L Mazzini

Summary

Country: Italy

Publications

  1. doi request reprint Transplantation of mesenchymal stem cells in ALS
    Letizia Mazzini
    ALS Centre, Department of Neurology, Eastern Piedmont University, Maggiore della Carita Hospital, Novara, Italy
    Prog Brain Res 201:333-59. 2012
  2. ncbi request reprint Stem cell treatment in Amyotrophic Lateral Sclerosis
    Letizia Mazzini
    Department of Neurology, Azienda Ospedaliera, Eastern Piedmont University of Novara, Novara, Italy
    J Neurol Sci 265:78-83. 2008
  3. ncbi request reprint Autologous mesenchymal stem cells: clinical applications in amyotrophic lateral sclerosis
    Letizia Mazzini
    Department of Neurology, Eastern Piedmont University of Novara, Novara, Italy
    Neurol Res 28:523-6. 2006
  4. doi request reprint Stem cells in amyotrophic lateral sclerosis: state of the art
    Letizia Mazzini
    Eastern Piedmont University, Maggiore della Carita Hospital, ALS Centre, Department of Neurology, Corso Mazzini 18, Novara 28100, Italy
    Expert Opin Biol Ther 9:1245-58. 2009
  5. doi request reprint Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I clinical trial
    L Mazzini
    Department of Neurology Eastern Piedmont University, Maggiore della Carita Hospital, 28100 Novara, Italy
    Exp Neurol 223:229-37. 2010
  6. ncbi request reprint Clinical applications of event-related potentials in brain injury
    Letizia Mazzini
    Department of Neurology, San Giovanni Bosco Hospital, Hospital Largo Donatori di Sangue 3, 10154 Torino, Italy
    Phys Med Rehabil Clin N Am 15:163-75. 2004
  7. ncbi request reprint Posttraumatic hydrocephalus: a clinical, neuroradiologic, and neuropsychologic assessment of long-term outcome
    Letizia Mazzini
    Department of Neurology, San Giovanni Bosco Hospital, Turin, Italy
    Arch Phys Med Rehabil 84:1637-41. 2003
  8. ncbi request reprint Stem cell therapy in amyotrophic lateral sclerosis: a methodological approach in humans
    Letizia Mazzini
    Department of Neurology, University of Torino, Italy
    Amyotroph Lateral Scler Other Motor Neuron Disord 4:158-61. 2003
  9. ncbi request reprint Effects of creatine supplementation on exercise performance and muscular strength in amyotrophic lateral sclerosis: preliminary results
    L Mazzini
    Department of Neurology, San Giovanni Bosco Hospital, Largo Donatore di sangue 3, 10154, Torino, Italy
    J Neurol Sci 191:139-44. 2001
  10. doi request reprint Mesenchymal stromal cell transplantation in amyotrophic lateral sclerosis: a long-term safety study
    Letizia Mazzini
    ALS Centre Department of Neurology Eastern Piedmont University, Maggiore della Carita Hospital, Novara, Italy
    Cytotherapy 14:56-60. 2012

Detail Information

Publications26

  1. doi request reprint Transplantation of mesenchymal stem cells in ALS
    Letizia Mazzini
    ALS Centre, Department of Neurology, Eastern Piedmont University, Maggiore della Carita Hospital, Novara, Italy
    Prog Brain Res 201:333-59. 2012
    ..In this review, the authors discuss the major challenges to the translation of in vitro and animal studies of MSCs therapy in the clinical setting...
  2. ncbi request reprint Stem cell treatment in Amyotrophic Lateral Sclerosis
    Letizia Mazzini
    Department of Neurology, Azienda Ospedaliera, Eastern Piedmont University of Novara, Novara, Italy
    J Neurol Sci 265:78-83. 2008
    ..A new phase 1 study is carried out to verify these data in a larger number of patients...
  3. ncbi request reprint Autologous mesenchymal stem cells: clinical applications in amyotrophic lateral sclerosis
    Letizia Mazzini
    Department of Neurology, Eastern Piedmont University of Novara, Novara, Italy
    Neurol Res 28:523-6. 2006
    ..Our study was aimed to evaluate the feasibility and safety of intraspinal cord implantation of autologous mesenchymal stem cells (MSCs) in a few well-monitored amyotrophic lateral sclerosis (ALS) patients...
  4. doi request reprint Stem cells in amyotrophic lateral sclerosis: state of the art
    Letizia Mazzini
    Eastern Piedmont University, Maggiore della Carita Hospital, ALS Centre, Department of Neurology, Corso Mazzini 18, Novara 28100, Italy
    Expert Opin Biol Ther 9:1245-58. 2009
    ..Here we summarise and discuss current preclinical and clinical evidence regarding stem cells application in ALS, particularly focusing on methodological issues...
  5. doi request reprint Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I clinical trial
    L Mazzini
    Department of Neurology Eastern Piedmont University, Maggiore della Carita Hospital, 28100 Novara, Italy
    Exp Neurol 223:229-37. 2010
    ..In conclusion, this study confirms that MSC transplantation into the spinal cord of ALS patients is safe and that MSCs might have a clinical use for future ALS cell based clinical trials...
  6. ncbi request reprint Clinical applications of event-related potentials in brain injury
    Letizia Mazzini
    Department of Neurology, San Giovanni Bosco Hospital, Hospital Largo Donatori di Sangue 3, 10154 Torino, Italy
    Phys Med Rehabil Clin N Am 15:163-75. 2004
    ..Nevertheless, ERPs might be applied as a useful supplement to neuropsychologic assessment...
  7. ncbi request reprint Posttraumatic hydrocephalus: a clinical, neuroradiologic, and neuropsychologic assessment of long-term outcome
    Letizia Mazzini
    Department of Neurology, San Giovanni Bosco Hospital, Turin, Italy
    Arch Phys Med Rehabil 84:1637-41. 2003
    ..To detect the clinical and radiologic characteristics of posttraumatic hydrocephalus (PTH), to define its prognostic value, and to assess the effects of shunt surgery...
  8. ncbi request reprint Stem cell therapy in amyotrophic lateral sclerosis: a methodological approach in humans
    Letizia Mazzini
    Department of Neurology, University of Torino, Italy
    Amyotroph Lateral Scler Other Motor Neuron Disord 4:158-61. 2003
    ..We have evaluated the feasibility and safety of a method of intraspinal cord implantation of autologous mesenchymal stem cells (MSCs) in a few well-monitored patients with ALS...
  9. ncbi request reprint Effects of creatine supplementation on exercise performance and muscular strength in amyotrophic lateral sclerosis: preliminary results
    L Mazzini
    Department of Neurology, San Giovanni Bosco Hospital, Largo Donatore di sangue 3, 10154, Torino, Italy
    J Neurol Sci 191:139-44. 2001
    ....
  10. doi request reprint Mesenchymal stromal cell transplantation in amyotrophic lateral sclerosis: a long-term safety study
    Letizia Mazzini
    ALS Centre Department of Neurology Eastern Piedmont University, Maggiore della Carita Hospital, Novara, Italy
    Cytotherapy 14:56-60. 2012
    ..We present the results of long-term monitoring of 19 ALS patients enrolled in two phase I clinical trials of autologous MSC transplantation...
  11. doi request reprint Tracheostomy in amyotrophic lateral sclerosis: a 10-year population-based study in Italy
    A Chio
    ALS Centre, Department of Neuroscience, University of Torino, Torino, Italy
    J Neurol Neurosurg Psychiatry 81:1141-3. 2010
    ..In conclusion, in an epidemiological setting, ALS survival after tracheostomy was <1 year. Sociocultural factors influence the probability of choice to be tracheostomised, even in a highly socialized health system as Italian one...
  12. doi request reprint Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis
    A Vercelli
    Department of Anatomy, Pharmacology and Forensic Medicine, National Institute of Neuroscience, Turin, Italy
    Neurobiol Dis 31:395-405. 2008
    ....
  13. doi request reprint Epidemiology of ALS in Italy: a 10-year prospective population-based study
    A Chio
    Department of Neuroscience, University of Torino, Italy
    Neurology 72:725-31. 2009
    ..To describe the temporal patterns of incidence and demographic characteristics of amyotrophic lateral sclerosis (ALS) in Piemonte and Valle d'Aosta, Italy, in the 10-year period 1995 through 2004...
  14. ncbi request reprint SOD1 gene mutations in Italian patients with Sporadic Amyotrophic Lateral Sclerosis (ALS)
    L Corrado
    Department of Medical Sciences, University of Eastern Piedmont, Novara, Italy
    Neuromuscul Disord 16:800-4. 2006
    ..No association was found with intronic sequence variations by comparing their frequency in the patients and in 181 matched controls...
  15. doi request reprint High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis
    Lucia Corrado
    Department of Medical Sciences, Interdisciplinary Research Center of Autoimmune Diseases IRCAD, University of Eastern Piedmont, Novara, Italy
    Hum Mutat 30:688-94. 2009
    ..In conclusion, this report contributes to the demonstration of the causative role of the TARDBP gene in ALS pathogenesis and indicates that mutations may affect the stability of the protein even in nonneuronal tissues...
  16. ncbi request reprint Posttraumatic epilepsy: neuroradiologic and neuropsychological assessment of long-term outcome
    Letizia Mazzini
    Department of Neurology, San Giovanni Bosco Hospital, Torino, Italy
    Epilepsia 44:569-74. 2003
    ....
  17. ncbi request reprint Bone marrow mesenchymal stem cells from healthy donors and sporadic amyotrophic lateral sclerosis patients
    Ivana Ferrero
    Department of Pediatrics, Regina Margherita Children s Hospital, University of Turin, Turin, Italy
    Cell Transplant 17:255-66. 2008
    ..Hence, there is a good chance that MSCs might be used as a cell-based therapy for ALS patients...
  18. ncbi request reprint Motor neuron disease: usefulness of transcranial magnetic stimulation in improving the diagnosis
    G Miscio
    Department of Neurology, Salvatore Maugeri Foundation, IRCCS, Rehabilitation Institute, Veruno NO, Italy
    Clin Neurophysiol 110:975-81. 1999
    ..In conclusion, TMS provides important diagnostic information for an early prediction of ALS in those MND patients presenting with clinically equivocal UMN impairment...
  19. ncbi request reprint The structured assessment of depression in brain-damaged individuals: translation and validation study of the Italian version
    F Monaco
    Department of Neurology, Amedeo Avogadro University, Novara, Italy
    Neurol Sci 26:182-4. 2005
    ..51; correlation between caregiver and physician diagnosis was 0.60. The Italian version of the SADBD was demonstrated to be acceptable, reliable and a valid measure of depression in patients with stroke...
  20. ncbi request reprint Early symptom progression rate is related to ALS outcome: a prospective population-based study
    A Chio
    Division of Neurology, Department of Neuroscience, University of Torino and Azienda Ospedaliera S Giovanni Battista, Torino, Italy
    Neurology 59:99-103. 2002
    ..To define the factors related to ALS outcome in a population-based, prospective survey...
  21. ncbi request reprint Variations in the coding and regulatory sequences of the angiogenin (ANG) gene are not associated to ALS (amyotrophic lateral sclerosis) in the Italian population
    Lucia Corrado
    Laboratory of Human Genetics, Department of Medical Sciences and IRCAD Interdisciplinary Research Center of Autoimmune Diseases, Eastern Piedmont University, Novara, Italy
    J Neurol Sci 258:123-7. 2007
    ..In conclusion, we did not detect the association with rs11701-G or with any other newly detected variation in the ANG regulatory region. Furthermore we did not identify potentially causal mutations in the coding region...
  22. doi request reprint Mutations of FUS gene in sporadic amyotrophic lateral sclerosis
    Lucia Corrado
    Department of Medical Sciences, Via Solaroli, 17, 28100 Novara, Italy
    J Med Genet 47:190-4. 2010
    ..Mutations in the FUS gene have recently been discovered to be a major cause of familial amyotrophic lateral sclerosis (FALS)...
  23. ncbi request reprint Stem-cell therapy in amyotrophic lateral sclerosis
    Letizia Mazzini
    Lancet 364:1936-7. 2004
  24. ncbi request reprint Report from the Italian Ministerial Committee regarding the diagnosis, care and assistance of patients with ALS
    Caterina Bendotti
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:5-7. 2005
  25. ncbi request reprint Reliability of the El Escorial diagnostic criteria for amyotrophic lateral sclerosis
    Ettore Beghi
    Clinica Neurologica, Ospedale San Gerardo, Monza, Italia
    Neuroepidemiology 21:265-70. 2002
    ..The accuracy of the El Escorial criteria was tested in clinical practice, but the reliability is unknown when the diagnosis of ALS must be assessed on the basis of medical records...
  26. ncbi request reprint The cortico-diaphragmatic pathway involvement in amyotrophic lateral sclerosis: neurophysiological, respiratory and clinical considerations
    Giacinta Miscio
    Department of Neurology and Neurorehabilitation, Istituto Auxologico Italiano, IRCCS, Piancavallo VB, Italy
    J Neurol Sci 251:10-6. 2006
    ..In conclusion, cortico-diaphragmatic study is a sensitive measure to reveal subclinical diaphragmatic impairment although not correlated to respiratory measures...