Mirko Manetti

Summary

Country: Italy

Publications

  1. doi request reprint Association of a functional polymorphism in the matrix metalloproteinase-12 promoter region with systemic sclerosis in an Italian population
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Viale G B Morgagni 85, I 50134, Florence, Italy
    J Rheumatol 37:1852-7. 2010
  2. pmc Decreased expression of the endothelial cell-derived factor EGFL7 in systemic sclerosis: potential contribution to impaired angiogenesis and vasculogenesis
    Mirko Manetti
    Arthritis Res Ther 15:R165. 2013
  3. doi request reprint Evidence for progressive reduction and loss of telocytes in the dermal cellular network of systemic sclerosis
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, I 50134 Florence, Italy
    J Cell Mol Med 17:482-96. 2013
  4. doi request reprint Differential expression of junctional adhesion molecules in different stages of systemic sclerosis
    Mirko Manetti
    Azienda Ospedaliero Universitaria Careggi AOUC, Excellence Centre for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies DENOThe, Department of Anatomy, Histology, and Forensic Medicine, University of Florence, Florence, Italy
    Arthritis Rheum 65:247-57. 2013
  5. ncbi request reprint Impaired angiogenesis in systemic sclerosis: the emerging role of the antiangiogenic VEGF(165)b splice variant
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, 50134 Florence, Italy
    Trends Cardiovasc Med 21:204-10. 2011
  6. doi request reprint Increased serum levels and tissue expression of matrix metalloproteinase-12 in patients with systemic sclerosis: correlation with severity of skin and pulmonary fibrosis and vascular damage
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Florence, Italy
    Ann Rheum Dis 71:1064-72. 2012
  7. doi request reprint Evidence for caveolin-1 as a new susceptibility gene regulating tissue fibrosis in systemic sclerosis
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Florence, Italy
    Ann Rheum Dis 71:1034-41. 2012
  8. doi request reprint Overexpression of VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, leads to insufficient angiogenesis in patients with systemic sclerosis
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Viale G B Morgagni 85, Florence, Italy
    Circ Res 109:e14-26. 2011
  9. doi request reprint A genetic variation located in the promoter region of the UPAR (CD87) gene is associated with the vascular complications of systemic sclerosis
    Mirko Manetti
    University of Florence and Excellence Centre for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies, Florence, Italy
    Arthritis Rheum 63:247-56. 2011
  10. ncbi request reprint Mechanisms in the loss of capillaries in systemic sclerosis: angiogenesis versus vasculogenesis
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Florence, Italy
    J Cell Mol Med 14:1241-54. 2010

Collaborators

Detail Information

Publications29

  1. doi request reprint Association of a functional polymorphism in the matrix metalloproteinase-12 promoter region with systemic sclerosis in an Italian population
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Viale G B Morgagni 85, I 50134, Florence, Italy
    J Rheumatol 37:1852-7. 2010
    ..To investigate the possible implication of the matrix metalloproteinase-12 (MMP-12) gene in the genetic predisposition to systemic sclerosis (SSc) susceptibility and clinical phenotype...
  2. pmc Decreased expression of the endothelial cell-derived factor EGFL7 in systemic sclerosis: potential contribution to impaired angiogenesis and vasculogenesis
    Mirko Manetti
    Arthritis Res Ther 15:R165. 2013
    ..In this study, we investigated the possible involvement of EGFL7 in SSc...
  3. doi request reprint Evidence for progressive reduction and loss of telocytes in the dermal cellular network of systemic sclerosis
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, I 50134 Florence, Italy
    J Cell Mol Med 17:482-96. 2013
    ....
  4. doi request reprint Differential expression of junctional adhesion molecules in different stages of systemic sclerosis
    Mirko Manetti
    Azienda Ospedaliero Universitaria Careggi AOUC, Excellence Centre for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies DENOThe, Department of Anatomy, Histology, and Forensic Medicine, University of Florence, Florence, Italy
    Arthritis Rheum 65:247-57. 2013
    ..This study was undertaken to investigate the possible role of JAMs in SSc pathogenesis...
  5. ncbi request reprint Impaired angiogenesis in systemic sclerosis: the emerging role of the antiangiogenic VEGF(165)b splice variant
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, 50134 Florence, Italy
    Trends Cardiovasc Med 21:204-10. 2011
    ....
  6. doi request reprint Increased serum levels and tissue expression of matrix metalloproteinase-12 in patients with systemic sclerosis: correlation with severity of skin and pulmonary fibrosis and vascular damage
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Florence, Italy
    Ann Rheum Dis 71:1064-72. 2012
    ..To determine serum concentrations and tissue expression of matrix metalloproteinase-12 (MMP-12) and their correlation with clinical features in patients with systemic sclerosis (SSc)...
  7. doi request reprint Evidence for caveolin-1 as a new susceptibility gene regulating tissue fibrosis in systemic sclerosis
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Florence, Italy
    Ann Rheum Dis 71:1034-41. 2012
    ..The aim of the study was to analyse the possible association of CAV1 gene single nucleotide polymorphisms (SNP) with SSc...
  8. doi request reprint Overexpression of VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, leads to insufficient angiogenesis in patients with systemic sclerosis
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Viale G B Morgagni 85, Florence, Italy
    Circ Res 109:e14-26. 2011
    ....
  9. doi request reprint A genetic variation located in the promoter region of the UPAR (CD87) gene is associated with the vascular complications of systemic sclerosis
    Mirko Manetti
    University of Florence and Excellence Centre for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders for the Development of Novel Therapies, Florence, Italy
    Arthritis Rheum 63:247-56. 2011
    ..We undertook this study to investigate whether UPAR gene promoter polymorphisms might be associated with SSc phenotypes in the European Caucasian population...
  10. ncbi request reprint Mechanisms in the loss of capillaries in systemic sclerosis: angiogenesis versus vasculogenesis
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Florence, Italy
    J Cell Mol Med 14:1241-54. 2010
    ..Either angiogenic or vasculogenic mechanisms may potentially become in the future the target of therapeutic strategies to promote capillary regeneration in SSc...
  11. ncbi request reprint A loss of telocytes accompanies fibrosis of multiple organs in systemic sclerosis
    Mirko Manetti
    Department of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence, Florence, Italy
    J Cell Mol Med 18:253-62. 2014
    ..As telocytes are believed to be key players in the regulation of tissue/organ homoeostasis, our data suggest that telocyte loss might have important pathophysiological implications in SSc. ..
  12. doi request reprint Bone marrow-derived mesenchymal stem cells from early diffuse systemic sclerosis exhibit a paracrine machinery and stimulate angiogenesis in vitro
    Serena Guiducci
    Department of Biomedicine, Division of Rheumatology, AOUC, Excellence Centre for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Ann Rheum Dis 70:2011-21. 2011
    ....
  13. doi request reprint The IL1-like cytokine IL33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Viale G B Morgagni 85, 50134 Florence, Italy
    Ann Rheum Dis 69:598-605. 2010
    ..Interleukin 33 (IL33) is a novel member of the IL1 family that promotes Th2 responses and inflammation through the ST2 receptor. IL33 is also a chromatin-associated transcriptional regulator in ECs...
  14. ncbi request reprint The genetics of systemic sclerosis: an update
    Eloisa Romano
    Department of Biomedicine, Division of Rheumatology, University of Florence, AOUC, Florence, Italy
    Clin Exp Rheumatol 29:S75-86. 2011
    ..We also discuss the most relevant data obtained in genetic association studies of large populations that included a replication strategy, or studies for which independent replication was available...
  15. doi request reprint Stiff skin syndrome: evidence for an inflammation-independent fibrosis?
    Serena Guiducci
    Department of Biomedicine, Division of Rheumatology, Denothe Centre, University of Florence, AOUC, Florence, Italy
    Rheumatology (Oxford) 48:849-52. 2009
    ..Our aim was to analyse the expression of extracellular matrix (ECM) molecules and pro-fibrotic cytokines in the dermis and epidermis of SSS...
  16. ncbi request reprint Severe fibrosis and increased expression of fibrogenic cytokines in the gastric wall of systemic sclerosis patients
    Mirko Manetti
    University of Florence, Florence, Italy
    Arthritis Rheum 56:3442-7. 2007
    ..The present study was undertaken to evaluate the fibrotic process and the expression of fibrogenic cytokines in the gastric wall of SSc patients with gastroesophageal involvement...
  17. ncbi request reprint The gastric wall in systemic sclerosis patients: a morphological study
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Florence, Italy
    Ital J Anat Embryol 115:115-21. 2010
    ..This study provides evidence for a prominent fibrosis and severe ultrastructural alterations of smooth muscle cells and nerve fibres as the main histopathological hallmarks in the gastric wall of systemic sclerosis patients...
  18. doi request reprint HLA-B27 transgenic rat: an animal model mimicking gut and joint involvement in human spondyloarthritides
    Anna Franca Milia
    Department of Biomedicine, Division of Rheumatology DENOTHE, Center for the Study at the Molecular and Clinical Level of Chronic, Degenerative, and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy
    Ann N Y Acad Sci 1173:570-4. 2009
    ..The purpose of this article is to review the contribution of studies on the HLA-B27 transgenic rat model aimed to elucidate the intimate relationship between gut and joint involvement in SpA...
  19. doi request reprint Progressive loss of lymphatic vessels in skin of patients with systemic sclerosis
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Viale G B Morgagni 85, I 50134, Florence, Italy
    J Rheumatol 38:297-301. 2011
    ..Our aim was to evaluate dermal lymphatic vessels in patients with SSc according to different phases of skin involvement...
  20. ncbi request reprint Domain 1 of the urokinase-type plasminogen activator receptor is required for its morphologic and functional, beta2 integrin-mediated connection with actin cytoskeleton in human microvascular endothelial cells: failure of association in systemic sclerosis
    Francesca Margheri
    University of Florence, Florence, Italy
    Arthritis Rheum 54:3926-38. 2006
    ....
  21. doi request reprint Evidence for the prevention of enthesitis in HLA-B27/hβ(2)m transgenic rats treated with a monoclonal antibody against TNF-α
    Anna Franca Milia
    Department of Biomedicine, Division of Rheumatology, University of Florence, Florence, Italy
    J Cell Mol Med 15:270-9. 2011
    ..In B27TR, articular involvement follows IBD onset and develops at entheses. Early TNF-α blockade prevents the onset of IBD and consequently the development of enthesitis in peripheral joints in the B27TR model of human SpA...
  22. doi request reprint Endothelial/lymphocyte activation leads to prominent CD4+ T cell infiltration in the gastric mucosa of patients with systemic sclerosis
    Mirko Manetti
    University of Florence, Florence, Italy
    Arthritis Rheum 58:2866-73. 2008
    ..The aim of the present study was to investigate whether immune and/or microvascular abnormalities may account for tissue damage in gastric wall specimens obtained from patients with SSc...
  23. ncbi request reprint Telocytes in Crohn's disease
    Anna Franca Milia
    Department of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence, Florence, Italy
    J Cell Mol Med 17:1525-36. 2013
    ..Further functional studies are necessary to better clarify the role of TC loss in CD pathophysiology. ..
  24. doi request reprint RANK-RANKL-OPG in hemophilic arthropathy: from clinical and imaging diagnosis to histopathology
    Daniela Melchiorre
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Florence, Italy
    J Rheumatol 39:1678-86. 2012
    ..Our aim was to evaluate RANK-RANKL-OPG expression in the synovium of hemophilic patients with severe arthropathy...
  25. doi request reprint Autologous mesenchymal stem cells foster revascularization of ischemic limbs in systemic sclerosis: a case report
    Serena Guiducci
    Azienda Ospedaliero Universitaria Careggi and University of Florence, Florence, Italy
    Ann Intern Med 153:650-4. 2010
    ..In experimental models of acute myocardial infarction, mesenchymal stem cells led to the recovery of cardiac function through the formation of a new vascular network...
  26. ncbi request reprint Inactivation of urokinase-type plasminogen activator receptor (uPAR) gene induces dermal and pulmonary fibrosis and peripheral microvasculopathy in mice: a new model of experimental scleroderma?
    Mirko Manetti
    Department of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence, Florence, Italy
    Ann Rheum Dis . 2013
    ..In the present study, we investigated whether uPAR gene inactivation in mice could result in tissue fibrosis and peripheral microvasculopathy resembling human SSc...
  27. ncbi request reprint Variations of neuronal nitric oxide synthase in systemic sclerosis skin
    Lidia Ibba-Manneschi
    Dept of Anatomy, Histology and Forensic Medicine, University of Florence, Viale G B Morgagni 85, 50134 Florence, Italy
    Arthritis Rheum 54:202-13. 2006
    ..This study was performed to verify, by immunohistochemical and biochemical analyses, the presence and expression of nNOS and protein gene product 9.5 (PGP 9.5) in SSc skin, in different subsets and various phases of the disease...
  28. doi request reprint Telocytes express PDGFRα in the human gastrointestinal tract
    Maria Giuliana Vannucchi
    Department of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence, Florence, Italy
    J Cell Mol Med 17:1099-108. 2013
    ..In conclusion, in the human GI tract the TC are PDGFRα-positive and, therefore, might correspond to the FLC. We also hypothesize that in human gut, there are different TC subpopulations probably playing region-specific roles. ..
  29. doi request reprint TNFalpha blockade prevents the development of inflammatory bowel disease in HLA-B27 transgenic rats
    Anna Franca Milia
    Department of Biomedicine, Division of Rheumatology, University of Florence, Florence, Italy
    J Cell Mol Med 13:164-76. 2009
    ..Anti-TNFalpha treatment increased Fas-L expression, whereas Fas increased only with the early treatment. TNFalpha blockade is effective in preventing inflammation in early phase of IBD, maintaining the homeostatic balance of apoptosis...