Franceso Marotta

Summary

Country: Italy

Publications

  1. ncbi Oxidative-inflammatory damage in cirrhosis: effect of vitamin E and a fermented papaya preparation
    Francesco Marotta
    Hepatogastroenterology Department, S Giuseppe Hospital, Milan, Italy
    J Gastroenterol Hepatol 22:697-703. 2007
  2. ncbi Subclinical candiduria in patients with gastrointestinal malignancies: a preliminary study on the protective effect of a natural phytocompound
    F Marotta
    Immunology Research Institute and Clinic, Nagoya, Japan
    J Biol Regul Homeost Agents 24:317-24. 2010
  3. ncbi Functional foods in genomic medicine: a review of fermented papaya preparation research progress
    Francesco Marotta
    ReGenera Research Group, Milano, Italy
    Acta Biomed 83:21-9. 2012
  4. pmc Effect of an isoflavones-containing red clover preparation and alkaline supplementation on bone metabolism in ovariectomized rats
    S Kawakita
    Biokenkyusho Research Laboratory, Shizuoka, Japan
    Clin Interv Aging 4:91-100. 2009
  5. ncbi NAFLD: a sign of "early aging"?
    Reza Rastamanesh
    ReGenera Research Group for Aging Intervention, Milano, Italy
    Acta Biomed 84:244-5. 2013
  6. ncbi A sturgeon-derived bioactive compound beneficially modulates nuclear receptors controlling metabolic functions in patients with metabolic syndrome
    Francesco Marotta
    ReGenera Research Group for Aging Intervention, Milano, Italy
    Acta Biomed 84:53-60. 2013
  7. ncbi Testing a novel bioactive marine nutraceutical on osteoarthritis patients
    Roberto Catanzaro
    ReGenera Research Group for Aging Intervention
    Acta Biomed 84:30-7. 2013
  8. ncbi Effective properties of a sturgeon-based bioactive compound on stress-induced hippocampal degeneration and on in vitro neurogenesis
    F Marotta
    ReGenera Research Group for Aging Intervention, Milano, Italy
    J Biol Regul Homeost Agents 26:327-35. 2012
  9. ncbi Is there a potential application of a fermented nutraceutical in acute respiratory illnesses? An in-vivo placebo-controlled, cross-over clinical study in different age groups of healthy subjects
    F Marotta
    ReGenera Research Group for Aging Intervention, Milan, Italy
    J Biol Regul Homeost Agents 26:285-94. 2012
  10. doi A phytochemical approach to experimental metabolic syndrome-associated renal damage and oxidative stress
    Francesco Marotta
    ReGenera Res Group for Aging Intervention, Milan, Italy
    Rejuvenation Res 15:153-6. 2012

Collaborators

Detail Information

Publications42

  1. ncbi Oxidative-inflammatory damage in cirrhosis: effect of vitamin E and a fermented papaya preparation
    Francesco Marotta
    Hepatogastroenterology Department, S Giuseppe Hospital, Milan, Italy
    J Gastroenterol Hepatol 22:697-703. 2007
    ..The aim of this study was to test a novel antioxidant/immunomodulator in patients with HCV-related cirrhosis...
  2. ncbi Subclinical candiduria in patients with gastrointestinal malignancies: a preliminary study on the protective effect of a natural phytocompound
    F Marotta
    Immunology Research Institute and Clinic, Nagoya, Japan
    J Biol Regul Homeost Agents 24:317-24. 2010
    ..A therapeutic approach with a natural antifungal phytocompound seems a safe and effective measure and a tentative prophylactic approach might also be envisaged...
  3. ncbi Functional foods in genomic medicine: a review of fermented papaya preparation research progress
    Francesco Marotta
    ReGenera Research Group, Milano, Italy
    Acta Biomed 83:21-9. 2012
    ....
  4. pmc Effect of an isoflavones-containing red clover preparation and alkaline supplementation on bone metabolism in ovariectomized rats
    S Kawakita
    Biokenkyusho Research Laboratory, Shizuoka, Japan
    Clin Interv Aging 4:91-100. 2009
    ..Taken together these data show that red clover preparation in dosages amenable to clinical practice do improve OVX-induced osteoporosis while a mild metabolic alkalosis might further synergize some therapeutic aspects...
  5. ncbi NAFLD: a sign of "early aging"?
    Reza Rastamanesh
    ReGenera Research Group for Aging Intervention, Milano, Italy
    Acta Biomed 84:244-5. 2013
    ..To te Editor,Hamaguchi and colleagues very recently reported aging a risk factor for non-alcoholic fatty liver disease (NAFLD) in premenopausal women, independent of ... ..
  6. ncbi A sturgeon-derived bioactive compound beneficially modulates nuclear receptors controlling metabolic functions in patients with metabolic syndrome
    Francesco Marotta
    ReGenera Research Group for Aging Intervention, Milano, Italy
    Acta Biomed 84:53-60. 2013
    ..Although the metabolic syndrome remains a multifaceted condition requiring a complex approach, LD-1227 could be a potential safe therapeutic tool to be integrated into a wider treatment and preventive medicine schedule strategy. ..
  7. ncbi Testing a novel bioactive marine nutraceutical on osteoarthritis patients
    Roberto Catanzaro
    ReGenera Research Group for Aging Intervention
    Acta Biomed 84:30-7. 2013
    ..LD-1227 brought about also a more significant downregulation of the tested cytokines cascade. Taken overall, these data suggest that LD-1227 has the potential to be included in the nutraceutical armamentarium in the management of OA. ..
  8. ncbi Effective properties of a sturgeon-based bioactive compound on stress-induced hippocampal degeneration and on in vitro neurogenesis
    F Marotta
    ReGenera Research Group for Aging Intervention, Milano, Italy
    J Biol Regul Homeost Agents 26:327-35. 2012
    ....
  9. ncbi Is there a potential application of a fermented nutraceutical in acute respiratory illnesses? An in-vivo placebo-controlled, cross-over clinical study in different age groups of healthy subjects
    F Marotta
    ReGenera Research Group for Aging Intervention, Milan, Italy
    J Biol Regul Homeost Agents 26:285-94. 2012
    ..e., whether it will help reducing the whole respiratory oxidative stress in the human airway and, hopefully, the incidence and/or severity of URTI remains to be demonstrated in longer clinical trials...
  10. doi A phytochemical approach to experimental metabolic syndrome-associated renal damage and oxidative stress
    Francesco Marotta
    ReGenera Res Group for Aging Intervention, Milan, Italy
    Rejuvenation Res 15:153-6. 2012
    ..01). These data suggest the potential clinical benefit of DTS in protecting the kidneys from metabolic syndrome-associated changes; gender-related analysis is under way...
  11. doi Cardioprotective effect of a biofermented nutraceutical on endothelial function in healthy middle-aged subjects
    Francesco Marotta
    ReGenera Res Group for Aging Intervention, Milan, Italy
    Rejuvenation Res 15:178-81. 2012
    ....
  12. doi Beneficial modulation from a high-purity caviar-derived homogenate on chronological skin aging
    Francesco Marotta
    ReGenera Res Group for Aging Intervention, Milan, Italy
    Rejuvenation Res 15:174-7. 2012
    ..05 vs. young control), but this phenomenon was reversed by LD-1227 (p<0.01). These data show that LD-1227 may modify the extracellular matrix milieu in aged skin and also beneficially affect mitochondrial function...
  13. doi Biomarine extracts significantly protect from ultraviolet A-induced skin photoaging: an ex vivo study
    Francesco Marotta
    ReGenera Res Group for Aging Intervention, Milan, Italy
    Rejuvenation Res 15:157-60. 2012
    ....
  14. doi Inhibition of human breast cancer cell growth and enzymatic activity by a fermented nutraceutical: an in vitro and in vivo study
    F Marotta
    Nutraceutical Nutrigenomic Unit, GAIA Age Management Foundation, Pavia, Italy
    Ann N Y Acad Sci 1155:273-7. 2009
    ....
  15. ncbi Nutraceutical strategy in aging: targeting heat shock protein and inflammatory profile through understanding interleukin-6 polymorphism
    F Marotta
    G A I A Age Management Foundation, Pavia, Italy
    Ann N Y Acad Sci 1119:196-202. 2007
    ..A nutraceutical intervention seems able to beneficially modulate such a phenomenon...
  16. ncbi Protective effect of a poly-phytocompound on early stage nephropathy secondary to experimentally-induced diabetes
    F Marotta
    WHO centre for Biotech and Traditional Medicine, University of Milan, Italy
    J Biol Regul Homeost Agents 24:41-9. 2010
    ....
  17. ncbi Effect of a fermented nutraceutical on thioredoxin level and TNF-alpha signalling in cirrhotic patients
    F Marotta
    ReGenera Research Group for Aging Intervention, Milan, Italy
    J Biol Regul Homeost Agents 25:37-45. 2011
    ....
  18. ncbi The aging/precancerous gastric mucosa: a pilot nutraceutical trial
    F Marotta
    Hepato Gastroenterology Unit, S Giuseppe Hospital, Milan, Italy
    Ann N Y Acad Sci 1019:195-9. 2004
    ..05). These data suggest that antioxidant supplementation, and, namely, Immun-Age, might be potential chemopreventive agents in HP-eradicated CAG patients and especially in the elderly population...
  19. ncbi Preventive strategy for Candida gut translocation during ischemia-reperfusion injury supervening on protein-calorie malnutrition
    F Marotta
    WHO Collaborative Center for Traditional Medicine, S Giuseppe Hospital, University of Milan, Milan, Italy
    Chin J Dig Dis 7:33-8. 2006
    ....
  20. ncbi Liver exposure to xenobiotics: the aging factor and potentials for functional foods
    F Marotta
    Hepato Gastroenterology Department, San Giuseppe Hospital, Milan, Italy
    Rejuvenation Res 9:338-41. 2006
    ..These preliminary data suggest that age per se enhances the vulnerability of hepatocytes to xenobiotics, whereas some safe nutraceuticals seem to exert significant protective effects...
  21. ncbi Chemopreventive effect of a probiotic preparation on the development of preneoplastic and neoplastic colonic lesions: an experimental study
    F Marotta
    Hepato Gastroenterology Unit, Medical Science Department S Giuseppe Hospital, Traditional Medicine WHO Center, University of Milan, Milan, Italy
    Hepatogastroenterology 50:1914-8. 2003
    ....
  22. ncbi Improvement of hemorheological abnormalities in alcoholics by an oral antioxidant
    F Marotta
    Hepatogastroenterology Dept, S Giuseppe Hospital, Milano, Italy
    Hepatogastroenterology 48:511-7. 2001
    ..It has been shown that alcohol impairs erythrocyte (red blood cell) membrane fluidity and lipid composition. The aim of this study was to test the effect of a novel acid-resistant antioxidant on the hemorrheology in alcoholics...
  23. ncbi Cyanocobalamin absorption abnormality in alcoholics is improved by oral supplementation with a fermented papaya-derived antioxidant
    F Marotta
    Hepatogastroenterology Dept, S Giuseppe Hospital, Milano, Italy
    Hepatogastroenterology 47:1189-94. 2000
    ..Thirty alcoholic patients and 24 teetotaler dyspeptic patients were considered and underwent baseline blood chemical evaluation and the Schilling test...
  24. ncbi Protective effect of a phytocompound on oxidative stress and DNA fragmentation against paracetamol-induced liver damage
    Francesco Marotta
    University of Milan, Via Pisanello, 4 20146 Milano, Italy
    Ann Hepatol 8:50-6. 2009
    ..lt;br />..
  25. doi "Accelerating aging" chemotherapy on aged animals: protective effect from nutraceutical modulation
    Francesco Marotta
    WHO Center for Biotechnology and Traditional Medicine, University of Milano, Italy
    Rejuvenation Res 11:513-7. 2008
    ..05). Such data suggest that DTS effectively prevents CPX-induced immune suppression and oxidative-inflammatory damage, which are particularly enhanced in aged organisms...
  26. ncbi Relationship between aging and susceptibility of erythrocytes to oxidative damage: in view of nutraceutical interventions
    F Marotta
    GAIA Age Management Foundation, Pavia, Italy
    Rejuvenation Res 9:227-30. 2006
    ..05). These preliminary data suggest that nutraceuticals with antioxidant/NO-regulating properties significantly protect from RBC oxidative damage, and are potential weapons for the aging process and chronic and degenerative diseases...
  27. ncbi Nutraceutical supplementation: effect of a fermented papaya preparation on redox status and DNA damage in healthy elderly individuals and relationship with GSTM1 genotype: a randomized, placebo-controlled, cross-over study
    Franceso Marotta
    Hepatogastroenterology Unit, S Giuseppe Hospital, Milano, Italy
    Ann N Y Acad Sci 1067:400-7. 2006
    ....
  28. ncbi Redox status impairment in liver and kidney of prematurely senescent mice: effectiveness of DTS phytotherapeutic compound
    F Marotta
    WHO Center for Biotechnology and Traditional Medicine, University of Milano, Italy
    Ann N Y Acad Sci 1067:408-13. 2006
    ..05) and tissue concentration of the above parameters (P < 0.05). Such preliminary data suggest that DTS mitigated oxidative damage in PSM, with likely action on the cytoplasm and mitochondrial matrix...
  29. ncbi Phytotherapeutic compound YHK exerts an inhibitory effect on early stage of experimentally-induced neoplastic liver lesions
    F Marotta
    Hepato Gastroenterology Unit, S Giuseppe Hospital, Milan, Italy
    Ann Hepatol 5:268-72. 2006
    ..It is concluded that herbal compound YHK by preventing hepatocarcinogenesis in DEN-induced liver preneoplastic lesions in rats has the potential to a large clinical application as a functional food...
  30. ncbi Experimental acute alcohol pancreatitis-related liver damage and endotoxemia: synbiotics but not metronidazole have a protective effect
    F Marotta
    Hepato Gastroenterology Department, S Giuseppe Hospital, Milan, Italy
    Chin J Dig Dis 6:193-7. 2005
    ..The aim of this study was to test the effect of gut manipulation by either novel synbiotics or by metronidazole on either endotoxemia or the severity of liver damage in the course of acute pancreatitis from alcohol ingestion...
  31. ncbi Anti-inflammatory and neuroprotective effect of a phytoestrogen compound on rat microglia
    F Marotta
    Hepato Gastroenterology Unit, S Giuseppe Hospital, Milan, Italy
    Ann N Y Acad Sci 1089:276-81. 2006
    ..This finding may offer promise in the field of nutraceutical intervention...
  32. ncbi Redox balance signalling in occupational stress: modification by nutraceutical intervention
    F Marotta
    ReGenera Research Group, Milan, Italy
    J Biol Regul Homeost Agents 25:221-9. 2011
    ..Supplementation with functional food affecting redox regulation may be part of the therapeutic armamentarium to be considered in this clinical setting...
  33. ncbi In vitro study on the mechanisms of action of a novel phytotherapeutic compound against human hepatoma cells
    Francesco Marotta
    WHO Cntr for Biotech and Trad Medicine, University of Milano, Italy
    Ann Hepatol 6:111-6. 2007
    ..Given its lack of toxicity so far reported, such natural product might represent an effective nutritional supplement in a number of pathological conditions where a chemopreventive strategy is planned...
  34. doi Muscular metabolism in aged rats under exhaustive exercise: effect of a modified alkaline supplementation
    Francesco Marotta
    GAIA Age Management Foundation, Pavia, Italy
    Rejuvenation Res 11:519-22. 2008
    ..05). This study suggests that MAS can improve fast and endurance muscle metabolism in aged rats by increasing cellular acetyl group availability and tricarboxylic acid turnover...
  35. ncbi Integrating medical knowledge: old roots and a modern science-based approach at the University of Milan
    E Minelli
    WHO Center for Traditional Medical Research in Biotechnology and Natural Medicine, University of Milan, Italy
    Adv Exp Med Biol 546:57-71. 2004
  36. ncbi Probiotics in diverticular disease of the colon: an open label study
    Pepu Lamiki
    TMC Hospital, Shizuoka, Japan
    J Gastrointestin Liver Dis 19:31-6. 2010
    ..To investigate the effectiveness and safety of a symbiotic mixture in preventing recurrence of constipation-related abdominal pain in patients with uncomplicated diverticular disease of the colon...
  37. ncbi Effect of a prebiotic-enriched phytocompound in improving ovalbumin allergenicity
    Yussef Metugriachuk
    Tsuchiya Medical Corporation Hospital, University of Milan, Italy
    Chin J Dig Dis 7:206-10. 2006
    ..The aim of the present study was to test a prebiotic-phytotherapic compound in an experimental model of oral allergenicity...
  38. ncbi Effect of a novel phyto-compound on mucosal candidiasis: further evidence from an ex vivo study
    Juntaro Nakajima
    Nakajima Dental Clinic, Kobe, Japan
    J Dig Dis 8:48-51. 2007
    ..To isolate, identify and determine the prevalence of yeasts in the oral cavity of individuals and to test the minimum inhibitory dilution (MID) of Kolorex against the yeasts isolated...
  39. ncbi Congratulations and cooperation
    Francesco Marotta
    Saudi Med J 25:391; author reply 391. 2004
  40. ncbi Oral administration of Bacillus oligonitrophilus KU-1 may prevent tumors
    Sergey Malkov
    Asian Pac J Cancer Prev 7:343. 2006
  41. ncbi Delta-S entropy variation system: a novel biophysical approach to treat chronic-degenerative processes. The challenge of liver cirrhosis
    Giuseppe Marineo
    Department of Delta Research and Development, Tor Vergata University, Rome, Italy
    Saudi Med J 25:979-82. 2004