Pier M Mannucci

Summary

Country: Italy

Publications

  1. ncbi request reprint Patients with localized and disseminated tumors have reduced but measurable levels of ADAMTS-13 (von Willebrand factor cleaving protease)
    Pier Mannuccio Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Maggiore Hospital and University of Milan, Italy
    Haematologica 88:454-8. 2003
  2. doi request reprint Factors affecting adherence to guidelines for antithrombotic therapy in elderly patients with atrial fibrillation admitted to internal medicine wards
    M Marcucci
    Department of Internal Medicine, University of Perugia, Italy
    Eur J Intern Med 21:516-23. 2010
  3. doi request reprint Thromboprophylaxis in the oldest old with atrial fibrillation: between Scylla and Charybdis
    Pier Mannuccio Mannucci
    Scientific Direction, IRCCS Maggiore Policlinico Hospital Foundation, Milan, Italy
    Eur J Intern Med 24:285-7. 2013
  4. doi request reprint Evolution of the European guidelines for the clinical development of factor VIII products: little progress towards improved patient management
    P M Mannucci
    Scientific Direction, IRCCS Ca Granda Maggiore Policlinico Hospital Foundation, Milan, Italy
    Haemophilia 19:344-8. 2013
  5. doi request reprint Hemostatic defects in liver and renal dysfunction
    Pier Mannuccio Mannucci
    Scientific Direction, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Ca Granda Maggiore Policlinico Hospital Foundation, Milan, Italy
    Hematology Am Soc Hematol Educ Program 2012:168-73. 2012
  6. pmc Past, present and future of hemophilia: a narrative review
    Massimo Franchini
    Immunohematology and Transfusion Center, Department of Pathology and Laboratory Medicine, University Hospital of Parma, Milan, Italy
    Orphanet J Rare Dis 7:24. 2012
  7. doi request reprint How we choose factor VIII to treat hemophilia
    Pier Mannuccio Mannucci
    Scientific Direction, Department of Medicine and Medical Specialties, Istituto di Ricovero eCura a Carattere Scientifico Cá Granda Maggiore Policlinico Hospital Foundation, Milan, Italy
    Blood 119:4108-14. 2012
  8. doi request reprint The role of natural VWF/FVIII complex concentrates in contemporary haemophilia care: a guideline for the next decade
    P M Mannucci
    IRCCS Ca Granda Maggiore Policlinico Hospital Foundation, Milan, Italy
    Haemophilia 18:2-7. 2012
  9. doi request reprint Management of antithrombotic therapy for acute coronary syndromes and atrial fibrillation in patients with hemophilia
    Pier Mannuccio Mannucci
    IRCCS Ca Granda Maggiore Policlinico Hospital Foundation, Via Pace 9, 20122 Milano, Italy
    Expert Opin Pharmacother 13:505-10. 2012
  10. ncbi request reprint Prevention and treatment of major blood loss
    Pier Mannuccio Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and the Department of Medicine and Medical Specialties, University of Milan, Milan
    N Engl J Med 356:2301-11. 2007

Detail Information

Publications116 found, 100 shown here

  1. ncbi request reprint Patients with localized and disseminated tumors have reduced but measurable levels of ADAMTS-13 (von Willebrand factor cleaving protease)
    Pier Mannuccio Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Maggiore Hospital and University of Milan, Italy
    Haematologica 88:454-8. 2003
    ..This observation, which challenges the paradigm that severe ADAMTS-13 deficiency is a specific diagnostic marker for TTP, remains so far unconfirmed...
  2. doi request reprint Factors affecting adherence to guidelines for antithrombotic therapy in elderly patients with atrial fibrillation admitted to internal medicine wards
    M Marcucci
    Department of Internal Medicine, University of Perugia, Italy
    Eur J Intern Med 21:516-23. 2010
    ..However, there are several reports that emphasize the underuse of pharmacological prophylaxis of cardio-embolism in patients with AFF in different health care settings...
  3. doi request reprint Thromboprophylaxis in the oldest old with atrial fibrillation: between Scylla and Charybdis
    Pier Mannuccio Mannucci
    Scientific Direction, IRCCS Maggiore Policlinico Hospital Foundation, Milan, Italy
    Eur J Intern Med 24:285-7. 2013
    ....
  4. doi request reprint Evolution of the European guidelines for the clinical development of factor VIII products: little progress towards improved patient management
    P M Mannucci
    Scientific Direction, IRCCS Ca Granda Maggiore Policlinico Hospital Foundation, Milan, Italy
    Haemophilia 19:344-8. 2013
    ....
  5. doi request reprint Hemostatic defects in liver and renal dysfunction
    Pier Mannuccio Mannucci
    Scientific Direction, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Ca Granda Maggiore Policlinico Hospital Foundation, Milan, Italy
    Hematology Am Soc Hematol Educ Program 2012:168-73. 2012
    ..Particularly in uremia, but also in cirrhosis, thrombosis is becoming a cogent problem...
  6. pmc Past, present and future of hemophilia: a narrative review
    Massimo Franchini
    Immunohematology and Transfusion Center, Department of Pathology and Laboratory Medicine, University Hospital of Parma, Milan, Italy
    Orphanet J Rare Dis 7:24. 2012
    ..Finally, intensive research is devoted to gene transfer therapy, the only way to ultimately obtain cure in hemophilia...
  7. doi request reprint How we choose factor VIII to treat hemophilia
    Pier Mannuccio Mannucci
    Scientific Direction, Department of Medicine and Medical Specialties, Istituto di Ricovero eCura a Carattere Scientifico Cá Granda Maggiore Policlinico Hospital Foundation, Milan, Italy
    Blood 119:4108-14. 2012
    ..Mention is also made to the possible strategies that should be implemented to make available coagulation factors for replacement therapy in developing countries...
  8. doi request reprint The role of natural VWF/FVIII complex concentrates in contemporary haemophilia care: a guideline for the next decade
    P M Mannucci
    IRCCS Ca Granda Maggiore Policlinico Hospital Foundation, Milan, Italy
    Haemophilia 18:2-7. 2012
    ..Methods under investigation to prolong the half-life of factor concentrates offer new hope to reduce the burden of prophylaxis for patients with haemophilia, with early results suggesting greater benefits with FIX...
  9. doi request reprint Management of antithrombotic therapy for acute coronary syndromes and atrial fibrillation in patients with hemophilia
    Pier Mannuccio Mannucci
    IRCCS Ca Granda Maggiore Policlinico Hospital Foundation, Via Pace 9, 20122 Milano, Italy
    Expert Opin Pharmacother 13:505-10. 2012
    ..e., cardiovascular diseases. The peculiarity of the management of these diseases in hemophilia is that antithrombotic drugs impinge on the already compromised hemostasis of these lifelong bleeders...
  10. ncbi request reprint Prevention and treatment of major blood loss
    Pier Mannuccio Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and the Department of Medicine and Medical Specialties, University of Milan, Milan
    N Engl J Med 356:2301-11. 2007
  11. ncbi request reprint Thrombosis and bleeding disorders outside Western countries
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia, Thrombosis Center, Department of Medicine and Medical Specialties, University of Milan and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    J Thromb Haemost 5:68-72. 2007
    ....
  12. ncbi request reprint Desmopressin (DDAVP) and factor VIII: the tale as viewed from Milan (and Malmö)
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and Department of Internal Medicine, Milan, Italy
    J Thromb Haemost 1:622-4. 2003
  13. ncbi request reprint Treatment of hemophilia: recombinant factors only? No
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, Italy
    J Thromb Haemost 1:216-7. 2003
  14. ncbi request reprint Von Willebrand factor cleaving protease (ADAMTS-13) in 123 patients with connective tissue diseases (systemic lupus erythematosus and systemic sclerosis)
    Pier Mannuccio Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Department of Internal Medicine, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
    Haematologica 88:914-8. 2003
    ..We evaluated whether or not ADAMTS-13 deficiency and autoantibodies inactivating the protease prevalent in patients with the prototypic autoimmune diseases systemic lupus erythematosus (SLE) and systemic sclerosis (SSc)...
  15. ncbi request reprint Thrombotic thromboytopenic purpura: another example of immunomediated thrombosis
    Pier Mannuccio Mannucci
    Department of Medicine and Medical Specialties, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milanand IRCCS Maggiore Hospital, Mangiagalli e Regina Elena Foundation, Milan, Italy
    Pathophysiol Haemost Thromb 35:89-97. 2006
    ..Likewise, the value of inducing immune tolerance by regular administrations of ADAMTS13, which will be possible when concentrates of the protease become available, has not been investigated...
  16. ncbi request reprint Abnormal hemostasis tests and bleeding in chronic liver disease: are they related? No
    P M Mannucci
    A Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation and University of Milan, Milan, Italy
    J Thromb Haemost 4:721-3. 2006
  17. ncbi request reprint AIDS, hepatitis and hemophilia in the 1980s: memoirs from an insider
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
    J Thromb Haemost 1:2065-9. 2003
  18. ncbi request reprint Need for randomized trials in hemophilia
    P M Mannucci
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, University of Milan and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    J Thromb Haemost 4:501-2. 2006
  19. ncbi request reprint Overview of bleeding in cancer patients
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
    Pathophysiol Haemost Thromb 33:44-5. 2003
  20. ncbi request reprint Laboratory detection of inherited thrombophilia: a historical perspective
    Pier M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, IRCCS Maggiore Hospital and University of Milan, Italy
    Semin Thromb Hemost 31:5-10. 2005
    ....
  21. ncbi request reprint Tissue plasminogen activator antigen is strongly associated with myocardial infarction in young women
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione Luigi Villa and Department of Internal Medicine and Dermatology, IRCCS Maggiore Hospital and University of Milano, Milano, Italy
    J Thromb Haemost 3:280-6. 2005
    ..66-25.20), respectively. In conclusion, there is a strong association between non-fatal AMI and increased plasma levels of tPA antigen. This finding is thought to be the expression of a reduced rather than enhanced fibrinolytic activity...
  22. ncbi request reprint Management of von Willebrand disease in developing countries
    Pier M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Department of Internal Medicine and Dermatology, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
    Semin Thromb Hemost 31:602-9. 2005
    ..The treatment of patients with antibodies to vWF is also described, and monitoring needs during therapy are reviewed...
  23. ncbi request reprint Plasma levels of von Willebrand factor regulate ADAMTS-13, its major cleaving protease
    Pier Mannuccio Mannucci
    Department of Internal Medicine, Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, IRCCS Maggiore Hospital, University of Milan, Milan, Italy
    Br J Haematol 126:213-8. 2004
    ..These data show that throughout a large spectrum of plasma VWF levels there is a negative association between this protein and the activity of its major cleaving protease...
  24. doi request reprint Factor VIII products and inhibitor development: the SIPPET study (survey of inhibitors in plasma-product exposed toddlers)
    P M Mannucci
    A Bianchi Bonomi Hemophilia and Thrombosis Centre, Department of Medicine and Medical Specialties, University of Milan, Italy
    Haemophilia 13:65-8. 2007
  25. doi request reprint Desmopressin: an historical introduction
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Medicine and Medical Specialties, University of Milan, Italy
    Haemophilia 14:1-4. 2008
    ..This drug has broadened the panel of pharmacological agents that can be used to treat or prevent bleeding in patients with mild hemophilia and von Willebrand disease...
  26. ncbi request reprint The measurement of multifactorial thrombophilia
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, and University of Milan, Italy
    Thromb Haemost 88:1-2. 2002
  27. doi request reprint Old and new anticoagulant drugs: a minireview
    Pier Mannuccio Mannucci
    Scientific Direction, IRCCS Cà Granda Foundation Maggiore Policlinico Hospital, Milan, Italy
    Ann Med 43:116-23. 2011
    ..Lack of specific antidotes for anticoagulation reversal and the high cost are important limitations of their use...
  28. doi request reprint Cardiovascular disease in haemophilia patients: a contemporary issue
    P M Mannucci
    Department of Medicine and Medical Specialities, IRCCS Maggiore Hospital, Milan, Italy
    Haemophilia 16:58-66. 2010
    ..Finally, we present the cases of three elderly haemophilia patients with cardiovascular and other age-related health problems in whom such treatment strategies were applied...
  29. doi request reprint How I treat age-related morbidities in elderly persons with hemophilia
    Pier M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Medicine and Medical Specialties, Istituto di Ricovero e Cura a Carattere Scientifico Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Blood 114:5256-63. 2009
    ....
  30. ncbi request reprint Recessively inherited coagulation disorders
    Pier Mannuccio Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology IRCCS, Maggiore Hospital, University of Milan, Via Pace 9, 20122 Milan, Italy
    Blood 104:1243-52. 2004
    ..The steps and actions necessary to improve the condition of these often neglected patients are outlined...
  31. ncbi request reprint Venous thromboembolism in von Willebrand disease
    P M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Department of Internal Medicine, IRCCS Maggiore Hospital and University of Milan, Italy
    Thromb Haemost 88:378-9. 2002
  32. doi request reprint Global hemostasis tests in patients with cirrhosis before and after prophylactic platelet transfusion
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Clinical Sciences and Community Health, Università degli Studi di, Milano, Milano, Italy
    Liver Int 33:362-7. 2013
    ..However, in vitro studies showed that patients with cirrhosis generate as much thrombin as healthy individuals provided that their platelet count is at least 100 × 10(9) /L...
  33. ncbi request reprint The natural history of hepatitis C virus infection in Italian patients with von Willebrand's disease: a cohort study
    Augusto B Federici
    Angelo Bianchi Bonomi Hemophilia Thrombosis Center, Department of Medical Specialties, IRCCS Maggiore Hospital, Mangiagalli, Regina Elena Foundation, University of Milan, Italy
    Haematologica 91:503-8. 2006
    ..The main objective of this study was to compare the prevalence and outcome of hepatitis C virus (HCV) infection in multi-transfused patients with VWD and in those with hemophilia A or B...
  34. doi request reprint Management of inherited von Willebrand disease in Italy: results from the retrospective study on 1234 patients
    Augusto B Federici
    Division of Hematology and Transfusion Medicine, L SACCO University Hospital and Department of Internal Medicine, University of Milan, Milan, Italy
    Semin Thromb Hemost 37:511-21. 2011
    ..Therefore, evidence-based studies should be organized only in well-characterized patients tested by laboratories that are expert in the clinical, laboratory, and molecular markers of VWD...
  35. doi request reprint Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: a cohort study of 67 patients
    Augusto B Federici
    Angelo Bianchi Bonomi Hemophilia Thrombosis Center, Department of Medicine and Medical Specialties, Istituti di Ricovero e Cura a Carattere Scientifico Maggiore Hospital, University of Milan, Italy
    Blood 113:526-34. 2009
    ..66; 95% confidence interval, 1.03-31.07). Prediction of possible thrombocytopenia in VWD2B by measuring VWF-GPIb-alpha/BC is important because a low platelet count is an independent risk factor for bleeding...
  36. ncbi request reprint ADAMTS13 content in plasma-derived factor VIII/von Willebrand factor concentrates
    Flora Peyvandi
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Center, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Department of Pathophysiology and Transplantation, University of Milan, Luigi Villa Foundation, Milan, Italy
    Am J Hematol 88:895-8. 2013
    ..091 ± 0.007 Units of ADAMTS13 activity per IU of FVIII. On the basis of this analysis and other reports of VWF-FVIII concentrate utilization in congenital TTP, potential dosing, and future clinical developments are discussed...
  37. doi request reprint Acquired coagulation disorders: revisited using global coagulation/anticoagulation testing
    Armando Tripodi
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Department of Internal Medicine, University of Milano Medical School and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milano, Italy
    Br J Haematol 147:77-82. 2009
    ..Thrombin generation assays are more suitable than PT and APTT for use in acquired coagulation defects...
  38. pmc Identification of genetic risk variants for deep vein thrombosis by multiplexed next-generation sequencing of 186 hemostatic/pro-inflammatory genes
    Luca A Lotta
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, U O S Dipartimentale per la Diagnosi e la Terapia delle Coagulopatie, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy
    BMC Med Genomics 5:7. 2012
    ....
  39. ncbi request reprint Treatment of von Willebrand disease with a high-purity factor VIII/von Willebrand factor concentrate: a prospective, multicenter study
    Pier M Mannucci
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Italy
    Blood 99:450-6. 2002
    ..In conclusion, the concentrate effectively stopped active bleeding and provided adequate hemostasis for surgical or invasive procedures, even in the absence of bleeding time correction...
  40. ncbi request reprint Hyperhomocysteinemia in cerebral vein thrombosis
    Ida Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore, University of Milan, Italy
    Blood 102:1363-6. 2003
    ..5 (95% CI, 5.7-67.3). In conclusion, hyperhomocysteinemia is associated with a 4-fold increased risk of cerebral vein thrombosis; whether or not its correction with vitamins reduces the risk of the disease remains to be demonstrated...
  41. doi request reprint Risk factors for postpartum hemorrhage in a cohort of 6011 Italian women
    Eugenia Biguzzi
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Medicine and Medical Specialties, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico and University of Milan, Via Pace 9, 20122 Milan, Italy
    Thromb Res 129:e1-7. 2012
    ..Postpartum hemorrhage is responsible for 25% of maternal pregnancy-related deaths and it is the first cause of maternal morbidity and mortality worldwide...
  42. ncbi request reprint von Willebrand factor: a prima ballerina on two different stages
    Pier M Mannucci
    IRCCS Maggiore Hospital, University of Milan, Milan, Italy
    Semin Hematol 42:1-4. 2005
  43. doi request reprint Effects of CYP2C9 and VKORC1 on INR variations and dose requirements during initial phase of anticoagulant therapy
    Marta Spreafico
    A Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milan and Department of Medicine and Medical Specialties, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Via Pace 9, 20122 Milan, Italy
    Pharmacogenomics 9:1237-50. 2008
    ..However, they have a narrow therapeutic range and show inter- and intra-individual variability in dose requirement, largely conditioned by both environmental and genetic factors...
  44. ncbi request reprint Molecular and functional characterization of a natural homozygous Arg67His mutation in the prothrombin gene of a patient with a severe procoagulant defect contrasting with a mild hemorrhagic phenotype
    Sepideh Akhavan
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital University of Milan, Milan, Italy
    Blood 100:1347-53. 2002
    ..The mild hemorrhagic phenotype might be explained by abnormalities that ultimately counterbalance each other...
  45. doi request reprint Different clinical severity of first episodes and recurrences of thrombotic thrombocytopenic purpura
    Luca A Lotta
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Luigi Villa Foundation, Department of Medicine and Medical Specialities, Universita degli Studi di Milano, Milan, Italy
    Br J Haematol 151:488-94. 2010
    ..Recurrences of TTP are generally milder than first episodes. These differences in severity should be taken into account in clinical research on TTP and in patient management...
  46. ncbi request reprint State of care for hemophilia in pediatric patients
    Elena Santagostino
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
    Paediatr Drugs 4:149-57. 2002
    ..Subcutaneous venous ports have been used in patients with hemophilia if peripheral veins could not be frequently accessed; however, the risk of infection is an important limit to their use...
  47. ncbi request reprint Mild to moderate reduction of a von Willebrand factor cleaving protease (ADAMTS-13) in pregnant women with HELLP microangiopathic syndrome
    Antonella Lattuada
    Immunohematology and Blood Transfusion Service, L Sacco Hospital, Milan, Italy
    Haematologica 88:1029-34. 2003
    ....
  48. ncbi request reprint Advances in the genetics and treatment of von Willebrand disease
    Augusto B Federici
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Department of Internal Medicine, IRCCS Maggiore Hospital, University of Milan, Italy
    Curr Opin Pediatr 14:23-33. 2002
    ..Platelet concentrates or desmopressin can be used as adjunctive treatments when poor correction of the BT after concentrates is associated with continued bleeding...
  49. ncbi request reprint Management of inherited von Willebrand disease in 2007
    Augusto B Federici
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Department of Medicine and Medical Specialities, IRCCS Maggiore Policlinico Hospital, Mangiagalli and Regina Elena Foundation and University of Milan, Milan, Italy
    Ann Med 39:346-58. 2007
    ..In type 3 and in severe forms of types 1 and 2 VWD, DDAVP is not effective and plasma virally inactivated VWF concentrates should be used in bleedings, surgery, and secondary long-term prophylaxis...
  50. ncbi request reprint von Willebrand factor cleaving protease (ADAMTS-13) and ADAMTS-13 neutralizing autoantibodies in 100 patients with thrombotic thrombocytopenic purpura
    Flora Peyvandi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, IRCCS Maggiore Hospital and University of Milano, Milan, Italy
    Br J Haematol 127:433-9. 2004
    ..In conclusion, this study indicated that ADAMTS-13 was normal in nearly one-third of patients with TTP and that ADAMTS-13 deficiency was not associated with the presence of neutralizing antibodies in more than half of the patients...
  51. ncbi request reprint Biologic response to desmopressin in patients with severe type 1 and type 2 von Willebrand disease: results of a multicenter European study
    Augusto B Federici
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, IRCCS Maggio e Hospital and University of Milan, Italy
    Blood 103:2032-8. 2004
    ..This prospective study showed that the rate of biologic response to DDAVP is relatively low not only in type 2 but also in type 1 VWD when uniform and stringent criteria for patient selection and responsiveness are applied...
  52. ncbi request reprint Myocardial infarction in the young: a sex-based comparison
    Fabiola B Sozzi
    Medicine and Medical Specialities Department, IRCCS Maggiore Hospital, M R E Foundation and University of Milan, Milan, Italy
    Coron Artery Dis 18:429-31. 2007
    ..05). In conclusion, young patients with a first acute myocardial infarction risk factors profile and extent of coronary artery lesions were significantly different between sexes...
  53. ncbi request reprint Gene mutations and three-dimensional structural analysis in 13 families with severe factor X deficiency
    Flora Peyvandi
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Luigi Villa Foundation, IRCCS Maggiore Hospital and University of Milan, Via Pace, 9 20122 Milan, Italy
    Br J Haematol 117:685-92. 2002
    ..These novel homozygous FX mutations were consistent with their phenotypes and agree with experimental data from knockout mice, indicating that FX is an essential protein for survival...
  54. doi request reprint An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis
    Armando Tripodi
    Department of Internal Medicine and Medical Specialties, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy
    Gastroenterology 137:2105-11. 2009
    ..We investigated whether plasma from cirrhotic patients has an imbalance of pro- vs anti-coagulation factors...
  55. ncbi request reprint Von Willebrand's disease in the year 2003: towards the complete identification of gene defects for correct diagnosis and treatment
    Giancarlo Castaman
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Italy
    Haematologica 88:94-108. 2003
    ..Bleeding manifestations are heterogeneous: mucosal bleeding is typical of all VWD cases but hemarthrosis and hematomas may also be present when FVIII levels are low...
  56. doi request reprint ADAMTS13 and anti-ADAMTS13 antibodies as markers for recurrence of acquired thrombotic thrombocytopenic purpura during remission
    Flora Peyvandi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milan, Department of Medicine and Medical Specialities, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Luigi Villa Foundation, Milan, Italy
    Haematologica 93:232-9. 2008
    ..From 20 to 50% of patients who survive an acute episode of the acquired form of thrombotic thrombocytopenic purpura relapse but clinical and laboratory markers of recurrence are not well established...
  57. ncbi request reprint Diagnosis and management of acquired von Willebrand syndrome
    Augusto B Federici
    Angelo Bianchi Bonomi Hemophilia Thrombosis Center, University of Milan, Milano, Italy
    Clin Adv Hematol Oncol 1:169-75. 2003
    ..Acquired von Willebrand syndrome, although rare, warrants further understanding for clinical practice...
  58. ncbi request reprint A sensitive ristocetin co-factor activity assay with recombinant glycoprotein Ibalpha for the diagnosis of patients with low von Willebrand factor levels
    Augusto B Federici
    Angelo Bianchi Bonomi Hemophilia Thrombosis Center, Department of Internal Medicine and Dermatology, IRCCS Maggiore Hospital and University of Milan, Italy
    Haematologica 89:77-85. 2004
    ..A correct diagnosis of VWD relies on platelet agglutination tests that have a low accuracy within and between assays. A more accurate VWF:RCo assay would improve VWD diagnosis and classification...
  59. ncbi request reprint Inherited risk factors for venous thromboembolism
    Ida Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy
    Nat Rev Cardiol 11:140-56. 2014
    ..In this Review, we discuss the main causes of inherited thrombophilia, the associated clinical manifestations, and the implications for antithrombotic prophylaxis in the affected individuals. ..
  60. ncbi request reprint Low risk of thrombosis in family members of patients with hyperhomocysteinaemia
    Ida Martinelli
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Luigi Villa Foundation, IRCCS Maggiore Hospital and University of Milan, Via Pace 9, 20122 Milan, Italy
    Br J Haematol 117:709-11. 2002
    ..28% and 0.24%). The low prevalence of hyperhomocysteinaemia among relatives of patients with this metabolic disorder, and their low risk of thrombosis, do not justify family screening...
  61. doi request reprint Feasibility of prophylaxis and immune tolerance induction regimens in haemophilic children using fully implantable central venous catheters
    Maria Elisa Mancuso
    Department of Medicine and Medical Specialities, Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation and University of Milan, Milan, Italy
    Br J Haematol 141:689-95. 2008
    ..This study showed that ports improved the feasibility of prophylaxis in the majority of non-inhibitor children, while they were not suitable for inhibitor children who require a prolonged ITI regimen with daily infusions...
  62. ncbi request reprint A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism
    Armando Tripodi
    Angelo Bianchi Bonomi, Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Blood 104:3631-4. 2004
    ..In conclusion, hypercoagulability detected by a shortened APTT is independently associated with VTE. This inexpensive and simple test should be considered in the evaluation of the risk of VTE...
  63. doi request reprint High levels of factor VIII and risk of extra-hepatic portal vein obstruction
    Ida Martinelli
    Department of Internal Medicine and Medical Specialties, A Bianchi Bonomi Hemophilia and Thrombosis Center and Gastroenterology Unit, University of Milan and IRCCS Maggiore Hospital, Milan, Italy
    J Hepatol 50:916-22. 2009
    ..High levels of coagulation factor VIII are a risk factor for lower-limb deep vein thrombosis (DVT). Their role in extra-hepatic portal vein obstruction (EHPVO) is not established...
  64. doi request reprint Factors influencing the long-term outcome of primary total knee replacement in haemophiliacs: a review of 116 procedures at a single institution
    Luigi P Solimeno
    Haemophilic Arthropathy Treatment Centre M G Gatti Randi, CTO Hospital, Milan, Italy
    Br J Haematol 145:227-34. 2009
    ..These results show that TKR represents a safe and effective procedure in haemophiliacs if performed by a highly experienced surgeon...
  65. doi request reprint The coagulopathy of cirrhosis assessed by thromboelastometry and its correlation with conventional coagulation parameters
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University and IRCCS Ospedale Maggiore, Mangiagalli and Regina Elena Foundation, Milano, Italy
    Thromb Res 124:132-6. 2009
    ..The technique is used as a near-patient-testing device to guide transfusion in cardiac surgery or liver transplantation and less to investigate hemostasis in acquired or congenital coagulopathies...
  66. ncbi request reprint Molecular defects in type 3 von Willebrand disease: updated results from 40 multiethnic patients
    Luciano Baronciani
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, IRCCS Maggiore Hospital and University of Milan, Italy
    Blood Cells Mol Dis 30:264-70. 2003
    ..This study extend our previous finding that mutations responsible for type 3 VWD are scattered throughout the entire VWF gene and that there is no founder effect in these three populations studied...
  67. ncbi request reprint The P303T mutation in the human factor VII (FVII) gene alters the conformational state of the enzyme and causes a severe functional deficiency
    Flora Peyvandi
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Fondazione Luigi Villa, IRCCS Maggiore Hospital and University of Milan, 9 20122 Milan, Italy
    Br J Haematol 127:576-84. 2004
    ..Altogether, these defects may explain the severe bleeding symptoms in a patient carrying the FVIIP303T mutation...
  68. doi request reprint Mechanism of hemostasis defects and management of bleeding in patients with acute coronary syndromes
    Pier Mannuccio Mannucci
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Medicine and Medical Specialties, IRCCS Cà Granda Foundation Maggiore Policlinico Hospital, Milan, Italy
    Eur J Intern Med 21:254-9. 2010
    ..In conclusion, evidence-based recommendations for the management of bleeding in patients with ACS are currently lacking, so that prevention through accurate assessment of the individual risk is the most valid strategy...
  69. ncbi request reprint Factor XI deficiency in Iranians: its clinical manifestations in comparison with those of classic hemophilia
    Flora Peyvandi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, IRCCS Maggiore Hospital and University of Milan, Italy
    Haematologica 87:512-4. 2002
    ..Patients affected by Hodgkin's disease (HD) resistant to induction therapy or who have a brief duration of first remission have a poor outcome...
  70. ncbi request reprint Environmental risk factors for inhibitor development in children with haemophilia A: a case-control study
    Elena Santagostino
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Department of Internal Medicine and Dermatology, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation and University of Milan, Milan, Italy
    Br J Haematol 130:422-7. 2005
    ..2, 95% confidence interval 0.06-0.9). The protective effect on inhibitor development shown by prophylaxis may represent an additional advantage prompting its use in haemophilic children...
  71. ncbi request reprint Incidence of thrombotic complications in patients with haematological malignancies with central venous catheters: a prospective multicentre study
    Agostino Cortelezzi
    Department of Haematology and Bone Marrow Transplantation Unit, IRCCS Fondazione Ospedale Maggiore Policlinico and University of Milan, Milan, Italy
    Br J Haematol 129:811-7. 2005
    ..This study shows that the impact on clinical practice of symptomatic CVC-related thrombotic complications is not negligible in patients with haematological malignancies...
  72. ncbi request reprint Solvent/detergent plasma for prevention of bleeding in recessively inherited coagulation disorders: dosing, pharmacokinetics and clinical efficacy
    Elena Santagostino
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Medicine and Medical Specialities, University of Milan, RCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Italy
    Haematologica 91:634-9. 2006
    ....
  73. ncbi request reprint Arg2074Cys missense mutation in the C2 domain of factor V causing moderately severe factor V deficiency: molecular characterization by expression of the recombinant protein
    Stefano Duga
    Department of Biology and Genetics for Medical Sciences, University of Milan, Italy
    Blood 101:173-7. 2003
    ..These findings, beside confirming the structural and functional importance of the arginine 2074 residue, demonstrate that its substitution with a cysteine impairs both FV secretion and activity...
  74. ncbi request reprint Embryo implantation after assisted reproductive procedures and maternal thrombophilia
    Ida Martinelli
    A Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milano, Via Pace, 9, 20122 Milano, Italy
    Haematologica 88:789-93. 2003
    ....
  75. ncbi request reprint Point-of-care coagulation monitors calibrated for the international normalized ratio for cirrhosis (INRliver) can help to implement the INRliver for the calculation of the MELD score
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Medical Specialties, University and IRCCS Ospedale Maggiore, Mangiagalli and Regina Elena Foundation, Via Pace 9, 20122 Milan, Italy
    J Hepatol 51:288-95. 2009
    ..This study aimed to assess whether easy-to-run whole-blood coagulation monitors (widely used for patients on VKA) can be calibrated to measure efficiently the INR(liver) and minimize the interlaboratory variability...
  76. pmc Hypercoagulability in splenectomized thalassemic patients detected by whole-blood thromboelastometry, but not by thrombin generation in platelet-poor plasma
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Haematologica 94:1520-7. 2009
    ..They might be related to the effects of red blood cell or endothelial cell derangements, increased numbers of platelets as well as abnormal plasma coagulation...
  77. ncbi request reprint Risk of venous thromboembolism after air travel: interaction with thrombophilia and oral contraceptives
    Ida Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Istituto di Ricovero e Cura a Carattere Scientifico, Maggiore Hospital, University of Milan, Milan, Italy
    Arch Intern Med 163:2771-4. 2003
    ..To our knowledge, there are no studies investigating whether individuals with thrombophilia and those taking oral contraceptives are more likely to develop venous thromboembolism during flights than those without these risk factors...
  78. ncbi request reprint Effect of abciximab on prothrombin activation and thrombin generation in patients with acute myocardial infarction also receiving reteplase
    Piera Angelica Merlini
    Division of Cardiology, Ospedale Niguarda, Milan, Italy
    Am J Cardiol 93:195-8. 2004
    ....
  79. ncbi request reprint Analysis of Iranian patients allowed the identification of the first truncating mutation in the fibrinogen Bbeta-chain gene causing afibrinogenemia
    Rosanna Asselta
    Department of Biology and Genetics for Medical Sciences, University of Milan, via Viotti 3 5, 20133 Milan, Italy
    Haematologica 87:855-9. 2002
    ..The aim of this work was to widen knowledge about the mutational spectrum of this disease by analyzing the molecular bases of congenital afibrinogenemia in three unrelated Iranian patients...
  80. doi request reprint Abnormalities of hemostasis and bleeding in chronic liver disease: the paradigm is challenged
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University Medical School and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Intern Emerg Med 5:7-12. 2010
    ..In this article, we review recent evidence from the literature that disputes the above paradigm, and opens new venues for laboratory/clinical research and patient management in this field...
  81. ncbi request reprint Laboratory diagnosis of lupus anticoagulants for patients on oral anticoagulant treatment. Performance of dilute Russell viper venom test and silica clotting time in comparison with Staclot LA
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Thromb Haemost 88:583-6. 2002
    ..Advantages of SCT and Drvvt over Staclot LA are easy automation, no need for normal plasma and relatively low cost...
  82. doi request reprint Association and functional analyses of MEF2A as a susceptibility gene for premature myocardial infarction and coronary artery disease
    Ilaria Guella
    Department of Biology and Genetics for Medical Sciences, University of Milan, via Viotti 3 5, Milan, Italy
    Circ Cardiovasc Genet 2:165-72. 2009
    ..However, the association of MEF2A with coronary artery disease/MI was not confirmed in other studies. We analyzed the role of MEF2A in the pathogenesis of MI in 2008 Italian patients with premature MI and in 2008 controls...
  83. ncbi request reprint Determination of total homocysteine in plasma: comparison of the Abbott IMx immunoassay with high performance liquid chromatography
    Maddalena Loredana Zighetti
    Department of Internal Medicine, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milan, Via Pace 9, 20122 Milan, Italy
    Haematologica 87:89-94. 2002
    ..The aim of this study was to compare the performance of a commercially available IMx immunoassay with that of a reversed-phase high performance liquid chromatography (HPLC) method for measuring plasma total homocysteine (tHcy)...
  84. ncbi request reprint Psychological impact of thrombosis in the young
    Diletta Fiandaca
    Department of Medicine and Medical Specialties, Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, University of Milan and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Intern Emerg Med 1:119-26. 2006
    ..This study was meant to increase the understanding of self-perception, social and family functioning and ways of coping with the disease in young patients after an episode of thrombosis...
  85. ncbi request reprint Inherited thrombophilia and first venous thromboembolism during pregnancy and puerperium
    Ida Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Italy
    Thromb Haemost 87:791-5. 2002
    ..Among thrombophilic abnormalities, the prothrombin mutation was the weakest risk factor. Thrombosis occurred more frequently in puerperium than in pregnancy, whether or not thrombophilia was diagnosed...
  86. ncbi request reprint Clinical and molecular characterization of 6 patients affected by severe deficiency of coagulation factor V: Broadening of the mutational spectrum of factor V gene and in vitro analysis of the newly identified missense mutations
    Maria Claudia Montefusco
    Department of Biology and Genetics for Medical Sciences, University of Milan, Italy
    Blood 102:3210-6. 2003
    ..The high number of "private" mutations identified in FV-deficient families indicates that full mutational screening of FV gene is still required for molecular diagnosis...
  87. ncbi request reprint Cost of care and quality of life for patients with hemophilia complicated by inhibitors: the COCIS Study Group
    Alessandro Gringeri
    Angelo Bianchi Bonomi Hemphilia and Thrombosis Center, University of Milan, Italy
    Blood 102:2358-63. 2003
    ..This study shows that hemophilia complicated by inhibitors, a prototype of rare disease, requires high amounts of resources for management that provides a satisfactory quality of life...
  88. ncbi request reprint Antibodies to tissue-type plasminogen activator (tPA) in patients with antiphospholipid syndrome: evidence of interaction between the antibodies and the catalytic domain of tPA in 2 patients
    Massimo Cugno
    Department of Internal Medicine and Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Via Pace 15, 20122 Milano, Italy
    Blood 103:2121-6. 2004
    ..Our data indicate that anti-tPA antibodies specifically interacting with the catalytic domain of tPA can be found in patients with APS, representing a possible cause of hypofibrinolysis...
  89. doi request reprint Italian Registry of Haemophilia and Allied Disorders. Objectives, methodology and data analysis
    A Iorio
    Hemophilia Centre, Internaland Vascular Medicine, University of Perugia, 06131 Perugia, Italy
    Haemophilia 14:444-53. 2008
    ..The Italian registry run by AICE adds to the list of the available national haemophilia registries and is intended to establish treatment guidelines and foster research projects in Italy...
  90. ncbi request reprint Missense or splicing mutation? The case of a fibrinogen Bbeta-chain mutation causing severe hypofibrinogenemia
    Rosanna Asselta
    Department of Biology and Genetics for Medical Sciences, University of Milan, Milan, Italy
    Blood 103:3051-4. 2004
    ..This represents the first exonic splicing mutation identified in the fibrinogen genes. These findings strengthen the importance to analyze potentially pathogenetic nucleotide variations at both the protein and the mRNA level...
  91. ncbi request reprint Lupus anticoagulants and their relationship with the inhibitors against coagulation factor VIII: considerations on the differentiation between the 2 circulating anticoagulants
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, University and Foundation IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Clin Chem 51:1883-5. 2005
  92. ncbi request reprint N-terminal pro-brain natriuretic peptide on admission has prognostic value across the whole spectrum of acute coronary syndromes
    Marcello Galvani
    Ospedale G B Morgagni and Fondazione Sacco, Forli, Italy
    Circulation 110:128-34. 2004
    ..We measured N-terminal pro-brain natriuretic peptide (NT-proBNP) on admission in patients with ACS and ECG evidence of myocardial ischemia...
  93. ncbi request reprint Clinical and laboratory patterns of the haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura in southern Iran
    Mehran Karimi
    Haemostasis and Thrombosis Unit, Haematology Research Centre, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
    Intern Emerg Med 1:35-9. 2006
    ....
  94. ncbi request reprint Risk factors and recurrence rate of primary deep vein thrombosis of the upper extremities
    Ida Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore Policlinico, University of Milano, Italy
    Circulation 110:566-70. 2004
    ..Risk factors for primary upper-extremity DVT are not well established, and the recurrence rate is unknown...
  95. ncbi request reprint Plasma levels of the von Willebrand factor-cleaving protease in physiological and pathological conditions in children
    Kaan Kavakli
    Ege University Hospital, Department of Pediatric Hematology, Izmir, Turkey
    Pediatr Hematol Oncol 19:467-73. 2002
    ..In conclusion, low protease levels are far from being a specific beacon for TTP. The current paradigm that a single laboratory test may enable physicians to distinguish TTP from HUS seems to be challenged by these and other findings...
  96. ncbi request reprint The thrombogram in rare inherited coagulation disorders: its relation to clinical bleeding
    Raed Al Dieri
    Synapse Laboratory, Cardiovascular Research Institute CARIM, P O Box 616, 6200 MD, University of Maastricht, The Netherlands
    Thromb Haemost 88:576-82. 2002
    ..The one exception was a patient with factor VII deficiency and severe bleeding, who showed a normal ETP value, albeit with a decreased peak height and a prolonged lag-time...
  97. ncbi request reprint Pharmacogenetic aspects of the use of oral contraceptives and the risk of thrombosis
    Ida Martinelli
    A Bianchi Bonomi Haemophilia and Thrombosis Center, IRCCS Ospedale Maggiore and University of Milan, Italy
    Pharmacogenetics 13:589-94. 2003
    ....
  98. ncbi request reprint von Willebrand factor cleaving protease (ADAMTS13) is deficient in recurrent and familial thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
    Giuseppe Remuzzi
    Mario Negri Institute for Pharmacological Research, Clinical Research Center for Rare Diseases, Aldo e Cele Daccò, Villa Camozzi Ranica, Bergamo, Italy
    Blood 100:778-85. 2002
    ..In conclusion, deficient ADAMTS13 activity does not distinguish TTP from HUS, at least in the recurrent and familial forms, and it is not the only determinant of VWF abnormalities in these conditions...
  99. ncbi request reprint Oral contraceptive use, thrombophilia and their interaction in young women with ischemic stroke
    Ida Martinelli
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, University of Milan and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Italy
    Haematologica 91:844-7. 2006
    ..The risk of ischemic stroke in oral contraceptive users was 13 times higher in women who were also carriers of factor V Leiden and 9 times higher in those who also had hyperhomocysteinemia...
  100. ncbi request reprint Epitope mapping of ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura
    Christoph Klaus
    Baxter BioScience, Biomedical Research Center, Uferstrasse 15, 2304 Orth Donau, Austria
    Blood 103:4514-9. 2004
    ..In conclusion, this study shows that even though anti-ADAMTS13 autoantibodies react with multiple domains of the protease, the cys-rich/spacer domain is consistently involved in antibody reactivity...
  101. doi request reprint Interactions between genotype and phenotype in bleeding and thrombosis
    Massimo Franchini
    Haematologica 93:649-52. 2008
    ..1 Examples of interactions between genotype and phenotype in both hemorrhagic and thrombotic disorders are given in this article...