M Manco

Summary

Country: Italy

Publications

  1. ncbi request reprint Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion
    Aldo V Greco
    Department of Medicine, Catholic University, Rome, Italy
    Diabetes 51:144-51. 2002
  2. ncbi request reprint Lowering of circulating free-fatty acids levels and reduced expression of leptin in white adipose tissue in postobesity status
    Aldo V Greco
    Istituto di Medicina Interna, Universita Cattolica S Cuore, Rome, Italy
    J Investig Med 50:207-13. 2002
  3. doi request reprint Retinol-binding protein 4: a promising circulating marker of liver damage in pediatric nonalcoholic fatty liver disease
    Valerio Nobili
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Clin Gastroenterol Hepatol 7:575-9. 2009
  4. pmc Back to past leeches: repeated phlebotomies and cardiovascular risk
    Melania Manco
    Bambino Gesu Children s Hospital and Research Institute, Research Unit for Multifactorial Disease, Rome, Italy
    BMC Med 10:53. 2012
  5. ncbi request reprint Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women
    Melania Manco
    Department of Internal Medicine, Catholic University, Rome, Italy
    J Clin Endocrinol Metab 92:483-90. 2007
  6. doi request reprint Gut microbiota, lipopolysaccharides, and innate immunity in the pathogenesis of obesity and cardiovascular risk
    Melania Manco
    Bambino Gesu Hospital, Instituto di Ricovero e Cura a Carattere Scientifico, Piazza San Onofrio 4, I 00165 Rome, Italy
    Endocr Rev 31:817-44. 2010
  7. pmc One-hour plasma glucose identifies insulin resistance and beta-cell dysfunction in individuals with normal glucose tolerance: cross-sectional data from the Relationship between Insulin Sensitivity and Cardiovascular Risk (RISC) study
    Melania Manco
    Bambino Gesu Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    Diabetes Care 33:2090-7. 2010
  8. ncbi request reprint Insulin dynamics of breast- or formula-fed overweight and obese children
    Melania Manco
    Scientific Directorate and Liver Unit, Paediatric Hospital Bambino Gesu and Research Institute Rome
    J Am Coll Nutr 30:29-38. 2011
  9. ncbi request reprint Biliopancreatic diversion as a novel approach to the HAIR-AN syndrome
    Melania Manco
    Department of Internal Medicine, Catholic University, School of Medicine, Rome, Italy
    Obes Surg 15:286-9. 2005
  10. doi request reprint The decrease of serum levels of human neutrophil alpha-defensins parallels with the surgery-induced amelioration of NASH in obesity
    Melania Manco
    Scientific Directorate, Bambino Gesù Hospital and Research Institute, Rome, Italy
    Obes Surg 20:1682-9. 2010

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion
    Aldo V Greco
    Department of Medicine, Catholic University, Rome, Italy
    Diabetes 51:144-51. 2002
    ....
  2. ncbi request reprint Lowering of circulating free-fatty acids levels and reduced expression of leptin in white adipose tissue in postobesity status
    Aldo V Greco
    Istituto di Medicina Interna, Universita Cattolica S Cuore, Rome, Italy
    J Investig Med 50:207-13. 2002
    ..Our aim was to investigate the regulation of the gene expression of leptin in subcutaneous adipose tissue biopsies in morbid obesity before and after biliopancreatic diversion (BPD)...
  3. doi request reprint Retinol-binding protein 4: a promising circulating marker of liver damage in pediatric nonalcoholic fatty liver disease
    Valerio Nobili
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Clin Gastroenterol Hepatol 7:575-9. 2009
    ..We tested the serum levels of RBP4 to assess their associations with the metabolic profile and histologic features in a large well-characterized group of children with NAFLD...
  4. pmc Back to past leeches: repeated phlebotomies and cardiovascular risk
    Melania Manco
    Bambino Gesu Children s Hospital and Research Institute, Research Unit for Multifactorial Disease, Rome, Italy
    BMC Med 10:53. 2012
    ..Please see related article: http://www.biomedcentral.com/1741-7015/10/54...
  5. ncbi request reprint Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women
    Melania Manco
    Department of Internal Medicine, Catholic University, Rome, Italy
    J Clin Endocrinol Metab 92:483-90. 2007
    ..Obesity may be regarded as a low-grade inflammatory state...
  6. doi request reprint Gut microbiota, lipopolysaccharides, and innate immunity in the pathogenesis of obesity and cardiovascular risk
    Melania Manco
    Bambino Gesu Hospital, Instituto di Ricovero e Cura a Carattere Scientifico, Piazza San Onofrio 4, I 00165 Rome, Italy
    Endocr Rev 31:817-44. 2010
    ..This review gives a comprehensive breakdown of the interaction among gut microbiota, LPSs, and the innate immune system in the development of obesity and promotion of an individual's cardiovascular risk...
  7. pmc One-hour plasma glucose identifies insulin resistance and beta-cell dysfunction in individuals with normal glucose tolerance: cross-sectional data from the Relationship between Insulin Sensitivity and Cardiovascular Risk (RISC) study
    Melania Manco
    Bambino Gesu Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    Diabetes Care 33:2090-7. 2010
    ..The aim of this study was to characterize their metabolic phenotype...
  8. ncbi request reprint Insulin dynamics of breast- or formula-fed overweight and obese children
    Melania Manco
    Scientific Directorate and Liver Unit, Paediatric Hospital Bambino Gesu and Research Institute Rome
    J Am Coll Nutr 30:29-38. 2011
    ..The aim of the present study was to evaluate the association between the type of early feeding and indices of insulin metabolism in 8-year-old overweight and obese children...
  9. ncbi request reprint Biliopancreatic diversion as a novel approach to the HAIR-AN syndrome
    Melania Manco
    Department of Internal Medicine, Catholic University, School of Medicine, Rome, Italy
    Obes Surg 15:286-9. 2005
    ..The HAIR-AN syndrome is a rare multisystem disorder in women, that consists of hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN). The IR is likely due to a primary defect of the insulin receptor...
  10. doi request reprint The decrease of serum levels of human neutrophil alpha-defensins parallels with the surgery-induced amelioration of NASH in obesity
    Melania Manco
    Scientific Directorate, Bambino Gesù Hospital and Research Institute, Rome, Italy
    Obes Surg 20:1682-9. 2010
    ..Among them, both soluble CD14 receptor (sCD14) and human neutrophil alpha-defensins (HNDs) may represent serum markers of necro-inflammation in obese patients with non-alcoholic fatty liver disease...
  11. doi request reprint Albuminuria and insulin resistance in children with biopsy proven non-alcoholic fatty liver disease
    Melania Manco
    Scientific Directorate, Bambino Gesu Hospital, Research Institute IRCCS, 00165, Rome, Italy
    Pediatr Nephrol 24:1211-7. 2009
    ..Longitudinal studies are needed to rule out any causative relationship between insulin resistance and urinary albumin excretion...
  12. ncbi request reprint Metabolic syndrome and liver histology in paediatric non-alcoholic steatohepatitis
    M Manco
    Liver Unit, Pathology Department, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Int J Obes (Lond) 32:381-7. 2008
    ....
  13. ncbi request reprint Massive weight loss decreases corticosteroid-binding globulin levels and increases free cortisol in healthy obese patients: an adaptive phenomenon?
    Melania Manco
    Liver Unit, Bambino Gesù Hospital and Research Institute, Rome, Italy
    Diabetes Care 30:1494-500. 2007
    ..In this study, we aim to investigate the effects of massive weight loss on cortisol suppressibility, cortisol-binding globulin (CBG), and free cortisol index (FCI) in formerly obese women...
  14. ncbi request reprint Nonalcoholic fatty liver disease in children
    Melania Manco
    Catholic University, Rome, Italy
    J Am Coll Nutr 27:667-76. 2008
    ..In this article, we review the current concepts about paediatric NAFLD, its pathogenesis, diagnosis and treatment, with particular regard to lifestyle and foods habits...
  15. doi request reprint Insulin resistance and exercise capacity in male children and adolescents with non-alcholic fatty liver disease
    Melania Manco
    Scientific Directorate, Bambino Gesu Children s Hospital and Research Institute, S Onofrio 4 Square, 00165, Rome, Italy
    Acta Diabetol 46:97-104. 2009
    ....
  16. doi request reprint Intima-media thickness and liver histology in obese children and adolescents with non-alcoholic fatty liver disease
    Melania Manco
    Scientific Directorate, Pediatric Hospital Bambino Gesu, IRCCS, Piazza San Onofrio 4, 00165 Rome, Italy
    Atherosclerosis 209:463-8. 2010
    ..To evaluate the relationship between biopsy-proven non-alcoholic fatty liver disease (NAFLD) and carotid artery intima-media thickness (CIMT) in children and adolescents...
  17. ncbi request reprint Menopause, insulin resistance, and risk factors for cardiovascular disease
    Melania Manco
    Institute of Internal Medicine, Catholic University, Rome, Italy
    Menopause 13:809-17. 2006
    ....
  18. ncbi request reprint Intramyocitic lipid accumulation and SREBP-1c expression are related to insulin resistance and cardiovascular risk in morbid obesity
    G Mingrone
    Istituto di Clinica Medica, Universita Cattolica del Sacro Cuore, Rome, Italy
    Atherosclerosis 170:155-61. 2003
    ....
  19. doi request reprint Waist circumference correlates with liver fibrosis in children with non-alcoholic steatohepatitis
    M Manco
    Department of Hepatogastroenterology and Nutrition, Paediatric Hospital Bambino Gesu, IRCCS, Rome, Italy
    Gut 57:1283-7. 2008
    ..Non-alcoholic fatty liver disease (NAFLD) is a feature of the metabolic syndrome. A contribution of metabolic syndrome, and especially of waist circumference, to liver fibrosis in children with NAFLD is strongly suspected...
  20. pmc Mechanisms of hyperinsulinaemia in Child's disease grade B liver cirrhosis investigated in free living conditions
    A V Greco
    Istituto di Medicina Interna, Universita Cattolica S Cuore, Rome, Italy
    Gut 51:870-5. 2002
    ..To investigate these issues, insulin secretion-during 24 hours of standardised living conditions-insulin sensitivity, and hepatic insulin extraction were assessed in cirrhotic patients compared with matched healthy subjects...
  21. doi request reprint Twenty-four hour insulin secretion and beta cell NEFA oxidation in type 2 diabetic, morbidly obese patients before and after bariatric surgery
    S Salinari
    Department of Systems Analysis and Informatics, University of Rome La Sapienza, Via Ariosto 25, 00185, Rome, Italy
    Diabetologia 51:1276-84. 2008
    ....
  22. ncbi request reprint Molecular mechanisms of diabetes reversibility after bariatric surgery
    G Rosa
    Department of Internal Medicine, Catholic University S Cuore, Rome, Italy
    Int J Obes (Lond) 31:1429-36. 2007
    ..Peripheral insulin sensitivity and insulin secretion was also measured...
  23. ncbi request reprint Could the low level of expression of the gene encoding skeletal muscle mitofusin-2 account for the metabolic inflexibility of obesity?
    G Mingrone
    Department of Internal Medicine, Catholic University, Largo A Gemelli 8, 00168 Rome, Italy
    Diabetologia 48:2108-14. 2005
    ..The aim of this study was to verify whether MFN2 might be implicated in the metabolic inflexibility of obesity...
  24. ncbi request reprint Skeletal muscle triglycerides lowering is associated with net improvement of insulin sensitivity, TNF-alpha reduction and GLUT4 expression enhancement
    G Mingrone
    Istituto di Medicina Interna, Universita Cattolica S Cuore, Rome, Italy
    Int J Obes Relat Metab Disord 26:1165-72. 2002
    ..The aim of the present study was to investigate the relationship between intramyocytic triglycerides levels, muscle TNF-alpha and GLUT4 expression and insulin resistance...
  25. ncbi request reprint Reduced PDK4 expression associates with increased insulin sensitivity in postobese patients
    Giuseppina Rosa
    Department of Internal Medicine, Surgery, and Consiglio Nazionale della Ricerca CNR Center Catholic University of the Sacred Heart, Rome, Italy
    Obes Res 11:176-82. 2003
    ....
  26. ncbi request reprint Lowered tumor necrosis factor receptors, but not increased insulin sensitivity, with infliximab
    Paola Di Rocco
    Institute of Internal Medicine, Catholic University of Sacred Heart, Rome, Italy
    Obes Res 12:734-9. 2004
    ..To verify whether Infliximab could modify insulin sensitivity and TNF-alpha and GLUT4 mRNA expression in muscle and adipose tissue of morbidly obese subjects. Soluble TNF receptors I and II (TNFR-I and TNFR-II) were also assayed...
  27. ncbi request reprint Predictors of weight loss and reversal of comorbidities in malabsorptive bariatric surgery
    Maria E Valera-Mora
    Department of Internal Medicine, Catholic University of Rome, Rome, Italy
    Am J Clin Nutr 81:1292-7. 2005
    ..Cardiovascular and metabolic comorbidities are dramatically increased in severe obesity, a condition highly resistant to nonsurgical therapy...
  28. ncbi request reprint Effect of vitamin E on aminotransferase levels and insulin resistance in children with non-alcoholic fatty liver disease
    V Nobili
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Aliment Pharmacol Ther 24:1553-61. 2006
    ..Few data are available on the effect of antioxidants in paediatric non-alcoholic fatty liver disease (NAFLD)...
  29. ncbi request reprint Ultradian ghrelin pulsatility is disrupted in morbidly obese subjects after weight loss induced by malabsorptive bariatric surgery
    Geltrude Mingrone
    Department of Internal Medicine, CNR Centro di Fisiopatologia dello Shock, Catholic University, School of Medicine, Rome, Italy
    Am J Clin Nutr 83:1017-24. 2006
    ..Suppression of ghrelin production after Roux-en-Y gastric bypass that suggested its contribution to appetite reduction has been reported...
  30. ncbi request reprint beta-cell function in morbidly obese subjects during free living: long-term effects of weight loss
    Stefania Camastra
    Department of Internal Medicine, Metabolism Unit, National Research Council Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Diabetes 54:2382-9. 2005
    ..With continued weight loss over a 2-year period, moderately obese subjects become supersensitive to insulin and, correspondingly, insulin hyposecretors...
  31. ncbi request reprint Decreased muscle acetyl-coenzyme A carboxylase 2 mRNA and insulin resistance in formerly obese subjects
    Giuseppina Rosa
    Department of Internal Medicine, Consiglio Nazionale delle Richerche CNR Center, Catholic University of the Sacred Heart, Largo A Gemelli 8, 00168 Rome, Italy
    Obes Res 11:1306-12. 2003
    ..We assessed ACC2 mRNA expression variations in skeletal muscle of subjects who have undergone biliopancreatic diversion (BPD) operation. BPD, in fact inducing a massive lipid malabsorption, leads to a reversion of insulin resistance...
  32. ncbi request reprint Leptin pulsatility in formerly obese women
    Geltrude Mingrone
    Department of Internal Medicine, CNR Centro di Fisiopatologia dello Shock, Catholic University, School of Medicine, Rome, Italy
    FASEB J 19:1380-2. 2005
    ..Finally, since leptin inhibits GH secretion, a reduction of circulating leptin levels might have produced an increase in GH secretion, as observed in our series...
  33. doi request reprint 1-Hour plasma glucose in obese youth
    M Manco
    Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Pediatrico Bambino Gesu, Rome, Italy
    Acta Diabetol 49:435-43. 2012
    ..1HPG ≥ 132.5 mg/dl seems to be associated with increased metabolic risk in obese youth, identifying patients with lower insulin sensitivity, early secretion, and higher total insulin secretion than in obese mates with lower 1HPG...
  34. ncbi request reprint Growth hormone and ghrelin secretion in severely obese women before and after bariatric surgery
    Maria E Valera Mora
    Department of Internal Medicine, Metabolic Unit, Universita Cattolica S Cuore, Rome, Italy
    Obesity (Silver Spring) 15:2012-8. 2007
    ..The objective was to evaluate ghrelin and growth hormone (GH) interactions and responses to a growth hormone-releasing hormone (GHRH)/arginine test in severe obesity before and after surgically-induced weight loss...
  35. ncbi request reprint Decreased uncoupling protein expression and intramyocytic triglyceride depletion in formerly obese subjects
    Geltrude Mingrone
    Istituto di Clinica Medica and Clinica Chirurgica and Centro CNR Fisiopatologia Shock, Universita Cattolica S Cuore, Rome, Italy
    Obes Res 11:632-40. 2003
    ..To examine the muscular uncoupling protein expression 2 (UCP2) and UCP3 gene expression in morbid obese subjects before and after bariatric surgery [bilio-pancreatic diversion (BPD)]...
  36. doi request reprint Metformin use in children with nonalcoholic fatty liver disease: an open-label, 24-month, observational pilot study
    Valerio Nobili
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Clin Ther 30:1168-76. 2008
    ..There is no consensus on the treatment of pediatric nonalcoholic fatty liver disease (NAFLD). However, in a small pilot study conducted in 10 children, metformin has been proposed to be effective...
  37. doi request reprint Severity of liver injury and atherogenic lipid profile in children with nonalcoholic fatty liver disease
    Valerio Nobili
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Pediatr Res 67:665-70. 2010
    ....
  38. doi request reprint Endotoxin and plasminogen activator inhibitor-1 serum levels associated with nonalcoholic steatohepatitis in children
    Anna Alisi
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    J Pediatr Gastroenterol Nutr 50:645-9. 2010
    ..We investigated the association between serum levels of endotoxin, proinflammatory molecules, and histology in children with NAFLD...
  39. pmc Influence of maternal obesity on insulin sensitivity and secretion in offspring
    Geltrude Mingrone
    Medicine and Diabetes Center, Universita Cattolica S Cuore, Rome, Italy
    Diabetes Care 31:1872-6. 2008
    ..The purpose of this study was to clarify the effects of maternal obesity on insulin sensitivity and secretion in offspring...
  40. doi request reprint Prolactin and insulin ultradian secretion and adipose tissue lipoprotein lipase expression in severely obese women after bariatric surgery
    Geltrude Mingrone
    Department of Internal Medicine, Universita Cattolica S Cuore, Rome, Italy
    Obesity (Silver Spring) 16:1831-7. 2008
    ..Hyperprolactinemia is associated with obesity. Furthermore, in human adipose tissue cultured in vitro, prolactin (PRL) inhibited lipoprotein lipase (LPL) activity via functional PRL receptors...
  41. doi request reprint Sexual dimorphism of body composition and insulin sensitivity across pubertal development in obese Caucasian subjects
    Claudia Brufani
    Endocrinology and Diabetes Unit, Department of Paediatric Medicine, Bambino Gesu Children s Hospital IRCCS, Piazza S Onofrio 4, 00165 Rome, Italy
    Eur J Endocrinol 160:769-75. 2009
    ..Factors that independently from T or age influence IS are central fat depot in girls, lean amount in boys, and total fat mass in both sexes...
  42. doi request reprint Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: a randomized, controlled trial
    Valerio Nobili
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Hepatology 48:119-28. 2008
    ..The improvement in all these parameters was not significantly different between the two groups...
  43. ncbi request reprint Changes in fat mass influence SREBP-1c and UCP-2 gene expression in formerly obese subjects
    Donatella Gniuli
    Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Obes Res 13:567-73. 2005
    ..Body composition was assessed by isotopic dilution method and insulin sensitivity by euglycemic-hyperinsulinemic clamp...
  44. ncbi request reprint Mechanisms of recovery from type 2 diabetes after malabsorptive bariatric surgery
    Caterina Guidone
    Dipartimento di Medicina Interna, Catholic University, Largo A Gemelli, 8, 00168 Rome, Italy
    Diabetes 55:2025-31. 2006
    ..This operation may affect the enteroinsular axis function by diverting nutrients away from the proximal gastrointestinal tract and by delivering incompletely digested nutrients to the ileum...
  45. ncbi request reprint Effects of weight loss and calorie restriction on carbohydrate metabolism
    Melania Manco
    Department of Internal Medicine and Clinical Science, Catholic University, Rome, Italy
    Curr Opin Clin Nutr Metab Care 8:431-9. 2005
    ..The topics covered include insulin secretion and resistance, glucose homeostasis and allostasis, changes in the secretive patterns of adipose tissue and the entero-insular axis...
  46. ncbi request reprint Restoration of adiponectin pulsatility in severely obese subjects after weight loss
    Menotti Calvani
    Department of Internal Medicine, Consiglio Nazionale delle Ricerche Centro di Fisiopatologia dello Shock, Catholic University, School of Medicine, Rome, Italy
    Diabetes 53:939-47. 2004
    ....
  47. ncbi request reprint Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease
    Melania Manco
    Liver Unit, Bambino Gesu Children s Hospital and Research Institute, Rome, Italy
    Am J Clin Pathol 127:954-60. 2007
    ..TNF-alpha alone or combined with leptin in a simple risk score can accurately predict a NAS of 5 or more. TNF-alpha seems to be a specific laboratory marker of NASH...
  48. ncbi request reprint Leptin, free leptin index, insulin resistance and liver fibrosis in children with non-alcoholic fatty liver disease
    Valerio Nobili
    Liver Unit, Research Institute, Bambino Gesu Children s Hospital, S Onofrio 4 Square, 00165 Rome, Italy
    Eur J Endocrinol 155:735-43. 2006
    ..A role for leptin has been claimed. This study aims to evaluate the relationship between leptin, insulin resistance (IR) and NAFLD in children...
  49. ncbi request reprint The ingestion of saturated fatty acid triacylglycerols acutely affects insulin secretion and insulin sensitivity in human subjects
    Melania Manco
    Institute of Internal Medicine, Catholic University S Cuore, School of Medicine, Rome, Italy
    Br J Nutr 92:895-903. 2004
    ..The data are consistent with the hypothesis that acute excess lipid availability may lead to a compensatory elevation in glucose-induced insulin secretion as a result of the decline in insulin sensitivity and a reduced insulin clearance...
  50. ncbi request reprint Hypocalcemia complicating near-total thyroidectomy in patients with coexisting lipid malabsorption due to biliopancreatic diversion
    Melania Manco
    Department of Internal Medicine, CNR Centro di Fisiopatologia dello Shock, Catholic University, School of Medicine, Rome, Italy
    Obes Surg 14:1429-34. 2004
    ..Patients who have undergone biliopancreatic diversion (BPD) show a high incidence of mild hypocalcemia, which may become symptomatic and life-treating after an extensive thyroid operation...
  51. ncbi request reprint Beta-cell function in severely obese type 2 diabetic patients: long-term effects of bariatric surgery
    Stefania Camastra
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetes Care 30:1002-4. 2007
  52. ncbi request reprint Therapeutic strategies for pediatric non-alcoholic fatty liver disease: a challenge for health care providers
    Valerio Nobili
    Liver Unit, Research Institute, Bambino Gesu Children s Hospital, S Onofrio 4 Square, Rome, Italy
    World J Gastroenterol 13:2639-41. 2007
    ..Therapeutic approaches have aimed at treating associated conditions (obesity, insulin resistance, hyperlipemia, etc) or reducing liver oxidative damage (vitamin E)...
  53. ncbi request reprint Bloodletting ameliorates insulin sensitivity and secretion in parallel to reducing liver iron in carriers of HFE gene mutations
    Francesco Equitani
    Transfusion Medicine, SanFilippo Neri Hospital, Rome, Italy
    Diabetes Care 31:3-8. 2008
    ..To clarify the pathogenesis of diabetes associated with mutations of the hemochromatosis (HFE) gene, 17 carriers, 9 normal glucose tolerant (NGT) and 8 diabetic, were evaluated in an interventional trial...
  54. ncbi request reprint Intrauterine growth retardation, insulin resistance, and nonalcoholic fatty liver disease in children
    Valerio Nobili
    Liver Unit, Research Institute, Bambino Gesu Children s Hospital, Piazza S Onofrio 4, 00165 Rome, Italy
    Diabetes Care 30:2638-40. 2007
  55. doi request reprint Acoustic radiation force impulse (ARFI) imaging with Virtual Touch Tissue Quantification in liver disease associated with cystic fibrosis in children
    L Monti
    Radiology Department, Bambino Gesu Hospital, IRCCS, Rome, Italy
    Radiol Med 117:1408-18. 2012
    ..The aim of the study was to evaluate the performance of acoustic radiation force impulse (ARFI) with virtual tissue quantification in comparison with clinical signs, biochemistry and standard hepatic ultrasound (US) patterns...
  56. pmc First-phase insulin secretion restoration and differential response to glucose load depending on the route of administration in type 2 diabetic subjects after bariatric surgery
    Serenella Salinari
    Department of Systems Analysis and Informatics, University of Rome La Sapienza, Rome, Italy
    Diabetes Care 32:375-80. 2009
    ..The purpose of this study was to elucidate the mechanisms of diabetes reversibility after malabsorptive bariatric surgery...
  57. ncbi request reprint Low 25-hydroxyvitamin D does not affect insulin sensitivity in obesity after bariatric surgery
    Melania Manco
    Department of Internal Medicine, Catholic University, School of Medicine, 484 Pineta Sacchetti, 00168 Rome, Italy
    Obes Res 13:1692-700. 2005
    ..We aimed to test the hypothesis that concentration of 25(OH)D influences insulin sensitivity in obesity before and after weight loss...
  58. ncbi request reprint Effects of dietary fatty acids on insulin sensitivity and secretion
    Melania Manco
    Institute of Internal Medicine, Catholic University, 00168 Rome, Italy
    Diabetes Obes Metab 6:402-13. 2004
    ..In humans, acute and prolonged effects of FAs on glucose-stimulated insulin secretion have been widely investigated as well as the effect of high-fat diets on insulin sensitivity and secretion and on the development of type 2 diabetes...
  59. ncbi request reprint Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetic subjects
    Serenella Salinari
    Dipartimento di Informatica e Sistemistica, Universita di Roma La Sapienza, Rome, Italy
    Am J Physiol Endocrinol Metab 291:E1051-8. 2006
    ....
  60. ncbi request reprint Reduced expression of uncoupling proteins-2 and -3 in adipose tissue in post-obese patients submitted to biliopancreatic diversion
    Roberto Vettor
    Endocrine Metabolic Laboratory, Internal Medicine, Department of Medical and Surgical Sciences, University of Padua, Via Ospedale 105, 35128 Padua, Italy
    Eur J Endocrinol 148:543-50. 2003
    ..We investigated whether the expression of UCP-2 and -3 in adipose tissue was affected by weight loss due to a biliopancreatic diversion (BPD) and related to the daily energy expenditure (24-h EE)...
  61. ncbi request reprint Different fat distribution as marker of disease in nonalcholic fatty liver disease
    Melania Manco
    Hepatology 46:1310-1; author reply 1312. 2007
  62. ncbi request reprint Differential effect of weight loss on insulin resistance in surgically treated obese patients
    Elza Muscelli
    Department of Medicine, State University of Campinas, Sao Paulo, Brazil
    Am J Med 118:51-7. 2005
    ..To compare the effects of equivalent weight loss induced by two bariatric surgical techniques on insulin action in severely obese patients...
  63. ncbi request reprint Does the hormone of eternal youth protect against nonalcoholic steatohepatitis?
    Melania Manco
    Hepatology 48:1351. 2008
  64. ncbi request reprint NEFA-glucose comodulation model of beta-cell insulin secretion in 24-h multiple-meal test
    Serenella Salinari
    Department of Systems Analysis and Informatics, University of Rome La Sapienza, Italy
    Am J Physiol Endocrinol Metab 292:E1890-8. 2007
    ....
  65. ncbi request reprint Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6
    Daniel Bach
    Universitat de Barcelona, Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Avda Diagonal 645, Barcelona, Spain
    Diabetes 54:2685-93. 2005
    ....
  66. doi request reprint Intensive treatment and dietary fats in adolescents with nonalcoholic fatty liver disease
    Melania Manco
    J Pediatr Gastroenterol Nutr 46:224. 2008
  67. ncbi request reprint Lifestyle advice in non-alcoholic fatty liver disease
    Melania Manco
    J Gastroenterol Hepatol 22:604-5. 2007
  68. ncbi request reprint How much we worry for liver fat in children?
    Melania Manco
    Acta Paediatr 96:1373-4; author reply 1374-5. 2007
  69. ncbi request reprint How to consider low serum vitamin D as a risk factor for insulin resistance?
    Melania Manco
    Am J Clin Nutr 80:1450-1; author reply 1452-3. 2004
  70. doi request reprint Reduced cardio-respiratory fitness in obesity with and without nonalcoholic fatty liver disease
    Melania Manco
    Hepatology 48:690; author reply 690-1. 2008
  71. ncbi request reprint Measurement of advanced glycation end products may change NASH management
    Valerio Nobili
    J Gastroenterol Hepatol 22:1354-5. 2007
  72. ncbi request reprint Case management in children affected by non-alcoholic fatty liver disease
    Valerio Nobili
    J Paediatr Child Health 43:414. 2007