Bianca Marchetti

Summary

Country: Italy

Publications

  1. pmc Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair
    Bianca Marchetti
    Department of Clinical and Molecular Biomedicine, Pharmacology Section, Medical School, University of Catania, Catania, Italy
    Eur J Neurosci 37:1550-63. 2013
  2. pmc Wnt your brain be inflamed? Yes, it Wnt!
    Bianca Marchetti
    Department of Clinical and Molecular Biomedicine, Pharmacology Section, Medical School, University of Catania, 95125 Catania, Italy
    Trends Mol Med 19:144-56. 2013
  3. pmc A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection
    Francesca L'Episcopo
    OASI Institute for Research and Care on Mental Retardation and Brain Aging, Neuropharmacology Section Via Conte Ruggero 73, 94018 Troina EN, Italy
    Mol Neurodegener 6:49. 2011
  4. ncbi request reprint To be or not to be (inflamed)--is that the question in anti-inflammatory drug therapy of neurodegenerative disorders?
    Bianca Marchetti
    Department of Pharmacology, University of Sassari Medical School, Sassari, Sardinia, Italy
    Trends Pharmacol Sci 26:517-25. 2005
  5. ncbi request reprint Endogenous melatonin protects L-DOPA from autoxidation in the striatal extracellular compartment of the freely moving rat: potential implication for long-term L-DOPA therapy in Parkinson's disease
    Gaia Rocchitta
    Department of Pharmacology, University of Sassari, Sassari, Italy
    J Pineal Res 40:204-13. 2006
  6. ncbi request reprint Glucocorticoid receptor-nitric oxide crosstalk and vulnerability to experimental parkinsonism: pivotal role for glia-neuron interactions
    Bianca Marchetti
    Neuropharmacology Section, OASI Institute for Research and Care on Mental Retardation and Brain Aging IRCCS, Troina EN Italy
    Brain Res Brain Res Rev 48:302-21. 2005
  7. pmc Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    Francesca L'Episcopo
    OASI Institute for Research and Care on Mental Retardation and Brain Aging IRCCS, Neuropharmacology Section, 94018 Troina, Italy
    J Neuroinflammation 7:83. 2010
  8. pmc Plasticity of subventricular zone neuroprogenitors in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease involves cross talk between inflammatory and Wnt/β-catenin signaling pathways: functional consequences for neuropr
    Francesca L'Episcopo
    OASI Institute for Research and Care on Mental Retardation and Brain Aging, Neuropharmacology Section, 94018 Troina, Italy
    J Neurosci 32:2062-85. 2012
  9. ncbi request reprint Reactive astrocytes are key players in nigrostriatal dopaminergic neurorepair in the MPTP mouse model of Parkinson's disease: focus on endogenous neurorestoration
    Francesca L 'Episcopo
    OASI Institute for Research and Care on Mental Retardation and Brain Aging, Neuropharmacology Section, Troina, Italy
    Curr Aging Sci 6:45-55. 2013
  10. ncbi request reprint Activation of cytosolic phospholipase A2 and 15-lipoxygenase by oxidized low-density lipoproteins in cultured human lung fibroblasts
    Gabriella Lupo
    Department of Biochemistry, University of Catania, Viale Andrea Doria 6, Catania, Italy
    Biochim Biophys Acta 1771:522-32. 2007

Collaborators

Detail Information

Publications26

  1. pmc Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair
    Bianca Marchetti
    Department of Clinical and Molecular Biomedicine, Pharmacology Section, Medical School, University of Catania, Catania, Italy
    Eur J Neurosci 37:1550-63. 2013
    ....
  2. pmc Wnt your brain be inflamed? Yes, it Wnt!
    Bianca Marchetti
    Department of Clinical and Molecular Biomedicine, Pharmacology Section, Medical School, University of Catania, 95125 Catania, Italy
    Trends Mol Med 19:144-56. 2013
    ....
  3. pmc A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection
    Francesca L'Episcopo
    OASI Institute for Research and Care on Mental Retardation and Brain Aging, Neuropharmacology Section Via Conte Ruggero 73, 94018 Troina EN, Italy
    Mol Neurodegener 6:49. 2011
    ..abstract:..
  4. ncbi request reprint To be or not to be (inflamed)--is that the question in anti-inflammatory drug therapy of neurodegenerative disorders?
    Bianca Marchetti
    Department of Pharmacology, University of Sassari Medical School, Sassari, Sardinia, Italy
    Trends Pharmacol Sci 26:517-25. 2005
    ....
  5. ncbi request reprint Endogenous melatonin protects L-DOPA from autoxidation in the striatal extracellular compartment of the freely moving rat: potential implication for long-term L-DOPA therapy in Parkinson's disease
    Gaia Rocchitta
    Department of Pharmacology, University of Sassari, Sassari, Italy
    J Pineal Res 40:204-13. 2006
    ..These results may be of relevance to the long-term L-DOPA therapy of Parkinson's disease...
  6. ncbi request reprint Glucocorticoid receptor-nitric oxide crosstalk and vulnerability to experimental parkinsonism: pivotal role for glia-neuron interactions
    Bianca Marchetti
    Neuropharmacology Section, OASI Institute for Research and Care on Mental Retardation and Brain Aging IRCCS, Troina EN Italy
    Brain Res Brain Res Rev 48:302-21. 2005
    ....
  7. pmc Combining nitric oxide release with anti-inflammatory activity preserves nigrostriatal dopaminergic innervation and prevents motor impairment in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    Francesca L'Episcopo
    OASI Institute for Research and Care on Mental Retardation and Brain Aging IRCCS, Neuropharmacology Section, 94018 Troina, Italy
    J Neuroinflammation 7:83. 2010
    ....
  8. pmc Plasticity of subventricular zone neuroprogenitors in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease involves cross talk between inflammatory and Wnt/β-catenin signaling pathways: functional consequences for neuropr
    Francesca L'Episcopo
    OASI Institute for Research and Care on Mental Retardation and Brain Aging, Neuropharmacology Section, 94018 Troina, Italy
    J Neurosci 32:2062-85. 2012
    ....
  9. ncbi request reprint Reactive astrocytes are key players in nigrostriatal dopaminergic neurorepair in the MPTP mouse model of Parkinson's disease: focus on endogenous neurorestoration
    Francesca L 'Episcopo
    OASI Institute for Research and Care on Mental Retardation and Brain Aging, Neuropharmacology Section, Troina, Italy
    Curr Aging Sci 6:45-55. 2013
    ....
  10. ncbi request reprint Activation of cytosolic phospholipase A2 and 15-lipoxygenase by oxidized low-density lipoproteins in cultured human lung fibroblasts
    Gabriella Lupo
    Department of Biochemistry, University of Catania, Viale Andrea Doria 6, Catania, Italy
    Biochim Biophys Acta 1771:522-32. 2007
    ..It may initially stimulate the fibroblast reaction against the oxidation challenge as well as metabolic repair, such as during lung inflammation and pulmonary fibrosis...
  11. ncbi request reprint Endothelial cell-pericyte cocultures induce PLA2 protein expression through activation of PKCalpha and the MAPK/ERK cascade
    Carmelina Daniela Anfuso
    Department of Biochemistry, University of Catania, 95126 Catania, Italy
    J Lipid Res 48:782-93. 2007
    ....
  12. ncbi request reprint Role of endogenous melatonin in the oxidative homeostasis of the extracellular striatal compartment: a microdialysis study in PC12 cells in vitro and in the striatum of freely moving rats
    Gaia Rocchitta
    Department of Pharmacology, University of Sassari, Sassari, Italy
    J Pineal Res 39:409-18. 2005
    ....
  13. ncbi request reprint Hormones are key actors in gene x environment interactions programming the vulnerability to Parkinson's disease: glia as a common final pathway
    Bianca Marchetti
    OASI Institute for Research and Care on Mental Retardation and Brain Aging IRCCS, Neuropharmacology Section, Via Conte Ruggero 73, 94018 Troina EN, Italy
    Ann N Y Acad Sci 1057:296-318. 2005
    ..Such recognition of endogenous glial protective pathways may provide a new insight and may contribute to the development of novel therapeutic treatment strategies for PD and possibly other neurodegenerative disorders...
  14. pmc Aging-induced Nrf2-ARE pathway disruption in the subventricular zone drives neurogenic impairment in parkinsonian mice via PI3K-Wnt/β-catenin dysregulation
    Francesca L'Episcopo
    Oasi Maria Institute for Research and Care on Mental Retardation and Brain Aging, Neuropharmacology Section, 94018 Troina, Italy
    J Neurosci 33:1462-85. 2013
    ..Last, pharmacological activation/antagonism studies in vivo and in vitro suggest the potential that aged SVZ manipulation is associated with DAergic functional recovery...
  15. ncbi request reprint Activation of phospholipase A(2) and MAP kinases by oxidized low-density lipoproteins in immortalized GP8.39 endothelial cells
    Gabriella Lupo
    Department of Biochemistry, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
    Biochim Biophys Acta 1735:135-50. 2005
    ....
  16. ncbi request reprint Glucocorticoid receptor deficiency increases vulnerability of the nigrostriatal dopaminergic system: critical role of glial nitric oxide
    Maria Concetta Morale
    OASI Institute for Research and Care on Mental Retardation and Brain Aging IRCCS, Neuropharmacology Section, 94018 Troina, Italy
    FASEB J 18:164-6. 2004
    ..The iNOS inhibitor N6-(1-iminoethyl)-L-lysine normalized vulnerability of Tg mice, thus establishing a novel link between genetic impairment of GR function and vulnerability to MPTP...
  17. doi request reprint The MPTP mouse model: cues on DA release and neural stem cell restorative role
    Pier Andrea Serra
    Department of Pharmacology, University of Sassari, Italy
    Parkinsonism Relat Disord 14:S189-93. 2008
    ..Such DA release may be considered the first step in MPTP-induced striatal DA depletion. Reportedly, neural stem cells improve symptoms in the MPTP model of PD by interacting with the MPTP-induced pathological nigrostriatal milieu...
  18. doi request reprint Switching the microglial harmful phenotype promotes lifelong restoration of subtantia nigra dopaminergic neurons from inflammatory neurodegeneration in aged mice
    Francesca L'Episcopo
    OASI Institute for Research and Care on Mental Retardation and Brain Aging, Neuropharmacology Section, Troina, Italy
    Rejuvenation Res 14:411-24. 2011
    ....
  19. ncbi request reprint Glia as a turning point in the therapeutic strategy of Parkinson's disease
    Francesca L' Episcopo
    OASI Institute for Research and Care on Mental Retardation and Brain Aging IRCCS, Neuropharmacology Section, 94018 Troina, Italy
    CNS Neurol Disord Drug Targets 9:349-72. 2010
    ..Dissecting the molecular determinants of glia-neuron crosstalk will give us the possibility to test novel strategies to promote restoration of injured nigrostriatal DAergic neurons...
  20. pmc Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1)
    Florinda Gennuso
    Neuropharmacology Section, OASI Institute for Research and Care on Mental Retardation and Brain Aging, 94018 Troina, Italy
    Proc Natl Acad Sci U S A 101:2470-5. 2004
    ..Our conclusion is that in astrocytes, UCB up-regulates expression of Mrp1 and promotes its trafficking from the Golgi to the plasma membrane, thus moderating cytotoxicity from UCB, presumably by limiting its intracellular accumulation...
  21. ncbi request reprint Exposure to a dysfunctional glucocorticoid receptor from early embryonic life programs the resistance to experimental autoimmune encephalomyelitis via nitric oxide-induced immunosuppression
    Bianca Marchetti
    Department of Pharmacology, University of Sassari Medical School, Sassari, Italy
    J Immunol 168:5848-59. 2002
    ..These findings identify a novel link among GR, NO, and EAE susceptibility and highlight NO as critical signaling molecule in bidirectional communication between the hypothalamic-pituitary-adrenocortical axis and the immune system...
  22. ncbi request reprint Signaling pathways in the nitric oxide and iron-induced dopamine release in the striatum of freely moving rats: role of extracellular Ca2+ and L-type Ca2+ channels
    Gaia Rocchitta
    Department of Pharmacology, University of Sassari, viale S Pietro 43B, 07100 Sassari, Italy
    Brain Res 1047:18-29. 2005
    ....
  23. ncbi request reprint Introduction
    Bianca Marchetti
    Department of Pharmacology, University of Sassari, Medical School, Italy
    Brain Res Brain Res Rev 48:129-32. 2005
  24. ncbi request reprint MAPKs mediate the activation of cytosolic phospholipase A2 by amyloid beta(25-35) peptide in bovine retina pericytes
    Ambra Nicotra
    Department of Biochemistry, University of Catania, Italy
    Biochim Biophys Acta 1733:172-86. 2005
    ....
  25. ncbi request reprint Loss of aromatase cytochrome P450 function as a risk factor for Parkinson's disease?
    M C Morale
    OASI Institute for Research and Care on Mental Retardation and Brain Aging IRCCS, Neuropharmacology Section, 94018 Troina, Italy
    Brain Res Rev 57:431-43. 2008
    ..Characterization of this novel implication of P450 aromatase as determining factor for PD vulnerability may unravel new avenues for the understanding and development of novel therapeutic approaches for Parkinson's disease...
  26. ncbi request reprint Multiple sclerosis and anti-Plasmodium falciparum innate immune response
    Stefano Sotgiu
    Institute of Clinical Neurology, University of Sassari, Viale San Pietro, 10 I 07100, Italy
    J Neuroimmunol 185:201-7. 2007
    ..In conclusion, we have found evidences that some genetic traits formerly selected to confer a protective responses to P. falciparum now partially contribute to the elevated MS susceptibility amongst Sardinians...