Davide Martino

Summary

Country: Italy

Publications

  1. ncbi request reprint Soluble adhesion molecules in Gilles de la Tourette's syndrome
    D Martino
    Neuroimmunology Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    J Neurol Sci 234:79-85. 2005
  2. pmc Tracing Sydenham's chorea: historical documents from a British paediatric hospital
    D Martino
    Department of Neuroinflammation, Institute of Neurology, University College Medical School, London, UK
    Arch Dis Child 90:507-11. 2005
  3. doi request reprint Anti-basal ganglia antibodies and Tourette's syndrome: a voxel-based morphometry and diffusion tensor imaging study in an adult population
    D Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    J Neurol Neurosurg Psychiatry 79:820-2. 2008
  4. doi request reprint The relationship between group A streptococcal infections and Tourette syndrome: a study on a large service-based cohort
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Dev Med Child Neurol 53:951-7. 2011
  5. doi request reprint Immunopathogenic mechanisms in tourette syndrome: A critical review
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Mov Disord 24:1267-79. 2009
  6. ncbi request reprint The natural history of Unverricht-Lundborg disease: a report of eight genetically proven cases
    Nee K Chew
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 23:107-13. 2008
  7. doi request reprint Eye symptoms in relatives of patients with primary adult-onset dystonia
    Giovanni Defazio
    Department of Neurosciences and Sensory Organs, School of Motor Sciences, Aldo Moro University of Bari, Bari, Italy
    Mov Disord 27:305-7. 2012
  8. doi request reprint Age at onset and symptom spread in primary adult-onset blepharospasm and cervical dystonia
    Davide Martino
    Department of Neurosciences and Sensory Organs and School of Motor Sciences, Aldo Moro University of Bari, Bari, Italy
    Mov Disord 27:1447-50. 2012
  9. doi request reprint Antineuronal antibodies in Parkinson's disease
    Bart P C van de Warrenburg
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 23:958-63. 2008
  10. pmc Head trauma in primary cranial dystonias: a multicentre case-control study
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare, 11 70124 Bari, Italy
    J Neurol Neurosurg Psychiatry 78:260-3. 2007

Detail Information

Publications48

  1. ncbi request reprint Soluble adhesion molecules in Gilles de la Tourette's syndrome
    D Martino
    Neuroimmunology Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    J Neurol Sci 234:79-85. 2005
    ..These results provide initial evidence for a role of adhesion molecules and systemic inflammation in TS, and support the hypothesis of an ongoing immune-mediated process in this condition...
  2. pmc Tracing Sydenham's chorea: historical documents from a British paediatric hospital
    D Martino
    Department of Neuroinflammation, Institute of Neurology, University College Medical School, London, UK
    Arch Dis Child 90:507-11. 2005
    ....
  3. doi request reprint Anti-basal ganglia antibodies and Tourette's syndrome: a voxel-based morphometry and diffusion tensor imaging study in an adult population
    D Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    J Neurol Neurosurg Psychiatry 79:820-2. 2008
    ..These results suggest that ABGA synthesis is not related to structural changes in grey and white matter (detectable with these methods) within frontostriatal circuits...
  4. doi request reprint The relationship between group A streptococcal infections and Tourette syndrome: a study on a large service-based cohort
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Dev Med Child Neurol 53:951-7. 2011
    ..To evaluate the relationship between diagnosis and clinical course of Tourette syndrome and group A Streptococcus (GAS)...
  5. doi request reprint Immunopathogenic mechanisms in tourette syndrome: A critical review
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Mov Disord 24:1267-79. 2009
    ..Although the pathogenic role of immune activation in TS has not been definitively proven, a pathophysiological model is proposed to explain the possible effect of immunity upon dopamine transmission regulation and the generation of tics...
  6. ncbi request reprint The natural history of Unverricht-Lundborg disease: a report of eight genetically proven cases
    Nee K Chew
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 23:107-13. 2008
    ..The clinical phenotypes associated with ULD are more diverse than previously recognized and even though the long term functional outcome and survival have improved, the overall efficacy of antimyoclonic drugs remains unsatisfactory...
  7. doi request reprint Eye symptoms in relatives of patients with primary adult-onset dystonia
    Giovanni Defazio
    Department of Neurosciences and Sensory Organs, School of Motor Sciences, Aldo Moro University of Bari, Bari, Italy
    Mov Disord 27:305-7. 2012
    ....
  8. doi request reprint Age at onset and symptom spread in primary adult-onset blepharospasm and cervical dystonia
    Davide Martino
    Department of Neurosciences and Sensory Organs and School of Motor Sciences, Aldo Moro University of Bari, Bari, Italy
    Mov Disord 27:1447-50. 2012
    ..This study explored the relationship between age and spread of dystonia in primary adult-onset focal dystonia...
  9. doi request reprint Antineuronal antibodies in Parkinson's disease
    Bart P C van de Warrenburg
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 23:958-63. 2008
    ..We conclude that ANAs do not play a role in the majority of patients with IPD, but might be relevant in the pathogenesis of IPD with atypical features...
  10. pmc Head trauma in primary cranial dystonias: a multicentre case-control study
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare, 11 70124 Bari, Italy
    J Neurol Neurosurg Psychiatry 78:260-3. 2007
    ..The relationship between prior trauma and primary adult-onset dystonia is not well understood. Previous uncontrolled observations and exploratory case-control studies have yielded contradictory results...
  11. ncbi request reprint Autoaggressive immune-mediated movement disorders
    Davide Martino
    Institute of Neurology, Department of Neuroimmunology, University College London, London, United Kingdom
    Adv Neurol 96:320-35. 2005
    ....
  12. ncbi request reprint Antineuronal antibody status and phenotype analysis in Tourette's syndrome
    Davide Martino
    Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 22:1424-9. 2007
    ..14; P = 0.002; 95% confidence interval 0.04-0.49). ANeA status does not differentiate a specific phenotype of GTS...
  13. doi request reprint The phenomenology of the geste antagoniste in primary blepharospasm and cervical dystonia
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Mov Disord 25:407-12. 2010
    ..01). GA features shared by BSP and CD predominate over differences, suggesting common mechanisms underlying this phenomenon in the two forms of primary adult-onset dystonia...
  14. ncbi request reprint Planning genetic studies on primary adult-onset dystonia: sample size estimates based on examination of first-degree relatives
    Giovanni Defazio
    Department of Neurologic and Psychiatric Sciences, University of Bari, Bari, Italy
    J Neurol Sci 251:29-34. 2006
    ..These sample size estimates suggest that the S-TDT may be feasible, whereas collection of cases for both TDT and ASP approaches would represent a major collaborative challenge...
  15. pmc The differential diagnosis of Huntington's disease-like syndromes: 'red flags' for the clinician
    Davide Martino
    Neuroscience and Trauma Centre, Barts and the London School of Medicine and Dentistry, Queen Mary University London, London, UK
    J Neurol Neurosurg Psychiatry 84:650-6. 2013
    ..These red flags should be constantly updated as the phenotypic characterisation and identification of more reliable diagnostic markers for HD-like syndromes progress over the following years...
  16. doi request reprint Pain as a nonmotor symptom of Parkinson disease: evidence from a case-control study
    Giovanni Defazio
    Department of Neurology and Psychiatry, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    Arch Neurol 65:1191-4. 2008
    ..To determine whether pain is more frequent among people with Parkinson disease (PD) than among age-matched controls...
  17. doi request reprint Cortical gray matter changes in primary blepharospasm: a voxel-based morphometry study
    Davide Martino
    Neurological Section, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mov Disord 26:1907-12. 2011
    ..Gray matter changes in the primary sensory cortex may represent a common trait of primary dystonias, including blepharospasm...
  18. ncbi request reprint Soluble adhesion molecules in acute disseminated encephalomyelitis
    Davide Martino
    Department of Neuroinflammation, Institute of Neurology, University College London, UK
    Pediatr Neurol 33:255-8. 2005
    ..Further larger studies are required including serial measurements and cerebrospinal fluid analysis...
  19. doi request reprint Cortical excitability is abnormal in patients with the "fixed dystonia" syndrome
    Laura Avanzino
    Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 23:646-52. 2008
    ..SAI and LAI did not significantly differ between the three groups. The abnormal cortical excitability observed in FD might represent an underlying trait predisposing to different clinical forms of dystonia...
  20. doi request reprint The TOR1A polymorphism rs1182 and the risk of spread in primary blepharospasm
    Giovanni Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Policlinico, Piazza Giulio Cesare, Bari 1 70124, Italy
    Mov Disord 24:613-6. 2009
    ..The comparable findings obtained in two independent cohorts support a genetic contribution to BSP spread...
  21. ncbi request reprint Are nongenetic triggers for dystonia type-specific? A study exploring scoliosis in blepharospasm
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mov Disord 22:576-8. 2007
    ..The frequency of scoliosis did not differ between blepharospasm patients and controls. This finding supports the hypothesis that environmental risk factors may be specific for a single form of adult-onset dystonia...
  22. ncbi request reprint Antibasal ganglia antibodies and their relevance to movement disorders
    Davide Martino
    Institute of Neurology, University College London, UK
    Curr Opin Neurol 17:425-32. 2004
    ..This review summarizes the most recent studies concerning antibasal ganglia antibodies, focusing on the associated phenotypes and the hypotheses concerning their pathogenicity...
  23. doi request reprint Prevalence and phenomenology of eye tics in Gilles de la Tourette syndrome
    Davide Martino
    Neuroscience and Trauma Centre, Barts and The London School Medicine and Dentistry, Queen Mary University of London, London, UK
    J Neurol 259:2137-40. 2012
    ..Eye tic phenomenology was similar in patients with or without co-morbidity. Eye tics are therefore likely to be a core feature of GTS and should be routinely evaluated in order to strengthen the clinician's confidence in diagnosing GTS...
  24. ncbi request reprint Are antibasal ganglia antibodies important, and clinically useful?
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Pract Neurol 7:32-41. 2007
  25. doi request reprint The PANDAS subgroup of tic disorders and childhood-onset obsessive-compulsive disorder
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    J Psychosom Res 67:547-57. 2009
    ..Given the relevance of this topic for general pediatric health, additional research efforts to solve all the pending issues and the hottest points of debate are warranted...
  26. doi request reprint Speech-induced blepharospasm
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, 70124, Bari, Italy
    Neurol Sci 31:71-3. 2010
    ....
  27. ncbi request reprint Hyperhomocysteinemia in movement disorders: Current evidence and hypotheses
    Stefano Zoccolella
    Department of Neurological Sciences, University of Bari, Italy
    Curr Vasc Pharmacol 4:237-43. 2006
    ....
  28. ncbi request reprint Sensitivity and specificity of a self-administered questionnaire for familial screening of adult-onset dystonia
    Maria Stella Aniello
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Mov Disord 21:571-5. 2006
    ..This questionnaire may be an important screening resource for familial aggregation studies to be used in the context of a complex case-finding procedure...
  29. ncbi request reprint Relationship between eye symptoms and blepharospasm: a multicenter case-control study
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mov Disord 20:1564-70. 2005
    ..The differential risk of developing BSP, based on age at onset of ocular symptoms, suggests that age and eye diseases may interact in giving rise to BSP...
  30. ncbi request reprint The entity of young onset primary cervical dystonia
    Vasiliki Koukouni
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 22:843-7. 2007
    ..74% responded favorably to botulinum toxin injections, whereas none of the 13 patients treated with L-Dopa preparations had a beneficial response. The distinctive features of this entity are discussed...
  31. ncbi request reprint Atypical movement disorders in antiphospholipid syndrome
    Davide Martino
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Mov Disord 21:944-9. 2006
    ..Movement disorders in APS seem more clinically heterogeneous than previously thought. Oral anticoagulation should be considered in the treatment of movement disorders associated with APS...
  32. ncbi request reprint Bilateral striatal necrosis, dystonia and multiple mitochondrial DNA deletions: case study and effect of deep brain stimulation
    Maria Stella Aniello
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mov Disord 23:114-8. 2008
    ..Globus pallidus interna deep brain stimulation produced sustained benefit, with predominant improvements in disability...
  33. doi request reprint Immune dysfunction in Tourette syndrome
    Ishraga Elamin
    Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, London, UK
    Behav Neurol 27:23-32. 2013
    ..Finally, TS patients could be prone to allergic illnesses (asthma, atopic dermatitis, rhinitis, conjunctivitis), but more work is needed in this area...
  34. doi request reprint Neuroendocrine aspects of Tourette syndrome
    Davide Martino
    Queen Elizabeth Hospital, Woolwich, London, United Kingdom Centre for Neuroscience and Trauma, Queen Mary University of London, London, United Kingdom King s College Hospital, London, United Kingdom Electronic address
    Int Rev Neurobiol 112:239-79. 2013
    ..In contrast, there is anecdotal clinical evidence that tics improve following periods of affectionate touch and sexual intercourse. ..
  35. ncbi request reprint Validity of family history data on primary adult-onset dystonia
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, 1 70124 Bari, Italy
    Arch Neurol 61:1569-73. 2004
    ..To our knowledge, no study has assessed the validity of family history data provided by probands with adult-onset dystonia...
  36. doi request reprint Neurofilament ELISA validation
    Axel Petzold
    Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    J Immunol Methods 352:23-31. 2010
    ..As these markers become more widely used, an inter-laboratory validation study is required to identify assay criteria for high quality performance...
  37. doi request reprint An introduction to the clinical phenomenology of Tourette syndrome
    Davide Martino
    Queen Elizabeth Hospital, Woolwich, London, United Kingdom Centre for Neuroscience and Trauma, Queen Mary University of London, London, United Kingdom King s College Hospital, London, United Kingdom Electronic address
    Int Rev Neurobiol 112:1-33. 2013
    ....
  38. ncbi request reprint Anti-basal ganglia antibodies in patients with atypical dystonia and tics: a prospective study
    M J Edwards
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London, UK
    Neurology 63:156-8. 2004
    ..An autoimmune mechanism may underlie a proportion of cases of atypical movement disorders...
  39. pmc Influence of age on the association between primary hemifacial spasm and arterial hypertension
    G Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    J Neurol Neurosurg Psychiatry 74:979-81. 2003
    ..To investigate the association between primary hemifacial spasm and arterial hypertension...
  40. ncbi request reprint Interferon beta-1a counteracts effects of activation on the expression of G-protein-coupled receptor kinases 2 and 3, beta-arrestin-1, and regulators of G-protein signalling 2 and 16 in human mononuclear leukocytes
    Maurizio Giorelli
    Department of Neurologic and Psychiatric Sciences, University of Bari, I 70124 Bari, Italy
    Cell Signal 14:673-8. 2002
    ..Furthermore, IFN beta-1a quenches the effects of PHA on the isoproterenol-induced accumulation of cyclic AMP (cAMP). We suggest that regulation of GPCRs responsiveness may be a relevant property of IFN beta-1a in MS...
  41. ncbi request reprint Interferon beta-1a downregulates TNFalpha-induced intercellular adhesion molecule 1 expression on brain microvascular endothelial cells through a tyrosine kinase-dependent pathway
    G Defazio
    Department of Neurologic and Psychiatric Sciences, University of Bari, I 70124, Bari, Italy
    Brain Res 881:227-30. 2000
    ..These findings indicate that a TK- rather than a PKC-dependent mechanism is involved in the modulation of TNFalpha response by IFbeta-1a on BMECs...
  42. pmc Influence of coffee drinking and cigarette smoking on the risk of primary late onset blepharospasm: evidence from a multicentre case control study
    G Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    J Neurol Neurosurg Psychiatry 78:877-9. 2007
    ..73; p = 0.001) whereas no correlation was found with number of packs of cigarettes per day. Coffee drinking may be inversely associated with the development of primary BSP and this association may partly depend on the amount consumed...
  43. doi request reprint Brain-derived neurotrophic factor and risk for primary adult-onset cranial-cervical dystonia
    D Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Eur J Neurol 16:949-52. 2009
    ..In this study we aimed at exploring the effect of this SNP upon the risk of developing common forms of primary adult-onset dystonia...
  44. pmc Does sex influence age at onset in cranial-cervical and upper limb dystonia?
    G Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    J Neurol Neurosurg Psychiatry 74:265-7. 2003
    ..A significant inverse association between age at the onset of dystonia and education was observed in both cranial-cervical dystonia and upper limb dystonia series...
  45. ncbi request reprint Primary cervical dystonia and scoliosis: a multicenter case-control study
    G Defazio
    Department of Neurologic and Psychiatric Sciences, University of Bari, Italy
    Neurology 60:1012-5. 2003
    ..To study the distribution of prior scoliosis among patients with primary adult-onset cervical dystonia (CD) and matched control subjects...
  46. ncbi request reprint Inhibition of protein kinase C counteracts TNFalpha-induced intercellular adhesion molecule 1 expression and fluid phase endocytosis on brain microvascular endothelial cells
    G Defazio
    Department of Neurologic and Psychiatric Sciences, University of Bari, I 70124, Bari, Italy
    Brain Res 863:245-8. 2000
    ..5-10 nM) did not. These findings indicate that a PKC-dependent mechanism may affect TNFalpha signalling on different barrier properties of BMECs...
  47. ncbi request reprint Serum autoantibodies do not differentiate PANDAS and Tourette syndrome from controls
    R C Dale
    Neurology 66:1612; author reply 1612. 2006
  48. pmc Pain and motor complications in Parkinson's disease
    M Tinazzi
    Dipartimento di Scienze Neurologiche e della Visione, Sezione di Neurologia Riabilitativa, Universita di Verona, Verona, Italy
    J Neurol Neurosurg Psychiatry 77:822-5. 2006
    ..To study the association of pain with motor complications in 117 patients with Parkinson's disease...