Research Topics
| G MartinottiSummaryCountry: Italy Publications
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Publications
Acetyl-l-Carnitine in the treatment of anhedonia, melancholic and negative symptoms in alcohol dependent subjectsGiovanni Martinotti
Institute of Psychiatry, Catholic University Medical School, Rome, Italy
Prog Neuropsychopharmacol Biol Psychiatry 35:953-8. 2011..Secondary endpoints were the effect of ALC on melancholic and negative symptoms...
Alcohol protracted withdrawal syndrome: the role of anhedoniaG Martinotti
Department of Psychiatry Addictive Behaviours, Catholic University Medical School, Rome, Italy
Subst Use Misuse 43:271-84. 2008..The aim of the present study is to characterize the relevance of withdrawal symptoms during the first 12 months of abstinence and their relation to anhedonia and craving...
Quetiapine decreases alcohol consumption, craving, and psychiatric symptoms in dually diagnosed alcoholicsG Martinotti
Department of Psychiatry Addictive Behaviours Unit, Catholic University Medical School, Rome, Italy
Hum Psychopharmacol 23:417-24. 2008..The purpose of this study was to investigate the safety and efficacy of quetiapine in the treatment of alcohol dependence comorbid with disorders characterized by high levels of mood and behavioral instability...
Aripiprazole in the treatment of patients with alcohol dependence: a double-blind, comparison trial vs. naltrexoneG Martinotti
Department of Psychiatry, Catholic University Medical School, Rome, Italy
J Psychopharmacol 23:123-9. 2009....
Efficacy and safety of pregabalin in alcohol dependenceGiovanni Martinotti
Department of Psychiatry, Catholic University Medical School, Rome, Italy
Adv Ther 25:608-18. 2008..Reduction of cravings, psychiatric symptom improvements, and the evaluation of safety parameters were the secondary endpoints...
Empathy ability is impaired in alcohol-dependent patientsGiovanni Martinotti
Department of Psychiatry, Catholic University Medical School, Rome, Italy
Am J Addict 18:157-61. 2009..Further, the lack of empathy could lead latent abusers to find in the alcohol misuse something enabling them to compensate for their intrinsic weakness...
Pregabalin versus naltrexone in alcohol dependence: a randomised, double-blind, comparison trialG Martinotti
Department of Psychiatry, Catholic University Medical School, Rome, Italy
J Psychopharmacol 24:1367-74. 2010..The mechanism involved in the efficacy of PRE in relapse prevention could be less related to alcohol craving and more associated with the treatment of the comorbid psychiatric symptomatology...
Mono- and polysubstance dependent subjects differ on social factors, childhood trauma, personality, suicidal behaviour, and comorbid Axis I diagnosesG Martinotti
Institute of Psychiatry, Catholic University Medical School, Rome, Italy
Addict Behav 34:790-3. 2009..The study aimed to examine the clinical correlates of polysubstance dependence...
Pregabalin, tiapride and lorazepam in alcohol withdrawal syndrome: a multi-centre, randomized, single-blind comparison trialGiovanni Martinotti
Clinica Villa Maria Pia, Via del Forte Trionfale 36, Rome 00135 Italy
Addiction 105:288-99. 2010..These drugs were chosen for their inhibitorial effects on the hypersecretion of neurotransmitters usually observed in AWS. Craving reduction and improvement of psychiatric symptoms were the secondary end-points...
Acetyl-L-carnitine for alcohol craving and relapse prevention in anhedonic alcoholics: a randomized, double-blind, placebo-controlled pilot trialGiovanni Martinotti
Clinica Villa Maria Pia, Rome, Italy
Alcohol Alcohol 45:449-55. 2010..The study aimed to evaluate the efficacy of acetyl-l-carnitine (ALC), at different doses, in relapse prevention and craving in anhedonic detoxified alcohol-dependent subjects...
Prevalence and intensity of basic symptoms among cannabis users: an observational studyGiovanni Martinotti
Institute of Psychiatry, Catholic University Medical School, Rome, Italy
Am J Drug Alcohol Abuse 37:111-6. 2011..It is difficult to establish whether people who are prone to psychosis are drawn to cannabis use or whether cannabis use truly increases the incidence of psychotic experiences...
Temperament and character inventory dimensions and anhedonia in detoxified substance-dependent subjectsG Martinotti
Department of Psychiatry, Drug Addiction Unit, Catholic University Medical School, Rome, Italy
Am J Drug Alcohol Abuse 34:177-83. 2008....
The dimensional assessment of personality in pathologic and social gamblers: the role of novelty seeking and self-transcendenceGiovanni Martinotti
Department of Psychiatry, Catholic University Medical School, 00167 Rome, Italy
Compr Psychiatry 47:350-6. 2006..A few personality traits are characteristic of pathologic gamblers (PGs), but it is not clear if and how their personality profile differs from that of non-pathologic gamblers (non-PGs)...
High and low dosage oxcarbazepine versus naltrexone for the prevention of relapse in alcohol-dependent patientsG Martinotti
Department of Psychiatry, Catholic University Medical School, Rome, Italy
Hum Psychopharmacol 22:149-56. 2007..Craving and psychiatric symptoms improvements were the secondary endpoints...
Efficacy and safety of aripiprazole in alcohol dependenceGiovanni Martinotti
Department of Psychiatry, Catholic University Medical School, Rome, Italy
Am J Drug Alcohol Abuse 33:393-401. 2007..05) and VAS (p < .05), and a decrease of the SCL-90 General Severity Index (GSI) (p < .05). The data of this pilot clinical study, suggest a possible role for this drug in the treatment of individuals with alcohol problems...
Anhedonia and substance-related symptoms in detoxified substance-dependent subjects: a correlation studyL Janiri
Institute of Psychiatry and Psychology, Treatment Unit for Alcoholism and Multiple Drug Abuse, Catholic University, Rome, Italy
Neuropsychobiology 52:37-44. 2005..In conclusion, we found interrelations between hedonic capability, craving and protracted withdrawal, particularly in opiate-dependent subjects. The strongest association occurred between hedonic capability and craving...
Pregabalin in outpatient detoxification of subjects with mild-to-moderate alcohol withdrawal syndromeM Di Nicola
Institute of Psychiatry, Catholic University Medical School, Rome, Italy
Hum Psychopharmacol 25:268-75. 2010..Craving reduction, improvement of psychiatric symptoms and quality of life were the secondary endpoints...
The Gamblers' Temperament and Character Inventory (TCI) personality profileL Janiri
Department of Psychiatry, Catholic University Medical School, Rome, Italy
Subst Use Misuse 42:975-84. 2007..001) CO values. Specific temperamental (NS) and character (SD; CO) dimensions differentiated PPGs from both non-PGs and controls; assessment of personality profile with the TCI may identify at-risk social gamblers...
Cocaine use disorders and serum magnesium profileF Tonioni
Department of Psychiatry, Catholic University Medical School, Rome, Italy
Neuropsychobiology 59:159-64. 2009..We also attempted to clarify the relationship between the pathophysiology of cocaine abuse and magnesium levels by investigating their association with various clinical dimensions...
Clinical features, response to treatment and functional outcome of bipolar disorder patients with and without co-occurring substance use disorder: 1-year follow-upMarianna Mazza
Department of Psychiatry, Bipolar Disorders Unit, Catholic University of Sacred Heart, Rome, Italy
J Affect Disord 115:27-35. 2009..The purpose of this study was to examine clinical and psychopathological features of BP with and without comorbid SUD in a real-world setting...
Behavioural addictions in bipolar disorder patients: role of impulsivity and personality dimensionsMarco Di Nicola
Institute of Psychiatry, Bipolar Disorder Unit, Catholic University Medical School, Rome, Italy
J Affect Disord 125:82-8. 2010....
The assessment of post-detoxification anhedonia: influence of clinical and psychosocial variablesGino Pozzi
Day Hospital of Clinical Psychiatry and Substance Dependence, Institute of Psychiatry and Psychology, Catholic University of the Sacred Heart, Rome, Italy
Subst Use Misuse 43:722-32. 2008..Even if the study's limitations are noted, anhedonia appears as a psychopathological entity independent from other clinical and psychosocial features of treated addicts...
Psychometric characteristic of the Italian version of the Temperament and Character Inventory--revised, personality, psychopathology, and attachment stylesGiovanni Martinotti
Department of Psychiatry, Catholic University Medical School, 00168 Rome, Italy
Compr Psychiatry 49:514-22. 2008..Personality features are also confirmed as risk factors for specific psychopathologic domains, impulsivity, anger, and hostility. Furthermore, we found attachment styles of nonclinical subjects correlated with personality features...
Oxcarbazepine in bipolar disorder: a critical review of the literatureMarianna Mazza
Institute of Psychiatry, Bipolar Disorders Unit, Catholic University of Sacred Heart, Rome, Italy
Expert Opin Pharmacother 8:649-56. 2007..OXC can be particularly useful as an add-on treatment in bipolar disorder patients for whom previous treatments have failed, or in patients who have difficulty tolerating adequate dosages of standard approved treatments...
Acetyl-L-carnitine in the management of pain during methadone withdrawal syndromeLuigi Janiri
Department of Psychiatry, Catholic University Medical School, Rome, Italy
Clin Neuropharmacol 32:35-40. 2009..The study consists of 2 branches: a clinical study and a preclinical one, both with a randomized placebo-controlled design...
Harm avoidance moderates the influence of serotonin transporter gene variants on treatment outcome in bipolar patientsLaura Mandelli
Department of Psychiatry, University of Bologna, Italy
J Affect Disord 119:205-9. 2009..Given that many factors may influence response to pharmacological treatments, studies that consider personality and other individual characteristics are warranted also in pharmacogenetic investigations...
Reduced fronto-temporal connectivity is associated with frontal gray matter density reduction and neuropsychological deficit in schizophreniaIlaria Spoletini
IRCCS Santa Lucia Foundation, Rome, Italy
Schizophr Res 108:57-68. 2009..The second objective was to identify the neuropsychological correlates of white matter abnormalities in the schizophrenic group, using a comprehensive neuropsychological battery...
Prefrontal-thalamic-cerebellar gray matter networks and executive functioning in schizophreniaNICOLAS RUSCH
IRCCS Fondazione Santa Lucia, Rome, Italy
Schizophr Res 93:79-89. 2007....
Oxcarbazepine improves mood in patients with epilepsyMarianna Mazza
Institute of Psychiatry and Psychology, Catholic University of Sacred Heart, Via Ugo De Carolis 48, 00136 Rome, Italy
Epilepsy Behav 10:397-401. 2007....
Aripiprazole for relapse prevention and craving in alcohol-dependent subjects: results from a pilot studyLuigi Janiri
J Clin Psychopharmacol 27:519-20. 2007
Oxcarbazepine at high dosages for the treatment of alcohol dependenceGiovanni Martinotti
Am J Addict 16:247-8. 2007
New trends in the cyber and street market of recreational drugs? The case of 2C-T-7 ('Blue Mystic')Fabrizio Schifano
Division of Mental Health Addictive Behaviour, St George s Hospital Medical School, University of London, London, UK
J Psychopharmacol 19:675-9. 2005..Projects aimed at designing more 'attractive' prevention websites should be planned and future studies should better assess the characteristics of those consumers who take advantage of the online information of hallucinogenic compounds...
Importance of cyberspace for the assessment of the drug abuse market: preliminary results from the Psychonaut 2002 projectFabrizio Schifano
Addictive Behaviour Section, Department of Mental Health, St George s Hospital Medical School, University of London, London, UK
Cyberpsychol Behav 6:405-10. 2003..Preliminary results of a search on MDMA and MDMA-like substances confirm that it is possible both to identify emerging trends and to provide information for prevention and appropriate intervention...
