancona, Italy
    BJU Int 108:1394-401. 2011
    ..Some recent studies have suggested that molecular findings associated with HGPIN might be able to predict which men are more likely to have cancer on re-biopsy...
  32. doi request reprint Secondary neoplasms of the urinary system and male genital organs
    Doriana Morichetti
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    BJU Int 104:770-6. 2009
    ....
  33. pmc Macrocryosectioning and complete sampling of the prostate in a potential multiorgan donor candidate
    Roberta Mazzucchelli
    Unit of Pathological Anatomy, United Hospitals and Polytechnic University of the Marche Region, Ancona, Italy
    J Clin Pathol 60:951-2. 2007
  34. doi request reprint Neuroendocrine tumours of the urinary system and male genital organs: clinical significance
    Roberta Mazzucchelli
    Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    BJU Int 103:1464-70. 2009
    ..Both show the morphology and immunophenotype of NE carcinoma originating in other organs. Although the occurrence is rare, it is highly aggressive...
  35. ncbi request reprint Decision support systems for morphology-based diagnosis and prognosis of prostate neoplasms: a methodological approach
    Rodolfo Montironi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Cancer 115:3068-77. 2009
    ..This has had a significant impact on our capability to derive diagnostic and prognostic information from histopathological material with prostate neoplasms. Cancer 2009;115(13 suppl):3068-77. (c) 2009 American Cancer Society...
  36. ncbi request reprint Immunohistochemical detection and localization of somatostatin receptor subtypes in prostate tissue from patients with bladder outlet obstruction
    Rodolfo Montironi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Cell Oncol 30:473-82. 2008
    ..6% of the endothelial cells. With subtypes 3 and 4 the greatest proportion of cells showed a weak intensity (73.5 and 56.4%, respectively). With the subtype 2 and 5 the majority of cells were negative (59.1 and 50.7%, respectively)...
  37. ncbi request reprint Histopathology reporting of prostate needle biopsies. 2005 update
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region Ancona, School of Medicine, United Hospitals, Via Conca 71, 60020 Torrette, Ancona, Italy
    Virchows Arch 449:1-13. 2006
    ....
  38. ncbi request reprint Immunohistochemical evaluation of urokinase plasminogen activator receptor in noninvasive and early invasive urothelial papillary neoplasia
    Caterina Vivani
    Institute of Urology, Laboratory of Cellular and Molecular Biology, Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, Ancona, Via Tronto 10 A, 60020 Ancona, Italy
    Anal Quant Cytol Histol 26:15-21. 2004
    ..To investigate urokinase plasminogen activator receptor (uPAR) expression in urothelial papilloma and in noninvasive and early invasive papillary carcinoma...
  39. ncbi request reprint Karyometry detects subvisual differences in chromatin organization state between cribriform and flat high-grade prostatic intraepithelial neoplasia
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, Ancona, Italy
    Mod Pathol 17:928-37. 2004
    ....
  40. ncbi request reprint Active surveillance for low-risk prostate cancer
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Anticancer Res 30:3683-92. 2010
    ....
  41. ncbi request reprint Cystic nephroma and mixed epithelial and stromal tumour of the kidney: opposite ends of the spectrum of the same entity?
    Rodolfo Montironi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Eur Urol 54:1237-46. 2008
    ..Our aim was to review the broad spectrum of usual and unusual clinical and morphologic findings observed in CN and MEST...
  42. ncbi request reprint Atypical foci suspicious but not diagnostic of malignancy in prostate needle biopsies (also referred to as "atypical small acinar proliferation suspicious for but not diagnostic of malignancy")
    Rodolfo Montironi
    Pathology, Marche Polytechnic University, Ancona, Italy
    Eur Urol 50:666-74. 2006
    ..To review atypical focus suspicious but not diagnostic of malignancy in needle biopsies of the prostate, also referred to as "atypical small acinar proliferation suspicious for but not diagnostic of malignancy."..
  43. ncbi request reprint Gleason grading of prostate carcinoma in needle biopsies vs. radical prostatectomy specimens
    Roberta Mazzucchelli
    Section of Pathological Anatomy and Histopathology, Institute of Urology, School of Medicine, Polytechnic University of the Marche Region, Ancona, Italy
    Anal Quant Cytol Histol 27:125-33. 2005
    ..Several sources of discrepancy between these 2 types of specimen have been identified. Further educational endeavors are needed to arrive at a greater consensus and accuracy in the use of the Gleason system...
  44. pmc Adult primary paratesticular mesenchymal tumors with emphasis on a case presentation and discussion of spermatic cord leiomyosarcoma
    Andrea B Galosi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, I 60126 Torrette, Ancona, Italy
    Diagn Pathol 9:90. 2014
    ..In adults, more than 75% of these lesions arise from the spermatic cord, 20% being leiomyosarcoma. Tumor grade, stage, histologic type, and lymph node involvement are independently predictive of prognosis...
  45. ncbi request reprint Spectrum of prostatic nonepithelial tumors and tumorlike conditions with spindle cell features
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Anal Quant Cytol Histol 34:139-44. 2012
    ..The utility of ancillary studies, including immunohistochemistry, is often limited and the main criteria for diagnosis are the morphologic findings by routine hematoxylin and eosin stain...
  46. ncbi request reprint Classification and grading of noninvasive and invasive neoplasms of the urothelium
    Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
    Anal Quant Cytol Histol 34:111-9. 2012
    ..However, some controversies on the precise criteria and terminology, especially when the papillary lesions are concerned, are still present...
  47. ncbi request reprint 2005 update on pathology of prostate biopsies with cancer
    Rodolfo Montironi
    Pathology, Polytechnic University, Ancona, Italy
    Eur Urol 49:441-7. 2006
    ..To review the diagnostic and prognostic importance of pathologic findings in prostate biopsies...
  48. ncbi request reprint Molecular mechanisms in prostate cancer. A review
    Roberta Mazzucchelli
    Section of Pathological Anatomy and Histopathology, School of Medicine, Polytechnic University of the Marche Region, Azienda Ospedaliera Umberto Io, I 60020 Torrette, Ancona, Italy
    Anal Quant Cytol Histol 26:127-33. 2004
    ..1, PTEN and p27) and androgens as critical determinants of the phenotype of PCa cells and defines specific targets for detection, diagnosis and treatment of PCa...
  49. doi request reprint Upregulation of tissue and urinary nicotinamide N-methyltransferase in bladder cancer: potential for the development of a urine-based diagnostic test
    Davide Sartini
    Section of Biochemistry, Department of Clinical Sciences, Polytechnic University of Marche, Via Ranieri 65, 60131, Ancona, Italy
    Cell Biochem Biophys 65:473-83. 2013
    ..Our results indicate that a marked NNMT increase is a peculiar feature of bladder UC and suggest the potential suitability of urine NNMT expression levels determination for early and non-invasive diagnosis of bladder cancer...
  50. pmc Immunohistochemical analysis of chromatin remodeler DAXX in high grade urothelial carcinoma
    Antonio Zizzi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, 60126, Torrette Ancona, Italy
    Diagn Pathol 8:111. 2013
    ..The aim of this exploratory immunohistochemical study was to evaluate DAXX protein expression in high grade invasive urothelial carcinoma (UC) of the bladder as a biological regulator of aggressiveness...
  51. ncbi request reprint Morphological assessment of radical prostatectomy specimens. A protocol with clinical relevance
    Rodolfo Montironi
    Institute of Pathological Anatomy, University of Ancona School of Medicine, Umberto 1 degrees Hospital, 60020, Torrette, Ancona, Italy
    Virchows Arch 442:211-7. 2003
    ..The pathology report should include relevant clinical information as well as provide prognostically useful information derived from the macroscopic examination and microscopic evaluation of the RP specimen..
  52. pmc Handling of radical prostatectomy specimens: total embedding with large-format histology
    Rodolfo Montironi
    Section of Pathological Anatomy, School of Medicine, United Hospitals, Polytechnic University of the Marche Region, 60126 Ancona, Italy
    Int J Breast Cancer 2012:932784. 2012
    ..There are reasons in favour and a few drawbacks. Its implementation does not require an additional amount of work from the technicians' side. It gives further clinical significance to our work of uropathologists...
  53. ncbi request reprint Urothelial changes induced by therapeutic procedures for bladder cancer. A review
    Roberta Mazzucchelli
    Section of Pathologic Anatomy and Histopathology and Institute of Urology, School of Medicine, Polytechnic University of the Marche Region, Ancona, Italy
    Anal Quant Cytol Histol 27:27-34. 2005
    ..Pathologists must be aware that following these types of treatment, the clinical utility of urinary cytology is reduced...
  54. ncbi request reprint HER-2 expression and gene amplification in high-grade PIN and prostate cancer
    Rodolfo Montironi
    Section of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, School of Medicine, Ancona, Italy
    Arch Ital Urol Androl 78:135-9. 2006
    ..5%). A statistically significant difference in the number of cases with both overexpression and amplification was only seen between CyP and hormone-independent cancers (p = 0.007)...
  55. ncbi request reprint Evaluation of prognostic factors in radical prostatectomy specimens with cancer
    Roberta Mazzucchelli
    Institute of Pathological Anatomy, University of Ancona School of Medicine, Ancona, Italy
    Urol Int 68:209-15. 2002
    ..The goal is to tailor the therapeutic approach to the clinical, morphological and molecular features of each patient...
  56. ncbi request reprint Prostate carcinoma I: prognostic factors in radical prostatectomy specimens and pelvic lymph nodes
    Rodolfo Montironi
    Department of Pathology, Reina Sofia University Hospital and Cordoba University Medical School, Cordoba, Spain
    BJU Int 97:485-91. 2006
  57. ncbi request reprint Prostate carcinoma II: prognostic factors in prostate needle biopsies
    Rodolfo Montironi
    Department of Pathology, Reina Sofia University Hospital and Cordoba University Medical School, Cordoba, Spain
    BJU Int 97:492-7. 2006
  58. ncbi request reprint Target populations, pathological biomarkers and chemopreventive agents in prostate cancer prevention
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, University of Ancona, Ancona, Italy
    Arch Ital Urol Androl 75:127-34. 2003
    ..Histopathologists play an important role in prostate chemoprevention. In fact, they define the high-risk groups, recognise the surrogate end markers and evaluate the morphological effects of the agents on the prostate tissue specimens...
  59. ncbi request reprint Precancerous lesions and conditions of the prostate: from morphological and biological characterization to chemoprevention
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, University of Ancona, Ancona, Italy
    Ann N Y Acad Sci 963:169-84. 2002
    ..Prostatic carcinoma is also likely to arise from precursor lesions other than high-grade PIN such as low-grade PIN, atypical adenomatous hyperplasia, malignancy-associated foci, and atrophy...
  60. ncbi request reprint [Interstitial cystitis: minimal diagnostic criteria]
    Andrea Benedetto Galosi
    Gruppo Lavoro del Centro di Riferimento per le Malattie Rare, Clinica Urologica, Universita Politecnica delle Marche, Azienda Ospedaliero Universitaria Ospedali Riuniti, Ancona, Italy
    Urologia 77:160-71. 2010
    ..By using a stepwise approach and an evidence-based thought process, the diagnosis of IC is made easier and reliable...
  61. ncbi request reprint Molecular techniques and prostate cancer diagnostic
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, School of Medicine, Polytechnic University of the Marche Region Ancona, Azienda Ospedaliera Umberto I degrees, I 60020, Ancona, Torrette, Italy
    Eur Urol 44:390-400. 2003
    ..In this review several recently developed molecular techniques are described and illustrated. The focus is on prostate cancer diagnostics, as an example of their application...
  62. pmc Specimen orientation by marking the peripheral end: (potential) clinical advantages in prostate biopsy
    Andrea Benedetto Galosi
    Institute of Urology, Azienda Ospedaliero Universitaria, United Hospitals, Torrette, 60126 Ancona, Italy
    Prostate Cancer 2011:270403. 2011
    ..We can add a new pathological parameter: pathological orientation or biopsy polarity...
  63. ncbi request reprint Renal sarcoma associated with adult polycystic kidney disease. A case report and literature review
    Daniele Minardi
    Institute of Urology, Polytechnic University of the Marche Region, Ancona, Italy
    Arch Ital Urol Androl 76:94-6. 2004
    ....
  64. doi request reprint Cannabinoid CB1 receptor expression in relation to visceral adipose depots, endocannabinoid levels, microvascular damage, and the presence of the Cnr1 A3813G variant in humans
    Marica Bordicchia
    Department of Internal Medicine, University of Ancona Politecnica delle Marche, University Hospital of Ancona, Ancona, Italy
    Metabolism 59:734-41. 2010
    ..Increased VAT is associated with increased perirenal VAT endocannabinoid tone, which in turn correlates with increased MVDa. Endocannabinoid overactivity might be involved in human visceral obesity and its renal complications...
  65. pmc Elevation of c-FLIP in castrate-resistant prostate cancer antagonizes therapeutic response to androgen receptor-targeted therapy
    Clare McCourt
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, Northern Ireland
    Clin Cancer Res 18:3822-33. 2012
    ....
  66. ncbi request reprint Improving inter-observer agreement and certainty level in diagnosing and grading papillary urothelial neoplasms: usefulness of a Bayesian belief network
    Rodolfo Montironi
    Institute of Pathological Anatomy and Histopathology, University of Ancona, Umberto 1st Hospital, I 60020 Torrette, Ancona, Italy
    Eur Urol 41:449-57. 2002
    ..The aim of this study was to evaluate the contribution of a BBN in the improvement of inter-observer agreement and certainty level in the diagnosis and grading of papillary urothelial neoplasms...
  67. doi request reprint HtrA1 in human urothelial bladder cancer: a secreted protein and a potential novel biomarker
    Teresa Lorenzi
    Department of Experimental and Clinical Medicine, Universita Politecnica delle Marche, Via Tronto 10 A, Ancona, 60020, Italy
    Int J Cancer 133:2650-61. 2013
    ..65% and 95.59%, respectively). ..